MCID: MRG003
MIFTS: 59

Marginal Zone B-Cell Lymphoma malady

Cancer diseases, Immune diseases categories
Download this MalaCard

Summaries for Marginal Zone B-Cell Lymphoma

About this section


Fully expand this MalaCard
Disease Ontology:8 A b-cell lymphoma that is characterized by initial formation in the marginal zones of lymph tissue.

MalaCards based summary: Marginal Zone B-Cell Lymphoma, also known as marginal zone lymphoma, is related to macroglobulinemia and mantle cell lymphoma. An important gene associated with Marginal Zone B-Cell Lymphoma is MALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1), and among its related pathways are Creation of C4 and C2 activators and TP53 network. The compounds glucuronoxylomannan and 2-methoxyestradiol have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and lung, and related mouse phenotypes are pigmentation and digestive/alimentary.

Aliases & Classifications for Marginal Zone B-Cell Lymphoma

About this section

Marginal Zone B-Cell Lymphoma, Aliases & Descriptions:

Name: Marginal Zone B-Cell Lymphoma 30 8 62
 
Marginal Zone Lymphoma 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:0050748

Related Diseases for Marginal Zone B-Cell Lymphoma

About this section

Diseases related to Marginal Zone B-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1macroglobulinemia31.7PAX5, CD5
2mantle cell lymphoma31.6CCND1, BCL6
3plasmacytoma31.5PAX5, IRF4, BCL6
4hairy cell leukemia31.2CD5, BCL6, CCND1
5hepatitis c31.1TLR4, BCL6, CD40LG
6hodgkin's lymphoma31.1PAX5, IRF4, BCL3, BCL6, BIRC3
7peripheral t-cell lymphoma31.1PAX5, BCL3, BCL6, CD5
8cryoglobulinemia31.0CD40LG, CD5
9anaplastic large cell lymphoma31.0BCL6, BCL3, PAX5
10malt lymphoma30.9CCND1, IRF4, TLR4, MALT1, BCL6, CD5
11chronic lymphocytic leukemia30.8PAX5, CCND1, BCL10, CD5
12b-cell lymphomas30.5CD5, PIM1, RB1, BIRC3, BCL10, BCL6
13multiple myeloma30.2TP53, IRF4, CCND1, CDKN2A
14follicular lymphoma30.1CD5, BIRC3, BCL10, BCL6, BCL3, CCND1
15lung adenocarcinoma30.0CDKN2A, RB1, CCND1, TP53
16myeloma29.9PAX5, IRF4, CCND1, BCL6, BIRC3, RB1
17adenocarcinoma29.9SPN, TP53, CCND1, BIRC3, RB1, CDKN2A
18melanoma29.4PIM1, TLR4, TP53, IRF4, CCND1, RB1
19leukemia28.2BCL6, BCL3, CCND1, IRF4, PAX5, TP53
20primary cutaneous marginal zone b-cell lymphoma11.2
21nodal marginal zone b-cell lymphoma11.1
22hepatitis10.9
23amyloidosis10.8
24thyroiditis10.8
25histiocytosis10.8
26arthritis10.7
27diffuse large b-cell lymphoma10.7
28rheumatoid arthritis10.7
29castleman's disease10.6
30hepatitis c virus10.6
31hemolytic anemia10.6
32lymphoplasmacytic lymphoma10.6
33gastric cancer10.5
34systemic lupus erythematosus10.5
35langerhans-cell histiocytosis10.5
36composite lymphoma10.5
37lupus erythematosus10.5
38meningioma10.5
39meningitis10.5
40autoimmune hemolytic anemia10.5
41central nervous system lymphoma10.5BCL6
42gallbladder lymphoma10.5MALT1, BCL10
43edwards syndrome10.5BCL10, MALT1
44gastric lymphoma10.4BCL10, BCL6, MALT1
45actinic keratosis10.4TP53
46scrub typhus10.4CD40LG
47hepatitis b10.4
48keratopathy10.4
49liver disease10.4
50primary biliary cirrhosis10.4

Graphical network of the top 20 diseases related to Marginal Zone B-Cell Lymphoma:



Diseases related to marginal zone b-cell lymphoma

Symptoms for Marginal Zone B-Cell Lymphoma

About this section

Drugs & Therapeutics for Marginal Zone B-Cell Lymphoma

About this section

Drug clinical trials:

Search ClinicalTrials for Marginal Zone B-Cell Lymphoma

Search NIH Clinical Center for Marginal Zone B-Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Marginal Zone B-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Marginal Zone B-Cell Lymphoma

About this section

Anatomical Context for Marginal Zone B-Cell Lymphoma

About this section

MalaCards organs/tissues related to Marginal Zone B-Cell Lymphoma:

32
B cells, Bone, Lung, Thyroid, T cells, Bone marrow, Colon, Salivary gland, Small intestine, Breast, Thymus, Skin, Uterus, Lymph node, Liver, Spleen, Brain, Spinal cord, Tonsil, Appendix

Animal Models for Marginal Zone B-Cell Lymphoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Marginal Zone B-Cell Lymphoma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.0TLR4, TP53, RB1, CDKN2A
2MP:00053818.6AIRE, TLR4, TP53, CCND1, RB1, CDKN2A
3MP:00053918.6AIRE, TLR4, TP53, CCND1, RB1, CDKN2A
4MP:00053708.5AIRE, TLR4, TP53, BCL6, RB1, CDKN2A
5MP:00107718.4CD40LG, CDKN2A, RB1, CCND1, TP53, TLR4
6MP:00053908.4TLR4, TP53, PAX5, CCND1, RB1, CDKN2A
7MP:00053888.3AIRE, TLR4, TP53, CCND1, BCL6, RB1
8MP:00053798.2AIRE, TP53, CCND1, RB1, CDKN2A, CD40LG
9MP:00030128.2AIRE, PIM1, TP53, BCL6, RB1, CD5
10MP:00053698.0TLR4, TP53, BCL6, BIRC3, RB1, CDKN2A
11MP:00053898.0AIRE, TLR4, TP53, CCND1, BCL6, RB1
12MP:00036318.0AIRE, TLR4, TP53, PAX5, CCND1, BCL10
13MP:00020067.8AIRE, SPN, TLR4, TP53, IRF4, CCND1
14MP:00053857.6TLR4, TP53, CCND1, BCL6, BIRC3, RB1
15MP:00053787.5AIRE, PIM1, TLR4, TP53, PAX5, CCND1
16MP:00028737.4AIRE, PIM1, TP53, PAX5, CCND1, BCL6
17MP:00053766.9AIRE, TLR4, TP53, CCND1, BCL3, BCL6
18MP:00107686.5CCND1, PAX5, TP53, TLR4, AIRE, BCL3
19MP:00053846.3AIRE, PIM1, TLR4, TP53, PAX5, CCND1
20MP:00053974.3AIRE, CDKN2A, CD5, RB1, RHOH, BIRC3
21MP:00053874.3AIRE, CD40LG, CDKN2A, CD5, RB1, RHOH

Publications for Marginal Zone B-Cell Lymphoma

About this section

Articles related to Marginal Zone B-Cell Lymphoma:

(show top 50)    (show all 366)
idTitleAuthorsYear
1
Nodal involvement by marginal zone B-cell lymphoma harboring t(14;22)(q32;q11) involving immunoglobulin heavy chain and light chain lambda as the sole karyotypically recognizable abnormality in a patient with systemic lupus erythematosus. (25197401)
2014
2
Nodal marginal zone B-cell lymphoma showing prominent plasma cell differentiation in the pleural effusion: A case report. (22833332)
2014
3
Crystal storing histiocytosis associated with marginal zone B-cell lymphoma: A rare initial clinical presentation diagnosed by fine-needle aspiration. (25071859)
2014
4
Rituximab plus bendamustine is active in pretreated patients with extragastric marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma). (23925930)
2014
5
Crystal-storing histiocytosis complicating marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. (25216699)
2014
6
Two Cases of Diffuse Large B-Cell Lymphomas in the Cervical Lymph Nodes in Patients with Low-Grade Gastric Marginal Zone B-Cell Lymphoma (MALT Lymphoma). (23767042)
2013
7
Is bone marrow biopsy always indicated in patients with primary cutaneous marginal zone B-cell lymphoma? (23954046)
2013
8
Subcutaneous dissemination pattern in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue lymphoma. (22180423)
2012
9
Letter: Primary cutaneous marginal zone B cell lymphoma of the face: a challenging diagnosis. (22398233)
2012
10
A case of monoclonal gammopathy in extranodal marginal zone B-cell lymphoma of the small intestine. (21239866)
2011
11
Central nervous system marginal zone B-cell lymphoma associated with Chlamydophila psittaci infection. (21239044)
2011
12
Cutaneous manifestations of B-cell chronic lymphocytic leukemia associated with Borrelia burgdorferi infection showing a marginal zone B-cell lymphoma-like infiltrate. (21946761)
2011
13
An Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast - Its Diagnosis and the Role of Radiotherapy in its Management. (22619650)
2011
14
Pulmonary marginal zone B-cell lymphoma of MALT type--what is a prognostic factor and which is the optimal treatment, operation, or chemotherapy?: Consortium for Improving Survival of Lymphoma (CISL) study. (20024551)
2010
15
CD123-positive plasmacytoid dendritic cells in primary cutaneous marginal zone B-cell lymphoma: A crucial role and a new lymphoma paradigm. (19940749)
2010
16
Primary cutaneous marginal zone B-cell lymphoma with amyloid deposition: report of two cases with review of literature. (20507739)
2010
17
Low grade marginal zone B-cell lymphoma presenting as local amyloidosis in a submandibular salivary gland. (20970706)
2010
18
A minute focus of extranodal marginal zone B-cell lymphoma arising in Hashimoto thyroiditis diagnosed with PCR after laser capture microdissection: a case report. (19735541)
2009
19
Relapsed or refractory nongastric marginal zone B-cell lymphoma: multicenter retrospective analysis of 92 cases. (19890833)
2009
20
Primary cutaneous marginal zone B-cell lymphomas are targeted by aberrant somatic hypermutation. (18704108)
2009
21
Absence of efficacy of thalidomide monotherapy in patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma). (19654203)
2009
22
Marginal zone B-cell lymphoma of bronchus-associated lymphoid tissue: imaging findings in 21 patients. (18071012)
2008
23
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue arising in the extracranial head and neck region: a high rate of dissemination and disease recurrence. (18234544)
2008
24
Thymic epithelial cells expressed unusual follicular dendritic cell markers: thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. (18477221)
2008
25
The majority of cutaneous marginal zone B-cell lymphomas expresses class-switched immunoglobulins and develops in a T-helper type 2 inflammatory environment. (18687986)
2008
26
Concurrence of marginal zone B-cell lymphoma MALT-type and Langerhans cell histiocytosis in a thyroid gland with Hashimoto disease. (18401582)
2008
27
Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma. (17947227)
2008
28
Primary cutaneous marginal zone B-cell lymphoma may exhibit both the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18)(q32;q21) IGH/MALT1 translocation: an indicator for clonal transformation towards higher-grade B-cell lymphoma? (17519619)
2007
29
Primary marginal zone B-cell lymphoma of gastrointestinal tract presenting as multiple lymphomatoid polyposis. (16586077)
2007
30
Genome-wide array-based comparative genomic hybridization of ocular marginal zone B cell lymphoma: comparison with pulmonary and nodal marginal zone B cell lymphoma. (17492759)
2007
31
Schnitzler syndrome associated with systemic marginal zone B-cell lymphoma. (16965436)
2006
32
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue arising in the lateral ventricle. (16194887)
2005
33
Cutaneous lymphoid hyperplasia and marginal zone B-cell lymphoma following vaccination. (16112365)
2005
34
Small lymphocytic lymphoma, marginal zone B-cell lymphoma, and mantle cell lymphoma exhibit distinct gene-expression profiles allowing molecular diagnosis. (14630827)
2004
35
Primary extranodal marginal zone B-cell lymphoma of MALT type of the endometrium. (15047243)
2004
36
Primary cutaneous immunocytoma/marginal zone B-cell lymphoma: a case with unusual course. (15024193)
2004
37
Hen's teeth?: Extranodal marginal zone B cell lymphoma of MALT type in nasal mucosa. (15574163)
2004
38
Nodal marginal zone B-cell lymphoma with a novel t(X;5)(q28;q22): conventional and molecular cytogenetic analysis. (12781450)
2003
39
Extranodal marginal zone B-cell lymphoma of MALT-type of the lung: single-center experience with 12 patients. (12802920)
2003
40
Rituximab for treatment of advanced extranodal marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue lymphoma. (14707449)
2003
41
API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. (12651604)
2003
42
Extranodal marginal zone B-cell lymphoma of the lacrimal gland associated with crystal-storing histiocytosis. (11772588)
2002
43
Complete remission of chronic plaque psoriasis and gastric marginal zone B-cell lymphoma of MALT type after treatment with 2-chlorodeoxyadenosine. (12454707)
2002
44
Somatic hypermutation of immunoglobulin heavy chain variable region genes in thymic marginal zone B-cell lymphoma of MALT type of a patient with SjAPgren's syndrome. (11895498)
2002
45
Hodgkin-like transformation of a marginal zone B-cell lymphoma of the larynx. (11842381)
2002
46
Marginal-zone B-cell lymphoma, extranodal-malt-type: report of three cases. (11766741)
2001
47
Gastric marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type: management of the disease. (10975767)
2000
48
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) of the sigmoid colon. (11115928)
2000
49
Somatic mutation analysis of IgH variable regions reveals that tumor cells of most parafollicular (monocytoid) B-cell lymphoma, splenic marginal zone B-cell lymphoma, and some hairy cell leukemia are composed of memory B lymphocytes. (10088550)
1999
50
B-cell lymphoma accompanying monoclonal macroglobulinemia with features suggesting marginal zone B-cell lymphoma. (9195780)
1997

Variations for Marginal Zone B-Cell Lymphoma

About this section

Expression for genes affiliated with Marginal Zone B-Cell Lymphoma

About this section
Expression patterns in normal tissues for genes affiliated with Marginal Zone B-Cell Lymphoma

Search GEO for disease gene expression data for Marginal Zone B-Cell Lymphoma.

Pathways for genes affiliated with Marginal Zone B-Cell Lymphoma

About this section

Pathways related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8BCL10, MALT1, C1S
2
Show member pathways
9.7CDKN2A, TP53
39.6PAX5, RB1, CD40LG
4
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.6IRF4, MALT1, BCL10, CD40LG
59.5CD40LG, BCL6, IRF4
69.5TLR4, IRF4, MALT1, BCL10
79.4TLR4, TP53, CCND1
8
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.4TP53, CCND1, RB1
9
Show member pathways
9.4TP53, CCND1, RB1
109.4RB1, CCND1, TP53
119.4RB1, CCND1, TP53
129.4RB1, CCND1, TP53
139.4TP53, RB1, CDKN2A
149.4CDKN2A, RB1, TP53
159.4CDKN2A, RB1, TP53
169.3PIM1, TLR4, CCND1
17
Show member pathways
Signal transduction PTEN pathway60
9.2CCND1, TP53, PIM1
189.2TP53, BCL6, RB1
19
Show member pathways
9.2BCL10, BCL3, MALT1, TLR4
209.2BCL6, BCL10, RB1, CD5
21
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1BIRC3, BCL10, MALT1, TLR4
22
Show member pathways
9.1BIRC3, TP53, TLR4
23
Show member pathways
9.1TP53, BIRC3, RB1
249.1TP53, CCND1, RB1, CDKN2A
25
Show member pathways
9.1TP53, CCND1, RB1, CDKN2A
26
Show member pathways
9.1TP53, CCND1, RB1, CDKN2A
27
Show member pathways
DNA damage response37
9.1TP53, CCND1, RB1, CDKN2A
28
Show member pathways
Cell cycle37
9.1CDKN2A, RB1, CCND1, TP53
299.1TP53, CCND1, RB1, CDKN2A
30
Show member pathways
9.1TP53, CCND1, RB1, CDKN2A
31
Show member pathways
Signaling Pathways in Glioblastoma37
9.1TP53, CCND1, RB1, CDKN2A
32
Show member pathways
9.1CDKN2A, RB1, CCND1, TP53
339.1CDKN2A, RB1, CCND1, TP53
349.0TLR4, TP53, CCND1, RB1
35
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.0TLR4, TP53, CCND1, RB1
36
Show member pathways
9.0TLR4, TP53, CCND1, MALT1, BCL10
37
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
9.0TP53, CCND1, MALT1, BCL10, RB1
38
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.0TP53, CCND1, BCL6, CDKN2A
398.9BIRC3, BCL10, MALT1, PIM1
40
Show member pathways
8.9AIRE, MALT1, BCL10, BIRC3, CD40LG
418.9PIM1, TP53, CCND1, CDKN2A
42
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
8.9CDKN2A, BIRC3, IRF4, TP53
438.9PIM1, PAX5, MALT1, BCL6, BCL10
44
Show member pathways
8.9CDKN2A, RB1, BCL10, CCND1, TP53
458.8CD40LG, BIRC3, BCL10, MALT1, TLR4
468.8BIRC3, CCND1, PAX5, PIM1
478.8TP53, CCND1, BIRC3, RB1
488.8TP53, PAX5, BCL6, BIRC3
49
Show member pathways
8.6TLR4, TP53, MALT1, BIRC3, CD40LG
508.4TP53, CCND1, BIRC3, RB1, CDKN2A

Compounds for genes affiliated with Marginal Zone B-Cell Lymphoma

About this section

Compounds related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1glucuronoxylomannan4410.0TLR4, CD40LG
22-methoxyestradiol44 61 2411.8TP53, CCND1, PAX5
3anti-fungal449.8CDKN2A, TLR4, CD40LG
4cytidine44 24 1111.8PAX5, BCL6, CD40LG
5hpvs449.8RB1, CDKN2A, TP53
6acnu449.7CDKN2A, TP53
7aflatoxin b144 2410.7TP53, CDKN2A, RB1
8hmba449.7CDKN2A, TP53, RB1
9[alcl]449.7RB1, PAX5, BCL3
10cytosine44 2410.7AIRE, RB1, CDKN2A, PAX5
11n-(4-hydroxyphenyl)retinamide449.7CCND1, TP53, RB1
12rituximab44 50 1111.6BCL6, PAX5, C1S, CD40LG
13olomoucine44 1110.5RB1, CDKN2A, TP53, CCND1
14crcs449.5TP53, RB1, CCND1, CDKN2A
15depsipeptide449.5CCND1, TP53, CDKN2A, RB1
16roscovitine449.5TP53, CDKN2A, RB1, CCND1
17flavopiridol44 1110.5RB1, CCND1, TP53, CDKN2A
18thymidylate449.5RB1, CCND1, CDKN2A, TP53
19methotrexate50 44 1111.4CDKN2A, RB1, CCND1, TLR4
20egcg449.4TP53, CCND1, RB1, CDKN2A
21bortezomib44 50 1111.4CD40LG, TP53, CCND1
22agar449.4RB1, CDKN2A, CD40LG, CCND1
23fludarabine44 50 1111.4BIRC3, TP53, CD40LG
24n acetylcysteine449.2CCND1, CD40LG, CDKN2A, TLR4, TP53
25genistein44 28 61 2 24 1114.2TLR4, CCND1, CD40LG, CDKN2A, RB1
26mg 13244 6110.2BIRC3, TP53, CDKN2A, CCND1
27butyrate449.1TP53, CDKN2A, RB1, CCND1
28vincristine44 50 1111.0BCL6, CDKN2A, RB1, TP53, CCND1
295fluorouracil449.0TP53, RB1, CDKN2A, BIRC3
30testosterone44 61 24 1112.0RB1, PAX5, CDKN2A, CCND1, CD40LG
31adriamycin448.9CDKN2A, RB1, BIRC3, CCND1, TP53
32rapamycin448.9PIM1, CCND1, BCL3, RB1, CD40LG
33pdtc448.8TP53, BIRC3, TLR4
34ly294002448.8TP53, CCND1, RB1, BIRC3, TLR4
35vegf448.8CDKN2A, TLR4, RB1, CCND1, TP53, CD40LG
36sb 20358044 619.6BIRC3, TP53, RB1, TLR4, AIRE, CCND1
37oligonucleotide448.6CDKN2A, RB1, PAX5, CCND1, BIRC3, TP53
38estrogen448.6TP53, CD40LG, RB1, BCL6, CCND1, CDKN2A
39actinomycin d448.5CD40LG, CDKN2A, RB1, BIRC3, TP53, TLR4
40paclitaxel44 50 1110.5RB1, BIRC3, CDKN2A, TP53, TLR4, CCND1
41alanine448.5PIM1, BIRC3, CDKN2A, BCL10, TLR4, CD40LG
42cycloheximide448.4CDKN2A, TP53, TLR4, CCND1, BCL6, BIRC3
43h2o2448.3SPN, TLR4, TP53, CDKN2A, RB1
44cisplatin44 50 61 1111.3RB1, BIRC3, CDKN2A, CD40LG, TLR4, CCND1
45doxorubicin44 50 1110.2CD40LG, CDKN2A, CCND1, RB1, BIRC3, BCL6
46retinoic acid44 248.6CDKN2A, RB1, CD40LG, CCND1, TP53, TLR4
47paraffin447.3CD40LG, MALT1, BCL6, RB1, CD5, CDKN2A
48calcium44 50 24 1110.1PAX5, TLR4, BIRC3, RB1, CD5, CDKN2A
49tyrosine446.0RB1, AIRE, SPN, CD5, BIRC3, BCL6
50serine445.5BIRC3, RB1, CDKN2A, CD40LG, BCL6, CCND1

GO Terms for genes affiliated with Marginal Zone B-Cell Lymphoma

About this section

Cellular components related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CBM complexGO:03244910.2BCL10, MALT1
2immunological synapseGO:00177210.1RHOH, BCL10
3lipopolysaccharide receptor complexGO:04669610.0BCL10, TLR4
4replication forkGO:0056579.3BCL6, TP53
5external side of plasma membraneGO:0098978.9SPN, TLR4, CD5, CD40LG
6protein complexGO:0432348.4CDKN2A, BIRC3, BCL10, BCL3, MALT1, TP53
7cytosolGO:0058297.9TP53, IRF4, CCND1, MALT1, BCL10, BIRC3
8cytoplasmGO:0057376.9AIRE, PIM1, TLR4, TP53, MALT1, BCL3
9nucleusGO:0056346.0IRF4, PAX5, TP53, PIM1, AIRE, CCND1

Biological processes related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell receptor signaling pathwayGO:05085610.5BCL10, MALT1
2response to fungusGO:00962010.5MALT1, BCL10
3response to molecule of bacterial originGO:00223710.4MALT1, BCL10
4positive regulation of interleukin-8 biosynthetic processGO:04541610.3TLR4, BCL10
5positive regulation of T cell activationGO:05087010.3BCL10, MALT1
6positive regulation of interleukin-10 biosynthetic processGO:04508210.1BCL3, IRF4
7mitotic G1 DNA damage checkpointGO:03157110.1CCND1, TP53
8cell cycle checkpointGO:00007510.1CDKN2A, RB1
9replicative senescenceGO:09039910.0TP53, CDKN2A
10negative regulation of cell-matrix adhesionGO:0019539.9BCL6, CDKN2A
11T-helper 1 type immune responseGO:0420889.9BCL3, TLR4
12positive regulation of NF-kappaB transcription factor activityGO:0510929.9TLR4, MALT1, BCL10
13defense response to protozoanGO:0428329.9BCL3, IRF4
14germinal center formationGO:0024679.9BCL3, BCL6
15positive regulation of interleukin-12 productionGO:0327359.8CD40LG, TLR4
16positive regulation of protein ubiquitinationGO:0313989.8BIRC3, BCL10, MALT1
17DNA damage response, signal transduction by p53 class mediatorGO:0303309.8TP53, BCL3
18negative regulation of reactive oxygen species metabolic processGO:20003789.8BIRC3, TP53
19positive regulation of cell cycle arrestGO:0711589.7TP53, CDKN2A
20Ras protein signal transductionGO:0072659.7CDKN2A, RB1, TP53
21negative regulation of phosphorylationGO:0423269.7CDKN2A, RHOH, BIRC3
22response to X-rayGO:0101659.7CCND1, TP53
23positive regulation of tumor necrosis factor biosynthetic processGO:0425359.6TLR4, SPN
24toll-like receptor signaling pathwayGO:0022249.5TLR4, BCL10, BIRC3
25positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.5BIRC3, BCL10, MALT1, TLR4
26protein import into nucleus, translocationGO:0000609.5TP53, BCL3, BCL6
27negative regulation of cell growthGO:0303089.5CDKN2A, BCL6, TP53
28cell cycle arrestGO:0070509.4CDKN2A, RB1, TP53
29innate immune responseGO:0450879.2BIRC3, BCL10, MALT1, TLR4, C1S
30G1/S transition of mitotic cell cycleGO:0000829.2CDKN2A, RB1, CCND1
31cellular response to DNA damage stimulusGO:0069749.2TP53, CCND1, BCL3, BCL6
32regulation of apoptotic processGO:0429819.1TP53, MALT1, BCL3, BIRC3
33defense response to bacteriumGO:0427429.1SPN, TLR4, BCL3
34negative regulation of transcription, DNA-templatedGO:0458928.8TP53, BCL3, BCL6, RB1, CDKN2A
35positive regulation of transcription, DNA-templatedGO:0458938.6AIRE, TP53, IRF4, BCL3, BCL10, RB1
36transcription, DNA-templatedGO:0063518.4AIRE, IRF4, CCND1, BCL3, BCL6, RB1
37negative regulation of apoptotic processGO:0430668.3PIM1, TP53, MALT1, BCL3, BIRC3, CD40LG
38positive regulation of transcription from RNA polymerase II promoterGO:0459448.2CDKN2A, AIRE, TLR4, TP53, PAX5, IRF4

Molecular functions related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1kinase activator activityGO:01920910.2BCL10, MALT1
2NF-kappaB bindingGO:05105910.0CDKN2A, BCL10
3MDM2/MDM4 family protein bindingGO:0973719.9CDKN2A, TP53
4protease bindingGO:0020209.8TP53, MALT1, BCL10
5ubiquitin protein ligase bindingGO:0316259.4RB1, BCL10, TP53
6protein kinase bindingGO:0199019.3CDKN2A, BCL10, CCND1, TP53
7transmembrane signaling receptor activityGO:0048889.1SPN, TLR4, CD5
8identical protein bindingGO:0428028.9AIRE, C1S, TP53, RB1
9sequence-specific DNA binding transcription factor activityGO:0037008.4TP53, PAX5, IRF4, BCL3, BCL6, RB1
10transcription factor bindingGO:0081347.9CDKN2A, PIM1, TP53, IRF4, CCND1, BCL3
11protein bindingGO:0055154.4IRF4, TP53, TLR4, C1S, PIM1, SPN

Products for genes affiliated with Marginal Zone B-Cell Lymphoma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Marginal Zone B-Cell Lymphoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet