MCID: MRG003
MIFTS: 53

Marginal Zone B-Cell Lymphoma malady

Immune diseases category

Summaries for Marginal Zone B-Cell Lymphoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A b-cell lymphocytic neoplasm presenting primarily in the marginal zone.

MalaCards: Marginal Zone B-Cell Lymphoma is related to gastric lymphoma and hepatitis. An important gene associated with Marginal Zone B-Cell Lymphoma is BCL10 (B-cell CLL/lymphoma 10), and among its related pathways are IL4-mediated signaling events and Primary immunodeficiency. The compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and lung, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Marginal Zone B-Cell Lymphoma

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8Disease Ontology, 30LifeMap Discovery™, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

marginal zone b-cell lymphoma 8 30 60


External Ids:

Disease Ontology8 DOID:0050748

Related Diseases for Marginal Zone B-Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Marginal Zone B-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1gastric lymphoma31.5BCL10, BCL6, MALT1
2hepatitis31.2AIRE, CD40LG
3hepatitis b31.2TLR4, CD79A
4amyloidosis31.1CD79A
5thyroiditis31.1CD79A
6central nervous system lymphoma31.0BCL6
7mantle cell lymphoma31.0BCL6, CCND1
8hodgkin's lymphoma31.0IRF4, BIRC3, PAX5, BCL6, BCL3
9arthritis30.9TLR4
10macroglobulinemia30.9CD5, CD79A, PAX5
11rheumatoid arthritis30.9C1S, TLR4, TNFAIP3, CD5, CD40LG, CD79A
12plasmacytoma30.8IRF4, CD79A, PAX5, BCL6
13hepatitis c30.8TLR4, CD40LG, BCL6
14leukemia30.8BCL10, CCND1, TLR4, IRF4, PIM1, CD5
15hairy cell leukemia30.7CCND1, CD5, BCL6
16adenocarcinoma30.7CCND1, MAD2L1, CDKN2A, BIRC3, SPN
17malt lymphoma30.7CCND1, TLR4, IRF4, MALT1, CD5, BIRC3
18tonsillitis30.5CD79A
19anaplastic large cell lymphoma30.5BCL3, BCL6, PAX5
20cryoglobulinemia30.5CD5, CD40LG, CD79A
21lupus erythematosus30.5CD79A, CD40LG, C1S
22primary biliary cirrhosis30.5CD79A, CD40LG, AIRE
23systemic lupus erythematosus30.4C1S, TLR4, CD40LG, CD79A
24melanoma30.4CCND1, TLR4, IRF4, PIM1, CDKN2A
25myeloma30.4BIRC3, PAX5, BCL6, CD79A, CD40LG, IRF4
26chronic lymphocytic leukemia30.4CCND1, CD5, CD40LG, BIRC3, PAX5, BCL6
27splenic marginal zone lymphoma11.0
28lung lymphoma10.8
29thyroid lymphoma10.7
30bone lymphoma10.7
31colon lymphoma10.7
32diffuse large b-cell lymphoma10.7
33hepatitis a10.7
34gastrointestinal lymphoma10.6
35orbit lymphoma10.6
36composite lymphoma10.6
37breast lymphoma10.6
38small intestine lymphoma10.6
39cutaneous t cell lymphoma10.6
40histiocytosis10.6
41thymus lymphoma10.6
42pediatric lymphoma10.6
43primary cutaneous marginal zone b-cell lymphoma10.6
44liver lymphoma10.5
45adult lymphoma10.5
46b cell deficiency10.5
47cell type cancer10.5
48intestinal disease10.5
49langerhans-cell histiocytosis10.5
50meningioma10.5

Graphical network of the top 20 diseases related to Marginal Zone B-Cell Lymphoma:



Diseases related to marginal zone b-cell lymphoma

Clinical Features for Marginal Zone B-Cell Lymphoma

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Drugs & Therapeutics for Marginal Zone B-Cell Lymphoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Marginal Zone B-Cell Lymphoma

Drug clinical trials:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Marginal Zone B-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Marginal Zone B-Cell Lymphoma

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Anatomical Context for Marginal Zone B-Cell Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Marginal Zone B-Cell Lymphoma:

32
B cells, Bone, Lung, T cells, Bone marrow, Thyroid, Colon, Salivary gland, Small intestine, Breast, Skin, Thymus, Uterus, Lymph node, Brain, Liver, Spleen, Spinal cord, Tonsil, Appendix

Animal Models for Marginal Zone B-Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Marginal Zone B-Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.2CCND1, AIRE, MAD2L1, CDKN2A, SPN
2MP:00030128.5TNFAIP3, PIM1, AIRE, CD5, CDKN2A, CD79A
3MP:00053767.8TLR4, TNFAIP3, AIRE, CDKN2A, CD40LG, CD79A
4MP:00107687.5CCND1, TLR4, TNFAIP3, AIRE, MAD2L1, CDKN2A
5MP:00053975.9CCND1, SPN, BCL6, BCL3, BCL10, PAX5
6MP:00053875.9CCND1, TLR4, TNFAIP3, IRF4, PIM1, RHOH
7MP:00053845.9MALT1, MAD2L1, CD5, CDKN2A, CD40LG, CD79A

Publications for Marginal Zone B-Cell Lymphoma

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50PubMed
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Articles related to Marginal Zone B-Cell Lymphoma:

(show top 50)    (show all 381)
idTitleAuthorsYear
1
Rituximab plus bendamustine is active in pretreated patients with extragastric marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma). (23925930)
2014
2
Concurrent Lung Squamous Cell Carcinoma and Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-associated Lymphoid Tissue Type. (24419198)
2014
3
Primary cutaneous marginal zone B-cell lymphoma: response to treatment and disease-free survival in a series of 137 patients. (23796549)
2013
4
Treatment of gastric marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue with rituximab, cyclophosphamide, vincristine and prednisone. (24123108)
2013
5
Diffuse large B-cell lymphoma of the uterus suspected of having transformed from a marginal zone B-cell lymphoma harboring trisomy 18: a case report and review of the literature. (24294388)
2013
6
Subcutaneous dissemination pattern in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue lymphoma. (22180423)
2012
7
CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung. (22333190)
2012
8
Bi-clonal, multifocal primary cutaneous marginal zone B-cell lymphoma: report of a case and review of the literature. (22809282)
2012
9
De novo large B-cell lymphoma in a parenchymal brain lesion: evidence of clonal evolution from splenic marginal zone lymphoma. (21205746)
2011
10
Low grade marginal zone B-cell lymphoma presenting as local amyloidosis in a submandibular salivary gland. (20970706)
2010
11
Red nose: primary cutaneous marginal zone B-cell lymphoma. (19945162)
2010
12
Relapsed or refractory nongastric marginal zone B-cell lymphoma: multicenter retrospective analysis of 92 cases. (19890833)
2009
13
Absence of efficacy of thalidomide monotherapy in patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma). (19654203)
2009
14
Primary intracranial meningeal marginal zone B cell lymphoma of malt type (PMML) with osseous infiltration. (19052746)
2009
15
Splenic marginal zone B-cell lymphoma in a HIV-positive patient: a case report. (18709501)
2009
16
Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas. (19608670)
2009
17
Platelet satellitism and lympho-agglutination as presenting finding in marginal zone B-cell lymphoma. (19187274)
2009
18
Gastric extranodal marginal zone B-cell lymphomas of MALT type exclusively express Toll-like receptor 4 in contrast to other lymphomas infiltrating the stomach. (18042837)
2008
19
A novel radiological appearance of meningeal extranodal marginal-zone B-cell lymphoma. (18068796)
2008
20
Chromosomal aberrations in a case of synchronous extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type and bronchogenic adenocarcinoma. (18301237)
2008
21
Marginal zone B-cell lymphoma arising from buccal mucosa resembling inflammatory myofibroblastic tumor of the soft tissue. (20614318)
2008
22
Pulmonary localized AA type amyloidosis with cyst-like structures and marginal zone B-cell lymphoma of the MALT type coexisting independently in the left upper lung. (18758129)
2008
23
Primary marginal zone B-cell lymphoma of gastrointestinal tract presenting as multiple lymphomatoid polyposis. (16586077)
2007
24
Risk of second cancer in nongastric marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue: a population-based study from northern Italy. (17200353)
2007
25
Primary cutaneous CD5+ marginal zone B-cell lymphoma resembling the plasma cell variant of Castleman's disease. Case report. (18184415)
2007
26
Marginal zone B cell lymphoma of the head and neck area with associated infiltration to the subgaleal layer: case report. (17290935)
2007
27
Marginal zone B-cell lymphoma of the uterus: a case report and review of the literature. (16703935)
2006
28
Nongastric marginal-zone B-cell MALT lymphoma: prognostic value of disease dissemination. (16549813)
2006
29
Extranodal marginal zone B-cell lymphoma mimicking meningioma in lateral ventricle: a case report and possible pathogenesis. (16628474)
2006
30
Metachronous extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and peripheral T-cell lymphoma unspecified: histologic, immunophenotypic, and molecular documentation. (16160405)
2005
31
Extranodal marginal zone B-cell lymphoma of MALT-type of the lung: single-center experience with 12 patients. (12802920)
2003
32
Treatment of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with mitoxantrone, chlorambucil and prednisone (MCP). (14630681)
2003
33
Clinicopathologic analysis of ocular adnexal lymphomas: extranodal marginal zone b-cell lymphoma constitutes the vast majority of ocular lymphomas among Koreans and affects younger patients. (12749009)
2003
34
Genetic abnormalities in marginal zone B-cell lymphoma. (12551819)
2003
35
Burkitt lymphoma following splenic marginal zone lymphoma. evidence for two independent B-cell clones. (12581905)
2003
36
Complete remission of chronic plaque psoriasis and gastric marginal zone B-cell lymphoma of MALT type after treatment with 2-chlorodeoxyadenosine. (12454707)
2002
37
Primary marginal zone B-cell lymphoma of the lymph node resembling plasmacytoma arising from a plasma cell variant of Castleman's disease. A clinicopathological and immunohistochemical study of seven patients. (12645666)
2002
38
Terminal plasmocytoid differentiation of malignant B cells induced by autotumor-reactive CD4(+) T cells in one case of splenic marginal zone B-cell lymphoma. (11783434)
2002
39
Molecular-cytogenetic comparison of mucosa-associated marginal zone B-cell lymphoma and large B-cell lymphoma arising in the gastro-intestinal tract. (11433522)
2001
40
Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type. (11474283)
2001
41
Blastic transformation of splenic marginal zone B-cell lymphoma. (10782161)
2000
42
Eradication of Borrelia burgdorferi infection in primary marginal zone B-cell lymphoma of the skin. (10685647)
2000
43
Retreatment with chimeric CD 20 monoclonal antibody in a patient with nodal marginal zone B-cell lymphoma. (10962535)
2000
44
Primary nodal marginal zone B-cell lymphoma arising from more than one clonal neoplastic population. (11100064)
2000
45
Somatic mutation analysis of IgH variable regions reveals that tumor cells of most parafollicular (monocytoid) B-cell lymphoma, splenic marginal zone B-cell lymphoma, and some hairy cell leukemia are composed of memory B lymphocytes. (10088550)
1999
46
A mucosa-associated lymphoid tissue (MALT) type lymphoma (marginal zone B-cell lymphoma) from the palatine tonsil. (9643507)
1998
47
Frequent involvement of chromosomes 1, 3, 7 and 8 in splenic marginal zone B-cell lymphoma. (9266948)
1997
48
CD5+ extranodal marginal zone B-cell (MALT) lymphoma. A low grade neoplasm with a propensity for bone marrow involvement and relapse. (8561085)
1996
49
Marginal zone B cell lymphoma of the parotid glands: results of a randomised trial comparing radiotherapy to combined therapy. (9039228)
1996
50
Trisomy 3 in marginal zone B-cell lymphoma: a study based on cytogenetic analysis and fluorescence in situ hybridization. (8611468)
1996

Genetic Variations for Marginal Zone B-Cell Lymphoma

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Expression for genes affiliated with Marginal Zone B-Cell Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Marginal Zone B-Cell Lymphoma

Search GEO for disease gene expression data for Marginal Zone B-Cell Lymphoma.

Pathways for genes affiliated with Marginal Zone B-Cell Lymphoma

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 51QIAGEN, 52R&D Systems, 4Cell Signaling Technology, 55SinoBiological
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Pathways related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CD40LG, IRF4
210.0CD79A, AIRE
39.8TNFAIP3, MALT1, BCL10
4
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9.8MALT1, CD40LG, BCL10
59.7BIRC3, CD40LG, TNFAIP3
69.7CCND1, TLR4, PIM1
79.6CD5, CD79A, BCL6, BCL10
89.5BCL3, BIRC3, TNFAIP3
9
Hide members
9.5BCL10, BIRC3, MALT1, TLR4
109.4TLR4, TNFAIP3, IRF4, MALT1, BCL10
11
Hide members
9.4IRF4, MALT1, CD40LG, CD79A, BCL10
129.4CCND1, PIM1, BIRC3, PAX5
13
Hide members
9.3CCND1, TLR4, MALT1, CD79A, BCL10
14
Hide members
9.2BCL10, BCL3, MALT1, TNFAIP3, TLR4
15
Hide members
9.2TLR4, TNFAIP3, MALT1, CD40LG, BIRC3
169.2TNFAIP3, PIM1, MALT1, BIRC3, BCL10
179.0BCL10, BIRC3, CD40LG, MALT1, TNFAIP3, TLR4
189.0PIM1, MALT1, CD79A, PAX5, BCL6, BCL10
19
Hide members
8.6C1S, TLR4, TNFAIP3, IRF4, MALT1, CD40LG

Compounds for genes affiliated with Marginal Zone B-Cell Lymphoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4410.4CD40LG, CD79A
2sandoglobulin4410.3CD40LG, CD79A
3glucuronoxylomannan4410.3CD40LG, TLR4
4paclitaxel44 49 1112.3CCND1, CDKN2A
5doxycycline44 1111.3CD40LG, CD79A
6vancomycin44 1111.2CD79A, CD40LG
7pneumococcal4410.2CD79A, CD40LG, TLR4
8mannan4410.1CD79A, CD40LG, TLR4
9allergens4410.0TLR4, CD40LG, CD79A
10blys4410.0CD79A, CD40LG
11cytidine44 11 2411.9CD40LG, CD79A, PAX5, BCL6
12anti-fungal449.9TLR4, CDKN2A, CD40LG, CD79A
13aspirin44 49 28 2412.9CD79A, CD40LG, TLR4, C1S
14thalidomide44 49 59 1112.8BIRC3, CD40LG, CCND1
15vincristine44 49 1111.8BCL6, CDKN2A, MAD2L1, CCND1
16folate449.8CCND1, CDKN2A, CD40LG, CD79A
17agar449.7CD79A, CD40LG, CDKN2A, CCND1
18rituximab44 49 1111.7C1S, CD40LG, CD79A, PAX5, BCL6
19sb 20358044 5910.7CCND1, TLR4, AIRE, BIRC3
20fibrinogen449.6C1S, TLR4, CD40LG, CD79A
21n acetylcysteine449.6CD79A, CD40LG, CDKN2A, TLR4, CCND1
22cytosine44 2410.5PAX5, CDKN2A, AIRE
23polysaccharide449.5TLR4, CD40LG, CD79A, SPN
24serine449.4CCND1, TLR4, PIM1, MAD2L1, BIRC3, BCL10
25doxorubicin44 49 1111.4BCL6, BIRC3, CD40LG, CDKN2A, CCND1
26cisplatin44 49 59 1112.4CCND1, TLR4, MAD2L1, CDKN2A, CD40LG, BIRC3
27rapamycin449.3BCL3, CD40LG, PIM1, CCND1
28h2o2449.2SPN, CD79A, CDKN2A, TNFAIP3, TLR4
29testosterone44 59 11 2412.2CCND1, CDKN2A, CD40LG, CD79A, PAX5
30alanine449.1TLR4, PIM1, CDKN2A, CD40LG, CD79A, BIRC3
31retinoic acid44 249.9BCL6, SPN, CD79A, CD40LG, CDKN2A, TLR4
32paraffin448.5BCL6, CCND1, MALT1, CD5, CDKN2A, CD40LG
33tyrosine447.9CCND1, TLR4, PIM1, RHOH, AIRE, CD5

GO Terms for genes affiliated with Marginal Zone B-Cell Lymphoma

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16Gene Ontology
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Cellular components related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor complexGO:04669610.2TLR4, BCL10
2CBM complexGO:03244910.2BCL10, MALT1
3protein complexGO:0432349.5BCL10, BCL3, CDKN2A, MALT1
4external side of plasma membraneGO:0098979.4SPN, CD79A, CD40LG, CD5, TLR4
5perinuclear region of cytoplasmGO:0484719.3TLR4, MALT1, MAD2L1, BCL3, BCL10
6cytosolGO:0058298.4CCND1, TNFAIP3, IRF4, RHOH, MALT1, MAD2L1
7plasma membraneGO:0058868.1PIM1, RHOH, AIRE, MALT1, CD5, CD40LG
8cytoplasmGO:0057377.5TLR4, TNFAIP3, IRF4, PIM1, RHOH, AIRE
9nucleusGO:0056347.4AIRE, PIM1, IRF4, TNFAIP3, CCND1, MALT1

Biological processes related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell receptor signaling pathwayGO:05085610.4BCL10, MALT1
2positive regulation of interleukin-8 biosynthetic processGO:04541610.3BCL10, TLR4
3positive regulation of interleukin-10 biosynthetic processGO:04508210.3BCL3, IRF4
4response to fungusGO:00962010.3BCL10, MALT1
5regulation of germinal center formationGO:00263410.3BCL6, TNFAIP3
6response to molecule of bacterial originGO:00223710.2BCL10, MALT1, TNFAIP3
7protein oligomerizationGO:05125910.1BCL10, MALT1, TNFAIP3
8B cell proliferationGO:04210010.1CD79A, CD40LG
9negative regulation of cell-matrix adhesionGO:00195310.1BCL6, CDKN2A
10negative regulation of phosphorylationGO:04232610.1RHOH, CDKN2A, BIRC3
11germinal center formationGO:00246710.0BCL3, BCL6
12I-kappaB kinase/NF-kappaB cascadeGO:00724910.0BCL10, BCL3, TLR4
13positive regulation of tumor necrosis factor biosynthetic processGO:04253510.0TLR4, SPN
14B cell differentiationGO:03018310.0CD40LG, CD79A, BCL6
15T-helper 1 type immune responseGO:0420889.9BCL3, TLR4
16positive regulation of T cell activationGO:0508709.9BCL10, MALT1
17positive regulation of NF-kappaB transcription factor activityGO:0510929.8BCL10, MALT1, TLR4
18positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.8TLR4, MALT1, BIRC3, BCL10
19positive regulation of transcription, DNA-dependentGO:0458939.6IRF4, AIRE, CDKN2A, BCL3, BCL10
20defense response to bacteriumGO:0427429.5TLR4, SPN, BCL3
21toll-like receptor signaling pathwayGO:0022249.5BCL10, BIRC3, TLR4
22innate immune responseGO:0450879.4C1S, TLR4, TNFAIP3, MALT1, BIRC3, BCL10
23positive regulation of transcription from RNA polymerase II promoterGO:0459449.4BCL3, PAX5, CDKN2A, AIRE, IRF4, TLR4
24negative regulation of apoptotic processGO:0430668.9BCL3, TNFAIP3, PIM1, MALT1, MAD2L1, CD40LG

Molecular functions related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activator activityGO:01920910.0BCL10, MALT1
2protein self-associationGO:0436219.7TNFAIP3, MALT1, BCL10
3protease bindingGO:0020209.5BCL10, MALT1, TNFAIP3
4transmembrane signaling receptor activityGO:0048889.4SPN, CD79A, CD5, TLR4
5transcription factor bindingGO:0081349.3IRF4, PIM1, CDKN2A, BCL3, BCL10
6protein bindingGO:0055156.8BCL10, C1S, CCND1, TLR4, TNFAIP3, IRF4

Products for genes affiliated with Marginal Zone B-Cell Lymphoma

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3CDC
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27ICD9CM
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40NDF-RT
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