MCID: MMM001
MIFTS: 46

Mammary Paget's Disease malady

Reproductive, Cancer categories

Summaries for Mammary Paget's Disease

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33MalaCards
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MalaCards: Mammary Paget's Disease, also known as paget's disease of the nipple, is related to paget's disease of bone and osteitis fibrosa. An important gene associated with Mammary Paget's Disease is KRT14 (keratin 14), and among its related pathways are Osteoblast Signaling and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drugs calcitonin and salmon calcitonin and the compounds estrogen and clodronate have been mentioned in the context of this disorder. Affiliated tissues include skin and breast, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Mammary Paget's Disease

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Reproductive


Aliases & Descriptions:

mammary paget's disease 8 43
paget's disease of the nipple 43 49
paget's disease, mammary 43 61
paget's disease of the breast 8
paget disease of the breast 43
paget disease of the nipple 49
mammary pagets disease 10
pagets disease mammary 45
paget cell neoplasm 8
osteitis deformans 61
paget's disease 8


External Ids:

Disease Ontology8 DOID:3443
NCIt40 C7073
MESH via Orphanet36 D010144
ICD10 via Orphanet26 C50.0
SNOMED-CT via Orphanet58 2985005, 403946000
UMLS via Orphanet62 C0030185, C1704323
ICD1025 M88.9

Related Diseases for Mammary Paget's Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mammary Paget's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1paget's disease of bone30.8BGLAP, CALCA
2osteitis fibrosa30.3BGLAP
3osteoporosis30.2BGLAP, CALCA, TNFRSF11A, TNFSF11, TNFRSF11B, CFTR
4angioid streaks10.3
5iritis10.2
6hemifacial spasm10.2
7cancer progression/metastasis10.2
8paget disease, extramammary10.2
9hepatitis10.0KRT8
10hepatitis b10.0KRT8
11cervical cancer10.0KRT14
12mixed cell type cancer10.0KRT7
13endometriosis10.0PGR
14meningioma10.0PGR
15root resorption10.0TNFRSF11B
16primary hyperoxaluria10.0TNFRSF11B
17renal oncocytoma10.0KRT7
18kidney cancer10.0KRT7
19papilloma10.0LALBA, KRT14
20anorexia nervosa10.0TNFRSF11B
21periodontitis10.0TNFRSF11B
22craniopharyngioma10.0KRT8, KRT14
23obesity10.0AR
24psoriasis10.0KRT14, KRT18
25angiomyolipoma10.0PGR
26pancreatitis10.0CFTR
27viral hepatitis10.0KRT8, KRT18
28cystadenoma10.0KRT7
29gastritis10.0KRT18
30polycystic ovary syndrome10.0AR
31cirrhosis, noncryptogenic10.0KRT18, KRT8
32thyroiditis10.0CALCA
33leukoplakia10.0KRT8
34hepatoblastoma10.0KRT7, KRT18
35hemochromatosis10.0CFTR
36secretory meningioma10.0KRT7
37sinusitis10.0CFTR
38thymic carcinoma10.0KRT18, KRT7
39li-fraumeni syndrome10.0ERBB2, PGR
40skin cancer10.0KRT18, KRT8
41adenosarcoma10.0PGR
42sarcoma10.0KRT8, AR
43angiosarcoma10.0KRT18, KRT14, KRT8
44leukemia10.0KRT14, CFTR
45cryptorchidism10.0AR
46neuroendocrine tumor10.0CALCA
47hypertension10.0CALCA
48gingivitis10.0TNFRSF11B, TNFSF11
49osteosclerosis10.0TNFSF11, TNFRSF11B
50arthropathy10.0TNFSF11, TNFRSF11B

Graphical network of the top 20 diseases related to Mammary Paget's Disease:



Diseases related to mammary paget's disease

Clinical Features for Mammary Paget's Disease

Drugs & Therapeutics for Mammary Paget's Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Mammary Paget's Disease

Drug clinical trials:

Search ClinicalTrials for Mammary Paget's Disease

Search NIH Clinical Center for Mammary Paget's Disease

Search CenterWatch for Mammary Paget's Disease

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Mammary Paget's Disease

Anatomical Context for Mammary Paget's Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Mammary Paget's Disease:

33
Skin, Breast

Animal Models for Mammary Paget's Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Mammary Paget's Disease

Sources:
51PubMed
See all sources

Articles related to Mammary Paget's Disease:

(show all 24)
idTitleAuthorsYear
1
Superficial sebaceous carcinoma on the areola clinically mimicking mammary Paget's disease. (23078184)
2013
2
Characteristics of mammary Paget's disease in China: a national-wide multicenter retrospective study during 1999-2008. (22901142)
2012
3
Keratin Expression in Mammary Paget's Disease in situ with Intraductal Invasion. (23525171)
2012
4
Cystic fibrosis transmembrane conductance regulator is helpful in the distinction of extra-mammary Paget's disease from squamous cell carcinoma in situ (Bowen's disease). (21352263)
2011
5
Effectiveness of photodynamic therapy for mammary and extra-mammary Paget's disease: a state of the science review. (21676258)
2011
6
Mammary Paget's disease and extra-mammary Paget's disease: two morphologically similar but biologically different diseases. (19719834)
2010
7
Different panels of markers should be used to predict mammary Paget's disease associated with in situ or invasive ductal carcinoma of the breast. (19201736)
2009
8
Extra-mammary Paget's disease of the scrotum and penis: a case report. (20184077)
2009
9
Pigmented spots as a sign of mammary Paget's disease. (18627392)
2009
10
Mammary and extramammary Paget's disease: an immunohistochemical study of 83 cases. (17448019)
2007
11
Cytokeratin 7 staining was useful in a case of pigmented mammary Paget's disease resembling malignant melanoma. (17040462)
2006
12
Treatment of mammary and extramammary Paget's skin disease with topical imiquimod. (16854759)
2006
13
Assessment of Her-2/Neu status by immunohistochemistry and fluorescence in situ hybridization in mammary Paget disease and underlying carcinoma. (12777994)
2003
14
Morphological evidence for field effect as a mechanism for tumour spread in mammary Paget's disease. (10583581)
1999
15
Mammary Paget's disease: evidence of diverse origin of the disease with a subgroup of Paget's disease developing from the superficial portion of lactiferous duct and a discontinuous pattern of tumor spread. (10594841)
1999
16
Cytokeratin 7 staining in mammary and extramammary Paget's disease. (9388055)
1997
17
A comparative immunohistochemical study of mammary and extramammary Paget's disease and superficial spreading melanoma, with particular emphasis on melanocytic markers. (8982382)
1996
18
Immunohistochemical study of mammary and extramammary Paget's disease. (7763023)
1995
19
Adenocarcinoma of the mammary-like glands of the vulva: a concept unifying sweat gland carcinoma of the vulva, carcinoma of supernumerary mammary glands and extramammary Paget's disease. (8040464)
1994
20
Mammary Paget's disease and associated carcinoma. An immunohistochemical study. (7680194)
1993
21
Stump the experts. Extra-mammary Paget's disease in the perianal region. (2157742)
1990
22
c-erbB-2 oncoprotein expression in mammary and extramammary Paget's disease: an immunohistochemical study. (2173676)
1990
23
Study of neu-protein expression in mammary Paget's disease with and without underlying breast carcinoma and in extramammary Paget's disease. (1701961)
1990
24
Immunohistochemical study of mammary and extra-mammary Paget's disease. (6098546)
1984

Genetic Variations for Mammary Paget's Disease

Expression for genes affiliated with Mammary Paget's Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mammary Paget's Disease

Search GEO for disease gene expression data for Mammary Paget's Disease.

Pathways for genes affiliated with Mammary Paget's Disease

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 52QIAGEN, 4Cell Signaling Technology
See all sources

Pathways related to Mammary Paget's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TNFRSF11B, TNFSF11
2
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Hide members
9.8TNFRSF11A, TNFSF11, SQSTM1
39.8TNFRSF11B, TNFSF11, TNFRSF11A
49.5SQSTM1, TNFRSF11B, TNFSF11, TNFRSF11A
5
Hide members
9.5TNFRSF11A, TNFSF11, TNFRSF11B, SQSTM1
69.4KRT18, KRT14, KRT7, KRT8
79.3VCP, KRT8, KRT7, KRT18
8
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
8.3AR, TNFRSF11B, TNFSF11, TNFRSF11A, CALCA, BGLAP

Compounds for genes affiliated with Mammary Paget's Disease

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Mammary Paget's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6LALBA
2clodronate45 50 1112.0TNFRSF11B, TNFSF11, CALCA
3polyethylene4510.0TNFRSF11A, TNFSF11, TNFRSF11B
4fulvestrant45 50 29 1112.9AR, PGR, KRT18, ERBB2
5denosumab45 1110.9CALCA, TNFRSF11A, TNFSF11, TNFRSF11B
6forskolin45 50 1111.8CALCA, KRT18, KRT8
7hematoxylin459.4KRT8, KRT7, KRT14, KRT18
8exemestane50 45 60 1112.3BGLAP, AR, PGR, ERBB2
9etidronate459.3BGLAP, CALCA, TNFRSF11B
10nandrolone decanoate45 1110.3BGLAP, CALCA, AR
11teriparatide45 1110.2BGLAP, CALCA, TNFSF11, TNFRSF11B
12ibandronate45 1110.2BGLAP, CALCA, TNFSF11, TNFRSF11B
13retinoid459.2AR, PGR, KRT18, KRT14, KRT7, KRT8
14anastrozole45 1110.2ERBB2, PGR, BGLAP
15vitamin k2459.2BGLAP, CALCA, TNFSF11, TNFRSF11B
16pamidronate45 50 1111.2BGLAP, CALCA, TNFSF11, TNFRSF11B
17risedronate45 60 50 29 1113.2BGLAP, CALCA, TNFSF11, TNFRSF11B
18zoledronic acid459.1BGLAP, CALCA, TNFSF11, TNFRSF11B
19deoxypyridinoline459.1BGLAP, CALCA, TNFSF11, TNFRSF11B
20urea45 11 2411.1CSN3, TNFSF11, TNFRSF11B, KRT18, KRT14, KRT8
21alendronate45 50 1111.1TNFRSF11B, TNFSF11, CALCA, BGLAP
22genistein45 29 60 2 11 2414.1TNFSF11, TNFRSF11B, AR, PGR, CFTR, KRT8
23lactose45 1110.1CSN3, CFTR, KRT7, LALBA
2425-hydroxyvitamin d459.1BGLAP, CALCA, TNFSF11, TNFRSF11B
25phosphorus459.1TNFRSF11B, TNFSF11, CALCA, BGLAP
26steroid459.1TNFSF11, TNFRSF11B, AR, KRT18, KRT8, LALBA
27cysteine459.1LALBA, KRT8, KRT14, CFTR, PGR, TNFSF11
28iron45 2410.0CSN3, KRT18, KRT14, KRT7, KRT8, LALBA
29doxorubicin45 50 1111.0TNFSF11, TNFRSF11B, AR, PGR, CFTR, KRT18
30hydrocortisone45 2 60 1112.0BGLAP, CALCA, TNFRSF11B, KRT14, ERBB2
31tartrate459.0BGLAP, CALCA, TNFSF11
32hydroxyapatite459.0BGLAP, CSN3, TNFRSF11A, TNFSF11, TNFRSF11B
331,25 dihydroxy vitamin d3458.9BGLAP, CALCA, TNFRSF11A, TNFSF11, TNFRSF11B
34dexamethasone45 50 29 1111.8BGLAP, TNFSF11, TNFRSF11B, AR, CFTR, KRT18
35tamoxifen45 50 29 1111.7BGLAP, TNFRSF11B, AR, PGR, KRT14, KRT8
36calcitriol45 60 11 2411.7BGLAP, CALCA, TNFRSF11A, TNFSF11, TNFRSF11B, AR
37ascorbic acid45 249.7BGLAP, TNFSF11, TNFRSF11B, AR, CFTR, KRT18
38raloxifene45 29 50 1111.6BGLAP, CALCA, TNFRSF11A, TNFSF11, TNFRSF11B, PGR
39progesterone45 60 29 11 2412.5TNFRSF11B, AR, PGR, KRT18, KRT14, KRT7
40serine458.3BGLAP, TNFRSF11A, TNFSF11, TNFRSF11B, SQSTM1, KRT14
41vitamin d458.3BGLAP, CALCA, TNFSF11, TNFRSF11B, AR, CFTR
42aspartate458.2BGLAP, TNFRSF11B, AR, PGR, CFTR, KRT18
43cyclosporin a45 29 6010.0BGLAP, CALCA, TNFSF11, TNFRSF11B, PGR, CFTR
44lipid458.0TNFRSF11A, TNFSF11, TNFRSF11B, PCYT1A, KRT18, KRT14
45paraffin457.7BGLAP, TNFSF11, AR, PGR, CFTR, KRT18
46tyrosine457.6TNFRSF11A, TNFSF11, TNFRSF11B, SQSTM1, TRIP6, KRT18
47retinoic acid45 248.5BGLAP, TNFRSF11B, AR, PCYT1A, PGR, CFTR
48vegf457.4TNFSF11, TNFRSF11A, CALCA, BGLAP, TNFRSF11B, AR
49testosterone45 60 11 2410.3TNFRSF11B, TNFSF11, CALCA, BGLAP, AR, PGR
50calcium45 50 11 249.8BGLAP, CALCA, CSN3, TNFRSF11A, TNFSF11, TNFRSF11B

GO Terms for genes affiliated with Mammary Paget's Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Mammary Paget's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.4KRT8, KRT7, KRT14, KRT18
2keratin filamentGO:0450959.1KRT8, KRT7, KRT14, KRT18

Biological processes related to Mammary Paget's Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.2TNFRSF11A, TNFSF11
2TNFSF11-mediated signaling pathwayGO:07184710.2TNFRSF11A, TNFSF11
3positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.1TNFRSF11A, TNFSF11
4tertiary branching involved in mammary gland duct morphogenesisGO:06074810.0PGR, AR
5mammary gland alveolus developmentGO:06074910.0AR, TNFSF11, TNFRSF11A
6monocyte chemotaxisGO:0025489.9CALCA, TNFRSF11A, TNFSF11
7positive regulation of transcription from RNA polymerase III promoterGO:0459459.9AR, ERBB2
8tumor necrosis factor-mediated signaling pathwayGO:0332099.9KRT8, KRT18, TNFSF11, TNFRSF11A
9negative regulation of bone resorptionGO:0457799.6TNFRSF11B, CALCA
10cell-cell signalingGO:0072679.3LALBA, PGR, AR, TNFRSF11A, CALCA
11response to estrogen stimulusGO:0436279.1CFTR, TNFRSF11B, BGLAP
12signal transductionGO:0071658.9ERBB2, LALBA, PGR, AR, TNFRSF11B, TNFRSF11A

Molecular functions related to Mammary Paget's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051988.5KRT8, KRT7, KRT18, BGLAP
2protein bindingGO:0055157.0PGR, TRIP6, AR, SQSTM1, TNFRSF11A, CFTR

Products for genes affiliated with Mammary Paget's Disease

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  • Proteins
  • Lysates
  • Antibodies

Sources for Mammary Paget's Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet