MCID: MRK002
MIFTS: 31

Marek Disease malady

Neuronal category

Summaries for Marek Disease

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Marek\'s disease is a highly contagious viral neoplastic disease in chickens. It is named after József... more...

MalaCards: Marek Disease, also known as neurolymphomatosis, is related to mycosis fungoides and lymphoma, diffuse large cell. An important gene associated with Marek Disease is KRT75 (keratin 75), and among its related pathways are Signaling mediated by p38-alpha and p38-beta and DNA damage Role of SUMO in p53 regulation. The compounds pdtc and perillyl alcohol have been mentioned in the context of this disorder. Affiliated tissues include kidney and t cells.

Aliases & Classifications for Marek Disease

Sources:
43NIH Rare Diseases, 61UMLS, 49Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

marek disease 43 61
neurolymphomatosis 43 49
marek's disease 43
fowl paralyses 43
fowl paralysis 43


Related Diseases for Marek Disease

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Marek Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1mycosis fungoides10.1
2lymphoma, diffuse large cell10.1
3mononeuritis multiplex10.0
4testicular lymphoma10.0
5breast lymphoma10.0
6brachial plexus neuropathy10.0
7lymphoblastic lymphoma10.0
8neurosarcoidosis10.0
9lymphomatous meningitis10.0
10acute monocytic leukemia10.0CRAT
11dermatitis10.0TNFRSF1B
12dementia10.0TNFRSF1B
13psoriasis10.0TNFRSF1B
14hepatitis c10.0HMGCR
15ischemia10.0HMGCR
16psoriatic arthritis10.0TNFRSF1B
17synovitis10.0TNFRSF1B
18obesity10.0TNFRSF1B
19multiple myeloma10.0TP53
20pheochromocytoma10.0JUN
21medulloblastoma10.0TP53
22dermatomyositis10.0HMGCR
23kidney cancer10.0TP53
24crohn's disease10.0TNFRSF1B
25schizophrenia10.0TNFRSF1B
26neuroblastoma10.0TP53
27hepatitis b10.0CRAT, TNFRSF8
28hypertension10.0ACE
29myeloma10.0TNFRSF1B, TNFRSF8
30prion disease10.0JUN
31retinitis10.0GYPC
32myeloid leukemia10.0JUN, CRAT
33malaria10.0GYPC
34diabetic retinopathy10.0ACE
35asthma10.0JUN, TNFRSF8
36monocytic leukemia10.0JUN, CRAT
37osteoarthritis10.0JUN, TNFRSF1B
38endometriosis10.0HMGCR, TNFRSF1B
39pneumonia10.0JUN, TNFRSF1B
40colorectal cancer10.0TP53, TNFRSF1B
41myositis10.0HMGCR, TNFRSF1B
42anaplastic large cell lymphoma10.0TNFRSF8, JUN
43adult-onset still's disease10.0TNFRSF1B
44sarcoma10.0TP53, TNFRSF1B
45essential hypertension10.0ACE, TNFRSF1B
46adenocarcinoma10.0HMGCR, TP53
47tuberculosis10.0CRAT, TNFRSF1B, TNFRSF8
48peripheral vascular disease10.0ACE, HMGCR
49allergic rhinitis10.0TNFRSF8
50sudden cardiac death multi-gene panels10.0ACE, HMGCR

Graphical network of the top 20 diseases related to Marek Disease:



Diseases related to marek disease

Clinical Features for Marek Disease

Drugs & Therapeutics for Marek Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Marek Disease

Drug clinical trials:

Search ClinicalTrials for Marek Disease

Search NIH Clinical Center for Marek Disease

Search CenterWatch for Marek Disease

Genetic Tests for Marek Disease

Anatomical Context for Marek Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Marek Disease:

33
Kidney, T cells

Animal Models for Marek Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Marek Disease

Sources:
51PubMed
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Articles related to Marek Disease:

(show all 18)
idTitleAuthorsYear
1
In vitro and in vivo broad antiviral activity of peptides homologous to fusion glycoproteins of Newcastle disease virus and Marek's disease virus. (24412629)
2014
2
Avirulent Marek's disease virus type 1 strain 814 vectored vaccine expressing avian influenza (AI) virus H5 haemagglutinin induced better protection than turkey herpesvirus vectored AI vaccine. (23301062)
2013
3
Application of a new bivalent Marek's disease vaccine does not interfere with infectious bronchitis or Newcastle disease vaccinations and proves efficacious. (23901767)
2013
4
Protection conferred by a recombinant Marek's disease virus that expresses the spike protein from infectious bronchitis virus in specific pathogen-free chicken. (22559869)
2012
5
The presence of the p53 transcripts with truncated open reading frames in Marek's disease tumor-derived cell lines. (16448698)
2006
6
Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30). (15356338)
2004
7
Phenotypic variation among three broiler pure lines for Marek's disease, coccidiosis, and antibody response to sheep red blood cells. (12033413)
2002
8
The clone and comparison of very virulent plus Marek's disease virus(vv+ DMV)648 strain glycoprotein E(gE) gene]. (12549019)
2001
9
Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style. (11022789)
2000
10
Atherosclerosis in Marek's disease virus infected hypercholesterolemic roosters is reduced by HMGCoA reductase and ACE inhibitor therapy. (9683927)
1998
11
Transformation of primary chick embryo fibroblasts by Marek's disease virus. (9426443)
1997
12
The 132 bp repeats are present in RNA transcripts from 1.8 kb gene family of Marek disease virus-transformed cells. (8105666)
1993
13
Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors. (1315048)
1992
14
Transactivation of the Rous sarcoma virus long terminal repeat promoter by Marek's disease virus. (2173259)
1990
15
The structure of Marek disease virus DNA: the presence of unique expansion in nonpathogenic viral DNA. (2983314)
1985
16
Extensive homology exists between Marek disease herpesvirus and its vaccine virus, herpesvirus of turkeys. (6328512)
1984
17
Inverted repeat nucleotide sequences in the genomes of Marek disease virus and the herpesvirus of the turkey. (6281774)
1982
18
Ultrastructural comparison of morphogenesis and fate of Marek's disease and infectious laryngotracheitis viruses in chicken kidney cells. (4352713)
1973

Genetic Variations for Marek Disease

Expression for genes affiliated with Marek Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Marek Disease

Search GEO for disease gene expression data for Marek Disease.

Pathways for genes affiliated with Marek Disease

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 30KEGG, 56SinoBiological, 53R&D Systems
See all sources

Compounds for genes affiliated with Marek Disease

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Marek Disease according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1pdtc4510.5JUN
2perillyl alcohol45 2411.1JUN, HMGCR
3manidipine4510.1ACE, HMGCR
4ramipril45 1111.0ACE, HMGCR
5thiazide4510.0ACE, HMGCR
6diltiazem45 29 1112.0ACE, HMGCR
7irbesartan45 29 50 1113.0ACE, JUN
8amiodarone45 50 29 1113.0ACE, HMGCR
9amlodipine45 50 11 2412.9HMGCR, ACE
10dicoumarol459.8JUN, TP53
11sulindac sulfide459.8TP53, JUN
12serine459.8JUN, TNFRSF1B, HMGCR
13clopidogrel50 45 11 2412.8ACE, HMGCR
14cd 437459.7JUN, TP53
15butyrate459.7CRAT
16cerivastatin45 50 29 1112.7HMGCR, JUN
17radicicol45 60 1111.7JUN, TP53
18triptolide459.6JUN, TP53
19beta-naphthoflavone45 1110.6CRAT, JUN
20geldanamycin45 50 60 1112.5TP53, TNFRSF1B, JUN
21curcumin459.5TP53, TNFRSF1B, JUN
22lactacystin459.5TP53, HMGCR, JUN
23tamoxifen45 50 29 1112.3JUN, TNFRSF1B, CRAT
24aphidicolin459.3CRAT, TP53
25cyclosporin a45 29 6011.2JUN, TNFRSF8, TNFRSF1B, HMGCR
26sodium arsenite459.1TP53, JUN
2712-o-tetradecanoylphorbol 13-acetate459.1JUN, TNFRSF1B, CRAT
28vinblastine45 50 1111.0TP53, CRAT, JUN
29retinoid459.0JUN, CRAT, TP53
30etoposide45 50 60 1111.9TP53, CRAT, JUN
31threonine458.9GYPC, TNFRSF1B, TNFRSF8, JUN
32dexamethasone45 50 29 1111.9HMGCR, CRAT, TNFRSF1B, JUN
33vitamin d458.8JUN, TNFRSF1B, CRAT
34sodium45 249.7ACE, GYPC, CRAT, TNFRSF1B
35n acetylcysteine458.7JUN, CRAT, HMGCR, TP53
36paclitaxel45 50 1110.7TP53, HMGCR, CRAT
37oligonucleotide458.6JUN, TNFRSF1B, CRAT, TP53
38zinc45 249.6ACE, CRAT, TNFRSF1B, TNFRSF8
39arginine458.6TNFRSF1B, CRAT, HMGCR, TP53
40actinomycin d458.3TP53, HMGCR, CRAT, TNFRSF1B, JUN
41h2o2458.3JUN, TNFRSF1B, CRAT, HMGCR, TP53
42vegf458.3TP53, HMGCR, CRAT, TNFRSF1B, JUN
43thymidine45 249.0TP53, GYPC, CRAT, TNFRSF8, JUN
44lipid457.9TNFRSF8, TNFRSF1B, CRAT, GYPC, HMGCR, ACE

GO Terms for genes affiliated with Marek Disease

Sources:
16Gene Ontology
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Biological processes related to Marek Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cardiac muscle cell apoptotic processGO:0106669.5TP53, HMGCR
2release of cytochrome c from mitochondriaGO:0018369.4TP53, JUN
3positive regulation of neuron apoptotic processGO:0435259.4TP53, JUN
4positive regulation of smooth muscle cell proliferationGO:0486619.4HMGCR, JUN
5protein tetramerizationGO:0512629.4HMGCR, TP53

Molecular functions related to Marek Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:0050319.6TNFRSF1B, TNFRSF8

Products for genes affiliated with Marek Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Marek Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet