MCID: MMM001
MIFTS: 49

Mammary Paget's Disease malady

Rare diseases, Reproductive diseases, Cancer diseases categories

Summaries for Mammary Paget's Disease

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MalaCards based summary: Mammary Paget's Disease, also known as paget's disease of the nipple, is related to paget disease, extramammary and melanoma. An important gene associated with Mammary Paget's Disease is KRT14 (keratin 14), and among its related pathways are SHC1 events in ERBB2 signaling and Alzheimers Disease Pathway. The drugs calcitonin and salmon calcitonin and the compounds methyltrienolone and capecitabine have been mentioned in the context of this disorder. Affiliated tissues include breast and bone, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Mammary Paget's Disease

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 38NCIt, 61UMLS via Orphanet, 34MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Mammary Paget's Disease, Aliases & Descriptions:

Name: Mammary Paget's Disease 9 41
Paget's Disease of the Nipple 41 47 60
Paget Disease of the Nipple 41 47
Paget's Disease, Mammary 41 60
Paget's Disease 9 60
Paget's Disease of the Breast 9
Pagets Disease of the Nipple 41
 
Paget Disease of the Breast 41
Mammary Pagets Disease 11
Pagets Disease Mammary 43
Mammary Paget Disease 9
Paget Cell Neoplasm 9
Osteitis Deformans 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

47
paget's disease of the nipple:
Age of onset: Adult


External Ids:

Disease Ontology9 DOID:3443
NCIt38 C7073
Orphanet47 180275
UMLS via Orphanet61 C1704323, C0030185
MESH via Orphanet34 D010144
ICD10 via Orphanet26 C50.0
ICD1025 M88.9

Related Diseases for Mammary Paget's Disease

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Diseases related to Mammary Paget's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1paget disease, extramammary30.4AR, KRT7, ERBB2
2melanoma29.9KRT18, KRT14, KRT8, CFTR
3secretory meningioma10.5KRT7
4cystadenoma10.5KRT7
5breast fibroadenoma10.4PGR
6adenosarcoma10.4PGR
7bowen syndrome10.3KRT7, KRT14
8thymic carcinoma10.3KRT18, KRT7
9pancreatic ductal carcinoma10.3KRT8, KRT7
10epithelioid sarcoma10.3KRT8, KRT7
11liver cirrhosis10.3KRT8, KRT18
12cirrhosis, cryptogenic10.3KRT8, KRT18
13craniopharyngioma10.3KRT8, KRT14
14sertoli-leydig cell tumor10.3PGR, KRT7
15biliary tract neoplasm10.2ERBB2, EGFR
16cervical squamous cell carcinoma10.2KRT8, KRT14
17intestinal obstruction10.2CFTR
18breast disease10.2PGR, ERBB2
19sex cord-gonadal stromal tumor10.2KRT7, PGR
20abrikosov's tumor10.2KRT8, KRT7
21alcoholic hepatitis10.2KRT18, KRT8
22bronchiolo-alveolar adenocarcinoma10.2EGFR, KRT7
23gallbladder cancer10.2KRT7, KRT8
24li-fraumeni syndrome10.2ERBB2, PGR
25superficial spreading melanoma10.2
26sarcoma, synovial10.2KRT7, KRT14, KRT8
27factor vii deficiency10.2ERBB2, EGFR
28angiosarcoma10.1KRT18, KRT14, KRT8
29mucoepidermoid carcinoma10.1KRT14, KRT7, EGFR
30breast cancer10.1PGR, ERBB2, KRT14
31sertoli cell tumor10.1PGR, AR
32gastric adenocarcinoma10.1ERBB2, KRT8, KRT7
33neuroendocrine tumor10.1KRT18, KRT7, KRT8
34bladder cancer, somatic10.1EGFR, ERBB2
35autoimmune hepatitis10.1KRT18, KRT8
36malignant mixed mullerian tumor10.1PGR, ERBB2, KRT7
37tubular adenocarcinoma10.1PGR, ERBB2, KRT7
38large cell carcinoma10.1EGFR, KRT7, ERBB2
39endometrial cancer10.1KRT7, ERBB2, PGR
40fibromatosis10.1AR, PGR
41gynecomastia10.1PGR, AR
42cervical adenocarcinoma10.1PGR, KRT8, KRT7
43inflammatory breast carcinoma10.1EGFR, ERBB2, PGR
44pancreatic cancer10.0EGFR, KRT7, KRT8
45lung cancer10.0EGFR, KRT7, ERBB2
46salivary gland adenoid cystic carcinoma10.0ERBB2, KRT8, KRT14, KRT7
47chordoma10.0KRT8, KRT14, KRT7, KRT18
48ameloblastoma10.0KRT8, KRT14, KRT7, KRT18
49oxyphilic adenoma10.0KRT8, KRT14, KRT7, KRT18
50leiomyosarcoma10.0PGR, KRT8

Graphical network of the top 20 diseases related to Mammary Paget's Disease:



Diseases related to mammary paget's disease

Symptoms for Mammary Paget's Disease

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Drugs & Therapeutics for Mammary Paget's Disease

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Drug clinical trials:

Search ClinicalTrials for Mammary Paget's Disease

Search NIH Clinical Center for Mammary Paget's Disease

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Mammary Paget's Disease

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Anatomical Context for Mammary Paget's Disease

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MalaCards organs/tissues related to Mammary Paget's Disease:

31
Breast, Bone

Animal Models for Mammary Paget's Disease or affiliated genes

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MGI Mouse Phenotypes related to Mammary Paget's Disease:

35 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7PGR, ERBB2, KRT14, EGFR, AR
2MP:00053708.4CFTR, KRT8, KRT18, EGFR, AR
3MP:00053808.4PGR, ERBB2, KRT8, KRT18, EGFR, AR
4MP:00053818.4CFTR, ERBB2, KRT8, KRT14, EGFR, AR
5MP:00053878.1AR, EGFR, KRT14, KRT8, PGR, CFTR
6MP:00053898.0CFTR, PGR, ERBB2, KRT8, KRT14, EGFR
7MP:00053977.8CFTR, PGR, KRT8, KRT14, EGFR, AR
8MP:00053787.7CFTR, ERBB2, KRT8, KRT14, KRT18, EGFR
9MP:00053847.7CFTR, PGR, ERBB2, KRT14, KRT7, EGFR
10MP:00107687.7CFTR, PGR, ERBB2, KRT8, KRT14, KRT18
11MP:00028737.7CFTR, LALBA, PGR, ERBB2, EGFR, AR
12MP:00107717.4LALBA, PGR, CSN3, ERBB2, KRT14, EGFR
13MP:00053797.2AR, CFTR, LALBA, PGR, CSN3, ERBB2

Publications for Mammary Paget's Disease

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Articles related to Mammary Paget's Disease:

(show top 50)    (show all 54)
idTitleAuthorsYear
1
Extra Mammary Paget's Disease: A Rare Case Report. (25657432)
2015
2
Urothelial bladder carcinoma metastasising to the scrotum mimicking primary extra-mammary Paget's disease. (24614713)
2014
3
Minimally invasive mammary Paget's disease without an underlying breast carcinoma. (23851623)
2013
4
Pigmented mammary Paget's disease presenting with dermoscopic features of multiple dots. (23865386)
2013
5
A rare presentation of mammary Paget's disease involving the entire breast in the absence of any underlying ductal malignancy. (23760322)
2013
6
An Unusual Case of Mammary Paget's Disease Diagnosed Using Dynamic Contrast-Enhanced MRI. (23607031)
2013
7
Superficial sebaceous carcinoma on the areola clinically mimicking mammary Paget's disease. (23078184)
2013
8
Extra mammary Paget's disease of the vulva. (23372329)
2012
9
Pigmented mammary Paget's disease mimicking melanoma: report of three cases. (22064040)
2012
10
Characteristics of mammary Paget's disease in China: a national-wide multicenter retrospective study during 1999-2008. (22901142)
2012
11
A hyperpigmented plaque on the right nipple: a quiz. Pigmented mammary Paget's disease. (21369688)
2011
12
Cystic fibrosis transmembrane conductance regulator is helpful in the distinction of extra-mammary Paget's disease from squamous cell carcinoma in situ (Bowen's disease). (21352263)
2011
13
Extra-mammary Paget's disease of the perianal region: a review of the literature emphasizing the operative management technique. (20884199)
2011
14
A case report of pigmented mammary Paget's disease mimicking nevus of the nipple. (21213079)
2011
15
Effectiveness of photodynamic therapy for mammary and extra-mammary Paget's disease: a state of the science review. (21676258)
2011
16
Mammary Paget's disease and extra-mammary Paget's disease: two morphologically similar but biologically different diseases. (19719834)
2010
17
Different panels of markers should be used to predict mammary Paget's disease associated with in situ or invasive ductal carcinoma of the breast. (19201736)
2009
18
Pigmented mammary Paget's disease presenting as an enlarged areola. (19601948)
2009
19
Extra-mammary Paget's disease of the scrotum and penis: a case report. (20184077)
2009
20
Pigmented mammary Paget's disease: not a melanoma. (19413640)
2009
21
Pigmented mammary Paget's disease mimicking melanoma a further case in a man. (19470138)
2009
22
Clinicopathologic evaluation of mammary Paget's disease. (19967013)
2008
23
Immunohistochemical tracking of an immune response in mammary Paget's disease. (18842336)
2008
24
Allergic contact dermatitis mimicking mammary paget's disease. (19882019)
2008
25
Acinar pattern of mammary Paget's disease: a case report. (17760678)
2007
26
Quadruple extra-mammary Paget's disease. (17225023)
2007
27
Extensive mammary Paget's disease. (17397359)
2007
28
Pigmented mammary Paget's disease. (17567331)
2007
29
Mammary Paget's disease occurring after mastectomy. (16899115)
2006
30
Cytokeratin 7 staining was useful in a case of pigmented mammary Paget's disease resembling malignant melanoma. (17040462)
2006
31
Pigmented mammary Paget's disease mimicking melanoma. (15057051)
2004
32
Pigmented mammary Paget's disease in a man. (15032027)
2003
33
The ectopic expression of gastric mucin in extramammary and mammary Paget's disease. (11979091)
2002
34
Morphological evidence for field effect as a mechanism for tumour spread in mammary Paget's disease. (10583581)
1999
35
Mammary Paget's disease: evidence of diverse origin of the disease with a subgroup of Paget's disease developing from the superficial portion of lactiferous duct and a discontinuous pattern of tumor spread. (10594841)
1999
36
Mammary Paget's disease with acantholytic features and without any detectable breast tumor. (10089077)
1998
37
Underlying pathology in mammary Paget's disease. (9181226)
1997
38
Human papilloma virus DNA: a factor in the pathogenesis of mammary Paget's disease? (8932876)
1996
39
Mammary Paget's disease confined to the areola and associated with multifocal Toker cell hyperplasia. (8599455)
1995
40
Mammary Paget's disease and associated carcinoma. An immunohistochemical study. (7680194)
1993
41
Stump the experts. Extra-mammary Paget's disease in the perianal region. (2157742)
1990
42
Study of neu-protein expression in mammary Paget's disease with and without underlying breast carcinoma and in extramammary Paget's disease. (1701961)
1990
43
Extra-mammary Paget's disease of the penis. (2537673)
1989
44
Mammary Paget's disease and intraductal carcinoma. Histologic, histochemical, and immunocytochemical comparison. (2466419)
1988
45
Mammary Paget's disease without underlying carcinoma. (3026196)
1985
46
Immunohistochemical study of mammary and extra-mammary Paget's disease. (6098546)
1984
47
Unusual pulmonary metastasis of mammary cancer: unilateral pulmonary fibrosis after mammary Paget's disease. (4376192)
1974
48
MAMMARY PAGET'S DISEASE. (14179983)
1964
49
Extra-mammary Paget's disease; discussion of pathogenesis. (14892969)
1952
50
Findings in a case of extra-mammary Paget's disease. (14783970)
1950

Variations for Mammary Paget's Disease

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Expression for genes affiliated with Mammary Paget's Disease

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Search GEO for disease gene expression data for Mammary Paget's Disease.

Pathways for genes affiliated with Mammary Paget's Disease

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Pathways related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7EGFR, ERBB2
29.7EGFR, ERBB2
39.7ERBB2, EGFR
49.3KRT8, KRT7, KRT18
5
Show member pathways
9.3EGFR, ERBB2, PGR
6
Show member pathways
Signaling Pathways in Glioblastoma36
9.2AR, EGFR, ERBB2
7
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.2ERBB2, EGFR, AR
89.2ERBB2, EGFR, AR
99.2ERBB2, AR, EGFR
10
Show member pathways
9.2EGFR, ERBB2, AR
11
Show member pathways
9.2EGFR, ERBB2, CFTR
129.0KRT8, KRT14, KRT7, KRT18
138.8EGFR, KRT18, KRT7, KRT8

Compounds for genes affiliated with Mammary Paget's Disease

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Compounds related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1methyltrienolone28 1210.9PGR, AR
2capecitabine43 49 1211.6PGR, ERBB2, EGFR
3anastrozole43 49 1211.6PGR, EGFR, ERBB2
4taxane439.6PGR, ERBB2, EGFR
5hematoxylin439.4KRT14, KRT7, KRT8, KRT18
6leucovorin43 49 1211.4ERBB2, PGR, EGFR
7exemestane43 49 59 1212.3ERBB2, EGFR, AR, PGR
8lapatinib43 49 1211.3AR, EGFR, ERBB2, PGR
9letrozole43 49 59 1212.3AR, EGFR, ERBB2, PGR
10progestin439.2PGR, AR, EGFR, ERBB2
11geldanamycin43 49 59 1212.2EGFR, AR, PGR, ERBB2
12formaldehyde43 2410.2KRT7, CFTR, ERBB2, KRT18
13trastuzumab43 49 1211.2EGFR, ERBB2, PGR
145fluorouracil439.2EGFR, PGR, KRT18, ERBB2
15gnrh439.2ERBB2, PGR, CFTR, AR
16vitamin a43 24 1211.1KRT14, KRT7, AR, PGR
17mg 13243 5910.1EGFR, AR, CFTR, KRT18
18butyrate439.1CFTR, KRT8, KRT14, KRT18
19curcumin439.1CFTR, ERBB2, AR, EGFR
20matrigel439.0AR, KRT18, KRT7, KRT8
21fulvestrant43 49 28 1212.0AR, EGFR, KRT18, PGR, ERBB2
22docetaxel43 49 59 1212.0PGR, KRT18, ERBB2, EGFR, AR
23cisplatin43 49 59 1211.9EGFR, CFTR, ERBB2, KRT8, KRT14
24n acetylcysteine438.9EGFR, KRT18, CFTR, AR, ERBB2
25n-acetylglucosamine438.8KRT7, KRT18, LALBA, KRT8
26cycloheximide438.8EGFR, PGR, AR, KRT8, ERBB2
27vitamin d438.7KRT14, CFTR, ERBB2, AR
28dexamethasone43 49 28 1211.7CFTR, ERBB2, KRT18, AR, PGR
29tamoxifen43 49 28 1211.7EGFR, AR, ERBB2, PGR, KRT14, KRT8
30agar438.6PGR, AR, EGFR, KRT18, ERBB2, KRT8
31sodium dodecylsulfate438.6LALBA, AR, PGR, CSN3
32urea43 24 1210.5LALBA, KRT14, KRT18, KRT8, CSN3
33genistein43 28 59 2 24 1213.5CFTR, PGR, ERBB2, AR, KRT8, EGFR
34lactose43 129.4CSN3, LALBA, CFTR, KRT7
35ethanol43 49 24 1211.4KRT18, KRT8, LALBA, CSN3
36steroid438.3AR, KRT18, KRT8, ERBB2, LALBA, PGR
37alanine438.3CFTR, LALBA, KRT18, PGR, ERBB2, KRT14
38aspartate438.2KRT18, AR, PGR, LALBA, CFTR, ERBB2
39doxorubicin43 49 1210.2KRT18, AR, EGFR, KRT8, CFTR, PGR
40serine438.2KRT18, KRT8, KRT14, EGFR, CFTR, AR
41retinoid438.1KRT18, AR, PGR, KRT8, KRT7, KRT14
42vegf438.1KRT18, KRT7, ERBB2, PGR, KRT8, AR
43iron43 249.0LALBA, CSN3, KRT7, KRT14, KRT8, KRT18
44glucose437.8CSN3, KRT8, KRT14, KRT7, KRT18, LALBA
45retinoic acid43 248.7KRT18, AR, EGFR, KRT8, PGR, CFTR
46testosterone43 59 24 1210.7PGR, CFTR, KRT8, AR, EGFR, KRT18
47tyrosine437.7EGFR, KRT18, KRT7, KRT14, ERBB2, LALBA
48paraffin437.4KRT8, PGR, CFTR, ERBB2, KRT14, KRT7
49progesterone43 28 59 24 1211.0EGFR, KRT18, KRT7, AR, KRT8, ERBB2
50estrogen436.6KRT14, ERBB2, KRT18, EGFR, AR, PGR

GO Terms for genes affiliated with Mammary Paget's Disease

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Cellular components related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:00163249.2ERBB2, CFTR, EGFR
2basolateral plasma membraneGO:00163239.1EGFR, ERBB2, CFTR
3keratin filamentGO:00450959.1KRT8, KRT14, KRT7, KRT18
4intermediate filamentGO:00058829.0KRT8, KRT14, KRT7, KRT18
5cytoplasmGO:00057377.5ERBB2, EGFR, KRT18, KRT7, AR, KRT14

Biological processes related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1hepatocyte apoptotic processGO:009728410.0KRT18, KRT8
2positive regulation of transcription from RNA polymerase III promoterGO:004594510.0AR, ERBB2
3tumor necrosis factor-mediated signaling pathwayGO:00332099.9KRT18, KRT8
4extrinsic apoptotic signaling pathwayGO:00971919.7KRT8, KRT18
5positive regulation of phosphorylationGO:00423279.7AR, EGFR
6positive regulation of vasodilationGO:00459099.6CFTR, EGFR
7positive regulation of MAP kinase activityGO:00434069.4EGFR, ERBB2
8cell proliferationGO:00082839.2AR, EGFR, ERBB2
9cell-cell signalingGO:00072678.9AR, PGR, LALBA
10signal transductionGO:00071658.2LALBA, PGR, ERBB2, EGFR, AR

Molecular functions related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00050069.8EGFR, ERBB2
2receptor signaling protein tyrosine kinase activityGO:00047169.7EGFR, ERBB2
3scaffold protein bindingGO:00971109.7KRT18, KRT8
4ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00048799.7AR, PGR
5transmembrane receptor protein tyrosine kinase activityGO:00047149.4EGFR, ERBB2
6structural molecule activityGO:00051989.3KRT8, KRT7, KRT18
7enzyme bindingGO:00198998.9CFTR, PGR, EGFR, AR
8protein bindingGO:00055157.1CFTR, PGR, ERBB2, KRT8, KRT14, KRT7

Products for genes affiliated with Mammary Paget's Disease

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Sources for Mammary Paget's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet