MCID: MLG059
MIFTS: 33

Malignant Struma Ovarii malady

Category: Cancer diseases

Aliases & Classifications for Malignant Struma Ovarii

About this section

Aliases & Descriptions for Malignant Struma Ovarii:

Name: Malignant Struma Ovarii 11 13
 
Struma Ovarii, Malignant 11 66

Classifications:



External Ids:

Disease Ontology11 DOID:5208
SNOMED-CT60 18854008
NCIt43 C4291

Summaries for Malignant Struma Ovarii

About this section
MalaCards based summary: Malignant Struma Ovarii, also known as struma ovarii, malignant, is related to struma ovarii and thyroiditis. An important gene associated with Malignant Struma Ovarii is TG (Thyroglobulin), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and G-protein signaling_H-RAS regulation pathway. Affiliated tissues include thyroid, liver and ovary, and related mouse phenotypes are digestive/alimentary and no phenotypic analysis.

Related Diseases for Malignant Struma Ovarii

About this section

Diseases in the Struma Ovarii family:

malignant struma ovarii Benign Struma Ovarii

Diseases related to Malignant Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1struma ovarii11.0
2thyroiditis10.6
3thyroid hormonogenesis defect i10.5RET, TG
4transient hypogammaglobulinemia of infancy10.5NKX2-1, TG
5epididymal neoplasm10.4NKX2-1, TG
6substernal goiter10.3LGALS3, TG
7graves' disease10.3
8thyroid cancer10.3
9bladder calculus10.3LGALS3, RET
10large cell keratinizing variant squamous cell breast carcinoma10.2AFP, NKX2-1
11sphenoidal sinus cancer10.2AFP, NKX2-1
12papillary carcinoma10.2
13teratoma10.2
14localized pulmonary fibrosis10.2AFP, NKX2-1
15lung occult large cell carcinoma10.2RET, TG
16congenital bile acid synthesis defect10.2AFP, NKX2-1
17spindle cell synovial sarcoma10.2AFP, TG
18benign mesothelioma10.2NKX2-1, RET, TG
19medullary thyroid carcinoma, familial10.2NKX2-1, RET, TG
20papillary hidradenoma10.1AFP, KRT19
21small cell sarcoma10.1AFP, TG
22perineocele10.1AFP, RET
23primary bacterial infectious disease10.1NKX2-1, TG
242-hydroxyethyl methacrylate sensitization10.1AFP, RET
25cervicitis10.1
26adenocarcinoma10.1
27cerebritis10.1
28meige syndrome10.1
29peritonitis10.1
30pseudo-meigs syndrome10.1
31hashimoto thyroiditis10.1LGALS3, RET, TG
32retinitis pigmentosa 2710.0HRAS, NKX2-1
33hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.0LGALS3, NKX2-1, TG
34trachea adenoid cystic carcinoma10.0HRAS, NKX2-1
35sporadic secreting paraganglioma10.0HRAS, RET
36melanocytic nevus syndrome, congenital, somatic10.0HRAS, NRAS
37sublingual gland adenoid cystic carcinoma10.0HRAS, NRAS
38epidermal nevus, somatic10.0HRAS, NRAS
39schimmelpenning-feuerstein-mims syndrome, somatic mosaic10.0HRAS, NRAS
40coloboma of macula and skeletal anomalies10.0HRAS, NRAS
41adenosquamous carcinoma10.0HRAS, RET
42psammomatous meningioma10.0HRAS, NRAS
43neonatal stroke10.0HRAS, NRAS
44vulvar sarcoma10.0HRAS, NRAS
45dermatosis papulosa nigra10.0HRAS, NRAS
46melanoma9.9HRAS, NRAS
47adult teratoma9.9AFP, NKX2-1, TG
48critical congenital heart disease9.9HRAS, NRAS
49multiple spinal canal and spinal cord meningioma9.9AFP, KRT19
50esophagus leiomyosarcoma9.9HRAS, NRAS

Graphical network of the top 20 diseases related to Malignant Struma Ovarii:



Diseases related to malignant struma ovarii

Symptoms for Malignant Struma Ovarii

About this section

Drugs & Therapeutics for Malignant Struma Ovarii

About this section

Interventional clinical trials:

idNameStatusNCT IDPhase
1Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer TreatmentCompletedNCT01441154Phase 1

Search NIH Clinical Center for Malignant Struma Ovarii

Genetic Tests for Malignant Struma Ovarii

About this section

Anatomical Context for Malignant Struma Ovarii

About this section

MalaCards organs/tissues related to Malignant Struma Ovarii:

34
Thyroid, Liver, Ovary, Bone, Eye

Animal Models for Malignant Struma Ovarii or affiliated genes

About this section

MGI Mouse Phenotypes related to Malignant Struma Ovarii:

39 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5KRT19, LGALS3, NKX2-1, NRAS, RET
2MP:00030128.3HRAS, KRT19, NKX2-1, NRAS, RET
3MP:00028738.1HRAS, KRT19, NKX2-1, NRAS, RET
4MP:00036317.7HRAS, KRT19, LGALS3, NKX2-1, RET, TG
5MP:00053857.6HRAS, KRT19, LGALS3, NKX2-1, NRAS, RET
6MP:00053867.4AFP, HRAS, LGALS3, NKX2-1, NRAS, RET
7MP:00020067.1AFP, HRAS, KRT19, LGALS3, NKX2-1, NRAS
8MP:00053797.1AFP, HRAS, KRT19, NKX2-1, NRAS, RET
9MP:00053767.0AFP, HRAS, LGALS3, NKX2-1, NRAS, RET
10MP:00107687.0AFP, HRAS, KRT19, LGALS3, NKX2-1, NRAS

Publications for Malignant Struma Ovarii

About this section

Articles related to Malignant Struma Ovarii:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Sincronous malignant struma ovarii and papillary thyroid carcinoma. (27297016)
2016
2
Treatment and follow-up of malignant struma ovarii: Regarding two cases. (27355004)
2016
3
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. (26630220)
2015
4
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. (24152665)
2014
5
Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: A case report. (25364407)
2014
6
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. (25474425)
2014
7
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. (25375817)
2014
8
Two cases of malignant struma ovarii with metastasis to pelvic bone. (23391779)
2013
9
Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. (24217901)
2013
10
Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. (22288964)
2012
11
Metastatic malignant struma ovarii. (21598816)
2011
12
Malignant struma ovarii complicated by Trousseau's syndrome and repeated episodes of cerebral ischemic strokes: A case report. (24371609)
2011
13
Unilateral malignant struma ovarii in a case of bilateral ovarian teratoma with raised CA-125 level: a rare case with treatment dilemmas. (21934226)
2011
14
Malignant struma ovarii. (20375218)
2010
15
Malignant struma ovarii: a case report. (20119594)
2010
16
Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. (19696610)
2009
17
Malignant struma ovarii. (18560398)
2008
18
An unusual variant of malignant struma ovarii. (18678124)
2008
19
Malignant struma ovarii demonstrated on post-therapy radioiodine scan after total thyroidectomy for papillary thyroid cancer. (18496456)
2008
20
Malignant struma ovarii--a case report and review of the literature. (17890867)
2008
21
BRAF T1799A mutation occurring in a case of malignant struma ovarii. (17478764)
2007
22
Malignant struma ovarii: a case report and review of the literature. (17646728)
2007
23
Malignant struma ovarii mimic clear cell carcinoma. (14986024)
2005
24
Is the I-131 whole-body scanning proper for follow-up management of the patients with malignant struma ovarii without performing the thyroidectomy? (15963556)
2005
25
Pseudo-Meigs' syndrome associated with malignant struma ovarii: a case report. (15262148)
2004
26
Pregnancy following treated malignant struma ovarii. (15524228)
2004
27
Case report: Malignant struma ovarii. (15038677)
2004
28
Malignant struma ovarii: a case report and review of the literature. (15166470)
2004
29
Malignant struma ovarii: a case report and analysis of cases reported in the literature with focus on survival and I131 therapy. (12798728)
2003
30
Conservative therapy for malignant struma ovarii. A case report. (12497687)
2002
31
Malignant struma ovarii: report of a case and review of the literature. (12169779)
2002
32
Coexistence of malignant struma ovarii and Graves' disease. (15251841)
2002
33
Malignant struma ovarii: an unusual presentation. (11575860)
2001
34
Functioning liver metastases on an I-131 whole-body scan: a case of malignant struma ovarii. (10836696)
2000
35
Malignant struma ovarii: two case reports and a review of the literature. (10366477)
1999
36
Malignant struma ovarii: recurrence and response to treatment monitored by thyroglobulin levels. (9790800)
1998
37
Hashimoto's disease in a papillary carcinoma of the thyroid originating in a teratoma of the ovary (malignant struma ovarii). (9526709)
1998
38
Radiotherapy with iodine-131 in recurrent malignant struma ovarii. (9091289)
1997
39
Radiotherapy with iodine-131 in recurrent malignant struma ovarii. (8586108)
1996
40
Metastatic malignant struma ovarii. Two case reports. (1638839)
1992
41
Malignant struma ovarii: report of two cases and selected review of the literature. (2404159)
1990
42
Malignant struma ovarii: presentation and management. (2379061)
1990
43
Metastatic malignant struma ovarii presenting as paraparesis from a spinal metastasis. (2738669)
1989
44
Malignant struma ovarii. (2910784)
1989
45
Malignant struma ovarii treated by ovariectomy, thyroidectomy, and 131I administration. (3297279)
1987
46
Malignant struma ovarii, diagnosed post menopause. (6537645)
1984
47
Malignant struma ovarii. Light and electron microscopic study. (6821820)
1983
48
Malignant struma ovarii. A case report and literature review. (6887150)
1983
49
Malignant struma ovarii. (6628817)
1983
50
Malignant struma ovarii. (1004942)
1976

Variations for Malignant Struma Ovarii

About this section

Expression for genes affiliated with Malignant Struma Ovarii

About this section
Search GEO for disease gene expression data for Malignant Struma Ovarii.

Pathways for genes affiliated with Malignant Struma Ovarii

About this section

GO Terms for genes affiliated with Malignant Struma Ovarii

About this section

Biological processes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:003087810.2NKX2-1, TG
2ERBB2 signaling pathwayGO:00381289.5HRAS, NRAS
3epidermal growth factor receptor signaling pathwayGO:00071739.5HRAS, NRAS
4MAPK cascadeGO:00001659.0HRAS, NRAS, RET
5positive regulation of gene expressionGO:00106288.9HRAS, NKX2-1, RET
6axon guidanceGO:00074118.8HRAS, NKX2-1, NRAS

Molecular functions related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:00324039.2KRT19, NRAS, TG

Sources for Malignant Struma Ovarii

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet