LCM
MCID: MNT001
MIFTS: 67

Mantle Cell Lymphoma (LCM) malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Mantle Cell Lymphoma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Mantle cell lymphoma (mcl) belongs to a group of diseases known as  non-hodgkin’s lymphomas (nhl), which are cancers that affect the the lymphatic system (part of the immune system). mcl accounts for 6% of all non-hodgkin lymphomas and is mostly found in males during their early 60s. lymphocytes, which are white blood cells that make up the lymphatic system. there are two main types: b-lymphocytes (b-cells) and t-lymphocytes (t-cells). mantel cell lymphoma is a b-cell lymphoma that develops from cancerous b-cells within a region of the lymph node known as the mantle zone. although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time. last updated: 7/20/2011

MalaCards: Mantle Cell Lymphoma, also known as lymphoma, mantle cell, is related to leukemia and chronic lymphocytic leukemia, and has symptoms including asthenia/fatigue/weakness, weight loss/loss of appetite/break in weight curve/general health alteration and anorexia. An important gene associated with Mantle Cell Lymphoma is ATM (ataxia telangiectasia mutated), and among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR. The compounds rapamycin and mimosine have been mentioned in the context of this disorder. Affiliated tissues include b cells, lymph node and t cells, and related mouse phenotypes are cellular and hematopoietic system.

Disease Ontology:8 A b-cell lymphocytic neoplasm due to cd5 positive antigen-naive pregerminal center b-cell within the mantle zone that surrounds normal germinal center follicles.

Wikipedia:63 Mantle cell lymphoma (MCL) is one of the rarest of the non-Hodgkin\'s lymphomas (NHLs), comprising about... more...

Aliases & Classifications for Mantle Cell Lymphoma

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
mantle cell lymphoma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

mantle cell lymphoma 8 42 10 48 30
lymphoma, mantle cell 42 22 46
malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 60
malignant lymphoma - lymphocytic, intermediate differentiation 60
mucocutaneous lymph node syndrome 60
lymphocytic choriomeningitis 60
mantle zone lymphoma 48
lymphoma mantle-cell 44
lcm 48
mcl 48


External Ids:

Disease Ontology8 DOID:0050746
MESH via Orphanet35 D020522
ICD10 via Orphanet26 C83.1
SNOMED-CT via Orphanet57 443487006, 74654000
ICD1025 C83.1

Related Diseases for Mantle Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Mantle Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.3CCND1, CCND2, CCNG1, ATM, PRAME, IGH
2chronic lymphocytic leukemia31.1IGHM, ATM, CCND2, CD5, CCND1, IGH
3non-hodgkin lymphoma30.9CCND1, IGH, CD5, ATM, CCND2, CCNG1
4hodgkin's lymphoma30.9IGHM, IGH, ATM, CCNG1, CCND2
5myeloma30.7IGH, IGHM, CCND2, CCND1
6multiple myeloma30.6CCND2, CCND1
7macroglobulinemia30.5CD5
8prolymphocytic leukemia30.4CCND1, ATM, CD5
9acute leukemia30.4IGH, ATM, PRAME
10burkitt's lymphoma30.4CCND1, ATM
11prostate cancer30.2ATM, CCNG1, CCND2, CCND1
12adenocarcinoma30.2CCND2, CCNG1, CCND1
13retinoblastoma30.2CCND2, CCNG1, CCND1
14plasmacytoma30.2IGH
15bone lymphoma10.6
16diffuse large b-cell lymphoma10.6
17marginal zone b-cell lymphoma10.6
18gastrointestinal lymphoma10.6
19composite lymphoma10.6
20t lymphocyte deficiency10.5
21colon lymphoma10.5
22coronary aneurysm10.5
23central nervous system disease10.5
24meningitis10.5
25nervous system disease10.5
26t cell deficiency10.5
27central nervous system lymphoma10.4
28gastric lymphoma10.4
29orbit lymphoma10.4
30prostate lymphoma10.4
31splenic marginal zone lymphoma10.4
32prostatitis10.4
33adult syndrome10.4
34glomerulonephritis10.4
35hairy cell leukemia10.4
36neuronitis10.4
37chorioretinitis10.4
38influenza10.4
39hydrocephalus10.3
40stomatitis10.3
41lymphocytic choriomeningitis10.3
42membranoproliferative glomerulonephritis10.3
43ataxia telangiectasia10.3
44leukostasis10.3
45gastrointestinal stromal tumor10.3
46anaplastic large cell lymphoma10.3
47interstitial nephritis10.3
48squamous cell carcinoma10.3
49thrombocytopenia10.3
50tetralogy of fallot10.3

Graphical network of the top 20 diseases related to Mantle Cell Lymphoma:



Diseases related to mantle cell lymphoma

Clinical Features for Mantle Cell Lymphoma

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48Orphanet
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Symptoms:

48 (show all 7)
  • asthenia/fatigue/weakness
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • anorexia
  • lymphadenopathy/polyadenopathies
  • hematologic/blood/lymphatic cancer
  • bone marrow/medullar infiltration
  • splenomegaly

Drugs & Therapeutics for Mantle Cell Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mantle Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Mantle Cell Lymphoma

Search NIH Clinical Center for Mantle Cell Lymphoma

Search CenterWatch for Mantle Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Mantle Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Mantle Cell Lymphoma

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22GTR
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Genetic tests related to Mantle Cell Lymphoma:

id Genetic test Affiliating Genes
1 Mantle Cell Lymphoma22

Anatomical Context for Mantle Cell Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Mantle Cell Lymphoma:

32
B cells, Lymph node, T cells, Bone, Bone marrow, Colon, Prostate, Monocytes, Endothelial, Skin, Testis, Adrenal gland, Trachea, Myeloid, Small intestine, Breast, Appendix, Spleen, Kidney, Brain, Testes

Animal Models for Mantle Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mantle Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.1PMAIP1, CCND1, CCND2, CCNG1, SOX11, PIM2
2MP:000539710.8PMAIP1, CCND1, CCND2, SOX11, PIM2, ATM

Publications for Mantle Cell Lymphoma

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50PubMed
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Articles related to Mantle Cell Lymphoma:

(show top 50)    (show all 839)
idTitleAuthorsYear
1
The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma. (24013721)
2014
2
The NF-I_B pathway is rarely spontaneously activated in mantle cell lymphoma (MCL) cell lines and patient's samples. (24135685)
2014
3
Retrospective analysis of 235 unselected patients with mantle cell lymphoma confirms prognostic relevance of Mantle Cell Lymphoma International Prognostic Index and Ki-67 in the era of rituximab: long-term data from the Czech Lymphoma Project Database. (23772666)
2013
4
High expression of cyclic nucleotide phosphodiesterase 7B mRNA predicts poor prognosis in mantle cell lymphoma. (23453122)
2013
5
Multiple Lymphomatous Polyposis Form of Blastoid Variant of Mantle Cell Lymphoma in Colon: a Case Report and Review of Literature. (23955627)
2013
6
Long-term clinical and molecular remissions in patients with mantle cell lymphoma following high-dose therapy and autologous stem cell transplantation. (24337447)
2013
7
MicroRNA signature obtained from the comparison of aggressive with indolent non-Hodgkin lymphomas: potential prognostic value in mantle-cell lymphoma. (23835716)
2013
8
Cytarabine, Ki-67, and SOX11 in patients with mantle cell lymphoma receiving rituximab-containing autologous stem cell transplantation during first remission. (23775587)
2013
9
Genome-wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features. (23754783)
2013
10
Prognostic impact of monocyte count at presentation in mantle cell lymphoma - response to Anupkumar etA al. (24251543)
2013
11
Measles virus entry through the signaling lymphocyte activation molecule governs efficacy of mantle cell lymphoma radiovirotherapy. (23913184)
2013
12
In vivo growth of mantle cell lymphoma xenografts in immunodeficient mice is positively regulated by VEGF and associated with significant up-regulation of CD31/PECAM1. (23537525)
2013
13
Radioimmunotherapy with 177Lu-DOTA-rituximab: final results of a phase I/II Study in 31 patients with relapsing follicular, mantle cell, and other indolent B-cell lymphomas. (23572496)
2013
14
Prognostic impact of monocyte count at presentation in mantle cell lymphoma. (24266507)
2013
15
Refining the predictors of risk for central nervous system involvement in patients with mantle cell lymphoma. (23432685)
2013
16
Combination of atiprimod and the proteasome inhibitor bortezomib induces apoptosis of mantle cell lymphoma in vitro and in vivo. (22000823)
2012
17
Allogeneic hematopoietic cell transplantation in mantle cell lymphoma. (22687452)
2012
18
Successful treatment with tandem consolidation using 90yttrium-ibritumomab tiuxetan (Zevalin) and high-dose therapy with autologous PBSCT in a patient with relapsed mantle cell lymphoma presenting as multiple lymphomatous polyposis. (21946384)
2012
19
Optimized adoptive T-cell therapy for the treatment of residual mantle cell lymphoma. (22441656)
2012
20
Primary mantle cell lymphoma of the trachea. (22392198)
2012
21
Colonic in situ mantle cell lymphoma. (21840231)
2012
22
Novel targeted therapies for mantle cell lymphoma. (22361516)
2012
23
Detection of minimal residual disease following induction immunochemotherapy predicts progression free survival in mantle cell lymphoma: final results of CALGB 59909. (22102709)
2012
24
Mantle cell lymphoma. (22082693)
2011
25
Quantitative molecular analysis in mantle cell lymphoma. (21887926)
2011
26
Discordant lymphoma consisting of splenic mantle cell lymphoma and marginal zone lymphoma involving the bone marrow and peripheral blood: a case report. (21943040)
2011
27
A novel scoring system combining expression of CD23, CD20, and CD38 with platelet count predicts for the presence of the t(11;14) translocation of mantle cell lymphoma. (21462308)
2011
28
Identification of proteomic signatures of mantle cell lymphoma, small lymphocytic lymphoma, and marginal zone lymphoma biopsies by surface enhanced laser desorption/ionization-time of flight mass spectrometry. (21438832)
2011
29
Cutaneous presentation of mantle cell lymphoma. (20814647)
2010
30
Ninety-seven Years Old Hispanic Male With Mantle Cell Lymphoma. (21629548)
2010
31
Peritoneal seeding and subsequent progression of mantle cell lymphoma after splenectomy for debulking. (20567628)
2010
32
Mantle cell lymphoma in relapse: the role of emerging new drugs. (20679769)
2010
33
Biomarkers as disease definition: mantle cell lymphoma as an example. (21179891)
2010
34
Preclinical activity of 8-chloroadenosine with mantle cell lymphoma: roles of energy depletion and inhibition of DNA and RNA synthesis. (19709085)
2009
35
Mantle cell lymphoma of the gastrointestinal tract presenting with multiple intussusceptions--case report and review of literature. (19646237)
2009
36
Differential diagnosis of cyclin D2+ mantle cell lymphoma based on fluorescence in situ hybridization and quantitative real-time-PCR. (19608671)
2009
37
Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma. (18467333)
2008
38
Blastic mantle cell lymphoma with a Burkitt translocation. (18398742)
2008
39
Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells. (17606765)
2007
40
Proteome- and microarray-based expression analysis of lymphoma cell lines identifies a p53-centered cluster of differentially expressed proteins in mantle cell and follicular lymphoma. (17990259)
2007
41
Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma. (17627275)
2007
42
Retinoic acid inhibits the proliferative response induced by CD40 activation and interleukin-4 in mantle cell lymphoma. (15695403)
2005
43
Aberrant Bcl6 protein expression in mantle cell lymphoma. (15252312)
2004
44
Identification of genes whose expression patterns differ in benign lymphoid tissue and follicular, mantle cell, and small lymphocytic lymphoma. (14961037)
2004
45
Quantitation of cyclin D1 over-expression using competitive fluorescent reverse transcription polymerase chain reaction: a tool for the differential diagnosis of mantle cell lymphoma. (12665688)
2003
46
The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma. (11298590)
2001
47
Immunoglobulin V(H) gene mutational analysis suggests that blastic variant of mantle cell lymphoma derives from different stages of B-cell maturation. (10634642)
2000
48
BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like. (11072235)
2000
49
Mantle cell lymphoma in leukemic phase: characterization of its broad cytologic spectrum with emphasis on the importance of distinction from other chronic lymphoproliferative disorders. (10463985)
1999
50
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. (7812213)
1994

Genetic Variations for Mantle Cell Lymphoma

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Expression for genes affiliated with Mantle Cell Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mantle Cell Lymphoma

Search GEO for disease gene expression data for Mantle Cell Lymphoma.

Pathways for genes affiliated with Mantle Cell Lymphoma

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Mantle Cell Lymphoma

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44Novoseek, 11DrugBank, 49PharmGKB
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Compounds related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rapamycin4410.7CCNG1, CCND1, CCND2, ATM
2mimosine44 1111.6CCNG1, CCND1
3doxorubicin44 49 1112.5ATM, CCND1, CCND2, CCNG1

GO Terms for genes affiliated with Mantle Cell Lymphoma

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16Gene Ontology
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Cellular components related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:00030710.6CCND2, CCND1

Biological processes related to Mantle Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cyclin-dependent protein kinase activityGO:04573710.6CCND2, CCND1
2response to X-rayGO:01016510.6CCND1, PMAIP1
3positive regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351710.5ATM, PMAIP1
4response to organonitrogen compoundGO:01024310.3CCNG1, CCND1

Products for genes affiliated with Mantle Cell Lymphoma

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Sources for Mantle Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet