MCID: MRK002
MIFTS: 28

Marek Disease

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Marek Disease

MalaCards integrated aliases for Marek Disease:

Name: Marek Disease 49 69
Neurolymphomatosis 49 55
Marek's Disease 49
Fowl Paralyses 49
Fowl Paralysis 49

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Orphanet 55 ORPHA206586
UMLS 69 C0024793

Summaries for Marek Disease

MalaCards based summary : Marek Disease, also known as neurolymphomatosis, is related to lymphoma and hemorrhage, intracerebral. An important gene associated with Marek Disease is HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and MAPK Signaling: Oxidative Stress Pathway. Affiliated tissues include t cells.

Wikipedia : 72 Marek\'s disease is a highly contagious viral neoplastic disease in chickens. It is named after József... more...

Related Diseases for Marek Disease

Graphical network of the top 20 diseases related to Marek Disease:



Diseases related to Marek Disease

Symptoms & Phenotypes for Marek Disease

Drugs & Therapeutics for Marek Disease

Search Clinical Trials , NIH Clinical Center for Marek Disease

Genetic Tests for Marek Disease

Anatomical Context for Marek Disease

MalaCards organs/tissues related to Marek Disease:

38
T Cells

Publications for Marek Disease

Articles related to Marek Disease:

# Title Authors Year
1
The 132 bp repeats are present in RNA transcripts from 1.8 kb gene family of Marek disease virus-transformed cells. ( 8105666 )
1993
2
Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors. ( 1315048 )
1992
3
The structure of Marek disease virus DNA: the presence of unique expansion in nonpathogenic viral DNA. ( 2983314 )
1985
4
Extensive homology exists between Marek disease herpesvirus and its vaccine virus, herpesvirus of turkeys. ( 6328512 )
1984
5
Inverted repeat nucleotide sequences in the genomes of Marek disease virus and the herpesvirus of the turkey. ( 6281774 )
1982

Variations for Marek Disease

Expression for Marek Disease

Search GEO for disease gene expression data for Marek Disease.

Pathways for Marek Disease

GO Terms for Marek Disease

Biological processes related to Marek Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.65 JUN TNFRSF8 TP53
2 positive regulation of apoptotic process GO:0043065 9.54 JUN TNFRSF8 TP53
3 Ras protein signal transduction GO:0007265 9.46 JUN TP53
4 response to cytokine GO:0034097 9.43 JUN TP53
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.4 HMGCR JUN
6 positive regulation of neuron apoptotic process GO:0043525 9.32 JUN TP53
7 protein tetramerization GO:0051262 9.26 HMGCR TP53
8 cellular response to reactive oxygen species GO:0034614 9.16 JUN TP53
9 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.96 JUN TP53
10 aging GO:0007568 8.8 HMGCR JUN TP53

Molecular functions related to Marek Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase 2A binding GO:0051721 8.62 HMGCR TP53

Sources for Marek Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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