MCID: MRS001
MIFTS: 44

Marasmus malady

Metabolic diseases category

Summaries for Marasmus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Marasmus is a form of severe malnutrition characterized by energy deficiency. A child with marasmus... more...

MalaCards: Marasmus, also known as nutritional marasmus, is related to protein-energy malnutrition and hepatitis. An important gene associated with Marasmus is GH1 (growth hormone 1), and among its related pathways is Selected targets of C/EBPalpha. The compounds estradiol and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and bone.

Aliases & Classifications for Marasmus

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

marasmus 8 44 60
nutritional marasmus 8
nutritional atrophy 8


External Ids:

Disease Ontology8 DOID:12328
ICD9CM27 261
MeSH34 D011502
ICD1025 E41

Related Diseases for Marasmus

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Marasmus:



Diseases related to marasmus

Clinical Features for Marasmus

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Drugs & Therapeutics for Marasmus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Marasmus

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Anatomical Context for Marasmus

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32MalaCards
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MalaCards organs/tissues related to Marasmus:

32
Liver, Testes, Bone, Brain, Cortex, Small intestine, Pancreas, Breast, Adrenal cortex

Animal Models for Marasmus or affiliated genes

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Publications for Marasmus

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50PubMed
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Articles related to Marasmus:

(show top 50)    (show all 196)
idTitleAuthorsYear
1
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test. (24114907)
2013
2
The quality of the diet in Malawian children with kwashiorkor and marasmus. (16881921)
2006
3
Plasma fatty acids in children with grade III protein-energy malnutrition in its different clinical forms: marasmus, marasmic kwashiorkor, and kwashiorkor. (10341499)
1999
4
Whole-body protein kinetics in marasmus and kwashiorkor during acute infection. (9625094)
1998
5
Protein-energy malnutrition (kwashiorkor and marasmus). (8699299)
1996
6
The exocrine pancreas in kwashiorkor and marasmus. Light and electron microscopy. (1523833)
1992
7
Traditional perceptions of marasmus in Pakistan. (1901666)
1991
8
Kwashiorkor and marasmus: changing hospital incidence of syndromic presentation (1957-88). (2127923)
1990
9
The long-term effects of early kwashiorkor compared with marasmus. IV. Performance on the national high school entrance examination. (2122403)
1990
10
Peliosis hepatis in a patient with marasmus. (3135227)
1988
11
Biochemical aspects of malabsorption in marasmus: effect of dietary rehabilitation. (3939688)
1985
12
Serum lipids in marasmus. (3934072)
1985
13
Calcium metabolism in marasmus. (6442922)
1984
14
Growth of Nigerian children with marasmus after hospital treatment. (6402601)
1983
15
Gastric function in marasmus. (6427107)
1983
16
Beetle marasmus. (6794839)
1981
17
Pyogenic meningitis in chronic gastroenteritis and marasmus. (402120)
1977
18
Decreased interferon production by leukocytes in marasmus. (180790)
1976
19
Protein-calorie malnutrition in Eygpt. Proteinuria in marasmus. A possible differentiating factor between acutely and chronically developed cases. (829754)
1976
20
Cortisol and growth hormone in kwashiorkor and marasmus. (809848)
1975
21
Letter: Marasmus and kwashiorkor. (807905)
1975
22
Studies on kwashiorkor and marasmus in Calcutta (1957-74): I. Aetiological and clinical studies. (819364)
1975
23
Free catecholamine excretion in the urine in normal infants and in those with marasmus or kwashiorkor. (805224)
1975
24
Marasmus and Pneumocystis carinii pneumonia in institutionalised infants. Observations during an endemic. (4213237)
1974
25
Studies in infantile marasmus. IV. Impairment of immunologic responses in the marasmic pig. (4265256)
1972
26
Phenol marasmus. (5058620)
1972
27
Jejunal disaccharidase activities in children with marasmus and with kwashiorkor. Response to treatment. (5576036)
1971
28
Serum electrophoresis in marasmus. (5571290)
1971
29
Small-intestinal lesion of chronic diarrhoea and marasmus in Iran. (4188341)
1970
30
Serm proteins in kwashiorkor and marasmus. 5. Correlations between hypoproteinaemia and anaemia, oedema and mortality. (5401894)
1969
31
Serum proteins in kwashiorkor and marasmus. 6. Changes with recovery and summary. (5401910)
1969
32
Serum proteins in kwashiorkor and marasmus: 1. Unselected series before treatment. (5713699)
1968
33
Mental development following nutritional marasmus. (4870127)
1968
34
Serum proteins in kwashiorkor and marasmus. 2. Non-tuberculous cases and tuberculous cases. (5305683)
1968
35
Experimental kwashiorkor and marasmus. (5722143)
1968
36
Blood urea N and NPN in kwashiorkor and marasmus. (5981458)
1966
37
Kwashiorkor and marasmus. Blood sugar levels and response to epinephrine. (5846687)
1965
38
STUDIES ON CREATININE METABOLISM IN KWASHIORKOR AND MARASMUS. (14286801)
1965
39
Nutritional marasmus in Bantu infants in the Pretoria area. II. Clinical and pathological aspects. (5829053)
1965
40
DIARRHOEA IN KWASHIORKOR AND MARASMUS. (14238715)
1964
41
Serum vitamin B12 concentrations in megaloblastic anemia associated with kwashiorkor and marasmus. (13859314)
1962
42
Marasmus: treatment with whole milk as compared to skimed milk. (14020395)
1962
43
Serum vitamin B12 and folic acid (P.G.A.) levels in hypoproteinaemia and marasmus in Indian children. (14497468)
1962
44
Serum vitamin B12 concentrations in kwashiorkor and marasmus. (13764755)
1960
45
Marasmus resulting from gastro-intestinal allergy. (13472029)
1957
46
A case of infantile wasting (marasmus). (18921037)
1947
47
Marasmus. (21312453)
1926
48
The Etiology of some Forms of Marasmus in Infancy, its Treatment by Lactic Acid Whole Milk. (20314244)
1922
49
Lactic Acid Milk Feeding in Marasmus. (20314245)
1922
50
On the Atrophic Marasmus of Nurslings (So-Called Hospitalism or Athrepsy of Parrot). (20758462)
1899

Genetic Variations for Marasmus

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Expression for genes affiliated with Marasmus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Marasmus

Search GEO for disease gene expression data for Marasmus.

Pathways for genes affiliated with Marasmus

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12EMD Millipore
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Pathways related to Marasmus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ALB, TF

Compounds for genes affiliated with Marasmus

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Marasmus according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2412.2SHBG
2tamoxifen44 49 28 1113.1LSL
3kp-1019449.8ALB, TF
4Bismuth Subsalicylate119.8ALB, TF
5raloxifene44 28 49 1112.7LSL, GH1
6bismuth44 2410.5ALB, TF
7rosiglitazone44 49 28 11 2413.5LSL, SHBG
8oxandrolone44 1110.4SHBG, GH1, IGFBP3
9anastrozole44 1110.4GH1, IGFBP3, SHBG
10oxcarbazepine44 1110.4SHBG, ALB
11clomiphene citrate449.4SHBG, IGFBP3, GH1
12diazoxide44 59 28 1112.4GH1, IGFBP3, SHBG
13glucose449.3LSL, IGFBP3
14bromocriptine28 44 1111.3SHBG, GH1, IGFBP3
15progestins449.3SHBG, GH1, IGFBP3
16Norethindrone119.2SHBG, ALB
17estrone sulfate44 2410.2IGFBP3, SHBG, ALB
18acth449.2IGFBP3, GH1, LSL
1925-hydroxyvitamin d449.2IGFBP3, SHBG, ALB
20Methyltestosterone119.0SHBG, ALB
21octreotide44 59 28 1112.0GH1, IGFBP3, LSL
22vitamin b12448.9ALB, IGFBP3, SHBG, TF
23calcitriol44 59 11 2411.8ALB, IGFBP3, SHBG, GH1
24metformin44 49 1110.8SHBG, GH1, LSL
25carbamazepine44 49 1110.8SHBG, LSL, IGFBP3
26vitamin d448.7ALB, SHBG, GH1, IGFBP3
27ascorbic acid44 249.7SHBG, TF, IGFBP3, ALB
28valproic acid44 49 11 2411.7ALB, IGFBP3, LSL
29deoxypyridinoline448.6IGFBP3, GH1, LSL, SHBG
30dehydroepiandrosterone sulfate448.6IGFBP3, SHBG, LSL, GH1
31hydrocortisone44 2 59 1111.6LSL, TF, GH1, SHBG
32c-peptide448.6SHBG, GH1, LSL, IGFBP3
33dhea448.6IGFBP3, GH1, LSL, SHBG
34triiodothyronine448.6SHBG, IGFBP3, LSL, GH1
35androstenedione44 249.6LSL, SHBG, IGFBP3, GH1
36glycerol44 11 2410.6IGFBP3, SHBG, GH1, LSL
37carbohydrates448.5IGFBP3, SHBG, TF, LSL
38gnrh448.5IGFBP3, SHBG, GH1, LSL
39methotrexate44 49 1110.3ALB, IGFBP3, GH1, TF, LSL
40epinephrine44 11 2410.2IGFBP3, SHBG, TF, LSL, GH1
41estrone44 28 11 2411.1SHBG, ALB, IGFBP3, GH1, LSL
42alanine448.1ALB, SHBG, LSL, TF, GH1
43progesterone44 59 28 11 2412.0LSL, GH1, SHBG, ANXA6, IGFBP3
44testosterone44 59 11 2411.0LSL, IGFBP3, SHBG, GH1, ALB
45prednisolone44 28 119.7ALB, IGFBP3, LSL, TF, GH1, SHBG
46thyroxine44 248.7IGFBP3, ALB, TF, LSL, SHBG, GH1
47lactate447.7GH1, TF, LSL, IGFBP3, ALB, SHBG
48creatinine447.7GH1, IGFBP3, TF, SHBG, ALB, LSL
49aspartate447.7SHBG, GH1, IGFBP3, LSL, ALB, TF
50cholesterol44 28 11 2410.5LSL, ALB, TF, ANXA6, SHBG, IGFBP3

GO Terms for genes affiliated with Marasmus

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16Gene Ontology
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Cellular components related to Marasmus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1ALB, IGFBP3, SHBG, GH1, TF

Biological processes related to Marasmus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.6IGFBP3, GH1

Products for genes affiliated with Marasmus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Marasmus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet