Manic-depressive Illness malady

Wikipedia: Bipolar disorder or bipolar affective disorder (historically known as manic-depressive disorder) is a...⁴⁴ more...

MalaCards: Manic-depressive Illness, also known as bipolar disorder, is related to bipolar disorder and schizophrenia. An important gene associated with Manic-depressive Illness is INPP1 (inositol polyphosphate-1-phosphatase), and among its related pathways are Amine Oxidase reactions and Translation Non-genomic (rapid) action of Androgen Receptor. The drugs divalproex and topiramate and the compounds tyramine and choline have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are endocrine/exocrine gland and skeleton.

manic-depressive illness 7 bipolar disorder 43

Diseases related to manic-depressive illness by text searches and GeneDecks gene sharing:

(show top 50)    (show all 156)

id	Related Disease	Score	Top Affiliating Genes
1	bipolar disorder	39.9	GSK3B, SLC6A4, GABRB1
2	schizophrenia	30.1	MAOA, DRD2, DRD3
3	bipolar i disorder	29.7	DRD2, TH, SLC6A4
4	major affective disorder	29.5	DRD2, TH, SLC6A4
5	schizoaffective disorder	28.6	MAOA, TPH1, DRD2, DRD3, DRD4, SLC6A4
6	ppm-x syndrome	28.0	MAOB, DRD2, DRD4, SLC6A3, SLC6A4
7	major depressive disorder	28.0	GSK3B, MC2R, MAOA, MAOB, TPH1, DRD2
8	panic disorder	27.2	MAOA, TPH1, DRD2, DRD3, DRD4, SLC6A4
9	alcoholism	26.2	MAOA, MAOB, TPH1, DRD2, DRD3, DRD4
10	intellectual disability	25.7	MED12, MAOA, HRAS, DRD4, SLC6A3, SLC6A4
11	twinning	25.4	GSK3B, MAOA, DRD2, DRD4, G6PD, TH
12	seizures	25.3	MAOA, MAOB, TH, SLC6A3, SLC6A4, GABRB1
13	mood disorder	25.3	MAOA, MAOB, TPH1, DRD2, DRD3, DRD4
14	neuronitis	24.4	GSK3B, MED12, MC2R, MAOA, MAOB, MARCKS
15	bipolar affective disorder	23.9	MAOA, MAOB, TPH1, DRD2, DRD3, DRD4
16	cerebritis	22.0	MAOA, MAOB, MARCKS, TPH1, DRD2, DRD3
17	cholesterol	21.4	GSK3B, MED12, MC2R, MAOB, HRAS, DRD2
18	neuroblastoma	21.3	GSK3B, MAOA, MAOB, MARCKS, HRAS, DRD2
19	alzheimer's disease	21.0	GSK3B, MAOA, MAOB, MARCKS, HRAS, TPH1
20	pure autonomic failure	13.3	TH, DBH
21	delusional disorder	13.2	DRD3, DRD4, TH
22	orthostatic hypotension	13.1	MAOA, MAOB, DBH
23	phenylketonuria	13.1	TPH1, G6PD, TH
24	hyperphenylalaninemia	13.1	TPH1, G6PD, TH
25	opiate dependence	13.1	DRD2, DRD3
26	tic disorder	13.1	DRD2, DRD4
27	conduct disorder	13.0	MAOA, SLC6A4
28	endogenous depression	13.0	DRD3, SLC6A4
29	myoclonus-dystonia	13.0	DRD2, DRD3, DRD4
30	seasonal affective disorder	12.9	TPH1, DRD4, SLC6A4
31	post-traumatic stress disorder	12.9	MAOA, DRD2, DBH
32	generalized anxiety disorder	12.9	MAOA, TPH1, SLC6A4
33	novelty seeking personality	12.9	MAOA, DRD2, DRD4
34	small intestine adenocarcinoma	12.9	MARCKS, HRAS, CTNNB1
35	melancholia	12.9	MAOA, SLC6A4
36	borderline personality disorder	12.9	MAOA, TPH1, SLC6A4
37	carcinoid syndrome	12.8	MAOA, TPH1, TH, DBH
38	attention deficit hyperactivity disorder	12.8	DRD4, SLC6A3
39	separation anxiety disorder	12.8	DRD4, SLC6A3
40	autistic disorder	12.8	TH, DBH, SLC6A4
41	hepatic encephalopathy	12.7	MAOA, MAOB, DRD2
42	bulimia nervosa	12.7	MAOA, TPH1, DRD4, SLC6A4
43	carcinoid tumors	12.7	TPH1, CTNNB1, TH, DBH
44	hyperprolactinemia	12.6	DRD2, DRD4, TH, DBH
45	hypothyroidism	12.6	MED12, MC2R, G6PD, DBH
46	syncope	12.6	G6PD, DBH, SLC6A4
47	constipation	12.6	MED12, TH, DBH, SLC6A4
48	dihydropteridine reductase deficiency	12.6	TH, SLC6A3
49	social phobia	12.6	MAOA, DRD2, SLC6A4
50	alcohol withdrawal delirium	12.6	TH, DBH, SLC6A3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carbamazepine, clonazepam, clozapine, divalproex, divalproex sodium, gabapentin, gabapentin enacarbil, lamotrigine, lithium, lithium (as citrate), lithium carbonate, lithium citrate, olanzapine, quetiapine, quetiapine fumarate, risperidone, tiagabine, tiagabine hydrochloride, topiramate, valproate sodium, valproic acid

MalaCards organs/tissues related to manic-depressive illness:

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MGI Mouse Phenotypes related to manic-depressive illness:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.7	DBH, MC2R
2	skeleton phenotype	MP:0005390	8.6	MED12, CTNNB1, MARCKS, HRAS, DRD2
3	no phenotypic analysis	MP:0003012	7.7	HRAS, DRD2, INPP1, CTNNB1, TH, GABRA3
4	integument phenotype	MP:0010771	6.7	SLC6A4, DRD2, CTNNB1, TH, DBH, SLC6A3
5	cardiovascular system phenotype	MP:0005385	6.6	MED12, DRD3, G6PD, CTNNB1, DBH, DRD2
6	growth/size phenotype	MP:0005378	5.8	GSK3B, HRAS, TPH1, DRD2, DRD3, MARCKS
7	mortality/aging	MP:0010768	5.5	GSK3B, DBH, SLC6A3, SLC6A4, G6PD, CTNNB1
8	nervous system phenotype	MP:0003631	5.2	MAOA, DRD2, MED12, MAOB, MARCKS, HRAS
9	behavior/neurological phenotype	MP:0005386	4.7	CTNNB1, DRD2, GSK3B, HRAS, TPH1, DRD3
10	homeostasis/metabolism phenotype	MP:0005376	4.6	SLC6A4, DRD3, DRD2, TPH1, HRAS, MAOB

Articles related to manic-depressive illness:

(show all 21)

id	Title	Authors	Year	Affiliating Genes
1	Association analysis of the HOPA12bp polymorphism in schizophrenia and manic depressive illness. (12627458)	Kirov G.... Owen M.J.	2003	MED12
2	Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes. (11901356)	Piccardi M.P.... Del Zompo M.	2002	SLC6A4, INPP1
3	Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness. (10826666)	Manji H.K.... Chen G.	2000	CTNNB1
4	Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challenge. (10518159)	Ikonomov O.C.... Manji H.K.	1999	GSK3B
5	Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illness. (10622182)	Manji H.K.... Lenox R.H.	1999	MARCKS
6	Association between the tryptophan hydroxylase gene and manic-depressive illness. (9435758)	Bellivier F.... Malafosse A.	1998	TPH1
7	The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic- depressive illness. (9682271)	Steen V.M.... Gulbrandsen A.K.	1998	INPP1
8	Genetic association between monoamine oxidase and manic-depressive illness: comparison of relative risk and haplotype relative risk data. (9342194)	Parsian A.... Todd R.D.	1997	MAOA, MAOB
9	A study of genetic association between manic-depressive illness and a highly polymorphic marker from the GABRbeta-1 gene. (9184321)	Puertollano R.... Fernandez-Piqueras J.	1997	GABRB1
10	Manic depressive illness and tyrosine hydroxylase gene: linkage heterogeneity and association. (9440122)	Malafosse A.... Mallet J.	1997	TH
11	No association between particular DRD3 and DAT gene polymorphisms and manic-depressive illness in a Spanish sample. (9149327)	Gomez-Casero E.... Fernandez-Piqueras J.	1996	SLC6A3, DRD3
12	Lack of association between manic-depressive illness and a highly polymorphic marker from GABRA3 gene. (8546157)	Puertollano R.... Fernandez-Piqueras J.	1995	GABRA3
13	Manic-depressive illness and linkage reanalysis in the Xq27-Xq28 region of chromosome X. (7760986)	Mendelbaum K.... Mendlewicz J.	1995	G6PD
14	No evidence of linkage between manic depressive illness and the dopa decarboxylase gene or nearby region on chromosome 7p. (8750358)	Ewald H.... Kruse T.A.	1995	TH, DBH
15	Lithium and the brain: a psychopharmacological strategy to a molecular basis for manic depressive illness. (8313612)	Lenox R.H.... Watson D.G.	1994	MARCKS
16	Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. (8016089)	Berrettini W.H.... Gershon E.S.	1994	MC2R
17	No association between dopamine D4 receptor polymorphism and manic depressive illness. (7853381)	PAcrez de Castro I.... Llinares C.	1994	DRD4
18	Linkage analysis between manic depressive illness and the dopamine beta-hydroxylase gene. (7719704)	Ewald H.... Kruse T.A.	1994	DBH
19	Exclusion of linkage between manic depressive illness and tyrosine hydroxylase and dopamine D2 receptor genes. (7914141)	Ewald H.... Kruse T.	1994	TH, DRD2
20	Absence of linkage between chromosome 11p15 markers and manic-depressive illness in a Belgian pedigree. (1683520)	Mendlewicz J.... Mallet J.	1991	HRAS
21	X-chromosome markers and manic-depressive illness. Rejection of linkage to Xq28 in nine bipolar pedigrees. (2322087)	Berrettini W.H.... Detera-Wadleigh S.	1990	G6PD

Genes related to manic-depressive illness according to GeneCards:

(show all 20)

id	Symbol	Description	Score	GeneCards Section Context
1	INPP1	inositol polyphosphate-1-phosphatase	11.0	Publications
2	MARCKS	myristoylated alanine-rich protein kinase C substrate	11.0	Publications
3	MC2R	melanocortin 2 receptor (adrenocorticotropic hormone)	11.0	Publications
4	MED12	mediator complex subunit 12	11.0	Publications
5	TPH1	tryptophan hydroxylase 1	11.0	Publications
6	DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	11.0	Publications
7	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
8	MAOA	monoamine oxidase A	11.0	Publications
9	MAOB	monoamine oxidase B	11.0	Publications
10	DRD3	dopamine receptor D3	11.0	Publications
11	TH	tyrosine hydroxylase	11.0	Publications
12	DRD4	dopamine receptor D4	11.0	Publications
13	GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	11.0	Publications
14	GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	11.0	Publications
15	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0	Publications
16	GSK3B	glycogen synthase kinase 3 beta	11.0	Publications
17	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications
18	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
19	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
20	DRD2	dopamine receptor D2	11.0	Publications

Pathways related to manic-depressive illness according to GeneDecks:

(show all 29)

id	Pathway	Score	Top Affiliating Genes
1	Amine Oxidase reactions38	10.3	MAOB, MAOA
2	Translation Non-genomic (rapid) action of Androgen Receptor10	10.2	CTNNB1
3	Tryptophan metabolism20	10.1	MAOA, TPH1, MAOB
4	Tyrosine metabolism p.1 (dopamine)10	9.8	MAOA, MAOB, TH, DBH
5	Tyrosine metabolism p.1 (dopamine)41	9.8	MAOA, MAOB, TH, DBH
6	Tyrosine metabolism20	9.8	MAOA, TH, MAOB, DBH
7	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	9.7	MAOA, TPH1, SLC6A4
8	Amine ligand-binding receptors38	9.7	DRD2, DRD4, DRD3
9	Development_HGF signaling pathway41	9.4	CTNNB1, GSK3B, HRAS
10	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics34	9.4	DRD4, TH, DRD3, DRD2
11	Endometrial cancer20	9.4	CTNNB1, HRAS, GSK3B
12	Signal transduction_PTEN pathway41	9.4	CTNNB1, GSK3B, HRAS
13	Signal transduction PTEN pathway10	9.4	CTNNB1, HRAS, GSK3B
14	Development A2B receptor- action via G-protein alpha s10	9.4	CTNNB1, HRAS, GSK3B
15	Development_A2B receptor- action via G-protein alpha s41	9.4	CTNNB1, HRAS, GSK3B
16	Translation_Non-genomic (rapid) action of Androgen Receptor41	9.3	HRAS, GSK3B, CTNNB1
17	Development Endothelin-1/EDNRA signaling10	9.3	GSK3B, HRAS, CTNNB1
18	Development_Endothelin-1/EDNRA signaling41	9.3	GSK3B, HRAS, CTNNB1
19	Development A3 receptor signaling10	9.3	GSK3B, CTNNB1, HRAS
20	Cytoskeleton remodeling Integrin outside-in signaling10	9.2	HRAS, GSK3B, CTNNB1
21	Transcription_Androgen Receptor nuclear signaling41	9.2	GSK3B, HRAS, CTNNB1
22	Development_A3 receptor signaling41	9.2	HRAS, GSK3B, CTNNB1
23	Cytoskeleton remodeling_Integrin outside-in signaling41	9.1	GSK3B, HRAS, CTNNB1
24	Cytoskeleton remodeling_Reverse signaling by ephrin B41	9.1	CTNNB1, GSK3B, HRAS
25	Metabolic pathways20	9.0	TH, INPP1, MAOA, MAOB, TPH1, G6PD
26	Transcription Androgen Receptor nuclear signaling10	9.0	CTNNB1, HRAS, GSK3B
27	Neuroactive ligand-receptor interaction20	8.8	DRD4, GABRA3, GABRB1, MC2R, DRD2, DRD3
28	Cytoskeleton remodeling Reverse signaling by ephrin B10	8.8	CTNNB1, HRAS, GSK3B
29	CDK5 Pathway36	8.8	DRD3, DRD4, HRAS, CTNNB1, DRD2

Compounds related to manic-depressive illness according to GeneDecks:

(show top 50)    (show all 215)

id	Compound	Score	Top Affiliating Genes
1	tyramine32 18	11.3	TH, MAOB
2	choline32 9 18 9	13.3	TPH1, MAOB
3	dopac32	9.5	MAOA, MAOB, DRD3, DBH, TH
4	benzamide32	9.2	DRD3, DRD4, MAOA, DRD2
5	nomifensine32 9 9	11.1	MAOA, SLC6A3, TH, MAOB
6	carbidopa32	9.0	TPH1, MAOB, TH, DBH, SLC6A3
7	homovanillic acid32 18	10.0	MAOA, TPH1, MAOB, DBH, SLC6A4, TH
8	rotigotine32 9 9	11.0	DRD3, DRD2, MAOB, DRD4
9	alpha-methyl-p-tyrosine32	8.9	DRD2, TH, DBH, SLC6A3
10	mhpg32	8.9	DRD4, SLC6A4, MAOB, MAOA, TH, DBH
11	p-chloroamphetamine32	8.8	SLC6A4, SLC6A3, MAOB, MAOA
12	catecholamine32	8.8	MAOB, MARCKS, DBH, TH, DRD3, MAOA
13	mazindol32 9 9	10.8	SLC6A3, TH, MAOB, SLC6A4
14	glutamate32	8.7	MARCKS, TH, MAOA, CTNNB1, DRD4, DRD2
15	cysteine32	8.7	CTNNB1, TH, TPH1, HRAS, MAOB, DBH
16	phentermine32 9 9	10.7	MAOA, MAOB, SLC6A3, SLC6A4
17	MMDA9 9	9.7	SLC6A4, MAOA, MAOB, SLC6A3
18	4-Methoxyamphetamine9 9	9.7	MAOA, MAOB, SLC6A4, SLC6A3
19	amine32	8.6	MAOB, TPH1, MAOA, DBH, DRD3, SLC6A4
20	pramipexole32 9 9	10.6	SLC6A3, TH, DRD3, DRD2, DRD4
21	1 methyl 4 phenylpyridinium32	8.5	SLC6A4, SLC6A3, TH, MAOB, MAOA
22	lithium32 34 9 18 9	12.4	DBH, CTNNB1, SLC6A4, TPH1, MARCKS, GSK3B
23	mdma32	8.4	SLC6A3, MAOA, MAOB, TPH1, SLC6A4, TH
24	paroxetine32 34 9 9	11.3	MAOA, SLC6A4, SLC6A3, DRD4, TPH1
25	apomorphine32 9 9	10.3	SLC6A3, MAOB, DRD2, DRD3, TH, DRD4
26	imipramine32 34 9 18 9	12.3	MAOA, MAOB, DRD3, DBH, SLC6A3, SLC6A4
27	quetiapine32 9 18 9	11.2	DRD3, DRD2, DRD4, TH, SLC6A3
28	bupropion32 34 9 18 9	12.2	SLC6A3, SLC6A4, DRD3, MAOB, DRD2
29	heroin32 9 9	10.2	SLC6A4, DRD4, DRD3, DRD2, SLC6A3
30	fluoxetine32 34 9 9	11.1	MAOA, SLC6A4, DRD2, SLC6A3, TPH1, MAOB
31	d amphetamine32	8.1	SLC6A3, DRD2, TH, SLC6A4, MAOB, MAOA
32	epinephrine32 9 18 9	11.0	MAOB, DRD2, MAOA, DRD4, G6PD, TH
33	opiate32	8.0	TH, SLC6A4, SLC6A3, DBH, DRD2, DRD3
34	6-hydroxydopamine32	7.9	MAOA, MAOB, DRD2, DRD4, DRD3, TH
35	methylphenidate32 9 9	9.8	TH, MAOB, MAOA, SLC6A3, DRD4, SLC6A4
36	levodopa32 9 9	9.7	TPH1, MAOB, DRD3, MAOA, DRD2, SLC6A3
37	risperidone32 34 9 18 9	11.6	DRD2, DRD3, SLC6A3, SLC6A4, DRD4
38	mptp32	7.6	MAOA, MAOB, DRD3, DRD2, TH, DBH
39	amphetamine32 9 9	9.6	MAOA, DRD2, TPH1, MAOB, DRD4, TH
40	cocaine32 9 9	9.5	DRD2, DRD3, TH, DBH, SLC6A3, SLC6A4
41	clozapine32 34 9 9	10.5	CTNNB1, TH, SLC6A3, DRD4, SLC6A4, DRD2
42	maoa32	7.4	SLC6A4, MAOA, MAOB, TPH1, DRD2, DRD4
43	5-hydroxytryptamine32	7.3	MAOB, MAOA, TPH1, DRD2, TH, SLC6A4
44	methamphetamine32 9 9	9.3	SLC6A4, DRD2, SLC6A3, TH, DRD4, MAOA
45	haloperidol32 34 9 9	10.2	CTNNB1, DRD3, SLC6A3, DRD2, MAOB, SLC6A4
46	gaba32 42	8.0	MAOA, MAOB, TPH1, DRD2, DBH, GABRB1
47	h2o232	6.9	CTNNB1, TPH1, MAOA, G6PD, TH, SLC6A3
48	norepinephrine32 9 18 9	9.9	MARCKS, TPH1, DRD2, DRD3, TH, DBH
49	nmda32 42	7.7	TH, SLC6A3, SLC6A4, CTNNB1, MAOA, MAOB
50	dopamine32 9 18 9	9.5	SLC6A4, CTNNB1, TH, DBH, DRD2, TPH1

Cellular components related to manic-depressive illness according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Axin-APC-beta-catenin-GSK3B complex	GO:034747	9.4	CTNNB1, GSK3B
2	apical part of cell	GO:045177	9.1	DRD3, CTNNB1, DBH
3	neuronal cell body	GO:043025	8.6	GSK3B, DRD4, DBH, SLC6A3
4	integral to plasma membrane	GO:005887	7.0	DRD3, MC2R, DRD2, DRD4, SLC6A3, SLC6A4
5	plasma membrane	GO:005886	5.4	GSK3B, GABRB1, GABRA3, SLC6A4, MC2R, MARCKS

Biological processes related to manic-depressive illness according to GeneDecks:

(show all 43)

id	Name	GO ID	Score	Top Affiliating Genes
1	norepinephrine biosynthetic process	GO:042421	10.3	DBH, TH
2	fear response	GO:042596	10.2	DRD4, DBH
3	catecholamine biosynthetic process	GO:042423	10.2	DBH, TH
4	negative regulation of dopamine receptor signaling pathway	GO:060160	10.0	DRD2, DRD3
5	regulation of cAMP metabolic process	GO:030814	10.0	DRD3, DRD2
6	regulation of dopamine uptake involved in synaptic transmission	GO:051584	10.0	DRD2, DRD3
7	positive regulation of dopamine uptake involved in synaptic transmission	GO:051586	10.0	DRD2, DRD4
8	regulation of dopamine secretion	GO:014059	9.8	DRD3, DRD2
9	behavioral response to ethanol	GO:048149	9.8	DRD4, DBH, DRD2
10	G-protein coupled receptor internalization	GO:002031	9.8	DRD2, DRD3
11	response to histamine	GO:034776	9.8	DRD3, DRD4, DRD2
12	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO:007195	9.8	DRD2, DRD4, DRD3
13	behavioral response to cocaine	GO:048148	9.8	DRD4, DRD3, DRD2
14	dopamine metabolic process	GO:042417	9.7	DRD4, DRD3, DRD2
15	negative regulation of protein secretion	GO:050709	9.7	DRD2, DRD3, DRD4
16	arachidonic acid secretion	GO:050482	9.7	DRD2, DRD3, DRD4
17	regulation of synaptic transmission, GABAergic	GO:032228	9.7	HRAS, DRD2
18	negative regulation of adenylate cyclase activity	GO:007194	9.7	DRD3, DRD2, DRD4
19	memory	GO:007613	9.6	DBH, SLC6A4, TH
20	dopamine catabolic process	GO:042420	9.6	DBH, SLC6A3, MAOA
21	regulation of dopamine metabolic process	GO:042053	9.6	SLC6A3, DRD4
22	dopamine biosynthetic process	GO:042416	9.6	TH, SLC6A3
23	circadian regulation of gene expression	GO:032922	9.6	DRD3, DRD2
24	response to amphetamine	GO:001975	9.5	DRD3, DRD4, DBH, DRD2
25	neurotransmitter biosynthetic process	GO:042136	9.5	SLC6A3, TH, MAOA
26	synaptic transmission, dopaminergic	GO:001963	9.5	DRD2, DRD3, DRD4, TH
27	visual learning	GO:008542	9.4	DRD3, HRAS, DRD2, DBH
28	adenohypophysis development	GO:021984	9.4	DRD2, SLC6A3
29	negative regulation of oligodendrocyte differentiation	GO:048715	9.4	DRD3, CTNNB1
30	organ morphogenesis	GO:009887	9.3	GSK3B, TH, HRAS
31	monoamine transport	GO:015844	9.3	SLC6A4, SLC6A3
32	response to iron ion	GO:010039	9.3	DRD2, DBH, SLC6A3
33	response to toxin	GO:009636	9.3	MAOB, SLC6A4, DRD2
34	prepulse inhibition	GO:060134	9.2	DRD3, DRD2, SLC6A3
35	response to cocaine	GO:042220	9.2	SLC6A3, DRD3, DRD2
36	response to ethanol	GO:045471	9.2	MAOB, TH, DRD3, SLC6A3
37	response to estradiol stimulus	GO:032355	9.1	DBH, SLC6A4, CTNNB1
38	social behavior	GO:035176	9.0	DRD3, SLC6A4, DBH, DRD4, HRAS
39	small molecule metabolic process	GO:044281	8.8	DBH, TH, G6PD, TPH1, MARCKS, MAOB
40	locomotory behavior	GO:007626	8.7	DRD3, DRD2, TH, DBH, SLC6A3
41	synaptic transmission	GO:007268	8.4	GABRA3, MAOA, SLC6A3, HRAS, DBH, GABRB1
42	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.4	DRD2, MED12, CTNNB1, GSK3B, HRAS, DRD3
43	response to drug	GO:042493	7.4	SLC6A3, MAOB, DRD3, GSK3B, SLC6A4, CTNNB1

Molecular functions related to manic-depressive illness according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	primary amine oxidase activity	GO:008131	10.0	MAOB, MAOA
2	dopamine receptor activity, coupled via Gi/Go	GO:001591	9.4	DRD2, DRD3, DRD4
3	ionotropic glutamate receptor binding	GO:035255	9.0	DRD2, GSK3B, CTNNB1
4	monoamine transmembrane transporter activity	GO:008504	8.7	SLC6A4, SLC6A3
5	dopamine binding	GO:035240	8.6	SLC6A3, DRD4, DRD3, DRD2
6	drug binding	GO:008144	8.4	SLC6A3, DRD4, DRD3, DRD2