LCM
MCID: MNT001
MIFTS: 67

Mantle Cell Lymphoma (LCM) malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Mantle Cell Lymphoma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Mantle cell lymphoma (mcl) belongs to a group of diseases known as  non-hodgkin’s lymphomas (nhl), which are cancers that affect the the lymphatic system (part of the immune system). mcl accounts for 6% of all non-hodgkin lymphomas and is mostly found in males during their early 60s. lymphocytes, which are white blood cells that make up the lymphatic system. there are two main types: b-lymphocytes (b-cells) and t-lymphocytes (t-cells). mantel cell lymphoma is a b-cell lymphoma that develops from cancerous b-cells within a region of the lymph node known as the mantle zone. although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time. last updated: 7/20/2011

MalaCards: Mantle Cell Lymphoma, also known as lymphoma, mantle cell, is related to leukemia and chronic lymphocytic leukemia, and has symptoms including hematologic/blood/lymphatic cancer, splenomegaly and anorexia. An important gene associated with Mantle Cell Lymphoma is ATM (ataxia telangiectasia mutated), and among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR. The compounds rapamycin and mimosine have been mentioned in the context of this disorder. Affiliated tissues include b cells, lymph node and t cells, and related mouse phenotypes are cellular and hematopoietic system.

Disease Ontology:8 A b-cell lymphocytic neoplasm due to cd5 positive antigen-naive pregerminal center b-cell within the mantle zone that surrounds normal germinal center follicles.

Wikipedia:63 Mantle cell lymphoma (MCL) is one of the rarest of the non-Hodgkin\'s lymphomas (NHLs), comprising about... more...

Aliases & Classifications for Mantle Cell Lymphoma

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
mantle cell lymphoma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

mantle cell lymphoma 8 42 10 48 30
lymphoma, mantle cell 42 22 46
malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 60
malignant lymphoma - lymphocytic, intermediate differentiation 60
mucocutaneous lymph node syndrome 60
lymphocytic choriomeningitis 60
mantle zone lymphoma 48
lymphoma mantle-cell 44
lcm 48
mcl 48


External Ids:

Disease Ontology8 DOID:0050746
MESH via Orphanet35 D020522
ICD10 via Orphanet26 C83.1
SNOMED-CT via Orphanet57 443487006, 74654000
ICD1025 C83.1

Related Diseases for Mantle Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Mantle Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.3CCND1, CCND2, CCNG1, ATM, PRAME, IGH
2chronic lymphocytic leukemia31.1IGHM, ATM, CCND2, CD5, CCND1, IGH
3non-hodgkin lymphoma30.9CCND1, IGH, CD5, ATM, CCND2, CCNG1
4hodgkin's lymphoma30.9IGHM, IGH, ATM, CCNG1, CCND2
5myeloma30.7IGH, IGHM, CCND2, CCND1
6multiple myeloma30.6CCND2, CCND1
7macroglobulinemia30.5CD5
8prolymphocytic leukemia30.4CCND1, ATM, CD5
9acute leukemia30.4IGH, ATM, PRAME
10burkitt's lymphoma30.4CCND1, ATM
11prostate cancer30.2ATM, CCNG1, CCND2, CCND1
12adenocarcinoma30.2CCND2, CCNG1, CCND1
13retinoblastoma30.2CCND2, CCNG1, CCND1
14plasmacytoma30.2IGH
15bone lymphoma10.6
16diffuse large b-cell lymphoma10.6
17marginal zone b-cell lymphoma10.6
18gastrointestinal lymphoma10.6
19composite lymphoma10.6
20t lymphocyte deficiency10.5
21colon lymphoma10.5
22coronary aneurysm10.5
23central nervous system disease10.5
24meningitis10.5
25nervous system disease10.5
26t cell deficiency10.5
27central nervous system lymphoma10.4
28gastric lymphoma10.4
29orbit lymphoma10.4
30prostate lymphoma10.4
31splenic marginal zone lymphoma10.4
32prostatitis10.4
33adult syndrome10.4
34glomerulonephritis10.4
35hairy cell leukemia10.4
36neuronitis10.4
37chorioretinitis10.4
38influenza10.4
39hydrocephalus10.3
40stomatitis10.3
41lymphocytic choriomeningitis10.3
42membranoproliferative glomerulonephritis10.3
43ataxia telangiectasia10.3
44leukostasis10.3
45gastrointestinal stromal tumor10.3
46anaplastic large cell lymphoma10.3
47interstitial nephritis10.3
48squamous cell carcinoma10.3
49thrombocytopenia10.3
50tetralogy of fallot10.3

Graphical network of the top 20 diseases related to Mantle Cell Lymphoma:



Diseases related to mantle cell lymphoma

Clinical Features for Mantle Cell Lymphoma

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48Orphanet
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Symptoms:

48 (show all 7)
  • hematologic/blood/lymphatic cancer
  • splenomegaly
  • anorexia
  • bone marrow/medullar infiltration
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness
  • lymphadenopathy/polyadenopathies

Drugs & Therapeutics for Mantle Cell Lymphoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Mantle Cell Lymphoma

Search NIH Clinical Center for Mantle Cell Lymphoma

Search CenterWatch for Mantle Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Mantle Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Mantle Cell Lymphoma

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22GTR
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Genetic tests related to Mantle Cell Lymphoma:

id Genetic test Affiliating Genes
1 Mantle Cell Lymphoma22

Anatomical Context for Mantle Cell Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Mantle Cell Lymphoma:

32
B cells, Lymph node, T cells, Bone, Bone marrow, Colon, Prostate, Monocytes, Endothelial, Skin, Testis, Testes, Appendix, Myeloid, Trachea, Breast, Adrenal gland, Kidney, Small intestine, Brain, Spleen

Animal Models for Mantle Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mantle Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.1CCND1, CCND2, CCNG1, SOX11, PIM2, ATM
2MP:000539710.8CD5, PMAIP1, CCND1, CCND2, SOX11, PIM2

Publications for Mantle Cell Lymphoma

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50PubMed
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Articles related to Mantle Cell Lymphoma:

(show top 50)    (show all 839)
idTitleAuthorsYear
1
Abnormal serum free light chain ratio predicts poor overall survival in mantle cell lymphoma. (23094783)
2013
2
SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma. (23321250)
2013
3
Single-agent lenalidomide in patients with mantle-cell lymphoma who relapsed or progressed after or were refractory to bortezomib: phase II MCL-001 (EMERGE) study. (24002500)
2013
4
Combination of rituximab, bendamustine, and cytarabine for patients with mantle-cell non-Hodgkin lymphoma ineligible for intensive regimens or autologous transplantation. (23401442)
2013
5
Pertinence of the Sysmex XE-5000a8c parameters: rule of slide review in a context of 'normal' lymphocyte count (defined from control and mantle cell lymphoma blood specimens). (23279807)
2013
6
A cautionary tale for probiotic use in hematopoietic SCT patients-Lactobacillus acidophilus sepsis in a patient with mantle cell lymphoma undergoing hematopoietic SCT. (22890287)
2013
7
Absolute monocyte count at diagnosis and survival in mantle cell lymphoma. (23961917)
2013
8
Gene methylation and silencing of SOCS3 in mantle cell lymphoma. (23432547)
2013
9
Fatal Blastoid Variant Mantle Cell Lymphoma in a Patient with SjAPgren's Syndrome. (23710406)
2013
10
Blastoid Mantle Cell Lymphoma With Cutaneous Involvement and Aberrant Immunophenotype. (24061400)
2013
11
Novel therapy for therapy-resistant mantle cell lymphoma: multipronged approach with targeting of hedgehog signaling. (22511234)
2012
12
Multiple polyposis of the esophagus: mantle cell lymphoma. (22516172)
2012
13
Counteracting autophagy overcomes resistance to everolimus in mantle cell lymphoma. (22879389)
2012
14
Role of the microenvironment in mantle cell lymphoma: IL-6 is an important survival factor for the tumor cells. (22968454)
2012
15
New diagnosis of multiple myeloma in a patient with mantle cell lymphoma: Shared genetic factors or simple coincidence? (24371760)
2012
16
Reduced-intensity conditioning allogeneic stem cell transplantation for relapsed/refractory mantle cell lymphoma: a multicenter experience. (22440229)
2012
17
Cloned IGH VDJ targets as tools for personalized minimal residual disease monitoring in mature lymphoid malignancies; a feasibility study in mantle cell lymphoma by the Groupe Ouest Est d'Etude des LeucAcmies et Autres Maladies du Sang. (22626453)
2012
18
Treatment of older patients with mantle-cell lymphoma. (23113500)
2012
19
Prolonged immunochemotherapy with rituximab, cytarabine and fludarabine added to cyclophosphamide, doxorubicin, vincristine and prednisolone and followed by rituximab maintenance in untreated elderly patients with mantle cell lymphoma: a prospective study by the Finnish Lymphoma Group. (22397313)
2012
20
Mantle cell lymphoma successfully treated in a patient with multiple endocrine neoplasia type 2: a rare combination of two malignancies. (21948393)
2012
21
Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features. (22915760)
2012
22
Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities. (22294726)
2012
23
Utility of positron emission tomography scans in mantle cell lymphoma. (21922524)
2011
24
Molecular pathogenesis of mantle cell lymphoma: new perspectives and challenges with clinical implications. (21782057)
2011
25
Lenalidomide synergizes with dexamethasone to induce growth arrest and apoptosis of mantle cell lymphoma cells in vitro and in vivo. (21047686)
2011
26
Stem-like tumor cells confer drug resistant properties to mantle cell lymphoma. (21599592)
2011
27
Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era. (20940415)
2011
28
Use of tissue microarray and automated quantitative analysis for screening and validation of potential biomarkers in mantle cell lymphoma. (20881841)
2011
29
A rare case of t(11;22) in a mantle cell lymphoma like B-cell neoplasia resulting in a fusion of IGL and CCND1: case report. (21457541)
2011
30
Mantle cell lymphoma 12 years after allogeneic bone marrow transplantation occurring simultaneously in recipient and donor. (20733121)
2010
31
SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. (19880778)
2009
32
Exploring mammalian target of rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies. (19757306)
2009
33
Protein profiling of plasma membranes defines aberrant signaling pathways in mantle cell lymphoma. (19346216)
2009
34
Controversies in lymphoma: the role of hematopoietic cell transplantation for mantle cell lymphoma and peripheral T cell lymphoma. (18162229)
2008
35
Inhibition of the p53 E3 ligase HDM-2 induces apoptosis and DNA damage--independent p53 phosphorylation in mantle cell lymphoma. (18765533)
2008
36
Successful treatment of focal segmental glomerulosclerosis in association with mantle cell lymphoma. (17497453)
2007
37
CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma of ocular adnexal origin: usefulness of fluorescence in situ hybridization for distinction between mantle cell lymphoma and MALT lymphoma. (17300675)
2007
38
Promoter methylation of PARG1, a novel candidate tumor suppressor gene in mantle-cell lymphomas. (17488656)
2007
39
Peripheral T-cell lymphoma with involvement of the expanded mantle zone. (16633785)
2006
40
Concurrent herpes simplex viral lymphadenitis and mantle cell lymphoma: a case report and review of the literature. (16594747)
2006
41
Pathogenesis of mantle-cell lymphoma: all oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways. (16155021)
2005
42
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. (15983389)
2005
43
Mantle cell lymphoma. (15548996)
2004
44
Bullous pemphigoid associated with mantle cell lymphoma. (15611428)
2004
45
Nucleolated variant of mantle cell lymphoma with leukemic manifestations mimicking prolymphocytic leukemia. (11865846)
2002
46
Morphological spectrum of cyclin D1-positive mantle cell lymphoma: study of 168 cases. (11881727)
2001
47
Correspondence Re: Chibbar R, Leung K, McCormick S, Ritzkalla K, Strickler J, Staggs R, et al. bcl-1 gene rearrangements in mantle cell lymphoma: a comprehensive analysis of 118 cases, including B-5-fixed tissue, by polymerase chain reaction and southern transfer analysis. Mod Pathol 1998;11:1089-97. (10874676)
2000
48
Immunoglobulin light chain kappa deletion rearrangement as a marker of clonality in mantle cell lymphoma. (10613459)
1999
49
A distinctive composite lymphoma consisting of clonally related mantle cell lymphoma and follicle center cell lymphoma. (10452515)
1999
50
Mantle cell lymphoma: a lymphoproliferative disorder associated with aberrant function of the cell cycle. (8649059)
1996

Genetic Variations for Mantle Cell Lymphoma

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Expression for genes affiliated with Mantle Cell Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mantle Cell Lymphoma

Search GEO for disease gene expression data for Mantle Cell Lymphoma.

Pathways for genes affiliated with Mantle Cell Lymphoma

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Mantle Cell Lymphoma

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44Novoseek, 11DrugBank, 49PharmGKB
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Compounds related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rapamycin4410.7ATM, CCNG1, CCND2, CCND1
2mimosine44 1111.6CCNG1, CCND1
3doxorubicin44 49 1112.5CCND1, CCND2, CCNG1, ATM

GO Terms for genes affiliated with Mantle Cell Lymphoma

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16Gene Ontology
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Cellular components related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:00030710.6CCND2, CCND1

Biological processes related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cyclin-dependent protein kinase activityGO:04573710.6CCND2, CCND1
2response to X-rayGO:01016510.6CCND1, PMAIP1
3positive regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351710.5ATM, PMAIP1
4response to organonitrogen compoundGO:01024310.3CCNG1, CCND1

Products for genes affiliated with Mantle Cell Lymphoma

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Sources for Mantle Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet