MCID: MLG081
MIFTS: 41

Malignant Teratoma malady

Cancer diseases, Rare diseases categories

Summaries for Malignant Teratoma

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MalaCards based summary: Malignant Teratoma, also known as primary malignant extragonadal teratoma, is related to teratoma and leukemia. An important gene associated with Malignant Teratoma is BAX (BCL2-associated X protein), and among its related pathways are Integrated Breast Cancer Pathway and TNF Signaling. The compounds bax channel blocker and mim1 have been mentioned in the context of this disorder. Affiliated tissues include testis, thyroid and ovary.

Aliases & Classifications for Malignant Teratoma

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Malignant Teratoma, Aliases & Descriptions:

Name: Malignant Teratoma 9
Primary Malignant Extragonadal Teratoma 9
Malignant Extragonadal Teratoma 9
 
Immature Extragonadal Teratoma 60
Teratoma, Malignant 60
Immature Teratoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases


External Ids:

Disease Ontology9 DOID:5563
MeSH33 D013724
SNOMED-CT55 189847002, 19467007
NCIt38 C4286

Related Diseases for Malignant Teratoma

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Diseases in the Teratoma family:

Intermediate Malignant Teratoma Adult Teratoma
malignant teratoma

Diseases related to Malignant Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma31.8CGB5, CD99
2leukemia30.0BCL2, BAX, CD99
3adenocarcinoma29.6CGB5, BAX, BCL2
4myeloid leukemia29.6BAX, BCL2
5thyroiditis10.6
6gliomatosis peritonei10.6
7childhood immature teratoma of ovary10.5
8central nervous system immature teratoma10.5
9adult central nervous system immature teratoma10.4
10childhood central nervous system immature teratoma10.4
11pineal region immature teratoma10.4
12intermediate malignant teratoma10.4
13neuronitis10.3
14precocious puberty10.3
15mixed germ cell tumor10.3
16uterine inversion10.3
17encephalitis10.3
18polyembryoma10.3
19sinusitis10.2
20immature teratoma of ovary10.2
21mediastinitis10.2
22seminoma10.2
23lung cancer10.2BCL2
24klinefelter's syndrome10.2
25cervicitis10.2
26sarcoma10.2
27wilms tumor10.1
28sacrococcygeal teratoma10.1
29malignant histiocytosis10.1
30choroiditis10.1
31quadriplegia10.1
32clear cell adenocarcinoma10.1
33endodermal sinus tumor10.1
34endometrial adenocarcinoma10.1
35endometriosis10.1
36histiocytosis10.1
37malignant ependymoma10.1
38oligodendroglioma10.1
39ovarian embryonal carcinoma10.1
40ependymoma10.1
41limbic encephalitis10.1
42mayer-rokitansky-kuster-hauser syndrome10.1
43ovarian germ cell tumor10.1
44laryngeal squamous cell carcinoma10.0BAX, BCL2
45follicular lymphoma10.0BAX, BCL2
46basal cell carcinoma10.0BCL2, BAX
47leukemia, acute promyelocytic10.0BAX, BCL2
48hepatocellular carcinoma10.0
49acute leukemia10.0
50hemangioma10.0

Graphical network of the top 20 diseases related to Malignant Teratoma:



Diseases related to malignant teratoma

Symptoms for Malignant Teratoma

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Drugs & Therapeutics for Malignant Teratoma

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Drug clinical trials:

Search ClinicalTrials for Malignant Teratoma

Search NIH Clinical Center for Malignant Teratoma

Genetic Tests for Malignant Teratoma

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Anatomical Context for Malignant Teratoma

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MalaCards organs/tissues related to Malignant Teratoma:

31
Testis, Thyroid, Ovary, Lung, Brain, Heart, Lymph node, Spleen, Spinal cord, Colon, Liver, Myeloid, Medulla oblongata, Pineal

Animal Models for Malignant Teratoma or affiliated genes

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Publications for Malignant Teratoma

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Articles related to Malignant Teratoma:

(show top 50)    (show all 152)
idTitleAuthorsYear
1
Chemoresponsive liver hemangioma in a patient with metastatic malignant teratoma. (25168798)
2014
2
Primary malignant teratoma of lung: report of a case and review of the literature. (22180529)
2012
3
Unusual presentation of fetus-in-fetu mimicking malignant teratoma. (21922882)
2011
4
Metastatic malignant teratoma arising from mediastinal nonseminomatous germ cell tumor: a case report. (18472634)
2008
5
Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report. (17596674)
2007
6
Malignant teratoma 32 years after treatment of germ cell tumor confined to testis. (16566989)
2006
7
Malignant teratoma of the medulla oblongata in an adult male. (11810399)
2001
8
Malignant teratoma of the testis presenting with bilateral inguinal lymphadenopathy and diagnosed by fine needle aspiration (FNA). (9134338)
1997
9
Retroperitoneal surgery: its wider role in the management of malignant teratoma. (8777620)
1996
10
Retroperitoneal malignant teratoma. A case report. (8935151)
1995
11
Management of malignant teratoma: does referral to a specialist unit matter? (8096954)
1993
12
Resection of an intracardiac metastasis from malignant teratoma of the testis. (8267441)
1993
13
Malignant teratoma arising in a dysgenetic gonad. (7690731)
1993
14
Pilot study to evaluate impact of a policy of adjuvant chemotherapy for high risk stage 1 malignant teratoma on overall relapse rate of stage 1 cancer patients. (1279211)
1992
15
Malignant teratoma of the thyroid: case report and literature review of thyroid teratoma in adults. (1634206)
1992
16
HCG producing malignant teratoma of the testis: a rare cause of precocious isosexual maturation in boys]. (1706819)
1990
17
Delivery of a normal infant following cisplatin, vinblastine, and bleomycin (PVB) chemotherapy for malignant teratoma of the ovary during pregnancy. (1693127)
1990
18
Prolonged survival in a patient with disseminated malignant teratoma in the presence of a persistently elevated serum alpha-fetoprotein level. (2464429)
1989
19
Jejunocolic fistula after radiation for malignant teratoma. (2926749)
1989
20
Malignant teratoma of the left colon associated with chronic ulcerative colitis. (3107210)
1987
21
Intracardiac metastases from malignant teratoma of the testis. (3724214)
1986
22
Pericardial tube for obstruction of superior vena cava by malignant teratoma. (3951247)
1986
23
Malignant teratoma in the thyroid gland of an adult: a case report and a review of the literature. (3775664)
1986
24
Hepatocellular carcinoma masquerading as malignant teratoma. (2999389)
1985
25
Intracranial malignant teratoma. (4033875)
1985
26
Malignant teratoma of the thyroid in an adult: CT appearance. (3968263)
1985
27
Paraplegia in children with malignant teratoma. (4027941)
1985
28
Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses A clinicopathologic study of 20 cases. (6322958)
1984
29
Malignant teratoma--with emphasis on the yolk sac tumor component. (6202823)
1984
30
Serum tumour marker regression rate following chemotherapy for malignant teratoma. (6209145)
1984
31
Acute megakaryocytic leukemia following chemotherapy for a malignant teratoma. (6198998)
1984
32
Acute leukemia following a malignant teratoma in a child with Klinefelter's syndrome: case report and review of secondary leukemias in children following treatment of a primary neoplasm. (6178494)
1982
33
Pregnancy specific beta 1 glycoprotein: a comparison of analysis by radioimmunoassay and enzyme linked immunosorbent assay observations on patients with malignant teratoma of testis. (6974761)
1981
34
Testicular seminoma with contralateral malignant teratoma. (7360064)
1980
35
Malignant teratoma of the ovary: prognostic factors and treatment. (686082)
1978
36
Primary intracranial mixed choriocarcinoma and malignant teratoma. (96120)
1978
37
Intracerebral metastatic malignant teratoma in the region of the optic chiasm. (1275862)
1976
38
Malignant teratoma arising within a lipomeningocele. Case report. (1194945)
1975
39
Malignant teratoma of the spleen. (5578744)
1971
40
Malignant teratoma of the paranasal sinuses. Report of a case. (5438743)
1970
41
Intrapulmonary malignant teratoma. (5357698)
1969
42
Solid malignant teratoma of the ovary in a 79-year-old woman. (6039513)
1967
43
Malignant teratoma of the neck. (6024733)
1967
44
Solid malignant teratoma of the ovary. (13851484)
1960
45
Malignant teratoma of the ovary. (13726193)
1960
46
Malignant teratoma of the ovary, primary chorionepithelioma, and sarcoma. (13238485)
1955
47
Malignant teratoma in the thyroid gland of an adult. (13125254)
1954
48
Malignant teratoma of the testicle in an infant four months of age. (14848701)
1951
49
Roentgen therapy for malignant teratoma of the testis. (20990621)
1946
50
Malignant Teratoma of the Mediastinum: Report of a Case and Review of 24 Cases From the Literature. (19970272)
1936

Variations for Malignant Teratoma

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Expression for genes affiliated with Malignant Teratoma

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Search GEO for disease gene expression data for Malignant Teratoma.

Pathways for genes affiliated with Malignant Teratoma

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Pathways related to Malignant Teratoma according to GeneCards Suite gene sharing:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3BAX, BCL2
2
Show member pathways
9.3BAX, BCL2
3
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.3BAX, BCL2
4
Show member pathways
9.3BCL2, BAX
5
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.3BAX, BCL2
6
Show member pathways
Signal transduction PTEN pathway58
9.3BAX, BCL2
79.3BAX, BCL2
89.3BCL2, BAX
9
Show member pathways
Apoptosis and survival BAD phosphorylation58
Development Alpha 2 adrenergic receptor activation of ERK58
Chemotaxis CXCR4 signaling pathway58
9.3BAX, BCL2
109.3BAX, BCL2
11
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.3BAX, BCL2
129.3BAX, BCL2
139.3BCL2, BAX
149.3BAX, BCL2
15
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.3BAX, BCL2
16
Show member pathways
9.3BCL2, BAX
17
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.3BAX, BCL2
18
Show member pathways
9.3BAX, BCL2
199.3BAX, BCL2
20
Show member pathways
9.3BCL2, BAX
219.3BAX, BCL2
22
Show member pathways
9.3BAX, BCL2
239.3BAX, BCL2
24
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
9.3BCL2, BAX
25
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.3BAX, BCL2
26
Show member pathways
9.3BAX, BCL2
279.3BCL2, BAX
28
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
9.3BAX, BCL2
29
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
9.3BAX, BCL2
30
Show member pathways
9.3BAX, BCL2
319.3BAX, BCL2

Compounds for genes affiliated with Malignant Teratoma

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Compounds related to Malignant Teratoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1bax channel blocker599.8BCL2, BAX
2mim1599.8BAX, BCL2
3bax inhibitor peptide v5599.8BAX, BCL2
4ha14-1599.8BCL2, BAX
5ponicidin439.8BAX, BCL2
6at 101599.8BAX, BCL2
7tanshinone iia439.8BCL2, BAX
8gambogic acid439.8BCL2, BAX
9evodiamine439.7BCL2, BAX
10ptpc439.7BAX, BCL2
11bongkrekic acid439.7BAX, BCL2
12oridonin439.7BAX, BCL2
13bufalin439.7BCL2, BAX
144,6-diamidino-2-phenylindole439.7BCL2, BAX
1510-hydroxycamptothecin439.7BCL2, BAX
16beta-lapachone439.7BAX, BCL2
17ursolic acid439.7BAX, BCL2
18sanguinarine439.7BCL2, BAX
19ginsenoside439.7BCL2, BAX
20exisulind439.7BCL2, BAX
21shikonin439.7BAX, BCL2
22pd 169316439.7BAX, BCL2
23diallyl disulfide439.7BAX, BCL2
24chlorambucil43 1210.6BCL2, BAX
25olomoucine43 1210.6BAX, BCL2
26phenethyl isothiocyanate2 4310.6BAX, BCL2
27hoechst 33342439.6BCL2, BAX
28vitamin e succinate439.6BCL2, BAX
29z-vad-fmk43 5910.6BAX, BCL2
30sulindac sulfide439.5BAX, BCL2
31noxa439.5BCL2, BAX
32eb 108943 5910.4BCL2, BAX
33cd 437439.4BAX, BCL2
34triptolide439.3BCL2, BAX
35indole-3-carbinol439.3BAX, BCL2
36gossypol439.3CGB5, BAX, BCL2
37c2ceramide439.3BCL2, BAX, CGB5
38vinblastine43 49 1211.3CGB5, BAX, BCL2
39vincristine43 49 1211.2CGB5, BAX, BCL2
402-chlorodeoxyadenosine439.2BCL2, BAX
41etoposide43 49 59 1212.2CGB5, BAX, BCL2
42tamoxifen43 49 28 1212.1BCL2, BAX, CGB5
43paclitaxel43 49 1211.1CGB5, BAX, BCL2
44doxorubicin43 49 1211.1CGB5, BAX, BCL2
45actinomycin d439.0BCL2, BAX, CGB5
46genistein43 28 59 2 24 1214.0CGB5, BAX, BCL2
47phosphatidylserine43 28 1210.9BCL2, BAX, CD99
48cisplatin43 49 59 1211.5CGB5, BAX, BCL2
49paraffin438.4CGB5, CD99, BAX, BCL2
50vegf438.4CGB5, CD99, BAX, BCL2

GO Terms for genes affiliated with Malignant Teratoma

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Cellular components related to Malignant Teratoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:00057419.3BAX, BCL2
2pore complexGO:00469309.0BAX, BCL2

Biological processes related to Malignant Teratoma according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of nitrogen utilizationGO:00068089.7BAX, BCL2
2regulation of protein heterodimerization activityGO:00434979.7BCL2, BAX
3regulation of protein homodimerization activityGO:00434969.7BCL2, BAX
4endoplasmic reticulum calcium ion homeostasisGO:00324699.7BAX, BCL2
5response to acidGO:00011019.7BAX, BCL2
6negative regulation of apoptotic signaling pathwayGO:020012349.6BCL2, BAX
7B cell homeostasisGO:00017829.6BAX, BCL2
8cellular response to organic substanceGO:00713109.6BAX, BCL2
9regulation of mitochondrial membrane potentialGO:00518819.6BCL2, BAX
10homeostasis of number of cells within a tissueGO:00488739.6BAX, BCL2
11intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:00700599.6BAX, BCL2
12release of cytochrome c from mitochondriaGO:00018369.6BCL2, BAX
13response to gamma radiationGO:00103329.6BAX, BCL2
14positive regulation of intrinsic apoptotic signaling pathwayGO:020012449.5BAX, BCL2
15neuron apoptotic processGO:00514029.5BCL2, BAX
16extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.5BAX, BCL2
17extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.4BCL2, BAX
18ovarian follicle developmentGO:00015419.4BAX, BCL2
19intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.3BAX, BCL2
20negative regulation of neuron apoptotic processGO:00435249.3BAX, BCL2
21intrinsic apoptotic signaling pathwayGO:00971939.2BCL2, BAX
22response to toxic substanceGO:00096369.0BAX, BCL2

Molecular functions related to Malignant Teratoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1channel activityGO:00152679.3BAX, BCL2
2BH3 domain bindingGO:00514349.0BAX, BCL2

Products for genes affiliated with Malignant Teratoma

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Sources for Malignant Teratoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet