MCID: MLG059
MIFTS: 35

Malignant Struma Ovarii malady

Category: Cancer diseases

Aliases & Classifications for Malignant Struma Ovarii

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Aliases & Descriptions for Malignant Struma Ovarii:

Name: Malignant Struma Ovarii 11 13
 
Struma Ovarii, Malignant 11 68

Classifications:



External Ids:

Disease Ontology11 DOID:5208
SNOMED-CT62 18854008
NCIt45 C4291

Summaries for Malignant Struma Ovarii

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MalaCards based summary: Malignant Struma Ovarii, also known as struma ovarii, malignant, is related to struma ovarii and thyroid hormonogenesis defect i. An important gene associated with Malignant Struma Ovarii is TG (Thyroglobulin), and among its related pathways are G-protein signaling_H-RAS regulation pathway and Signaling events regulated by Ret tyrosine kinase. Affiliated tissues include thyroid, liver and ovary, and related mouse phenotypes are Decreased shRNA abundance (Z-score < -2) and respiratory system.

Related Diseases for Malignant Struma Ovarii

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Diseases in the Struma Ovarii family:

malignant struma ovarii Benign Struma Ovarii

Diseases related to Malignant Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1struma ovarii10.9
2thyroid hormonogenesis defect i10.5RET, TG
3transient hypogammaglobulinemia of infancy10.5NKX2-1, TG
4thyroiditis10.5
5substernal goiter10.3LGALS3, TG
6large cell keratinizing variant squamous cell breast carcinoma10.3AFP, NKX2-1
7sphenoidal sinus cancer10.3AFP, NKX2-1
8localized pulmonary fibrosis10.3AFP, NKX2-1
9benign mesothelioma10.3NKX2-1, RET, TG
10medullary thyroid carcinoma, familial10.2NKX2-1, RET, TG
11retinitis pigmentosa 2710.2HRAS, NKX2-1
12melanocytic nevus syndrome, congenital, somatic10.2HRAS, NRAS
13sublingual gland adenoid cystic carcinoma10.2HRAS, NRAS
14epidermal nevus, somatic10.2HRAS, NRAS
15trachea adenoid cystic carcinoma10.2HRAS, NKX2-1
16graves' disease10.2
17thyroid cancer10.2
18schimmelpenning-feuerstein-mims syndrome, somatic mosaic10.2HRAS, NRAS
19coloboma of macula and skeletal anomalies10.2HRAS, NRAS
20bladder calculus10.2LGALS3, RET
21psammomatous meningioma10.2HRAS, NRAS
22papillary hidradenoma10.2AFP, KRT19
23spindle cell synovial sarcoma10.2AFP, TG
24sporadic secreting paraganglioma10.1HRAS, RET
25neonatal stroke10.1HRAS, NRAS
26hashimoto thyroiditis10.1LGALS3, RET, TG
27hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.1LGALS3, NKX2-1, TG
28vulvar sarcoma10.1HRAS, NRAS
29dermatosis papulosa nigra10.1HRAS, NRAS
30papillary carcinoma10.1
31teratoma10.1
32peritonitis10.1
33adenosquamous carcinoma10.1HRAS, RET
34adult teratoma10.1AFP, NKX2-1, TG
35critical congenital heart disease10.1HRAS, NRAS
36perineocele10.0AFP, RET
37esophagus leiomyosarcoma10.0HRAS, NRAS
38small cell sarcoma10.0AFP, TG
39meningovascular neurosyphilis10.0HRAS, NKX2-1, TG
40ovarian serous adenofibroma10.0HRAS, KRT19
41vibratory urticaria10.0AFP, HRAS
42spindle cell hemangioma9.9HRAS, NRAS
43aneruptive fever9.9NCOA4, NKX2-1
44epilepsy with generalized tonic-clonic seizures9.9HRAS, KRT19
45cervicitis9.9
46adenocarcinoma9.9
47cerebritis9.9
48meige syndrome9.9
49pseudo-meigs syndrome9.9
502-hydroxyethyl methacrylate sensitization9.9AFP, RET

Graphical network of the top 20 diseases related to Malignant Struma Ovarii:



Diseases related to malignant struma ovarii

Symptoms & Phenotypes for Malignant Struma Ovarii

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GenomeRNAi Phenotypes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-589.2HRAS, NRAS, RET

MGI Mouse Phenotypes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

41 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7HRAS, LGALS3, NKX2-1, PTCH1, RET
2MP:00053898.3AFP, KRT19, LGALS3, NKX2-1, PTCH1, RET
3MP:00030128.2HRAS, KRT19, NKX2-1, NRAS, PTCH1, RET
4MP:00028738.1HRAS, KRT19, NKX2-1, NRAS, PTCH1, RET
5MP:00053817.9KRT19, LGALS3, NKX2-1, NRAS, PTCH1, RET
6MP:00036317.6HRAS, KRT19, LGALS3, NKX2-1, PTCH1, RET
7MP:00053867.6AFP, HRAS, LGALS3, NKX2-1, NRAS, PTCH1
8MP:00053847.5KRT19, LGALS3, NCOA4, NKX2-1, NRAS, PTCH1
9MP:00053797.4AFP, HRAS, KRT19, NKX2-1, NRAS, PTCH1
10MP:00053857.4HRAS, KRT19, LGALS3, NKX2-1, NRAS, PTCH1
11MP:00020067.3AFP, HRAS, KRT19, LGALS3, NKX2-1, NRAS
12MP:00107687.1AFP, HRAS, KRT19, LGALS3, NKX2-1, NRAS
13MP:00053766.4AFP, HRAS, LGALS3, NCOA4, NKX2-1, NRAS

Drugs & Therapeutics for Malignant Struma Ovarii

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Drugs for Malignant Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Hormones, Hormone Substitutes, and Hormone Antagonists12767
2Hormones13979
3Hormone Antagonists12778

Interventional clinical trials:

idNameStatusNCT IDPhase
1Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer TreatmentCompletedNCT01441154

Search NIH Clinical Center for Malignant Struma Ovarii

Genetic Tests for Malignant Struma Ovarii

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Anatomical Context for Malignant Struma Ovarii

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MalaCards organs/tissues related to Malignant Struma Ovarii:

36
Thyroid, Liver, Ovary, Bone, Eye

Publications for Malignant Struma Ovarii

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Articles related to Malignant Struma Ovarii:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. (27843812)
2016
2
Sincronous malignant struma ovarii and papillary thyroid carcinoma. (27297016)
2016
3
Treatment and follow-up of malignant struma ovarii: Regarding two cases. (27355004)
2016
4
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. (26791568)
2016
5
A Hormonally Active Malignant Struma Ovarii. (27882257)
2016
6
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. (27224256)
2016
7
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. (27566096)
2016
8
Management dilemma of thyroid nodules in patients with malignant struma ovarii. (27563566)
2016
9
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. (26630220)
2015
10
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. (26262453)
2015
11
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. (24152665)
2014
12
Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: A case report. (25364407)
2014
13
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. (25474425)
2014
14
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. (25375817)
2014
15
The lack of consensus in management of malignant struma ovarii. (25539066)
2014
16
Two cases of malignant struma ovarii with metastasis to pelvic bone. (23391779)
2013
17
Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. (24217901)
2013
18
Synchronous papillary carcinoma thyroid with malignant struma ovarii: A management dilemma. (24379539)
2013
19
Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. (22288964)
2012
20
Malignant struma ovarii: the west of Scotland experience and review of literature with focus on postoperative management. (22883659)
2012
21
Metastatic malignant struma ovarii. (21598816)
2011
22
Malignant struma ovarii complicated by Trousseau's syndrome and repeated episodes of cerebral ischemic strokes: A case report. (24371609)
2011
23
Unilateral malignant struma ovarii in a case of bilateral ovarian teratoma with raised CA-125 level: a rare case with treatment dilemmas. (21934226)
2011
24
Unusual characteristics and fatal outcome of a malignant struma ovarii. Case report and literature review. (21531638)
2011
25
Laparoscopic excision of malignant struma ovarii and 1 year follow-up without further treatment. (21269611)
2011
26
Malignant struma ovarii. (20375218)
2010
27
Malignant struma ovarii: a case report. (20119594)
2010
28
Metastasis of malignant struma ovarii to the lumbar spine. (20036545)
2010
29
Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread. (20407319)
2010
30
Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. (19696610)
2009
31
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. (19772400)
2009
32
Malignant struma ovarii. (18560398)
2008
33
An unusual variant of malignant struma ovarii. (18678124)
2008
34
Malignant struma ovarii demonstrated on post-therapy radioiodine scan after total thyroidectomy for papillary thyroid cancer. (18496456)
2008
35
Malignant struma ovarii--a case report and review of the literature. (17890867)
2008
36
Malignant struma ovarii with a focus of papillary thyroid cancer: a case report. (17882443)
2008
37
Malignant struma ovarii: good response after thyroidectomy and I ablation therapy. (21892277)
2008
38
BRAF T1799A mutation occurring in a case of malignant struma ovarii. (17478764)
2007
39
Malignant struma ovarii: a case report and review of the literature. (17646728)
2007
40
Malignant struma ovarii mimic clear cell carcinoma. (14986024)
2005
41
Is the I-131 whole-body scanning proper for follow-up management of the patients with malignant struma ovarii without performing the thyroidectomy? (15963556)
2005
42
Malignant struma ovarii with peritoneal implants and pelvic structures and liver metastases demonstrated by I-131 SPECT and low-dose CT. (16319636)
2005
43
Malignant struma ovarii: a case report. (16047952)
2005
44
Pseudo-Meigs' syndrome associated with malignant struma ovarii: a case report. (15262148)
2004
45
Pregnancy following treated malignant struma ovarii. (15524228)
2004
46
Case report: Malignant struma ovarii. (15038677)
2004
47
Malignant struma ovarii: a case report and review of the literature. (15166470)
2004
48
Malignant struma ovarii: a case report and analysis of cases reported in the literature with focus on survival and I131 therapy. (12798728)
2003
49
Malignant struma ovarii: a case report of laparoscopic management. (12821363)
2003
50
Conservative therapy for malignant struma ovarii. A case report. (12497687)
2002

Variations for Malignant Struma Ovarii

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Expression for genes affiliated with Malignant Struma Ovarii

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Search GEO for disease gene expression data for Malignant Struma Ovarii.

Pathways for genes affiliated with Malignant Struma Ovarii

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GO Terms for genes affiliated with Malignant Struma Ovarii

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Biological processes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ERBB2 signaling pathwayGO:003812810.2HRAS, NRAS
2thyroid gland developmentGO:00308789.8NKX2-1, TG
3axon guidanceGO:00074119.8HRAS, NKX2-1, NRAS
4MAPK cascadeGO:00001659.8HRAS, NRAS, RET
5animal organ morphogenesisGO:00098879.8HRAS, NKX2-1, PTCH1
6positive regulation of transcription, DNA-templatedGO:00458939.0NCOA4, NKX2-1, PTCH1, RET

Molecular functions related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:00324038.9KRT19, NRAS, PTCH1, TG

Sources for Malignant Struma Ovarii

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet