MCID: MLT022
MIFTS: 63

Malt Lymphoma malady

Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories
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Summaries for Malt Lymphoma

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Disease Ontology:8 A non-hodgkin lymphoma that has material basis in mucosal tissue involved in antibody production.

MalaCards based summary: Malt Lymphoma, also known as mucosa-associated lymphoid tissue lymphoma, is related to macroglobulinemia and central nervous system lymphoma, and has symptoms including hyperhidrosis/increased sweating, nausea/vomiting/regurgitation/merycism/hyperemesis and epigastralgia/heartburn/gastric/duodenal ulcer/gastritis. An important gene associated with Malt Lymphoma is MALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1), and among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and Tuberculosis. The compounds ciap1 and peg-10 have been mentioned in the context of this disorder. Affiliated tissues include b cells, thyroid and colon, and related mouse phenotypes are respiratory system and cardiovascular system.

Aliases & Classifications for Malt Lymphoma

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 44Novoseek, 48Orphanet, 62UMLS, 26ICD10 via Orphanet
See all sources

Malt Lymphoma, Aliases & Descriptions:

Name: Malt Lymphoma 30 8 44 48 62
Mucosa-Associated Lymphoid Tissue Lymphoma 8 48 62
Extranodal Marginal Zone B-Cell Lymphoma 48 62
 
Maltoma 48 62
Mucosa-Associated Lymphatic Tissue Lymphoma 48
Mucosa Associated Lymphatic Tissue Lymphoma 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
malt lymphoma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Normal


External Ids:

Disease Ontology8 DOID:0050909
ICD10 via Orphanet26 C88.4

Related Diseases for Malt Lymphoma

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Diseases related to Malt Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1macroglobulinemia31.3CD5
2central nervous system lymphoma31.1BCL6
3cryoglobulinemia31.1CD5
4hairy cell leukemia31.0CD5, BCL6, CXCR3
5systemic lupus erythematosus30.5TRB, CXCR3, CXCR5, IGHM
6plasmacytoma30.5IGH, IRF4, CXCR5, BCL6
7gastric lymphoma30.5IGH, MALT1, BCL6, BCL10
8sjogren's syndrome30.3CXCR3, CXCL13, TRB
9rheumatoid arthritis29.7IGHM, CXCR5, CXCR3, ZAP70, CD5, TRB
10myeloma29.5IGH, IGHM, IRF4, CXCR5, BCL6, BIRC3
11follicular lymphoma29.3CD5, ZAP70, BIRC2, BIRC3, BCL10, BCL6
12peripheral t-cell lymphoma29.2CXCR3, CXCL13, BCL6, ZAP70, CD5, TRB
13leukemia29.1IGH, IRF4, CXCR5, CXCR3, BCL6, BCL10
14b-cell lymphomas28.5CXCR3, CXCR5, IRF4, DUSP5, IGHM, IGH
15burkitt's lymphoma27.5IRF4, DUSP5, IGHM, IGH, CXCR5, CXCR3
16diffuse large b-cell lymphoma10.7
17thyroiditis10.7
18marginal zone b-cell lymphoma10.7
19adenocarcinoma10.6
20lung adenocarcinoma10.5
21composite lymphoma10.5
22choroiditis10.5
23chorioretinitis10.5
24lipoma10.5
25lung squamous cell carcinoma10.5
26meningitis10.5
27gastric adenocarcinoma10.5
28gastritis10.5
29gastric cancer10.4
30hepatitis10.4
31duodenitis10.4
32gallbladder lymphoma10.4MALT1, BCL10
33intraocular lymphoma10.4CXCR5
34edwards syndrome10.4BCL10, MALT1
35cryoglobulinemic vasculitis10.4IGHM, CD5
36cataract10.3
37pancreatic somatostatinoma10.3
38somatostatinoma10.3
39dyspepsia10.3
40polyclonal hypergammaglobulinemia10.3
41adenoma10.3
42allergic conjunctivitis10.3
43pituitary adenoma10.3
44pneumonia10.3
45plasmablastic lymphoma10.3
46mantle cell lymphoma10.3
47lupus erythematosus10.3
48lymphosarcoma10.3BCL6, IGH
49arthritis10.2
50ulcerative colitis10.2

Graphical network of the top 20 diseases related to Malt Lymphoma:



Diseases related to malt lymphoma

Symptoms for Malt Lymphoma

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Symptoms:

48 (show all 16)
  • hyperhidrosis/increased sweating
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • lung/pulmonary infiltrates
  • hematologic/blood/lymphatic cancer
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness
  • constipation
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • defect/anomaly of lacrimal system
  • acute abdominal pain/colic
  • mediastinal/hilar adenopathies
  • repeat respiratory infections
  • lymphadenopathy/polyadenopathies
  • thyroid anomalies

HPO human phenotypes related to Malt Lymphoma:

(show all 14)
id Description Frequency HPO Source Accession
1 hyperhidrosis hallmark (90%) HP:0000975
2 weight loss hallmark (90%) HP:0001824
3 nausea and vomiting hallmark (90%) HP:0002017
4 pulmonary infiltrates hallmark (90%) HP:0002113
5 abnormality of the gastric mucosa hallmark (90%) HP:0004295
6 abnormality of temperature regulation hallmark (90%) HP:0004370
7 hematological neoplasm hallmark (90%) HP:0004377
8 constipation typical (50%) HP:0002019
9 lacrimation abnormality occasional (7.5%) HP:0000632
10 abnormality of the thyroid gland occasional (7.5%) HP:0000820
11 abdominal pain occasional (7.5%) HP:0002027
12 recurrent respiratory infections occasional (7.5%) HP:0002205
13 inflammatory abnormality of the eye occasional (7.5%) HP:0100533
14 mediastinal lymphadenopathy occasional (7.5%) HP:0100721

Drugs & Therapeutics for Malt Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Malt Lymphoma

Search NIH Clinical Center for Malt Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Malt Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Malt Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Malt Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Malt Lymphoma

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Anatomical Context for Malt Lymphoma

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MalaCards organs/tissues related to Malt Lymphoma:

32
B cells, Thyroid, Colon, Breast, Lung, Salivary gland, Bone, T cells, Bone marrow, Thymus, Small intestine, Tongue, Liver, Endothelial, Lymph node, Retina, Kidney, Prostate, Nk cells, Trachea, Appendix

Animal Models for Malt Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Malt Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053887.9TRB, IGHM, CXCR3, FOXP1, BCL6, ZAP70
2MP:00053857.5BCL6, IGHM, FOXP1, TRB, BIRC2, BIRC3
3MP:00028737.1IGHM, ZAP70, TRB, CD5, BIRC2, BIRC3
4MP:00053846.7CXCR5, CXCR3, CXCL13, FOXP1, BCL6, BCL10
5MP:00053974.6IGHM, TRB, TLR1, IRF4, CXCR5, CXCR3
6MP:00053874.6TLR1, IRF4, CXCR5, CXCR3, CXCL13, FOXP1

Publications for Malt Lymphoma

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Articles related to Malt Lymphoma:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
A rare type of cancer in children: extranodal marginal zone B-cell (MALT) lymphoma of the ocular adnexa. (25341603)
2014
2
Cutaneous MALT-lymphoma: from cutaneous immunocytoma and pseudolymphoma to the current (and future) conceptions. (23529303)
2013
3
Malt Lymphoma of the Colon: a Rare Occurrence. (23912606)
2013
4
Two Cases of Diffuse Large B-Cell Lymphomas in the Cervical Lymph Nodes in Patients with Low-Grade Gastric Marginal Zone B-Cell Lymphoma (MALT Lymphoma). (23767042)
2013
5
Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon. (23423787)
2013
6
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the ileum in a 35-year-old Japanese woman. (23638229)
2013
7
A tailored health surveillance program unveils a case of MALT lymphoma in an HCV-positive health-care worker. (23420489)
2013
8
Education and imaging. Gastrointestinal: MALT lymphoma of the small bowel accompanied by NSAID-induced enteropathy. (22621456)
2012
9
CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 cases. (22406370)
2012
10
Gastric MALT lymphoma treated with primary radiotherapy in the setting of autoimmune disease. (22773797)
2012
11
Multigene methylation analysis of ocular adnexal MALT lymphoma and their relationship to Chlamydophila psittaci infection and clinical characteristics in South Korea. (22410569)
2012
12
Rectal MALT lymphoma associated with ulcerative colitis. (23600057)
2012
13
Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma. (21527528)
2011
14
From MALT lymphoma to the CBM signalosome: three decades of discovery. (21750409)
2011
15
A case of relapsed disseminated cutaneous MALT lymphoma. (22458093)
2011
16
Bilateral conjunctival MALT lymphoma mimicking chronic conjunctivitis. (20523096)
2010
17
Induction of high endothelial venule-like vessels expressing GlcNAc6ST-1-mediated L-selectin ligand carbohydrate and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in a mouse model of "Candidatus Helicobacter heilmannii"-induced gastritis and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. (21073611)
2010
18
Differential expression of NF-kappaB target genes in MALT lymphoma with and without chromosome translocation: insights into molecular mechanism. (20520640)
2010
19
From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma. (20537153)
2010
20
E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response. (20802470)
2010
21
MALT lymphoma of the rectum, presenting with rectal prolapsus: a case report. (20180989)
2010
22
Most patients with minimal histological residuals of gastric MALT lymphoma after successful eradication of Helicobacter pylori can be managed safely by a watch and wait strategy: experience from a large international series. (17639089)
2007
23
MALT lymphoma involving the kidney: a report of 10 cases and review of the literature. (17709321)
2007
24
MALT lymphoma in children: a report from the NHL-BFM Study Group. (16123999)
2006
25
Activity of rituximab plus cyclophosphamide, doxorubicin/mitoxantrone, vincristine and prednisone in patients with relapsed MALT lymphoma. (17220639)
2006
26
Histopathological assessment and immunohistochemical study of nasopharyngeal low grade MALT lymphoma. (17496934)
2006
27
Rapid development of diffuse large B-Cell lymphoma after successful eradication of Helicobacter pylori for gastric MALT lymphoma. (17026570)
2006
28
MALT lymphoma associated genetic aberrations occur at different frequencies in primary and secondary intestinal MALT lymphomas. (16556668)
2006
29
Laparoscopy-assisted total gastrectomy for a case of MALT lymphoma: a case report. (16995481)
2006
30
Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity. (15894263)
2005
31
Expression of CD86 and increased infiltration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma. (16038034)
2005
32
Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma. (15711920)
2005
33
Mikulicz's disease and Mikulicz's syndrome: analysis of the original case report of 1892 in the light of current knowledge identifies a MALT lymphoma. (16122662)
2005
34
Rituximab-induced remission of a gastric MALT lymphoma. (15360017)
2004
35
Immunogenetic analysis of gastric MALT lymphoma-like lesions induced by Helicobacter pylori infection in neonatally thymectomized mice. (14968120)
2004
36
Helicobacter-independent, chemotherapy-resistant, radiosensitive gastric MALT lymphoma with massive deposits of amyloidlike substance. (14627350)
2003
37
T(11;18)(q21;q21) in gastric MALT lymphoma and diffuse large B-cell lymphoma of Chinese patients. (14502259)
2003
38
Outcome in relation to treatment modalities in 48 patients with localized gastric MALT lymphoma: a retrospective study of patients treated during 1976-2001. (12688342)
2003
39
Proposal for a new histological grading system for post-treatment evaluation of gastric MALT lymphoma. (14570741)
2003
40
Detection of HHV-8 sequences and antigens in a MALT lymphoma associated with SjAPgren's syndrome. (12653865)
2003
41
Gastric irradiation for low-grade MALT lymphoma of the stomach: report of two cases and review of the literature. (12512968)
2002
42
Primary radiotherapy for localized orbital MALT lymphoma. (11849787)
2002
43
Compartment analysis of T cell receptor gamma--and immunoglobulin V(H) rearrangements by microdissection in patients with malt lymphoma and chronic gastritis with lymphatic hyperplasia. (12030429)
2002
44
EUS in MALT lymphoma. (12297744)
2002
45
Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF-kappa B signaling pathway. (11262391)
2001
46
Breast MALT lymphoma: potential relationship between hormonal environment and female sex hormone receptor expression in lymphoma cells. (11697637)
2001
47
c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma. (11182042)
2001
48
Expression of cdc2 and cyclin B1 in Helicobacter pylori-associated gastric MALT and MALT lymphoma : relationship to cell death, proliferation, and transformation. (10623670)
2000
49
Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. (10626814)
1999
50
B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. (7726362)
1995

Variations for Malt Lymphoma

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Expression for genes affiliated with Malt Lymphoma

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Expression patterns in normal tissues for genes affiliated with Malt Lymphoma

Search GEO for disease gene expression data for Malt Lymphoma.

Pathways for genes affiliated with Malt Lymphoma

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Pathways related to Malt Lymphoma according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8MALT1, IGHM, BCL10
29.7MALT1, BCL10, TLR1
3
Show member pathways
9.7BCL10, MALT1, ZAP70
4
Show member pathways
TCR signaling in naive CD8+ T cells37
9.7BCL10, MALT1, ZAP70
5
Show member pathways
9.7MALT1, ZAP70, BCL10
69.6CXCL13, CXCR3
79.4MALT1, IRF4, TLR1, BCL10
89.4BIRC2, BIRC3
9
Show member pathways
9.4MALT1, BCL10, ZAP70, TLR1
10
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.4BCL6, IGH, IGHM
119.2BCL10, BIRC2, MALT1
12
Show member pathways
9.2CXCR5, CXCR3, CXCL13
13
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.2IRF4, BIRC2, BIRC3
14
Show member pathways
9.1BIRC3, TLR1, BIRC2
15
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.1TRB, IGH, ZAP70, IGHM
169.1BCL6, MALT1, ZAP70, BCL10
179.0BIRC3, MALT1, BCL10, BIRC2
18
Show member pathways
9.0TLR1, ZAP70, CXCL13, CXCR3
19
Show member pathways
8.9TLR1, MALT1, BIRC3, BIRC2
20
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.9TRB, MALT1, BCL10, ZAP70, IRF4
218.7CD5, ZAP70, BCL10, BCL6, IGHM
22
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.7BIRC2, TLR1, MALT1, BCL10, BIRC3
23
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
8.7BCL10, MALT1, BIRC2, TRB
24
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
8.7IGHM, IGH, MALT1, BCL10, TRB, ZAP70
258.7ZAP70, MALT1, BCL10, BIRC3, BIRC2
26
Show member pathways
8.3CXCL13, ZAP70, CXCR3, BIRC2, BIRC3
27
Show member pathways
8.0BIRC3, ZAP70, BIRC2, BCL10, IGHM, MADCAM1

Compounds for genes affiliated with Malt Lymphoma

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Sources:
44Novoseek, 28IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Malt Lymphoma according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1ciap1449.6BIRC2, BIRC3
2peg-10449.6CXCL13, CXCR5
3enterotoxin449.6ZAP70, TRB
4ciap2449.6BIRC2, BIRC3
5flagellin44 2810.6CXCR3, TLR1
6fludarabine44 50 1111.4BIRC2, ZAP70, BIRC3
7paraffin448.9CD5, BCL6, MALT1, TRB
8rituximab44 50 1110.9ZAP70, BCL6, BIRC2
9cyclophosphamide44 50 1110.9TRB, ZAP70, BCL6
10serine448.3ZAP70, BIRC3, BCL10, BCL6, CXCR3, DUSP5
11oligonucleotide448.2ZAP70, IGH, DUSP5, BIRC3, BIRC2, TRB
12tyrosine448.0DUSP5, CXCR3, BCL6, BIRC3, ZAP70, CD5
13calcium44 50 24 1110.7TRB, CXCR3, CD5, DUSP5, ZAP70, BIRC3

GO Terms for genes affiliated with Malt Lymphoma

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Cellular components related to Malt Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CBM complexGO:03244910.0MALT1, BCL10
2immunological synapseGO:0017729.9BCL10, ZAP70
3T cell receptor complexGO:0421019.6BCL10, ZAP70
4membrane raftGO:0451218.9BCL10, BIRC3, BIRC2, ZAP70
5plasma membraneGO:0058867.6IGHM, TLR1, CXCR5, CXCR3, MADCAM1, MALT1

Biological processes related to Malt Lymphoma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell receptor signaling pathwayGO:05085610.3BCL10, MALT1
2response to fungusGO:00962010.3BCL10, MALT1
3response to molecule of bacterial originGO:00223710.2BCL10, MALT1
4positive regulation of protein ubiquitinationGO:03139810.1MALT1, BCL10, BIRC3
5positive regulation of T cell activationGO:05087010.0BCL10, MALT1
6adaptive immune responseGO:00225010.0ZAP70, IGHM, BCL10
7T cell receptor signaling pathwayGO:0508529.8ZAP70, MALT1, BCL10
8regulation of RIG-I signaling pathwayGO:0395359.8BIRC2, BIRC3
9regulation of cysteine-type endopeptidase activityGO:20001169.8BIRC2, BIRC3
10regulation of nucleotide-binding oligomerization domain containing signaling pathwayGO:0704249.8BIRC3, BIRC2
11regulation of necroptotic processGO:0605449.7BIRC3, BIRC2
12regulation of toll-like receptor signaling pathwayGO:0341219.7BIRC3, BIRC2
13NIK/NF-kappaB signalingGO:0380619.7BIRC3, BIRC2
14B cell activationGO:0421139.7ZAP70, CXCR5
15necroptotic processGO:0702669.6BIRC2, BIRC3
16germinal center formationGO:0024679.5CXCL13, BCL6
17regulation of innate immune responseGO:0450889.5BIRC2, BIRC3
18lymph node developmentGO:0485359.4CXCR5, CXCL13
19positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.3MALT1, BCL10, BIRC3, BIRC2
20toll-like receptor signaling pathwayGO:0022249.3BIRC2, BIRC3, BCL10, TLR1
21regulation of inflammatory responseGO:0507279.1BIRC3, BCL6, BIRC2
22regulation of apoptotic processGO:0429818.9BIRC3, BIRC2, MALT1
23cell surface receptor signaling pathwayGO:0071668.9BIRC3, CXCR3, CXCL13, BIRC2
24immune responseGO:0069558.8TLR1, CXCR5, CXCL13, MADCAM1, ZAP70
25innate immune responseGO:0450878.8BIRC2, BCL10, BIRC3, MALT1, TLR1, IGHM

Molecular functions related to Malt Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activator activityGO:01920910.1MALT1, BCL10
2protein self-associationGO:0436219.7BCL10, MALT1
3C-X-C chemokine receptor activityGO:0164949.7CXCR5, CXCR3
4receptor activityGO:0048729.6TLR1, CXCR3, CD5
5protein bindingGO:0055156.5DUSP5, IRF4, CXCR5, BCL6, BCL10, BIRC3

Products for genes affiliated with Malt Lymphoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Malt Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet