MCID: MNT001
MIFTS: 63

Mantle Cell Lymphoma malady

Rare diseases, Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Mantle Cell Lymphoma

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NIH Rare Diseases:43 Mantle cell lymphoma (mcl) belongs to a group of diseases known as  non-hodgkin’s lymphomas (nhl), which are cancers that affect the the lymphatic system (part of the immune system). mcl accounts for 6% of all non-hodgkin lymphomas and is mostly found in males during their early 60s. lymphocytes, which are white blood cells that make up the lymphatic system. there are two main types: b-lymphocytes (b-cells) and t-lymphocytes (t-cells). mantel cell lymphoma is a b-cell lymphoma that develops from cancerous b-cells within a region of the lymph node known as the mantle zone. although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time. last updated: 7/20/2011

MalaCards based summary: Mantle Cell Lymphoma, also known as lcm, is related to leukemia and chronic lymphocytic leukemia, and has symptoms including lymphadenopathy, hematological neoplasm and splenomegaly. An important gene associated with Mantle Cell Lymphoma is CCND1 (cyclin D1), and among its related pathways are TP53 network and FOXM1 transcription factor network. The compounds okadaic acid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lymph node, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:10 A b-cell lymphocytic neoplasm due to cd5 positive antigen-naive pregerminal center b-cell within the mantle zone that surrounds normal germinal center follicles.

Wikipedia:65 Mantle cell lymphoma (MCL) is a type of non-Hodgkin\'s lymphoma (NHL), comprising about 6% of NHL cases.... more...

Aliases & Classifications for Mantle Cell Lymphoma

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Sources:
32LifeMap Discovery®, 10Disease Ontology, 43NIH Rare Diseases, 12DISEASES, 45Novoseek, 49Orphanet, 24GTR, 62UMLS, 36MESH via Orphanet, 28ICD10 via Orphanet, 27ICD10
See all sources

Mantle Cell Lymphoma, Aliases & Descriptions:

Name: Mantle Cell Lymphoma 32 10 43 12 49
Lcm 43 49 62
Mantle Zone Lymphoma 43 49
Lymphoma Mantle-Cell 45 24
 
Mcl 43 49
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse 62
Malignant Lymphoma - Lymphocytic, Intermediate Differentiation 62
Lymphoma, Mantle Cell 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

49
mantle cell lymphoma:
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (United States),1-9/100000 (Europe),1-9/100000 (France); Age of onset: Adult; Age of death: adult


External Ids:

Disease Ontology10 DOID:0050746
Orphanet49 52416
MESH via Orphanet36 D020522
ICD10 via Orphanet28 C83.1
ICD1027 C83.1

Related Diseases for Mantle Cell Lymphoma

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Diseases related to Mantle Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.3CCND1, IGH, PRAME, ATM, CD5, CD52
2chronic lymphocytic leukemia31.2IGH, CD5, CCND1, IGHM, ATM
3b-cell lymphomas31.2IGHM, CD5, CCND1, IGH, ATM, CCND2
4hodgkin lymphoma31.2IGHM, CCND2, IGH, ATM
5myeloma30.8IGH, IGHM, CCND2, CCND1
6multiple myeloma30.8CKS1B, CCND1, CCND2
7macroglobulinemia30.7CD5
8malt lymphoma30.7CD5, CCND1, IGHM, IGH
9follicular lymphoma30.7CD5, CCND1, IGHM, IGH
10prolymphocytic leukemia30.7CD5, CCND1, ATM
11waldenstrom macroglobulinemia30.4IGHM, IGH, CCND1
12acute leukemia30.3ATM, IGH, PRAME
13adenoma30.3CCND2, CCND1, ATM, CKS1B
14diffuse large b-cell lymphoma10.7
15marginal zone b-cell lymphoma10.5
16prostatitis10.5
17splenomegaly10.5
18hematopoietic stem cell transplantation10.5
19glomerulonephritis10.4
20splenic marginal zone lymphoma10.4
21composite lymphoma10.4
22endotheliitis10.4
23gastrointestinal stromal tumor10.3
24ataxia-telangiectasia10.3
25peripheral t-cell lymphoma10.3
26thrombocytopenia10.3
27membranoproliferative glomerulonephritis10.3
28leukostasis10.3
29adenocarcinoma10.3
30interstitial nephritis10.3
31pancreatitis10.3
32ataxia10.3
33nephritis10.3
34glomus tumor10.3
35wells syndrome10.3
36prostate cancer10.2
37retinoblastoma10.2
38renal cell carcinoma10.2
39anaplastic large cell lymphoma10.2
40focal segmental glomerulosclerosis10.2
41hepatitis10.2
42liver cirrhosis10.2
43lymphoblastic lymphoma10.2
44myasthenia gravis10.2
45myelofibrosis10.2
46neutropenia10.2
47pulmonary tuberculosis10.2
48polyclonal hypergammaglobulinemia10.2
49appendicitis10.2
50intussusception10.2

Graphical network of the top 20 diseases related to Mantle Cell Lymphoma:



Diseases related to mantle cell lymphoma

Symptoms for Mantle Cell Lymphoma

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Symptoms:

 49 (show all 7)
  • lymphadenopathy/polyadenopathies
  • hematologic/blood/lymphatic cancer
  • splenomegaly
  • anorexia
  • bone marrow/medullar infiltration
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness

HPO human phenotypes related to Mantle Cell Lymphoma:

id Description Frequency HPO Source Accession
1 lymphadenopathy hallmark (90%) HP:0002716
2 hematological neoplasm hallmark (90%) HP:0004377
3 splenomegaly typical (50%) HP:0001744
4 weight loss typical (50%) HP:0001824
5 anorexia typical (50%) HP:0002039

Drugs & Therapeutics for Mantle Cell Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Mantle Cell Lymphoma

Search NIH Clinical Center for Mantle Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Mantle Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Mantle Cell Lymphoma

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Genetic tests related to Mantle Cell Lymphoma:

id Genetic test Affiliating Genes
1 Mantle Cell Lymphoma24

Anatomical Context for Mantle Cell Lymphoma

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MalaCards organs/tissues related to Mantle Cell Lymphoma:

33
B cells, T cells, Lymph node, Bone, Bone marrow, Colon, Prostate, Monocytes, Skin, Endothelial, Testis, Brain, Small intestine, Kidney, Liver, Adrenal gland, Breast, Testes, Myeloid, Trachea, Appendix

Animal Models for Mantle Cell Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Mantle Cell Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5CKS1B, CCND1, PMAIP1, IGHM, ATM
2MP:00053978.5CCND2, CKS1B, CCND1, SOX11, PMAIP1, IGL
3MP:00053878.3CD5, ATM, CKS1B, CCND2, CCND1, SOX11

Publications for Mantle Cell Lymphoma

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Articles related to Mantle Cell Lymphoma:

(show top 50)    (show all 864)
idTitleAuthorsYear
1
Ibrutinib approved for mantle cell lymphoma. (24402946)
2014
2
Ibrutinib: a strong candidate for the future of mantle cell lymphoma treatment. (23730878)
2013
3
Long-term follow-up of lenalidomide in relapsed/refractory mantle cell lymphoma: subset analysis of the NHL-003 study. (24030098)
2013
4
Molecular characterization of chromosomal band 5p15.33: a recurrent breakpoint region in mantle cell lymphoma involving the TERT-CLPTM1L locus. (23137523)
2013
5
MicroRNAs in mantle cell lymphoma. (23339447)
2013
6
Egress of CD19(+)CD5(+) cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients. (23940282)
2013
7
A key role for EZH2 in epigenetic silencing of HOX genes in mantle cell lymphoma. (24107828)
2013
8
Retrospective analysis of 235 unselected patients with mantle cell lymphoma confirms prognostic relevance of Mantle Cell Lymphoma International Prognostic Index and Ki-67 in the era of rituximab: long-term data from the Czech Lymphoma Project Database. (23772666)
2013
9
Current and emerging therapies in mantle cell lymphoma. (23512567)
2013
10
Mantle cell lymphoma presenting as a pelvi-ureteric junction obstruction: a case report. (23590763)
2013
11
Combined effect of histone deacetylase inhibitor suberoylanilide hydroxamic acid and anti-CD20 monoclonal antibody rituximab on mantle cell lymphoma cells apoptosis. (22475365)
2012
12
Relapsed and/or Refractory Mantle Cell Lymphoma: What Role for Temsirolimus? (22550404)
2012
13
NVP-BEZ235 alone and in combination in mantle cell lymphoma: an effective therapeutic strategy. (22920938)
2012
14
FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: is FTY720 the next autophagy-blocking agent in lymphoma treatment? (22377620)
2012
15
Scoring systems in mantle cell lymphoma: a critical point of view. (21915995)
2012
16
A retrospective study evaluating the efficacy and safety of bendamustine in the treatment of mantle cell lymphoma. (22185662)
2012
17
Treatment of patients with refractory diffuse large B-cell lymphoma or mantle cell lymphoma with alemtuzumab, alone or in combination with cytotoxic chemotherapy. (21067447)
2011
18
Chlorambucil in indolent mantle cell lymphoma--just another old drug for a new disease? (21271863)
2011
19
Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo. (21750224)
2011
20
Prognostic relevance of clinical risk factors in mantle cell lymphoma. (21782060)
2011
21
Patterns and outcome of relapse after autologous stem cell transplantation for mantle cell lymphoma. (21509767)
2011
22
Mantle cell lymphoma: recent insights into pathogenesis, clinical variability, and new diagnostic markers. (21850989)
2011
23
Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index. (21609366)
2011
24
Utility of positron emission tomography scans in mantle cell lymphoma. (21922524)
2011
25
Outcome of patients with mantle cell lymphoma is not influenced by vascular endothelial growth factor polymorphisms. (21067446)
2011
26
Identification of methylated genes associated with aggressive clinicopathological features in mantle cell lymphoma. (21603610)
2011
27
Treatment-induced oxidative stress and cellular antioxidant capacity determine response to bortezomib in mantle cell lymphoma. (21712452)
2011
28
Deregulated expression of the polycomb-group protein SUZ12 target genes characterizes mantle cell lymphoma. (20558579)
2010
29
Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells. (20647473)
2010
30
CD5-undetected by immunohistochemistry, t(11;14)(q13;q32)-positive conjunctival mantle cell lymphoma: a case report. (18572329)
2008
31
Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells. (17606765)
2007
32
Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. (17136116)
2007
33
Successful treatment of focal segmental glomerulosclerosis in association with mantle cell lymphoma. (17497453)
2007
34
Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma. (16461462)
2006
35
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. (16645163)
2006
36
Pathogenesis of mantle-cell lymphoma: all oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways. (16155021)
2005
37
Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma. (16337199)
2005
38
Biology and therapy of mantle cell lymphoma. (16093790)
2005
39
Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells. (16219581)
2005
40
Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. (16123218)
2005
41
Small lymphocytic lymphoma, marginal zone B-cell lymphoma, and mantle cell lymphoma exhibit distinct gene-expression profiles allowing molecular diagnosis. (14630827)
2004
42
Genetic and molecular genetic studies in the diagnosis of B-cell lymphomas I: mantle cell lymphoma, follicular lymphoma, and Burkitt's lymphoma. (12733111)
2003
43
PPP2R1B gene in chronic lymphocytic leukemias and mantle cell lymphomas. (11342371)
2001
44
Mantle cell lymphoma proliferates upon IL-10 in the CD40 system. (10942246)
2000
45
Multiparameter immunohistochemical analysis of the cell cycle proteins cyclin D1, Ki-67, p21WAF1, p27KIP1, and p53 in mantle cell lymphoma. (11035575)
2000
46
Mantle cell lymphoma, in leukaemic phase with prominent splenomegaly. A report of eight cases with similar clinical presentation and aggressive outcome. (11193469)
2000
47
Quantitative RNA slot-blot analysis of CCND1/cyclin D1 expression in suspected mantle cell lymphoma. (9436924)
1998
48
Expression of retinoblastoma gene product (pRb) in mantle cell lymphomas. Correlation with cyclin D1 (PRAD1/CCND1) mRNA levels and proliferative activity. (8623927)
1996
49
Detection of bcl-1 gene rearrangement and B-cell clonality in mantle cell lymphoma using formalin-fixed, paraffin-embedded tissues. (8526214)
1995
50
Efficacy of four different regimens in 64 mantle-cell lymphoma cases: clinicopathologic comparison with 498 other non-Hodgkin's lymphoma subtypes. European Organization for the Research and Treatment of Cancer Lymphoma Cooperative Group. (7595744)
1995

Variations for Mantle Cell Lymphoma

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Cosmic variations for Mantle Cell Lymphoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
122507ATMhaematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,mantle cell lymphoma1

Expression for genes affiliated with Mantle Cell Lymphoma

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Search GEO for disease gene expression data for Mantle Cell Lymphoma.

Pathways for genes affiliated with Mantle Cell Lymphoma

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Pathways related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1PMAIP1, ATM
210.0CKS1B, CCND1
310.0CCND1, CCND2
410.0CCND2, ATM
5
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.9IGH, IGHM, IGL
6
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.9IGH, IGHM, IGL
7
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.9IGL, IGHM, IGH
8
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.9IGL, IGHM, IGH
9
Show member pathways
Signaling Pathways in Glioblastoma38
9.9CCND2, CCND1, ATM
10
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.9ATM, CCND1, CCND2
11
Show member pathways
9.9CCND2, CCND1, ATM
12
Show member pathways
Cell cycle38
9.9CCND2, CCND1, ATM
139.9CCND2, CCND1, ATM
149.9ATM, CCND1, CCND2
159.9CCND2, CCND1, PMAIP1
169.8CD5, CCND2, IGHM
17
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.7CCND1, CCND2, CKS1B
18
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.7CKS1B, CCND2, CCND1
19
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
9.7ATM, PMAIP1, CCND1, CKS1B
20
Show member pathways
DNA damage response38
9.7CCND2, CCND1, PMAIP1, ATM
21
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.7CCND2, CCND1, PMAIP1, ATM
22
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.7IGH, IGL, CCND1, CCND2
23
Show member pathways
9.6ATM, CCND1, CCND2, CKS1B
24
Show member pathways
9.6ATM, CCND1, CCND2, CKS1B
25
Show member pathways
9.6ATM, CCND1, CCND2, CKS1B
26
Show member pathways
9.5ATM, PMAIP1, SOX11, CCND1, CCND2
279.4MIR29A, MIR17, MIR20A, MIR16-1, CCND1, ATM
289.1ATM, CCND1, CCND2, MIR16-1, MIR20A, MIR17

Compounds for genes affiliated with Mantle Cell Lymphoma

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Sources:
45Novoseek, 61Tocris Bioscience
See all sources

Compounds related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1okadaic acid45 6110.9CDK20, CCND1, ATM
2tyrosine458.8CD5, CDK20, CKS1B, CCND2, CCND1, ATM

GO Terms for genes affiliated with Mantle Cell Lymphoma

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Cellular components related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:000030710.0CCND2, CCND1

Biological processes related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:001016510.2CCND1, PMAIP1
2positive regulation of cyclin-dependent protein kinase activityGO:00457379.9CCND1, CCND2
3positive regulation of DNA damage response, signal transduction by p53 class mediatorGO:00435179.8PMAIP1, ATM
4cell divisionGO:00513019.4CDK20, CKS1B, CCND2, CCND1

Molecular functions related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase regulator activityGO:001653810.0CKS1B, CCND1

Products for genes affiliated with Mantle Cell Lymphoma

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Sources for Mantle Cell Lymphoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet