Aliases & Classifications for Marasmus

MalaCards integrated aliases for Marasmus:

Name: Marasmus 12 51 14 69
Nutritional Marasmus 12
Nutritional Atrophy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12328
ICD10 32 E41
ICD9CM 34 261
MeSH 41 D011502
UMLS 69 C0086588

Summaries for Marasmus

MalaCards based summary : Marasmus, also known as nutritional marasmus, is related to kwashiorkor and pure red-cell aplasia. An important gene associated with Marasmus is ALB (Albumin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Lamivudine and Nevirapine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and pancreas.

Wikipedia : 72 Marasmus is a form of severe malnutrition characterized by protein deficiency. It can occur in anyone... more...

Related Diseases for Marasmus

Diseases related to Marasmus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 kwashiorkor 31.3 ALB SHBG TF TTR
2 pure red-cell aplasia 30.0 ALB TF
3 keratomalacia 29.8 TF TTR
4 shigellosis 29.4 CD79A TTR
5 protein-energy malnutrition 29.1 ALB CD79A TF TTR
6 aquagenic syringeal acrokeratoderm 10.9
7 fetal erythroblastosis 10.3 ALB SHBG
8 47, xxy 10.3 IGFBP3 SHBG
9 ariboflavinosis 10.3 ALB TF
10 cork-handlers' disease 10.3 ALB CD79A
11 ostertagiasis 10.3 ALB CD79A
12 dermatitis, atopic, 3 10.3 ALB CD79A
13 orthostatic proteinuria 10.3 ALB CD79A
14 root caries 10.2 ALB CD79A
15 complete androgen insensitivity syndrome 10.2 IGFBP3 SHBG
16 parotitis 10.2 ALB CD79A
17 chronic graft versus host disease 10.2 ALB CD79A
18 diffuse glomerulonephritis 10.2 ALB CD79A
19 focal dermal hypoplasia 10.2 ALB CD79A
20 non-secretory myeloma 10.2 ALB CD79A
21 hypersensitivity reaction type iii disease 10.2 ALB CD79A
22 protein-losing enteropathy 10.2 ALB CD79A
23 alcoholic liver cirrhosis 10.2 ALB TF
24 ulcerative stomatitis 10.2 ALB CD79A
25 pneumocystosis 10.2 ALB CD79A
26 autoimmune disease of urogenital tract 10.2 ALB CD79A
27 hypoadrenalism 10.2 GH1 SHBG
28 meningoencephalitis 10.2 ALB CD79A
29 keratoconjunctivitis sicca 10.2 ALB CD79A
30 membranoproliferative glomerulonephritis 10.2 ALB CD79A
31 guillain-barre syndrome 10.2 ALB CD79A
32 male reproductive organ cancer 10.2 IGFBP3 SHBG
33 vitamin b12 deficiency 10.2 CD79A TF
34 extrinsic allergic alveolitis 10.2 ALB CD79A
35 wilson disease 10.2 ALB TF
36 primary bacterial infectious disease 10.2 ALB CD79A
37 membranous nephropathy 10.1 ALB CD79A
38 vernal conjunctivitis 10.1 CD79A TF
39 intestinal disease 10.1 ALB CD79A
40 hypersensitivity reaction disease 10.1 ALB CD79A
41 gonadal disease 10.1 GH1 SHBG
42 uremia 10.1 ALB TF
43 schistosomiasis 10.1 ALB CD79A
44 bronchitis 10.1 ALB CD79A
45 gastroduodenitis 10.1 CD79A GH1
46 pituitary adenoma 1, multiple types 10.1 GH1 IGFBP3
47 otitis media 10.1 ALB CD79A
48 trypanosomiasis 10.1 ALB TF
49 breast disease 10.1 IGFBP3 SHBG
50 hyperpituitarism 10.1 GH1 IGFBP3

Comorbidity relations with Marasmus via Phenotypic Disease Network (PDN): (show all 21)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Bronchitis Chronic Kidney Failure
Decubitus Ulcer Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Heart Disease Intestinal Obstruction
Iron Deficiency Anemia Osteoporosis
Paralytic Ileus Parkinson Disease, Late-Onset
Postinflammatory Pulmonary Fibrosis Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Swallowing Disorders

Graphical network of the top 20 diseases related to Marasmus:



Diseases related to Marasmus

Symptoms & Phenotypes for Marasmus

Drugs & Therapeutics for Marasmus

Drugs for Marasmus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamivudine Approved, Investigational 134678-17-4 60825
2
Nevirapine Approved 129618-40-2 4463
3
Zidovudine Approved 30516-87-1 35370
4
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
5
Cefdinir Approved 91832-40-5 6915944
6
Ethanol Approved 64-17-5 702
7 Anti-HIV Agents
8 Anti-Infective Agents
9 Antimetabolites
10 Antioxidants
11 Anti-Retroviral Agents
12 Antiviral Agents
13 Cytochrome P-450 CYP3A Inducers
14 Nucleic Acid Synthesis Inhibitors
15 Reverse Transcriptase Inhibitors
16 Anti-Bacterial Agents
17 Antibiotics, Antitubercular
18 Anticholesteremic Agents
19 Anti-Infective Agents, Local
20 Central Nervous System Depressants
21 Hydroxymethylglutaryl-CoA Reductase Inhibitors
22 Hypolipidemic Agents
23 Lipid Regulating Agents
24 Platelet Aggregation Inhibitors
25 policosanol
26 Disinfectants
27 alanine Nutraceutical
28 cysteine Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Developmental Adaptation to an Obesogenic Environment Completed NCT02257593
2 Safety and Metabolic Study of Highly Active Antiretroviral Therapy (HAART) in Malnourished Children With HIV Completed NCT01529125 zidovudine, lamivudine, nevirapine
3 Pilot Study of PUFA-optimized RUTF for Severe Acute Malnutrition Completed NCT02053857 Amoxicillin
4 Effectiveness of Oral Antibiotics in the Treatment of Severe Acute Malnutrition Completed NCT01000298 Placebo;Amoxicillin;Cefdinir
5 Study of Antioxidants and Oxidants in Malnourished Children Completed NCT00069134
6 Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers Completed NCT01790815
7 Characterizing the Gut Microbiota Alteration Associated With Severe Acute Malnutrition Completed NCT02413905
8 Effect of Policosanol as Monotherapy and Adjunctive to Statin Therapy Completed NCT00510809 Policosanol;Policosanol Plus Already In Use Statin Therapy
9 Effectiveness of Safe Drinking Water in Treatment of Severe Acute Malnutrition (Pakistan) Active, not recruiting NCT02751476
10 Effectiveness of Oral Albendazole in the Treatment of Severe Acute Malnutrition Withdrawn NCT01395381 Placebo;Albendazole

Search NIH Clinical Center for Marasmus

Genetic Tests for Marasmus

Anatomical Context for Marasmus

MalaCards organs/tissues related to Marasmus:

38
Liver, Testes, Pancreas, Adrenal Cortex, Small Intestine, Brain, Cortex

Publications for Marasmus

Articles related to Marasmus:

(show top 50) (show all 197)
# Title Authors Year
1
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test. ( 24114907 )
2013
2
Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic I^-cell dysfunction. ( 22386944 )
2012
3
Prenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model. ( 22558267 )
2012
4
Acute liver injury with severe coagulopathy in marasmus caused by a somatic delusional disorder. ( 25954537 )
2011
5
Using of WHO guidelines for the management of severe malnutrition to cases of marasmus and kwashiorkor in a Colombia children's hospital. ( 22072341 )
2011
6
INCAP studies of kwashiorkor and marasmus. ( 20461902 )
2010
7
Reduced production of sulfated glycosaminoglycans occurs in Zambian children with kwashiorkor but not marasmus. ( 19116330 )
2009
8
Lipid kinetic differences between children with kwashiorkor and those with marasmus. ( 16762938 )
2006
9
The quality of the diet in Malawian children with kwashiorkor and marasmus. ( 16881921 )
2006
10
Serum concentrations of sex hormone binding globulin are elevated in kwashiorkor and anorexia nervosa but not in marasmus. ( 12081841 )
2002
11
Lipids, lipoproteins, and fatty acids during infantile marasmus in the FA"s area of Morocco. ( 10424250 )
1999
12
Plasma fatty acids in children with grade III protein-energy malnutrition in its different clinical forms: marasmus, marasmic kwashiorkor, and kwashiorkor. ( 10341499 )
1999
13
Ready-to-use therapeutic food for treatment of marasmus. ( 10347999 )
1999
14
Whole-body protein kinetics in marasmus and kwashiorkor during acute infection. ( 9625094 )
1998
15
Plasma concentration of taurine is higher in malnourished than control children: differences between kwashiorkor and marasmus. ( 9635065 )
1998
16
Protein-energy malnutrition (kwashiorkor and marasmus). ( 8699299 )
1996
17
Risk factors for clinical marasmus: a case-control study of Bangladeshi children. ( 8505185 )
1993
18
Red blood cell antioxidant enzyme concentrations in kwashiorkor and marasmus. ( 7681643 )
1993
19
Kwashiorkor and marasmus: evolution and distinguishing features. 1968. ( 1306670 )
1992
20
The exocrine pancreas in kwashiorkor and marasmus. Light and electron microscopy. ( 1523833 )
1992
21
Kwashiorkor-marasmus syndrome and nutritional rickets--a bone biopsy study. ( 1781011 )
1991
22
Traditional perceptions of marasmus in Pakistan. ( 1901666 )
1991
23
Kwashiorkor and marasmus: changing hospital incidence of syndromic presentation (1957-88). ( 2127923 )
1990
24
The long-term effects of early kwashiorkor compared with marasmus. IV. Performance on the national high school entrance examination. ( 2122403 )
1990
25
Fatty acid composition of erythrocyte membrane lipid obtained from children suffering from kwashiorkor and marasmus. ( 2115964 )
1990
26
Mild-moderate Kwashiorkor-Marasmus syndrome: anthropometric and biochemical observations. ( 2518626 )
1989
27
Peliosis hepatis in a patient with marasmus. ( 3135227 )
1988
28
Long-term effects of early kwashiorkor compared with marasmus. I. Physical growth and sexual maturation. ( 3119811 )
1987
29
Screening for marasmus: a discriminant analysis as a guide to choose the anthropometric variables. ( 3101482 )
1987
30
Long-term effects of early kwashiorkor compared with marasmus. III. Fine motor skills. ( 3119813 )
1987
31
Famine in Ethiopia 1983-1985: kwashiorkor and marasmus in four regions. ( 2438995 )
1987
32
Long-term effects of early kwashiorkor compared with marasmus. II. Intellectual performance. ( 3119812 )
1987
33
Protein-energy malnutrition (Kwashiorkor-Marasmus syndrome): terminology, classification and evolution. ( 3088855 )
1986
34
Severe undernutrition in Jamaica. Kwashiorkor and marasmus: the disease of the weanling. ( 3092564 )
1986
35
Serum lipids in marasmus. ( 3934072 )
1985
36
Marasmus. ( 3939295 )
1985
37
Biochemical aspects of malabsorption in marasmus: effect of dietary rehabilitation. ( 3939688 )
1985
38
Marasmus--1985. ( 3932990 )
1985
39
Marasmus in a 17-month-old Laotian: impact of folk beliefs on health. ( 6420766 )
1984
40
Calcium metabolism in marasmus. ( 6442922 )
1984
41
Biochemical aspects of malabsorption in marasmus. ( 6418198 )
1984
42
Growth of Nigerian children with marasmus after hospital treatment. ( 6402601 )
1983
43
Gastric function in marasmus. ( 6427107 )
1983
44
Controlled trial of copper supplementation during the recovery from marasmus. ( 6405607 )
1983
45
Intestinal bypass in the rat: a model for growth failure, liver disease, and jejunal bacterial overgrowth in marasmus and kwashiorkor. ( 6821113 )
1982
46
Gastric mucosal functions and histology in marasmus. ( 6819226 )
1982
47
Urinary catecholamine in kwashiorkor and marasmus. ( 6819336 )
1982
48
Beetle marasmus. ( 6794839 )
1981
49
Intravenous glucose utilization in marasmus. ( 6795112 )
1981
50
Blood plasma levels of cortisol, insulin, growth hormone and somatomedin in children with marasmus, kwashiorkor, and intermediate forms of protein-energy malnutrition. ( 6792631 )
1981

Variations for Marasmus

Expression for Marasmus

Search GEO for disease gene expression data for Marasmus.

Pathways for Marasmus

Pathways related to Marasmus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 ALB TTR

GO Terms for Marasmus

Cellular components related to Marasmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ALB GH1 IGFBP3 TF TTR
2 endoplasmic reticulum lumen GO:0005788 9.33 ALB IGFBP3 TF
3 extracellular region GO:0005576 9.1 ALB GH1 IGFBP3 SHBG TF TTR

Biological processes related to Marasmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.43 ALB IGFBP3 TF
2 retina homeostasis GO:0001895 9.16 ALB TF
3 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.96 GH1 IGFBP3
4 cellular protein metabolic process GO:0044267 8.92 ALB IGFBP3 TF TTR

Sources for Marasmus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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