MCID: MRG003
MIFTS: 43

Marginal Zone B-Cell Lymphoma malady

Summaries for Marginal Zone B-Cell Lymphoma

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A b-cell lymphocytic neoplasm presenting primarily in the marginal zone.

MalaCards: Marginal Zone B-Cell Lymphoma is related to gastric lymphoma and amyloidosis. An important gene associated with Marginal Zone B-Cell Lymphoma is BCL10 (B-cell CLL/lymphoma 10), and among its related pathways are IL4-mediated signaling events and Primary immunodeficiency. The compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Marginal Zone B-Cell Lymphoma

Sources:
8Disease Ontology, 31LifeMap Discovery™, 61UMLS
See all sources

Aliases & Descriptions:

marginal zone b-cell lymphoma 8 31 61


External Ids:

Disease Ontology8 DOID:0050748

Related Diseases for Marginal Zone B-Cell Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Marginal Zone B-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1gastric lymphoma31.6BCL6, MALT1, BCL10
2amyloidosis31.1CD79A
3follicular lymphoma31.1CCND1, IRF4, CD5, BIRC3, PAX5, BCL6
4b-cell lymphomas31.0BCL10, BCL3, CCND1, IRF4, PIM1, MALT1
5central nervous system lymphoma31.0BCL6
6mantle cell lymphoma31.0CCND1, BCL6
7arthritis31.0TLR4
8macroglobulinemia30.9CD5, PAX5, CD79A
9hepatitis c30.9BCL6, TLR4, CD40LG
10thyroiditis30.7CD79A
11central nervous system lymphoma, primary30.7BCL6, PIM1, PAX5
12peripheral t-cell lymphoma30.7BCL3, PAX5, BCL6, CD5
13adenocarcinoma30.7SPN, BIRC3, CDKN2A, MAD2L1, CCND1
14lymphoma, malt, somatic30.7TLR4, MALT1, CD5, BIRC3, BCL6, BCL10
15sinusitis30.5CD79A
16anaplastic large cell lymphoma30.5BCL3, PAX5, BCL6
17hepatitis b30.5CD79A, TLR4
18cryoglobulinemia30.5CD5, CD79A, CD40LG
19b-cell chronic lymphocytic leukemia30.5CCND1, CD5, PAX5, BCL10
20primary biliary cirrhosis30.5AIRE, CD40LG, CD79A
21systemic lupus erythematosus30.5CD79A, C1S, CD40LG, TLR4
22splenic marginal zone lymphoma11.0
23lung lymphoma10.8
24primary cutaneous marginal zone b-cell lymphoma10.8
25thyroid lymphoma10.7
26bone lymphoma10.7
27nodal marginal zone b-cell lymphoma10.7
28colon lymphoma10.7
29composite lymphoma10.7
30lymphoma, diffuse large cell10.7
31gastrointestinal lymphoma10.7
32orbit lymphoma10.7
33breast lymphoma10.7
34small intestine lymphoma10.7
35lymphoma, somatic10.7
36primary pulmonary lymphoma10.7
37thymus lymphoma10.6
38pediatric lymphoma10.6
39hepatitis c virus10.6
40liver lymphoma10.5
41hepatitis d10.5
42adult lymphoma10.5
43n syndrome10.5
44t-cell leukemia10.5
45leukemia/lymphoma, t-cell10.5
46primary bone lymphoma10.5
47fibrous meningioma10.4
48schnitzler syndrome10.4
49tracheal stenosis10.4
50appendix lymphoma10.4

Graphical network of the top 20 diseases related to Marginal Zone B-Cell Lymphoma:



Diseases related to marginal zone b-cell lymphoma

Clinical Features for Marginal Zone B-Cell Lymphoma

Drugs & Therapeutics for Marginal Zone B-Cell Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Marginal Zone B-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Marginal Zone B-Cell Lymphoma

Search NIH Clinical Center for Marginal Zone B-Cell Lymphoma

Search CenterWatch for Marginal Zone B-Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Marginal Zone B-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Marginal Zone B-Cell Lymphoma

Anatomical Context for Marginal Zone B-Cell Lymphoma

Animal Models for Marginal Zone B-Cell Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Marginal Zone B-Cell Lymphoma

Sources:
51PubMed
See all sources

Articles related to Marginal Zone B-Cell Lymphoma:

(show top 50)    (show all 59)
idTitleAuthorsYear
1
Rituximab plus bendamustine is active in pretreated patients with extragastric marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma). (23925930)
2014
2
Is bone marrow biopsy always indicated in patients with primary cutaneous marginal zone B-cell lymphoma? (23954046)
2013
3
Primary endobronchial marginal zone B-cell lymphoma of bronchus-associated lymphoid tissue: CT findings in 7 patients. (23483549)
2013
4
Central nervous system marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type involving the brain and spinal cord parenchyma. (22994302)
2013
5
Primary extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type in the central nervous system (MZL CNS) presented as traumatic subdural hematoma and subarachnoid bleeding - case report. (23557903)
2013
6
Development of Bullous Disease during Treatment of Pulmonary Marginal Zone B-Cell Lymphoma. (22970399)
2012
7
Coexistence of Epstein-Barr virus-associated lymphoproliferative disorder and marginal zone B-cell lymphoma of the thymus in a patient with rheumatoid arthritis treated with methotrexate. (22958131)
2012
8
Chlamydia psittaci-negative ocular adnexal marginal zone B-cell lymphomas have biased VH4-34 immunoglobulin gene expression and proliferate in a distinct inflammatory environment. (22382892)
2012
9
First report of nodal marginal zone B-cell lymphoma associated with breast implants. (22374026)
2012
10
Cutaneous manifestations of B-cell chronic lymphocytic leukemia associated with Borrelia burgdorferi infection showing a marginal zone B-cell lymphoma-like infiltrate. (21946761)
2011
11
An Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast - Its Diagnosis and the Role of Radiotherapy in its Management. (22619650)
2011
12
De novo large B-cell lymphoma in a parenchymal brain lesion: evidence of clonal evolution from splenic marginal zone lymphoma. (21205746)
2011
13
BCL6 gene rearrangement and protein expression are associated with large cell presentation of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. (20830719)
2011
14
Discordant lymphoma consisting of splenic mantle cell lymphoma and marginal zone lymphoma involving the bone marrow and peripheral blood: a case report. (21943040)
2011
15
Identification of proteomic signatures of mantle cell lymphoma, small lymphocytic lymphoma, and marginal zone lymphoma biopsies by surface enhanced laser desorption/ionization-time of flight mass spectrometry. (21438832)
2011
16
Bilateral conjunctival extranodal marginal zone B-cell lymphoma. (20981695)
2010
17
Multicenter randomized phase II study of weekly or twice-weekly bortezomib plus rituximab in patients with relapsed or refractory follicular or marginal-zone B-cell lymphoma. (19770386)
2009
18
Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma. (19696203)
2009
19
Bone marrow histology in marginal zone B-cell lymphomas: correlation with clinical parameters and flow cytometry in 120 patients. (18718888)
2009
20
Marginal zone B-cell lymphoma arising in donor cells in a Hepatitis-C virus infected patient over 20 years after allogeneic bone marrow transplantation. (19021068)
2008
21
Extranodal marginal zone B-cell mucosa-associated lymphoid tissue (MALT) lymphoma of cecum presenting as bright red bleed per rectum--a case report with review of literature. (19225911)
2008
22
Marginal-zone B-cell lymphoma of the bony palate presenting as sinusitis. (18357945)
2008
23
Asymptomatic bone marrow involvement in patients presenting with cutaneous marginal zone B-cell lymphoma. (18547317)
2008
24
Chromosomal aberrations in a case of synchronous extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type and bronchogenic adenocarcinoma. (18301237)
2008
25
Marginal zone B-cell lymphoma arising from buccal mucosa resembling inflammatory myofibroblastic tumor of the soft tissue. (20614318)
2008
26
Genome-wide array-based comparative genomic hybridization of ocular marginal zone B cell lymphoma: comparison with pulmonary and nodal marginal zone B cell lymphoma. (17492759)
2007
27
Risk of second cancer in nongastric marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue: a population-based study from northern Italy. (17200353)
2007
28
Transcriptional profiling suggests that secondary and primary large B-cell lymphomas of the gastrointestinal (GI) tract are blastic variants of GI marginal zone lymphoma. (17152084)
2007
29
Spontaneous regression of bilateral conjunctival extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. (18040147)
2007
30
Primary cutaneous marginal zone B-cell lymphoma infiltrating the frontal bone. (17324846)
2007
31
Borrelia burgdorferi-associated primary cutaneous marginal-zone B-cell lymphoma: a case report. (17823520)
2007
32
Aberrant nuclear BCL10 expression and lack of t(11;18)(q21;q21) in primary cutaneous marginal zone B-cell lymphoma. (16784987)
2006
33
Cutaneous marginal zone B-cell lymphoma in the setting of fluoxetine therapy: a hypothesis regarding pathogenesis based on in vitro suppression of T-cell-proliferative response. (16872479)
2006
34
Orbital marginal zone B-cell lymphoma of MALT: radiotherapy results and clinical behavior. (16503386)
2006
35
CD20+ nodal marginal zone B-cell lymphoma with CD20-recurrence as an intracranial dural-based mass. (17071504)
2006
36
Diagnosis of a primary uveal extranodal marginal zone B-cell lymphoma by chorioretinal biopsy: case report. (15586289)
2005
37
Splenic marginal zone lymphoma presenting as myelofibrosis associated with bone marrow involvement of lymphoma cells which secrete a large amount of TGF-beta. (15060752)
2004
38
Primary lymphoma of the breast: a case of marginal zone B-cell lymphoma. (15328808)
2004
39
Genomic abnormalities acquired in the blastic transformation of splenic marginal zone B-cell lymphoma. (12688315)
2003
40
Burkitt lymphoma following splenic marginal zone lymphoma. evidence for two independent B-cell clones. (12581905)
2003
41
Extranodal marginal zone B cell lymphoma of MALT type involving the mucosa of both the urinary bladder and stomach. (12101213)
2002
42
Blastic transformation of splenic marginal zone B-cell lymphoma. (10782161)
2000
43
Marginal zone B-cell lymphomas (MZBL) arising at different sites represent different biological entities. (10862046)
2000
44
Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. (11066071)
2000
45
Eradication of Borrelia burgdorferi infection in primary marginal zone B-cell lymphoma of the skin. (10685647)
2000
46
Primary hepatic marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type in a patient with primary biliary cirrhosis. (10747320)
2000
47
Splenic involvement by blastic mantle cell lymphoma (large cell/anaplastic variant) mimicking splenic marginal zone lymphoma. (10589081)
1999
48
BCL6 gene rearrangements also occur in marginal zone B-cell lymphoma. (9332330)
1997
49
Trisomy 3 in marginal zone B-cell lymphoma: a study based on cytogenetic analysis and fluorescence in situ hybridization. (8611468)
1996
50
"Small" B-cell non-Hodgkin's lymphomas with splenomegaly at presentation are either mantle cell lymphoma or marginal zone cell lymphoma. A study based on histology, cytology, immunohistochemistry, and cytogenetic analysis. (8554111)
1996

Genetic Variations for Marginal Zone B-Cell Lymphoma

Expression for genes affiliated with Marginal Zone B-Cell Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Marginal Zone B-Cell Lymphoma

Search GEO for disease gene expression data for Marginal Zone B-Cell Lymphoma.

Pathways for genes affiliated with Marginal Zone B-Cell Lymphoma

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome, 52QIAGEN, 53R&D Systems, 4Cell Signaling Technology, 56SinoBiological
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Pathways related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IRF4, CD40LG
210.0CD79A, AIRE
39.8BCL10, TNFAIP3, MALT1
4
Hide members
9.8MALT1, BCL10, CD40LG
59.7BIRC3, TNFAIP3, CD40LG
69.7CCND1, TLR4, PIM1
79.6CD79A, CD5, BCL6, BCL10
89.5TNFAIP3, BCL3, BIRC3
9
Hide members
9.5BCL10, BIRC3, TLR4, MALT1
109.4TNFAIP3, IRF4, TLR4, MALT1, BCL10
11
Hide members
9.4CD79A, IRF4, MALT1, CD40LG, BCL10
129.4PIM1, BIRC3, CCND1, PAX5
13
Hide members
9.3TLR4, CCND1, MALT1, CD79A, BCL10
14
Hide members
9.2TNFAIP3, BCL3, MALT1, BCL10, TLR4
15
Hide members
9.2TNFAIP3, BIRC3, CD40LG, MALT1, TLR4
169.2PIM1, TNFAIP3, MALT1, BIRC3, BCL10
179.0CD40LG, BIRC3, BCL10, MALT1, TLR4, TNFAIP3
189.0MALT1, BCL10, PIM1, CD79A, BCL6, PAX5
19
Hide members
8.6C1S, TLR4, MALT1, TNFAIP3, BIRC3, CD79A

Compounds for genes affiliated with Marginal Zone B-Cell Lymphoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4510.4CD40LG, CD79A
2sandoglobulin4510.3CD40LG, CD79A
3glucuronoxylomannan4510.3CD40LG, TLR4
4paclitaxel45 50 1112.3CCND1, CDKN2A
5doxycycline45 1111.3CD40LG, CD79A
6vancomycin45 1111.2CD79A, CD40LG
7pneumococcal4510.2CD79A, CD40LG, TLR4
8mannan4510.1CD79A, CD40LG, TLR4
9allergens4510.0TLR4, CD40LG, CD79A
10blys4510.0CD79A, CD40LG
11cytidine45 11 2411.9CD40LG, CD79A, PAX5, BCL6
12anti-fungal459.9TLR4, CDKN2A, CD40LG, CD79A
13aspirin45 50 29 2412.9CD79A, CD40LG, TLR4, C1S
14thalidomide45 50 60 1112.8BIRC3, CD40LG, CCND1
15vincristine45 50 1111.8BCL6, CDKN2A, MAD2L1, CCND1
16folate459.8CCND1, CDKN2A, CD40LG, CD79A
17agar459.7CD79A, CD40LG, CDKN2A, CCND1
18rituximab45 50 1111.7C1S, CD40LG, CD79A, PAX5, BCL6
19sb 20358045 6010.7CCND1, TLR4, AIRE, BIRC3
20fibrinogen459.6C1S, TLR4, CD40LG, CD79A
21n acetylcysteine459.6CD79A, CD40LG, CDKN2A, TLR4, CCND1
22cytosine45 2410.5PAX5, CDKN2A, AIRE
23polysaccharide459.5TLR4, CD40LG, CD79A, SPN
24serine459.4CCND1, TLR4, PIM1, MAD2L1, BIRC3, BCL10
25doxorubicin45 50 1111.4BCL6, BIRC3, CD40LG, CDKN2A, CCND1
26cisplatin45 50 60 1112.4CCND1, TLR4, MAD2L1, CDKN2A, CD40LG, BIRC3
27rapamycin459.3BCL3, CD40LG, PIM1, CCND1
28h2o2459.2SPN, CD79A, CDKN2A, TNFAIP3, TLR4
29testosterone45 60 11 2412.2CCND1, CDKN2A, CD40LG, CD79A, PAX5
30alanine459.1TLR4, PIM1, CDKN2A, CD40LG, CD79A, BIRC3
31retinoic acid45 249.9BCL6, SPN, CD79A, CD40LG, CDKN2A, TLR4
32paraffin458.5BCL6, CCND1, MALT1, CD5, CDKN2A, CD40LG
33tyrosine457.9CCND1, TLR4, PIM1, RHOH, AIRE, CD5

GO Terms for genes affiliated with Marginal Zone B-Cell Lymphoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor complexGO:04669610.2TLR4, BCL10
2CBM complexGO:03244910.2BCL10, MALT1
3protein complexGO:0432349.5BCL10, BCL3, CDKN2A, MALT1
4external side of plasma membraneGO:0098979.4SPN, CD79A, CD40LG, CD5, TLR4
5perinuclear region of cytoplasmGO:0484719.3TLR4, MALT1, MAD2L1, BCL3, BCL10
6cytosolGO:0058298.4CCND1, TNFAIP3, IRF4, RHOH, MALT1, MAD2L1
7plasma membraneGO:0058868.1PIM1, RHOH, AIRE, MALT1, CD5, CD40LG
8cytoplasmGO:0057377.5TLR4, TNFAIP3, IRF4, PIM1, RHOH, AIRE
9nucleusGO:0056347.4AIRE, PIM1, IRF4, TNFAIP3, CCND1, MALT1

Biological processes related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell receptor signaling pathwayGO:05085610.4BCL10, MALT1
2positive regulation of interleukin-8 biosynthetic processGO:04541610.3BCL10, TLR4
3positive regulation of interleukin-10 biosynthetic processGO:04508210.3BCL3, IRF4
4response to fungusGO:00962010.3BCL10, MALT1
5regulation of germinal center formationGO:00263410.3BCL6, TNFAIP3
6response to molecule of bacterial originGO:00223710.2BCL10, MALT1, TNFAIP3
7protein oligomerizationGO:05125910.1BCL10, MALT1, TNFAIP3
8B cell proliferationGO:04210010.1CD79A, CD40LG
9negative regulation of cell-matrix adhesionGO:00195310.1BCL6, CDKN2A
10negative regulation of phosphorylationGO:04232610.1RHOH, CDKN2A, BIRC3
11germinal center formationGO:00246710.0BCL3, BCL6
12I-kappaB kinase/NF-kappaB cascadeGO:00724910.0BCL10, BCL3, TLR4
13positive regulation of tumor necrosis factor biosynthetic processGO:04253510.0TLR4, SPN
14B cell differentiationGO:03018310.0CD40LG, CD79A, BCL6
15T-helper 1 type immune responseGO:0420889.9BCL3, TLR4
16positive regulation of T cell activationGO:0508709.9BCL10, MALT1
17positive regulation of NF-kappaB transcription factor activityGO:0510929.8BCL10, MALT1, TLR4
18positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.8TLR4, MALT1, BIRC3, BCL10
19positive regulation of transcription, DNA-dependentGO:0458939.6IRF4, AIRE, CDKN2A, BCL3, BCL10
20defense response to bacteriumGO:0427429.5TLR4, SPN, BCL3
21toll-like receptor signaling pathwayGO:0022249.5BCL10, BIRC3, TLR4
22innate immune responseGO:0450879.4C1S, TLR4, TNFAIP3, MALT1, BIRC3, BCL10
23positive regulation of transcription from RNA polymerase II promoterGO:0459449.4BCL3, PAX5, CDKN2A, AIRE, IRF4, TLR4
24negative regulation of apoptotic processGO:0430668.9BCL3, TNFAIP3, PIM1, MALT1, MAD2L1, CD40LG

Molecular functions related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activator activityGO:01920910.0BCL10, MALT1
2protein self-associationGO:0436219.7TNFAIP3, MALT1, BCL10
3protease bindingGO:0020209.5BCL10, MALT1, TNFAIP3
4transmembrane signaling receptor activityGO:0048889.4SPN, CD79A, CD5, TLR4
5transcription factor bindingGO:0081349.3IRF4, PIM1, CDKN2A, BCL3, BCL10
6protein bindingGO:0055156.8BCL10, C1S, CCND1, TLR4, TNFAIP3, IRF4

Products for genes affiliated with Marginal Zone B-Cell Lymphoma

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Sources for Marginal Zone B-Cell Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet