MCID: MLT022
MIFTS: 58

Malt Lymphoma malady

Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories

Summaries for Malt Lymphoma

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MalaCards: Malt Lymphoma, also known as mucosa-associated lymphatic tissue lymphoma, is related to hairy cell leukemia and b-cell lymphomas, and has symptoms including nausea/vomiting/regurgitation/merycism/hyperemesis, epigastralgia/heartburn/gastric/duodenal ulcer/gastritis and lung/pulmonary infiltrates. An important gene associated with Malt Lymphoma is MALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1), and among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and Tuberculosis. The compounds ciap1 and peg-10 have been mentioned in the context of this disorder. Affiliated tissues include b cells, thyroid and colon, and related mouse phenotypes are respiratory system and cardiovascular system.

Aliases & Classifications for Malt Lymphoma

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50Orphanet, 32LifeMap Discoveryā„¢, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

50
malt lymphoma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

malt lymphoma 50 32
mucosa-associated lymphatic tissue lymphoma 50
mucosa-associated lymphoid tissue lymphoma 50
extranodal marginal zone b-cell lymphoma 50
maltoma 50


External Ids:

ICD10 via Orphanet27 C88.4

Related Diseases for Malt Lymphoma

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18GeneCards, 19GeneDecks
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Diseases related to Malt Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1hairy cell leukemia30.8CD5, BCL6, CXCR3
2b-cell lymphomas30.6CXCR3, CXCR5, IRF4, DUSP5, IGHM, IGH
3macroglobulinemia30.5CD5
4cryoglobulinemia30.5CD5
5systemic lupus erythematosus30.5TRB, CXCR3, CXCR5, IGHM
6plasmacytoma30.4IGH, IRF4, CXCR5, BCL6
7leukemia30.3IGH, IRF4, CXCR5, CXCR3, BCL6, BCL10
8sjogren's syndrome30.3CXCR3, CXCL13, TRB
9follicular lymphoma30.3CD5, ZAP70, BIRC2, BIRC3, BCL10, BCL6
10gastric lymphoma30.2IGH, MALT1, BCL6, BCL10
11rheumatoid arthritis30.2IGHM, CXCR5, CXCR3, ZAP70, CD5, TRB
12myeloma30.0IGH, IGHM, IRF4, CXCR5, BCL6, BIRC3
13peripheral t-cell lymphoma29.9CXCR3, CXCL13, BCL6, ZAP70, CD5, TRB
14burkitt's lymphoma29.8IRF4, DUSP5, IGHM, IGH, CXCR5, CXCR3
15diffuse large b-cell lymphoma10.7
16thyroiditis10.7
17marginal zone b-cell lymphoma10.7
18adenocarcinoma10.6
19choroiditis10.5
20composite lymphoma10.5
21chorioretinitis10.5
22lipoma10.5
23lung adenocarcinoma10.5
24lung squamous cell carcinoma10.5
25meningitis10.5
26lymphoproliferative syndrome 110.5
27primary cutaneous marginal zone b-cell lymphoma10.5
28gastric adenocarcinoma10.5
29gastritis10.5
30duodenitis10.4
31hepatitis10.4
32mantle cell lymphoma10.4
33dyspepsia10.3
34polyclonal hypergammaglobulinemia10.3
35pancreatic somatostatinoma10.3
36somatostatinoma10.3
37adenoma10.3
38allergic conjunctivitis10.3
39cataract10.3
40pituitary adenoma10.3
41pneumonia10.3
42lupus erythematosus10.3
43extramedullary plasmacytoma10.2
44lymphoplasmacytic lymphoma10.2
45amyloidosis10.2
46arthritis10.2
47conjunctivitis10.2
48meningioma10.2
49pancreatitis10.2
50h. pylori infection10.2

Graphical network of the top 20 diseases related to Malt Lymphoma:



Diseases related to malt lymphoma

Symptoms for Malt Lymphoma

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50Orphanet
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Symptoms:

50 (show all 16)
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • lung/pulmonary infiltrates
  • hematologic/blood/lymphatic cancer
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness
  • constipation
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • defect/anomaly of lacrimal system
  • acute abdominal pain/colic
  • mediastinal/hilar adenopathies
  • repeat respiratory infections
  • lymphadenopathy/polyadenopathies
  • thyroid anomalies
  • hyperhidrosis/increased sweating

Drugs & Therapeutics for Malt Lymphoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢
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Approved drugs:

Search CenterWatch for Malt Lymphoma

Drug clinical trials:

Search ClinicalTrials for Malt Lymphoma

Search NIH Clinical Center for Malt Lymphoma

Search CenterWatch for Malt Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Malt Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Malt Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Malt Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Malt Lymphoma

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Anatomical Context for Malt Lymphoma

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34MalaCards
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MalaCards organs/tissues related to Malt Lymphoma:

34
B cells, Thyroid, Colon, Breast, Lung, Salivary gland, Bone, T cells, Small intestine, Bone marrow, Thymus, Liver, Endothelial, Tongue, Prostate, Kidney, Nk cells, Trachea, Retina, Appendix, Lymph node

Animal Models for Malt Lymphoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Malt Lymphoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053887.9IGHM, CXCR3, FOXP1, BCL6, ZAP70, TRB
2MP:00053857.5CXCR3, FOXP1, BCL6, BIRC3, BIRC2, TRB
3MP:00028737.1IGHM, CXCR3, BCL6, BIRC3, BIRC2, ZAP70
4MP:00053846.7IGHM, CXCR5, CXCR3, CXCL13, FOXP1, BCL6
5MP:00053974.6IGHM, CD5, ZAP70, BIRC2, BIRC3, BCL10
6MP:00053874.6IGHM, TRB, CD5, ZAP70, BIRC2, BIRC3

Publications for Malt Lymphoma

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53PubMed
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Articles related to Malt Lymphoma:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
Cutaneous MALT-lymphoma: from cutaneous immunocytoma and pseudolymphoma to the current (and future) conceptions. (23529303)
2013
2
Malt Lymphoma of the Colon: a Rare Occurrence. (23912606)
2013
3
Two Cases of Diffuse Large B-Cell Lymphomas in the Cervical Lymph Nodes in Patients with Low-Grade Gastric Marginal Zone B-Cell Lymphoma (MALT Lymphoma). (23767042)
2013
4
Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon. (23423787)
2013
5
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the ileum in a 35-year-old Japanese woman. (23638229)
2013
6
A tailored health surveillance program unveils a case of MALT lymphoma in an HCV-positive health-care worker. (23420489)
2013
7
Education and imaging. Gastrointestinal: MALT lymphoma of the small bowel accompanied by NSAID-induced enteropathy. (22621456)
2012
8
CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 cases. (22406370)
2012
9
Gastric MALT lymphoma treated with primary radiotherapy in the setting of autoimmune disease. (22773797)
2012
10
Multigene methylation analysis of ocular adnexal MALT lymphoma and their relationship to Chlamydophila psittaci infection and clinical characteristics in South Korea. (22410569)
2012
11
Rectal MALT lymphoma associated with ulcerative colitis. (23600057)
2012
12
Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma. (21527528)
2011
13
From MALT lymphoma to the CBM signalosome: three decades of discovery. (21750409)
2011
14
A case of relapsed disseminated cutaneous MALT lymphoma. (22458093)
2011
15
Bilateral conjunctival MALT lymphoma mimicking chronic conjunctivitis. (20523096)
2010
16
Induction of high endothelial venule-like vessels expressing GlcNAc6ST-1-mediated L-selectin ligand carbohydrate and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in a mouse model of "Candidatus Helicobacter heilmannii"-induced gastritis and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. (21073611)
2010
17
Differential expression of NF-kappaB target genes in MALT lymphoma with and without chromosome translocation: insights into molecular mechanism. (20520640)
2010
18
From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma. (20537153)
2010
19
E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response. (20802470)
2010
20
MALT lymphoma of the rectum, presenting with rectal prolapsus: a case report. (20180989)
2010
21
Most patients with minimal histological residuals of gastric MALT lymphoma after successful eradication of Helicobacter pylori can be managed safely by a watch and wait strategy: experience from a large international series. (17639089)
2007
22
MALT lymphoma involving the kidney: a report of 10 cases and review of the literature. (17709321)
2007
23
MALT lymphoma in children: a report from the NHL-BFM Study Group. (16123999)
2006
24
Activity of rituximab plus cyclophosphamide, doxorubicin/mitoxantrone, vincristine and prednisone in patients with relapsed MALT lymphoma. (17220639)
2006
25
Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma. (17052360)
2006
26
Histopathological assessment and immunohistochemical study of nasopharyngeal low grade MALT lymphoma. (17496934)
2006
27
Rapid development of diffuse large B-Cell lymphoma after successful eradication of Helicobacter pylori for gastric MALT lymphoma. (17026570)
2006
28
MALT lymphoma associated genetic aberrations occur at different frequencies in primary and secondary intestinal MALT lymphomas. (16556668)
2006
29
Laparoscopy-assisted total gastrectomy for a case of MALT lymphoma: a case report. (16995481)
2006
30
Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity. (15894263)
2005
31
Expression of CD86 and increased infiltration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma. (16038034)
2005
32
Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma. (15711920)
2005
33
Mikulicz's disease and Mikulicz's syndrome: analysis of the original case report of 1892 in the light of current knowledge identifies a MALT lymphoma. (16122662)
2005
34
Rituximab-induced remission of a gastric MALT lymphoma. (15360017)
2004
35
Immunogenetic analysis of gastric MALT lymphoma-like lesions induced by Helicobacter pylori infection in neonatally thymectomized mice. (14968120)
2004
36
Helicobacter-independent, chemotherapy-resistant, radiosensitive gastric MALT lymphoma with massive deposits of amyloidlike substance. (14627350)
2003
37
T(11;18)(q21;q21) in gastric MALT lymphoma and diffuse large B-cell lymphoma of Chinese patients. (14502259)
2003
38
Outcome in relation to treatment modalities in 48 patients with localized gastric MALT lymphoma: a retrospective study of patients treated during 1976-2001. (12688342)
2003
39
Proposal for a new histological grading system for post-treatment evaluation of gastric MALT lymphoma. (14570741)
2003
40
Detection of HHV-8 sequences and antigens in a MALT lymphoma associated with SjAPgren's syndrome. (12653865)
2003
41
Gastric irradiation for low-grade MALT lymphoma of the stomach: report of two cases and review of the literature. (12512968)
2002
42
Primary radiotherapy for localized orbital MALT lymphoma. (11849787)
2002
43
Compartment analysis of T cell receptor gamma--and immunoglobulin V(H) rearrangements by microdissection in patients with malt lymphoma and chronic gastritis with lymphatic hyperplasia. (12030429)
2002
44
EUS in MALT lymphoma. (12297744)
2002
45
Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF-kappa B signaling pathway. (11262391)
2001
46
Breast MALT lymphoma: potential relationship between hormonal environment and female sex hormone receptor expression in lymphoma cells. (11697637)
2001
47
c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma. (11182042)
2001
48
Expression of cdc2 and cyclin B1 in Helicobacter pylori-associated gastric MALT and MALT lymphoma : relationship to cell death, proliferation, and transformation. (10623670)
2000
49
Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. (10626814)
1999
50
B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. (7726362)
1995

Variations for Malt Lymphoma

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Expression for genes affiliated with Malt Lymphoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malt Lymphoma

Search GEO for disease gene expression data for Malt Lymphoma.

Pathways for genes affiliated with Malt Lymphoma

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Sources:
51PathCards, 56Reactome, 31KEGG, 54QIAGEN, 39NCBI BioSystems Database, 5Cell Signaling Technology, 61Thomson Reuters, 55R&D Systems, 58SinoBiological
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Pathways related to Malt Lymphoma according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8MALT1, IGHM, BCL10
29.7MALT1, BCL10, TLR1
3
Show member pathways
9.7BCL10, MALT1, ZAP70
4
Show member pathways
TCR signaling in naive CD8+ T cells39
9.7BCL10, MALT1, ZAP70
5
Show member pathways
9.7MALT1, ZAP70, BCL10
69.6CXCL13, CXCR3
79.4MALT1, IRF4, TLR1, BCL10
89.4BIRC2, BIRC3
9
Show member pathways
9.4MALT1, BCL10, ZAP70, TLR1
10
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.4BCL6, IGH, IGHM
119.2BCL10, BIRC2, MALT1
12
Show member pathways
9.2CXCR5, CXCR3, CXCL13
13
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.2IRF4, BIRC2, BIRC3
14
Show member pathways
9.1BIRC3, TLR1, BIRC2
15
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.1TRB, IGH, ZAP70, IGHM
169.1BCL6, MALT1, ZAP70, BCL10
179.0BIRC3, MALT1, BCL10, BIRC2
18
Show member pathways
9.0TLR1, ZAP70, CXCL13, CXCR3
19
Show member pathways
8.9TLR1, MALT1, BIRC3, BIRC2
20
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.9TRB, MALT1, BCL10, ZAP70, IRF4
218.7CD5, ZAP70, BCL10, BCL6, IGHM
22
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.7BIRC2, TLR1, MALT1, BCL10, BIRC3
23
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
8.7BCL10, MALT1, BIRC2, TRB
24
Show member pathways
Immune response T cell receptor signaling pathway61
Immune response CD28 signaling61
Immune response ICOS pathway in T helper cell61
8.7IGHM, IGH, MALT1, BCL10, TRB, ZAP70
258.7ZAP70, MALT1, BCL10, BIRC3, BIRC2
26
Show member pathways
8.3CXCL13, ZAP70, CXCR3, BIRC2, BIRC3
27
Show member pathways
8.0BIRC3, ZAP70, BIRC2, BCL10, IGHM, MADCAM1

Compounds for genes affiliated with Malt Lymphoma

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46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 25HMDB
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Compounds related to Malt Lymphoma according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1ciap1469.6BIRC2, BIRC3
2peg-10469.6CXCL13, CXCR5
3enterotoxin469.6TRB, ZAP70
4ciap2469.6BIRC2, BIRC3
5flagellin46 3010.6CXCR3, TLR1
6fludarabine46 52 1211.3BIRC3, BIRC2, ZAP70
7paraffin468.9MALT1, BCL6, CD5, TRB
8rituximab46 52 1210.9BCL6, BIRC2, ZAP70
9cyclophosphamide46 52 1210.9BCL6, ZAP70, TRB
10serine468.3DUSP5, CXCR3, BCL6, BCL10, BIRC3, ZAP70
11oligonucleotide468.2TRB, IGH, DUSP5, BIRC3, BIRC2, ZAP70
12tyrosine468.0DUSP5, CXCR3, BCL6, BIRC3, ZAP70, CD5
13calcium46 52 25 1210.7DUSP5, CXCR5, CXCR3, CXCL13, BIRC3, ZAP70

GO Terms for genes affiliated with Malt Lymphoma

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17Gene Ontology
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Cellular components related to Malt Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CBM complexGO:03244910.0MALT1, BCL10
2immunological synapseGO:0017729.9ZAP70, BCL10
3T cell receptor complexGO:0421019.6ZAP70, BCL10
4membrane raftGO:0451218.9ZAP70, BIRC2, BIRC3, BCL10
5plasma membraneGO:0058867.6IGHM, TLR1, CXCR5, CXCR3, MADCAM1, MALT1

Biological processes related to Malt Lymphoma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell receptor signaling pathwayGO:05085610.3MALT1, BCL10
2response to fungusGO:00962010.3BCL10, MALT1
3response to molecule of bacterial originGO:00223710.2MALT1, BCL10
4positive regulation of protein ubiquitinationGO:03139810.1BIRC3, BCL10, MALT1
5positive regulation of T cell activationGO:05087010.0MALT1, BCL10
6adaptive immune responseGO:00225010.0IGHM, BCL10, ZAP70
7T cell receptor signaling pathwayGO:0508529.8ZAP70, BCL10, MALT1
8regulation of cysteine-type endopeptidase activityGO:20001169.8BIRC3, BIRC2
9regulation of RIG-I signaling pathwayGO:0395359.8BIRC3, BIRC2
10regulation of nucleotide-binding oligomerization domain containing signaling pathwayGO:0704249.8BIRC3, BIRC2
11regulation of necroptotic processGO:0605449.7BIRC3, BIRC2
12regulation of toll-like receptor signaling pathwayGO:0341219.7BIRC3, BIRC2
13NIK/NF-kappaB signalingGO:0380619.7BIRC2, BIRC3
14B cell activationGO:0421139.7ZAP70, CXCR5
15necroptotic processGO:0702669.6BIRC3, BIRC2
16germinal center formationGO:0024679.5BCL6, CXCL13
17regulation of innate immune responseGO:0450889.5BIRC2, BIRC3
18lymph node developmentGO:0485359.4CXCR5, CXCL13
19positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.3BIRC2, BIRC3, BCL10, MALT1
20toll-like receptor signaling pathwayGO:0022249.3BIRC2, BIRC3, BCL10, TLR1
21regulation of inflammatory responseGO:0507279.1BCL6, BIRC3, BIRC2
22regulation of apoptotic processGO:0429818.9BIRC2, BIRC3, MALT1
23cell surface receptor signaling pathwayGO:0071668.9BIRC2, BIRC3, CXCL13, CXCR3
24immune responseGO:0069558.8TLR1, CXCR5, CXCL13, MADCAM1, ZAP70
25innate immune responseGO:0450878.8IGHM, TLR1, MALT1, BCL10, BIRC3, BIRC2

Molecular functions related to Malt Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activator activityGO:01920910.1BCL10, MALT1
2protein self-associationGO:0436219.7MALT1, BCL10
3C-X-C chemokine receptor activityGO:0164949.7CXCR3, CXCR5
4receptor activityGO:0048729.6CD5, CXCR3, TLR1
5protein bindingGO:0055156.5DUSP5, IRF4, CXCR5, MALT1, BCL6, BCL10

Products for genes affiliated with Malt Lymphoma

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  • Antibodies
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  • Antibodies

Sources for Malt Lymphoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet