MCID: MRS001
MIFTS: 44

Marasmus malady

Metabolic diseases category

Summaries for Marasmus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Marasmus is a form of severe malnutrition characterized by energy deficiency. A child with marasmus... more...

MalaCards: Marasmus, also known as nutritional marasmus, is related to protein-energy malnutrition and hepatitis. An important gene associated with Marasmus is GH1 (growth hormone 1), and among its related pathways is Selected targets of C/EBPalpha. The compounds estradiol and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and bone.

Aliases & Classifications for Marasmus

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

marasmus 8 44 60
nutritional marasmus 8
nutritional atrophy 8


External Ids:

Disease Ontology8 DOID:12328
ICD9CM27 261
MeSH34 D011502
ICD1025 E41

Related Diseases for Marasmus

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Marasmus:



Diseases related to marasmus

Clinical Features for Marasmus

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Drugs & Therapeutics for Marasmus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Marasmus

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Anatomical Context for Marasmus

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32MalaCards
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MalaCards organs/tissues related to Marasmus:

32
Liver, Testes, Bone, Brain, Breast, Small intestine, Pancreas, Cortex, Adrenal cortex

Animal Models for Marasmus or affiliated genes

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Publications for Marasmus

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50PubMed
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Articles related to Marasmus:

(show top 50)    (show all 196)
idTitleAuthorsYear
1
Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic I^-cell dysfunction. (22386944)
2012
2
Reduced production of sulfated glycosaminoglycans occurs in Zambian children with kwashiorkor but not marasmus. (19116330)
2009
3
Serum concentrations of sex hormone binding globulin are elevated in kwashiorkor and anorexia nervosa but not in marasmus. (12081841)
2002
4
Plasma concentration of taurine is higher in malnourished than control children: differences between kwashiorkor and marasmus. (9635065)
1998
5
Red blood cell antioxidant enzyme concentrations in kwashiorkor and marasmus. (7681643)
1993
6
Mild-moderate Kwashiorkor-Marasmus syndrome: anthropometric and biochemical observations. (2518626)
1989
7
Long-term effects of early kwashiorkor compared with marasmus. I. Physical growth and sexual maturation. (3119811)
1987
8
Screening for marasmus: a discriminant analysis as a guide to choose the anthropometric variables. (3101482)
1987
9
Long-term effects of early kwashiorkor compared with marasmus. III. Fine motor skills. (3119813)
1987
10
Marasmus. (3939295)
1985
11
Biochemical aspects of malabsorption in marasmus. (6418198)
1984
12
Controlled trial of copper supplementation during the recovery from marasmus. (6405607)
1983
13
Gastric mucosal functions and histology in marasmus. (6819226)
1982
14
Observations on thrombolastographic patterns and coagulation changes in malnutrition (Marasmus and Kwashiorkor). (120322)
1979
15
Daily urinary catecholamine profile in marasmus and kwashiorkor. (413428)
1978
16
The role of the adrenal cortex in the development of marasmus. (408764)
1977
17
Cellular immunity in adult marasmus. (411436)
1977
18
Study of digestion and absorption in marasmus. (417997)
1977
19
Metabolic and hormonal responses to a protein-glucose meal in normal infants and in marasmus and marasmic kwashiorkor. (823521)
1976
20
Studies on kwashiorkor and marasmus in Calcutta (1957-74): II. Pathological, biochemical and metabolic studies. (819365)
1975
21
Motor nerve conduction velocity in marasmus and in kwashiorkor. (4406228)
1974
22
Letter: Evolution of kwashiorkor and marasmus. (4136898)
1974
23
Marasmus and shigellosis in two infant gorillas. (4449117)
1974
24
Adrenal function in normal infants and in marasmus and kwashiorkor: plasma aldosterone concentration and aldosterone secretion rate. (4204569)
1974
25
Evolution of kwashiorkor and marasmus. (4132426)
1974
26
Studies on the anaemia of kwashiorkor and marasmus in the Sudan. (4492791)
1973
27
Behavior of infant in causation of nutritional marasmus. (4632066)
1973
28
Plasma nonessential to essential amino acid ratio in marasmus. (4633701)
1973
29
Growth hormone in marasmus die to cerebral disease. (4746543)
1973
30
Comparative trial of Liv 52 and Orabolin in marasmus. (4644287)
1972
31
Immunoglobulins in marasmus. (4099453)
1970
32
Serum proteins in kwashiorkor and marasmus. 4. Cases with or without keratomalacia. (5401879)
1969
33
Fat balance studies in marasmus. (5374759)
1969
34
Treatment of severe kwashiorkor and marasmus in hospital. (5681577)
1968
35
Comparison between erythroid aplasia in marasmus and kwashiorkor and the experimentally induced erythroid aplasia in baboons by riboflavin deficiency. (4975852)
1968
36
Erythroid aplasia in riboflavin-deficient baboons and its relation to marasmus and kwashiorkor. (4965450)
1967
37
The concentration of copper in the liver of African children with marasmus. (5006473)
1967
38
CHOLESTEROL REGENERATION DURING RECOVERY FROM KWASHIORKOR AND MARASMUS. (14281060)
1965
39
Anabolic steroids in nutritional marasmus. (5827192)
1965
40
SERUM ENZYME LEVELS IN PROTEIN-CALORIE MALNUTRITION. STUDIES IN CHILDREN WITH KWASHIORKOR AND MARASMUS. (14095111)
1964
41
MARASMUS IN SOUTH AFRICAN BANTU CHILDREN. (14045805)
1963
42
Cali-Harvard nutrition project. II. The erythroid atrophy of kwashiorkor and marasmus. (13947506)
1963
43
Kwashiorkor and marasmus: a note on fatal cases. (13968004)
1963
44
Kwashiorkor and marasmus: follow-up study. (13968007)
1962
45
Fat in faecal smears in kwashiorkor and marasmus: preliminary report. (14020397)
1962
46
MARASMUS today. (13011955)
1953
47
Protein requirements of infants; marasmus. (15409286)
1949
48
Marasmus treated by Breast-Milk. (19992218)
1940
49
Report on the Pathology of Infantile Marasmus. (20756465)
1896
50
On Marasmus as an Occasional Consequence of Enteric Fever. (20746413)
1871

Genetic Variations for Marasmus

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Expression for genes affiliated with Marasmus

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Marasmus

Search GEO for disease gene expression data for Marasmus.

Pathways for genes affiliated with Marasmus

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12EMD Millipore
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Pathways related to Marasmus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ALB, TF

Compounds for genes affiliated with Marasmus

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Marasmus according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2412.2SHBG
2tamoxifen44 49 28 1113.1LSL
3kp-1019449.8ALB, TF
4Bismuth Subsalicylate119.8ALB, TF
5raloxifene44 28 49 1112.7LSL, GH1
6bismuth44 2410.5ALB, TF
7rosiglitazone44 49 28 11 2413.5LSL, SHBG
8oxandrolone44 1110.4SHBG, GH1, IGFBP3
9anastrozole44 1110.4GH1, IGFBP3, SHBG
10oxcarbazepine44 1110.4SHBG, ALB
11clomiphene citrate449.4SHBG, IGFBP3, GH1
12diazoxide44 59 28 1112.4GH1, IGFBP3, SHBG
13glucose449.3LSL, IGFBP3
14bromocriptine28 44 1111.3SHBG, GH1, IGFBP3
15progestins449.3SHBG, GH1, IGFBP3
16Norethindrone119.2SHBG, ALB
17estrone sulfate44 2410.2IGFBP3, SHBG, ALB
18acth449.2IGFBP3, GH1, LSL
1925-hydroxyvitamin d449.2IGFBP3, SHBG, ALB
20Methyltestosterone119.0SHBG, ALB
21octreotide44 59 28 1112.0GH1, IGFBP3, LSL
22vitamin b12448.9ALB, IGFBP3, SHBG, TF
23calcitriol44 59 11 2411.8ALB, IGFBP3, SHBG, GH1
24metformin44 49 1110.8SHBG, GH1, LSL
25carbamazepine44 49 1110.8SHBG, LSL, IGFBP3
26vitamin d448.7ALB, SHBG, GH1, IGFBP3
27ascorbic acid44 249.7SHBG, TF, IGFBP3, ALB
28valproic acid44 49 11 2411.7ALB, IGFBP3, LSL
29deoxypyridinoline448.6IGFBP3, GH1, LSL, SHBG
30dehydroepiandrosterone sulfate448.6IGFBP3, SHBG, LSL, GH1
31hydrocortisone44 2 59 1111.6LSL, TF, GH1, SHBG
32c-peptide448.6SHBG, GH1, LSL, IGFBP3
33dhea448.6IGFBP3, GH1, LSL, SHBG
34triiodothyronine448.6SHBG, IGFBP3, LSL, GH1
35androstenedione44 249.6LSL, SHBG, IGFBP3, GH1
36glycerol44 11 2410.6IGFBP3, SHBG, GH1, LSL
37carbohydrates448.5IGFBP3, SHBG, TF, LSL
38gnrh448.5IGFBP3, SHBG, GH1, LSL
39methotrexate44 49 1110.3ALB, IGFBP3, GH1, TF, LSL
40epinephrine44 11 2410.2IGFBP3, SHBG, TF, LSL, GH1
41estrone44 28 11 2411.1SHBG, ALB, IGFBP3, GH1, LSL
42alanine448.1ALB, SHBG, LSL, TF, GH1
43progesterone44 59 28 11 2412.0LSL, GH1, SHBG, ANXA6, IGFBP3
44testosterone44 59 11 2411.0LSL, IGFBP3, SHBG, GH1, ALB
45prednisolone44 28 119.7ALB, IGFBP3, LSL, TF, GH1, SHBG
46thyroxine44 248.7IGFBP3, ALB, TF, LSL, SHBG, GH1
47lactate447.7GH1, TF, LSL, IGFBP3, ALB, SHBG
48creatinine447.7GH1, IGFBP3, TF, SHBG, ALB, LSL
49aspartate447.7SHBG, GH1, IGFBP3, LSL, ALB, TF
50cholesterol44 28 11 2410.5LSL, ALB, TF, ANXA6, SHBG, IGFBP3

GO Terms for genes affiliated with Marasmus

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16Gene Ontology
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Cellular components related to Marasmus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1ALB, IGFBP3, SHBG, GH1, TF

Biological processes related to Marasmus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.6IGFBP3, GH1

Products for genes affiliated with Marasmus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Marasmus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet