MCID: MRG003
MIFTS: 57

Marginal Zone B-Cell Lymphoma malady

Cancer diseases, Immune diseases categories

Summaries for Marginal Zone B-Cell Lymphoma

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A b-cell lymphocytic neoplasm presenting primarily in the marginal zone.

MalaCards: Marginal Zone B-Cell Lymphoma is related to b-cell lymphomas and malt lymphoma. An important gene associated with Marginal Zone B-Cell Lymphoma is MALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1), and among its related pathways are Creation of C4 and C2 activators and TP53 network. The compounds glucuronoxylomannan and 2-methoxyestradiol have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and lung, and related mouse phenotypes are pigmentation and digestive/alimentary.

Aliases & Classifications for Marginal Zone B-Cell Lymphoma

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9Disease Ontology, 32LifeMap Discoveryā„¢, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

marginal zone b-cell lymphoma 9 32 63


External Ids:

Disease Ontology9 DOID:0050748

Related Diseases for Marginal Zone B-Cell Lymphoma

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18GeneCards, 19GeneDecks
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Diseases related to Marginal Zone B-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas32.0CD5, PIM1, RB1, BIRC3, BCL10, BCL6
2malt lymphoma31.3CCND1, IRF4, TLR4, MALT1, BCL6, CD5
3macroglobulinemia31.2PAX5, CD5
4mantle cell lymphoma31.1CCND1, BCL6
5plasmacytoma31.0PAX5, IRF4, BCL6
6hodgkin's lymphoma30.9PAX5, IRF4, BCL3, BCL6, BIRC3
7hepatitis c30.9TLR4, BCL6, CD40LG
8hairy cell leukemia30.9CD5, BCL6, CCND1
9peripheral t-cell lymphoma30.8PAX5, BCL3, BCL6, CD5
10cryoglobulinemia30.7CD40LG, CD5
11anaplastic large cell lymphoma30.7BCL6, BCL3, PAX5
12b-cell chronic lymphocytic leukemia30.6PAX5, CCND1, BCL10, CD5
13adenocarcinoma30.6SPN, TP53, CCND1, BIRC3, RB1, CDKN2A
14follicular lymphoma30.4CD5, BIRC3, BCL10, BCL6, BCL3, CCND1
15lung adenocarcinoma30.4CDKN2A, RB1, CCND1, TP53
16chronic lymphocytic leukemia30.4PAX5, CCND1, BCL3, BCL6, BCL10, BIRC3
17myeloma30.4PAX5, IRF4, CCND1, BCL6, BIRC3, RB1
18melanoma30.3PIM1, TLR4, TP53, IRF4, CCND1, RB1
19leukemia30.3BCL6, BCL3, CCND1, IRF4, PAX5, TP53
20primary cutaneous marginal zone b-cell lymphoma11.2
21nodal marginal zone b-cell lymphoma11.1
22hepatitis10.9
23amyloidosis10.8
24thyroiditis10.8
25diffuse large b-cell lymphoma10.7
26arthritis10.7
27histiocytosis10.7
28rheumatoid arthritis10.7
29castleman's disease10.6
30hepatitis c virus10.6
31langerhans-cell histiocytosis10.5
32composite lymphoma10.5
33meningioma10.5
34meningitis10.5
35fibrous meningioma10.4
36progressive multifocal leukoencephalopathy10.4
37sialadenitis10.4
38hepatitis b10.4
39tonsillitis10.4
40choroiditis10.4
41schnitzler syndrome10.4
42tracheal stenosis10.4
43primary biliary cirrhosis10.4
44systemic lupus erythematosus10.4
45primary cutaneous amyloidosis10.4
46splenic marginal zone lymphoma10.4
47cervicitis10.4
48chorioretinitis10.4
49keratopathy10.4
50lipoma10.4

Graphical network of the top 20 diseases related to Marginal Zone B-Cell Lymphoma:



Diseases related to marginal zone b-cell lymphoma

Symptoms for Marginal Zone B-Cell Lymphoma

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Drugs & Therapeutics for Marginal Zone B-Cell Lymphoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢
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Approved drugs:

Search CenterWatch for Marginal Zone B-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Marginal Zone B-Cell Lymphoma

Search NIH Clinical Center for Marginal Zone B-Cell Lymphoma

Search CenterWatch for Marginal Zone B-Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Marginal Zone B-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Marginal Zone B-Cell Lymphoma

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Anatomical Context for Marginal Zone B-Cell Lymphoma

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34MalaCards
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MalaCards organs/tissues related to Marginal Zone B-Cell Lymphoma:

34
B cells, Bone, Lung, Thyroid, T cells, Bone marrow, Colon, Salivary gland, Breast, Small intestine, Skin, Thymus, Uterus, Lymph node, Liver, Spleen, Spinal cord, Brain, Tonsil, Appendix

Animal Models for Marginal Zone B-Cell Lymphoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Marginal Zone B-Cell Lymphoma:

38 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.0TLR4, TP53, RB1, CDKN2A
2MP:00053818.6AIRE, TLR4, TP53, CCND1, RB1, CDKN2A
3MP:00053918.6AIRE, TLR4, TP53, CCND1, RB1, CDKN2A
4MP:00053708.5AIRE, TLR4, TP53, BCL6, RB1, CDKN2A
5MP:00107718.4CD40LG, CDKN2A, RB1, CCND1, TP53, TLR4
6MP:00053908.4TLR4, TP53, PAX5, CCND1, RB1, CDKN2A
7MP:00053888.3AIRE, TLR4, TP53, CCND1, BCL6, RB1
8MP:00053798.2AIRE, TP53, CCND1, RB1, CDKN2A, CD40LG
9MP:00030128.2AIRE, PIM1, TP53, BCL6, RB1, CD5
10MP:00053698.0TLR4, TP53, BCL6, BIRC3, RB1, CDKN2A
11MP:00053898.0AIRE, TLR4, TP53, CCND1, BCL6, RB1
12MP:00036318.0AIRE, TLR4, TP53, PAX5, CCND1, BCL10
13MP:00020067.8AIRE, SPN, TLR4, TP53, IRF4, CCND1
14MP:00053857.6TLR4, TP53, CCND1, BCL6, BIRC3, RB1
15MP:00053787.5AIRE, PIM1, TLR4, TP53, PAX5, CCND1
16MP:00028737.4AIRE, PIM1, TP53, PAX5, CCND1, BCL6
17MP:00053766.9AIRE, TLR4, TP53, CCND1, BCL3, BCL6
18MP:00107686.5CCND1, PAX5, TP53, TLR4, AIRE, BCL3
19MP:00053846.3AIRE, PIM1, TLR4, TP53, PAX5, CCND1
20MP:00053974.3AIRE, CDKN2A, CD5, RB1, RHOH, BIRC3
21MP:00053874.3AIRE, CD40LG, CDKN2A, CD5, RB1, RHOH

Publications for Marginal Zone B-Cell Lymphoma

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53PubMed
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Articles related to Marginal Zone B-Cell Lymphoma:

(show top 50)    (show all 349)
idTitleAuthorsYear
1
Nodal marginal zone B-cell lymphoma showing prominent plasma cell differentiation in the pleural effusion: A case report. (22833332)
2014
2
Rituximab plus bendamustine is active in pretreated patients with extragastric marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma). (23925930)
2014
3
Two Cases of Diffuse Large B-Cell Lymphomas in the Cervical Lymph Nodes in Patients with Low-Grade Gastric Marginal Zone B-Cell Lymphoma (MALT Lymphoma). (23767042)
2013
4
Is bone marrow biopsy always indicated in patients with primary cutaneous marginal zone B-cell lymphoma? (23954046)
2013
5
Subcutaneous dissemination pattern in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue lymphoma. (22180423)
2012
6
Letter: Primary cutaneous marginal zone B cell lymphoma of the face: a challenging diagnosis. (22398233)
2012
7
Nodal marginal zone B-cell lymphoma: a diagnostic and therapeutic dilemma. (22393802)
2012
8
A case of monoclonal gammopathy in extranodal marginal zone B-cell lymphoma of the small intestine. (21239866)
2011
9
Central nervous system marginal zone B-cell lymphoma associated with Chlamydophila psittaci infection. (21239044)
2011
10
Cutaneous manifestations of B-cell chronic lymphocytic leukemia associated with Borrelia burgdorferi infection showing a marginal zone B-cell lymphoma-like infiltrate. (21946761)
2011
11
An Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast - Its Diagnosis and the Role of Radiotherapy in its Management. (22619650)
2011
12
Pulmonary marginal zone B-cell lymphoma of MALT type--what is a prognostic factor and which is the optimal treatment, operation, or chemotherapy?: Consortium for Improving Survival of Lymphoma (CISL) study. (20024551)
2010
13
CD123-positive plasmacytoid dendritic cells in primary cutaneous marginal zone B-cell lymphoma: A crucial role and a new lymphoma paradigm. (19940749)
2010
14
Primary cutaneous marginal zone B-cell lymphoma with amyloid deposition: report of two cases with review of literature. (20507739)
2010
15
Low grade marginal zone B-cell lymphoma presenting as local amyloidosis in a submandibular salivary gland. (20970706)
2010
16
Pediatric primary cutaneous marginal zone B-cell lymphoma treated with intralesional rituximab. (20542839)
2010
17
A minute focus of extranodal marginal zone B-cell lymphoma arising in Hashimoto thyroiditis diagnosed with PCR after laser capture microdissection: a case report. (19735541)
2009
18
Relapsed or refractory nongastric marginal zone B-cell lymphoma: multicenter retrospective analysis of 92 cases. (19890833)
2009
19
Primary cutaneous marginal zone B-cell lymphomas are targeted by aberrant somatic hypermutation. (18704108)
2009
20
Absence of efficacy of thalidomide monotherapy in patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma). (19654203)
2009
21
Marginal zone B-cell lymphoma of bronchus-associated lymphoid tissue: imaging findings in 21 patients. (18071012)
2008
22
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue arising in the extracranial head and neck region: a high rate of dissemination and disease recurrence. (18234544)
2008
23
Thymic epithelial cells expressed unusual follicular dendritic cell markers: thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. (18477221)
2008
24
The majority of cutaneous marginal zone B-cell lymphomas expresses class-switched immunoglobulins and develops in a T-helper type 2 inflammatory environment. (18687986)
2008
25
Concurrence of marginal zone B-cell lymphoma MALT-type and Langerhans cell histiocytosis in a thyroid gland with Hashimoto disease. (18401582)
2008
26
Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma. (17947227)
2008
27
Primary cutaneous marginal zone B-cell lymphoma may exhibit both the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18)(q32;q21) IGH/MALT1 translocation: an indicator for clonal transformation towards higher-grade B-cell lymphoma? (17519619)
2007
28
Primary marginal zone B-cell lymphoma of gastrointestinal tract presenting as multiple lymphomatoid polyposis. (16586077)
2007
29
Genome-wide array-based comparative genomic hybridization of ocular marginal zone B cell lymphoma: comparison with pulmonary and nodal marginal zone B cell lymphoma. (17492759)
2007
30
Schnitzler syndrome associated with systemic marginal zone B-cell lymphoma. (16965436)
2006
31
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue arising in the lateral ventricle. (16194887)
2005
32
Cutaneous lymphoid hyperplasia and marginal zone B-cell lymphoma following vaccination. (16112365)
2005
33
Primary extranodal marginal zone B-cell lymphoma of MALT type of the endometrium. (15047243)
2004
34
Primary cutaneous immunocytoma/marginal zone B-cell lymphoma: a case with unusual course. (15024193)
2004
35
Hen's teeth?: Extranodal marginal zone B cell lymphoma of MALT type in nasal mucosa. (15574163)
2004
36
Nodal marginal zone B-cell lymphoma with a novel t(X;5)(q28;q22): conventional and molecular cytogenetic analysis. (12781450)
2003
37
Extranodal marginal zone B-cell lymphoma of MALT-type of the lung: single-center experience with 12 patients. (12802920)
2003
38
Rituximab for treatment of advanced extranodal marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue lymphoma. (14707449)
2003
39
API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. (12651604)
2003
40
Genomic abnormalities acquired in the blastic transformation of splenic marginal zone B-cell lymphoma. (12688315)
2003
41
Extranodal marginal zone B-cell lymphoma of the lacrimal gland associated with crystal-storing histiocytosis. (11772588)
2002
42
Complete remission of chronic plaque psoriasis and gastric marginal zone B-cell lymphoma of MALT type after treatment with 2-chlorodeoxyadenosine. (12454707)
2002
43
Somatic hypermutation of immunoglobulin heavy chain variable region genes in thymic marginal zone B-cell lymphoma of MALT type of a patient with SjAPgren's syndrome. (11895498)
2002
44
Hodgkin-like transformation of a marginal zone B-cell lymphoma of the larynx. (11842381)
2002
45
Extranodal marginal zone B cell lymphoma of MALT type involving the mucosa of both the urinary bladder and stomach. (12101213)
2002
46
Marginal-zone B-cell lymphoma, extranodal-malt-type: report of three cases. (11766741)
2001
47
Gastric marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type: management of the disease. (10975767)
2000
48
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) of the sigmoid colon. (11115928)
2000
49
Somatic mutation analysis of IgH variable regions reveals that tumor cells of most parafollicular (monocytoid) B-cell lymphoma, splenic marginal zone B-cell lymphoma, and some hairy cell leukemia are composed of memory B lymphocytes. (10088550)
1999
50
B-cell lymphoma accompanying monoclonal macroglobulinemia with features suggesting marginal zone B-cell lymphoma. (9195780)
1997

Variations for Marginal Zone B-Cell Lymphoma

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Expression for genes affiliated with Marginal Zone B-Cell Lymphoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Marginal Zone B-Cell Lymphoma

Search GEO for disease gene expression data for Marginal Zone B-Cell Lymphoma.

Pathways for genes affiliated with Marginal Zone B-Cell Lymphoma

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 5Cell Signaling Technology, 54QIAGEN, 58SinoBiological, 61Thomson Reuters, 55R&D Systems
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Pathways related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8BCL10, MALT1, C1S
2
Show member pathways
9.7CDKN2A, TP53
39.6PAX5, RB1, CD40LG
4
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.6IRF4, MALT1, BCL10, CD40LG
59.5CD40LG, BCL6, IRF4
69.5TLR4, IRF4, MALT1, BCL10
79.4TLR4, TP53, CCND1
8
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.4TP53, CCND1, RB1
9
Show member pathways
9.4TP53, CCND1, RB1
109.4RB1, CCND1, TP53
119.4RB1, CCND1, TP53
129.4RB1, CCND1, TP53
139.4TP53, RB1, CDKN2A
149.4CDKN2A, RB1, TP53
159.4CDKN2A, RB1, TP53
169.3PIM1, TLR4, CCND1
17
Show member pathways
Signal transduction PTEN pathway61
9.2CCND1, TP53, PIM1
189.2TP53, BCL6, RB1
19
Show member pathways
9.2BCL10, BCL3, MALT1, TLR4
209.2BCL6, BCL10, RB1, CD5
21
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.1BIRC3, BCL10, MALT1, TLR4
22
Show member pathways
9.1BIRC3, TP53, TLR4
23
Show member pathways
9.1TP53, BIRC3, RB1
249.1TP53, CCND1, RB1, CDKN2A
25
Show member pathways
9.1TP53, CCND1, RB1, CDKN2A
26
Show member pathways
9.1TP53, CCND1, RB1, CDKN2A
27
Show member pathways
DNA damage response39
9.1TP53, CCND1, RB1, CDKN2A
28
Show member pathways
Cell cycle39
9.1CDKN2A, RB1, CCND1, TP53
299.1TP53, CCND1, RB1, CDKN2A
30
Show member pathways
9.1TP53, CCND1, RB1, CDKN2A
31
Show member pathways
Signaling Pathways in Glioblastoma39
9.1TP53, CCND1, RB1, CDKN2A
32
Show member pathways
9.1CDKN2A, RB1, CCND1, TP53
339.1CDKN2A, RB1, CCND1, TP53
349.0TLR4, TP53, CCND1, RB1
35
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.0TLR4, TP53, CCND1, RB1
36
Show member pathways
9.0TLR4, TP53, CCND1, MALT1, BCL10
37
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
9.0TP53, CCND1, MALT1, BCL10, RB1
38
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.0TP53, CCND1, BCL6, CDKN2A
398.9BIRC3, BCL10, MALT1, PIM1
40
Show member pathways
8.9AIRE, MALT1, BCL10, BIRC3, CD40LG
418.9PIM1, TP53, CCND1, CDKN2A
42
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
8.9CDKN2A, BIRC3, IRF4, TP53
438.9PIM1, PAX5, MALT1, BCL6, BCL10
44
Show member pathways
8.9CDKN2A, RB1, BCL10, CCND1, TP53
458.8CD40LG, BIRC3, BCL10, MALT1, TLR4
468.8BIRC3, CCND1, PAX5, PIM1
478.8TP53, CCND1, BIRC3, RB1
488.8TP53, PAX5, BCL6, BIRC3
49
Show member pathways
8.6TLR4, TP53, MALT1, BIRC3, CD40LG
508.4TP53, CCND1, BIRC3, RB1, CDKN2A

Compounds for genes affiliated with Marginal Zone B-Cell Lymphoma

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46Novoseek, 62Tocris Bioscience, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 3BitterDB
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Compounds related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1glucuronoxylomannan4610.0TLR4, CD40LG
22-methoxyestradiol46 62 2511.8TP53, PAX5, CCND1
3anti-fungal469.8CD40LG, CDKN2A, TLR4
4cytidine46 25 1211.8PAX5, BCL6, CD40LG
5hpvs469.8TP53, RB1, CDKN2A
6acnu469.7CDKN2A, TP53
7aflatoxin b146 2510.7TP53, RB1, CDKN2A
8hmba469.7TP53, RB1, CDKN2A
9[alcl]469.7RB1, BCL3, PAX5
10cytosine46 2510.7AIRE, PAX5, RB1, CDKN2A
11n-(4-hydroxyphenyl)retinamide469.7TP53, CCND1, RB1
12rituximab46 52 1211.6CD40LG, BCL6, PAX5, C1S
13olomoucine46 1210.5TP53, CCND1, RB1, CDKN2A
14crcs469.5CDKN2A, RB1, CCND1, TP53
15depsipeptide469.5TP53, CCND1, RB1, CDKN2A
16roscovitine469.5CDKN2A, RB1, CCND1, TP53
17flavopiridol46 1210.5TP53, CCND1, RB1, CDKN2A
18thymidylate469.5CDKN2A, RB1, CCND1, TP53
19methotrexate52 46 1211.4CDKN2A, RB1, CCND1, TLR4
20egcg469.4CDKN2A, RB1, CCND1, TP53
21bortezomib46 52 1211.4TP53, CCND1, CD40LG
22fludarabine46 52 1211.4TP53, BIRC3, CD40LG
23agar469.4CD40LG, CDKN2A, RB1, CCND1
24n acetylcysteine469.2TLR4, TP53, CCND1, CDKN2A, CD40LG
25genistein46 30 62 3 25 1214.2TLR4, CCND1, RB1, CDKN2A, CD40LG
26mg 13246 6210.2TP53, CCND1, BIRC3, CDKN2A
27butyrate469.1TP53, CCND1, RB1, CDKN2A
28vincristine46 52 1211.0TP53, CCND1, BCL6, RB1, CDKN2A
295fluorouracil469.0TP53, BIRC3, RB1, CDKN2A
30testosterone46 62 25 1212.0CD40LG, CDKN2A, RB1, CCND1, PAX5
31adriamycin468.9TP53, CCND1, BIRC3, RB1, CDKN2A
32rapamycin468.9PIM1, CCND1, BCL3, RB1, CD40LG
33pdtc468.8BIRC3, TP53, TLR4
34ly294002468.8TLR4, TP53, CCND1, BIRC3, RB1
35vegf468.8TLR4, TP53, CCND1, RB1, CDKN2A, CD40LG
36sb 20358046 629.6AIRE, TLR4, TP53, CCND1, BIRC3, RB1
37oligonucleotide468.6TP53, PAX5, CCND1, BIRC3, RB1, CDKN2A
38actinomycin d468.5TLR4, TP53, BIRC3, RB1, CDKN2A, CD40LG
39estrogen468.5TP53, CCND1, BCL6, RB1, CDKN2A, CD40LG
40paclitaxel46 52 1210.5TLR4, TP53, CCND1, BIRC3, RB1, CDKN2A
41alanine468.5PIM1, TLR4, BCL10, BIRC3, CDKN2A, CD40LG
42cycloheximide468.4CDKN2A, BIRC3, BCL6, CCND1, TP53, TLR4
43h2o2468.3CDKN2A, RB1, TP53, TLR4, SPN
44cisplatin46 52 62 1211.3TLR4, TP53, CCND1, BIRC3, RB1, CDKN2A
45doxorubicin46 52 1210.2TP53, CCND1, BCL6, BIRC3, RB1, CDKN2A
46retinoic acid46 258.6SPN, TLR4, TP53, CCND1, BCL6, RB1
47paraffin467.3SPN, TP53, PAX5, CCND1, MALT1, BCL6
48calcium46 52 25 1210.1SPN, PIM1, C1S, TLR4, PAX5, BIRC3
49tyrosine466.0PAX5, TLR4, PIM1, SPN, AIRE, CCND1
50serine465.5CD40LG, AIRE, SPN, PIM1, C1S, TLR4

GO Terms for genes affiliated with Marginal Zone B-Cell Lymphoma

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17Gene Ontology
See all sources

Cellular components related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CBM complexGO:03244910.2BCL10, MALT1
2immunological synapseGO:00177210.1RHOH, BCL10
3lipopolysaccharide receptor complexGO:04669610.0BCL10, TLR4
4replication forkGO:0056579.3BCL6, TP53
5external side of plasma membraneGO:0098978.9SPN, TLR4, CD5, CD40LG
6protein complexGO:0432348.4CDKN2A, BIRC3, BCL10, BCL3, MALT1, TP53
7cytosolGO:0058297.9TP53, IRF4, CCND1, MALT1, BCL10, BIRC3
8cytoplasmGO:0057376.9AIRE, PIM1, TLR4, TP53, MALT1, BCL3
9nucleusGO:0056346.0IRF4, PAX5, TP53, PIM1, AIRE, CCND1

Biological processes related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell receptor signaling pathwayGO:05085610.5BCL10, MALT1
2response to fungusGO:00962010.5MALT1, BCL10
3response to molecule of bacterial originGO:00223710.4MALT1, BCL10
4positive regulation of interleukin-8 biosynthetic processGO:04541610.3TLR4, BCL10
5positive regulation of T cell activationGO:05087010.3BCL10, MALT1
6positive regulation of interleukin-10 biosynthetic processGO:04508210.1BCL3, IRF4
7mitotic G1 DNA damage checkpointGO:03157110.1CCND1, TP53
8cell cycle checkpointGO:00007510.1CDKN2A, RB1
9replicative senescenceGO:09039910.0TP53, CDKN2A
10negative regulation of cell-matrix adhesionGO:0019539.9BCL6, CDKN2A
11T-helper 1 type immune responseGO:0420889.9BCL3, TLR4
12positive regulation of NF-kappaB transcription factor activityGO:0510929.9TLR4, MALT1, BCL10
13defense response to protozoanGO:0428329.9BCL3, IRF4
14germinal center formationGO:0024679.9BCL3, BCL6
15positive regulation of interleukin-12 productionGO:0327359.8CD40LG, TLR4
16positive regulation of protein ubiquitinationGO:0313989.8BIRC3, BCL10, MALT1
17DNA damage response, signal transduction by p53 class mediatorGO:0303309.8TP53, BCL3
18negative regulation of reactive oxygen species metabolic processGO:20003789.8BIRC3, TP53
19positive regulation of cell cycle arrestGO:0711589.7TP53, CDKN2A
20Ras protein signal transductionGO:0072659.7CDKN2A, RB1, TP53
21negative regulation of phosphorylationGO:0423269.7CDKN2A, RHOH, BIRC3
22response to X-rayGO:0101659.7CCND1, TP53
23positive regulation of tumor necrosis factor biosynthetic processGO:0425359.6TLR4, SPN
24toll-like receptor signaling pathwayGO:0022249.5TLR4, BCL10, BIRC3
25positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.5BIRC3, BCL10, MALT1, TLR4
26protein import into nucleus, translocationGO:0000609.5TP53, BCL3, BCL6
27negative regulation of cell growthGO:0303089.5CDKN2A, BCL6, TP53
28cell cycle arrestGO:0070509.4CDKN2A, RB1, TP53
29innate immune responseGO:0450879.2BIRC3, BCL10, MALT1, TLR4, C1S
30G1/S transition of mitotic cell cycleGO:0000829.2CDKN2A, RB1, CCND1
31cellular response to DNA damage stimulusGO:0069749.2TP53, CCND1, BCL3, BCL6
32regulation of apoptotic processGO:0429819.1TP53, MALT1, BCL3, BIRC3
33defense response to bacteriumGO:0427429.1SPN, TLR4, BCL3
34negative regulation of transcription, DNA-templatedGO:0458928.8TP53, BCL3, BCL6, RB1, CDKN2A
35positive regulation of transcription, DNA-templatedGO:0458938.6AIRE, TP53, IRF4, BCL3, BCL10, RB1
36transcription, DNA-templatedGO:0063518.4AIRE, IRF4, CCND1, BCL3, BCL6, RB1
37negative regulation of apoptotic processGO:0430668.3PIM1, TP53, MALT1, BCL3, BIRC3, CD40LG
38positive regulation of transcription from RNA polymerase II promoterGO:0459448.2CDKN2A, AIRE, TLR4, TP53, PAX5, IRF4

Molecular functions related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1kinase activator activityGO:01920910.2BCL10, MALT1
2NF-kappaB bindingGO:05105910.0CDKN2A, BCL10
3MDM2/MDM4 family protein bindingGO:0973719.9CDKN2A, TP53
4protease bindingGO:0020209.8TP53, MALT1, BCL10
5ubiquitin protein ligase bindingGO:0316259.4RB1, BCL10, TP53
6protein kinase bindingGO:0199019.3CDKN2A, BCL10, CCND1, TP53
7transmembrane signaling receptor activityGO:0048889.1SPN, TLR4, CD5
8identical protein bindingGO:0428028.9AIRE, C1S, TP53, RB1
9sequence-specific DNA binding transcription factor activityGO:0037008.4TP53, PAX5, IRF4, BCL3, BCL6, RB1
10transcription factor bindingGO:0081347.9CDKN2A, PIM1, TP53, IRF4, CCND1, BCL3
11protein bindingGO:0055154.4IRF4, TP53, TLR4, C1S, PIM1, SPN

Products for genes affiliated with Marginal Zone B-Cell Lymphoma

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Sources for Marginal Zone B-Cell Lymphoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
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