MCID: MLG059
MIFTS: 36

Malignant Struma Ovarii malady

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Malignant Struma Ovarii

Aliases & Descriptions for Malignant Struma Ovarii:

Name: Malignant Struma Ovarii 12 14
Struma Ovarii, Malignant 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5208
NCIt 47 C4291
SNOMED-CT 64 18854008
UMLS 69 C0334525

Summaries for Malignant Struma Ovarii

MalaCards based summary : Malignant Struma Ovarii, also known as struma ovarii, malignant, is related to struma ovarii and thyroiditis. An important gene associated with Malignant Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways and Proteoglycans in cancer. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, liver and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and homeostasis/metabolism

Related Diseases for Malignant Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Malignant Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Related Disease Score Top Affiliating Genes
1 struma ovarii 10.9
2 thyroiditis 10.5
3 chromophil adenoma of the kidney 10.2 NKX2-1 TG
4 graves' disease 10.2
5 thyroid cancer 10.2
6 hirschsprung disease 1 10.2 PTCH1 RET
7 tmem70 defect 10.1 NKX2-1 RET TG
8 cowden syndrome 3 10.1 RET TG
9 parachordoma 10.1 NKX2-1 RET TG
10 sphenoid sinus squamous cell carcinoma 10.1 AFP NKX2-1
11 neutropenia, severe congenital, 5, autosomal recessive 10.1 NKX2-1 RET TG
12 coloboma, ocular, autosomal recessive 10.1 HRAS NKX2-1
13 erythrocyte lactate transporter defect 10.1 HRAS NRAS
14 melanocytic nevus syndrome, congenital, somatic 10.1 HRAS NRAS
15 eccrine papillary adenoma 10.1 AFP KRT19
16 parotid gland adenoid cystic carcinoma 10.1 HRAS NRAS
17 nodular prostate 10.1 LGALS3 RET TG
18 tubulointerstitial nephritis with uveitis 10.1 HRAS NRAS
19 papillary carcinoma 10.1
20 teratoma 10.1
21 peritonitis 10.1
22 neuronopathy, distal hereditary motor, type viia 10.1 LGALS3 NKX2-1 TG
23 vulval paget's disease 10.1 HRAS NRAS
24 kidney clear cell sarcoma 10.1 HRAS NKX2-1
25 nephrolithiasis 10.1 HRAS NRAS
26 gallbladder pleomorphic giant cell adenocarcinoma 10.1 HRAS NRAS
27 kidney disease 10.1 AFP NKX2-1 TG
28 adult epithelioid sarcoma 10.1 HRAS NRAS
29 neurocutaneous melanosis, somatic 10.0 HRAS NRAS
30 cranial nerve disease 10.0 AFP NKX2-1
31 exanthema subitum 10.0 HRAS NKX2-1 TG
32 papillary adenofibroma 10.0 HRAS KRT19
33 alpha chain disease 10.0 HRAS NRAS PTCH1
34 non-syndromic male infertility due to sperm motility disorder 10.0 HRAS RET
35 gastrinoma 9.9 AFP NKX2-1 RET TG
36 cervicitis 9.9
37 adenocarcinoma 9.9
38 cerebritis 9.9
39 meige syndrome 9.9
40 pseudo-meigs syndrome 9.9
41 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 3 9.9 HRAS LGALS3 NRAS
42 ossifying fibromyxoid tumor 9.9 HRAS KRT19 NRAS
43 arthus reaction 9.9 AFP HRAS
44 t-cell adult acute lymphocytic leukemia 9.9 NCOA4 PTCH1 RET
45 small cell carcinoma 9.9 AFP NKX2-1
46 acute hemorrhagic encephalitis 9.9 HRAS NRAS RET TG
47 diabetes mellitus, insulin-dependent, 12 9.9 KRT19 LGALS3 RET TG
48 basophilic carcinoma 9.9 AFP HRAS KRT19
49 proctitis 9.8 AFP HRAS KRT19
50 ocular melanoma 9.8 HRAS KRT19 PTCH1

Graphical network of the top 20 diseases related to Malignant Struma Ovarii:



Diseases related to Malignant Struma Ovarii

Symptoms & Phenotypes for Malignant Struma Ovarii

GenomeRNAi Phenotypes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.4 NRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.4 RET
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.4 NRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.4 RET
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.4 RET HRAS NRAS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.4 RET
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 HRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 NRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.4 HRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.4 HRAS

MGI Mouse Phenotypes related to Malignant Struma Ovarii:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.09 AFP HRAS LGALS3 NCOA4 NKX2-1 NRAS
2 behavior/neurological MP:0005386 10.07 AFP HRAS LGALS3 NKX2-1 NRAS PTCH1
3 endocrine/exocrine gland MP:0005379 10.06 KRT19 NKX2-1 NRAS PTCH1 RET TG
4 cardiovascular system MP:0005385 10.05 KRT19 LGALS3 NKX2-1 NRAS PTCH1 RET
5 cellular MP:0005384 10.04 KRT19 LGALS3 NCOA4 NKX2-1 NRAS PTCH1
6 mortality/aging MP:0010768 10.01 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1
7 neoplasm MP:0002006 9.97 AFP HRAS KRT19 LGALS3 NKX2-1 NRAS
8 digestive/alimentary MP:0005381 9.95 KRT19 LGALS3 NKX2-1 NRAS PTCH1 RET
9 nervous system MP:0003631 9.87 HRAS KRT19 LGALS3 NKX2-1 PTCH1 RET
10 no phenotypic analysis MP:0003012 9.73 HRAS KRT19 NKX2-1 NRAS PTCH1 RET
11 normal MP:0002873 9.63 HRAS KRT19 NKX2-1 NRAS PTCH1 RET
12 reproductive system MP:0005389 9.43 AFP KRT19 LGALS3 NKX2-1 PTCH1 RET
13 respiratory system MP:0005388 9.02 HRAS LGALS3 NKX2-1 PTCH1 RET

Drugs & Therapeutics for Malignant Struma Ovarii

Drugs for Malignant Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists
2 Hormones
3 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


id Name Status NCT ID Phase
1 Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment Completed NCT01441154

Search NIH Clinical Center for Malignant Struma Ovarii

Genetic Tests for Malignant Struma Ovarii

Anatomical Context for Malignant Struma Ovarii

MalaCards organs/tissues related to Malignant Struma Ovarii:

39
Thyroid, Liver, Bone, Eye, Ovary

Publications for Malignant Struma Ovarii

Articles related to Malignant Struma Ovarii:

(show top 50) (show all 80)
id Title Authors Year
1
Treatment and follow-up of malignant struma ovarii: Regarding two cases. ( 27355004 )
2016
2
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. ( 27224256 )
2016
3
A Hormonally Active Malignant Struma Ovarii. ( 27882257 )
2016
4
Sincronous malignant struma ovarii and papillary thyroid carcinoma. ( 27297016 )
2016
5
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. ( 27843812 )
2016
6
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. ( 27566096 )
2016
7
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. ( 26791568 )
2016
8
Management dilemma of thyroid nodules in patients with malignant struma ovarii. ( 27563566 )
2016
9
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. ( 26262453 )
2015
10
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. ( 26630220 )
2015
11
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. ( 25474425 )
2014
12
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. ( 25375817 )
2014
13
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. ( 24152665 )
2014
14
The lack of consensus in management of malignant struma ovarii. ( 25539066 )
2014
15
Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: A case report. ( 25364407 )
2014
16
Two cases of malignant struma ovarii with metastasis to pelvic bone. ( 23391779 )
2013
17
Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. ( 24217901 )
2013
18
Synchronous papillary carcinoma thyroid with malignant struma ovarii: A management dilemma. ( 24379539 )
2013
19
Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. ( 22288964 )
2012
20
Malignant struma ovarii: the west of Scotland experience and review of literature with focus on postoperative management. ( 22883659 )
2012
21
Laparoscopic excision of malignant struma ovarii and 1 year follow-up without further treatment. ( 21269611 )
2011
22
Unilateral malignant struma ovarii in a case of bilateral ovarian teratoma with raised CA-125 level: a rare case with treatment dilemmas. ( 21934226 )
2011
23
Metastatic malignant struma ovarii. ( 21598816 )
2011
24
Unusual characteristics and fatal outcome of a malignant struma ovarii. Case report and literature review. ( 21531638 )
2011
25
Malignant struma ovarii complicated by Trousseau's syndrome and repeated episodes of cerebral ischemic strokes: A case report. ( 24371609 )
2011
26
Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread. ( 20407319 )
2010
27
Metastasis of malignant struma ovarii to the lumbar spine. ( 20036545 )
2010
28
Malignant struma ovarii. ( 20375218 )
2010
29
Malignant struma ovarii: a case report. ( 20119594 )
2010
30
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. ( 19772400 )
2009
31
Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. ( 19696610 )
2009
32
Malignant struma ovarii--a case report and review of the literature. ( 17890867 )
2008
33
Malignant struma ovarii. ( 18560398 )
2008
34
Malignant struma ovarii: good response after thyroidectomy and I ablation therapy. ( 21892277 )
2008
35
An unusual variant of malignant struma ovarii. ( 18678124 )
2008
36
Malignant struma ovarii with a focus of papillary thyroid cancer: a case report. ( 17882443 )
2008
37
Malignant struma ovarii demonstrated on post-therapy radioiodine scan after total thyroidectomy for papillary thyroid cancer. ( 18496456 )
2008
38
BRAF T1799A mutation occurring in a case of malignant struma ovarii. ( 17478764 )
2007
39
Malignant struma ovarii: a case report and review of the literature. ( 17646728 )
2007
40
Malignant struma ovarii: a case report. ( 16047952 )
2005
41
Malignant struma ovarii with peritoneal implants and pelvic structures and liver metastases demonstrated by I-131 SPECT and low-dose CT. ( 16319636 )
2005
42
Is the I-131 whole-body scanning proper for follow-up management of the patients with malignant struma ovarii without performing the thyroidectomy? ( 15963556 )
2005
43
Malignant struma ovarii mimic clear cell carcinoma. ( 14986024 )
2005
44
Malignant struma ovarii: a case report and review of the literature. ( 15166470 )
2004
45
Case report: Malignant struma ovarii. ( 15038677 )
2004
46
Pseudo-Meigs' syndrome associated with malignant struma ovarii: a case report. ( 15262148 )
2004
47
Pregnancy following treated malignant struma ovarii. ( 15524228 )
2004
48
Malignant struma ovarii: a case report of laparoscopic management. ( 12821363 )
2003
49
Malignant struma ovarii: a case report and analysis of cases reported in the literature with focus on survival and I131 therapy. ( 12798728 )
2003
50
Malignant struma ovarii. ( 12172581 )
2002

Variations for Malignant Struma Ovarii

Expression for Malignant Struma Ovarii

Search GEO for disease gene expression data for Malignant Struma Ovarii.

Pathways for Malignant Struma Ovarii

Pathways related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.11 HRAS NRAS PTCH1
2 12.04 HRAS NRAS PTCH1
3 11.95 HRAS NCOA4 NRAS PTCH1 RET
4 11.91 HRAS NRAS PTCH1
5
Show member pathways
11.86 HRAS NRAS RET
6
Show member pathways
11.42 HRAS NRAS RET
7 11.25 HRAS NRAS RET
8 11.16 HRAS RET
9 11.16 HRAS RET
10 11.1 HRAS NRAS
11 11.02 HRAS NRAS
12 11.01 HRAS NRAS
13 11.01 HRAS NRAS RET
14
Show member pathways
10.99 HRAS NRAS
15
Show member pathways
10.93 HRAS NRAS
16 10.84 HRAS NRAS
17 10.78 HRAS NRAS
18 10.71 HRAS NRAS
19 10.48 HRAS NRAS
20 10.39 HRAS NCOA4 NRAS RET

GO Terms for Malignant Struma Ovarii

Biological processes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.56 NCOA4 NKX2-1 PTCH1 RET
2 ERBB2 signaling pathway GO:0038128 9.32 HRAS NRAS
3 thyroid gland development GO:0030878 9.16 NKX2-1 TG
4 animal organ morphogenesis GO:0009887 9.13 HRAS NKX2-1 PTCH1
5 axon guidance GO:0007411 8.92 HRAS NKX2-1 NRAS RET

Molecular functions related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex binding GO:0032403 8.8 KRT19 NRAS PTCH1

Sources for Malignant Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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