MCID: MMM001
MIFTS: 56

Mammary Paget's Disease malady

Reproductive diseases, Cancer diseases categories

Summaries for Mammary Paget's Disease

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32MalaCards
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MalaCards: Mammary Paget's Disease, also known as paget's disease of the nipple, is related to paget's disease of bone and paget disease, juvenile. An important gene associated with Mammary Paget's Disease is KRT14 (keratin 14), and among its related pathways are Osteoblast Signaling and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drugs calcitonin and salmon calcitonin and the compounds estrogen and clodronate have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and skin, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Mammary Paget's Disease

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

mammary paget's disease 8 42
paget's disease of the nipple 42 48
paget's disease, mammary 42 60
paget's disease of the breast 8
paget disease of the breast 42
paget disease of the nipple 48
mammary pagets disease 10
pagets disease mammary 44
paget cell neoplasm 8
osteitis deformans 60
paget's disease 8


External Ids:

Disease Ontology8 DOID:3443
NCIt39 C7073
MESH via Orphanet35 D010144
ICD10 via Orphanet26 C50.0
SNOMED-CT via Orphanet57 2985005, 403946000
UMLS via Orphanet61 C0030185, C1704323
ICD1025 M88.9

Related Diseases for Mammary Paget's Disease

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17GeneCards, 18GeneDecks
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Diseases related to Mammary Paget's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1paget's disease of bone31.0BGLAP, CALCA
2paget disease, juvenile30.6CALCA, TNFRSF11A, TNFSF11, TNFRSF11B
3osteosclerosis30.2TNFSF11, TNFRSF11B
4osteitis fibrosa30.2BGLAP
5osteoporosis30.2BGLAP, CALCA, TNFRSF11A, TNFSF11, TNFRSF11B, CFTR
6prostate cancer30.2BGLAP, TNFRSF11A, TNFSF11, TNFRSF11B, SQSTM1, AR
7breast disease10.3
8angioid streaks10.3
9iritis10.2
10prostate disease10.2
11prostatitis10.2
12retinitis10.2
13in situ carcinoma10.1
14paget disease, extramammary10.1
15hepatitis10.0KRT8
16hepatitis b10.0KRT8
17cervical cancer10.0KRT14
18mixed cell type cancer10.0KRT7
19endometriosis10.0PGR
20meningioma10.0PGR
21root resorption10.0TNFRSF11B
22primary hyperoxaluria10.0TNFRSF11B
23renal oncocytoma10.0KRT7
24kidney cancer10.0KRT7
25papilloma10.0LALBA, KRT14
26anorexia nervosa10.0TNFRSF11B
27craniopharyngioma10.0KRT8, KRT14
28periodontitis10.0TNFRSF11B
29obesity10.0AR
30psoriasis10.0KRT14, KRT18
31angiomyolipoma10.0PGR
32pancreatitis10.0CFTR
33viral hepatitis10.0KRT8, KRT18
34cystadenoma10.0KRT7
35gastritis10.0KRT18
36polycystic ovary syndrome10.0AR
37cirrhosis, noncryptogenic10.0KRT18, KRT8
38thyroiditis10.0CALCA
39leukoplakia10.0KRT8
40hepatoblastoma10.0KRT7, KRT18
41secretory meningioma10.0KRT7
42hemochromatosis10.0CFTR
43sinusitis10.0CFTR
44thymus cancer10.0KRT18, KRT7
45li-fraumeni syndrome10.0ERBB2, PGR
46adenosarcoma10.0PGR
47sarcoma10.0KRT8, AR
48angiosarcoma10.0KRT18, KRT14, KRT8
49cryptorchidism10.0AR
50leukemia10.0KRT14, CFTR

Graphical network of the top 20 diseases related to Mammary Paget's Disease:



Diseases related to mammary paget's disease

Clinical Features for Mammary Paget's Disease

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Drugs & Therapeutics for Mammary Paget's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mammary Paget's Disease

Drug clinical trials:

Search ClinicalTrials for Mammary Paget's Disease

Search NIH Clinical Center for Mammary Paget's Disease

Search CenterWatch for Mammary Paget's Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Mammary Paget's Disease

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Anatomical Context for Mammary Paget's Disease

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32MalaCards
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MalaCards organs/tissues related to Mammary Paget's Disease:

32
Breast, Bone, Skin

Animal Models for Mammary Paget's Disease or affiliated genes

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Sources:
36MGI
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Publications for Mammary Paget's Disease

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50PubMed
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Articles related to Mammary Paget's Disease:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
A rare presentation of mammary Paget's disease involving the entire breast in the absence of any underlying ductal malignancy. (23760322)
2013
2
An Unusual Case of Mammary Paget's Disease Diagnosed Using Dynamic Contrast-Enhanced MRI. (23607031)
2013
3
Pigmented mammary Paget's disease mimicking melanoma: report of three cases. (22064040)
2012
4
Characteristics of mammary Paget's disease in China: a national-wide multicenter retrospective study during 1999-2008. (22901142)
2012
5
Keratin Expression in Mammary Paget's Disease in situ with Intraductal Invasion. (23525171)
2012
6
Cystic fibrosis transmembrane conductance regulator is helpful in the distinction of extra-mammary Paget's disease from squamous cell carcinoma in situ (Bowen's disease). (21352263)
2011
7
Extra-mammary Paget's disease of the perianal region: a review of the literature emphasizing the operative management technique. (20884199)
2011
8
A case report of pigmented mammary Paget's disease mimicking nevus of the nipple. (21213079)
2011
9
Effectiveness of photodynamic therapy for mammary and extra-mammary Paget's disease: a state of the science review. (21676258)
2011
10
Mammary Paget's disease and extra-mammary Paget's disease: two morphologically similar but biologically different diseases. (19719834)
2010
11
Different panels of markers should be used to predict mammary Paget's disease associated with in situ or invasive ductal carcinoma of the breast. (19201736)
2009
12
Pigmented mammary Paget's disease presenting as an enlarged areola. (19601948)
2009
13
Extra-mammary Paget's disease of the scrotum and penis: a case report. (20184077)
2009
14
Pigmented mammary Paget's disease: not a melanoma. (19413640)
2009
15
Pigmented mammary Paget's disease mimicking melanoma a further case in a man. (19470138)
2009
16
Pigmented spots as a sign of mammary Paget's disease. (18627392)
2009
17
Allergic contact dermatitis mimicking mammary paget's disease. (19882019)
2008
18
Acinar pattern of mammary Paget's disease: a case report. (17760678)
2007
19
Quadruple extra-mammary Paget's disease. (17225023)
2007
20
Extensive mammary Paget's disease. (17397359)
2007
21
Mammary and extramammary Paget's disease: an immunohistochemical study of 83 cases. (17448019)
2007
22
Pigmented mammary Paget's disease. (17567331)
2007
23
Clinical and histopathologic observations of the action of imiquimod in an epithelioid hemangioendothelioma and Paget's mammary disease. (16781296)
2006
24
Mammary Paget's disease occurring after mastectomy. (16899115)
2006
25
Cytokeratin 7 staining was useful in a case of pigmented mammary Paget's disease resembling malignant melanoma. (17040462)
2006
26
Treatment of mammary and extramammary Paget's skin disease with topical imiquimod. (16854759)
2006
27
Androgen receptors are frequently expressed in mammary and extramammary Paget's disease. (15920545)
2005
28
Pigmented mammary Paget's disease mimicking melanoma. (15057051)
2004
29
The ectopic expression of gastric mucin in extramammary and mammary Paget's disease. (11979091)
2002
30
Differential expression of mucin genes in mammary and extramammary Paget's disease. (11717535)
2001
31
Mammary and extramammary Paget's disease. (11064666)
2000
32
Mammary Paget's disease: evidence of diverse origin of the disease with a subgroup of Paget's disease developing from the superficial portion of lactiferous duct and a discontinuous pattern of tumor spread. (10594841)
1999
33
Mammary Paget's disease with acantholytic features and without any detectable breast tumor. (10089077)
1998
34
Cytokeratin 7 staining in mammary and extramammary Paget's disease. (9388055)
1997
35
Expression of desmogleins in Paget cells of mammary and extramammary Paget's disease. (9339649)
1997
36
A comparative immunohistochemical study of mammary and extramammary Paget's disease and superficial spreading melanoma, with particular emphasis on melanocytic markers. (8982382)
1996
37
Human papilloma virus DNA: a factor in the pathogenesis of mammary Paget's disease? (8932876)
1996
38
Mammary Paget's disease confined to the areola and associated with multifocal Toker cell hyperplasia. (8599455)
1995
39
Immunohistochemical study of mammary and extramammary Paget's disease. (7763023)
1995
40
Adenocarcinoma of the mammary-like glands of the vulva: a concept unifying sweat gland carcinoma of the vulva, carcinoma of supernumerary mammary glands and extramammary Paget's disease. (8040464)
1994
41
A case of mammary Paget's disease without an underlying carcinoma: microscopic analysis of the DNA content in Paget cells. (8014269)
1994
42
Mammary Paget's disease and associated carcinoma. An immunohistochemical study. (7680194)
1993
43
Study of neu-protein expression in mammary Paget's disease with and without underlying breast carcinoma and in extramammary Paget's disease. (1701961)
1990
44
Extra-mammary Paget's disease of the penis. (2537673)
1989
45
Mucin-negative biopsy in extra-mammary Paget's disease. A diagnostic problem. (2478441)
1989
46
Mammary Paget's disease without underlying carcinoma. (3026196)
1985
47
Immunohistochemical study of mammary and extra-mammary Paget's disease. (6098546)
1984
48
MAMMARY PAGET'S DISEASE. (14179983)
1964
49
Extra-mammary Paget's disease; discussion of pathogenesis. (14892969)
1952
50
Findings in a case of extra-mammary Paget's disease. (14783970)
1950

Genetic Variations for Mammary Paget's Disease

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Expression for genes affiliated with Mammary Paget's Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mammary Paget's Disease

Search GEO for disease gene expression data for Mammary Paget's Disease.

Pathways for genes affiliated with Mammary Paget's Disease

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Mammary Paget's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TNFRSF11B, TNFSF11
2
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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9.8TNFRSF11A, TNFSF11, SQSTM1
39.8TNFRSF11B, TNFSF11, TNFRSF11A
49.5SQSTM1, TNFRSF11B, TNFSF11, TNFRSF11A
5
Hide members
9.5TNFRSF11A, TNFSF11, TNFRSF11B, SQSTM1
69.4KRT18, KRT14, KRT7, KRT8
79.3VCP, KRT8, KRT7, KRT18
8
Transcription Role of VDR in regulation of genes involved in osteoporosis
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8.3AR, TNFRSF11B, TNFSF11, TNFRSF11A, CALCA, BGLAP

Compounds for genes affiliated with Mammary Paget's Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Mammary Paget's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6LALBA
2clodronate44 49 1112.0CALCA, TNFSF11, TNFRSF11B
3polyethylene4410.0TNFSF11, TNFRSF11A, TNFRSF11B
4fulvestrant44 49 28 1112.9AR, PGR, KRT18, ERBB2
5denosumab44 1110.9CALCA, TNFRSF11B, TNFSF11, TNFRSF11A
6forskolin44 49 1111.8CALCA, KRT18, KRT8
7hematoxylin449.4KRT7, KRT14, KRT8, KRT18
8exemestane49 44 59 1112.3BGLAP, ERBB2, PGR, AR
9etidronate449.3CALCA, BGLAP, TNFRSF11B
10nandrolone decanoate44 1110.3BGLAP, AR, CALCA
11teriparatide44 1110.2TNFRSF11B, TNFSF11, CALCA, BGLAP
12ibandronate44 1110.2TNFRSF11B, TNFSF11, CALCA, BGLAP
13retinoid449.2KRT7, KRT8, AR, PGR, KRT18, KRT14
14anastrozole44 1110.2BGLAP, PGR, ERBB2
15vitamin k2449.2TNFRSF11B, BGLAP, CALCA, TNFSF11
16pamidronate44 49 1111.2TNFSF11, BGLAP, CALCA, TNFRSF11B
17risedronate44 59 49 28 1113.2CALCA, TNFSF11, TNFRSF11B, BGLAP
18zoledronic acid449.1BGLAP, TNFRSF11B, TNFSF11, CALCA
19deoxypyridinoline449.1BGLAP, CALCA, TNFRSF11B, TNFSF11
20urea44 11 2411.1TNFRSF11B, TNFSF11, KRT18, KRT14, KRT8, LALBA
21alendronate44 49 1111.1CALCA, TNFSF11, TNFRSF11B, BGLAP
22genistein44 28 59 2 11 2414.1AR, ERBB2, KRT8, CFTR, PGR, TNFSF11
23lactose44 1110.1LALBA, CSN3, CFTR, KRT7
2425-hydroxyvitamin d449.1TNFRSF11B, CALCA, BGLAP, TNFSF11
25phosphorus449.1TNFRSF11B, TNFSF11, BGLAP, CALCA
26steroid449.1TNFSF11, TNFRSF11B, AR, KRT18, LALBA, ERBB2
27cysteine449.1KRT14, CFTR, PGR, TNFSF11, KRT8, LALBA
28iron44 2410.0KRT18, KRT14, KRT7, KRT8, LALBA, CSN3
29doxorubicin44 49 1111.0KRT18, KRT8, TNFRSF11B, TNFSF11, CFTR, PGR
30hydrocortisone44 2 59 1112.0TNFRSF11B, ERBB2, CALCA, BGLAP, KRT14
31tartrate449.0BGLAP, CALCA, TNFSF11
32hydroxyapatite449.0TNFSF11, CSN3, TNFRSF11B, BGLAP, TNFRSF11A
331,25 dihydroxy vitamin d3448.9CALCA, BGLAP, TNFRSF11A, TNFRSF11B, TNFSF11
34dexamethasone44 49 28 1111.8CFTR, TNFRSF11B, KRT18, AR, BGLAP, TNFSF11
35tamoxifen44 49 28 1111.7PGR, BGLAP, TNFRSF11B, AR, ERBB2, KRT8
36calcitriol44 59 11 2411.7CALCA, BGLAP, TNFRSF11A, TNFSF11, TNFRSF11B, AR
37ascorbic acid44 249.7TNFSF11, TNFRSF11B, AR, KRT18, BGLAP, CFTR
38raloxifene44 28 49 1111.6TNFSF11, TNFRSF11A, PGR, TNFRSF11B, ERBB2, CALCA
39progesterone44 59 28 11 2412.5KRT8, KRT7, TNFRSF11B, LALBA, KRT14, ERBB2
40serine448.3KRT14, VCP, ERBB2, KRT8, SQSTM1, TNFRSF11B
41vitamin d448.3TNFSF11, TNFRSF11B, AR, CFTR, KRT14, ERBB2
42aspartate448.2CFTR, BGLAP, TNFRSF11B, AR, LALBA, PGR
43cyclosporin a44 28 5910.0PGR, BGLAP, CALCA, TNFSF11, TNFRSF11B, CFTR
44lipid448.0TNFRSF11B, KRT8, KRT7, LALBA, KRT14, VCP
45paraffin447.7CFTR, AR, ERBB2, KRT8, KRT14, KRT18
46tyrosine447.6KRT14, VCP, ERBB2, LALBA, KRT8, KRT18
47retinoic acid44 248.5KRT8, TNFRSF11B, PCYT1A, PGR, BGLAP, AR
48vegf447.4KRT18, AR, KRT8, KRT7, PGR, TNFRSF11B
49testosterone44 59 11 2410.3ERBB2, KRT7, KRT18, PGR, AR, BGLAP
50calcium44 49 11 249.8LALBA, KRT8, KRT14, CDH7, TNFSF11, TNFRSF11A

GO Terms for genes affiliated with Mammary Paget's Disease

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16Gene Ontology
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Cellular components related to Mammary Paget's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.4KRT8, KRT7, KRT14, KRT18
2keratin filamentGO:0450959.1KRT8, KRT7, KRT14, KRT18

Biological processes related to Mammary Paget's Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.2TNFRSF11A, TNFSF11
2TNFSF11-mediated signaling pathwayGO:07184710.2TNFRSF11A, TNFSF11
3positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.1TNFRSF11A, TNFSF11
4tertiary branching involved in mammary gland duct morphogenesisGO:06074810.0PGR, AR
5mammary gland alveolus developmentGO:06074910.0AR, TNFSF11, TNFRSF11A
6monocyte chemotaxisGO:0025489.9CALCA, TNFRSF11A, TNFSF11
7positive regulation of transcription from RNA polymerase III promoterGO:0459459.9AR, ERBB2
8tumor necrosis factor-mediated signaling pathwayGO:0332099.9KRT8, KRT18, TNFSF11, TNFRSF11A
9negative regulation of bone resorptionGO:0457799.6TNFRSF11B, CALCA
10cell-cell signalingGO:0072679.3LALBA, PGR, AR, TNFRSF11A, CALCA
11response to estrogen stimulusGO:0436279.1CFTR, TNFRSF11B, BGLAP
12signal transductionGO:0071658.9ERBB2, LALBA, PGR, AR, TNFRSF11B, TNFRSF11A

Molecular functions related to Mammary Paget's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051988.5KRT8, KRT7, KRT18, BGLAP
2protein bindingGO:0055157.0PGR, TRIP6, AR, SQSTM1, TNFRSF11A, CFTR

Products for genes affiliated with Mammary Paget's Disease

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  • Antibodies
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Sources for Mammary Paget's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet