MCID: MMM001
MIFTS: 55

Mammary Paget's Disease malady

Rare diseases, Reproductive diseases, Cancer diseases categories
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Summaries for Mammary Paget's Disease

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33MalaCards
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MalaCards: Mammary Paget's Disease, also known as paget's disease of the nipple, is related to paget disease, extramammary and secretory meningioma. An important gene associated with Mammary Paget's Disease is KRT14 (keratin 14), and among its related pathways are SHC1 events in ERBB2 signaling and Alzheimers Disease Pathway. The drugs calcitonin and salmon calcitonin and the compounds methyltrienolone and capecitabine have been mentioned in the context of this disorder. Affiliated tissues include breast and bone, and related mouse phenotypes are tumorigenesis and embryogenesis.

Aliases & Classifications for Mammary Paget's Disease

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Sources:
62UMLS, 8Disease Ontology, 43NIH Rare Diseases, 49Orphanet, 10DISEASES, 45Novoseek, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

49
paget's disease of the nipple:
Age of onset: Adulthood


Aliases & Descriptions:

mammary paget's disease 8 43
paget's disease of the nipple 43 49
paget's disease, mammary 43 62
paget's disease of the breast 8
paget disease of the nipple 49
paget disease of the breast 43
mammary pagets disease 10
pagets disease mammary 45
mammary paget disease 8
paget cell neoplasm 8
osteitis deformans 62
paget's disease 8


External Ids:

Disease Ontology8 DOID:3443
NCIt40 C7073
MESH via Orphanet36 D010144
ICD10 via Orphanet26 C50.0
SNOMED-CT via Orphanet59 2985005, 403946000
UMLS via Orphanet63 C0030185, C1704323
ICD1025 M88.9

Related Diseases for Mammary Paget's Disease

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17GeneCards, 18GeneDecks
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Diseases related to Mammary Paget's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1paget disease, extramammary10.2
2secretory meningioma10.1KRT7
3cystadenoma10.1KRT7
4breast fibroadenoma10.1PGR
5adenosarcoma10.1PGR
6bowen syndrome10.1KRT7, KRT14
7thymus cancer10.1KRT18, KRT7
8epithelioid sarcoma10.1KRT8, KRT7
9pancreatic ductal carcinoma10.1KRT7, KRT8
10cirrhosis, noncryptogenic10.1KRT18, KRT8
11liver cirrhosis10.1KRT8, KRT18
12craniopharyngioma10.1KRT14, KRT8
13sertoli-leydig cell tumor10.1KRT7, PGR
14biliary tract neoplasm10.1EGFR, ERBB2
15cervical squamous cell carcinoma10.1KRT14, KRT8
16intestinal obstruction10.1CFTR
17sex cord-gonadal stromal tumor10.1PGR, KRT7
18abrikosov's tumor10.1KRT7, KRT8
19bronchiolo-alveolar adenocarcinoma10.1KRT7, EGFR
20alcoholic hepatitis10.1KRT18, KRT8
21gallbladder cancer10.0KRT8, KRT7
22li-fraumeni syndrome10.0PGR, ERBB2
23synovial sarcoma10.0KRT8, KRT7, KRT14
24factor vii deficiency10.0EGFR, ERBB2
25angiosarcoma10.0KRT8, KRT14, KRT18
26mucoepidermoid carcinoma10.0EGFR, KRT7, KRT14
27autoimmune hepatitis10.0KRT8, KRT18
28breast cancer, invasive ductal10.0KRT14, ERBB2, PGR
29sertoli cell tumor10.0PGR, AR
30gastric adenocarcinoma10.0ERBB2, KRT8, KRT7
31neuroendocrine carcinoma10.0KRT7, KRT8, KRT18
32malignant mixed mullerian tumor10.0ERBB2, KRT7, PGR
33tubular adenocarcinoma10.0KRT7, ERBB2, PGR
34large cell carcinoma10.0ERBB2, EGFR, KRT7
35endometrial carcinoma10.0PGR, ERBB2, KRT7
36bladder carcinoma10.0ERBB2, KRT18, KRT8
37fibromatosis10.0PGR, AR
38bladder carcinoma in situ10.0ERBB2, EGFR
39gynecomastia10.0PGR, AR
40cutaneous paget's disease10.0KRT7, AR, ERBB2
41cervical adenocarcinoma10.0PGR, KRT8, KRT7
42non-small cell lung carcinoma10.0EGFR, ERBB2, KRT18
43inflammatory breast carcinoma10.0EGFR, PGR, ERBB2
44pancreatic cancer10.0KRT7, EGFR, KRT8
45lung cancer10.0ERBB2, EGFR, KRT7
46adenoid cystic carcinoma10.0KRT7, KRT14, ERBB2, KRT8
47male breast cancer10.0AR, ERBB2, PGR
48chordoma10.0KRT18, KRT7, KRT14, KRT8
49adenoameloblastoma10.0KRT8, KRT14, KRT18, KRT7
50oxyphilic adenoma10.0KRT7, KRT18, KRT8, KRT14

Graphical network of the top 20 diseases related to Mammary Paget's Disease:



Diseases related to mammary paget's disease

Symptoms for Mammary Paget's Disease

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Drugs & Therapeutics for Mammary Paget's Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Mammary Paget's Disease

Search NIH Clinical Center for Mammary Paget's Disease

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Mammary Paget's Disease

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Anatomical Context for Mammary Paget's Disease

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33MalaCards
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MalaCards organs/tissues related to Mammary Paget's Disease:

33
Breast, Bone

Animal Models for Mammary Paget's Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Mammary Paget's Disease:

37 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7KRT14, AR, EGFR, ERBB2, PGR
2MP:00053808.4KRT18, ERBB2, KRT8, AR, PGR, EGFR
3MP:00053818.4ERBB2, CFTR, KRT8, KRT14, EGFR, AR
4MP:00053708.3CFTR, AR, EGFR, KRT18, KRT8
5MP:00053878.1AR, PGR, KRT8, KRT14, EGFR, CFTR
6MP:00053898.0EGFR, KRT14, KRT8, ERBB2, PGR, CFTR
7MP:00053787.8KRT14, CFTR, EGFR, AR, ERBB2, KRT18
8MP:00053977.8CFTR, EGFR, AR, KRT14, KRT8, PGR
9MP:00053847.7PGR, CFTR, ERBB2, KRT7, EGFR, AR
10MP:00107687.7CFTR, ERBB2, KRT8, KRT18, EGFR, KRT14
11MP:00028737.7AR, CFTR, PGR, LALBA, ERBB2, EGFR
12MP:00107717.4AR, EGFR, KRT14, ERBB2, CSN3, PGR
13MP:00053797.2LALBA, AR, EGFR, ERBB2, CSN3, PGR

Publications for Mammary Paget's Disease

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Sources:
52PubMed
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Articles related to Mammary Paget's Disease:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
Minimally invasive mammary Paget's disease without an underlying breast carcinoma. (23851623)
2013
2
Pigmented mammary Paget's disease presenting with dermoscopic features of multiple dots. (23865386)
2013
3
A rare presentation of mammary Paget's disease involving the entire breast in the absence of any underlying ductal malignancy. (23760322)
2013
4
An Unusual Case of Mammary Paget's Disease Diagnosed Using Dynamic Contrast-Enhanced MRI. (23607031)
2013
5
Superficial sebaceous carcinoma on the areola clinically mimicking mammary Paget's disease. (23078184)
2013
6
Extra mammary Paget's disease of the vulva. (23372329)
2012
7
Pigmented mammary Paget's disease mimicking melanoma: report of three cases. (22064040)
2012
8
Characteristics of mammary Paget's disease in China: a national-wide multicenter retrospective study during 1999-2008. (22901142)
2012
9
Keratin Expression in Mammary Paget's Disease in situ with Intraductal Invasion. (23525171)
2012
10
A hyperpigmented plaque on the right nipple: a quiz. Pigmented mammary Paget's disease. (21369688)
2011
11
Cystic fibrosis transmembrane conductance regulator is helpful in the distinction of extra-mammary Paget's disease from squamous cell carcinoma in situ (Bowen's disease). (21352263)
2011
12
Extra-mammary Paget's disease of the perianal region: a review of the literature emphasizing the operative management technique. (20884199)
2011
13
A case report of pigmented mammary Paget's disease mimicking nevus of the nipple. (21213079)
2011
14
Effectiveness of photodynamic therapy for mammary and extra-mammary Paget's disease: a state of the science review. (21676258)
2011
15
Mammary Paget's disease and extra-mammary Paget's disease: two morphologically similar but biologically different diseases. (19719834)
2010
16
Different panels of markers should be used to predict mammary Paget's disease associated with in situ or invasive ductal carcinoma of the breast. (19201736)
2009
17
Pigmented mammary Paget's disease presenting as an enlarged areola. (19601948)
2009
18
Extra-mammary Paget's disease of the scrotum and penis: a case report. (20184077)
2009
19
Pigmented mammary Paget's disease: not a melanoma. (19413640)
2009
20
Pigmented mammary Paget's disease mimicking melanoma a further case in a man. (19470138)
2009
21
Clinicopathologic evaluation of mammary Paget's disease. (19967013)
2008
22
Immunohistochemical tracking of an immune response in mammary Paget's disease. (18842336)
2008
23
Allergic contact dermatitis mimicking mammary paget's disease. (19882019)
2008
24
Acinar pattern of mammary Paget's disease: a case report. (17760678)
2007
25
Quadruple extra-mammary Paget's disease. (17225023)
2007
26
Extensive mammary Paget's disease. (17397359)
2007
27
Pigmented mammary Paget's disease. (17567331)
2007
28
Mammary Paget's disease occurring after mastectomy. (16899115)
2006
29
Cytokeratin 7 staining was useful in a case of pigmented mammary Paget's disease resembling malignant melanoma. (17040462)
2006
30
Pigmented mammary Paget's disease mimicking melanoma. (15057051)
2004
31
Pigmented mammary Paget's disease in a man. (15032027)
2003
32
The ectopic expression of gastric mucin in extramammary and mammary Paget's disease. (11979091)
2002
33
Morphological evidence for field effect as a mechanism for tumour spread in mammary Paget's disease. (10583581)
1999
34
Mammary Paget's disease: evidence of diverse origin of the disease with a subgroup of Paget's disease developing from the superficial portion of lactiferous duct and a discontinuous pattern of tumor spread. (10594841)
1999
35
Mammary Paget's disease with acantholytic features and without any detectable breast tumor. (10089077)
1998
36
Underlying pathology in mammary Paget's disease. (9181226)
1997
37
Mammary Paget's disease confined to the areola and associated with multifocal Toker cell hyperplasia. (8599455)
1995
38
A case of mammary Paget's disease without an underlying carcinoma: microscopic analysis of the DNA content in Paget cells. (8014269)
1994
39
Mammary Paget's disease and associated carcinoma. An immunohistochemical study. (7680194)
1993
40
Stump the experts. Extra-mammary Paget's disease in the perianal region. (2157742)
1990
41
Study of neu-protein expression in mammary Paget's disease with and without underlying breast carcinoma and in extramammary Paget's disease. (1701961)
1990
42
Extra-mammary Paget's disease of the penis. (2537673)
1989
43
Mucin-negative biopsy in extra-mammary Paget's disease. A diagnostic problem. (2478441)
1989
44
Mammary Paget's disease and intraductal carcinoma. Histologic, histochemical, and immunocytochemical comparison. (2466419)
1988
45
Mammary Paget's disease without underlying carcinoma. (3026196)
1985
46
Immunohistochemical study of mammary and extra-mammary Paget's disease. (6098546)
1984
47
Unusual pulmonary metastasis of mammary cancer: unilateral pulmonary fibrosis after mammary Paget's disease. (4376192)
1974
48
MAMMARY PAGET'S DISEASE. (14179983)
1964
49
Extra-mammary Paget's disease; discussion of pathogenesis. (14892969)
1952
50
Findings in a case of extra-mammary Paget's disease. (14783970)
1950

Variations for Mammary Paget's Disease

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Expression for genes affiliated with Mammary Paget's Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mammary Paget's Disease

Search GEO for disease gene expression data for Mammary Paget's Disease.

Pathways for genes affiliated with Mammary Paget's Disease

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Sources:
50PathCards, 55Reactome, 53QIAGEN, 38NCBI BioSystems Database, 5Cell Signaling Technology, 30KEGG, 60Thomson Reuters
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Pathways related to Mammary Paget's Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7EGFR, ERBB2
29.7EGFR, ERBB2
39.7ERBB2, EGFR
49.3KRT18, KRT7, KRT8
5
Show member pathways
9.3PGR, ERBB2, EGFR
6
Show member pathways
Signaling Pathways in Glioblastoma38
9.2AR, EGFR, ERBB2
7
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.2AR, EGFR, ERBB2
89.2AR, EGFR, ERBB2
99.2ERBB2, EGFR, AR
10
Show member pathways
9.2ERBB2, EGFR, AR
11
Show member pathways
9.2EGFR, ERBB2, CFTR
129.0KRT18, KRT7, KRT14, KRT8
138.8EGFR, KRT18, KRT7, KRT8

Compounds for genes affiliated with Mammary Paget's Disease

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29IUPHAR, 11DrugBank, 45Novoseek, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Mammary Paget's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1methyltrienolone29 1110.9PGR, AR
2capecitabine45 51 1111.6PGR, ERBB2, EGFR
3anastrozole45 51 1111.6PGR, EGFR, ERBB2
4taxane459.6PGR, ERBB2, EGFR
5hematoxylin459.4KRT14, KRT7, KRT8, KRT18
6leucovorin45 51 1111.4ERBB2, PGR, EGFR
7exemestane45 51 61 1112.3ERBB2, EGFR, AR, PGR
8lapatinib45 51 1111.3AR, EGFR, ERBB2, PGR
9letrozole45 51 61 1112.3AR, EGFR, ERBB2, PGR
10progestin459.2PGR, AR, EGFR, ERBB2
11geldanamycin45 51 61 1112.2EGFR, AR, PGR, ERBB2
12formaldehyde45 2410.2KRT7, CFTR, ERBB2, KRT18
13trastuzumab45 51 1111.2EGFR, ERBB2, PGR
145fluorouracil459.2EGFR, PGR, KRT18, ERBB2
15gnrh459.2ERBB2, PGR, CFTR, AR
16vitamin a45 24 1111.1KRT14, KRT7, AR, PGR
17mg 13245 6110.1EGFR, AR, CFTR, KRT18
18butyrate459.1CFTR, KRT8, KRT14, KRT18
19curcumin459.1CFTR, ERBB2, AR, EGFR
20matrigel459.0AR, KRT18, KRT7, KRT8
21fulvestrant45 51 29 1112.0AR, EGFR, KRT18, PGR, ERBB2
22docetaxel45 51 61 1112.0PGR, KRT18, ERBB2, EGFR, AR
23cisplatin45 51 61 1111.9EGFR, CFTR, ERBB2, KRT8, KRT14
24n acetylcysteine458.9EGFR, KRT18, CFTR, AR, ERBB2
25n-acetylglucosamine458.8KRT7, KRT18, LALBA, KRT8
26cycloheximide458.8EGFR, PGR, AR, KRT8, ERBB2
27vitamin d458.7KRT14, CFTR, ERBB2, AR
28dexamethasone45 51 29 1111.7CFTR, ERBB2, KRT18, AR, PGR
29tamoxifen45 51 29 1111.7EGFR, AR, ERBB2, PGR, KRT14, KRT8
30agar458.6PGR, AR, EGFR, KRT18, ERBB2, KRT8
31sodium dodecylsulfate458.6LALBA, AR, PGR, CSN3
32urea45 24 1110.5LALBA, KRT14, KRT18, KRT8, CSN3
33genistein45 29 61 3 24 1113.5CFTR, PGR, ERBB2, AR, KRT8, EGFR
34lactose45 119.4CSN3, LALBA, CFTR, KRT7
35ethanol45 51 24 1111.4KRT18, KRT8, LALBA, CSN3
36steroid458.3AR, KRT18, KRT8, ERBB2, LALBA, PGR
37alanine458.3CFTR, LALBA, KRT18, PGR, ERBB2, KRT14
38aspartate458.2KRT18, AR, PGR, LALBA, CFTR, ERBB2
39doxorubicin45 51 1110.2KRT18, AR, EGFR, KRT8, CFTR, PGR
40serine458.2KRT18, KRT8, KRT14, EGFR, CFTR, AR
41retinoid458.1KRT18, AR, PGR, KRT8, KRT7, KRT14
42vegf458.1KRT18, KRT7, ERBB2, PGR, KRT8, AR
43iron45 249.0LALBA, CSN3, KRT7, KRT14, KRT8, KRT18
44glucose457.8CSN3, KRT8, KRT14, KRT7, KRT18, LALBA
45retinoic acid45 248.7KRT18, AR, EGFR, KRT8, PGR, CFTR
46testosterone45 61 24 1110.7PGR, CFTR, KRT8, AR, EGFR, KRT18
47tyrosine457.7EGFR, KRT18, KRT7, KRT14, ERBB2, LALBA
48paraffin457.4KRT8, PGR, CFTR, ERBB2, KRT14, KRT7
49progesterone45 29 61 24 1111.0EGFR, KRT18, KRT7, AR, KRT8, ERBB2
50estrogen456.6KRT14, ERBB2, KRT18, EGFR, AR, PGR

GO Terms for genes affiliated with Mammary Paget's Disease

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Sources:
16Gene Ontology
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Cellular components related to Mammary Paget's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.2EGFR, ERBB2, CFTR
2basolateral plasma membraneGO:0163239.1CFTR, ERBB2, EGFR
3keratin filamentGO:0450959.1KRT18, KRT7, KRT14, KRT8
4intermediate filamentGO:0058829.0KRT18, KRT7, KRT14, KRT8
5cytoplasmGO:0057377.5ERBB2, KRT8, KRT14, KRT7, KRT18, EGFR

Biological processes related to Mammary Paget's Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1hepatocyte apoptotic processGO:09728410.0KRT8, KRT18
2positive regulation of transcription from RNA polymerase III promoterGO:04594510.0ERBB2, AR
3tumor necrosis factor-mediated signaling pathwayGO:0332099.9KRT18, KRT8
4extrinsic apoptotic signaling pathwayGO:0971919.7KRT18, KRT8
5positive regulation of phosphorylationGO:0423279.7EGFR, AR
6positive regulation of vasodilationGO:0459099.6EGFR, CFTR
7positive regulation of MAP kinase activityGO:0434069.4ERBB2, EGFR
8cell proliferationGO:0082839.2ERBB2, EGFR, AR
9cell-cell signalingGO:0072678.9AR, LALBA, PGR
10signal transductionGO:0071658.2AR, EGFR, ERBB2, PGR, LALBA

Molecular functions related to Mammary Paget's Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.8EGFR, ERBB2
2receptor signaling protein tyrosine kinase activityGO:0047169.7EGFR, ERBB2
3scaffold protein bindingGO:0971109.7KRT18, KRT8
4ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.7AR, PGR
5transmembrane receptor protein tyrosine kinase activityGO:0047149.4EGFR, ERBB2
6structural molecule activityGO:0051989.3KRT8, KRT7, KRT18
7enzyme bindingGO:0198998.9CFTR, PGR, EGFR, AR
8protein bindingGO:0055157.1CFTR, PGR, ERBB2, KRT8, KRT14, KRT7

Products for genes affiliated with Mammary Paget's Disease

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  • Antibodies
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Sources for Mammary Paget's Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet