MCID: MRS001
MIFTS: 39

Marasmus malady

Metabolic category

Summaries for Marasmus

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64Wikipedia, 33MalaCards
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Wikipedia:64 Marasmus is a form of severe malnutrition characterized by energy deficiency. A child with marasmus... more...

MalaCards: Marasmus, also known as nutritional marasmus, is related to anorexia nervosa and kwashiorkor. An important gene associated with Marasmus is GH1 (growth hormone 1), and among its related pathways is Selected targets of C/EBPalpha. The compounds estradiol and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex.

Aliases & Classifications for Marasmus

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Metabolic


Aliases & Descriptions:

marasmus 8 45 61
nutritional marasmus 8
nutritional atrophy 8


External Ids:

Disease Ontology8 DOID:12328
ICD9CM27 261
MeSH35 D011502
ICD1025 E41

Related Diseases for Marasmus

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Marasmus:



Diseases related to marasmus

Clinical Features for Marasmus

Drugs & Therapeutics for Marasmus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Marasmus

Drug clinical trials:

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Search NIH Clinical Center for Marasmus

Search CenterWatch for Marasmus

Genetic Tests for Marasmus

Anatomical Context for Marasmus

Sources:
33MalaCards
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MalaCards organs/tissues related to Marasmus:

33
Whole blood, Brain, Cortex, Small intestine, Liver, Pancreas, Breast, Adrenal cortex

Animal Models for Marasmus or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Marasmus

Sources:
51PubMed
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Articles related to Marasmus:

(show top 50)    (show all 196)
idTitleAuthorsYear
1
Prenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model. (22558267)
2012
2
The quality of the diet in Malawian children with kwashiorkor and marasmus. (16881921)
2006
3
Plasma fatty acids in children with grade III protein-energy malnutrition in its different clinical forms: marasmus, marasmic kwashiorkor, and kwashiorkor. (10341499)
1999
4
Red blood cell antioxidant enzyme concentrations in kwashiorkor and marasmus. (7681643)
1993
5
Risk factors for clinical marasmus: a case-control study of Bangladeshi children. (8505185)
1993
6
The exocrine pancreas in kwashiorkor and marasmus. Light and electron microscopy. (1523833)
1992
7
Long-term effects of early kwashiorkor compared with marasmus. I. Physical growth and sexual maturation. (3119811)
1987
8
Screening for marasmus: a discriminant analysis as a guide to choose the anthropometric variables. (3101482)
1987
9
Long-term effects of early kwashiorkor compared with marasmus. III. Fine motor skills. (3119813)
1987
10
Biochemical aspects of malabsorption in marasmus: effect of dietary rehabilitation. (3939688)
1985
11
Marasmus in a 17-month-old Laotian: impact of folk beliefs on health. (6420766)
1984
12
Calcium metabolism in marasmus. (6442922)
1984
13
Urinary catecholamine in kwashiorkor and marasmus. (6819336)
1982
14
Beetle marasmus. (6794839)
1981
15
The biochemistry and physiology of kwashiorkor and marasmus. (6789923)
1981
16
Blood plasma levels of cortisol, insulin, growth hormone and somatomedin in children with marasmus, kwashiorkor, and intermediate forms of protein-energy malnutrition. (6792631)
1981
17
Acult marasmus and cellular immunity. (416404)
1978
18
Study of digestion and absorption in marasmus. (417997)
1977
19
Decreased interferon production by leukocytes in marasmus. (180790)
1976
20
Adrenal function in normal infants and in marasmus and kwashiorkor. Cortisol secretion, diurnal variation of plasma cortisol, and urinary excretion of 17-hydroxycorticoids, free corticoids, and cortisol. (803388)
1975
21
Factors leading to severe malnutrition. A relationship of maternal nutrition and marasmus in the infants. (808477)
1975
22
Letter: Evolution of kwashiorkor and marasmus. (4136898)
1974
23
Hair tissue in the diagnosis of marasmus and kwashiorkor. (4354201)
1973
24
Plasma nonessential to essential amino acid ratio in marasmus. (4633701)
1973
25
The liver in pre-kwashiorkor and kwashiorkor-marasmus syndromes. (4625994)
1972
26
Galen on marasmus. (4946290)
1971
27
Comparison of half-cream powdered milk and full-cream acidified powdered milk as a diet for marasmus. (5468187)
1970
28
Hair-root adaptation to marasmus in Andean Indian children. (4188279)
1969
29
Serum proteins in kwashiorkor and marasmus: 3. Non-diarrhoeic and diarrhoeic cases. (5731043)
1968
30
Treatment of severe kwashiorkor and marasmus in hospital. (5681577)
1968
31
Electrocardiographic changes in kwashiorkor and marasmus. (5683136)
1968
32
Serum proteins in kwashiorkor and marasmus: 1. Unselected series before treatment. (5713699)
1968
33
Serum proteins in kwashiorkor and marasmus. 2. Non-tuberculous cases and tuberculous cases. (5305683)
1968
34
Defining marasmus and kwashiorkor. (5666198)
1968
35
Effect of human growth hormone in kwashiorkor and marasmus. (6019465)
1967
36
Nutritional marasmus in Bantu infants in the Pretoria area. 3. The effect of caloric intake on nitrogen and fat balance, certain serum constituents and the rate of recovery. (5952174)
1966
37
Nutritional marasmus in Bantu infants in the Pretoria area. II. Clinical and pathological aspects. (5829053)
1965
38
CHOLESTEROL REGENERATION DURING RECOVERY FROM KWASHIORKOR AND MARASMUS. (14281060)
1965
39
KERATOMALACIA IN KWASHIORKOR AND MARASMUS. (14281021)
1964
40
INTRAVENOUS GLUCOSE TOLERANCE IN KWASHIORKOR AND MARASMUS. (14145116)
1964
41
Kwashiorkor and marasmus: a note on fatal cases. (13968004)
1963
42
Liver compositionin kwashiorkor and marasmus. (14472561)
1962
43
Adrenal function in kwashiorkor and marasmus. (14467480)
1962
44
Marasmus: treatment with whole milk as compared to skimed milk. (14020395)
1962
45
Fat in faecal smears in kwashiorkor and marasmus: preliminary report. (14020397)
1962
46
The haematological picture in kwashiorkor and marasmus. (14419343)
1960
47
Treatment in pediatric practice; management of marasmus. (13620322)
1958
48
Anaemia and marasmus in Indian troops on active service. (18878517)
1948
49
On the Atrophic Marasmus of Nurslings (So-Called Hospitalism or Athrepsy of Parrot). (20758462)
1899
50
Report on the Pathology of Infantile Marasmus. (20756465)
1896

Genetic Variations for Marasmus

Expression for genes affiliated with Marasmus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Marasmus

Search GEO for disease gene expression data for Marasmus.

Pathways for genes affiliated with Marasmus

Sources:
12EMD Millipore
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Pathways related to Marasmus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ALB, TF

Compounds for genes affiliated with Marasmus

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
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Compounds related to Marasmus according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1estradiol45 11 2412.2SHBG
2tamoxifen45 50 29 1113.1LSL
3kp-1019459.8ALB, TF
4Bismuth Subsalicylate119.8ALB, TF
5raloxifene45 29 50 1112.7LSL, GH1
6bismuth45 2410.5ALB, TF
7rosiglitazone45 50 29 11 2413.5LSL, SHBG
8oxandrolone45 1110.4SHBG, GH1, IGFBP3
9anastrozole45 1110.4GH1, IGFBP3, SHBG
10oxcarbazepine45 1110.4SHBG, ALB
11clomiphene citrate459.4SHBG, IGFBP3, GH1
12diazoxide45 60 29 1112.4GH1, IGFBP3, SHBG
13glucose459.3LSL, IGFBP3
14bromocriptine29 45 1111.3SHBG, GH1, IGFBP3
15progestins459.3SHBG, GH1, IGFBP3
16Norethindrone119.2SHBG, ALB
17estrone sulfate45 2410.2IGFBP3, SHBG, ALB
18acth459.2IGFBP3, GH1, LSL
1925-hydroxyvitamin d459.2IGFBP3, SHBG, ALB
20Methyltestosterone119.0SHBG, ALB
21octreotide45 60 29 1112.0GH1, IGFBP3, LSL
22vitamin b12458.9ALB, IGFBP3, SHBG, TF
23calcitriol45 60 11 2411.8ALB, IGFBP3, SHBG, GH1
24metformin45 50 1110.8SHBG, GH1, LSL
25carbamazepine45 50 1110.8SHBG, LSL, IGFBP3
26vitamin d458.7ALB, SHBG, GH1, IGFBP3
27ascorbic acid45 249.7SHBG, TF, IGFBP3, ALB
28valproic acid45 50 11 2411.7ALB, IGFBP3, LSL
29deoxypyridinoline458.6IGFBP3, GH1, LSL, SHBG
30dehydroepiandrosterone sulfate458.6IGFBP3, SHBG, LSL, GH1
31hydrocortisone45 2 60 1111.6LSL, TF, GH1, SHBG
32c-peptide458.6SHBG, GH1, LSL, IGFBP3
33dhea458.6IGFBP3, GH1, LSL, SHBG
34triiodothyronine458.6SHBG, IGFBP3, LSL, GH1
35androstenedione45 249.6LSL, SHBG, IGFBP3, GH1
36glycerol45 11 2410.6IGFBP3, SHBG, GH1, LSL
37carbohydrates458.5IGFBP3, SHBG, TF, LSL
38gnrh458.5IGFBP3, SHBG, GH1, LSL
39methotrexate45 50 1110.3ALB, IGFBP3, GH1, TF, LSL
40epinephrine45 11 2410.2IGFBP3, SHBG, TF, LSL, GH1
41estrone45 29 11 2411.1SHBG, ALB, IGFBP3, GH1, LSL
42alanine458.1ALB, SHBG, LSL, TF, GH1
43progesterone45 60 29 11 2412.0LSL, GH1, SHBG, ANXA6, IGFBP3
44testosterone45 60 11 2411.0LSL, IGFBP3, SHBG, GH1, ALB
45prednisolone45 29 119.7ALB, IGFBP3, LSL, TF, GH1, SHBG
46thyroxine45 248.7IGFBP3, ALB, TF, LSL, SHBG, GH1
47lactate457.7GH1, TF, LSL, IGFBP3, ALB, SHBG
48creatinine457.7GH1, IGFBP3, TF, SHBG, ALB, LSL
49aspartate457.7SHBG, GH1, IGFBP3, LSL, ALB, TF
50cholesterol45 29 11 2410.5LSL, ALB, TF, ANXA6, SHBG, IGFBP3

GO Terms for genes affiliated with Marasmus

Sources:
16Gene Ontology
See all sources

Cellular components related to Marasmus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1ALB, IGFBP3, SHBG, GH1, TF

Biological processes related to Marasmus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.6IGFBP3, GH1

Products for genes affiliated with Marasmus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Marasmus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet