MCID: MLG081
MIFTS: 46

Malignant Teratoma malady

Cancer diseases category

Summaries for Malignant Teratoma

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34MalaCards
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MalaCards: Malignant Teratoma, also known as primary malignant extragonadal teratoma, is related to teratoma and leukemia. An important gene associated with Malignant Teratoma is BAX (BCL2-associated X protein), and among its related pathways are Integrated Breast Cancer Pathway and TNF Signaling. The compounds bax channel blocker and mim1 have been mentioned in the context of this disorder. Affiliated tissues include testis, thyroid and ovary.

Aliases & Classifications for Malignant Teratoma

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9Disease Ontology, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

malignant teratoma 9
primary malignant extragonadal teratoma 9
teratoma, malignant, no icd-o subtype 9
malignant extragonadal teratoma 9
teratoma, malignant 63
immature teratoma 9


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Disease Ontology9 DOID:5563
NCIt41 C4286
SNOMED-CT59 19467007, 189847002
MeSH36 D013724

Related Diseases for Malignant Teratoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Malignant Teratoma family:

Intermediate Malignant Teratoma Adult Teratoma
Teratoma

Diseases related to Malignant Teratoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma31.7CGB5, CD99
2leukemia30.3BCL2, BAX, CD99
3adenocarcinoma29.9CGB5, BAX, BCL2
4myeloid leukemia29.9BAX, BCL2
5thyroiditis10.6
6gliomatosis peritonei10.5
7central nervous system immature teratoma10.4
8adult central nervous system immature teratoma10.3
9childhood immature teratoma of ovary10.3
10childhood central nervous system immature teratoma10.3
11pineal region immature teratoma10.3
12neuronitis10.3
13precocious puberty10.3
14mixed germ cell tumor10.3
15intermediate malignant teratoma10.3
16uterine inversion10.2
17encephalitis10.2
18polyembryoma10.2
19immature teratoma of ovary10.2
20mediastinitis10.2
21seminoma10.2
22sinusitis10.2
23klinefelter's syndrome10.1
24cervicitis10.1
25sarcoma10.1
26germ cell tumors10.1
27malignant histiocytosis10.1
28choroiditis10.1
29quadriplegia10.1
30clear cell adenocarcinoma10.1
31endodermal sinus tumor10.1
32endometrial adenocarcinoma10.1
33endometriosis10.1
34histiocytosis10.1
35malignant ependymoma10.1
36oligodendroglioma10.1
37ovarian embryonal carcinoma10.1
38wilms tumor10.1
39ependymoma10.1
40limbic encephalitis10.1
41mayer-rokitansky-kuster-hauser syndrome10.1
42neuroepithelioma10.1
43lung cancer10.1BCL2
44laryngeal squamous cell carcinoma10.0BAX, BCL2
45follicular lymphoma10.0BAX, BCL2
46basal cell carcinoma10.0BCL2, BAX
47acute promyelocytic leukemia10.0BAX, BCL2
48b-cell chronic lymphocytic leukemia10.0BAX, BCL2
49gastric adenocarcinoma10.0BAX, BCL2
50colon adenocarcinoma10.0BCL2, BAX

Graphical network of the top 20 diseases related to Malignant Teratoma:



Diseases related to malignant teratoma

Symptoms for Malignant Teratoma

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Drugs & Therapeutics for Malignant Teratoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Malignant Teratoma

Drug clinical trials:

Search ClinicalTrials for Malignant Teratoma

Search NIH Clinical Center for Malignant Teratoma

Search CenterWatch for Malignant Teratoma

Genetic Tests for Malignant Teratoma

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Anatomical Context for Malignant Teratoma

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34MalaCards
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MalaCards organs/tissues related to Malignant Teratoma:

34
Testis, Thyroid, Ovary, Lung, Brain, Heart, Medulla oblongata, Myeloid, Lymph node, Colon, Spinal cord, Spleen, Pineal

Animal Models for Malignant Teratoma or affiliated genes

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Publications for Malignant Teratoma

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53PubMed
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Articles related to Malignant Teratoma:

(show top 50)    (show all 149)
idTitleAuthorsYear
1
Primary malignant teratoma of lung: report of a case and review of the literature. (22180529)
2012
2
Unusual presentation of fetus-in-fetu mimicking malignant teratoma. (21922882)
2011
3
Successful pregnancy after treatment for ovarian malignant teratoma with growing teratoma syndrome. (19152879)
2009
4
Metastatic malignant teratoma arising from mediastinal nonseminomatous germ cell tumor: a case report. (18472634)
2008
5
Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report. (17596674)
2007
6
Malignant teratoma 32 years after treatment of germ cell tumor confined to testis. (16566989)
2006
7
Malignant teratoma of the medulla oblongata in an adult male. (11810399)
2001
8
Malignant teratoma of the testis presenting with bilateral inguinal lymphadenopathy and diagnosed by fine needle aspiration (FNA). (9134338)
1997
9
Retroperitoneal surgery: its wider role in the management of malignant teratoma. (8777620)
1996
10
Retroperitoneal malignant teratoma. A case report. (8935151)
1995
11
Management of malignant teratoma: does referral to a specialist unit matter? (8096954)
1993
12
Resection of an intracardiac metastasis from malignant teratoma of the testis. (8267441)
1993
13
Malignant teratoma arising in a dysgenetic gonad. (7690731)
1993
14
Pilot study to evaluate impact of a policy of adjuvant chemotherapy for high risk stage 1 malignant teratoma on overall relapse rate of stage 1 cancer patients. (1279211)
1992
15
Malignant teratoma of the thyroid: case report and literature review of thyroid teratoma in adults. (1634206)
1992
16
HCG producing malignant teratoma of the testis: a rare cause of precocious isosexual maturation in boys]. (1706819)
1990
17
Delivery of a normal infant following cisplatin, vinblastine, and bleomycin (PVB) chemotherapy for malignant teratoma of the ovary during pregnancy. (1693127)
1990
18
Prolonged survival in a patient with disseminated malignant teratoma in the presence of a persistently elevated serum alpha-fetoprotein level. (2464429)
1989
19
Jejunocolic fistula after radiation for malignant teratoma. (2926749)
1989
20
Malignant teratoma of the left colon associated with chronic ulcerative colitis. (3107210)
1987
21
Intracardiac metastases from malignant teratoma of the testis. (3724214)
1986
22
Pericardial tube for obstruction of superior vena cava by malignant teratoma. (3951247)
1986
23
Malignant teratoma in the thyroid gland of an adult: a case report and a review of the literature. (3775664)
1986
24
Hepatocellular carcinoma masquerading as malignant teratoma. (2999389)
1985
25
Intracranial malignant teratoma. (4033875)
1985
26
Malignant teratoma of the thyroid in an adult: CT appearance. (3968263)
1985
27
Paraplegia in children with malignant teratoma. (4027941)
1985
28
Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses A clinicopathologic study of 20 cases. (6322958)
1984
29
Malignant teratoma--with emphasis on the yolk sac tumor component. (6202823)
1984
30
Serum tumour marker regression rate following chemotherapy for malignant teratoma. (6209145)
1984
31
Acute megakaryocytic leukemia following chemotherapy for a malignant teratoma. (6198998)
1984
32
Acute leukemia following a malignant teratoma in a child with Klinefelter's syndrome: case report and review of secondary leukemias in children following treatment of a primary neoplasm. (6178494)
1982
33
Testicular seminoma with contralateral malignant teratoma. (7360064)
1980
34
Malignant teratoma of the ovary: prognostic factors and treatment. (686082)
1978
35
Primary intracranial mixed choriocarcinoma and malignant teratoma. (96120)
1978
36
Intracerebral metastatic malignant teratoma in the region of the optic chiasm. (1275862)
1976
37
Malignant teratoma arising within a lipomeningocele. Case report. (1194945)
1975
38
Malignant teratoma of the spleen. (5578744)
1971
39
Malignant teratoma of the paranasal sinuses. Report of a case. (5438743)
1970
40
Intrapulmonary malignant teratoma. (5357698)
1969
41
Solid malignant teratoma of the ovary in a 79-year-old woman. (6039513)
1967
42
Malignant teratoma of the neck. (6024733)
1967
43
Solid malignant teratoma of the ovary. (13851484)
1960
44
Malignant teratoma of the ovary. (13726193)
1960
45
Malignant teratoma of the ovary, primary chorionepithelioma, and sarcoma. (13238485)
1955
46
Malignant teratoma in the thyroid gland of an adult. (13125254)
1954
47
Malignant teratoma of the testicle in an infant four months of age. (14848701)
1951
48
Malignant teratoma of anterior mediastinum, involving pericardium, pleura and right lung. (18914789)
1948
49
Roentgen therapy for malignant teratoma of the testis. (20990621)
1946
50
Malignant Teratoma of the Mediastinum: Report of a Case and Review of 24 Cases From the Literature. (19970272)
1936

Variations for Malignant Teratoma

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Expression for genes affiliated with Malignant Teratoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Teratoma

Search GEO for disease gene expression data for Malignant Teratoma.

Pathways for genes affiliated with Malignant Teratoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 58SinoBiological, 55R&D Systems, 62Tocris Bioscience, 31KEGG, 61Thomson Reuters, 54QIAGEN, 5Cell Signaling Technology, 56Reactome, 13EMD Millipore, 52PharmGKB
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Pathways related to Malignant Teratoma according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3BAX, BCL2
2
Show member pathways
9.3BAX, BCL2
3
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.3BAX, BCL2
4
Show member pathways
9.3BCL2, BAX
5
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.3BAX, BCL2
6
Show member pathways
Signal transduction PTEN pathway61
9.3BAX, BCL2
79.3BAX, BCL2
89.3BCL2, BAX
9
Show member pathways
Apoptosis and survival BAD phosphorylation61
Development Alpha 2 adrenergic receptor activation of ERK61
Chemotaxis CXCR4 signaling pathway61
9.3BAX, BCL2
109.3BAX, BCL2
11
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.3BAX, BCL2
129.3BAX, BCL2
139.3BCL2, BAX
149.3BAX, BCL2
15
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
9.3BAX, BCL2
16
Show member pathways
9.3BCL2, BAX
17
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.3BAX, BCL2
18
Show member pathways
9.3BAX, BCL2
199.3BAX, BCL2
20
Show member pathways
9.3BCL2, BAX
219.3BAX, BCL2
22
Show member pathways
9.3BAX, BCL2
239.3BAX, BCL2
249.3BAX, BCL2
25
Show member pathways
Amyotrophic lateral sclerosis (ALS)39
9.3BCL2, BAX
26
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.3BAX, BCL2
27
Show member pathways
9.3BAX, BCL2
289.3BCL2, BAX
29
Show member pathways
FAS pathway and Stress induction of HSP regulation39
Apoptosis and survival FAS signaling cascades61
Caspase cascade in apoptosis39
9.3BAX, BCL2
30
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways61
9.3BAX, BCL2
31
Show member pathways
9.3BAX, BCL2
329.3BAX, BCL2

Compounds for genes affiliated with Malignant Teratoma

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Sources:
62Tocris Bioscience, 46Novoseek, 12DrugBank, 3BitterDB, 52PharmGKB, 30IUPHAR, 25HMDB
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Compounds related to Malignant Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1bax channel blocker629.8BCL2, BAX
2mim1629.8BAX, BCL2
3bax inhibitor peptide v5629.8BAX, BCL2
4ha14-1629.8BCL2, BAX
5ponicidin469.8BAX, BCL2
6at 101629.8BAX, BCL2
7tanshinone iia469.8BCL2, BAX
8gambogic acid469.8BCL2, BAX
9evodiamine469.7BCL2, BAX
10ptpc469.7BAX, BCL2
11bongkrekic acid469.7BAX, BCL2
12oridonin469.7BAX, BCL2
13bufalin469.7BCL2, BAX
144,6-diamidino-2-phenylindole469.7BCL2, BAX
1510-hydroxycamptothecin469.7BCL2, BAX
16beta-lapachone469.7BAX, BCL2
17ursolic acid469.7BAX, BCL2
18sanguinarine469.7BCL2, BAX
19ginsenoside469.7BCL2, BAX
20exisulind469.7BCL2, BAX
21shikonin469.7BAX, BCL2
22pd 169316469.7BAX, BCL2
23diallyl disulfide469.7BAX, BCL2
24chlorambucil46 1210.6BCL2, BAX
25olomoucine46 1210.6BAX, BCL2
26phenethyl isothiocyanate3 4610.6BAX, BCL2
27hoechst 33342469.6BCL2, BAX
28vitamin e succinate469.6BCL2, BAX
29z-vad-fmk46 6210.6BAX, BCL2
30sulindac sulfide469.5BAX, BCL2
31noxa469.5BCL2, BAX
32eb 108946 6210.4BCL2, BAX
33cd 437469.4BAX, BCL2
34triptolide469.3BCL2, BAX
35indole-3-carbinol469.3BAX, BCL2
36gossypol469.3CGB5, BAX, BCL2
37c2ceramide469.3BCL2, BAX, CGB5
38vinblastine46 52 1211.3CGB5, BAX, BCL2
39vincristine46 52 1211.2CGB5, BAX, BCL2
402-chlorodeoxyadenosine469.2BCL2, BAX
41etoposide46 52 62 1212.2CGB5, BAX, BCL2
42tamoxifen46 52 30 1212.1BCL2, BAX, CGB5
43paclitaxel46 52 1211.1CGB5, BAX, BCL2
44doxorubicin46 52 1211.1CGB5, BAX, BCL2
45actinomycin d469.0BCL2, BAX, CGB5
46genistein46 30 62 3 25 1214.0CGB5, BAX, BCL2
47phosphatidylserine46 30 1210.9BCL2, BAX, CD99
48cisplatin46 52 62 1211.5CGB5, BAX, BCL2
49paraffin468.4CGB5, CD99, BAX, BCL2
50vegf468.4CGB5, CD99, BAX, BCL2

GO Terms for genes affiliated with Malignant Teratoma

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17Gene Ontology
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Cellular components related to Malignant Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:0057419.3BAX, BCL2
2pore complexGO:0469309.0BAX, BCL2

Biological processes related to Malignant Teratoma according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of nitrogen utilizationGO:0068089.7BAX, BCL2
2regulation of protein heterodimerization activityGO:0434979.7BCL2, BAX
3regulation of protein homodimerization activityGO:0434969.7BCL2, BAX
4endoplasmic reticulum calcium ion homeostasisGO:0324699.7BAX, BCL2
5response to acidGO:0011019.7BAX, BCL2
6negative regulation of apoptotic signaling pathwayGO:20012349.6BCL2, BAX
7B cell homeostasisGO:0017829.6BAX, BCL2
8cellular response to organic substanceGO:0713109.6BAX, BCL2
9regulation of mitochondrial membrane potentialGO:0518819.6BCL2, BAX
10homeostasis of number of cells within a tissueGO:0488739.6BAX, BCL2
11intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:0700599.6BAX, BCL2
12release of cytochrome c from mitochondriaGO:0018369.6BCL2, BAX
13response to gamma radiationGO:0103329.6BAX, BCL2
14positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.5BAX, BCL2
15neuron apoptotic processGO:0514029.5BCL2, BAX
16extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.5BAX, BCL2
17extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.4BCL2, BAX
18ovarian follicle developmentGO:0015419.4BAX, BCL2
19intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.3BAX, BCL2
20negative regulation of neuron apoptotic processGO:0435249.3BAX, BCL2
21intrinsic apoptotic signaling pathwayGO:0971939.2BCL2, BAX
22response to toxic substanceGO:0096369.0BAX, BCL2

Molecular functions related to Malignant Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1channel activityGO:0152679.3BAX, BCL2
2BH3 domain bindingGO:0514349.0BAX, BCL2

Products for genes affiliated with Malignant Teratoma

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  • Antibodies
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Sources for Malignant Teratoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet