MCID: MRS001
MIFTS: 40

Marasmus malady

Metabolic diseases category

Summaries for Marasmus

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Wikipedia:63 Marasmus is a form of severe malnutrition characterized by energy deficiency. A child with marasmus... more...

MalaCards based summary: Marasmus, also known as nutritional marasmus, is related to protein-energy malnutrition and hepatitis. An important gene associated with Marasmus is GH1 (growth hormone 1), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Selected targets of C EBPalpha. The compounds kp-1019 and oxandrolone have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and bone.

Aliases & Classifications for Marasmus

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 27ICD9CM, 55SNOMED-CT, 33MeSH, 25ICD10
See all sources

Marasmus, Aliases & Descriptions:

Name: Marasmus 9 43 60
Nutritional Marasmus 9
 
Nutritional Atrophy 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology9 DOID:12328
ICD9CM27 261
MeSH33 D011502
ICD1025 E41

Related Diseases for Marasmus

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Diseases related to Marasmus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1protein-energy malnutrition30.5ALB, LEPQTL1, TF
2hepatitis30.4ALB, TF
3proteinuria30.0ALB, LEPQTL1, TF
4liver disease29.8ALB, TF
5anorexia nervosa29.6GH1, SHBG, LEPQTL1, IGFBP3
6kwashiorkor11.0
7hypoadrenalism10.5GH1
8rabson-mendenhall syndrome10.5IGFBP3
9turner syndrome10.4IGFBP3
10siderosis10.4TF
11laron dwarfism10.3GH1, IGFBP3
12pituitary gigantism10.3IGFBP3, GH1
13insulin-like growth factor 1 resistance to10.3IGFBP3, GH1
14idiopathic juvenile osteoporosis10.3GH1, IGFBP3
15dwarfism10.3IGFBP3, GH1
16riboflavin deficiency10.2
17short bowel syndrome10.2GH1, ALB
18mastitis10.2ALB, GH1
19protein-losing enteropathy10.2TF, ALB
20lipoid nephrosis10.2ALB, TF
21prader-willi syndrome10.2LEPQTL1, GH1
22cushing's syndrome10.2GH1, LEPQTL1
23cork-handlers' disease10.2ALB, TF
24keratomalacia10.1
25oligomenorrhea10.1SHBG, GH1
26prostatic hypertrophy10.1SHBG, GH1
27primary hyperoxaluria10.1ALB, TF
28growth hormone deficiency10.1IGFBP3, LEPQTL1, GH1
29anovulation10.1IGFBP3, SHBG
30hyperprolactinemia10.1GH1, SHBG
31premature ovarian failure10.1SHBG, IGFBP3
32hypoglycemia10.1IGFBP3, LEPQTL1, GH1
33nutritional deficiency disease10.1TF, IGFBP3, ALB
34nephrotic syndrome10.0ALB, TF
35hepatitis c10.0LEPQTL1, TF
36non-suppurative otitis media10.0TF, SHBG
37mody, type ii10.0SHBG, LEPQTL1
38uterine fibroid10.0SHBG, LEPQTL1
39alcoholic liver cirrhosis10.0TF, LEPQTL1, ALB
40pure red-cell aplasia10.0
41peliosis hepatis10.0
42rickets10.0
43cerebritis10.0
44shigellosis10.0
45megaloblastic anemia10.0
46gastroenteritis10.0
47meningitis10.0
48pancreatitis10.0
49pneumonia10.0
50diencephalic syndrome10.0

Graphical network of the top 20 diseases related to Marasmus:



Diseases related to marasmus

Symptoms for Marasmus

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Drugs & Therapeutics for Marasmus

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Drug clinical trials:

Search ClinicalTrials for Marasmus

Search NIH Clinical Center for Marasmus

Genetic Tests for Marasmus

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Anatomical Context for Marasmus

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MalaCards organs/tissues related to Marasmus:

31
Liver, Testes, Bone, Brain, Cortex, Small intestine, Pancreas, Breast, Adrenal cortex

Animal Models for Marasmus or affiliated genes

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Publications for Marasmus

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Articles related to Marasmus:

(show top 50)    (show all 193)
idTitleAuthorsYear
1
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test. (24114907)
2013
2
Prenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model. (22558267)
2012
3
Using of WHO guidelines for the management of severe malnutrition to cases of marasmus and kwashiorkor in a Colombia children's hospital. (22072341)
2011
4
Lipid kinetic differences between children with kwashiorkor and those with marasmus. (16762938)
2006
5
Plasma fatty acids in children with grade III protein-energy malnutrition in its different clinical forms: marasmus, marasmic kwashiorkor, and kwashiorkor. (10341499)
1999
6
Whole-body protein kinetics in marasmus and kwashiorkor during acute infection. (9625094)
1998
7
Fatty acid composition of erythrocyte membrane lipid obtained from children suffering from kwashiorkor and marasmus. (2115964)
1990
8
Long-term effects of early kwashiorkor compared with marasmus. I. Physical growth and sexual maturation. (3119811)
1987
9
Screening for marasmus: a discriminant analysis as a guide to choose the anthropometric variables. (3101482)
1987
10
Biochemical aspects of malabsorption in marasmus: effect of dietary rehabilitation. (3939688)
1985
11
Marasmus. (3939295)
1985
12
Marasmus--1985. (3932990)
1985
13
Marasmus in a 17-month-old Laotian: impact of folk beliefs on health. (6420766)
1984
14
Urinary catecholamine in kwashiorkor and marasmus. (6819336)
1982
15
Infection and the development of kwashiorkor and marasmus in Africa. (407786)
1977
16
The role of the adrenal cortex in the development of marasmus. (408764)
1977
17
Adrenal cortical function in marasmus. (417998)
1977
18
Metabolic and hormonal responses to a protein-glucose meal in normal infants and in marasmus and marasmic kwashiorkor. (823521)
1976
19
Conduction velocity of motor nerves in children suffering from protein-calorie malnutrition and marasmus. (826388)
1976
20
Decreased interferon production by leukocytes in marasmus. (180790)
1976
21
Studies on kwashiorkor and marasmus in Calcutta (1957-74): III. Therapeutic and follow-up studies. (819366)
1975
22
Cortisol and growth hormone in kwashiorkor and marasmus. (809848)
1975
23
Marasmus and Pneumocystis carinii pneumonia in institutionalised infants. Observations during an endemic. (4213237)
1974
24
Studies on the anaemia of kwashiorkor and marasmus in the Sudan. (4492791)
1973
25
Behavior of infant in causation of nutritional marasmus. (4632066)
1973
26
Jejunal disaccharidase activities in children with marasmus and with kwashiorkor. Response to treatment. (5576036)
1971
27
Serm proteins in kwashiorkor and marasmus. 5. Correlations between hypoproteinaemia and anaemia, oedema and mortality. (5401894)
1969
28
Serum proteins in kwashiorkor and marasmus. 4. Cases with or without keratomalacia. (5401879)
1969
29
The concentration of copper, zinc and manganese in the liver of African children with marasmus and kwashiorkor. (5786622)
1969
30
Fat balance studies in marasmus. (5374759)
1969
31
Serum proteins in kwashiorkor and marasmus: 3. Non-diarrhoeic and diarrhoeic cases. (5731043)
1968
32
Treatment of severe kwashiorkor and marasmus in hospital. (5681577)
1968
33
Haemorrhagic manifestations in kwashiorkor and marasmus. (5306031)
1967
34
Kwashiorkor and marasmus. Blood sugar levels and response to epinephrine. (5846687)
1965
35
TOTAL BODY-POTASSIUM IN KWASHIORKOR AND MARASMUS. (14337823)
1965
36
STUDIES ON CREATININE METABOLISM IN KWASHIORKOR AND MARASMUS. (14286801)
1965
37
VACUOLISATION OF EARLY ERYTHROBLASTS IN RIBOFLAVINE-DEFICIENT BABOONS AND IN MARASMUS AND KWASHIORKOR. (14213578)
1964
38
KERATOMALACIA IN KWASHIORKOR AND MARASMUS. (14281021)
1964
39
MARASMUS IN SOUTH AFRICAN BANTU CHILDREN. (14045805)
1963
40
Cali-Harvard nutrition project. II. The erythroid atrophy of kwashiorkor and marasmus. (13947506)
1963
41
Red-cell aplasia in marasmus and kwashiorkor. (14458154)
1962
42
Aetiological investigations in kwashiorkor and marasmus. II. Study of socio-economic aspects. (13968005)
1962
43
Pure red-cell aplasia in marasmus and kwashiorkor treated with riboflavine. (13701132)
1961
44
Electrophoretic pattern of plasma proteins in clinically diagnosed cases of kwashiorkor (protein malnutrition) and undernutrition (marasmus) among Ceylonese children. (13796495)
1959
45
Treatment in pediatric practice; management of marasmus. (13620322)
1958
46
Protein requirements of infants; marasmus. (15409286)
1949
47
A case of infantile wasting (marasmus). (18921037)
1947
48
Marasmus. (21312453)
1926
49
The Etiology of some Forms of Marasmus in Infancy, its Treatment by Lactic Acid Whole Milk. (20314244)
1922
50
On the Atrophic Marasmus of Nurslings (So-Called Hospitalism or Athrepsy of Parrot). (20758462)
1899

Variations for Marasmus

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Expression for genes affiliated with Marasmus

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Search GEO for disease gene expression data for Marasmus.

Pathways for genes affiliated with Marasmus

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Pathways related to Marasmus according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5ALB, TF

Compounds for genes affiliated with Marasmus

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Compounds related to Marasmus according to GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1kp-1019439.8ALB, TF
2oxandrolone43 1210.5GH1, IGFBP3, SHBG
3anastrozole43 49 1211.4IGFBP3, SHBG, GH1
4clomiphene citrate439.4IGFBP3, GH1, SHBG
5diazoxide43 59 28 1212.4IGFBP3, SHBG, GH1
6bromocriptine43 28 1211.3SHBG, GH1, IGFBP3
7octreotide43 59 28 1212.3LEPQTL1, GH1, IGFBP3
8progestins439.3SHBG, GH1, IGFBP3
9estrone sulfate43 2410.2IGFBP3, ALB, SHBG
1025-hydroxyvitamin d439.2ALB, IGFBP3, SHBG
11procollagen439.2GH1, LEPQTL1, IGFBP3
12carbamazepine43 49 1211.1SHBG, LEPQTL1, IGFBP3
13alpha tocopherol439.1TF, IGFBP3, ALB
14metformin43 49 1211.0SHBG, GH1, LEPQTL1
15deoxypyridinoline439.0GH1, SHBG, LEPQTL1, IGFBP3
16dehydroepiandrosterone sulfate439.0GH1, SHBG, LEPQTL1, IGFBP3
17raloxifene43 49 28 1212.0LEPQTL1, GH1, SHBG, IGFBP3
18c-peptide439.0LEPQTL1, SHBG, GH1, IGFBP3
19dhea439.0SHBG, LEPQTL1, IGFBP3, GH1
20triiodothyronine438.9LEPQTL1, GH1, IGFBP3, SHBG
21androstenedione43 249.9LEPQTL1, IGFBP3, SHBG, GH1
22glycerol43 24 1210.9IGFBP3, SHBG, LEPQTL1, GH1
23acth438.9SHBG, LEPQTL1, GH1, IGFBP3
24hydrocortisone43 2 59 1211.9TF, LEPQTL1, SHBG, GH1
25calcitriol43 59 24 1211.9SHBG, IGFBP3, GH1, ALB
26vitamin b12438.9TF, IGFBP3, SHBG, ALB
27gnrh438.9IGFBP3, LEPQTL1, SHBG, GH1
28carbohydrates438.8SHBG, IGFBP3, TF, LEPQTL1
29vitamin d438.8ALB, GH1, IGFBP3, SHBG
30ascorbic acid43 249.7SHBG, IGFBP3, TF, ALB
31valproic acid43 49 24 1211.7LEPQTL1, IGFBP3, ALB
32methotrexate49 43 1210.6LEPQTL1, ALB, TF, GH1, IGFBP3
33epinephrine43 24 1210.5GH1, LEPQTL1, IGFBP3, TF, SHBG
34tamoxifen43 49 28 1211.5SHBG, LEPQTL1, TF, IGFBP3, GH1
35norepinephrine43 24 1210.5SHBG, GH1, LEPQTL1, IGFBP3, TF
36estrone43 28 24 1211.5LEPQTL1, GH1, IGFBP3, ALB, SHBG
37rosiglitazone28 43 49 24 1212.5IGFBP3, LEPQTL1, SHBG, GH1, ALB
38estradiol43 24 1210.4GH1, IGFBP3, LEPQTL1, SHBG, ALB
39testosterone43 59 24 1211.4LEPQTL1, GH1, IGFBP3, ALB, SHBG
40estrogen438.3GH1, SHBG, LEPQTL1, IGFBP3, TF
41glucose438.1ALB, GH1, SHBG, LEPQTL1, IGFBP3
42progesterone43 28 59 24 1212.1IGFBP3, GH1, SHBG, LEPQTL1, ANXA6
43prednisolone43 28 1210.0LEPQTL1, TF, IGFBP3, GH1, ALB, SHBG
44thyroxine43 249.0ALB, GH1, IGFBP3, TF, SHBG, LEPQTL1
45lactate438.0ALB, SHBG, LEPQTL1, GH1, TF, IGFBP3
46creatinine438.0SHBG, TF, GH1, ALB, LEPQTL1, IGFBP3
47aspartate438.0IGFBP3, TF, SHBG, GH1, ALB, LEPQTL1
48alanine438.0TF, LEPQTL1, SHBG, GH1, ALB, IGFBP3
49cholesterol43 28 24 1210.6LEPQTL1, SHBG, TF, ALB, IGFBP3, ANXA6
50lipid437.5ALB, GH1, ANXA6, SHBG, LEPQTL1

GO Terms for genes affiliated with Marasmus

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Cellular components related to Marasmus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.7ALB, GH1, IGFBP3, TF
2extracellular regionGO:00055767.8ALB, GH1, SHBG, IGFBP3, TF

Biological processes related to Marasmus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:00435689.6GH1, IGFBP3
2platelet degranulationGO:00025769.5ALB, TF
3retina homeostasisGO:00018959.2ALB, TF

Products for genes affiliated with Marasmus

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Sources for Marasmus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet