MCID: MMM001
MIFTS: 56

Mammary Paget's Disease malady

Rare diseases, Reproductive diseases, Cancer diseases categories
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Summaries for Mammary Paget's Disease

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MalaCards based summary: Mammary Paget's Disease, also known as paget's disease of the nipple, is related to secretory meningioma and cystadenoma. An important gene associated with Mammary Paget's Disease is KRT14 (keratin 14), and among its related pathways are SHC1 events in ERBB2 signaling and Alzheimers Disease Pathway. The drugs calcitonin and salmon calcitonin and the compounds methyltrienolone and capecitabine have been mentioned in the context of this disorder. Affiliated tissues include breast and bone, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Mammary Paget's Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 39NCIt, 63UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Mammary Paget's Disease, Aliases & Descriptions:

Name: Mammary Paget's Disease 8 42
Paget's Disease of the Nipple 42 48 62
Paget's Disease of the Breast 8 62
Paget's Disease, Mammary 42 62
Paget Disease of the Nipple 48
Paget Disease of the Breast 42
Mammary Pagets Disease 10
 
Pagets Disease Mammary 44
Mammary Paget Disease 8
Paget's Cell Neoplasm 62
Paget Cell Neoplasm 8
Osteitis Deformans 62
Paget's Disease 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

48
paget's disease of the nipple:
Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:3443
NCIt39 C7073
UMLS via Orphanet63 C1704323, C0030185
MESH via Orphanet35 D010144
ICD10 via Orphanet26 C50.0
ICD1025 M88.9

Related Diseases for Mammary Paget's Disease

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Diseases related to Mammary Paget's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1secretory meningioma10.5KRT7
2cystadenoma10.5KRT7
3breast fibroadenoma10.4PGR
4adenosarcoma10.4PGR
5bowen syndrome10.3KRT7, KRT14
6thymus cancer10.3KRT18, KRT7
7epithelioid sarcoma10.3KRT8, KRT7
8pancreatic ductal carcinoma10.3KRT7, KRT8
9cirrhosis, noncryptogenic10.3KRT18, KRT8
10liver cirrhosis10.3KRT8, KRT18
11craniopharyngioma10.3KRT14, KRT8
12sertoli-leydig cell tumor10.3KRT7, PGR
13biliary tract neoplasm10.3EGFR, ERBB2
14cervical squamous cell carcinoma10.3KRT14, KRT8
15intestinal obstruction10.3CFTR
16sex cord-gonadal stromal tumor10.2PGR, KRT7
17abrikosov's tumor10.2KRT7, KRT8
18bronchiolo-alveolar adenocarcinoma10.2KRT7, EGFR
19alcoholic hepatitis10.2KRT18, KRT8
20gallbladder cancer10.2KRT8, KRT7
21li-fraumeni syndrome10.2PGR, ERBB2
22paget disease, extramammary10.2
23synovial sarcoma10.2KRT8, KRT7, KRT14
24factor vii deficiency10.2EGFR, ERBB2
25angiosarcoma10.2KRT8, KRT14, KRT18
26mucoepidermoid carcinoma10.2EGFR, KRT7, KRT14
27autoimmune hepatitis10.2KRT8, KRT18
28breast cancer, invasive ductal10.1KRT14, ERBB2, PGR
29sertoli cell tumor10.1PGR, AR
30gastric adenocarcinoma10.1ERBB2, KRT8, KRT7
31neuroendocrine carcinoma10.1KRT7, KRT8, KRT18
32malignant mixed mullerian tumor10.1ERBB2, KRT7, PGR
33tubular adenocarcinoma10.1KRT7, ERBB2, PGR
34large cell carcinoma10.1ERBB2, EGFR, KRT7
35endometrial carcinoma10.1PGR, ERBB2, KRT7
36bladder carcinoma10.1ERBB2, KRT18, KRT8
37fibromatosis10.1PGR, AR
38bladder carcinoma in situ10.1ERBB2, EGFR
39gynecomastia10.1PGR, AR
40cutaneous paget's disease10.1KRT7, AR, ERBB2
41cervical adenocarcinoma10.1PGR, KRT8, KRT7
42non-small cell lung carcinoma10.1EGFR, ERBB2, KRT18
43inflammatory breast carcinoma10.1EGFR, PGR, ERBB2
44pancreatic cancer10.0KRT7, EGFR, KRT8
45lung cancer10.0ERBB2, EGFR, KRT7
46salivary gland adenoid cystic carcinoma10.0KRT7, KRT14, ERBB2, KRT8
47male breast cancer10.0AR, ERBB2, PGR
48chordoma10.0KRT18, KRT7, KRT14, KRT8
49ameloblastoma10.0KRT8, KRT14, KRT18, KRT7
50oxyphilic adenoma10.0KRT7, KRT18, KRT8, KRT14

Graphical network of the top 20 diseases related to Mammary Paget's Disease:



Diseases related to mammary paget's disease

Symptoms for Mammary Paget's Disease

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Drugs & Therapeutics for Mammary Paget's Disease

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Drug clinical trials:

Search ClinicalTrials for Mammary Paget's Disease

Search NIH Clinical Center for Mammary Paget's Disease

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Mammary Paget's Disease

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Anatomical Context for Mammary Paget's Disease

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MalaCards organs/tissues related to Mammary Paget's Disease:

32
Breast, Bone

Animal Models for Mammary Paget's Disease or affiliated genes

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MGI Mouse Phenotypes related to Mammary Paget's Disease:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7PGR, ERBB2, KRT14, EGFR, AR
2MP:00053708.4CFTR, KRT8, KRT18, EGFR, AR
3MP:00053808.4PGR, ERBB2, KRT8, KRT18, EGFR, AR
4MP:00053818.4CFTR, ERBB2, KRT8, KRT14, EGFR, AR
5MP:00053878.1AR, EGFR, KRT14, KRT8, PGR, CFTR
6MP:00053898.0CFTR, PGR, ERBB2, KRT8, KRT14, EGFR
7MP:00053977.8CFTR, PGR, KRT8, KRT14, EGFR, AR
8MP:00053787.7CFTR, ERBB2, KRT8, KRT14, KRT18, EGFR
9MP:00053847.7CFTR, PGR, ERBB2, KRT14, KRT7, EGFR
10MP:00107687.7CFTR, PGR, ERBB2, KRT8, KRT14, KRT18
11MP:00028737.7CFTR, LALBA, PGR, ERBB2, EGFR, AR
12MP:00107717.4LALBA, PGR, CSN3, ERBB2, KRT14, EGFR
13MP:00053797.2AR, CFTR, LALBA, PGR, CSN3, ERBB2

Publications for Mammary Paget's Disease

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Articles related to Mammary Paget's Disease:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Urothelial bladder carcinoma metastasising to the scrotum mimicking primary extra-mammary Paget's disease. (24614713)
2014
2
Minimally invasive mammary Paget's disease without an underlying breast carcinoma. (23851623)
2013
3
Pigmented mammary Paget's disease presenting with dermoscopic features of multiple dots. (23865386)
2013
4
A rare presentation of mammary Paget's disease involving the entire breast in the absence of any underlying ductal malignancy. (23760322)
2013
5
An Unusual Case of Mammary Paget's Disease Diagnosed Using Dynamic Contrast-Enhanced MRI. (23607031)
2013
6
Superficial sebaceous carcinoma on the areola clinically mimicking mammary Paget's disease. (23078184)
2013
7
Extra mammary Paget's disease of the vulva. (23372329)
2012
8
Pigmented mammary Paget's disease mimicking melanoma: report of three cases. (22064040)
2012
9
Characteristics of mammary Paget's disease in China: a national-wide multicenter retrospective study during 1999-2008. (22901142)
2012
10
Keratin Expression in Mammary Paget's Disease in situ with Intraductal Invasion. (23525171)
2012
11
A hyperpigmented plaque on the right nipple: a quiz. Pigmented mammary Paget's disease. (21369688)
2011
12
Cystic fibrosis transmembrane conductance regulator is helpful in the distinction of extra-mammary Paget's disease from squamous cell carcinoma in situ (Bowen's disease). (21352263)
2011
13
Extra-mammary Paget's disease of the perianal region: a review of the literature emphasizing the operative management technique. (20884199)
2011
14
A case report of pigmented mammary Paget's disease mimicking nevus of the nipple. (21213079)
2011
15
Effectiveness of photodynamic therapy for mammary and extra-mammary Paget's disease: a state of the science review. (21676258)
2011
16
Mammary Paget's disease and extra-mammary Paget's disease: two morphologically similar but biologically different diseases. (19719834)
2010
17
Different panels of markers should be used to predict mammary Paget's disease associated with in situ or invasive ductal carcinoma of the breast. (19201736)
2009
18
Pigmented mammary Paget's disease presenting as an enlarged areola. (19601948)
2009
19
Extra-mammary Paget's disease of the scrotum and penis: a case report. (20184077)
2009
20
Pigmented mammary Paget's disease: not a melanoma. (19413640)
2009
21
Pigmented mammary Paget's disease mimicking melanoma a further case in a man. (19470138)
2009
22
Clinicopathologic evaluation of mammary Paget's disease. (19967013)
2008
23
Allergic contact dermatitis mimicking mammary paget's disease. (19882019)
2008
24
Acinar pattern of mammary Paget's disease: a case report. (17760678)
2007
25
Quadruple extra-mammary Paget's disease. (17225023)
2007
26
Extensive mammary Paget's disease. (17397359)
2007
27
Pigmented mammary Paget's disease. (17567331)
2007
28
Mammary Paget's disease occurring after mastectomy. (16899115)
2006
29
Cytokeratin 7 staining was useful in a case of pigmented mammary Paget's disease resembling malignant melanoma. (17040462)
2006
30
Pigmented mammary Paget's disease mimicking melanoma. (15057051)
2004
31
Pigmented mammary Paget's disease in a man. (15032027)
2003
32
The ectopic expression of gastric mucin in extramammary and mammary Paget's disease. (11979091)
2002
33
Morphological evidence for field effect as a mechanism for tumour spread in mammary Paget's disease. (10583581)
1999
34
Mammary Paget's disease: evidence of diverse origin of the disease with a subgroup of Paget's disease developing from the superficial portion of lactiferous duct and a discontinuous pattern of tumor spread. (10594841)
1999
35
Mammary Paget's disease with acantholytic features and without any detectable breast tumor. (10089077)
1998
36
Underlying pathology in mammary Paget's disease. (9181226)
1997
37
Human papilloma virus DNA: a factor in the pathogenesis of mammary Paget's disease? (8932876)
1996
38
Mammary Paget's disease confined to the areola and associated with multifocal Toker cell hyperplasia. (8599455)
1995
39
A case of mammary Paget's disease without an underlying carcinoma: microscopic analysis of the DNA content in Paget cells. (8014269)
1994
40
Mammary Paget's disease and associated carcinoma. An immunohistochemical study. (7680194)
1993
41
Stump the experts. Extra-mammary Paget's disease in the perianal region. (2157742)
1990
42
Study of neu-protein expression in mammary Paget's disease with and without underlying breast carcinoma and in extramammary Paget's disease. (1701961)
1990
43
Extra-mammary Paget's disease of the penis. (2537673)
1989
44
Mammary Paget's disease and intraductal carcinoma. Histologic, histochemical, and immunocytochemical comparison. (2466419)
1988
45
Mammary Paget's disease without underlying carcinoma. (3026196)
1985
46
Immunohistochemical study of mammary and extra-mammary Paget's disease. (6098546)
1984
47
Unusual pulmonary metastasis of mammary cancer: unilateral pulmonary fibrosis after mammary Paget's disease. (4376192)
1974
48
MAMMARY PAGET'S DISEASE. (14179983)
1964
49
Extra-mammary Paget's disease; discussion of pathogenesis. (14892969)
1952
50
Findings in a case of extra-mammary Paget's disease. (14783970)
1950

Variations for Mammary Paget's Disease

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Expression for genes affiliated with Mammary Paget's Disease

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Expression patterns in normal tissues for genes affiliated with Mammary Paget's Disease

Search GEO for disease gene expression data for Mammary Paget's Disease.

Pathways for genes affiliated with Mammary Paget's Disease

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Pathways related to Mammary Paget's Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7EGFR, ERBB2
29.7EGFR, ERBB2
39.7ERBB2, EGFR
49.3KRT18, KRT7, KRT8
5
Show member pathways
9.3PGR, ERBB2, EGFR
6
Show member pathways
Signaling Pathways in Glioblastoma37
9.2AR, EGFR, ERBB2
7
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.2AR, EGFR, ERBB2
89.2AR, EGFR, ERBB2
99.2ERBB2, EGFR, AR
10
Show member pathways
9.2ERBB2, EGFR, AR
11
Show member pathways
9.2EGFR, ERBB2, CFTR
129.0KRT18, KRT7, KRT14, KRT8
138.8EGFR, KRT18, KRT7, KRT8

Compounds for genes affiliated with Mammary Paget's Disease

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Compounds related to Mammary Paget's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1methyltrienolone28 1110.9PGR, AR
2capecitabine44 50 1111.6PGR, ERBB2, EGFR
3anastrozole44 50 1111.6PGR, EGFR, ERBB2
4taxane449.6PGR, ERBB2, EGFR
5hematoxylin449.4KRT14, KRT7, KRT8, KRT18
6leucovorin44 50 1111.4ERBB2, PGR, EGFR
7exemestane44 50 61 1112.3ERBB2, EGFR, AR, PGR
8lapatinib44 50 1111.3AR, EGFR, ERBB2, PGR
9letrozole44 50 61 1112.3AR, EGFR, ERBB2, PGR
10progestin449.2PGR, AR, EGFR, ERBB2
11geldanamycin44 50 61 1112.2EGFR, AR, PGR, ERBB2
12formaldehyde44 2410.2KRT7, CFTR, ERBB2, KRT18
13trastuzumab44 50 1111.2EGFR, ERBB2, PGR
145fluorouracil449.2EGFR, PGR, KRT18, ERBB2
15gnrh449.2ERBB2, PGR, CFTR, AR
16vitamin a44 24 1111.1KRT14, KRT7, AR, PGR
17mg 13244 6110.1EGFR, AR, CFTR, KRT18
18butyrate449.1CFTR, KRT8, KRT14, KRT18
19curcumin449.1CFTR, ERBB2, AR, EGFR
20matrigel449.0AR, KRT18, KRT7, KRT8
21fulvestrant44 50 28 1112.0AR, EGFR, KRT18, PGR, ERBB2
22docetaxel44 50 61 1112.0PGR, KRT18, ERBB2, EGFR, AR
23cisplatin44 50 61 1111.9EGFR, CFTR, ERBB2, KRT8, KRT14
24n acetylcysteine448.9EGFR, KRT18, CFTR, AR, ERBB2
25n-acetylglucosamine448.8KRT7, KRT18, LALBA, KRT8
26cycloheximide448.8EGFR, PGR, AR, KRT8, ERBB2
27vitamin d448.7KRT14, CFTR, ERBB2, AR
28dexamethasone44 50 28 1111.7CFTR, ERBB2, KRT18, AR, PGR
29tamoxifen44 50 28 1111.7EGFR, AR, ERBB2, PGR, KRT14, KRT8
30agar448.6PGR, AR, EGFR, KRT18, ERBB2, KRT8
31sodium dodecylsulfate448.6LALBA, AR, PGR, CSN3
32urea44 24 1110.5LALBA, KRT14, KRT18, KRT8, CSN3
33genistein44 28 61 2 24 1113.5CFTR, PGR, ERBB2, AR, KRT8, EGFR
34lactose44 119.4CSN3, LALBA, CFTR, KRT7
35ethanol44 50 24 1111.4KRT18, KRT8, LALBA, CSN3
36steroid448.3AR, KRT18, KRT8, ERBB2, LALBA, PGR
37alanine448.3CFTR, LALBA, KRT18, PGR, ERBB2, KRT14
38aspartate448.2KRT18, AR, PGR, LALBA, CFTR, ERBB2
39doxorubicin44 50 1110.2KRT18, AR, EGFR, KRT8, CFTR, PGR
40serine448.2KRT18, KRT8, KRT14, EGFR, CFTR, AR
41retinoid448.1KRT18, AR, PGR, KRT8, KRT7, KRT14
42vegf448.1KRT18, KRT7, ERBB2, PGR, KRT8, AR
43iron44 249.0LALBA, CSN3, KRT7, KRT14, KRT8, KRT18
44glucose447.8CSN3, KRT8, KRT14, KRT7, KRT18, LALBA
45retinoic acid44 248.7KRT18, AR, EGFR, KRT8, PGR, CFTR
46testosterone44 61 24 1110.7PGR, CFTR, KRT8, AR, EGFR, KRT18
47tyrosine447.7EGFR, KRT18, KRT7, KRT14, ERBB2, LALBA
48paraffin447.4KRT8, PGR, CFTR, ERBB2, KRT14, KRT7
49progesterone44 28 61 24 1111.0EGFR, KRT18, KRT7, AR, KRT8, ERBB2
50estrogen446.6KRT14, ERBB2, KRT18, EGFR, AR, PGR

GO Terms for genes affiliated with Mammary Paget's Disease

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Cellular components related to Mammary Paget's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.2EGFR, ERBB2, CFTR
2basolateral plasma membraneGO:0163239.1CFTR, ERBB2, EGFR
3keratin filamentGO:0450959.1KRT18, KRT7, KRT14, KRT8
4intermediate filamentGO:0058829.0KRT18, KRT7, KRT14, KRT8
5cytoplasmGO:0057377.5ERBB2, KRT8, KRT14, KRT7, KRT18, EGFR

Biological processes related to Mammary Paget's Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1hepatocyte apoptotic processGO:09728410.0KRT18, KRT8
2positive regulation of transcription from RNA polymerase III promoterGO:04594510.0AR, ERBB2
3tumor necrosis factor-mediated signaling pathwayGO:0332099.9KRT18, KRT8
4extrinsic apoptotic signaling pathwayGO:0971919.7KRT8, KRT18
5positive regulation of phosphorylationGO:0423279.7AR, EGFR
6positive regulation of vasodilationGO:0459099.6CFTR, EGFR
7positive regulation of MAP kinase activityGO:0434069.4EGFR, ERBB2
8cell proliferationGO:0082839.2AR, EGFR, ERBB2
9cell-cell signalingGO:0072678.9AR, PGR, LALBA
10signal transductionGO:0071658.2LALBA, PGR, ERBB2, EGFR, AR

Molecular functions related to Mammary Paget's Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.8EGFR, ERBB2
2receptor signaling protein tyrosine kinase activityGO:0047169.7ERBB2, EGFR
3scaffold protein bindingGO:0971109.7KRT18, KRT8
4ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.7PGR, AR
5transmembrane receptor protein tyrosine kinase activityGO:0047149.4ERBB2, EGFR
6structural molecule activityGO:0051989.3KRT7, KRT18, KRT8
7enzyme bindingGO:0198998.9AR, PGR, CFTR, EGFR
8protein bindingGO:0055157.1ERBB2, PGR, CFTR, KRT8, KRT14, KRT7

Products for genes affiliated with Mammary Paget's Disease

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  • Antibodies
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Sources for Mammary Paget's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet