MCID: MRS001
MIFTS: 36

Marasmus malady

Categories: Metabolic diseases

Aliases & Classifications for Marasmus

Aliases & Descriptions for Marasmus:

Name: Marasmus 12 52 14 69
Nutritional Marasmus 12
Nutritional Atrophy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12328
ICD10 33 E41
ICD9CM 35 261
MeSH 42 D011502
UMLS 69 C0086588

Summaries for Marasmus

MalaCards based summary : Marasmus, also known as nutritional marasmus, is related to kwashiorkor and aquagenic syringeal acrokeratoderm. An important gene associated with Marasmus is ALB (Albumin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Antioxidants and alanine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and bone.

Wikipedia : 71 Marasmus is a form of severe malnutrition characterized by energy deficiency. A child with marasmus... more...

Related Diseases for Marasmus

Diseases related to Marasmus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
id Related Disease Score Top Affiliating Genes
1 kwashiorkor 11.3
2 aquagenic syringeal acrokeratoderm 10.8
3 basal ganglia cerebrovascular disease 10.2 ALB SHBG
4 atopic dermatitis 6 10.2 ALB CD79A
5 colloid adenoma 10.2 ALB CD79A
6 schneiderian carcinoma 10.2 ALB CD79A
7 cerebral sarcoidosis 10.2 ALB TF
8 striatonigral degeneration 10.2 ALB CD79A
9 infertility due to extratesticular cause 10.2 ALB CD79A
10 congenital nystagmus 10.2 ALB CD79A
11 whipple disease 10.2 ALB TF
12 tarp syndrome 10.2 ALB CD79A
13 acute cervicitis 10.2 ALB CD79A
14 ciliary discoordination, due to random ciliary orientation 10.2 ALB CD79A
15 angiokeratoma 10.2 ALB CD79A
16 congenital articular rigidity 10.2 IGFBP3 SHBG
17 venezuelan equine encephalitis 10.2 ALB CD79A
18 dermatomycosis 10.2 ALB CD79A
19 mikulicz disease 10.1 ALB CD79A
20 hypogonadism cardiomyopathy 10.1 GH1 SHBG
21 hemiplegia 10.1 ALB CD79A
22 bronchiolitis 10.1 ALB CD79A
23 autonomic peripheral neuropathy 10.1 ALB CD79A
24 congenital intrinsic factor deficiency 10.1 CD79A TF
25 early yaws 10.1 ALB CD79A
26 anal fistula 10.1 ALB TF
27 central nervous system origin vertigo 10.1 CD79A TF
28 choreatic disease 10.1 ALB CD79A
29 microtia, hearing impairment, and cleft palate 10.1 GH1 IGFBP3
30 spondylometaphyseal dysplasia, megarbane-dagher-melike type 10.1 GH1 IGFBP3
31 breast apocrine carcinoma in situ 10.1 ALB CD79A
32 epileptic encephalopathy, early infantile, 24 10.1 GH1 IGFBP3
33 protein s deficiency 10.1 GH1 IGFBP3
34 phaeochromocytoma 10.1 ALB TTR
35 ehlers-danlos syndrome, periodontal type 1 10.1 ALB TTR
36 inner ear disease 10.1 ALB TTR
37 cataract 10.1 ALB TTR
38 capillary lymphangioma 10.1 GH1 SHBG
39 congenital nonspherocytic hemolytic anemia 10.1 ALB TTR
40 erythema infectiosum 10.0 ALB TTR
41 mixed germ cell-sex cord neoplasm 10.0 ALB CD79A
42 peripheral vascular disease 10.0 ALB TTR
43 choriodal dystrophy, central areolar 2 10.0 TF TTR
44 bacteriuria 10.0 TF TTR
45 hemopericardium 10.0 ALB TTR
46 gynandroblastoma 10.0 GH1 IGFBP3
47 auditory neuropathy, autosomal dominant, 1 10.0 ALB TF
48 anterior foramen magnum meningioma 10.0 ALB CD79A
49 acute female pelvic peritonitis 10.0 CD79A TTR
50 coronary artery dissection, spontaneous 10.0 ALB CD79A TF

Comorbidity relations with Marasmus via Phenotypic Disease Network (PDN): (show all 21)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Bronchitis Chronic Kidney Failure
Decubitus Ulcer Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Heart Disease Intestinal Obstruction
Iron Deficiency Anemia Osteoporosis
Paralytic Ileus Parkinson Disease, Late-Onset
Postinflammatory Pulmonary Fibrosis Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Swallowing Disorders

Graphical network of the top 20 diseases related to Marasmus:



Diseases related to Marasmus

Symptoms & Phenotypes for Marasmus

Drugs & Therapeutics for Marasmus

Drugs for Marasmus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antioxidants Phase 1
2 alanine Nutraceutical Phase 1
3 cysteine Nutraceutical Phase 1
4
Lamivudine Approved, Investigational 134678-17-4 60825
5
Nevirapine Approved 129618-40-2 4463
6
Zidovudine Approved 30516-87-1 35370
7
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
8
Cefdinir Approved 91832-40-5 6915944
9
Ethanol Approved 64-17-5 702
10 Anti-HIV Agents
11 Anti-Infective Agents
12 Antimetabolites
13 Anti-Retroviral Agents
14 Antiviral Agents
15 Cytochrome P-450 CYP3A Inducers
16 Nucleic Acid Synthesis Inhibitors
17 Reverse Transcriptase Inhibitors
18 Anti-Bacterial Agents
19 Antibiotics, Antitubercular
20 Anticholesteremic Agents
21 Anti-Infective Agents, Local
22 Central Nervous System Depressants
23 Hydroxymethylglutaryl-CoA Reductase Inhibitors
24 Hypolipidemic Agents
25 Lipid Regulating Agents
26 Platelet Aggregation Inhibitors
27 policosanol
28 Disinfectants

Interventional clinical trials:


id Name Status NCT ID Phase
1 Study of Antioxidants and Oxidants in Malnourished Children Unknown status NCT00069134 Phase 1
2 Developmental Adaptation to an Obesogenic Environment Completed NCT02257593
3 Safety and Metabolic Study of Highly Active Antiretroviral Therapy (HAART) in Malnourished Children With HIV Completed NCT01529125
4 Pilot Study of PUFA-optimized RUTF for Severe Acute Malnutrition Completed NCT02053857
5 Effectiveness of Oral Antibiotics in the Treatment of Severe Acute Malnutrition Completed NCT01000298
6 Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers Completed NCT01790815
7 Characterizing the Gut Microbiota Alteration Associated With Severe Acute Malnutrition Completed NCT02413905
8 Effect of Policosanol as Monotherapy and Adjunctive to Statin Therapy Completed NCT00510809
9 Effectiveness of Safe Drinking Water in Treatment of Severe Acute Malnutrition (Pakistan) Active, not recruiting NCT02751476
10 Effectiveness of Oral Albendazole in the Treatment of Severe Acute Malnutrition Withdrawn NCT01395381

Search NIH Clinical Center for Marasmus

Genetic Tests for Marasmus

Anatomical Context for Marasmus

MalaCards organs/tissues related to Marasmus:

39
Liver, Testes, Bone, Breast, Pancreas, Cortex, Adrenal Cortex

Publications for Marasmus

Articles related to Marasmus:

(show top 50) (show all 197)
id Title Authors Year
1
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test. ( 24114907 )
2013
2
Prenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model. ( 22558267 )
2012
3
Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic I^-cell dysfunction. ( 22386944 )
2012
4
Acute liver injury with severe coagulopathy in marasmus caused by a somatic delusional disorder. ( 25954537 )
2011
5
Using of WHO guidelines for the management of severe malnutrition to cases of marasmus and kwashiorkor in a Colombia children's hospital. ( 22072341 )
2011
6
INCAP studies of kwashiorkor and marasmus. ( 20461902 )
2010
7
Reduced production of sulfated glycosaminoglycans occurs in Zambian children with kwashiorkor but not marasmus. ( 19116330 )
2009
8
The quality of the diet in Malawian children with kwashiorkor and marasmus. ( 16881921 )
2006
9
Lipid kinetic differences between children with kwashiorkor and those with marasmus. ( 16762938 )
2006
10
Serum concentrations of sex hormone binding globulin are elevated in kwashiorkor and anorexia nervosa but not in marasmus. ( 12081841 )
2002
11
Plasma fatty acids in children with grade III protein-energy malnutrition in its different clinical forms: marasmus, marasmic kwashiorkor, and kwashiorkor. ( 10341499 )
1999
12
Ready-to-use therapeutic food for treatment of marasmus. ( 10347999 )
1999
13
Lipids, lipoproteins, and fatty acids during infantile marasmus in the FA"s area of Morocco. ( 10424250 )
1999
14
Whole-body protein kinetics in marasmus and kwashiorkor during acute infection. ( 9625094 )
1998
15
Plasma concentration of taurine is higher in malnourished than control children: differences between kwashiorkor and marasmus. ( 9635065 )
1998
16
Protein-energy malnutrition (kwashiorkor and marasmus). ( 8699299 )
1996
17
Red blood cell antioxidant enzyme concentrations in kwashiorkor and marasmus. ( 7681643 )
1993
18
Risk factors for clinical marasmus: a case-control study of Bangladeshi children. ( 8505185 )
1993
19
The exocrine pancreas in kwashiorkor and marasmus. Light and electron microscopy. ( 1523833 )
1992
20
Kwashiorkor and marasmus: evolution and distinguishing features. 1968. ( 1306670 )
1992
21
Traditional perceptions of marasmus in Pakistan. ( 1901666 )
1991
22
Kwashiorkor-marasmus syndrome and nutritional rickets--a bone biopsy study. ( 1781011 )
1991
23
Kwashiorkor and marasmus: changing hospital incidence of syndromic presentation (1957-88). ( 2127923 )
1990
24
Fatty acid composition of erythrocyte membrane lipid obtained from children suffering from kwashiorkor and marasmus. ( 2115964 )
1990
25
The long-term effects of early kwashiorkor compared with marasmus. IV. Performance on the national high school entrance examination. ( 2122403 )
1990
26
Mild-moderate Kwashiorkor-Marasmus syndrome: anthropometric and biochemical observations. ( 2518626 )
1989
27
Peliosis hepatis in a patient with marasmus. ( 3135227 )
1988
28
Long-term effects of early kwashiorkor compared with marasmus. I. Physical growth and sexual maturation. ( 3119811 )
1987
29
Famine in Ethiopia 1983-1985: kwashiorkor and marasmus in four regions. ( 2438995 )
1987
30
Screening for marasmus: a discriminant analysis as a guide to choose the anthropometric variables. ( 3101482 )
1987
31
Long-term effects of early kwashiorkor compared with marasmus. II. Intellectual performance. ( 3119812 )
1987
32
Long-term effects of early kwashiorkor compared with marasmus. III. Fine motor skills. ( 3119813 )
1987
33
Protein-energy malnutrition (Kwashiorkor-Marasmus syndrome): terminology, classification and evolution. ( 3088855 )
1986
34
Severe undernutrition in Jamaica. Kwashiorkor and marasmus: the disease of the weanling. ( 3092564 )
1986
35
Serum lipids in marasmus. ( 3934072 )
1985
36
Marasmus. ( 3939295 )
1985
37
Biochemical aspects of malabsorption in marasmus: effect of dietary rehabilitation. ( 3939688 )
1985
38
Marasmus--1985. ( 3932990 )
1985
39
Calcium metabolism in marasmus. ( 6442922 )
1984
40
Biochemical aspects of malabsorption in marasmus. ( 6418198 )
1984
41
Marasmus in a 17-month-old Laotian: impact of folk beliefs on health. ( 6420766 )
1984
42
Controlled trial of copper supplementation during the recovery from marasmus. ( 6405607 )
1983
43
Gastric function in marasmus. ( 6427107 )
1983
44
Growth of Nigerian children with marasmus after hospital treatment. ( 6402601 )
1983
45
Intestinal bypass in the rat: a model for growth failure, liver disease, and jejunal bacterial overgrowth in marasmus and kwashiorkor. ( 6821113 )
1982
46
Gastric mucosal functions and histology in marasmus. ( 6819226 )
1982
47
Urinary catecholamine in kwashiorkor and marasmus. ( 6819336 )
1982
48
Leucocyte protein and free alpha amino nitrogen levels in marasmus. ( 6796513 )
1981
49
Beetle marasmus. ( 6794839 )
1981
50
Plasma amino acid ratios in Nigerian children suffering from marasmus and kwashiorkor. ( 6796379 )
1981

Variations for Marasmus

Expression for Marasmus

Search GEO for disease gene expression data for Marasmus.

Pathways for Marasmus

Pathways related to Marasmus according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.27 ALB TTR

GO Terms for Marasmus

Cellular components related to Marasmus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ALB GH1 IGFBP3 TF TTR
2 endoplasmic reticulum lumen GO:0005788 9.33 ALB IGFBP3 TF
3 extracellular region GO:0005576 9.1 ALB GH1 IGFBP3 SHBG TF TTR

Biological processes related to Marasmus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.43 ALB IGFBP3 TF
2 retina homeostasis GO:0001895 9.16 ALB TF
3 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.96 GH1 IGFBP3
4 cellular protein metabolic process GO:0044267 8.92 ALB IGFBP3 TF TTR

Sources for Marasmus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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