MCID: MLG081
MIFTS: 46

Malignant Teratoma malady

Summaries for Malignant Teratoma

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Malignant Teratoma, also known as primary malignant extragonadal teratoma, is related to seminoma and sarcoma. An important gene associated with Malignant Teratoma is BAX (BCL2-associated X protein), and among its related pathways are Pathogenesis of ALS and Apoptosis and survival Apoptotic TNF-family pathways. The compounds vincristine and bax channel blocker have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and thyroid.

Aliases & Classifications for Malignant Teratoma

About this section
Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
See all sources

Aliases & Descriptions:

malignant teratoma 8
primary malignant extragonadal teratoma 8
teratoma, malignant, no icd-o subtype 8
malignant extragonadal teratoma 8
teratoma, malignant 60
immature teratoma 8


External Ids:

Disease Ontology8 DOID:5563
MeSH34 D013724
SNOMED-CT56 189847002, 19467007
NCIt39 C4286

Related Diseases for Malignant Teratoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Malignant Teratoma family:

Intermediate Malignant Teratoma Adult Teratoma
Teratoma

Diseases related to Malignant Teratoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1seminoma30.2CGB5
2sarcoma30.1CD99, CGB5
3thyroiditis10.6
4adult teratoma10.4
5central nervous system immature teratoma10.4
6pineal region immature teratoma10.3
7intermediate malignant teratoma10.3
8ovarian cystic teratoma10.3
9childhood central nervous system immature teratoma10.3
10childhood immature teratoma of ovary10.3
11adult central nervous system immature teratoma10.3
12neuronitis10.3
13uterine inversion10.2
14encephalitis10.2
15acute leukemia10.2
16leukemia10.2
17mediastinitis10.2
18klinefelter's syndrome10.1
19mediastinum teratoma10.1
20cervicitis10.1
21immature teratoma of ovary10.1
22mature teratoma10.1
23testis seminoma10.1
24ovarian endometriosis10.0
25choroiditis10.0
26quadriplegia10.0
27clear cell adenocarcinoma10.0
28ovarian squamous cell carcinoma10.0
29ovarian clear cell adenocarcinoma10.0
30malignant histiocytosis10.0
31pineal region yolk sac tumor10.0
32ovarian solid teratoma10.0
33central nervous system mature teratoma10.0
34endodermal sinus tumor10.0
35endometrial adenocarcinoma10.0
36endometriosis10.0
37histiocytosis10.0
38malignant ependymoma10.0
39mature teratoma of the ovary10.0
40oligodendroglioma10.0
41ovarian embryonal carcinoma10.0
42ovarian endodermal sinus tumor10.0
43squamous cell carcinoma10.0
44synovial sarcoma10.0CD99
45rhabdomyosarcoma10.0CD99
46germinoma10.0CGB5
47teratoma10.0CD99, CGB5
48gastrointestinal system disease10.0BAX
49colon adenocarcinoma10.0BCL2, BAX
50bladder carcinoma10.0BAX, CGB5

Graphical network of the top 20 diseases related to Malignant Teratoma:



Diseases related to malignant teratoma

Clinical Features for Malignant Teratoma

About this section

Drugs & Therapeutics for Malignant Teratoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Malignant Teratoma

Drug clinical trials:

Search ClinicalTrials for Malignant Teratoma

Search NIH Clinical Center for Malignant Teratoma

Search CenterWatch for Malignant Teratoma

Genetic Tests for Malignant Teratoma

About this section

Anatomical Context for Malignant Teratoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Malignant Teratoma:

32
Ovary, Testis, Thyroid, Lung, Pineal, Heart, Colon, Brain, Myeloid, Prostate, Testes, Uterus, Spleen, Lymph node, Spinal cord, Liver, Medulla oblongata

Animal Models for Malignant Teratoma or affiliated genes

About this section

Publications for Malignant Teratoma

About this section
Sources:
50PubMed
See all sources

Articles related to Malignant Teratoma:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
Adenocarcinoma (somatic-type malignancy) in mature teratoma of anterior mediastinum. (23798089)
2013
2
Neuroendocrine carcinoma in a mediastinal teratoma as a rare variant of somatic-type malignancy. (23979407)
2013
3
Malignant transformation of a mature cystic ovarian teratoma into thyroid carcinoma, mucinous adenocarcinoma, and strumal carcinoid: a case report and literature review. (23029627)
2012
4
Primary malignant teratoma of lung: report of a case and review of the literature. (22180529)
2012
5
Teratoma with naturally occurring malignant transformation in a child. (21881357)
2011
6
Prostate tissue within teratoma component of malignant mixed germ cell tumor. (20667927)
2010
7
Malignant gastric teratoma: report of two cases from a single center. (20686897)
2010
8
Primary malignant melanoma in cystic teratoma of ovary. (19749467)
2009
9
Sacrococcygeal immature teratoma with malignant ependymoma component. (19492320)
2009
10
Malignant transformation of mature cystic teratoma of the ovary: experience at a single institution. (18823690)
2008
11
Malignant transformation of mature cystic teratoma of the ovary including three cases occurring during follow-up period. (18288405)
2008
12
Cystic malignant teratoma with early recurrence after intraoperative spillage. (19022022)
2008
13
Ruptured ovarian cystic teratoma in pregnancy with diffuse peritoneal reaction mimicking advanced ovarian malignancy: a case report. (18549490)
2008
14
Malignant ovarian tumor composed of endometrioid adenocarcinoma, clear cell adenocarcinoma, squamous cell carcinoma, yolk sac tumor and immature teratoma with prominent neuroectodermal and rhabdomyosarcomatous differentiation: a case study. (17341430)
2007
15
Poor prognosis of intraoperative rupture of mature cystic teratoma with malignant transformation. (17175475)
2006
16
Teratoma with malignant transformation: experiences of the cooperative GPOH protocols MAKEI 83/86/89/96. (17080331)
2006
17
Transcription factor GATA-6 is expressed in malignant endoderm of pediatric yolk sac tumors and in teratomas. (16006960)
2005
18
Malignant cervical teratoma: report of a case in a newborn. (15895292)
2005
19
Chemotherapy for teratoma with malignant transformation. (14645417)
2003
20
Ovarian teratoma with malignant transformation: CT diagnosis. (12034646)
2002
21
Expression of cyclooxygenase-2 in ovarian mature cystic teratomas with malignant transformation. (11605016)
2001
22
Amelanotic malignant melanoma arising in an ovarian cystic teratoma: a case report. (11575655)
2001
23
A ruptured teratoma with malignant transformation. (10939511)
2000
24
Near-haploidy in a malignant sacrococcygeal teratoma. (9973927)
1999
25
Mediastinal mature teratoma with coexistence of angiosarcoma, granulocytic sarcoma and a hematopoietic region in the tumor: a rare case of association between hematological malignancy and mediastinal germ cell tumor. (9778115)
1998
26
Mature ovarian cystic teratoma with combined squamous cell carcinoma and malignant melanoma. (9808441)
1998
27
Ovarian mature cystic teratoma with malignant transformation. An interphase cytogenetic study. (9785136)
1998
28
True malignant histiocytosis developed during chemotherapy for mediastinal immature teratoma. (8892599)
1996
29
Ifosfamide and carboplatin combined with 41.8 degrees C whole-body hyperthermia in patients with refractory sarcoma and malignant teratoma. (7923163)
1994
30
Late occurrence of malignancy following resection of a histologically mature sacrococcygeal teratoma. Report of a case and literature review. (8323438)
1993
31
Malignant melanoma arising in ovarian cystic teratoma. (1959792)
1991
32
HCG producing malignant teratoma of the testis: a rare cause of precocious isosexual maturation in boys]. (1706819)
1990
33
Ovarian mucinous cystadenocarcinoma of low malignant potential associated with a mature cystic teratoma. (3338676)
1988
34
Malignant teratoma presenting with an adrenal mass. (3581678)
1987
35
Malignant lymphoma arising within thyroid tissue in a mature cystic teratoma. (3768840)
1986
36
Immature malignant teratoma in a newborn. A case report. (6537481)
1984
37
Blastic phase of myeloproliferative syndrome coexisting with a malignant teratoma. (6836221)
1983
38
Acute leukemia following a malignant teratoma in a child with Klinefelter's syndrome: case report and review of secondary leukemias in children following treatment of a primary neoplasm. (6178494)
1982
39
Non-seminoma germ cell tumours (malignant teratoma) of the testis. Results of treatment and an analysis of prognostic factors. (6165424)
1981
40
Treatment strategies for infants with malignant sacrococcygeal teratoma. (7277158)
1981
41
Combination chemotherapy for metastatic malignant teratoma of testis. (86898)
1979
42
Alpha-fetoprotein in intracranial malignant teratoma. (92810)
1979
43
Malignant teratoma of the thyroid gland in an adolescent female. (433587)
1979
44
Malignant gliomatosis peritonei originating from cystic ovarian teratoma. (4447001)
1974
45
Malignant teratoma of the heart. (4784870)
1973
46
Malignant teratoma of the ethmoid sinus. Report of a case. (5651269)
1968
47
Solid malignant teratoma of the ovary in a 79-year-old woman. (6039513)
1967
48
SOLID MALIGNANT TERATOMA OF OVARY WITH EMBRYONAL CARCINOMA. (14134285)
1963
49
Malignant teratoma in the thyroid gland of an adult. (13125254)
1954
50
A case of malignant teratoma. (14802648)
1950

Genetic Variations for Malignant Teratoma

About this section

Expression for genes affiliated with Malignant Teratoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Malignant Teratoma

Search GEO for disease gene expression data for Malignant Teratoma.

Pathways for genes affiliated with Malignant Teratoma

About this section
Sources:
51QIAGEN, 29KEGG, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome
See all sources

Pathways related to Malignant Teratoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5BCL2, BAX
2
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
9.5BAX, BCL2
3
Hide members
9.5BCL2, BAX
4
Apoptosis and survival Caspase cascade
Hide members
9.5BCL2, BAX
59.5BCL2, BAX
69.5BAX, BCL2
7
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
Hide members
9.5BCL2, BAX
89.5BAX, BCL2
99.5BCL2, BAX
10
Hide members
9.5BCL2, BAX
119.5BCL2, BAX

Compounds for genes affiliated with Malignant Teratoma

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 2BitterDB, 28IUPHAR, 24HMDB
See all sources

Compounds related to Malignant Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1vincristine44 49 1112.4BAX
2bax channel blocker599.9BAX, BCL2
3mim1599.9BCL2, BAX
4bax inhibitor peptide v5599.9BCL2, BAX
5ha14-1599.9BAX, BCL2
6at 101599.9BAX, BCL2
7ponicidin449.9BAX, BCL2
8gambogic acid449.9BAX, BCL2
9tanshinone iia449.9BAX, BCL2
10evodiamine449.9BCL2, BAX
11ptpc449.9BCL2, BAX
12bongkrekic acid449.9BAX, BCL2
13oridonin449.9BAX, BCL2
14bufalin449.9BAX, BCL2
154,6-diamidino-2-phenylindole449.9BAX, BCL2
1610-hydroxycamptothecin449.9BAX, BCL2
17ursolic acid449.9BCL2, BAX
18beta-lapachone449.9BCL2, BAX
19sanguinarine449.9BCL2, BAX
20ginsenoside449.9BCL2, BAX
21exisulind449.9BCL2, BAX
22shikonin449.9BCL2, BAX
23pd 169316449.8BCL2, BAX
24diallyl disulfide449.8BAX, BCL2
25chlorambucil44 1110.8BCL2, BAX
26olomoucine44 1110.8BAX, BCL2
27phenethyl isothiocyanate44 210.8BAX, BCL2
28vitamin e succinate449.8BCL2, BAX
29hoechst 33342449.8BCL2, BAX
30z-vad-fmk44 5910.8BAX, BCL2
31sulindac sulfide449.8BAX, BCL2
32noxa449.7BAX, BCL2
33eb 108944 5910.7BAX, BCL2
34cd 437449.7BCL2, BAX
35triptolide449.6BCL2, BAX
362-chlorodeoxyadenosine449.5BCL2, BAX
373-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.5BCL2, BAX
38gossypol449.4BCL2, BAX, CGB5
39c2ceramide449.4CGB5, BAX, BCL2
40vinblastine44 49 1111.4BCL2, BAX, CGB5
41etoposide44 49 59 1112.3BCL2, BAX, CGB5
42tamoxifen44 49 28 1112.2BCL2, BAX, CGB5
43phosphatidylserine44 28 1111.2BAX, CD99, BCL2
44paclitaxel44 49 1111.2BCL2, BAX, CGB5
45indole-3-carbinol449.2BCL2, BAX
46doxorubicin44 49 1111.1BCL2, BAX, CGB5
47actinomycin d449.1CGB5, BAX, BCL2
48genistein44 28 59 2 11 2413.9CGB5, BAX, BCL2
49paraffin448.8BCL2, CD99, BAX, CGB5
50vegf448.7CGB5, BAX, CD99, BCL2

GO Terms for genes affiliated with Malignant Teratoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Malignant Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pore complexGO:0469309.5BCL2, BAX

Biological processes related to Malignant Teratoma according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1regulation of nitrogen utilizationGO:0068089.8BCL2, BAX
2regulation of protein heterodimerization activityGO:0434979.8BAX, BCL2
3regulation of protein homodimerization activityGO:0434969.8BAX, BCL2
4response to acidGO:0011019.8BCL2, BAX
5regulation of mitochondrial membrane potentialGO:0518819.8BAX, BCL2
6B cell homeostasisGO:0017829.8BAX, BCL2
7cellular response to organic substanceGO:0713109.7BCL2, BAX
8intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:0700599.7BCL2, BAX
9homeostasis of number of cells within a tissueGO:0488739.7BAX, BCL2
10release of cytochrome c from mitochondriaGO:0018369.7BCL2, BAX
11positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.6BCL2, BAX
12response to gamma radiationGO:0103329.6BCL2, BAX
13neuron apoptotic processGO:0514029.6BAX, BCL2
14ovarian follicle developmentGO:0015419.5BCL2, BAX
15negative regulation of neuron apoptotic processGO:0435249.5BCL2, BAX
16intrinsic apoptotic signaling pathwayGO:0971939.4BCL2, BAX
17response to toxic substanceGO:0096369.2BCL2, BAX

Molecular functions related to Malignant Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1channel activityGO:0152679.5BCL2, BAX
2BH3 domain bindingGO:0514349.2BCL2, BAX

Products for genes affiliated with Malignant Teratoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Malignant Teratoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet