MCID: MLG059
MIFTS: 38

Malignant Struma Ovarii

Categories: Cancer diseases

Aliases & Classifications for Malignant Struma Ovarii

MalaCards integrated aliases for Malignant Struma Ovarii:

Name: Malignant Struma Ovarii 12 14
Struma Ovarii, Malignant 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5208
NCIt 46 C4291
SNOMED-CT 64 18854008
UMLS 69 C0334525

Summaries for Malignant Struma Ovarii

MalaCards based summary : Malignant Struma Ovarii, also known as struma ovarii, malignant, is related to struma ovarii and ovarian germ cell teratoma. An important gene associated with Malignant Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways and Pathways in cancer. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, liver and ovary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Malignant Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Malignant Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 struma ovarii 31.7 NKX2-1 RET TG
2 ovarian germ cell teratoma 29.9 NKX2-1 NRAS RET TG
3 papillary carcinoma 28.4 KRT19 LGALS3 NCOA4 NKX2-1 RET TG
4 thyroid cancer, nonmedullary, 2 28.3 HRAS KRT19 LGALS3 NKX2-1 NRAS RET
5 thyroid cancer, nonmedullary, 1 27.5 HRAS KRT19 LGALS3 NCOA4 NKX2-1 PTCH1
6 thyroid cancer 27.3 HRAS KRT19 LGALS3 NCOA4 NKX2-1 NRAS
7 thyroiditis 10.6
8 athyreosis 10.4 NKX2-1 TG
9 schimmelpenning-feuerstein-mims syndrome 10.4 HRAS NRAS
10 ovarian melanoma 10.4 HRAS NRAS
11 melanomatosis 10.3 HRAS NRAS
12 marcus gunn phenomenon 10.3 HRAS NRAS
13 malignant conjunctival melanoma 10.3 HRAS NRAS
14 nevus, epidermal 10.3 HRAS NRAS
15 myelodysplastic myeloproliferative cancer 10.3 HRAS NRAS
16 meningeal melanomatosis 10.3 HRAS NRAS
17 chromosome 14q11-q22 deletion syndrome 10.3 HRAS NKX2-1
18 melanocytic nevus syndrome, congenital 10.3 HRAS NRAS
19 vulvar melanoma 10.3 HRAS NRAS
20 acneiform dermatitis 10.3 HRAS NRAS
21 sporadic pheochromocytoma 10.3 HRAS RET
22 lung adenoid cystic carcinoma 10.3 HRAS NKX2-1
23 graves' disease 10.3
24 adenosquamous cell lung carcinoma 10.2 HRAS RET
25 papillary thyroid microcarcinoma 10.2 NKX2-1 TG
26 multiple endocrine neoplasia, type iib 10.2 PTCH1 RET
27 malignant skin fibrous histiocytoma 10.2 HRAS NRAS
28 core binding factor acute myeloid leukemia 10.2 HRAS NRAS
29 ovarian cystic teratoma 10.2 NKX2-1 TG
30 mucinous bronchioloalveolar adenocarcinoma 10.2 LGALS3 NKX2-1
31 biliary papillomatosis 10.2 HRAS KRT19
32 graves disease 1 10.2
33 teratoma 10.2
34 peritonitis 10.2
35 malignant dermis tumor 10.2 HRAS NRAS
36 thyroid cancer, anaplastic 10.2 NKX2-1 RET TG
37 colloid carcinoma of the pancreas 10.2 HRAS KRT19
38 thyroid carcinoma, familial medullary 10.1 NKX2-1 RET TG
39 central nervous system melanocytic neoplasm 10.1 HRAS NRAS
40 cystadenofibroma 10.1 AFP TG
41 rete testis adenocarcinoma 10.1 AFP NKX2-1
42 multinodular goiter 10.1 HRAS NKX2-1 TG
43 nodular goiter 10.1 LGALS3 RET TG
44 rete testis neoplasm 10.1 AFP NKX2-1
45 intrahepatic bile duct adenoma 10.0 AFP KRT19
46 integumentary system cancer 10.0 HRAS NRAS PTCH1
47 dyskinetic cerebral palsy 10.0 AFP NKX2-1
48 lymphedema, hereditary, ii 10.0
49 cervicitis 10.0
50 adenocarcinoma 10.0

Graphical network of the top 20 diseases related to Malignant Struma Ovarii:



Diseases related to Malignant Struma Ovarii

Symptoms & Phenotypes for Malignant Struma Ovarii

GenomeRNAi Phenotypes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.4 NRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.4 RET
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.4 NRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.4 RET
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.4 HRAS NRAS RET
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.4 RET
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 HRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 NRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.4 HRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.4 HRAS

MGI Mouse Phenotypes related to Malignant Struma Ovarii:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.11 NRAS TG PTCH1 RET AFP LGALS3
2 behavior/neurological MP:0005386 10.08 RET NRAS PTCH1 AFP LGALS3 HRAS
3 endocrine/exocrine gland MP:0005379 10.08 TG PTCH1 RET NRAS AFP HRAS
4 cardiovascular system MP:0005385 10.07 NRAS PTCH1 RET LGALS3 HRAS NKX2-1
5 cellular MP:0005384 10.05 RET NRAS PTCH1 NKX2-1 KRT19 LGALS3
6 digestive/alimentary MP:0005381 10.04 PTCH1 RET NRAS LGALS3 HRAS NKX2-1
7 mortality/aging MP:0010768 10.03 RET NRAS PTCH1 KRT19 AFP LGALS3
8 neoplasm MP:0002006 10.01 PTCH1 RET NRAS AFP LGALS3 HRAS
9 nervous system MP:0003631 9.91 RET TG PTCH1 KRT19 LGALS3 HRAS
10 no phenotypic analysis MP:0003012 9.8 NRAS PTCH1 RET HRAS NKX2-1 KRT19
11 normal MP:0002873 9.73 RET NRAS PTCH1 HRAS NKX2-1 KRT19
12 reproductive system MP:0005389 9.63 RET PTCH1 AFP LGALS3 NKX2-1 KRT19
13 respiratory system MP:0005388 9.35 RET PTCH1 NKX2-1 LGALS3 HRAS
14 skeleton MP:0005390 9.1 NRAS PTCH1 LGALS3 HRAS NKX2-1 KRT19

Drugs & Therapeutics for Malignant Struma Ovarii

Drugs for Malignant Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists
2 Hormones
3 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment Completed NCT01441154

Search NIH Clinical Center for Malignant Struma Ovarii

Genetic Tests for Malignant Struma Ovarii

Anatomical Context for Malignant Struma Ovarii

MalaCards organs/tissues related to Malignant Struma Ovarii:

38
Thyroid, Liver, Ovary, Bone, Eye

Publications for Malignant Struma Ovarii

Articles related to Malignant Struma Ovarii:

(show top 50) (show all 85)
# Title Authors Year
1
Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii: A Case Report. ( 29286966 )
2017
2
Malignant struma ovarii harboring a unique NRAS mutation: case report and review of the literature. ( 29278520 )
2017
3
Malignant Struma ovarii in a 30-year old nulliparous patient. ( 28572843 )
2017
4
Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report. ( 28982046 )
2017
5
Metastatic malignant struma ovarii: Two scenarios of the same pathology. ( 28440778 )
2017
6
Sincronous malignant struma ovarii and papillary thyroid carcinoma. ( 27297016 )
2016
7
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. ( 27843812 )
2016
8
A Hormonally Active Malignant Struma Ovarii. ( 27882257 )
2016
9
Management dilemma of thyroid nodules in patients with malignant struma ovarii. ( 27563566 )
2016
10
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. ( 26791568 )
2016
11
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. ( 27566096 )
2016
12
Treatment and follow-up of malignant struma ovarii: Regarding two cases. ( 27355004 )
2016
13
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. ( 27224256 )
2016
14
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. ( 26262453 )
2015
15
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. ( 26630220 )
2015
16
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. ( 25474425 )
2014
17
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. ( 25375817 )
2014
18
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. ( 24152665 )
2014
19
Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: A case report. ( 25364407 )
2014
20
The lack of consensus in management of malignant struma ovarii. ( 25539066 )
2014
21
Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. ( 24217901 )
2013
22
Synchronous papillary carcinoma thyroid with malignant struma ovarii: A management dilemma. ( 24379539 )
2013
23
Two cases of malignant struma ovarii with metastasis to pelvic bone. ( 23391779 )
2013
24
Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. ( 22288964 )
2012
25
Malignant struma ovarii: the west of Scotland experience and review of literature with focus on postoperative management. ( 22883659 )
2012
26
Laparoscopic excision of malignant struma ovarii and 1 year follow-up without further treatment. ( 21269611 )
2011
27
Malignant struma ovarii complicated by Trousseau's syndrome and repeated episodes of cerebral ischemic strokes: A case report. ( 24371609 )
2011
28
Metastatic malignant struma ovarii. ( 21598816 )
2011
29
Unilateral malignant struma ovarii in a case of bilateral ovarian teratoma with raised CA-125 level: a rare case with treatment dilemmas. ( 21934226 )
2011
30
Unusual characteristics and fatal outcome of a malignant struma ovarii. Case report and literature review. ( 21531638 )
2011
31
Malignant struma ovarii: a case report. ( 20119594 )
2010
32
Malignant struma ovarii. ( 20375218 )
2010
33
Metastasis of malignant struma ovarii to the lumbar spine. ( 20036545 )
2010
34
Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread. ( 20407319 )
2010
35
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. ( 19772400 )
2009
36
Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. ( 19696610 )
2009
37
Malignant struma ovarii: good response after thyroidectomy and I ablation therapy. ( 21892277 )
2008
38
An unusual variant of malignant struma ovarii. ( 18678124 )
2008
39
Malignant struma ovarii demonstrated on post-therapy radioiodine scan after total thyroidectomy for papillary thyroid cancer. ( 18496456 )
2008
40
Malignant struma ovarii. ( 18560398 )
2008
41
Malignant struma ovarii with a focus of papillary thyroid cancer: a case report. ( 17882443 )
2008
42
Malignant struma ovarii--a case report and review of the literature. ( 17890867 )
2008
43
BRAF T1799A mutation occurring in a case of malignant struma ovarii. ( 17478764 )
2007
44
Malignant struma ovarii: a case report and review of the literature. ( 17646728 )
2007
45
Malignant struma ovarii: a case report. ( 16047952 )
2005
46
Malignant struma ovarii mimic clear cell carcinoma. ( 14986024 )
2005
47
Malignant struma ovarii with peritoneal implants and pelvic structures and liver metastases demonstrated by I-131 SPECT and low-dose CT. ( 16319636 )
2005
48
Is the I-131 whole-body scanning proper for follow-up management of the patients with malignant struma ovarii without performing the thyroidectomy? ( 15963556 )
2005
49
Pseudo-Meigs' syndrome associated with malignant struma ovarii: a case report. ( 15262148 )
2004
50
Case report: Malignant struma ovarii. ( 15038677 )
2004

Variations for Malignant Struma Ovarii

Expression for Malignant Struma Ovarii

Search GEO for disease gene expression data for Malignant Struma Ovarii.

Pathways for Malignant Struma Ovarii

Pathways related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.11 HRAS NRAS PTCH1
2 12.08 HRAS NCOA4 NRAS PTCH1 RET
3 12.03 HRAS NRAS PTCH1
4 11.9 HRAS NRAS PTCH1
5
Show member pathways
11.83 HRAS NRAS RET
6
Show member pathways
11.35 HRAS NRAS RET
7 11.21 HRAS NRAS
8 11.16 HRAS RET
9 11.15 HRAS RET
10 11.14 HRAS NRAS RET
11 11.09 HRAS NRAS
12 11.01 HRAS NRAS
13 11 HRAS NRAS
14
Show member pathways
10.97 HRAS NRAS
15
Show member pathways
10.91 HRAS NRAS
16 10.82 HRAS NRAS
17 10.75 HRAS NRAS
18 10.67 HRAS NRAS
19 10.48 HRAS NRAS RET
20 10.44 HRAS NRAS

GO Terms for Malignant Struma Ovarii

Biological processes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.56 NCOA4 NKX2-1 PTCH1 RET
2 ERBB2 signaling pathway GO:0038128 9.32 HRAS NRAS
3 thyroid gland development GO:0030878 9.16 NKX2-1 TG
4 animal organ morphogenesis GO:0009887 9.13 HRAS NKX2-1 PTCH1
5 axon guidance GO:0007411 8.92 HRAS NKX2-1 NRAS RET

Molecular functions related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein complex binding GO:0032403 8.8 KRT19 NRAS PTCH1

Sources for Malignant Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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