MCID: MLG041
MIFTS: 36

Malignant Triton Tumor

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Malignant Triton Tumor

MalaCards integrated aliases for Malignant Triton Tumor:

Name: Malignant Triton Tumor 12 55 14
Malignant Peripheral Nerve Sheath Tumor with Rhabdomyosarcomatous Differenciation 55
Malignant Peripheral Nerve Sheath Tumor with Rhabdomyoblastic Differentiation 69
Malignant Peripheral Nerve Sheath Neoplasm with Rhabdomyosarcoma 12
Mpnst with Rhabdomyosarcomatous Differentiation 55
Mpnst with Rhabdomyoblastic Differentiation 12
Mpnst with Rhabdomyosarcoma 12
Malignant Triton Tumour 12
Mtt 55

Characteristics:

Orphanet epidemiological data:

55
malignant triton tumor
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6707
NCIt 46 C4335
Orphanet 55 ORPHA252212
UMLS via Orphanet 70 C0334616
UMLS 69 C0334616

Summaries for Malignant Triton Tumor

MalaCards based summary : Malignant Triton Tumor, also known as malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differenciation, is related to neurofibromatosis, type iv, of riccardi and hemangiopericytoma, malignant. An important gene associated with Malignant Triton Tumor is MB (Myoglobin), and among its related pathways/superpathways is Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Doxorubicin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lung, small intestine and thyroid, and related phenotypes are homeostasis/metabolism and muscle

Wikipedia : 72 Malignant triton tumor (MTT) is a relatively rare, aggressive tumor made up of both malignant schwannoma... more...

Related Diseases for Malignant Triton Tumor

Diseases related to Malignant Triton Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 neurofibromatosis, type iv, of riccardi 29.8 NF1 S100B
2 hemangiopericytoma, malignant 29.8 DES S100B
3 malignant peripheral nerve sheath tumor 29.7 NF1 S100B
4 neurofibrosarcoma 11.1
5 giant cell myocarditis 10.2 DES MB
6 myofibroma 10.2 DES MB
7 bilateral retinoblastoma 10.2 DES MB
8 pleomorphic rhabdomyosarcoma 10.2 MB MYOD1
9 adult fibrosarcoma 10.2 MB MYOD1
10 adenosarcoma 10.2 DES MB
11 infantile myofibromatosis 10.1 DES MB
12 cervical polyp 10.1 DES MYOD1
13 gallbladder sarcoma 10.1 DES MYOD1
14 uterine sarcoma 10.1 DES MB
15 horner's syndrome 10.1 DES MYOD1
16 malignant fibrous histiocytoma of bone 10.1 DES MYOD1
17 glomangioma 10.1 DES MB
18 skeletal muscle cancer 10.1 MB MYOD1
19 muscle tissue disease 10.1 MB MYOD1
20 histiocytoma 10.1 MB MYOD1
21 leukemia 10.1
22 ossifying fibromyxoid tumor 10.1 DES S100B
23 myxofibrosarcoma 10.1 DES S100B
24 syringocystadenoma papilliferum 10.1 DES S100B
25 syringoma 10.0 DES S100B
26 juvenile xanthogranuloma 10.0 DES S100B
27 acute mountain sickness 10.0 MB S100B
28 pleomorphic liposarcoma 10.0 DES S100B
29 liposarcoma 10.0 DES MB
30 cutaneous fibrous histiocytoma 10.0 DES S100B
31 spindle cell sarcoma 10.0 DES S100B
32 granular cell tumor 10.0 DES S100B
33 muscular dystrophy, duchenne type 10.0 MB MYOD1
34 cervicitis 10.0
35 thyroiditis 10.0
36 extraosseous ewing's sarcoma 10.0 MYOD1 S100B
37 chordoma 10.0 DES S100B
38 orbit embryonal rhabdomyosarcoma 10.0 MB NF1
39 orbit rhabdomyosarcoma 10.0 MB NF1
40 endometrial stromal sarcoma 10.0 DES MB
41 dermatofibrosarcoma protuberans 9.9 DES S100B
42 myositis 9.9 MB MYOD1
43 inflammatory myofibroblastic tumor 9.9 DES S100B
44 lymphoblastic leukemia 9.9
45 conventional leiomyosarcoma 9.9 MYOD1 NF1
46 tarsal tunnel syndrome 9.9
47 pituitary adenoma 9.9
48 adenoma 9.9
49 nephrogenic adenofibroma 9.9 MYOD1 NF1
50 li-fraumeni syndrome 9.8

Graphical network of the top 20 diseases related to Malignant Triton Tumor:



Diseases related to Malignant Triton Tumor

Symptoms & Phenotypes for Malignant Triton Tumor

MGI Mouse Phenotypes related to Malignant Triton Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 DES MB MYOD1 NF1 S100B
2 muscle MP:0005369 8.92 DES MB MYOD1 NF1

Drugs & Therapeutics for Malignant Triton Tumor

Drugs for Malignant Triton Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6 Isophosphamide mustard Phase 2, Phase 3 0
7 Alkylating Agents Phase 2, Phase 3
8 Topoisomerase Inhibitors Phase 2, Phase 3
9 Anti-Bacterial Agents Phase 2, Phase 3
10 Antibiotics, Antitubercular Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride

Search NIH Clinical Center for Malignant Triton Tumor

Genetic Tests for Malignant Triton Tumor

Anatomical Context for Malignant Triton Tumor

MalaCards organs/tissues related to Malignant Triton Tumor:

38
Lung, Small Intestine, Thyroid, Kidney, Spinal Cord

Publications for Malignant Triton Tumor

Articles related to Malignant Triton Tumor:

(show top 50) (show all 71)
# Title Authors Year
1
Malignant Triton tumor: a rare cause of sciatic pain and foot drop. ( 28884110 )
2017
2
Malignant Triton Tumor (Malignant Peripheral Nerve Sheath Tumor With Rhabdomyoblastic Differentiation) Occurring in a Vascularized Free Flap Reconstruction Graft. ( 28387148 )
2017
3
A Case of Retroperitoneal Malignant Triton Tumor in a Nigerian Boy. ( 29089742 )
2017
4
Malignant triton tumor of the gluteal region in a patient unaffected by neurofibromatosis: A case report. ( 29110923 )
2017
5
Malignant triton tumor of trigeminal nerve-case report. ( 29279963 )
2017
6
Malignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor. ( 28924675 )
2017
7
Malignant triton tumor of the lung, infiltrating the left atrium and left ventricle, with metastasis to the small intestine. ( 28515751 )
2017
8
A case of recurrent malignant triton tumor successfully treated with radiotherapy. ( 27146005 )
2016
9
A rare case of recurrent malignant triton tumor in a male with NF1: Case report and mini-review. ( 26975033 )
2016
10
Insidious malignant triton tumor of the chest wall with late flare-up. ( 28757738 )
2016
11
Analysis of clinical features and prognosis of malignant triton tumor: A report of two cases and literature review. ( 26788168 )
2015
12
Malignant Triton Tumor of the Kidney. New Location Not Previously Reported. ( 26159374 )
2015
13
Primary epididymis malignant triton tumor: case report and review of the literature. ( 26392076 )
2015
14
Malignant triton tumor of the anterior mediastinum: A case report. ( 24527089 )
2014
15
Low-grade malignant triton tumor of the neck: a case report and review of the literature. ( 25328740 )
2014
16
Malignant Triton Tumor of the Sciatic Nerve as a Secondary Malignancy after Extended Field Radiotherapy and Chemotherapy of Hodgkin's Disease. ( 24803902 )
2014
17
Malignant triton tumor of the chest wall invading the lung. A case report and literature review. ( 24470743 )
2013
18
A case of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation: malignant triton tumor. ( 24474920 )
2013
19
Malignant Triton Tumor of Cervical Spine: Report of One Case and Review of the Literature. ( 23597523 )
2013
20
Malignant peripheral nerve sheath tumors: prognostic impact of rhabdomyoblastic differentiation (malignant triton tumors), neurofibromatosis 1 status and location. ( 23084090 )
2013
21
Malignant triton tumor: a rare case. ( 24426617 )
2013
22
A rare case of retroperitoneal malignant Triton tumor invading renal vein and small intestine. ( 23607247 )
2013
23
Intracranial malignant triton tumor in a patient with neurofibromatosis type 1: case report and review of the literature. ( 23633163 )
2013
24
Low-grade malignant triton tumor in the lumbar spine: a rare variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. ( 21732991 )
2012
25
Treatment of malignant triton tumor in zygomatic region. ( 22627455 )
2012
26
A rare case of malignant triton tumor in the cerebellopontine angle. ( 22515616 )
2012
27
Clinico-genetic aspects of a pediatric non-neurofibromatosis type 1 malignant triton tumor with loss of chromosome X. ( 22610852 )
2012
28
Malignant triton tumor of the retroperitoneum: a case report and review of the literature. ( 22647059 )
2012
29
Long-term survival of a patient with a neurofibromatosis Type 1 associated retroperitoneal malignant triton tumor after multi-modality treatment. ( 22011741 )
2011
30
Malignant triton tumor of cervical spine with hemorrhage. ( 21414786 )
2011
31
A Rare Malignant Triton Tumor. ( 20671860 )
2010
32
Pathology quiz case 1. Diagnosis: Sinonasal malignant Triton tumor (MTT) with intracranial extension. ( 20855691 )
2010
33
Intracardiac malignant Triton tumor: a first presentation. ( 20172170 )
2010
34
Prognostic factors for the malignant triton tumor of the head and neck. ( 19283843 )
2009
35
Malignant triton tumor of the infratemporal fossa. ( 19625850 )
2009
36
Malignant triton tumor of the brachial plexus invading the left thoracic inlet: a rare differential diagnosis of pancoast tumor. ( 19096322 )
2009
37
A rare case of malignant triton tumor with pluridirectional differentiation. ( 19279515 )
2009
38
Malignant Triton tumor in the retroperitoneal space associated with neurofibromatosis type 1: a case study. ( 21139906 )
2009
39
Hedgehog-Patched pathway aberrations in a malignant triton tumor case study. ( 18636196 )
2008
40
Malignant triton tumor in a patient with Li-Fraumeni syndrome and a novel TP53 mutation. ( 16333835 )
2007
41
Chemotherapy in metastatic malignant triton tumor: report on two cases. ( 17786333 )
2007
42
Malignant triton tumor of the pelvis in a 2-year-old boy. ( 16679944 )
2006
43
Malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation (malignant triton tumor). ( 17149968 )
2006
44
Malignant triton tumor (MTT) of the neck. ( 16185834 )
2006
45
Malignant triton tumor presenting as a rectal mass in an 11-month-old. ( 15827834 )
2005
46
Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation (malignant triton tumor) with balanced t(7;9)(q11.2;p24) and unbalanced translocation der(16)t(1;16)(q23;q13). ( 15104279 )
2004
47
Malignant triton tumor of the lumbar spine. ( 15371720 )
2004
48
Radiation-induced malignant triton tumor associated with severe spinal cord compression. Case report and review of the literature. ( 15029921 )
2004
49
Cytogenetic study of malignant triton tumor: a case report. ( 12850371 )
2003
50
Low-grade malignant Triton tumor of the oral cavity: a case report. ( 12789151 )
2003

Variations for Malignant Triton Tumor

Expression for Malignant Triton Tumor

Search GEO for disease gene expression data for Malignant Triton Tumor.

Pathways for Malignant Triton Tumor

Pathways related to Malignant Triton Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.61 DES MYOD1

GO Terms for Malignant Triton Tumor

Biological processes related to Malignant Triton Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal muscle tissue development GO:0007519 8.62 MYOD1 NF1

Sources for Malignant Triton Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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