MCID: MRS001
MIFTS: 44

Marasmus malady

Summaries for Marasmus

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66Wikipedia, 34MalaCards
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Wikipedia:66 Marasmus is a form of severe malnutrition characterized by energy deficiency. A child with marasmus... more...

MalaCards: Marasmus, also known as nutritional marasmus, is related to protein-energy malnutrition and hepatitis. An important gene associated with Marasmus is GH1 (growth hormone 1), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Selected targets of C EBPalpha. The compounds kp-1019 and oxandrolone have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and bone.

Aliases & Classifications for Marasmus

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9Disease Ontology, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Classifications:



Aliases & Descriptions:

marasmus 9 46 63
nutritional marasmus 9
nutritional atrophy 9


External Ids:

Disease Ontology9 DOID:12328
MeSH36 D011502
ICD9CM28 261
ICD1026 E41

Related Diseases for Marasmus

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18GeneCards, 19GeneDecks
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Diseases related to Marasmus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1protein-energy malnutrition30.4ALB, LEPQTL1, TF
2hepatitis30.2ALB, TF
3proteinuria30.0ALB, LEPQTL1, TF
4anorexia nervosa29.9GH1, SHBG, LEPQTL1, IGFBP3
5kwashiorkor11.0
6riboflavin deficiency10.2
7keratomalacia10.1
8hypoadrenalism10.1GH1
9rabson-mendenhall syndrome10.1IGFBP3
10turner syndrome10.1IGFBP3
11siderosis10.1TF
12laron syndrome10.1GH1, IGFBP3
13acromegaly10.1IGFBP3, GH1
14insulin-like growth factor 1 resistance to10.1IGFBP3, GH1
15idiopathic juvenile osteoporosis10.1GH1, IGFBP3
16growth retardation-mild developmental delay-chronic hepatitis syndrome10.1GH1, IGFBP3
17dwarfism10.1IGFBP3, GH1
18short bowel syndrome10.1GH1, ALB
19mastitis10.1ALB, GH1
20protein-losing enteropathy10.0TF, ALB
21lipoid nephrosis10.0ALB, TF
22prader-willi syndrome10.0LEPQTL1, GH1
23cushing's syndrome10.0GH1, LEPQTL1
24cork-handlers' disease10.0ALB, TF
25primary hyperoxaluria10.0ALB, TF
26growth hormone deficiency10.0IGFBP3, LEPQTL1, GH1
27anovulation10.0IGFBP3, SHBG
28hyperprolactinemia10.0GH1, SHBG
29premature ovarian failure10.0SHBG, IGFBP3
30hypoglycemia10.0IGFBP3, LEPQTL1, GH1
31nutritional deficiency disease10.0TF, IGFBP3, ALB
32nephrotic syndrome10.0ALB, TF
33hepatitis c10.0LEPQTL1, TF
34bronchitis10.0TF, SHBG
35gestational diabetes10.0SHBG, LEPQTL1
36alcoholic liver cirrhosis10.0TF, LEPQTL1, ALB
37uterine fibroid10.0SHBG, LEPQTL1
38fatty liver disease10.0LEPQTL1, TF
39deficiency anemia10.0ALB, LEPQTL1, TF
40hypopituitarism10.0GH1, SHBG, IGFBP3
41polycystic ovary syndrome10.0IGFBP3, SHBG, GH1
42short stature10.0GH1, SHBG, IGFBP3
43hypertriglyceridemia10.0SHBG, LEPQTL1
44metabolic syndrome x10.0GH1, SHBG, TF
45pure red-cell aplasia10.0
46peliosis hepatis10.0
47rickets10.0
48cerebritis10.0
49shigellosis10.0
50megaloblastic anemia10.0

Graphical network of the top 20 diseases related to Marasmus:



Diseases related to marasmus

Symptoms for Marasmus

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Drugs & Therapeutics for Marasmus

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Marasmus

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Anatomical Context for Marasmus

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34MalaCards
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MalaCards organs/tissues related to Marasmus:

34
Liver, Testes, Bone, Brain, Cortex, Small intestine, Pancreas, Breast, Adrenal cortex

Animal Models for Marasmus or affiliated genes

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Publications for Marasmus

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53PubMed
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Articles related to Marasmus:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test. (24114907)
2013
2
Prenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model. (22558267)
2012
3
Using of WHO guidelines for the management of severe malnutrition to cases of marasmus and kwashiorkor in a Colombia children's hospital. (22072341)
2011
4
Lipid kinetic differences between children with kwashiorkor and those with marasmus. (16762938)
2006
5
Plasma fatty acids in children with grade III protein-energy malnutrition in its different clinical forms: marasmus, marasmic kwashiorkor, and kwashiorkor. (10341499)
1999
6
Whole-body protein kinetics in marasmus and kwashiorkor during acute infection. (9625094)
1998
7
Fatty acid composition of erythrocyte membrane lipid obtained from children suffering from kwashiorkor and marasmus. (2115964)
1990
8
Long-term effects of early kwashiorkor compared with marasmus. I. Physical growth and sexual maturation. (3119811)
1987
9
Screening for marasmus: a discriminant analysis as a guide to choose the anthropometric variables. (3101482)
1987
10
Biochemical aspects of malabsorption in marasmus: effect of dietary rehabilitation. (3939688)
1985
11
Marasmus. (3939295)
1985
12
Marasmus--1985. (3932990)
1985
13
Marasmus in a 17-month-old Laotian: impact of folk beliefs on health. (6420766)
1984
14
Urinary catecholamine in kwashiorkor and marasmus. (6819336)
1982
15
Infection and the development of kwashiorkor and marasmus in Africa. (407786)
1977
16
The role of the adrenal cortex in the development of marasmus. (408764)
1977
17
Adrenal cortical function in marasmus. (417998)
1977
18
Metabolic and hormonal responses to a protein-glucose meal in normal infants and in marasmus and marasmic kwashiorkor. (823521)
1976
19
Conduction velocity of motor nerves in children suffering from protein-calorie malnutrition and marasmus. (826388)
1976
20
Decreased interferon production by leukocytes in marasmus. (180790)
1976
21
Studies on kwashiorkor and marasmus in Calcutta (1957-74): III. Therapeutic and follow-up studies. (819366)
1975
22
Cortisol and growth hormone in kwashiorkor and marasmus. (809848)
1975
23
Marasmus and Pneumocystis carinii pneumonia in institutionalised infants. Observations during an endemic. (4213237)
1974
24
Studies on the anaemia of kwashiorkor and marasmus in the Sudan. (4492791)
1973
25
Jejunal disaccharidase activities in children with marasmus and with kwashiorkor. Response to treatment. (5576036)
1971
26
Immunoglobulins in marasmus. (4099453)
1970
27
Serm proteins in kwashiorkor and marasmus. 5. Correlations between hypoproteinaemia and anaemia, oedema and mortality. (5401894)
1969
28
Serum proteins in kwashiorkor and marasmus. 4. Cases with or without keratomalacia. (5401879)
1969
29
The concentration of copper, zinc and manganese in the liver of African children with marasmus and kwashiorkor. (5786622)
1969
30
Fat balance studies in marasmus. (5374759)
1969
31
Serum proteins in kwashiorkor and marasmus: 3. Non-diarrhoeic and diarrhoeic cases. (5731043)
1968
32
Treatment of severe kwashiorkor and marasmus in hospital. (5681577)
1968
33
Haemorrhagic manifestations in kwashiorkor and marasmus. (5306031)
1967
34
Kwashiorkor and marasmus. Blood sugar levels and response to epinephrine. (5846687)
1965
35
TOTAL BODY-POTASSIUM IN KWASHIORKOR AND MARASMUS. (14337823)
1965
36
STUDIES ON CREATININE METABOLISM IN KWASHIORKOR AND MARASMUS. (14286801)
1965
37
VACUOLISATION OF EARLY ERYTHROBLASTS IN RIBOFLAVINE-DEFICIENT BABOONS AND IN MARASMUS AND KWASHIORKOR. (14213578)
1964
38
KERATOMALACIA IN KWASHIORKOR AND MARASMUS. (14281021)
1964
39
MARASMUS IN SOUTH AFRICAN BANTU CHILDREN. (14045805)
1963
40
Cali-Harvard nutrition project. II. The erythroid atrophy of kwashiorkor and marasmus. (13947506)
1963
41
Red-cell aplasia in marasmus and kwashiorkor. (14458154)
1962
42
Aetiological investigations in kwashiorkor and marasmus. II. Study of socio-economic aspects. (13968005)
1962
43
Pure red-cell aplasia in marasmus and kwashiorkor treated with riboflavine. (13701132)
1961
44
Electrophoretic pattern of plasma proteins in clinically diagnosed cases of kwashiorkor (protein malnutrition) and undernutrition (marasmus) among Ceylonese children. (13796495)
1959
45
Treatment in pediatric practice; management of marasmus. (13620322)
1958
46
Protein requirements of infants; marasmus. (15409286)
1949
47
A case of infantile wasting (marasmus). (18921037)
1947
48
Marasmus. (21312453)
1926
49
The Etiology of some Forms of Marasmus in Infancy, its Treatment by Lactic Acid Whole Milk. (20314244)
1922
50
On the Atrophic Marasmus of Nurslings (So-Called Hospitalism or Athrepsy of Parrot). (20758462)
1899

Variations for Marasmus

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Expression for genes affiliated with Marasmus

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Marasmus

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Pathways for genes affiliated with Marasmus

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51PathCards, 56Reactome, 13EMD Millipore
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Pathways related to Marasmus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5ALB, TF
29.5ALB, TF

Compounds for genes affiliated with Marasmus

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Marasmus according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1kp-1019469.8ALB, TF
2oxandrolone46 1210.5GH1, IGFBP3, SHBG
3anastrozole46 52 1211.4IGFBP3, SHBG, GH1
4clomiphene citrate469.4IGFBP3, GH1, SHBG
5diazoxide46 62 30 1212.4IGFBP3, SHBG, GH1
6bromocriptine46 30 1211.3SHBG, GH1, IGFBP3
7octreotide46 62 30 1212.3LEPQTL1, GH1, IGFBP3
8progestins469.3SHBG, GH1, IGFBP3
9estrone sulfate46 2510.2IGFBP3, ALB, SHBG
1025-hydroxyvitamin d469.2ALB, IGFBP3, SHBG
11procollagen469.2GH1, LEPQTL1, IGFBP3
12carbamazepine46 52 1211.1SHBG, LEPQTL1, IGFBP3
13alpha tocopherol469.1TF, IGFBP3, ALB
14metformin46 52 1211.0SHBG, GH1, LEPQTL1
15deoxypyridinoline469.0GH1, SHBG, LEPQTL1, IGFBP3
16dehydroepiandrosterone sulfate469.0GH1, SHBG, LEPQTL1, IGFBP3
17raloxifene46 52 30 1212.0LEPQTL1, GH1, SHBG, IGFBP3
18c-peptide469.0LEPQTL1, SHBG, GH1, IGFBP3
19dhea469.0SHBG, LEPQTL1, IGFBP3, GH1
20triiodothyronine468.9LEPQTL1, GH1, IGFBP3, SHBG
21androstenedione46 259.9LEPQTL1, IGFBP3, SHBG, GH1
22glycerol46 25 1210.9IGFBP3, SHBG, LEPQTL1, GH1
23acth468.9SHBG, LEPQTL1, GH1, IGFBP3
24hydrocortisone46 3 62 1211.9TF, LEPQTL1, SHBG, GH1
25calcitriol46 62 25 1211.9SHBG, IGFBP3, GH1, ALB
26vitamin b12468.9TF, IGFBP3, SHBG, ALB
27gnrh468.9IGFBP3, LEPQTL1, SHBG, GH1
28carbohydrates468.8SHBG, IGFBP3, TF, LEPQTL1
29vitamin d468.8ALB, GH1, IGFBP3, SHBG
30ascorbic acid46 259.7SHBG, IGFBP3, TF, ALB
31valproic acid46 52 25 1211.7LEPQTL1, IGFBP3, ALB
32methotrexate52 46 1210.6LEPQTL1, ALB, TF, GH1, IGFBP3
33epinephrine46 25 1210.5GH1, LEPQTL1, IGFBP3, TF, SHBG
34tamoxifen46 52 30 1211.5SHBG, LEPQTL1, TF, IGFBP3, GH1
35norepinephrine46 25 1210.5SHBG, GH1, LEPQTL1, IGFBP3, TF
36estrone46 30 25 1211.5LEPQTL1, GH1, IGFBP3, ALB, SHBG
37rosiglitazone30 46 52 25 1212.5IGFBP3, LEPQTL1, SHBG, GH1, ALB
38estradiol46 25 1210.4GH1, IGFBP3, LEPQTL1, SHBG, ALB
39testosterone46 62 25 1211.4LEPQTL1, GH1, IGFBP3, ALB, SHBG
40estrogen468.3GH1, SHBG, LEPQTL1, IGFBP3, TF
41glucose468.1ALB, GH1, SHBG, LEPQTL1, IGFBP3
42progesterone46 30 62 25 1212.1IGFBP3, GH1, SHBG, LEPQTL1, ANXA6
43prednisolone46 30 1210.0LEPQTL1, TF, IGFBP3, GH1, ALB, SHBG
44thyroxine46 259.0ALB, GH1, IGFBP3, TF, SHBG, LEPQTL1
45lactate468.0ALB, SHBG, LEPQTL1, GH1, TF, IGFBP3
46creatinine468.0SHBG, TF, GH1, ALB, LEPQTL1, IGFBP3
47aspartate468.0IGFBP3, TF, SHBG, GH1, ALB, LEPQTL1
48alanine468.0TF, LEPQTL1, SHBG, GH1, ALB, IGFBP3
49cholesterol46 30 25 1210.6LEPQTL1, SHBG, TF, ALB, IGFBP3, ANXA6
50lipid467.5ALB, GH1, ANXA6, SHBG, LEPQTL1

GO Terms for genes affiliated with Marasmus

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17Gene Ontology
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Cellular components related to Marasmus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7ALB, GH1, IGFBP3, TF
2extracellular regionGO:0055767.8ALB, GH1, SHBG, IGFBP3, TF

Biological processes related to Marasmus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.6GH1, IGFBP3
2platelet degranulationGO:0025769.5ALB, TF
3retina homeostasisGO:0018959.2ALB, TF

Products for genes affiliated with Marasmus

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  • Antibodies
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Sources for Marasmus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet