MCID: MRS001
MIFTS: 47

Marasmus malady

Metabolic diseases category
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Summaries for Marasmus

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Wikipedia:65 Marasmus is a form of severe malnutrition characterized by energy deficiency. A child with marasmus... more...

MalaCards based summary: Marasmus, also known as nutritional marasmus, is related to protein-energy malnutrition and hepatitis. An important gene associated with Marasmus is GH1 (growth hormone 1), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Selected targets of C EBPalpha. The compounds kp-1019 and oxandrolone have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and bone.

Aliases & Classifications for Marasmus

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 27ICD9CM, 34MeSH, 57SNOMED-CT, 25ICD10
See all sources

Marasmus, Aliases & Descriptions:

Name: Marasmus 8 44 62
Nutritional Marasmus 8 62
 
Nutritional Atrophy 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology8 DOID:12328
ICD9CM27 261
MeSH34 D011502
ICD1025 E41

Related Diseases for Marasmus

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Diseases related to Marasmus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1protein-energy malnutrition30.5ALB, LEPQTL1, TF
2hepatitis30.4ALB, TF
3proteinuria30.0ALB, LEPQTL1, TF
4anorexia nervosa29.6GH1, SHBG, LEPQTL1, IGFBP3
5kwashiorkor11.0
6hypoadrenalism10.5GH1
7rabson-mendenhall syndrome10.5IGFBP3
8turner syndrome10.4IGFBP3
9siderosis10.4TF
10laron syndrome10.3GH1, IGFBP3
11acromegaly10.3IGFBP3, GH1
12insulin-like growth factor 1 resistance to10.3IGFBP3, GH1
13idiopathic juvenile osteoporosis10.3GH1, IGFBP3
14dwarfism10.3IGFBP3, GH1
15short bowel syndrome10.2GH1, ALB
16riboflavin deficiency10.2
17mastitis10.2ALB, GH1
18protein-losing enteropathy10.2TF, ALB
19lipoid nephrosis10.2ALB, TF
20prader-willi syndrome10.2LEPQTL1, GH1
21cushing's syndrome10.2GH1, LEPQTL1
22cork-handlers' disease10.2ALB, TF
23keratomalacia10.1
24primary hyperoxaluria10.1ALB, TF
25growth hormone deficiency10.1IGFBP3, LEPQTL1, GH1
26anovulation10.1IGFBP3, SHBG
27hyperprolactinemia10.1GH1, SHBG
28premature ovarian failure10.1SHBG, IGFBP3
29hypoglycemia10.1IGFBP3, LEPQTL1, GH1
30nutritional deficiency disease10.1TF, IGFBP3, ALB
31nephrotic syndrome10.0ALB, TF
32hepatitis c10.0LEPQTL1, TF
33non-suppurative otitis media10.0TF, SHBG
34gestational diabetes10.0SHBG, LEPQTL1
35alcoholic liver cirrhosis10.0TF, LEPQTL1, ALB
36uterine fibroid10.0SHBG, LEPQTL1
37fatty liver disease10.0LEPQTL1, TF
38liver disease10.0
39pure red-cell aplasia10.0
40peliosis hepatis10.0
41megaloblastic anemia10.0
42shigellosis10.0
43rickets10.0
44cerebritis10.0
45gastroenteritis10.0
46meningitis10.0
47pancreatitis10.0
48pneumonia10.0
49diencephalic syndrome10.0
50deficiency anemia10.0ALB, LEPQTL1, TF

Graphical network of the top 20 diseases related to Marasmus:



Diseases related to marasmus

Symptoms for Marasmus

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Drugs & Therapeutics for Marasmus

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Drug clinical trials:

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Search NIH Clinical Center for Marasmus

Genetic Tests for Marasmus

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Anatomical Context for Marasmus

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MalaCards organs/tissues related to Marasmus:

32
Liver, Testes, Bone, Brain, Cortex, Small intestine, Pancreas, Breast, Adrenal cortex

Animal Models for Marasmus or affiliated genes

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Publications for Marasmus

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Articles related to Marasmus:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test. (24114907)
2013
2
Prenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model. (22558267)
2012
3
Using of WHO guidelines for the management of severe malnutrition to cases of marasmus and kwashiorkor in a Colombia children's hospital. (22072341)
2011
4
Lipid kinetic differences between children with kwashiorkor and those with marasmus. (16762938)
2006
5
Plasma fatty acids in children with grade III protein-energy malnutrition in its different clinical forms: marasmus, marasmic kwashiorkor, and kwashiorkor. (10341499)
1999
6
Whole-body protein kinetics in marasmus and kwashiorkor during acute infection. (9625094)
1998
7
Fatty acid composition of erythrocyte membrane lipid obtained from children suffering from kwashiorkor and marasmus. (2115964)
1990
8
Long-term effects of early kwashiorkor compared with marasmus. I. Physical growth and sexual maturation. (3119811)
1987
9
Screening for marasmus: a discriminant analysis as a guide to choose the anthropometric variables. (3101482)
1987
10
Biochemical aspects of malabsorption in marasmus: effect of dietary rehabilitation. (3939688)
1985
11
Marasmus. (3939295)
1985
12
Marasmus--1985. (3932990)
1985
13
Marasmus in a 17-month-old Laotian: impact of folk beliefs on health. (6420766)
1984
14
Infection and the development of kwashiorkor and marasmus in Africa. (407786)
1977
15
The role of the adrenal cortex in the development of marasmus. (408764)
1977
16
Adrenal cortical function in marasmus. (417998)
1977
17
Metabolic and hormonal responses to a protein-glucose meal in normal infants and in marasmus and marasmic kwashiorkor. (823521)
1976
18
Conduction velocity of motor nerves in children suffering from protein-calorie malnutrition and marasmus. (826388)
1976
19
Decreased interferon production by leukocytes in marasmus. (180790)
1976
20
Studies on kwashiorkor and marasmus in Calcutta (1957-74): III. Therapeutic and follow-up studies. (819366)
1975
21
Cortisol and growth hormone in kwashiorkor and marasmus. (809848)
1975
22
Marasmus and Pneumocystis carinii pneumonia in institutionalised infants. Observations during an endemic. (4213237)
1974
23
Studies on the anaemia of kwashiorkor and marasmus in the Sudan. (4492791)
1973
24
Behavior of infant in causation of nutritional marasmus. (4632066)
1973
25
Jejunal disaccharidase activities in children with marasmus and with kwashiorkor. Response to treatment. (5576036)
1971
26
Immunoglobulins in marasmus. (4099453)
1970
27
Serm proteins in kwashiorkor and marasmus. 5. Correlations between hypoproteinaemia and anaemia, oedema and mortality. (5401894)
1969
28
Serum proteins in kwashiorkor and marasmus. 4. Cases with or without keratomalacia. (5401879)
1969
29
The concentration of copper, zinc and manganese in the liver of African children with marasmus and kwashiorkor. (5786622)
1969
30
Fat balance studies in marasmus. (5374759)
1969
31
Serum proteins in kwashiorkor and marasmus: 3. Non-diarrhoeic and diarrhoeic cases. (5731043)
1968
32
Treatment of severe kwashiorkor and marasmus in hospital. (5681577)
1968
33
Haemorrhagic manifestations in kwashiorkor and marasmus. (5306031)
1967
34
Kwashiorkor and marasmus. Blood sugar levels and response to epinephrine. (5846687)
1965
35
TOTAL BODY-POTASSIUM IN KWASHIORKOR AND MARASMUS. (14337823)
1965
36
STUDIES ON CREATININE METABOLISM IN KWASHIORKOR AND MARASMUS. (14286801)
1965
37
VACUOLISATION OF EARLY ERYTHROBLASTS IN RIBOFLAVINE-DEFICIENT BABOONS AND IN MARASMUS AND KWASHIORKOR. (14213578)
1964
38
KERATOMALACIA IN KWASHIORKOR AND MARASMUS. (14281021)
1964
39
MARASMUS IN SOUTH AFRICAN BANTU CHILDREN. (14045805)
1963
40
Cali-Harvard nutrition project. II. The erythroid atrophy of kwashiorkor and marasmus. (13947506)
1963
41
Red-cell aplasia in marasmus and kwashiorkor. (14458154)
1962
42
Aetiological investigations in kwashiorkor and marasmus. II. Study of socio-economic aspects. (13968005)
1962
43
Pure red-cell aplasia in marasmus and kwashiorkor treated with riboflavine. (13701132)
1961
44
Electrophoretic pattern of plasma proteins in clinically diagnosed cases of kwashiorkor (protein malnutrition) and undernutrition (marasmus) among Ceylonese children. (13796495)
1959
45
Treatment in pediatric practice; management of marasmus. (13620322)
1958
46
Protein requirements of infants; marasmus. (15409286)
1949
47
A case of infantile wasting (marasmus). (18921037)
1947
48
Marasmus. (21312453)
1926
49
The Etiology of some Forms of Marasmus in Infancy, its Treatment by Lactic Acid Whole Milk. (20314244)
1922
50
On the Atrophic Marasmus of Nurslings (So-Called Hospitalism or Athrepsy of Parrot). (20758462)
1899

Variations for Marasmus

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Expression for genes affiliated with Marasmus

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Expression patterns in normal tissues for genes affiliated with Marasmus

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Pathways for genes affiliated with Marasmus

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Pathways related to Marasmus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5ALB, TF
29.5ALB, TF

Compounds for genes affiliated with Marasmus

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Compounds related to Marasmus according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1kp-1019449.8ALB, TF
2oxandrolone44 1110.5GH1, IGFBP3, SHBG
3anastrozole44 50 1111.4IGFBP3, SHBG, GH1
4clomiphene citrate449.4IGFBP3, GH1, SHBG
5diazoxide44 61 28 1112.4IGFBP3, SHBG, GH1
6bromocriptine44 28 1111.3SHBG, GH1, IGFBP3
7octreotide44 61 28 1112.3LEPQTL1, GH1, IGFBP3
8progestins449.3SHBG, GH1, IGFBP3
9estrone sulfate44 2410.2IGFBP3, ALB, SHBG
1025-hydroxyvitamin d449.2ALB, IGFBP3, SHBG
11procollagen449.2GH1, LEPQTL1, IGFBP3
12carbamazepine44 50 1111.1SHBG, LEPQTL1, IGFBP3
13alpha tocopherol449.1TF, IGFBP3, ALB
14metformin44 50 1111.0SHBG, GH1, LEPQTL1
15deoxypyridinoline449.0GH1, SHBG, LEPQTL1, IGFBP3
16dehydroepiandrosterone sulfate449.0GH1, SHBG, LEPQTL1, IGFBP3
17raloxifene44 50 28 1112.0LEPQTL1, GH1, SHBG, IGFBP3
18c-peptide449.0LEPQTL1, SHBG, GH1, IGFBP3
19dhea449.0SHBG, LEPQTL1, IGFBP3, GH1
20triiodothyronine448.9LEPQTL1, GH1, IGFBP3, SHBG
21androstenedione44 249.9LEPQTL1, IGFBP3, SHBG, GH1
22glycerol44 24 1110.9IGFBP3, SHBG, LEPQTL1, GH1
23acth448.9SHBG, LEPQTL1, GH1, IGFBP3
24hydrocortisone44 2 61 1111.9TF, LEPQTL1, SHBG, GH1
25calcitriol44 61 24 1111.9SHBG, IGFBP3, GH1, ALB
26vitamin b12448.9TF, IGFBP3, SHBG, ALB
27gnrh448.9IGFBP3, LEPQTL1, SHBG, GH1
28carbohydrates448.8SHBG, IGFBP3, TF, LEPQTL1
29vitamin d448.8ALB, GH1, IGFBP3, SHBG
30ascorbic acid44 249.7SHBG, IGFBP3, TF, ALB
31valproic acid44 50 24 1111.7LEPQTL1, IGFBP3, ALB
32methotrexate50 44 1110.6LEPQTL1, ALB, TF, GH1, IGFBP3
33epinephrine44 24 1110.5GH1, LEPQTL1, IGFBP3, TF, SHBG
34tamoxifen44 50 28 1111.5SHBG, LEPQTL1, TF, IGFBP3, GH1
35norepinephrine44 24 1110.5SHBG, GH1, LEPQTL1, IGFBP3, TF
36estrone44 28 24 1111.5LEPQTL1, GH1, IGFBP3, ALB, SHBG
37rosiglitazone28 44 50 24 1112.5IGFBP3, LEPQTL1, SHBG, GH1, ALB
38estradiol44 24 1110.4GH1, IGFBP3, LEPQTL1, SHBG, ALB
39testosterone44 61 24 1111.4LEPQTL1, GH1, IGFBP3, ALB, SHBG
40estrogen448.3GH1, SHBG, LEPQTL1, IGFBP3, TF
41glucose448.1ALB, GH1, SHBG, LEPQTL1, IGFBP3
42progesterone44 28 61 24 1112.1IGFBP3, GH1, SHBG, LEPQTL1, ANXA6
43prednisolone44 28 1110.0LEPQTL1, TF, IGFBP3, GH1, ALB, SHBG
44thyroxine44 249.0ALB, GH1, IGFBP3, TF, SHBG, LEPQTL1
45lactate448.0ALB, SHBG, LEPQTL1, GH1, TF, IGFBP3
46creatinine448.0SHBG, TF, GH1, ALB, LEPQTL1, IGFBP3
47aspartate448.0IGFBP3, TF, SHBG, GH1, ALB, LEPQTL1
48alanine448.0TF, LEPQTL1, SHBG, GH1, ALB, IGFBP3
49cholesterol44 28 24 1110.6LEPQTL1, SHBG, TF, ALB, IGFBP3, ANXA6
50lipid447.5ALB, GH1, ANXA6, SHBG, LEPQTL1

GO Terms for genes affiliated with Marasmus

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Cellular components related to Marasmus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7ALB, GH1, IGFBP3, TF
2extracellular regionGO:0055767.8ALB, GH1, SHBG, IGFBP3, TF

Biological processes related to Marasmus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.6GH1, IGFBP3
2platelet degranulationGO:0025769.5ALB, TF
3retina homeostasisGO:0018959.2ALB, TF

Products for genes affiliated with Marasmus

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Sources for Marasmus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet