MCID: MRK002
MIFTS: 31

Marek Disease malady

Neuronal diseases category

Summaries for Marek Disease

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Sources:
63Wikipedia, 32MalaCards
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Wikipedia:63 Marek\'s disease is a highly contagious viral neoplastic disease in chickens. It is named after József... more...

MalaCards: Marek Disease, also known as neurolymphomatosis, is related to mycosis fungoides and hodgkin's lymphoma. An important gene associated with Marek Disease is KRT75 (keratin 75), and among its related pathways are Signaling mediated by p38-alpha and p38-beta and DNA damage Role of SUMO in p53 regulation. The compounds pdtc and perillyl alcohol have been mentioned in the context of this disorder. Affiliated tissues include t cells.

Aliases & Classifications for Marek Disease

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Sources:
42NIH Rare Diseases, 60UMLS, 48Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

marek disease 42 60
neurolymphomatosis 42 48
marek's disease 42
fowl paralyses 42
fowl paralysis 42


Related Diseases for Marek Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Marek Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1mycosis fungoides10.1
2hodgkin's lymphoma10.1
3acute monocytic leukemia10.0CRAT
4dermatitis10.0TNFRSF1B
5dementia10.0TNFRSF1B
6psoriasis10.0TNFRSF1B
7hepatitis c10.0HMGCR
8ischemia10.0HMGCR
9psoriatic arthritis10.0TNFRSF1B
10synovitis10.0TNFRSF1B
11obesity10.0TNFRSF1B
12multiple myeloma10.0TP53
13pheochromocytoma10.0JUN
14medulloblastoma10.0TP53
15dermatomyositis10.0HMGCR
16kidney cancer10.0TP53
17crohn's disease10.0TNFRSF1B
18schizophrenia10.0TNFRSF1B
19neuroblastoma10.0TP53
20hepatitis b10.0CRAT, TNFRSF8
21hypertension10.0ACE
22myeloma10.0TNFRSF1B, TNFRSF8
23prion disease10.0JUN
24retinitis10.0GYPC
25myeloid leukemia10.0CRAT, JUN
26malaria10.0GYPC
27diabetic retinopathy10.0ACE
28asthma10.0JUN, TNFRSF8
29monocytic leukemia10.0JUN, CRAT
30osteoarthritis10.0TNFRSF1B, JUN
31endometriosis10.0TNFRSF1B, HMGCR
32pneumonia10.0TNFRSF1B, JUN
33colorectal cancer10.0TNFRSF1B, TP53
34myositis10.0TNFRSF1B, HMGCR
35anaplastic large cell lymphoma10.0TNFRSF8, JUN
36adult-onset still's disease10.0TNFRSF1B
37sarcoma10.0TNFRSF1B, TP53
38essential hypertension10.0ACE, TNFRSF1B
39adenocarcinoma10.0TP53, HMGCR
40tuberculosis10.0TNFRSF8, CRAT, TNFRSF1B
41peripheral vascular disease10.0HMGCR, ACE
42allergic rhinitis10.0TNFRSF8
43sudden cardiac death multi-gene panels10.0HMGCR, ACE
44proteinuria10.0HMGCR, ACE
45embryonal cancer10.0CRAT, JUN, TNFRSF8
46fibrosarcoma10.0CRAT, TNFRSF1B, JUN
47hypercholesterolemia10.0HMGCR, ACE
48hepatoblastoma10.0CRAT, JUN, HMGCR
49t-cell leukemia10.0CRAT, JUN, TNFRSF8
50adrenocortical carcinoma10.0TP53, CRAT

Graphical network of the top 20 diseases related to Marek Disease:



Diseases related to marek disease

Clinical Features for Marek Disease

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Drugs & Therapeutics for Marek Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Marek Disease

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Anatomical Context for Marek Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Marek Disease:

32
T cells

Animal Models for Marek Disease or affiliated genes

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Publications for Marek Disease

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Genetic Variations for Marek Disease

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Expression for genes affiliated with Marek Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Marek Disease

Search GEO for disease gene expression data for Marek Disease.

Pathways for genes affiliated with Marek Disease

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 29KEGG, 55SinoBiological, 52R&D Systems
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Compounds for genes affiliated with Marek Disease

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Marek Disease according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1pdtc4410.5JUN
2perillyl alcohol44 2411.1JUN, HMGCR
3manidipine4410.1ACE, HMGCR
4ramipril44 1111.0ACE, HMGCR
5thiazide4410.0ACE, HMGCR
6diltiazem44 28 1112.0ACE, HMGCR
7irbesartan44 28 49 1113.0ACE, JUN
8amiodarone44 49 28 1113.0ACE, HMGCR
9amlodipine44 49 11 2412.9HMGCR, ACE
10dicoumarol449.8JUN, TP53
11sulindac sulfide449.8TP53, JUN
12serine449.8JUN, TNFRSF1B, HMGCR
13clopidogrel49 44 11 2412.8ACE, HMGCR
14cd 437449.7JUN, TP53
15butyrate449.7CRAT
16cerivastatin44 49 28 1112.7HMGCR, JUN
17radicicol44 59 1111.7JUN, TP53
18triptolide449.6JUN, TP53
19beta-naphthoflavone44 1110.6CRAT, JUN
20geldanamycin44 49 59 1112.5TP53, TNFRSF1B, JUN
21curcumin449.5TP53, TNFRSF1B, JUN
22lactacystin449.5TP53, HMGCR, JUN
23tamoxifen44 49 28 1112.3JUN, TNFRSF1B, CRAT
24aphidicolin449.3CRAT, TP53
25cyclosporin a44 28 5911.2JUN, TNFRSF8, TNFRSF1B, HMGCR
26sodium arsenite449.1TP53, JUN
2712-o-tetradecanoylphorbol 13-acetate449.1JUN, TNFRSF1B, CRAT
28vinblastine44 49 1111.0TP53, CRAT, JUN
29retinoid449.0JUN, CRAT, TP53
30etoposide44 49 59 1111.9TP53, CRAT, JUN
31threonine448.9GYPC, TNFRSF1B, TNFRSF8, JUN
32dexamethasone44 49 28 1111.9HMGCR, CRAT, TNFRSF1B, JUN
33vitamin d448.8JUN, TNFRSF1B, CRAT
34sodium44 249.7ACE, GYPC, CRAT, TNFRSF1B
35n acetylcysteine448.7JUN, CRAT, HMGCR, TP53
36paclitaxel44 49 1110.7TP53, HMGCR, CRAT
37oligonucleotide448.6JUN, TNFRSF1B, CRAT, TP53
38zinc44 249.6ACE, CRAT, TNFRSF1B, TNFRSF8
39arginine448.6TNFRSF1B, CRAT, HMGCR, TP53
40actinomycin d448.3TP53, HMGCR, CRAT, TNFRSF1B, JUN
41h2o2448.3JUN, TNFRSF1B, CRAT, HMGCR, TP53
42vegf448.3TP53, HMGCR, CRAT, TNFRSF1B, JUN
43thymidine44 249.0TP53, GYPC, CRAT, TNFRSF8, JUN
44lipid447.9TNFRSF8, TNFRSF1B, CRAT, GYPC, HMGCR, ACE

GO Terms for genes affiliated with Marek Disease

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Sources:
16Gene Ontology
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Biological processes related to Marek Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cardiac muscle cell apoptotic processGO:0106669.5TP53, HMGCR
2release of cytochrome c from mitochondriaGO:0018369.4TP53, JUN
3positive regulation of neuron apoptotic processGO:0435259.4TP53, JUN
4positive regulation of smooth muscle cell proliferationGO:0486619.4HMGCR, JUN
5protein tetramerizationGO:0512629.4HMGCR, TP53

Molecular functions related to Marek Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:0050319.6TNFRSF1B, TNFRSF8

Products for genes affiliated with Marek Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Marek Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet