MCID: MLG059
MIFTS: 36

Malignant Struma Ovarii malady

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Malignant Struma Ovarii

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Aliases & Descriptions for Malignant Struma Ovarii:

Name: Malignant Struma Ovarii 11 13
 
Struma Ovarii, Malignant 11 68

Classifications:



External Ids:

Disease Ontology11 DOID:5208
SNOMED-CT62 18854008
NCIt45 C4291

Summaries for Malignant Struma Ovarii

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MalaCards based summary: Malignant Struma Ovarii, also known as struma ovarii, malignant, is related to struma ovarii and thyroiditis. An important gene associated with Malignant Struma Ovarii is TG (Thyroglobulin), and among its related pathways are Signaling events regulated by Ret tyrosine kinase and G-protein signaling_H-RAS regulation pathway. Affiliated tissues include thyroid, liver and ovary, and related mouse phenotypes are Decreased shRNA abundance (Z-score < -2) and respiratory system.

Related Diseases for Malignant Struma Ovarii

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Diseases in the Struma Ovarii family:

malignant struma ovarii Benign Struma Ovarii

Diseases related to Malignant Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1struma ovarii10.9
2thyroiditis10.5
3chromophil adenoma of the kidney10.2NKX2-1, TG
4graves' disease10.2
5thyroid cancer10.2
6hirschsprung disease 110.2PTCH1, RET
7tmem70 defect10.1NKX2-1, RET, TG
8cowden syndrome 310.1RET, TG
9parachordoma10.1NKX2-1, RET, TG
10sphenoid sinus squamous cell carcinoma10.1AFP, NKX2-1
11neutropenia, severe congenital, 5, autosomal recessive10.1NKX2-1, RET, TG
12coloboma, ocular, autosomal recessive10.1HRAS, NKX2-1
13erythrocyte lactate transporter defect10.1HRAS, NRAS
14melanocytic nevus syndrome, congenital, somatic10.1HRAS, NRAS
15eccrine papillary adenoma10.1AFP, KRT19
16parotid gland adenoid cystic carcinoma10.1HRAS, NRAS
17nodular prostate10.1LGALS3, RET, TG
18tubulointerstitial nephritis with uveitis10.1HRAS, NRAS
19papillary carcinoma10.1
20teratoma10.1
21peritonitis10.1
22neuronopathy, distal hereditary motor, type viia10.1LGALS3, NKX2-1, TG
23vulval paget's disease10.1HRAS, NRAS
24kidney clear cell sarcoma10.1HRAS, NKX2-1
25nephrolithiasis10.1HRAS, NRAS
26gallbladder pleomorphic giant cell adenocarcinoma10.1HRAS, NRAS
27kidney disease10.1AFP, NKX2-1, TG
28adult epithelioid sarcoma10.1HRAS, NRAS
29neurocutaneous melanosis, somatic10.0HRAS, NRAS
30cranial nerve disease10.0AFP, NKX2-1
31exanthema subitum10.0HRAS, NKX2-1, TG
32papillary adenofibroma10.0HRAS, KRT19
33alpha chain disease10.0HRAS, NRAS, PTCH1
34non-syndromic male infertility due to sperm motility disorder10.0HRAS, RET
35gastrinoma9.9AFP, NKX2-1, RET, TG
36cervicitis9.9
37adenocarcinoma9.9
38cerebritis9.9
39meige syndrome9.9
40pseudo-meigs syndrome9.9
41progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 39.9HRAS, LGALS3, NRAS
42ossifying fibromyxoid tumor9.9HRAS, KRT19, NRAS
43arthus reaction9.9AFP, HRAS
44t-cell adult acute lymphocytic leukemia9.9NCOA4, PTCH1, RET
45small cell carcinoma9.9AFP, NKX2-1
46acute hemorrhagic encephalitis9.9HRAS, NRAS, RET, TG
47diabetes mellitus, insulin-dependent, 129.9KRT19, LGALS3, RET, TG
48basophilic carcinoma9.9AFP, HRAS, KRT19
49proctitis9.8AFP, HRAS, KRT19
50ocular melanoma9.8HRAS, KRT19, PTCH1

Graphical network of the top 20 diseases related to Malignant Struma Ovarii:



Diseases related to malignant struma ovarii

Symptoms & Phenotypes for Malignant Struma Ovarii

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GenomeRNAi Phenotypes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-849.2HRAS, NRAS, RET

MGI Mouse Phenotypes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

41 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6HRAS, LGALS3, NKX2-1, PTCH1, RET
2MP:00053898.4AFP, KRT19, LGALS3, NKX2-1, PTCH1, RET
3MP:00053818.3KRT19, LGALS3, NKX2-1, NRAS, PTCH1, RET
4MP:00028738.1HRAS, KRT19, NKX2-1, NRAS, PTCH1, RET
5MP:00030128.0HRAS, KRT19, NKX2-1, NRAS, PTCH1, RET
6MP:00053867.8AFP, HRAS, LGALS3, NKX2-1, NRAS, PTCH1
7MP:00053857.7HRAS, KRT19, LGALS3, NKX2-1, NRAS, PTCH1
8MP:00036317.7HRAS, KRT19, LGALS3, NKX2-1, PTCH1, RET
9MP:00053847.5KRT19, LGALS3, NCOA4, NKX2-1, NRAS, PTCH1
10MP:00020067.4AFP, HRAS, KRT19, LGALS3, NKX2-1, NRAS
11MP:00053797.3AFP, HRAS, KRT19, NKX2-1, NRAS, PTCH1
12MP:00107687.2AFP, HRAS, KRT19, LGALS3, NKX2-1, NRAS
13MP:00053766.7AFP, HRAS, LGALS3, NCOA4, NKX2-1, NRAS

Drugs & Therapeutics for Malignant Struma Ovarii

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Drugs for Malignant Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Hormones, Hormone Substitutes, and Hormone Antagonists13168
2Hormones14415
3Hormone Antagonists13180

Interventional clinical trials:

idNameStatusNCT IDPhase
1Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer TreatmentCompletedNCT01441154

Search NIH Clinical Center for Malignant Struma Ovarii

Genetic Tests for Malignant Struma Ovarii

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Anatomical Context for Malignant Struma Ovarii

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MalaCards organs/tissues related to Malignant Struma Ovarii:

36
Thyroid, Liver, Ovary, Bone, Eye

Publications for Malignant Struma Ovarii

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Articles related to Malignant Struma Ovarii:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Treatment and follow-up of malignant struma ovarii: Regarding two cases. (27355004)
2016
2
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. (27224256)
2016
3
A Hormonally Active Malignant Struma Ovarii. (27882257)
2016
4
Sincronous malignant struma ovarii and papillary thyroid carcinoma. (27297016)
2016
5
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. (27843812)
2016
6
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. (27566096)
2016
7
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. (26791568)
2016
8
Management dilemma of thyroid nodules in patients with malignant struma ovarii. (27563566)
2016
9
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. (26262453)
2015
10
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. (26630220)
2015
11
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. (25474425)
2014
12
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. (25375817)
2014
13
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. (24152665)
2014
14
The lack of consensus in management of malignant struma ovarii. (25539066)
2014
15
Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: A case report. (25364407)
2014
16
Two cases of malignant struma ovarii with metastasis to pelvic bone. (23391779)
2013
17
Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. (24217901)
2013
18
Synchronous papillary carcinoma thyroid with malignant struma ovarii: A management dilemma. (24379539)
2013
19
Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. (22288964)
2012
20
Malignant struma ovarii: the west of Scotland experience and review of literature with focus on postoperative management. (22883659)
2012
21
Laparoscopic excision of malignant struma ovarii and 1 year follow-up without further treatment. (21269611)
2011
22
Unilateral malignant struma ovarii in a case of bilateral ovarian teratoma with raised CA-125 level: a rare case with treatment dilemmas. (21934226)
2011
23
Metastatic malignant struma ovarii. (21598816)
2011
24
Unusual characteristics and fatal outcome of a malignant struma ovarii. Case report and literature review. (21531638)
2011
25
Malignant struma ovarii complicated by Trousseau's syndrome and repeated episodes of cerebral ischemic strokes: A case report. (24371609)
2011
26
Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread. (20407319)
2010
27
Metastasis of malignant struma ovarii to the lumbar spine. (20036545)
2010
28
Malignant struma ovarii. (20375218)
2010
29
Malignant struma ovarii: a case report. (20119594)
2010
30
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. (19772400)
2009
31
Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. (19696610)
2009
32
Malignant struma ovarii--a case report and review of the literature. (17890867)
2008
33
Malignant struma ovarii. (18560398)
2008
34
Malignant struma ovarii: good response after thyroidectomy and I ablation therapy. (21892277)
2008
35
An unusual variant of malignant struma ovarii. (18678124)
2008
36
Malignant struma ovarii with a focus of papillary thyroid cancer: a case report. (17882443)
2008
37
Malignant struma ovarii demonstrated on post-therapy radioiodine scan after total thyroidectomy for papillary thyroid cancer. (18496456)
2008
38
BRAF T1799A mutation occurring in a case of malignant struma ovarii. (17478764)
2007
39
Malignant struma ovarii: a case report and review of the literature. (17646728)
2007
40
Malignant struma ovarii: a case report. (16047952)
2005
41
Malignant struma ovarii with peritoneal implants and pelvic structures and liver metastases demonstrated by I-131 SPECT and low-dose CT. (16319636)
2005
42
Is the I-131 whole-body scanning proper for follow-up management of the patients with malignant struma ovarii without performing the thyroidectomy? (15963556)
2005
43
Malignant struma ovarii mimic clear cell carcinoma. (14986024)
2005
44
Malignant struma ovarii: a case report and review of the literature. (15166470)
2004
45
Case report: Malignant struma ovarii. (15038677)
2004
46
Pseudo-Meigs' syndrome associated with malignant struma ovarii: a case report. (15262148)
2004
47
Pregnancy following treated malignant struma ovarii. (15524228)
2004
48
Malignant struma ovarii: a case report of laparoscopic management. (12821363)
2003
49
Malignant struma ovarii: a case report and analysis of cases reported in the literature with focus on survival and I131 therapy. (12798728)
2003
50
Malignant struma ovarii. (12172581)
2002

Variations for Malignant Struma Ovarii

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Expression for genes affiliated with Malignant Struma Ovarii

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Search GEO for disease gene expression data for Malignant Struma Ovarii.

Pathways for genes affiliated with Malignant Struma Ovarii

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Pathways related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathwaysScoreTop Affiliating Genes
19.5HRAS, RET
29.5HRAS, RET
3
Show member pathways
9.5HRAS, NRAS
49.5HRAS, NRAS
59.5HRAS, NRAS
6
Show member pathways
9.5HRAS, NRAS
79.5HRAS, NRAS
89.5HRAS, NRAS
99.5HRAS, NRAS
109.5HRAS, NRAS
119.5HRAS, NRAS
12
Show member pathways
9.2HRAS, NRAS, RET
139.2HRAS, NRAS, RET
14
Show member pathways
9.2HRAS, NRAS, RET
159.2HRAS, NRAS, RET
16
Show member pathways
9.1HRAS, NRAS, PTCH1
179.1HRAS, NRAS, PTCH1
189.1HRAS, NRAS, PTCH1
198.3HRAS, NCOA4, NRAS, RET
207.9HRAS, NCOA4, NRAS, PTCH1, RET

GO Terms for genes affiliated with Malignant Struma Ovarii

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Biological processes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ERBB2 signaling pathwayGO:003812810.1HRAS, NRAS
2thyroid gland developmentGO:00308789.8NKX2-1, TG
3animal organ morphogenesisGO:00098879.8HRAS, NKX2-1, PTCH1
4axon guidanceGO:00074119.5HRAS, NKX2-1, NRAS, RET
5positive regulation of transcription, DNA-templatedGO:00458939.0NCOA4, NKX2-1, PTCH1, RET

Molecular functions related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:00324039.2KRT19, NRAS, PTCH1

Sources for Malignant Struma Ovarii

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet