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LCM
MCID: MNT001
MIFTS: 63

Mantle Cell Lymphoma (LCM) malady

Cancer, Blood, Immune categories
7 symptoms, 237 genes, 21 tissues, 167 related diseases, clinical trials, genetic tests.

Summaries for Mantle Cell Lymphoma

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8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Mantle cell lymphoma (mcl) belongs to a group of diseases known as  non-hodgkin’s lymphomas (nhl), which are cancers that affect the the lymphatic system (part of the immune system). mcl accounts for 6% of all non-hodgkin lymphomas and is mostly found in males during their early 60s. lymphocytes, which are white blood cells that make up the lymphatic system. there are two main types: b-lymphocytes (b-cells) and t-lymphocytes (t-cells). mantel cell lymphoma is a b-cell lymphoma that develops from cancerous b-cells within a region of the lymph node known as the mantle zone. although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time. last updated: 7/20/2011

MalaCards: Mantle Cell Lymphoma, also known as lymphoma, mantle cell, is related to follicular lymphoma and b-cell lymphomas, and has symptoms including splenomegaly, asthenia/fatigue/weakness and weight loss/loss of appetite/break in weight curve/general health alteration. An important gene associated with Mantle Cell Lymphoma is ATM (ataxia telangiectasia mutated), and among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR. The compounds rapamycin and mimosine have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and kidney, and related mouse phenotypes are cellular and hematopoietic system.

Disease Ontology:8 A b-cell lymphocytic neoplasm due to cd5 positive antigen-naive pregerminal center b-cell within the mantle zone that surrounds normal germinal center follicles.

Wikipedia:64 Mantle cell lymphoma (MCL) is one of the rarest of the non-Hodgkin\'s lymphomas (NHLs), comprising about... more...

Aliases & Classifications for Mantle Cell Lymphoma

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8Disease Ontology, 43NIH Rare Diseases, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 31LifeMap Discovery™, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune
ICD10: 26 25


Characteristics (Orphanet epidemiological data):

49
mantle cell lymphoma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

mantle cell lymphoma 8 43 10 49 31
lymphoma, mantle cell 43 22 47
malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 61
malignant lymphoma - lymphocytic, intermediate differentiation 61
mucocutaneous lymph node syndrome 61
lymphocytic choriomeningitis 61
mantle zone lymphoma 49
lymphoma mantle-cell 45
lcm 49
mcl 49


External Ids:

Disease Ontology8 DOID:0050746
MESH via Orphanet36 D020522
ICD10 via Orphanet26 C83.1
SNOMED-CT via Orphanet58 443487006, 74654000
ICD1025 C83.1

Related Diseases for Mantle Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Mantle Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1follicular lymphoma31.0IGHM, CD5, IGH, CCND1
2b-cell lymphomas30.7CD5, IGHM, IGH, CCND2, CCND1, ATM
3b-cell chronic lymphocytic leukemia30.7CD5, CCND1, IGH, IGHM
4macroglobulinemia30.6CD5
5burkitt's lymphoma30.4CCNG1, IGH, SOX11, CCND2, IGHM
6acute leukemia30.4IGH, ATM, PRAME
7adenocarcinoma30.2CCND2, CCNG1, CCND1
8bone lymphoma10.7
9lymphoma, diffuse large cell10.6
10colon lymphoma10.6
11gastrointestinal lymphoma10.6
12composite lymphoma10.6
13indolent b cell lymphoma10.6
14t-cell leukemia10.5
15leukemia/lymphoma, t-cell10.5
16coronary aneurysm10.5
17splenomegaly10.5
18hepatitis c10.5
19hepatitis c virus10.5
20central nervous system lymphoma10.5
21gastric lymphoma10.5
22orbit lymphoma10.5
23splenic marginal zone lymphoma10.5
24leukemia, b-cell, chronic10.5
25lymphoma, somatic10.5
26growth hormone deficiency10.4
27adult syndrome10.4
28coronary artery aneurysm10.4
29periarteritis nodosa10.4
30cerebellar hypoplasia10.4
31prostate lymphoma10.4
32leukemia, t-cell, chronic10.4
33peripheral t-cell lymphoma10.4
34hematopoietic stem cell transplantation10.4
35stomatitis10.3
36lymphocytic choriomeningitis10.3
37membranoproliferative glomerulonephritis10.3
38ataxia telangiectasia10.3
39leukostasis10.3
40gastrointestinal stromal tumor10.3
41anaplastic large cell lymphoma10.3
42diffuse large b-cell lymphoma10.3
43squamous cell carcinoma10.3
44thrombocytopenia10.3
45castleman's disease10.3
46lymphoblastic lymphoma10.3
47ataxia10.3
48leukemia, chronic lymphocytic 110.3
49lymphoma/leukemia, b-cell, variant10.3
50nephritis10.3

Graphical network of the top 20 diseases related to Mantle Cell Lymphoma:



Diseases related to mantle cell lymphoma

Clinical Features for Mantle Cell Lymphoma

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49Orphanet
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Symptoms:

49 (show all 7)
  • splenomegaly
  • asthenia/fatigue/weakness
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • anorexia
  • lymphadenopathy/polyadenopathies
  • hematologic/blood/lymphatic cancer
  • bone marrow/medullar infiltration

Drugs & Therapeutics for Mantle Cell Lymphoma

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Mantle Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Mantle Cell Lymphoma

Search NIH Clinical Center for Mantle Cell Lymphoma

Search CenterWatch for Mantle Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Mantle Cell Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Mantle Cell Lymphoma:
Blood stem cell transplantation for hematological diseases
Hematopoietic stem cells for treatment of hematologic malignancies
Hematopoietic stem cells for treatment of non-Hodgkin's lymphoma
Peripheral blood stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Mantle Cell Lymphoma:
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived hematopoietic stem cells
Peripheral blood-derived hematopoietic stem cells, PMID: 21831743
Peripheral blood-derived hematopoietic stem cells (family)

Genetic Tests for Mantle Cell Lymphoma

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22GTR
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Genetic tests related to Mantle Cell Lymphoma:

id Genetic test Affiliating Genes
1 Mantle Cell Lymphoma22

Anatomical Context for Mantle Cell Lymphoma

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33MalaCards
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MalaCards organs/tissues related to Mantle Cell Lymphoma:

33
Skin, Brain, Kidney, Lymph node, Spleen, Bone marrow, Whole blood, Small intestine, Colon, Adrenal gland, Breast, Prostate, Testis, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Trachea, Appendix

Animal Models for Mantle Cell Lymphoma or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Mantle Cell Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
cellular phenotype
MP:000538411.1PMAIP1, CCND1, CCND2, CCNG1, SOX11, PIM2
2
hematopoietic system phenotype
MP:000539710.8PMAIP1, CCND1, CCND2, SOX11, PIM2, ATM

Publications for Mantle Cell Lymphoma

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51PubMed
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Articles related to Mantle Cell Lymphoma:

(show top 50)    (show all 840)
idTitleAuthorsYear
1
Autologous stem cell transplantation in mantle cell lymphoma: a report from the SFGM-TC. (23949376)
2014
2
Disseminated mantle-cell lymphoma presenting as a petechial maculopapular eruption. (24258452)
2014
3
Pharmacological and genomic profiling identifies NF-I_B-targeted treatment strategies for mantle cell lymphoma. (24362935)
2014
4
Unlocking new therapeutic targets and resistance mechanisms in mantle cell lymphoma. (24434205)
2014
5
Outcome of mantle cell lymphoma patients treated at a single institution over the past decade. (24338732)
2013
6
Immune evasion of mantle cell lymphoma: expression of B7-H1 leads to inhibited T-cell response to and killing of tumor cells. (23508008)
2013
7
Long-Term Follow-Up of R-CHOP With Bevacizumab as Initial Therapy for Mantle Cell Lymphoma: Clinical and Correlative Results. (24373788)
2013
8
Alkylating agents induce histone H3K18 hyperacetylation and potentiate HDAC inhibitor-mediated global histone acetylation and cytotoxicity in mantle cell lymphoma. (24335889)
2013
9
Risk factors of central nervous system relapse in mantle cell lymphoma. (23339449)
2013
10
SOXC transcription factors in mantle cell lymphoma: the role of promoter methylation in SOX11 expression. (23466598)
2013
11
Indolent mantle cell lymphoma. (23927395)
2013
12
Obinutuzumab (GA101) monotherapy in relapsed/refractory diffuse large b-cell lymphoma or mantle-cell lymphoma: results from the phase II GAUGUIN study. (23835718)
2013
13
Allogeneic hematopoietic cell transplantation for chemotherapy-unresponsive mantle cell lymphoma: a cohort analysis from the center for international blood and marrow transplant research. (23333532)
2013
14
ESMO Consensus conferences: guidelines on malignant lymphoma. part 2: marginal zone lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma. (23425945)
2013
15
The miRNA-17a8192 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. (22116552)
2012
16
Salvage treatment with lenalidomide and dexamethasone in relapsed/refractory mantle cell lymphoma: clinical results and effects on microenvironment and neo-angiogenic biomarkers. (22058200)
2012
17
Mantle cell lymphoma: a clinically heterogeneous disease in need of tailored approaches. (22710898)
2012
18
Pathologic Rupture of the Spleen in Mantle-Cell-Type Non-Hodgkin's Lymphoma. (22577390)
2012
19
Successful treatment of aortic rupture with endovascular stent grafting in a patient with mantle cell lymphoma. (22740816)
2012
20
Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis. (22490335)
2012
21
Chlorambucil in indolent mantle cell lymphoma--just another old drug for a new disease? (21271863)
2011
22
Prognostic relevance of clinical risk factors in mantle cell lymphoma. (21782060)
2011
23
Mantle cell lymphoma: report of the 2010 Mantle Cell Lymphoma Consortium Workshop. (21133727)
2011
24
Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling. (21394647)
2011
25
Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters. (21652541)
2011
26
Should there be a standard therapy for mantle cell lymphoma? (21345142)
2011
27
Mantle cell lymphoma: report of the 2009 Mantle Cell Lymphoma Consortium Workshop. (20038219)
2010
28
Temsirolimus in the treatment of relapsed or refractory mantle cell lymphoma. (20856791)
2010
29
Proteomic analysis of malignant B-cell derived microparticles reveals CD148 as a potentially useful antigenic biomarker for mantle cell lymphoma diagnosis. (19413345)
2009
30
Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value. (19594747)
2009
31
Specific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2. (18685613)
2008
32
Inactivation of RB1 in mantle-cell lymphoma detected by nonsense- mediated mRNA decay pathway inhibition and microarray analysis. (17332242)
2007
33
Evaluation of the MDR1, ABCG2, Topoisomerases IIalpha and GSTpi gene expression in patients affected by aggressive mantle cell lymphoma treated by the R-Hyper-CVAD regimen. (17701580)
2007
34
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. (16645163)
2006
35
Mantle cell lymphomas acquire increased expression of CCL4, CCL5 and 4-1BB-L implicated in cell survival. (16287062)
2006
36
High ZAP-70 expression correlates with worse clinical outcome in mantle cell lymphoma. (16932342)
2006
37
Targeting the proteasome in mantle cell lymphoma: a promising therapeutic approach. (16321849)
2006
38
H2AX is not affected in mantle cell lymphoma with 11q23 deletion. (16382446)
2006
39
PRAME is a membrane and cytoplasmic protein aberrantly expressed in chronic lymphocytic leukemia and mantle cell lymphoma. (16620968)
2006
40
Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells. (16219581)
2005
41
A model of in vivo purging with Rituximab and high-dose AraC in follicular and mantle cell lymphoma. (15170171)
2004
42
CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells. (14871974)
2004
43
CD52 expression in mantle cell lymphoma. (11999566)
2002
44
Proliferative response of mantle cell lymphoma cells stimulated by CD40 ligation and IL-4. (10673747)
2000
45
Development of intermediate-grade (mantle cell) and low-grade (small lymphocytic and marginal zone) human non-Hodgkin's lymphomas xenotransplanted in severe combined immunodeficiency mouse models. (10780672)
2000
46
Proliferative fraction, bcl-1 gene translocation, and p53 mutation status as markers in mantle cell lymphoma. (10085408)
1999
47
Expression of CD44 (HCAM) in small lymphocytic and mantle cell lymphoma. (9781654)
1998
48
Intranuclear expression of cyclin D1 protein as a useful prognostic marker for mantle cell lymphoma. (9640844)
1997
49
Detection of cyclin D1 (bcl-1, PRAD1) overexpression by a simple competitive reverse transcription-polymerase chain reaction assay in t(11;14)(q13;q32)-bearing B-cell malignancies and/or mantle cell lymphoma. (9028328)
1997
50
PRAD1 gene over-expression in mantle-cell lymphoma but not in other low-grade B-cell lymphomas, including extranodal lymphoma. (7918073)
1994

Genetic Variations for Mantle Cell Lymphoma

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Expression for genes affiliated with Mantle Cell Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mantle Cell Lymphoma

Search GEO for disease gene expression data for Mantle Cell Lymphoma.

Pathways for genes affiliated with Mantle Cell Lymphoma

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30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 12EMD Millipore
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Pathways related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
MicroRNAs in cancer30
11.1MIR17, MIR20A, CCNG1, CCND2, CCND1, MIR29A
2
miRNAs involved in DDR38
10.9CCND1, ATM, MIR20A, MIR29A, MIR16-1, MIR17
3
p53 signaling pathway30
Hide members
10.8CCNG1, CCND2, CCND1, PMAIP1, ATM
4
Wnt Signaling Pathway38
Hide members
10.8CCND2, ATM, PMAIP1, CCND1
5
GADD45 Pathway52
10.8ATM, CCND1, CCNG1, CCND2
6
Cyclins and Cell Cycle Regulation52
Hide members
10.7CCND1, ATM, CCND2
7
DNA damage ATM/ATR regulation of G1/S checkpoint12
10.7CCND1, ATM, CCND2
8
Cell cycle30
Hide members
10.7ATM, CCND1, CCND2
9
Mitotic G1-G1/S phases54
Hide members
10.7ATM, CCND2, CCND1
10
TP53 network38
10.6ATM, PMAIP1

Compounds for genes affiliated with Mantle Cell Lymphoma

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45Novoseek, 11DrugBank, 50PharmGKB
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Compounds related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rapamycin4510.7CCNG1, CCND1, CCND2, ATM
2mimosine45 1111.6CCNG1, CCND1
3doxorubicin45 50 1112.5ATM, CCND1, CCND2, CCNG1

GO Terms for genes affiliated with Mantle Cell Lymphoma

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16Gene Ontology
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Cellular components related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:00030710.6CCND2, CCND1

Biological processes related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cyclin-dependent protein kinase activityGO:04573710.6CCND2, CCND1
2response to X-rayGO:01016510.6CCND1, PMAIP1
3positive regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351710.5ATM, PMAIP1
4response to organonitrogen compoundGO:01024310.3CCNG1, CCND1

Products for genes affiliated with Mantle Cell Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mantle Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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