MCID: MLG081
MIFTS: 48

Malignant Teratoma malady

Cancer diseases, Rare diseases categories
Download this MalaCard

Summaries for Malignant Teratoma

About this section


Fully expand this MalaCard
MalaCards based summary: Malignant Teratoma, also known as primary malignant extragonadal teratoma, is related to teratoma and leukemia. An important gene associated with Malignant Teratoma is BAX (BCL2-associated X protein), and among its related pathways are Integrated Breast Cancer Pathway and TNF Signaling. The compounds mim1 and ponicidin have been mentioned in the context of this disorder. Affiliated tissues include testis, thyroid and ovary.

Aliases & Classifications for Malignant Teratoma

About this section

Malignant Teratoma, Aliases & Descriptions:

Name: Malignant Teratoma 8
Primary Malignant Extragonadal Teratoma 8 62
Malignant Extragonadal Teratoma 8 62
 
Teratoma, Malignant 62
Immature Teratoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases


External Ids:

Disease Ontology8 DOID:5563
NCIt39 C4286
SNOMED-CT57 189847002, 19467007
MeSH34 D013724

Related Diseases for Malignant Teratoma

About this section

Diseases in the Malignant Teratoma family:

Intermediate Malignant Teratoma Adult Teratoma
Teratoma

Diseases related to Malignant Teratoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma31.8CGB5, CD99
2leukemia30.0CD99, BAX, BCL2
3adenocarcinoma29.6BAX, CGB5, BCL2
4myeloid leukemia29.6BAX, BCL2
5thyroiditis10.6
6gliomatosis peritonei10.6
7childhood immature teratoma of ovary10.4
8central nervous system immature teratoma10.4
9immature teratoma of ovary10.4
10adult central nervous system immature teratoma10.3
11childhood central nervous system immature teratoma10.3
12pineal region immature teratoma10.3
13neuronitis10.3
14precocious puberty10.3
15mixed germ cell tumor10.3
16intermediate malignant teratoma10.3
17uterine inversion10.3
18encephalitis10.3
19polyembryoma10.3
20sinusitis10.2
21mediastinitis10.2
22seminoma10.2
23lung cancer10.2BCL2
24malignant gastric teratoma10.2
25klinefelter's syndrome10.2
26cervicitis10.2
27sarcoma10.2
28germ cell tumors10.2
29wilms tumor10.1
30quadriplegia10.1
31clear cell adenocarcinoma10.1
32malignant histiocytosis10.1
33choroiditis10.1
34endodermal sinus tumor10.1
35endometrial adenocarcinoma10.1
36endometriosis10.1
37histiocytosis10.1
38malignant ependymoma10.1
39oligodendroglioma10.1
40ovarian embryonal carcinoma10.1
41ependymoma10.1
42limbic encephalitis10.1
43mayer-rokitansky-kuster-hauser syndrome10.1
44neuroepithelioma10.1
45laryngeal squamous cell carcinoma10.0BCL2, BAX
46follicular lymphoma10.0BAX, BCL2
47basal cell carcinoma10.0BAX, BCL2
48acute promyelocytic leukemia10.0BAX, BCL2
49gastric adenocarcinoma10.0BCL2, BAX
50acute leukemia10.0

Graphical network of the top 20 diseases related to Malignant Teratoma:



Diseases related to malignant teratoma

Symptoms for Malignant Teratoma

About this section

Drugs & Therapeutics for Malignant Teratoma

About this section

Drug clinical trials:

Search ClinicalTrials for Malignant Teratoma

Search NIH Clinical Center for Malignant Teratoma

Genetic Tests for Malignant Teratoma

About this section

Anatomical Context for Malignant Teratoma

About this section

MalaCards organs/tissues related to Malignant Teratoma:

32
Testis, Thyroid, Ovary, Lung, Brain, Heart, Lymph node, Spleen, Spinal cord, Colon, Liver, Myeloid, Medulla oblongata, Pineal

Animal Models for Malignant Teratoma or affiliated genes

About this section

Publications for Malignant Teratoma

About this section

Articles related to Malignant Teratoma:

(show top 50)    (show all 148)
idTitleAuthorsYear
1
Chemoresponsive liver hemangioma in a patient with metastatic malignant teratoma. (25168798)
2014
2
Primary malignant teratoma of lung: report of a case and review of the literature. (22180529)
2012
3
Unusual presentation of fetus-in-fetu mimicking malignant teratoma. (21922882)
2011
4
Successful pregnancy after treatment for ovarian malignant teratoma with growing teratoma syndrome. (19152879)
2009
5
Metastatic malignant teratoma arising from mediastinal nonseminomatous germ cell tumor: a case report. (18472634)
2008
6
Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report. (17596674)
2007
7
Malignant teratoma 32 years after treatment of germ cell tumor confined to testis. (16566989)
2006
8
Malignant teratoma of the medulla oblongata in an adult male. (11810399)
2001
9
Malignant teratoma of the testis presenting with bilateral inguinal lymphadenopathy and diagnosed by fine needle aspiration (FNA). (9134338)
1997
10
Retroperitoneal surgery: its wider role in the management of malignant teratoma. (8777620)
1996
11
Retroperitoneal malignant teratoma. A case report. (8935151)
1995
12
Management of malignant teratoma: does referral to a specialist unit matter? (8096954)
1993
13
Resection of an intracardiac metastasis from malignant teratoma of the testis. (8267441)
1993
14
Malignant teratoma arising in a dysgenetic gonad. (7690731)
1993
15
Pilot study to evaluate impact of a policy of adjuvant chemotherapy for high risk stage 1 malignant teratoma on overall relapse rate of stage 1 cancer patients. (1279211)
1992
16
Malignant teratoma of the thyroid: case report and literature review of thyroid teratoma in adults. (1634206)
1992
17
HCG producing malignant teratoma of the testis: a rare cause of precocious isosexual maturation in boys]. (1706819)
1990
18
Delivery of a normal infant following cisplatin, vinblastine, and bleomycin (PVB) chemotherapy for malignant teratoma of the ovary during pregnancy. (1693127)
1990
19
Prolonged survival in a patient with disseminated malignant teratoma in the presence of a persistently elevated serum alpha-fetoprotein level. (2464429)
1989
20
Jejunocolic fistula after radiation for malignant teratoma. (2926749)
1989
21
Malignant teratoma of the left colon associated with chronic ulcerative colitis. (3107210)
1987
22
Intracardiac metastases from malignant teratoma of the testis. (3724214)
1986
23
Pericardial tube for obstruction of superior vena cava by malignant teratoma. (3951247)
1986
24
Malignant teratoma in the thyroid gland of an adult: a case report and a review of the literature. (3775664)
1986
25
Hepatocellular carcinoma masquerading as malignant teratoma. (2999389)
1985
26
Intracranial malignant teratoma. (4033875)
1985
27
Malignant teratoma of the thyroid in an adult: CT appearance. (3968263)
1985
28
Paraplegia in children with malignant teratoma. (4027941)
1985
29
Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses A clinicopathologic study of 20 cases. (6322958)
1984
30
Malignant teratoma--with emphasis on the yolk sac tumor component. (6202823)
1984
31
Serum tumour marker regression rate following chemotherapy for malignant teratoma. (6209145)
1984
32
Acute megakaryocytic leukemia following chemotherapy for a malignant teratoma. (6198998)
1984
33
Acute leukemia following a malignant teratoma in a child with Klinefelter's syndrome: case report and review of secondary leukemias in children following treatment of a primary neoplasm. (6178494)
1982
34
Pregnancy specific beta 1 glycoprotein: a comparison of analysis by radioimmunoassay and enzyme linked immunosorbent assay observations on patients with malignant teratoma of testis. (6974761)
1981
35
Testicular seminoma with contralateral malignant teratoma. (7360064)
1980
36
Malignant teratoma of the ovary: prognostic factors and treatment. (686082)
1978
37
Primary intracranial mixed choriocarcinoma and malignant teratoma. (96120)
1978
38
Malignant teratoma arising within a lipomeningocele. Case report. (1194945)
1975
39
Malignant teratoma of the spleen. (5578744)
1971
40
Malignant teratoma of the paranasal sinuses. Report of a case. (5438743)
1970
41
Intrapulmonary malignant teratoma. (5357698)
1969
42
Solid malignant teratoma of the ovary in a 79-year-old woman. (6039513)
1967
43
Malignant teratoma of the neck. (6024733)
1967
44
Solid malignant teratoma of the ovary. (13851484)
1960
45
Malignant teratoma of the ovary. (13726193)
1960
46
Malignant teratoma of the ovary, primary chorionepithelioma, and sarcoma. (13238485)
1955
47
Malignant teratoma in the thyroid gland of an adult. (13125254)
1954
48
Malignant teratoma of the testicle in an infant four months of age. (14848701)
1951
49
Roentgen therapy for malignant teratoma of the testis. (20990621)
1946
50
Malignant Teratoma of the Mediastinum: Report of a Case and Review of 24 Cases From the Literature. (19970272)
1936

Variations for Malignant Teratoma

About this section

Expression for genes affiliated with Malignant Teratoma

About this section
Expression patterns in normal tissues for genes affiliated with Malignant Teratoma

Search GEO for disease gene expression data for Malignant Teratoma.

Pathways for genes affiliated with Malignant Teratoma

About this section

Pathways related to Malignant Teratoma according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3BAX, BCL2
2
Show member pathways
9.3BAX, BCL2
3
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.3BAX, BCL2
4
Show member pathways
9.3BCL2, BAX
5
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.3BAX, BCL2
6
Show member pathways
Signal transduction PTEN pathway60
9.3BAX, BCL2
79.3BAX, BCL2
89.3BCL2, BAX
9
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.3BAX, BCL2
109.3BAX, BCL2
11
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3BAX, BCL2
129.3BAX, BCL2
139.3BCL2, BAX
149.3BAX, BCL2
15
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.3BAX, BCL2
16
Show member pathways
9.3BCL2, BAX
17
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.3BAX, BCL2
18
Show member pathways
9.3BAX, BCL2
199.3BAX, BCL2
20
Show member pathways
9.3BCL2, BAX
219.3BAX, BCL2
22
Show member pathways
9.3BAX, BCL2
239.3BAX, BCL2
249.3BAX, BCL2
25
Show member pathways
Amyotrophic lateral sclerosis (ALS)37
9.3BCL2, BAX
26
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.3BAX, BCL2
27
Show member pathways
9.3BAX, BCL2
289.3BCL2, BAX
29
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.3BAX, BCL2
30
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.3BAX, BCL2
31
Show member pathways
9.3BAX, BCL2
329.3BAX, BCL2

Compounds for genes affiliated with Malignant Teratoma

About this section

Compounds related to Malignant Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1mim1619.8BCL2, BAX
2ponicidin449.8BAX, BCL2
3at 101619.8BAX, BCL2
4ha14-1619.8BCL2, BAX
5bax channel blocker619.8BAX, BCL2
6bax inhibitor peptide v5619.8BCL2, BAX
7tanshinone iia449.8BCL2, BAX
8gambogic acid449.8BCL2, BAX
9evodiamine449.7BAX, BCL2
10ptpc449.7BCL2, BAX
11bongkrekic acid449.7BAX, BCL2
12oridonin449.7BAX, BCL2
13bufalin449.7BCL2, BAX
1410-hydroxycamptothecin449.7BAX, BCL2
154,6-diamidino-2-phenylindole449.7BCL2, BAX
16ursolic acid449.7BAX, BCL2
17beta-lapachone449.7BCL2, BAX
18sanguinarine449.7BCL2, BAX
19ginsenoside449.7BCL2, BAX
20exisulind449.7BCL2, BAX
21pd 169316449.7BCL2, BAX
22shikonin449.7BCL2, BAX
23diallyl disulfide449.7BAX, BCL2
24chlorambucil44 1110.6BCL2, BAX
25phenethyl isothiocyanate2 4410.6BAX, BCL2
26olomoucine44 1110.6BAX, BCL2
27hoechst 33342449.6BAX, BCL2
28vitamin e succinate449.6BAX, BCL2
29z-vad-fmk44 6110.6BAX, BCL2
30sulindac sulfide449.5BCL2, BAX
31noxa449.5BCL2, BAX
32eb 108944 6110.4BCL2, BAX
33cd 437449.4BCL2, BAX
34triptolide449.3BCL2, BAX
35indole-3-carbinol449.3BAX, BCL2
36gossypol449.3BCL2, BAX, CGB5
37c2ceramide449.3CGB5, BAX, BCL2
38vinblastine44 50 1111.3BAX, CGB5, BCL2
39vincristine44 50 1111.2BAX, CGB5, BCL2
402-chlorodeoxyadenosine449.2BCL2, BAX
41etoposide44 50 61 1112.2BAX, BCL2, CGB5
42tamoxifen44 50 28 1112.1CGB5, BAX, BCL2
43paclitaxel44 50 1111.1BAX, BCL2, CGB5
44doxorubicin44 50 1111.1BCL2, BAX, CGB5
45actinomycin d449.0BAX, BCL2, CGB5
46genistein44 28 61 2 24 1114.0CGB5, BAX, BCL2
47phosphatidylserine44 28 1110.9CD99, BAX, BCL2
48cisplatin44 50 61 1111.5BCL2, CGB5, BAX
49paraffin448.4CGB5, BCL2, BAX, CD99
50vegf448.4BAX, CD99, BCL2, CGB5

GO Terms for genes affiliated with Malignant Teratoma

About this section

Cellular components related to Malignant Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:0057419.3BAX, BCL2
2pore complexGO:0469309.0BAX, BCL2

Biological processes related to Malignant Teratoma according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of nitrogen utilizationGO:0068089.7BAX, BCL2
2regulation of protein heterodimerization activityGO:0434979.7BCL2, BAX
3regulation of protein homodimerization activityGO:0434969.7BCL2, BAX
4endoplasmic reticulum calcium ion homeostasisGO:0324699.7BAX, BCL2
5response to acidGO:0011019.7BAX, BCL2
6negative regulation of apoptotic signaling pathwayGO:20012349.6BCL2, BAX
7B cell homeostasisGO:0017829.6BAX, BCL2
8cellular response to organic substanceGO:0713109.6BAX, BCL2
9regulation of mitochondrial membrane potentialGO:0518819.6BCL2, BAX
10homeostasis of number of cells within a tissueGO:0488739.6BAX, BCL2
11intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:0700599.6BAX, BCL2
12release of cytochrome c from mitochondriaGO:0018369.6BCL2, BAX
13response to gamma radiationGO:0103329.6BAX, BCL2
14positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.5BAX, BCL2
15neuron apoptotic processGO:0514029.5BCL2, BAX
16extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.5BAX, BCL2
17extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.4BCL2, BAX
18ovarian follicle developmentGO:0015419.4BAX, BCL2
19intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.3BAX, BCL2
20negative regulation of neuron apoptotic processGO:0435249.3BAX, BCL2
21intrinsic apoptotic signaling pathwayGO:0971939.2BCL2, BAX
22response to toxic substanceGO:0096369.0BAX, BCL2

Molecular functions related to Malignant Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1channel activityGO:0152679.3BAX, BCL2
2BH3 domain bindingGO:0514349.0BAX, BCL2

Products for genes affiliated with Malignant Teratoma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Malignant Teratoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet