MCID: MLT022
MIFTS: 48

Malt Lymphoma malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Malt Lymphoma

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MalaCards: Malt Lymphoma, also known as mucosa-associated lymphatic tissue lymphoma, is related to gastric lymphoma and adenocarcinoma, and has symptoms including acute abdominal pain/colic, mediastinal/hilar adenopathies and repeat respiratory infections. An important gene associated with Malt Lymphoma is MALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1), and among its related pathways are Immune response NFAT in immune response and Signal transduction IP3 signaling. The compounds ciap1 and rantes have been mentioned in the context of this disorder. Affiliated tissues include b cells, thyroid and lung, and related mouse phenotypes are respiratory system and immune system.

Aliases & Classifications for Malt Lymphoma

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48Orphanet, 30LifeMap Discovery™, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
malt lymphoma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

malt lymphoma 48 30
mucosa-associated lymphatic tissue lymphoma 48
mucosa-associated lymphoid tissue lymphoma 48
extranodal marginal zone b-cell lymphoma 48
maltoma 48


External Ids:

ICD10 via Orphanet26 C88.4

Related Diseases for Malt Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Malt Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1gastric lymphoma31.7IGH, MALT1, BCL6, BCL10
2adenocarcinoma30.8BIRC2, BIRC3
3central nervous system lymphoma30.6BCL6
4hairy cell leukemia30.6CD5, CD40, CXCR3, BCL6
5leukemia30.6IRF4, ZAP70, IGH, CD5, CD40, CXCR3
6burkitt's lymphoma30.4ZAP70, FOXP1, IRF4, CARD11, IGH, IGHM
7systemic lupus erythematosus30.4IGHM, TRAF2, CD40, CXCR3, CXCR5
8macroglobulinemia30.3CD5
9cryoglobulinemia30.3CD5
10arthritis30.3CXCR3
11gallbladder lymphoma30.3BCL10, MALT1
12sjogren's syndrome30.3CXCL13, CXCR3, CD40
13plasmacytoma30.3IRF4, IGH, CD40, CXCR5, BCL6
14rheumatoid arthritis30.2ZAP70, IGHM, CD5, CD40, CXCR3, CXCR5
15multiple myeloma30.0CD40, IRF4
16influenza30.0CXCR3
17hepatitis c30.0CXCR3, TRAF2, IGHM
18myeloma30.0BCL6, BIRC3, BIRC2, CXCR5, CD40, IGHM
19hodgkin's lymphoma30.0IRF4, ZAP70, IGH, IGHM, TRAF2, CD40
20diffuse large b-cell lymphoma10.7
21marginal zone b-cell lymphoma10.6
22thyroid lymphoma10.6
23thyroiditis10.6
24gastrointestinal lymphoma10.6
25colon lymphoma10.6
26orbit lymphoma10.5
27breast lymphoma10.5
28rectum lymphoma10.5
29gastric adenocarcinoma10.5
30choroiditis10.4
31lateral ventricle meningioma10.4
32composite lymphoma10.4
33chorioretinitis10.4
34intestinal disease10.4
35lipoma10.4
36lung adenocarcinoma10.4
37lung squamous cell carcinoma10.4
38meningitis10.4
39squamous cell carcinoma10.4
40lymphoproliferative syndrome 110.4
41gastritis10.4
42bladder lymphoma10.4
43duodenitis10.4
44hepatitis10.4
45esophagus lymphoma10.3
46lung lymphoma10.3
47mantle cell lymphoma10.3
48lymphoid interstitial pneumonia10.3
49somatostatinoma10.3
50pancreatic somatostatinoma10.3

Graphical network of the top 20 diseases related to Malt Lymphoma:



Diseases related to malt lymphoma

Clinical Features for Malt Lymphoma

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48Orphanet
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Symptoms:

48 (show all 16)
  • acute abdominal pain/colic
  • mediastinal/hilar adenopathies
  • repeat respiratory infections
  • lymphadenopathy/polyadenopathies
  • thyroid anomalies
  • defect/anomaly of lacrimal system
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • lung/pulmonary infiltrates
  • hematologic/blood/lymphatic cancer
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness
  • constipation
  • hyperhidrosis/increased sweating

Drugs & Therapeutics for Malt Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Malt Lymphoma

Drug clinical trials:

Search ClinicalTrials for Malt Lymphoma

Search NIH Clinical Center for Malt Lymphoma

Search CenterWatch for Malt Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Malt Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Malt Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Malt Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Malt Lymphoma

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Anatomical Context for Malt Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Malt Lymphoma:

32
B cells, Thyroid, Lung, Bone

Animal Models for Malt Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malt Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.4BCL6, CXCR3, IGHM, CARD11
2MP:000538710.0BCL10, CARD11, TLR1, IRF4, FOXP1, ZAP70
3MP:000539710.0MALT1, TRAF2, IGHM, ZAP70, FOXP1, IRF4
4MP:000287310.0ZAP70, IGHM, CD5, CD40, CXCR3, BIRC2
5MP:00053849.9MALT1, TRAF2, IGHM, ZAP70, FOXP1, IRF4

Publications for Malt Lymphoma

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Genetic Variations for Malt Lymphoma

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Expression for genes affiliated with Malt Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malt Lymphoma

Search GEO for disease gene expression data for Malt Lymphoma.

Pathways for genes affiliated with Malt Lymphoma

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Sources:
12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 52R&D Systems, 55SinoBiological, 4Cell Signaling Technology
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Pathways related to Malt Lymphoma according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response NFAT in immune response
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10.4ZAP70, IGH, IGHM
2
Signal transduction IP3 signaling
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10.4ZAP70, IGH, IGHM
3
Hide members
10.4MALT1, ZAP70, CARD11
410.4BCL10, BIRC2, MALT1
5
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10.4TLR1, BIRC2, BIRC3
6
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10.4CARD11, IGHM, MALT1, BCL10
7
Hide members
10.4BCL10, MALT1, ZAP70, CARD11
810.4CARD11, ZAP70, MALT1, BCL10
9
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10.4BCL10, MALT1, ZAP70, CARD11
10
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10.4TRAF2, BIRC2, BIRC3
1110.4TRAF2, BIRC2, BIRC3
1210.4TRAF2, BIRC2, BIRC3
1310.4TRAF2, BIRC2, BIRC3
14
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10.4BIRC3, BIRC2, TRAF2
15
Apoptosis and survival Apoptotic TNF-family pathways
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10.4BIRC3, BIRC2, TRAF2
16
Apoptosis and survival Caspase cascade
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10.4BIRC3, BIRC2, TRAF2
17
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10.4BIRC3, BIRC2, TRAF2
1810.4CXCR3, CXCR5, CXCL13
19
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10.4MALT1, MADCAM1, CD40, BCL10
20
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10.4BCL6, IGHM, IGH, ZAP70
21
Apoptosis and survival Lymphotoxin-beta receptor signaling
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10.3BIRC2, CXCL13, TRAF2
22
Hide members
10.3TLR1, MALT1, BIRC2, BIRC3, BCL10
23
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10.3BIRC3, BIRC2, TRAF2, TLR1
24
Hide members
10.3CARD11, IRF4, ZAP70, MALT1, BCL10
25
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10.3IRF4, TRAF2, BIRC2, BIRC3
2610.3TRAF2, CD40, BIRC2, BIRC3
27
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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10.3BIRC3, BIRC2, CD40, TRAF2
28
Hide members
10.3BIRC3, BIRC2, CD40, MALT1, TLR1
2910.3CARD11, ZAP70, MALT1, BCL6, BCL10
3010.3TRAF2, MALT1, BIRC2, BIRC3, BCL10
3110.3CARD11, ZAP70, IGHM, CD5, BCL6, BCL10
3210.3CARD11, TLR1, IRF4, TRAF2, MALT1, BCL10
33
Hide members
10.3TLR1, ZAP70, TRAF2, CXCR3, CXCL13
34
Hide members
10.3CARD11, TLR1, ZAP70, TRAF2, MALT1, BCL10
35
Hide members
10.3ZAP70, TRAF2, CXCR3, CXCL13, BIRC2, BIRC3
3610.2BCL10, CARD11, ZAP70, TRAF2, MALT1, CD40
37
Hide members
10.1CARD11, TLR1, IRF4, ZAP70, IGHM, TRAF2

Compounds for genes affiliated with Malt Lymphoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Malt Lymphoma according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1ciap14410.7BIRC3, BIRC2, TRAF2
2rantes4410.7CXCR5, CXCR3, CD40
3fludarabine44 1111.7BIRC3, BIRC2, CD40, ZAP70
4cycloheximide4410.7BIRC2
5ciap24410.7BIRC3, BIRC2
6cytidine44 11 2412.7ZAP70, CD40, BCL6
7rituximab44 49 1112.7ZAP70, CD40, BIRC2, BCL6
8peg-104410.6CXCL13, CXCR5
9oligonucleotide4410.6ZAP70, IGH, DUSP5, CD40, BIRC2, BIRC3
10vitamin-e4410.6BIRC3, BIRC2, CD40
11lipid4410.6CARD11, TLR1, ZAP70, TRAF2, MALT1, CD40
12sb 20358044 5911.5TRAF2, CD40, BIRC2, BIRC3
13sp 60012544 5911.5CD40, BIRC2, BIRC3
14tyrosine4410.5ZAP70, DUSP5, TRAF2, CD5, CD40, CXCR3
15serine4410.5BCL10, BIRC3, CXCR3, DUSP5
16ly2940024410.4CD40, CXCR3, BIRC2, BIRC3
17guanylate4410.4CARD11, MALT1, BCL10
18dexamethasone44 49 28 1113.3BIRC3, BIRC2, CXCR3, CD40, ZAP70
19doxorubicin44 49 1112.2BCL6, BIRC3, BIRC2, CD40
20calcium44 49 11 2412.9ZAP70, DUSP5, CD5, CD40, CXCR3, CXCR5

GO Terms for genes affiliated with Malt Lymphoma

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16Gene Ontology
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Cellular components related to Malt Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CD40 receptor complexGO:03563110.4BIRC2, CD40, TRAF2
2T cell receptor complexGO:04210110.3BCL10, ZAP70, CARD11
3plasma membraneGO:00588610.2TLR1, ZAP70, IGHM, MALT1, MADCAM1, CD5
4CBM complexGO:03244910.1MALT1, BCL10

Biological processes related to Malt Lymphoma according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of cysteine-type endopeptidase activityGO:200011610.8BIRC2, BIRC3
2necroptosisGO:07026610.8BIRC2, BIRC3
3regulation of RIG-I signaling pathwayGO:03953510.8BIRC2, BIRC3
4positive regulation of T cell activationGO:05087010.8BCL10, MALT1, TRAF2
5regulation of T cell receptor signaling pathwayGO:05085610.8MALT1, BCL10
6regulation of nucleotide-binding oligomerization domain containing signaling pathwayGO:07042410.7BIRC2, BIRC3
7T cell receptor signaling pathwayGO:05085210.7CARD11, ZAP70, MALT1, BCL10
8regulation of toll-like receptor signaling pathwayGO:03412110.7BIRC2, BIRC3
9positive regulation of B cell proliferationGO:03089010.7BCL6, CD40, CARD11
10positive regulation of NF-kappaB transcription factor activityGO:05109210.7CARD11, TRAF2, MALT1, CD40, BCL10
11positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.7BCL10, BIRC3, BIRC2, CD40, MALT1, CARD11
12NIK/NF-kappaB cascadeGO:03806110.7BIRC3, BIRC2
13regulation of inflammatory responseGO:05072710.7BIRC2, BIRC3, BCL6
14regulation of immunoglobulin secretionGO:05102310.7TRAF2, CD40
15response to fungusGO:00962010.7MALT1, BCL10
16positive regulation of T cell cytokine productionGO:00272610.7MALT1, TRAF2
17immune responseGO:00695510.7TLR1, ZAP70, IGHM, MADCAM1, CXCR5, CXCL13
18innate immune responseGO:04508710.6CARD11, TLR1, TRAF2, MALT1, BIRC2, BIRC3
19cell surface receptor signaling pathwayGO:00716610.6BIRC3, BIRC2, CXCL13, CXCR3
20response to molecule of bacterial originGO:00223710.6MALT1, BCL10
21germinal center formationGO:00246710.6CXCL13, BCL6
22positive regulation of interleukin-2 productionGO:03274310.6MALT1, TRAF2
23regulation of innate immune responseGO:04508810.6BIRC3, BIRC2
24lymph node developmentGO:04853510.5CXCL13, CXCR5
25regulation of immune responseGO:05077610.4MADCAM1, CD40, BCL6
26adaptive immune responseGO:00225010.4BCL10, ZAP70
27positive regulation of interleukin-2 biosynthetic processGO:04508610.4IRF4, CARD11
28toll-like receptor signaling pathwayGO:00222410.3BIRC2, BIRC3, BCL10
29activation of NF-kappaB-inducing kinase activityGO:00725010.1MALT1, TRAF2

Molecular functions related to Malt Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin-protein ligase activityGO:00484210.4BIRC3, BIRC2, MALT1, TRAF2
2C-X-C chemokine receptor activityGO:01649410.3CXCR5, CXCR3
3kinase activator activityGO:01920910.1BCL10, MALT1

Products for genes affiliated with Malt Lymphoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Malt Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet