MTT
MCID: MLG041
MIFTS: 36

Malignant Triton Tumor (MTT) malady

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Malignant Triton Tumor

Aliases & Descriptions for Malignant Triton Tumor:

Name: Malignant Triton Tumor 12 56 14
Malignant Peripheral Nerve Sheath Tumor with Rhabdomyosarcomatous Differenciation 56
Malignant Peripheral Nerve Sheath Tumor with Rhabdomyoblastic Differentiation 69
Malignant Peripheral Nerve Sheath Neoplasm with Rhabdomyosarcoma 12
Mpnst with Rhabdomyosarcomatous Differentiation 56
Mpnst with Rhabdomyoblastic Differentiation 12
Mpnst with Rhabdomyosarcoma 12
Malignant Triton Tumour 12
Mtt 56

Characteristics:

Orphanet epidemiological data:

56
malignant triton tumor
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6707
NCIt 47 C4335
Orphanet 56 ORPHA252212
UMLS via Orphanet 70 C0334616
UMLS 69 C0334616

Summaries for Malignant Triton Tumor

MalaCards based summary : Malignant Triton Tumor, also known as malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differenciation, is related to malignant peripheral nerve sheath tumor and neurofibrosarcoma. An important gene associated with Malignant Triton Tumor is MB (Myoglobin), and among its related pathways/superpathways is Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Doxorubicin and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and thyroid, and related phenotypes are homeostasis/metabolism and muscle

Wikipedia : 71 Malignant triton tumor (MTT) is a relatively rare, aggressive tumor made up of both malignant schwannoma... more...

Related Diseases for Malignant Triton Tumor

Diseases related to Malignant Triton Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Related Disease Score Top Affiliating Genes
1 malignant peripheral nerve sheath tumor 11.4
2 neurofibrosarcoma 11.0
3 glaucoma iridogoniodysgenesia 10.1 DES MB
4 reticulohistiocytic granuloma 10.1 DES MB
5 extracutaneous mastocytoma 10.1 DES MB
6 brain stem infarction 10.1 MB MYOD1
7 rectal neoplasm 10.1 DES MB
8 ectopic pregnancy 10.1 DES MYOD1
9 endodermal sinus tumor 10.1 MB MYOD1
10 testis sarcoma 10.1 DES MYOD1
11 neurofibromatosis 10.1
12 glomerulonephritis 10.1 MB MYOD1
13 t-cell childhood lymphoblastic lymphoma 10.1 DES MB
14 cardiac tamponade 10.1 DES MYOD1
15 extraosseous osteosarcoma 10.1 DES MYOD1
16 van regemorter pierquin vamos syndrome 10.1 DES MB
17 lung benign neoplasm 10.1 DES MYOD1
18 myoma 10.1 DES S100B
19 hyperpituitarism 10.1 DES MB
20 spleen angiosarcoma 10.1 DES S100B
21 biliary papillomatosis 10.1 DES S100B
22 foix-alajouanine syndrome 10.1 DES S100B
23 neurofibromatosis, type 1 10.1
24 cavernous sinus meningioma 10.1 DES S100B
25 vulvar squamous papilloma 10.1 DES S100B
26 mediastinum liposarcoma 10.1 DES S100B
27 dyslexia 10.1 DES S100B
28 skin glomus tumor 10.1 DES S100B
29 pulmonary immaturity 10.0 MB MYOD1
30 diarrhea, chronic, with villous atrophy 10.0 DES S100B
31 mediastinum rhabdomyosarcoma 10.0 MB MYOD1
32 phagocyte bactericidal dysfunction 10.0 MB NF1
33 subacute leukemia 10.0 MB NF1
34 acute posterior multifocal placoid pigment epitheliopathy 10.0 MB S100B
35 kidney sarcoma 10.0 MYOD1 S100B
36 palmoplantar keratosis 10.0 DES MB
37 sengers syndrome 10.0 DES S100B
38 extraosseous ewing's sarcoma 10.0 DES MB
39 leukemia 10.0
40 mixed type rhabdomyosarcoma 10.0 DES MB MYOD1
41 verruciform xanthoma of skin 10.0 DES MB MYOD1
42 trombiculiasis 10.0 NF1 S100B
43 transitional cell carcinoma 10.0 DES MB MYOD1
44 bile duct rhabdomyosarcoma 10.0 DES MB MYOD1
45 neutrophil immunodeficiency syndrome 10.0 DES S100B
46 childhood medulloblastoma 10.0 DES MB MYOD1
47 spindle cell rhabdomyosarcoma 10.0 DES MB MYOD1
48 mediastinum sarcoma 10.0 DES MB MYOD1
49 prostate rhabdomyosarcoma 10.0 DES MB MYOD1
50 advanced sleep-phase syndrome, familial, 2 10.0 DES MB MYOD1

Graphical network of the top 20 diseases related to Malignant Triton Tumor:



Diseases related to Malignant Triton Tumor

Symptoms & Phenotypes for Malignant Triton Tumor

MGI Mouse Phenotypes related to Malignant Triton Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 DES MB MYOD1 NF1 S100B
2 muscle MP:0005369 8.92 NF1 DES MB MYOD1

Drugs & Therapeutics for Malignant Triton Tumor

Drugs for Malignant Triton Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3 23214-92-8 31703
2
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
3
Etoposide Approved Phase 4 33419-42-0 36462
4
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3 50-18-0, 6055-19-2 2907
5
rituximab Approved Phase 4 174722-31-7 10201696
6
Bleomycin Approved Phase 4 11056-06-7 5360373
7
Dacarbazine Approved, Investigational Phase 4 4342-03-4 5351166
8
Epirubicin Approved Phase 4 56420-45-2 41867
9
Doxil Approved June 1999 Phase 4,Phase 2,Phase 3 31703
10 Topoisomerase Inhibitors Phase 4,Phase 2,Phase 3
11 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
12 Etoposide phosphate Phase 4
13 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3
14
Cisplatin Approved Phase 2, Phase 3,Phase 1 15663-27-1 84093 441203 2767
15
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
16
Mechlorethamine Approved Phase 2, Phase 3 51-75-2 4033
17
Paclitaxel Approved, Vet_approved Phase 2, Phase 3 33069-62-4 36314
18
Fluorouracil Approved Phase 2, Phase 3 51-21-8 3385
19 Alkylating Agents Phase 2, Phase 3
20 Isophosphamide mustard Phase 2, Phase 3
21 Antineoplastic Agents, Alkylating Phase 2, Phase 3
22
s 1 (combination) Phase 2, Phase 3
23 Albumin-Bound Paclitaxel Phase 2, Phase 3
24 Immunosuppressive Agents Phase 2, Phase 3
25 Antimetabolites Phase 2, Phase 3
26 Antimetabolites, Antineoplastic Phase 2, Phase 3
27 Antimitotic Agents Phase 2, Phase 3
28 Antineoplastic Agents, Phytogenic Phase 2, Phase 3
29
Bevacizumab Approved, Investigational Phase 2 216974-75-3
30
Peginterferon alfa-2b Approved Phase 2 99210-65-8, 215647-85-1
31 interferons Phase 2
32 Angiogenesis Inhibitors Phase 2
33 Angiogenesis Modulating Agents Phase 2
34 Immunoglobulins Phase 2
35 Anti-Infective Agents Phase 2
36 Antibodies, Monoclonal Phase 2
37 Interferon-alpha Phase 2
38 Antibodies Phase 2
39 Antiviral Agents Phase 2
40
Pemetrexed Approved, Investigational Phase 1 150399-23-8, 137281-23-3 446556 60843
41
leucovorin Approved, Nutraceutical Phase 1 58-05-9 54575, 6560146 143
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
43 Folic Acid Antagonists Phase 1
44 Nucleic Acid Synthesis Inhibitors Phase 1
45 Vitamin B Complex Phase 1
46 Folate Nutraceutical Phase 1
47 arginine Nutraceutical Phase 1
48 Vitamin B9 Nutraceutical Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Clinical Application of Polyethylene Glycol Liposome Doxorubicin (PLD) in Primary Lymphoma Recruiting NCT02526823 Phase 4
2 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
3 Combination Treatment of S-1 With Paclitaxel in Advanced Esophageal Cancer Terminated NCT01704690 Phase 2, Phase 3
4 A Phase II Study of Pegylated Interferon Alfa 2b (PEG-Intron(Trademark)) in Children With Diffuse Pontine Gliomas Completed NCT00036569 Phase 2
5 Bevacizumab and PEG-Interferon Alfa-2b in Treating Patients With Metastatic or Unresectable Carcinoid Tumors Completed NCT00055809 Phase 2
6 Ph 1 Study in Subjects With Tumors Requiring Arginine to Assess ADI-PEG 20 With Pemetrexed and Cisplatin Recruiting NCT02029690 Phase 1

Search NIH Clinical Center for Malignant Triton Tumor

Genetic Tests for Malignant Triton Tumor

Anatomical Context for Malignant Triton Tumor

MalaCards organs/tissues related to Malignant Triton Tumor:

39
Lung, Kidney, Thyroid, Small Intestine, Spinal Cord

Publications for Malignant Triton Tumor

Articles related to Malignant Triton Tumor:

(show top 50) (show all 63)
id Title Authors Year
1
A rare case of recurrent malignant triton tumor in a male with NF1: Case report and mini-review. ( 26975033 )
2016
2
A case of recurrent malignant triton tumor successfully treated with radiotherapy. ( 27146005 )
2016
3
Malignant Triton Tumor of the Kidney. New Location Not Previously Reported. ( 26159374 )
2015
4
Primary epididymis malignant triton tumor: case report and review of the literature. ( 26392076 )
2015
5
Analysis of clinical features and prognosis of malignant triton tumor: A report of two cases and literature review. ( 26788168 )
2015
6
Low-grade malignant triton tumor of the neck: a case report and review of the literature. ( 25328740 )
2014
7
Malignant Triton Tumor of the Sciatic Nerve as a Secondary Malignancy after Extended Field Radiotherapy and Chemotherapy of Hodgkin's Disease. ( 24803902 )
2014
8
Malignant triton tumor of the anterior mediastinum: A case report. ( 24527089 )
2014
9
A rare case of retroperitoneal malignant Triton tumor invading renal vein and small intestine. ( 23607247 )
2013
10
Malignant triton tumor: a rare case. ( 24426617 )
2013
11
Malignant peripheral nerve sheath tumors: prognostic impact of rhabdomyoblastic differentiation (malignant triton tumors), neurofibromatosis 1 status and location. ( 23084090 )
2013
12
Malignant triton tumor of the chest wall invading the lung. A case report and literature review. ( 24470743 )
2013
13
A case of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation: malignant triton tumor. ( 24474920 )
2013
14
Intracranial malignant triton tumor in a patient with neurofibromatosis type 1: case report and review of the literature. ( 23633163 )
2013
15
Malignant Triton Tumor of Cervical Spine: Report of One Case and Review of the Literature. ( 23597523 )
2013
16
Clinico-genetic aspects of a pediatric non-neurofibromatosis type 1 malignant triton tumor with loss of chromosome X. ( 22610852 )
2012
17
Low-grade malignant triton tumor in the lumbar spine: a rare variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. ( 21732991 )
2012
18
Treatment of malignant triton tumor in zygomatic region. ( 22627455 )
2012
19
Malignant triton tumor of the retroperitoneum: a case report and review of the literature. ( 22647059 )
2012
20
A rare case of malignant triton tumor in the cerebellopontine angle. ( 22515616 )
2012
21
Long-term survival of a patient with a neurofibromatosis Type 1 associated retroperitoneal malignant triton tumor after multi-modality treatment. ( 22011741 )
2011
22
Malignant triton tumor of cervical spine with hemorrhage. ( 21414786 )
2011
23
Intracardiac malignant Triton tumor: a first presentation. ( 20172170 )
2010
24
A Rare Malignant Triton Tumor. ( 20671860 )
2010
25
Pathology quiz case 1. Diagnosis: Sinonasal malignant Triton tumor (MTT) with intracranial extension. ( 20855691 )
2010
26
Malignant Triton tumor in the retroperitoneal space associated with neurofibromatosis type 1: a case study. ( 21139906 )
2009
27
Malignant triton tumor of the brachial plexus invading the left thoracic inlet: a rare differential diagnosis of pancoast tumor. ( 19096322 )
2009
28
Malignant triton tumor of the infratemporal fossa. ( 19625850 )
2009
29
Prognostic factors for the malignant triton tumor of the head and neck. ( 19283843 )
2009
30
A rare case of malignant triton tumor with pluridirectional differentiation. ( 19279515 )
2009
31
Hedgehog-Patched pathway aberrations in a malignant triton tumor case study. ( 18636196 )
2008
32
Malignant triton tumor in a patient with Li-Fraumeni syndrome and a novel TP53 mutation. ( 16333835 )
2007
33
Chemotherapy in metastatic malignant triton tumor: report on two cases. ( 17786333 )
2007
34
Malignant triton tumor of the pelvis in a 2-year-old boy. ( 16679944 )
2006
35
Malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation (malignant triton tumor). ( 17149968 )
2006
36
Malignant triton tumor (MTT) of the neck. ( 16185834 )
2006
37
Malignant triton tumor presenting as a rectal mass in an 11-month-old. ( 15827834 )
2005
38
Malignant triton tumor of the lumbar spine. ( 15371720 )
2004
39
Radiation-induced malignant triton tumor associated with severe spinal cord compression. Case report and review of the literature. ( 15029921 )
2004
40
Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation (malignant triton tumor) with balanced t(7;9)(q11.2;p24) and unbalanced translocation der(16)t(1;16)(q23;q13). ( 15104279 )
2004
41
Schwannoma with rhabdomyoblastic differentiation: a unique variant of malignant triton tumor. ( 12766593 )
2003
42
Low-grade malignant Triton tumor of the oral cavity: a case report. ( 12789151 )
2003
43
Cytogenetic study of malignant triton tumor: a case report. ( 12850371 )
2003
44
Malignant triton tumor of the supraclavicular region arising after radiotherapy. ( 12393052 )
2002
45
Malignant triton tumor of the right vagus. ( 12400774 )
2002
46
Malignant triton tumor of the nasal cavity. ( 11774393 )
2001
47
Malignant triton tumor in the thoracic spine. ( 10855526 )
2000
48
Malignant triton tumor of the ethmoid sinus and nasal cavity. ( 11007095 )
2000
49
A malignant triton tumor with an unbalanced translocation (1;13)(q10;q10) and an isochromosome (8)(q10) as the sole karyotypic abnormalities. ( 10731598 )
2000
50
Malignant triton tumor of the head and neck: A case report and review of the literature. ( 10487955 )
1999

Variations for Malignant Triton Tumor

Expression for Malignant Triton Tumor

Search GEO for disease gene expression data for Malignant Triton Tumor.

Pathways for Malignant Triton Tumor

Pathways related to Malignant Triton Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.61 DES MYOD1

GO Terms for Malignant Triton Tumor

Biological processes related to Malignant Triton Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 skeletal muscle tissue development GO:0007519 8.62 MYOD1 NF1

Sources for Malignant Triton Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....