Marasmus malady

Wikipedia: Marasmus is a form of severe malnutrition characterized by energy deficiency. A child with marasmus...⁴⁴ more...

MalaCards: Marasmus, also known as nutritional marasmus (disorder), is related to kwashiorkor and anorexia nervosa. An important gene associated with Marasmus is LSL (Leptin, serum levels of), and among its related pathways is Selected targets of C/EBPalpha. The compounds carbohydrates and estradiol have been mentioned in the context of this disorder.

Aliases & Descriptions:

marasmus 6 32 43 nutritional marasmus (disorder) 6

nutritional marasmus 6 nutritional atrophy 6

Diseases related to marasmus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 199)

id	Related Disease	Score	Top Affiliating Genes
1	kwashiorkor	29.5	SHBG, ALB, ANXA6
2	anorexia nervosa	26.1	LSL, SHBG, GH1, ALB, IGFBP3
3	protein-energy malnutrition	24.8	TF, LSL, SHBG, ALB, IGFBP3, ANXA6
4	leptin deficiency	13.2	LSL, GH1
5	insulin-like growth factor 1 resistance to	13.2	GH1, IGFBP3
6	rabson-mendenhall syndrome	13.1	GH1, IGFBP3
7	idiopathic juvenile osteoporosis	13.1	GH1, IGFBP3
8	delayed puberty	13.1	LSL, IGFBP3
9	acid-labile subunit	13.1	GH1, IGFBP3
10	growth disorders	13.1	GH1, IGFBP3
11	combined pituitary hormone deficiency	13.1	GH1, IGFBP3
12	11-beta-hydroxylase deficiency	13.1	GH1, SHBG
13	pituitary hormone deficiency	13.1	GH1, IGFBP3
14	hypoadrenalism	13.1	SHBG, GH1
15	osteopenia/osteoporosis	13.0	IGFBP3, GH1
16	mccune albright syndrome	13.0	IGFBP3, GH1
17	fragile x-associated primary ovarian insufficiency	13.0	SHBG, GH1
18	transsexualism	13.0	SHBG, LSL
19	siderosis	13.0	TF, IGFBP3
20	acanthosis nigricans	13.0	SHBG, GH1
21	neuroectodermal endocrine syndrome	13.0	GH1, SHBG
22	premature ovarian failure	13.0	SHBG, IGFBP3
23	metabolic syndrome x	13.0	LSL, ALB
24	anovulation	12.9	SHBG, IGFBP3
25	gestational diabetes	12.9	LSL, SHBG
26	yellow nail syndrome	12.9	TF, ALB
27	prostatic hypertrophy	12.9	SHBG, IGFBP3
28	cystinosis	12.8	ALB, GH1
29	protein-losing enteropathy	12.8	TF, ALB
30	diabetic ketoacidosis	12.8	LSL, ALB
31	lipoid nephrosis	12.8	TF, ALB
32	androgen insensitivity syndrome	12.8	SHBG, TF
33	uterine fibroid	12.8	LSL, SHBG
34	laron syndrome	12.8	IGFBP3, GH1, LSL
35	thyrotoxicosis	12.8	ALB, GH1
36	chronic kidney failure	12.8	TF, ALB
37	virilization	12.8	LSL, SHBG
38	short bowel syndrome	12.8	GH1, ALB
39	severe pre-eclampsia	12.8	LSL, ALB
40	dysphagia	12.8	TF, ALB
41	steroid-resistant nephrotic syndrome	12.8	ALB, TF
42	opiate dependence	12.8	ALB, TF
43	fanconi syndrome	12.8	TF, ALB
44	lipodystrophy	12.7	LSL, GH1, IGFBP3
45	prader-willi syndrome	12.7	LSL, GH1, IGFBP3
46	pure red-cell aplasia	12.7	TF, ALB
47	hypothyroidism	12.7	IGFBP3, SHBG, LSL
48	porphyria cutanea tarda	12.7	TF, ALB
49	iron deficiency anemia	12.7	ALB, TF
50	thyroid hormone resistance syndrome	12.7	IGFBP3, GH1, SHBG

Approved drugs:

Drug clinical trials:

Articles related to marasmus:

id	Title	Authors	Year	Affiliating Genes
1	Serum concentrations of sex hormone binding globulin are elevated in kwashiorkor and anorexia nervosa but not in marasmus. (12081841)	Pascal N.... Gueant J.L.	2002	SHBG
2	Plasma fatty acids in children with grade III protein-energy malnutrition in its different clinical forms: marasmus, marasmic kwashiorkor, and kwashiorkor. (10341499)	Franco V.H.... dos Santos J.E.	1999	ANXA6
3	Whole-body protein kinetics in marasmus and kwashiorkor during acute infection. (9625094)	Manary M.J.... Yarasheski K.E.	1998	ALB

Genes related to marasmus according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	LSL	Leptin, serum levels of	11.0
2	TF	transferrin	11.0
3	IGFBP3	insulin-like growth factor binding protein 3	11.0
4	GH1	growth hormone 1	11.0
5	ALB	albumin	11.0	Publications
6	ANXA6	annexin A6	11.0	Publications
7	SHBG	sex hormone-binding globulin	11.0	Publications

Pathways related to marasmus according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of C/EBPalpha10	9.4	ALB, TF

Compounds related to marasmus according to GeneDecks:

(show top 50)    (show all 99)

id	Compound	Score	Top Affiliating Genes
1	carbohydrates32	10.4	TF
2	estradiol32 9 18 9	13.3	SHBG
3	c-peptide32	10.0	SHBG, LSL
4	kp-101932	9.8	TF, ALB
5	valproic acid32 34 9 18 9	13.8	ALB
6	Bismuth Subsalicylate9 9	10.6	TF, ALB
7	acth32	9.5	SHBG, IGFBP3, LSL
8	progesterone32 42 9 18 9	13.5	GH1, ANXA6
9	bismuth32 18	10.4	TF, ALB
10	testosterone32 9 18 9	12.4	SHBG, IGFBP3, LSL
11	carbamazepine32 34 9 9	12.4	SHBG, IGFBP3, LSL
12	oxandrolone32 9 9	11.4	GH1, IGFBP3, SHBG
13	Methyltestosterone9 9	10.4	ALB, SHBG
14	clomiphene citrate32	9.3	IGFBP3, GH1, SHBG
15	diazoxide32 42 9 9	12.3	IGFBP3, GH1, SHBG
16	octreotide32 42 9 9	12.3	LSL, IGFBP3, GH1
17	metformin32 34 9 9	12.3	LSL, SHBG, GH1
18	procollagen32	9.3	GH1, LSL, IGFBP3
19	bromocriptine32 9 9	11.3	IGFBP3, GH1, SHBG
20	progestins32	9.2	IGFBP3, GH1, SHBG
21	estrone sulfate32 18	10.2	ALB, SHBG, IGFBP3
22	deoxypyridinoline32	9.0	IGFBP3, SHBG, GH1, LSL
23	dehydroepiandrosterone sulfate32	9.0	SHBG, LSL, GH1, IGFBP3
24	estropipate42 9 9	11.0	ALB, SHBG
25	raloxifene32 9 9	11.0	SHBG, GH1, IGFBP3, LSL
26	hydrocortisone32 9 9	11.0	LSL, SHBG, GH1, TF
27	dhea32	9.0	LSL, SHBG, GH1, IGFBP3
28	triiodothyronine32	9.0	GH1, IGFBP3, SHBG, LSL
29	androstenedione32 18	10.0	LSL, GH1, SHBG, IGFBP3
30	alpha tocopherol32	9.0	IGFBP3, TF, ALB
31	rosiglitazone32 9 18 9	12.0	GH1, IGFBP3, LSL, SHBG
32	glycerol32 9 18 9	12.0	IGFBP3, GH1, SHBG, LSL
33	gnrh32	8.9	IGFBP3, LSL, SHBG, GH1
34	vitamin b1232	8.9	SHBG, ALB, IGFBP3, TF
35	ascorbic acid32 18	9.7	ALB, TF, SHBG, IGFBP3
36	calcitriol32 42 9 18 9	12.7	ALB, GH1, IGFBP3, SHBG
37	creatinine32	8.6	GH1, SHBG, LSL, TF, IGFBP3
38	epinephrine32 9 18 9	11.6	TF, SHBG, GH1, IGFBP3, LSL
39	tamoxifen32 34 9 9	11.6	IGFBP3, LSL, SHBG, TF, GH1
40	vitamin d32	8.6	ALB, IGFBP3, SHBG, GH1
41	norepinephrine32 9 18 9	11.6	IGFBP3, SHBG, LSL, TF, GH1
42	methotrexate32 34 42 9 9	12.5	ALB, TF, LSL, IGFBP3, GH1
43	estrone32 9 18 9	11.4	LSL, SHBG, GH1, ALB, IGFBP3
44	estrogen32	8.3	IGFBP3, LSL, SHBG, GH1, TF
45	prednisolone32 9 9	10.0	IGFBP3, GH1, SHBG, LSL, TF, ALB
46	thyroxine32 18	9.0	GH1, IGFBP3, TF, LSL, SHBG, ALB
47	lactate32	8.0	SHBG, GH1, TF, ALB, IGFBP3, LSL
48	aspartate32	8.0	IGFBP3, ALB, GH1, SHBG, LSL, TF
49	alanine32	8.0	TF, ALB, GH1, SHBG, IGFBP3, LSL
50	cholesterol32 9 18 9	10.7	ALB, ANXA6, IGFBP3, TF, LSL, SHBG

Cellular components related to marasmus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	7.9	IGFBP3, ALB, GH1, SHBG, TF

Biological processes related to marasmus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	9.5	IGFBP3, GH1