MCID: MMM001
MIFTS: 45

Mammary Paget's Disease malady

Categories: Rare diseases, Reproductive diseases, Cancer diseases

Aliases & Classifications for Mammary Paget's Disease

Aliases & Descriptions for Mammary Paget's Disease:

Name: Mammary Paget's Disease 12 50 14
Paget's Disease 12 14 69
Paget's Disease of the Nipple 50 56
Paget Disease of the Breast 50 56
Paget's Disease, Mammary 50 69
Mammary Paget Disease 12 56
Paget's Disease of the Breast 12
Paget Disease of the Nipple 56
Pagets Disease Mammary 52
Paget Cell Neoplasm 12
Osteitis Deformans 69

Characteristics:

Orphanet epidemiological data:

56
paget disease of the nipple
Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:3443
NCIt 47 C7073
Orphanet 56 ORPHA180275
MESH via Orphanet 43 D010144
UMLS via Orphanet 70 C0030185 C1704323
ICD10 via Orphanet 34 C50.0
ICD10 33 M88.9
UMLS 69 C1368019

Summaries for Mammary Paget's Disease

MalaCards based summary : Mammary Paget's Disease, also known as paget's disease, is related to paget disease, extramammary and renal infectious disease, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Mammary Paget's Disease is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Aredia and Medroxyprogesterone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast and bone, and related phenotypes are mortality/aging and digestive/alimentary

Related Diseases for Mammary Paget's Disease

Diseases related to Mammary Paget's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
id Related Disease Score Top Affiliating Genes
1 paget disease, extramammary 11.2
2 renal infectious disease 10.3 ERBB2 KRT8
3 pineal region mature teratoma 10.3 EGFR ERBB2
4 occipital encephalocele 10.3 KRT18 KRT8
5 woolly hair, autosomal dominant 10.3 KRT18 KRT8
6 proteus-like syndrome 10.3 KRT18 KRT8
7 bartholin's gland adenoid cystic carcinoma 10.2 KRT18 KRT8
8 mouth disease 10.2 ERBB2 PGR
9 immunodeficiency due to a classical component pathway complement deficiency 10.2 EGFR MUC1
10 clear cell cystadenofibroma 10.2 KRT14 KRT8
11 mucoepidermoid thyroid carcinoma 10.2 ERBB2 PGR
12 agenesis and aplasia of uterine body 10.2 EGFR KRT20
13 mucinous cystadenocarcinoma 10.2 KRT18 MUC1
14 thymus squamous cell carcinoma 10.2 EGFR KRT14 KRT8
15 mental retardation, autosomal recessive 49 10.2 KRT14 KRT8
16 nasal cavity adenocarcinoma 10.2 ERBB2 KRT8 MUC1
17 lethal congenital contracture syndrome 10.2 EGFR MUC1
18 conjunctival cancer 10.2 KRT14 MUC1
19 spastic diplegia infantile type 10.2 EGFR ERBB2 MUC1
20 clitoris cancer 10.2 KRT20 MUC1
21 onychodystrophy-anonychia 10.2 KRT14 KRT18 KRT8
22 lacrimal gland mucoepidermoid carcinoma 10.2 MUC1 PGR
23 hereditary breast ovarian cancer 10.2 ERBB2 ESR1
24 anal margin basal cell carcinoma 10.2 KRT14 KRT20
25 ovarian cystadenocarcinoma 10.2 EGFR ERBB2
26 distal arthrogryposis 10.2 KRT14 KRT18 KRT8
27 bone chondrosarcoma 10.2 KRT14 KRT18 KRT8
28 exotropia 10.1 MUC1 PGR
29 pearson syndrome 10.1 EGFR ERBB2 MUC1
30 triple-receptor negative breast cancer 10.1 EGFR ERBB2 PGR
31 sarcomatoid mesothelioma 10.1 KRT18 KRT8 MUC1
32 skin sarcoma 10.1 EGFR ERBB2 PGR
33 facial dermatosis 10.1 EGFR ERBB2 MUC1
34 mediastinum angiosarcoma 10.1 ERBB2 KRT14 MUC1
35 marfanoid hypermobility syndrome 10.1 MUC1 PGR
36 reactive arthritis 10.1 EGFR ERBB2 PGR
37 immunodeficiency due to a late component of complement deficiency 10.1 EGFR ERBB2 PGR
38 endometrial stromal sarcoma 10.1 MUC1 PGR
39 cauda equina intradural extramedullary astrocytoma 10.1 KRT14 KRT18 MUC1
40 angiolipomatosis, familial 10.1 ERBB2 KRT20 MUC1
41 porokeratosis 10.1 MUC1 PGR
42 intestinal benign neoplasm 10.1 KRT20 KRT8 MUC1
43 bartholin's gland benign neoplasm 10.1 ESR1 PGR
44 allergic contact dermatitis 10.1 EGFR KRT20 MUC1
45 meige syndrome 10.1 KRT20 KRT8 MUC1
46 cardiovascular organ benign neoplasm 10.1 ESR1 PGR
47 appendix leiomyoma 10.1 ESR1 PGR
48 bronchus adenoma 10.1 ESR1 PGR
49 subependymal glioma 10.1 KRT14 KRT20 MUC1
50 ovarian benign neoplasm 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Mammary Paget's Disease:



Diseases related to Mammary Paget's Disease

Symptoms & Phenotypes for Mammary Paget's Disease

UMLS symptoms related to Mammary Paget's Disease:


back pain, muscle cramp, sciatica

MGI Mouse Phenotypes related to Mammary Paget's Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.81 CFTR EGFR ERBB2 ESR1 KRT14 KRT18
2 digestive/alimentary MP:0005381 9.8 CFTR EGFR ERBB2 ESR1 KRT14 KRT8
3 limbs/digits/tail MP:0005371 9.65 ERBB2 ESR1 PGR VCP EGFR
4 neoplasm MP:0002006 9.35 EGFR ERBB2 ESR1 KRT14 PGR
5 reproductive system MP:0005389 9.17 CFTR EGFR ERBB2 ESR1 KRT14 KRT8

Drugs & Therapeutics for Mammary Paget's Disease

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Aredia 17 46 PAMIDRONATE DISODIUM Chiron Approved August 1996

Drugs for Mammary Paget's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Medroxyprogesterone acetate Approved, Investigational Phase 3 71-58-9
2
Tamoxifen Approved Phase 3 10540-29-1 2733526
3
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
4
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
5
Epirubicin Approved Phase 3 56420-45-2 41867
6
Fluorouracil Approved Phase 3 51-21-8 3385
7
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
8
Obinutuzumab Approved Phase 3 949142-50-1
9
rituximab Approved Phase 3 174722-31-7 10201696
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
11
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
12 Antineoplastic Agents, Hormonal Phase 3
13 Bone Density Conservation Agents Phase 3
14 Contraceptive Agents Phase 3
15 Contraceptive Agents, Male Phase 3
16 Contraceptives, Oral Phase 3
17 Estrogen Antagonists Phase 3
18 Estrogen Receptor Modulators Phase 3
19 Estrogens Phase 3
20 Hormone Antagonists Phase 3,Phase 2
21 Hormones Phase 3,Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
23
Medroxyprogesterone Phase 3 520-85-4 10631
24 Selective Estrogen Receptor Modulators Phase 3
25 Alkylating Agents Phase 3,Phase 2
26 Antineoplastic Agents, Alkylating Phase 3,Phase 2
27 Antirheumatic Agents Phase 3,Phase 2
28 Immunosuppressive Agents Phase 3,Phase 2
29 Anti-Bacterial Agents Phase 3,Phase 2
30 Antibiotics, Antitubercular Phase 3,Phase 2
31 Antimetabolites Phase 3
32 Antimetabolites, Antineoplastic Phase 3
33 Dermatologic Agents Phase 3
34 Folic Acid Antagonists Phase 3
35 Nucleic Acid Synthesis Inhibitors Phase 3
36 Topoisomerase Inhibitors Phase 3,Phase 2
37 Vitamin B Complex Phase 3
38 Bendamustine Hydrochloride Phase 3
39 Citrate Nutraceutical Phase 3
40
Citric Acid Nutraceutical, Vet_approved Phase 3 77-92-9 311
41 Folate Nutraceutical Phase 3
42 Vitamin B9 Nutraceutical Phase 3
43
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
44
Melphalan Approved Phase 2 148-82-3 4053 460612
45
Thiotepa Approved Phase 2 52-24-4 5453
46
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
47
Dronabinol Approved, Illicit Phase 2 1972-08-3 16078 2978
48
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
49
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
50
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307

Interventional clinical trials:

(show all 12)
id Name Status NCT ID Phase
1 S9630, Medroxyprogesterone in Treating Women With Breast Cancer Completed NCT00002920 Phase 3
2 Combination Chemotherapy in Treating Patients With Early Stage Breast Cancer That Has Been Removed By Surgery Active, not recruiting NCT00301925 Phase 3
3 A Study of Obinutuzumab (RO5072759) Plus Chemotherapy in Comparison With Rituximab Plus Chemotherapy Followed by Obinutuzumab or Rituximab Maintenance in Patients With Untreated Advanced Indolent Non-Hodgkin's Lymphoma (GALLIUM) Active, not recruiting NCT01332968 Phase 3
4 Combination Chemotherapy With or Without Trastuzumab Followed By an Autologous Stem Cell Transplant and Radiation Therapy in Treating Patients With Stage III or Stage IV Breast Cancer Completed NCT00182793 Phase 2
5 Carboplatin or Docetaxel in Treating Women With Metastatic Genetic Breast Cancer Completed NCT00321633 Phase 2
6 A Study of Sativex® for Pain Relief in Patients With Advanced Malignancy. Completed NCT00530764 Phase 2
7 Docosahexaenoic Acid in Preventing Recurrence in Breast Cancer Survivors Active, not recruiting NCT01849250 Phase 2
8 Combination Chemotherapy With or Without Trastuzumab in Treating Patients With Stage II or Stage III Breast Cancer Active, not recruiting NCT00295893 Phase 2
9 Vaccine Therapy With or Without Sargramostim in Treating Patients With Advanced or Metastatic Cancer Completed NCT00028496 Phase 1
10 Vaccine Therapy in Treating Patients With Advanced or Metastatic Cancer Completed NCT00027534 Phase 1
11 Biological Therapy in Treating Patients With Metastatic Cancer Completed NCT00004604 Phase 1
12 Partial Breast Radiation Therapy in Treating Women Undergoing Breast Conservation Therapy for Early-Stage Breast Cancer Unknown status NCT00599989

Search NIH Clinical Center for Mammary Paget's Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Mammary Paget's Disease

Anatomical Context for Mammary Paget's Disease

MalaCards organs/tissues related to Mammary Paget's Disease:

39
Breast, Bone

Publications for Mammary Paget's Disease

Articles related to Mammary Paget's Disease:

(show top 50) (show all 58)
id Title Authors Year
1
Extra Mammary Paget's Disease of Vulva-a Case Report. ( 27872543 )
2016
2
Reflectance Confocal Microscopy for Diagnosis of Mammary Paget's Disease. ( 26976808 )
2016
3
Cytokeratin 7-negative mammary Paget's disease: A diagnostic pitfall. ( 26944832 )
2016
4
Extra Mammary Paget's Disease: A Rare Case Report. ( 25657432 )
2015
5
Double Rarities, Double Challenges: Extra-Mammary Paget's Disease and Anal Adenocarcinoma. ( 26233548 )
2015
6
Urothelial bladder carcinoma metastasising to the scrotum mimicking primary extra-mammary Paget's disease. ( 24614713 )
2014
7
A rare presentation of mammary Paget's disease involving the entire breast in the absence of any underlying ductal malignancy. ( 23760322 )
2013
8
Minimally invasive mammary Paget's disease without an underlying breast carcinoma. ( 23851623 )
2013
9
Superficial sebaceous carcinoma on the areola clinically mimicking mammary Paget's disease. ( 23078184 )
2013
10
Pigmented mammary Paget's disease presenting with dermoscopic features of multiple dots. ( 23865386 )
2013
11
An Unusual Case of Mammary Paget's Disease Diagnosed Using Dynamic Contrast-Enhanced MRI. ( 23607031 )
2013
12
Extra mammary Paget's disease of the vulva. ( 23372329 )
2012
13
Pigmented mammary Paget's disease mimicking melanoma: report of three cases. ( 22064040 )
2012
14
Keratin Expression in Mammary Paget's Disease in situ with Intraductal Invasion. ( 23525171 )
2012
15
Characteristics of mammary Paget's disease in China: a national-wide multicenter retrospective study during 1999-2008. ( 22901142 )
2012
16
Extra-mammary Paget's disease of the perianal region: a review of the literature emphasizing the operative management technique. ( 20884199 )
2011
17
Effectiveness of photodynamic therapy for mammary and extra-mammary Paget's disease: a state of the science review. ( 21676258 )
2011
18
A case report of pigmented mammary Paget's disease mimicking nevus of the nipple. ( 21213079 )
2011
19
Cystic fibrosis transmembrane conductance regulator is helpful in the distinction of extra-mammary Paget's disease from squamous cell carcinoma in situ (Bowen's disease). ( 21352263 )
2011
20
A hyperpigmented plaque on the right nipple: a quiz. Pigmented mammary Paget's disease. ( 21369688 )
2011
21
Mammary Paget's disease and extra-mammary Paget's disease: two morphologically similar but biologically different diseases. ( 19719834 )
2010
22
Pigmented mammary Paget's disease presenting as an enlarged areola. ( 19601948 )
2009
23
Different panels of markers should be used to predict mammary Paget's disease associated with in situ or invasive ductal carcinoma of the breast. ( 19201736 )
2009
24
Pigmented mammary Paget's disease mimicking melanoma a further case in a man. ( 19470138 )
2009
25
Pigmented mammary Paget's disease: not a melanoma. ( 19413640 )
2009
26
Pigmented spots as a sign of mammary Paget's disease. ( 18627392 )
2009
27
Extra-mammary Paget's disease of the scrotum and penis: a case report. ( 20184077 )
2009
28
Immunohistochemical tracking of an immune response in mammary Paget's disease. ( 18842336 )
2008
29
Allergic contact dermatitis mimicking mammary paget's disease. ( 19882019 )
2008
30
Clinicopathologic evaluation of mammary Paget's disease. ( 19967013 )
2008
31
Pigmented mammary Paget's disease. ( 17567331 )
2007
32
Extensive mammary Paget's disease. ( 17397359 )
2007
33
Acinar pattern of mammary Paget's disease: a case report. ( 17760678 )
2007
34
Quadruple extra-mammary Paget's disease. ( 17225023 )
2007
35
Cytokeratin 7 staining was useful in a case of pigmented mammary Paget's disease resembling malignant melanoma. ( 17040462 )
2006
36
Mammary Paget's disease occurring after mastectomy. ( 16899115 )
2006
37
Pigmented mammary Paget's disease mimicking melanoma. ( 15057051 )
2004
38
Pigmented mammary Paget's disease in a man. ( 15032027 )
2003
39
The ectopic expression of gastric mucin in extramammary and mammary Paget's disease. ( 11979091 )
2002
40
Mammary Paget's disease: evidence of diverse origin of the disease with a subgroup of Paget's disease developing from the superficial portion of lactiferous duct and a discontinuous pattern of tumor spread. ( 10594841 )
1999
41
Morphological evidence for field effect as a mechanism for tumour spread in mammary Paget's disease. ( 10583581 )
1999
42
Mammary Paget's disease with acantholytic features and without any detectable breast tumor. ( 10089077 )
1998
43
Underlying pathology in mammary Paget's disease. ( 9181226 )
1997
44
Human papilloma virus DNA: a factor in the pathogenesis of mammary Paget's disease? ( 8932876 )
1996
45
Mammary Paget's disease confined to the areola and associated with multifocal Toker cell hyperplasia. ( 8599455 )
1995
46
A case of mammary Paget's disease without an underlying carcinoma: microscopic analysis of the DNA content in Paget cells. ( 8014269 )
1994
47
Mammary Paget's disease and associated carcinoma. An immunohistochemical study. ( 7680194 )
1993
48
Stump the experts. Extra-mammary Paget's disease in the perianal region. ( 2157742 )
1990
49
Study of neu-protein expression in mammary Paget's disease with and without underlying breast carcinoma and in extramammary Paget's disease. ( 1701961 )
1990
50
Extra-mammary Paget's disease of the penis. ( 2537673 )
1989

Variations for Mammary Paget's Disease

Expression for Mammary Paget's Disease

Search GEO for disease gene expression data for Mammary Paget's Disease.

Pathways for Mammary Paget's Disease

GO Terms for Mammary Paget's Disease

Cellular components related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.56 CFTR EGFR ERBB2 MUC1
2 keratin filament GO:0045095 9.5 KRT14 KRT18 KRT8
3 cytoplasm GO:0005737 9.4 CALCA CFTR EGFR ERBB2 ESR1 KRT14
4 cell periphery GO:0071944 9.33 KRT14 KRT18 KRT8
5 intermediate filament GO:0005882 9.26 KRT14 KRT18 KRT20 KRT8
6 nucleus GO:0005634 10.07 CALCA EGFR ERBB2 ESR1 KRT14 KRT18

Biological processes related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of vasodilation GO:0045909 9.37 CALCA EGFR
2 regulation of ERK1 and ERK2 cascade GO:0070372 9.32 EGFR ERBB2
3 negative regulation of ERBB signaling pathway GO:1901185 9.26 EGFR ERBB2
4 keratinization GO:0031424 9.26 KRT14 KRT18 KRT20 KRT8
5 hepatocyte apoptotic process GO:0097284 9.16 KRT18 KRT8
6 cornification GO:0070268 8.92 KRT14 KRT18 KRT20 KRT8

Molecular functions related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.77 CALCA EGFR ERBB2 ESR1 VCP
2 enzyme binding GO:0019899 9.62 CFTR EGFR ESR1 PGR
3 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.16 EGFR ERBB2
4 protein phosphatase binding GO:0019903 9.13 EGFR ERBB2 VCP
5 nitric-oxide synthase regulator activity GO:0030235 8.62 EGFR ESR1
6 protein binding GO:0005515 10.03 CALCA CFTR EGFR ERBB2 ESR1 KRT14

Sources for Mammary Paget's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....