Mantle Cell Lymphoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

LCM MCID: MNT001 MIFTS: 67	Mantle Cell Lymphoma (LCM) malady Cancer diseases, Blood diseases, Immune diseases categories
7 symptoms, 237 genes, 21 tissues, 174 related diseases, clinical trials, genetic tests.

Summaries for Mantle Cell Lymphoma

Sources:
⁸Disease Ontology, ⁴²NIH Rare Diseases, ⁶³Wikipedia, ³²MalaCards
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NIH Rare Diseases:⁴² Mantle cell lymphoma (mcl) belongs to a group of diseases known as non-hodgkinâs lymphomas (nhl), which are cancers that affect the the lymphatic system (part of the immune system). mcl accounts for 6% of all non-hodgkin lymphomas and is mostly found in males during their early 60s. lymphocytes, which are white blood cells that make up the lymphatic system. there are two main types: b-lymphocytes (b-cells) and t-lymphocytes (t-cells). mantel cell lymphoma is a b-cell lymphoma that develops from cancerous b-cells within a region of the lymph node known as the mantle zone. although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time. last updated: 7/20/2011

MalaCards: Mantle Cell Lymphoma, also known as lymphoma, mantle cell, is related to leukemia and chronic lymphocytic leukemia, and has symptoms including asthenia/fatigue/weakness, weight loss/loss of appetite/break in weight curve/general health alteration and anorexia. An important gene associated with Mantle Cell Lymphoma is ATM (ataxia telangiectasia mutated), and among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR. The compounds rapamycin and mimosine have been mentioned in the context of this disorder. Affiliated tissues include b cells, lymph node and t cells, and related mouse phenotypes are cellular and hematopoietic system.

Disease Ontology:⁸ A b-cell lymphocytic neoplasm due to cd5 positive antigen-naive pregerminal center b-cell within the mantle zone that surrounds normal germinal center follicles.

Wikipedia:⁶³ Mantle cell lymphoma (MCL) is one of the rarest of the non-Hodgkin\'s lymphomas (NHLs), comprising about... more...

Aliases & Classifications for Mantle Cell Lymphoma

Sources:
⁸Disease Ontology, ⁴²NIH Rare Diseases, ²²GTR, ⁴⁶OMIM, ¹⁰DISEASES, ⁴⁴Novoseek, ⁴⁸Orphanet, ³⁰LifeMap Discovery™, ⁶⁰UMLS, ³⁵MESH via Orphanet, ²⁶ICD10 via Orphanet, ⁵⁷SNOMED-CT via Orphanet, ²⁵ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases

ICD10: ²⁶ ²⁵

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Non-follicular lymphoma

Mantle cell lymphoma

Characteristics (Orphanet epidemiological data):

⁴⁸

mantle cell lymphoma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult

Aliases & Descriptions:

mantle cell lymphoma ⁸ ⁴² ¹⁰ ⁴⁸ ³⁰

lymphoma, mantle cell ⁴² ²² ⁴⁶

malignant lymphoma, lymphocytic, intermediate differentiation, diffuse ⁶⁰

malignant lymphoma - lymphocytic, intermediate differentiation ⁶⁰

mucocutaneous lymph node syndrome ⁶⁰

lymphocytic choriomeningitis ⁶⁰

mantle zone lymphoma ⁴⁸

lymphoma mantle-cell ⁴⁴

lcm ⁴⁸

mcl ⁴⁸

External Ids:

Disease Ontology⁸ DOID:0050746

MESH via Orphanet³⁵ D020522

ICD10 via Orphanet²⁶ C83.1

SNOMED-CT via Orphanet⁵⁷ 443487006, 74654000

ICD10²⁵ C83.1

Related Diseases for Mantle Cell Lymphoma

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Mantle Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 174)

id	Related Disease	Score	Top Affiliating Genes
1	leukemia	31.3	CCND1, CCND2, CCNG1, ATM, PRAME, IGH
2	chronic lymphocytic leukemia	31.1	IGHM, ATM, CCND2, CD5, CCND1, IGH
3	non-hodgkin lymphoma	30.9	CCND1, IGH, CD5, ATM, CCND2, CCNG1
4	hodgkin's lymphoma	30.9	IGHM, IGH, ATM, CCNG1, CCND2
5	myeloma	30.7	IGH, IGHM, CCND2, CCND1
6	multiple myeloma	30.6	CCND2, CCND1
7	macroglobulinemia	30.5	CD5
8	prolymphocytic leukemia	30.4	CCND1, ATM, CD5
9	acute leukemia	30.4	IGH, ATM, PRAME
10	burkitt's lymphoma	30.4	CCND1, ATM
11	prostate cancer	30.2	ATM, CCNG1, CCND2, CCND1
12	adenocarcinoma	30.2	CCND2, CCNG1, CCND1
13	retinoblastoma	30.2	CCND2, CCNG1, CCND1
14	plasmacytoma	30.2	IGH
15	bone lymphoma	10.6
16	diffuse large b-cell lymphoma	10.6
17	marginal zone b-cell lymphoma	10.6
18	gastrointestinal lymphoma	10.6
19	composite lymphoma	10.6
20	t lymphocyte deficiency	10.5
21	colon lymphoma	10.5
22	coronary aneurysm	10.5
23	central nervous system disease	10.5
24	meningitis	10.5
25	nervous system disease	10.5
26	t cell deficiency	10.5
27	central nervous system lymphoma	10.4
28	gastric lymphoma	10.4
29	orbit lymphoma	10.4
30	prostate lymphoma	10.4
31	splenic marginal zone lymphoma	10.4
32	prostatitis	10.4
33	adult syndrome	10.4
34	glomerulonephritis	10.4
35	hairy cell leukemia	10.4
36	neuronitis	10.4
37	chorioretinitis	10.4
38	influenza	10.4
39	hydrocephalus	10.3
40	stomatitis	10.3
41	lymphocytic choriomeningitis	10.3
42	membranoproliferative glomerulonephritis	10.3
43	ataxia telangiectasia	10.3
44	leukostasis	10.3
45	gastrointestinal stromal tumor	10.3
46	anaplastic large cell lymphoma	10.3
47	interstitial nephritis	10.3
48	squamous cell carcinoma	10.3
49	thrombocytopenia	10.3
50	tetralogy of fallot	10.3

Graphical network of the top 20 diseases related to Mantle Cell Lymphoma:

Clinical Features for Mantle Cell Lymphoma

Sources:
⁴⁸Orphanet
See all sources

Symptoms:

⁴⁸ (show all 7)

asthenia/fatigue/weakness
weight loss/loss of appetite/break in weight curve/general health alteration
anorexia
lymphadenopathy/polyadenopathies

hematologic/blood/lymphatic cancer
bone marrow/medullar infiltration
splenomegaly

Drugs & Therapeutics for Mantle Cell Lymphoma

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ³⁰LifeMap Discovery™, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Mantle Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Mantle Cell Lymphoma

Search NIH Clinical Center for Mantle Cell Lymphoma

Search CenterWatch for Mantle Cell Lymphoma

Cell-based therapeutics:

The database of embryonic development, stem cell research and regenerative medicine

Read about Mantle Cell Lymphoma cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Mantle Cell Lymphoma:

	Blood stem cell transplantation for hematological diseases
	Hematopoietic stem cells for treatment of hematologic malignancies
	Hematopoietic stem cells for treatment of non-Hodgkin's lymphoma
	Peripheral blood stem cells for treatment of hematologic malignancies

Embryonic/Adult Cultured Cells Related to Mantle Cell Lymphoma:

	Peripheral blood-derived hematopoietic stem cells (family)
	Bone marrow-derived hematopoietic stem cells
	Peripheral blood-derived hematopoietic stem cells, PMID: 21831743
	Peripheral blood-derived hematopoietic stem cells (family)

Genetic Tests for Mantle Cell Lymphoma

Sources:
²²GTR
See all sources

Genetic tests related to Mantle Cell Lymphoma:

id	Genetic test	Affiliating Genes
1	Mantle Cell Lymphoma²²

Anatomical Context for Mantle Cell Lymphoma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Mantle Cell Lymphoma:

³²

B cells, Lymph node, T cells, Bone, Bone marrow, Colon, Prostate, Monocytes, Endothelial, Skin, Testis, Adrenal gland, Trachea, Myeloid, Small intestine, Breast, Appendix, Spleen, Kidney, Brain, Testes

Animal Models for Mantle Cell Lymphoma or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Mantle Cell Lymphoma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	11.1	PMAIP1, CCND1, CCND2, CCNG1, SOX11, PIM2
2	hematopoietic system phenotype	MP:0005397	10.8	PMAIP1, CCND1, CCND2, SOX11, PIM2, ATM

Publications for Mantle Cell Lymphoma

Sources:
⁵⁰PubMed
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Articles related to Mantle Cell Lymphoma:

(show top 50) (show all 839)

id	Title	Authors	Year
1	The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma. (24013721)	SA!nchez-TillA^ E.... Postigo A.	2014
2	The NF-I_B pathway is rarely spontaneously activated in mantle cell lymphoma (MCL) cell lines and patient's samples. (24135685)	Camara-Clayette V.... Ribrag V.	2014
3	Retrospective analysis of 235 unselected patients with mantle cell lymphoma confirms prognostic relevance of Mantle Cell Lymphoma International Prognostic Index and Ki-67 in the era of rituximab: long-term data from the Czech Lymphoma Project Database. (23772666)	Salek D.... TrnA9nA1 M.	2013
4	High expression of cyclic nucleotide phosphodiesterase 7B mRNA predicts poor prognosis in mantle cell lymphoma. (23453122)	Fang C.... Li J.Y.	2013
5	Multiple Lymphomatous Polyposis Form of Blastoid Variant of Mantle Cell Lymphoma in Colon: a Case Report and Review of Literature. (23955627)	Haroon S.... Pervez S.	2013
6	Long-term clinical and molecular remissions in patients with mantle cell lymphoma following high-dose therapy and autologous stem cell transplantation. (24337447)	Metzner B.... Pott C.	2013
7	MicroRNA signature obtained from the comparison of aggressive with indolent non-Hodgkin lymphomas: potential prognostic value in mantle-cell lymphoma. (23835716)	Goswami R.S.... Kamel-Reid S.	2013
8	Cytarabine, Ki-67, and SOX11 in patients with mantle cell lymphoma receiving rituximab-containing autologous stem cell transplantation during first remission. (23775587)	Chakhachiro Z.I.... Khouri I.F.	2013
9	Genome-wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features. (23754783)	Enjuanes A.... Jares P.	2013
10	Prognostic impact of monocyte count at presentation in mantle cell lymphoma - response to Anupkumar etA al. (24251543)	Aprile von Hohenstaufen K.... Zucca E.	2013
11	Measles virus entry through the signaling lymphocyte activation molecule governs efficacy of mantle cell lymphoma radiovirotherapy. (23913184)	Miest T.S.... Cattaneo R.	2013
12	In vivo growth of mantle cell lymphoma xenografts in immunodeficient mice is positively regulated by VEGF and associated with significant up-regulation of CD31/PECAM1. (23537525)	MolinskA1 J.... Klener P.	2013
13	Radioimmunotherapy with 177Lu-DOTA-rituximab: final results of a phase I/II Study in 31 patients with relapsing follicular, mantle cell, and other indolent B-cell lymphomas. (23572496)	Forrer F.... Lohri A.	2013
14	Prognostic impact of monocyte count at presentation in mantle cell lymphoma. (24266507)	George A.... Ritchie D.S.	2013
15	Refining the predictors of risk for central nervous system involvement in patients with mantle cell lymphoma. (23432685)	Cheah C.Y.... Seymour J.F.	2013
16	Combination of atiprimod and the proteasome inhibitor bortezomib induces apoptosis of mantle cell lymphoma in vitro and in vivo. (22000823)	Sun L.... Wang M.	2012
17	Allogeneic hematopoietic cell transplantation in mantle cell lymphoma. (22687452)	Cassaday R.D.... Gopal A.K.	2012
18	Successful treatment with tandem consolidation using 90yttrium-ibritumomab tiuxetan (Zevalin) and high-dose therapy with autologous PBSCT in a patient with relapsed mantle cell lymphoma presenting as multiple lymphomatous polyposis. (21946384)	Han E.J.... Cho S.G.	2012
19	Optimized adoptive T-cell therapy for the treatment of residual mantle cell lymphoma. (22441656)	Munger C.M.... Joshi S.S.	2012
20	Primary mantle cell lymphoma of the trachea. (22392198)	Guddati A.K.... Marak C.P.	2012
21	Colonic in situ mantle cell lymphoma. (21840231)	Neto A.G.... Torres R.	2012
22	Novel targeted therapies for mantle cell lymphoma. (22361516)	Alinari L.... Baiocchi R.A.	2012
23	Detection of minimal residual disease following induction immunochemotherapy predicts progression free survival in mantle cell lymphoma: final results of CALGB 59909. (22102709)	Liu H.... Stock W.	2012
24	Mantle cell lymphoma. (22082693)	Birgitta S.	2011
25	Quantitative molecular analysis in mantle cell lymphoma. (21887926)	BrA-zovA! H.... Kodet R.	2011
26	Discordant lymphoma consisting of splenic mantle cell lymphoma and marginal zone lymphoma involving the bone marrow and peripheral blood: a case report. (21943040)	Carulli G.... Petrini M.	2011
27	A novel scoring system combining expression of CD23, CD20, and CD38 with platelet count predicts for the presence of the t(11;14) translocation of mantle cell lymphoma. (21462308)	Medd P.G.... Hatton C.S.	2011
28	Identification of proteomic signatures of mantle cell lymphoma, small lymphocytic lymphoma, and marginal zone lymphoma biopsies by surface enhanced laser desorption/ionization-time of flight mass spectrometry. (21438832)	Rolland D.... Thieblemont C.	2011
29	Cutaneous presentation of mantle cell lymphoma. (20814647)	Canpolat F.... Alper M.	2010
30	Ninety-seven Years Old Hispanic Male With Mantle Cell Lymphoma. (21629548)	Thompson B.... Gonzalez M.R.	2010
31	Peritoneal seeding and subsequent progression of mantle cell lymphoma after splenectomy for debulking. (20567628)	Bahat G.... Dogan O.	2010
32	Mantle cell lymphoma in relapse: the role of emerging new drugs. (20679769)	Diefenbach C.S.... O'Connor O.A.	2010
33	Biomarkers as disease definition: mantle cell lymphoma as an example. (21179891)	van Krieken J.H.... Groenen P.J.	2010
34	Preclinical activity of 8-chloroadenosine with mantle cell lymphoma: roles of energy depletion and inhibition of DNA and RNA synthesis. (19709085)	Dennison J.B.... Gandhi V.	2009
35	Mantle cell lymphoma of the gastrointestinal tract presenting with multiple intussusceptions--case report and review of literature. (19646237)	Kella V.K.... King S.	2009
36	Differential diagnosis of cyclin D2+ mantle cell lymphoma based on fluorescence in situ hybridization and quantitative real-time-PCR. (19608671)	Quintanilla-Martinez L.... Fend F.	2009
37	Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma. (18467333)	Hogan C.... Meek D.	2008
38	Blastic mantle cell lymphoma with a Burkitt translocation. (18398742)	Reddy K.... Dipasquale B.	2008
39	Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells. (17606765)	Kawamata N.... Koeffler H.P.	2007
40	Proteome- and microarray-based expression analysis of lymphoma cell lines identifies a p53-centered cluster of differentially expressed proteins in mantle cell and follicular lymphoma. (17990259)	Weinkauf M.... Dreyling M.	2007
41	Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma. (17627275)	Pal S.... Sif S.	2007
42	Retinoic acid inhibits the proliferative response induced by CD40 activation and interleukin-4 in mantle cell lymphoma. (15695403)	Guidoboni M.... Dolcetti R.	2005
43	Aberrant Bcl6 protein expression in mantle cell lymphoma. (15252312)	Camacho F.I.... Piris M.A.	2004
44	Identification of genes whose expression patterns differ in benign lymphoid tissue and follicular, mantle cell, and small lymphocytic lymphoma. (14961037)	Schmechel S.C.... Sabath D.E.	2004
45	Quantitation of cyclin D1 over-expression using competitive fluorescent reverse transcription polymerase chain reaction: a tool for the differential diagnosis of mantle cell lymphoma. (12665688)	Wickham C.L.... Ellard S.	2003
46	The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma. (11298590)	Visser H.P.... Otte A.P.	2001
47	Immunoglobulin V(H) gene mutational analysis suggests that blastic variant of mantle cell lymphoma derives from different stages of B-cell maturation. (10634642)	LA!szlA^ T.... Matolcsy A.	2000
48	BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like. (11072235)	Mertens D.... Lichter P.	2000
49	Mantle cell lymphoma in leukemic phase: characterization of its broad cytologic spectrum with emphasis on the importance of distinction from other chronic lymphoproliferative disorders. (10463985)	Wong K.F.... Yu P.H.	1999
50	Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. (7812213)	Hirokawa M.... Miura A.B.	1994

Genes related to Mantle Cell Lymphoma

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc., ⁴⁶OMIM, ⁴⁸Orphanet
See all sources

Genes related to Mantle Cell Lymphoma:

(show top 50) (show all 237)

id	Symbol	Description	Score	Implication
1	ATM	ataxia telangiectasia mutated	20.04	Molecular basis known ⁴⁶ Causative somatic mutation ⁴⁸ GeneCards inferred : Publications, Disorders, Functions (show sections)
2	CCND1	cyclin D1	19.96	Causative somatic mutation ⁴⁸ GeneCards inferred : Publications, Disorders, Functions (show sections)
3	IGH	immunoglobulin heavy locus	19.83	Causative somatic mutation ⁴⁸ GeneCards inferred : Publications (show sections)
4	CD5	CD5 molecule	19.79	GeneCards inferred : Publications, Disorders (show sections)
5	MIR17	microRNA 17	19.70	GeneCards inferred : Publications, Disorders (show sections)
6	MIR16-1	microRNA 16-1	19.62	GeneCards inferred : Publications, Disorders (show sections)
7	MIR17HG	miR-17-92 cluster host gene (non-protein coding)	19.53	GeneCards inferred : Publications, Disorders (show sections)
8	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	19.45	GeneCards inferred : Publications, Disorders (show sections)
9	IGHM	immunoglobulin heavy constant mu	19.37	GeneCards inferred : Publications, Disorders (show sections)
10	SOX11	SRY (sex determining region Y)-box 11	19.28	GeneCards inferred : Publications, Disorders (show sections)
11	CCND2	cyclin D2	19.20	GeneCards inferred : Publications, Disorders (show sections)
12	NTN3	netrin 3	19.11	GeneCards inferred : Publications, Disorders (show sections)
13	MIR20A	microRNA 20a	19.03	GeneCards inferred : Publications, Disorders (show sections)
14	CCNG1	cyclin G1	18.94	GeneCards inferred : Publications, Disorders (show sections)
15	PIM2	pim-2 oncogene	18.86	GeneCards inferred : Publications, Disorders (show sections)
16	TRIM13	tripartite motif containing 13	18.77	GeneCards inferred : Publications, Disorders (show sections)
17	HILPDA	hypoxia inducible lipid droplet-associated	18.69	GeneCards inferred : Publications, Disorders (show sections)
18	MIR29A	microRNA 29a	18.61	GeneCards inferred : Publications, Disorders (show sections)
19	DLEU2L	deleted in lymphocytic leukemia 2-like	18.52	GeneCards inferred : Publications, Disorders (show sections)
20	PRAME	preferentially expressed antigen in melanoma	18.44	GeneCards inferred : Publications, Disorders (show sections)
21	CDK20	cyclin-dependent kinase 20	18.35	GeneCards inferred : Publications, Disorders (show sections)
22	CKS1B	CDC28 protein kinase regulatory subunit 1B	18.27	GeneCards inferred : Publications, Disorders (show sections)
23	MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	18.18	GeneCards inferred : Publications, Disorders (show sections)
24	TNFSF9	tumor necrosis factor (ligand) superfamily, member 9	18.10	GeneCards inferred : Publications, Disorders (show sections)
25	HIC1	hypermethylated in cancer 1	18.02	GeneCards inferred : Publications, Disorders (show sections)
26	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	17.93	GeneCards inferred : Publications, Disorders (show sections)
27	IFI27	interferon, alpha-inducible protein 27	17.85	GeneCards inferred : Publications, Disorders (show sections)
28	AICDA	activation-induced cytidine deaminase	17.76	GeneCards inferred : Publications, Disorders (show sections)
29	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	17.68	GeneCards inferred : Publications, Disorders (show sections)
30	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	17.59	GeneCards inferred : Publications, Disorders (show sections)
31	CD19	CD19 molecule	17.51	GeneCards inferred : Publications, Disorders (show sections)
32	WNT10A	wingless-type MMTV integration site family, member 10A	17.42	GeneCards inferred : Publications, Disorders (show sections)
33	ING1	inhibitor of growth family, member 1	17.34	GeneCards inferred : Publications, Disorders (show sections)
34	TCL1A	T-cell leukemia/lymphoma 1A	17.26	GeneCards inferred : Publications, Disorders (show sections)
35	DUSP5	dual specificity phosphatase 5	17.17	GeneCards inferred : Publications, Disorders (show sections)
36	CXCR5	chemokine (C-X-C motif) receptor 5	17.09	GeneCards inferred : Publications, Disorders (show sections)
37	SETMAR	SET domain and mariner transposase fusion gene	17.00	GeneCards inferred : Publications, Disorders (show sections)
38	CCL19	chemokine (C-C motif) ligand 19	16.92	GeneCards inferred : Publications, Disorders (show sections)
39	CD70	CD70 molecule	16.83	GeneCards inferred : Publications, Disorders (show sections)
40	RGS13	regulator of G-protein signaling 13	16.75	GeneCards inferred : Publications, Disorders (show sections)
41	CD52	CD52 molecule	16.67	GeneCards inferred : Publications, Disorders (show sections)
42	EMC3	ER membrane protein complex subunit 3	16.58	GeneCards inferred : Publications, Disorders (show sections)
43	BCL6	B-cell CLL/lymphoma 6	16.50	GeneCards inferred : Publications, Disorders (show sections)
44	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	16.41	GeneCards inferred : Publications, Disorders (show sections)
45	MDM2	MDM2 oncogene, E3 ubiquitin protein ligase	16.33	GeneCards inferred : Publications, Disorders (show sections)
46	CDK4	cyclin-dependent kinase 4	16.24	GeneCards inferred : Publications, Disorders (show sections)
47	CCND3	cyclin D3	16.16	GeneCards inferred : Publications, Disorders (show sections)
48	PIM1	pim-1 oncogene	16.07	GeneCards inferred : Publications, Disorders (show sections)
49	DVL2	dishevelled segment polarity protein 2	15.99	GeneCards inferred : Publications, Disorders (show sections)
50	ADSS	adenylosuccinate synthase	15.91	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Mantle Cell Lymphoma disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	40	40	41
2	LSBio	-	-	50

Genetic Variations for Mantle Cell Lymphoma

Expression for genes affiliated with Mantle Cell Lymphoma

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Mantle Cell Lymphoma

Search GEO for disease gene expression data for Mantle Cell Lymphoma.

Pathways for genes affiliated with Mantle Cell Lymphoma

Sources:
²⁹KEGG, ³⁷NCBI BioSystems Database, ⁵¹QIAGEN, ⁵³Reactome, ¹²EMD Millipore
See all sources

Pathways related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	MicroRNAs in cancer²⁹	11.1	CCND1, CCND2, CCNG1, ATM, MIR20A, MIR17
2	miRNAs involved in DDR³⁷	10.9	MIR16-1, CCND1, ATM, MIR20A, MIR17, MIR29A
3	p53 signaling pathway²⁹ Hide members DNA damage response³⁷	10.8	PMAIP1, CCND1, CCND2, CCNG1, ATM
4	Wnt Signaling Pathway³⁷ Hide members DNA damage response (only ATM dependent)³⁷ Wnt Signaling Pathway and Pluripotency³⁷	10.8	PMAIP1, CCND1, CCND2, ATM
5	GADD45 Pathway⁵¹	10.8	CCND1, CCND2, CCNG1, ATM
6	Mitotic G1-G1/S phases⁵³ Hide members G1 to S cell cycle control³⁷	10.7	ATM, CCND2, CCND1
7	Cell cycle²⁹ Hide members Cell cycle³⁷	10.7	ATM, CCND2, CCND1
8	Cyclins and Cell Cycle Regulation⁵¹ Hide members G1-S Phase Transition⁵¹ G1 Phase⁵³ Cyclin D associated events in G1⁵³ Cell Cycle Control by BTG Proteins⁵¹	10.7	CCND1, CCND2, ATM
9	DNA damage ATM/ATR regulation of G1/S checkpoint¹²	10.7	ATM, CCND2, CCND1
10	TP53 network³⁷	10.6	ATM, PMAIP1

Compounds for genes affiliated with Mantle Cell Lymphoma

Sources:
⁴⁴Novoseek, ¹¹DrugBank, ⁴⁹PharmGKB
See all sources

Compounds related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	rapamycin⁴⁴	10.7	CCNG1, CCND1, CCND2, ATM
2	mimosine⁴⁴ ¹¹	11.6	CCNG1, CCND1
3	doxorubicin⁴⁴ ⁴⁹ ¹¹	12.5	ATM, CCND1, CCND2, CCNG1

GO Terms for genes affiliated with Mantle Cell Lymphoma

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cyclin-dependent protein kinase holoenzyme complex	GO:000307	10.6	CCND2, CCND1

Biological processes related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cyclin-dependent protein kinase activity	GO:045737	10.6	CCND2, CCND1
2	response to X-ray	GO:010165	10.6	CCND1, PMAIP1
3	positive regulation of DNA damage response, signal transduction by p53 class mediator	GO:043517	10.5	ATM, PMAIP1
4	response to organonitrogen compound	GO:010243	10.3	CCNG1, CCND1