Mannose-binding Protein Deficiency malady

Genetics Home Reference: Mannose-binding lectin deficiency is a condition that affects the immune system. People with this condition have low levels of an immune system protein called mannose-binding lectin in their blood. These individuals are prone to recurrent infections, including infections of the upper respiratory tract and other body systems. People with this condition may also contract more serious infections such as pneumonia and meningitis. Depending on the type of infection, the symptoms caused by the infections vary in frequency and severity.¹⁷

MalaCards: Mannose-binding Protein Deficiency, also known as mannose-binding lectin deficiency, is related to protein-energy malnutrition and cryptosporidiosis. An important gene associated with Mannose-binding Protein Deficiency is MBL2 (mannose-binding lectin (protein C) 2, soluble).

Wikipedia: Mannose-binding lectin (MBL), also called mannose-binding protein or mannan-binding protein (MBP), is a...⁴⁴ more...

mannose-binding protein deficiency 16 33 43 mannose-binding lectin deficiency 16 17 mbl2 deficiency 16 17

mbp deficiency 16 17 mbl deficiency 17 malnutrition 43

Diseases related to mannose-binding protein deficiency by text searches and GeneDecks gene sharing:

(show top 50)    (show all 324)

id	Related Disease	Score	Top Affiliating Genes
1	protein-energy malnutrition	8.9
2	cryptosporidiosis	8.4
3	protein s deficiency	8.1
4	peritonitis	7.5
5	invasive aspergillosis	7.5
6	juvenile rheumatoid arthritis	7.5
7	leukemia	7.5
8	liver cirrhosis	7.5
9	lymphoblastic leukemia	7.5
10	acute pyelonephritis	7.5
11	pyelonephritis	7.5
12	acute lymphoblastic leukemia	7.5
13	rheumatoid arthritis	7.5
14	arthritis	7.5
15	sepsis	7.5
16	aspergillosis	7.5
17	septic shock	7.5
18	atherosclerosis	7.5
19	cryptococcosis	7.5
20	cystic fibrosis	7.5
21	cytomegalovirus infection	7.5
22	fibrosis	7.5
23	influenza	7.5
24	hepatitis	7.2
25	lupus erythematosus	7.2
26	malaria	7.2
27	systemic lupus erythematosus	7.2
28	tuberculosis	7.2
29	hepatitis b	7.2
30	chronic infections, due to mbl deficiency	6.5
31	alcoholism	6.3
32	anemia	6.0
33	anorexia nervosa	6.0
34	pancreatitis	6.0
35	carcinoma	5.6
36	diarrhea	5.6
37	rickets	5.6
38	uremia	5.6
39	cystic fibrosis lung disease	5.6
40	pulmonary disease	5.1
41	ancylostomiasis	5.1
42	chronic obstructive pulmonary disease	5.1
43	hyperhomocysteinemia	5.1
44	immunodeficiency	5.1
45	kwashiorkor	5.1
46	marasmus	5.1
47	nutritional deficiency disease	5.1
48	overnutrition	5.1
49	fabry disease	4.2
50	glucose transporter type 1 deficiency syndrome	4.2

Approved drugs:

Drug clinical trials:

Genetic tests related to mannose-binding protein deficiency:

id	Genetic test	Affiliating Genes
1	Mannose-binding Protein Deficiency clinical/research	MBL2

Articles related to mannose-binding protein deficiency:

id	Title	Authors	Year	Affiliating Genes
1	Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. (9519208)	Bellamy R.... Hill A.V.	1998	MBL2
2	Frequency of mannose-binding protein deficiency in patients with systemic lupus erythematosus. (7488298)	Senaldi G.... Reid K.B.	1995	MBL2

Genes related to mannose-binding protein deficiency according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	MBL2	mannose-binding lectin (protein C) 2, soluble	11.1	Publications, Disorders