MCID: MRG003
MIFTS: 53

Marginal Zone B-Cell Lymphoma malady

Immune diseases category

Summaries for Marginal Zone B-Cell Lymphoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A b-cell lymphocytic neoplasm presenting primarily in the marginal zone.

MalaCards: Marginal Zone B-Cell Lymphoma is related to gastric lymphoma and hepatitis. An important gene associated with Marginal Zone B-Cell Lymphoma is BCL10 (B-cell CLL/lymphoma 10), and among its related pathways are IL4-mediated signaling events and Primary immunodeficiency. The compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and lung, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Marginal Zone B-Cell Lymphoma

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8Disease Ontology, 30LifeMap Discovery™, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

marginal zone b-cell lymphoma 8 30 60


External Ids:

Disease Ontology8 DOID:0050748

Related Diseases for Marginal Zone B-Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Marginal Zone B-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1gastric lymphoma31.5BCL10, BCL6, MALT1
2hepatitis31.2AIRE, CD40LG
3hepatitis b31.2TLR4, CD79A
4amyloidosis31.1CD79A
5thyroiditis31.1CD79A
6central nervous system lymphoma31.0BCL6
7mantle cell lymphoma31.0BCL6, CCND1
8hodgkin's lymphoma31.0IRF4, BIRC3, PAX5, BCL6, BCL3
9arthritis30.9TLR4
10macroglobulinemia30.9CD5, CD79A, PAX5
11rheumatoid arthritis30.9C1S, TLR4, TNFAIP3, CD5, CD40LG, CD79A
12plasmacytoma30.8IRF4, CD79A, PAX5, BCL6
13hepatitis c30.8TLR4, CD40LG, BCL6
14leukemia30.8BCL10, CCND1, TLR4, IRF4, PIM1, CD5
15hairy cell leukemia30.7CCND1, CD5, BCL6
16adenocarcinoma30.7CCND1, MAD2L1, CDKN2A, BIRC3, SPN
17malt lymphoma30.7CCND1, TLR4, IRF4, MALT1, CD5, BIRC3
18tonsillitis30.5CD79A
19anaplastic large cell lymphoma30.5BCL3, BCL6, PAX5
20cryoglobulinemia30.5CD5, CD40LG, CD79A
21lupus erythematosus30.5CD79A, CD40LG, C1S
22primary biliary cirrhosis30.5CD79A, CD40LG, AIRE
23systemic lupus erythematosus30.4C1S, TLR4, CD40LG, CD79A
24melanoma30.4CCND1, TLR4, IRF4, PIM1, CDKN2A
25myeloma30.4BIRC3, PAX5, BCL6, CD79A, CD40LG, IRF4
26chronic lymphocytic leukemia30.4CCND1, CD5, CD40LG, BIRC3, PAX5, BCL6
27splenic marginal zone lymphoma11.0
28lung lymphoma10.8
29thyroid lymphoma10.7
30bone lymphoma10.7
31colon lymphoma10.7
32diffuse large b-cell lymphoma10.7
33hepatitis a10.7
34gastrointestinal lymphoma10.6
35orbit lymphoma10.6
36composite lymphoma10.6
37breast lymphoma10.6
38small intestine lymphoma10.6
39cutaneous t cell lymphoma10.6
40histiocytosis10.6
41thymus lymphoma10.6
42pediatric lymphoma10.6
43primary cutaneous marginal zone b-cell lymphoma10.6
44liver lymphoma10.5
45adult lymphoma10.5
46b cell deficiency10.5
47cell type cancer10.5
48intestinal disease10.5
49langerhans-cell histiocytosis10.5
50meningioma10.5

Graphical network of the top 20 diseases related to Marginal Zone B-Cell Lymphoma:



Diseases related to marginal zone b-cell lymphoma

Clinical Features for Marginal Zone B-Cell Lymphoma

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Drugs & Therapeutics for Marginal Zone B-Cell Lymphoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Marginal Zone B-Cell Lymphoma

Drug clinical trials:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Marginal Zone B-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Marginal Zone B-Cell Lymphoma

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Anatomical Context for Marginal Zone B-Cell Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Marginal Zone B-Cell Lymphoma:

32
B cells, Bone, Lung, T cells, Bone marrow, Thyroid, Colon, Salivary gland, Small intestine, Breast, Skin, Thymus, Uterus, Lymph node, Brain, Liver, Spleen, Spinal cord, Tonsil, Appendix

Animal Models for Marginal Zone B-Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Marginal Zone B-Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.2CCND1, AIRE, MAD2L1, CDKN2A, SPN
2MP:00030128.5TNFAIP3, PIM1, AIRE, CD5, CDKN2A, CD79A
3MP:00053767.8TLR4, TNFAIP3, AIRE, CDKN2A, CD40LG, CD79A
4MP:00107687.5CCND1, TLR4, TNFAIP3, AIRE, MAD2L1, CDKN2A
5MP:00053975.9CCND1, SPN, BCL6, BCL3, BCL10, PAX5
6MP:00053875.9CCND1, TLR4, TNFAIP3, IRF4, PIM1, RHOH
7MP:00053845.9MALT1, MAD2L1, CD5, CDKN2A, CD40LG, CD79A

Publications for Marginal Zone B-Cell Lymphoma

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50PubMed
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Articles related to Marginal Zone B-Cell Lymphoma:

(show top 50)    (show all 381)
idTitleAuthorsYear
1
Is there a role for capsule endoscopy in the staging work-up of patients with gastric marginal zone B-cell lymphoma of MALT? (23955137)
2013
2
Pulmonary marginal zone B-cell lymphoma of MALT type: A Cytological Report With Emphasis on the Usefulness of Detection of Lymphoepithelial Lesion. (24167069)
2013
3
Subcutaneous dissemination pattern in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue lymphoma. (22180423)
2012
4
Uveal extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type with concomitant extraocular lesions in a Japanese man. (21717179)
2011
5
CD123-positive plasmacytoid dendritic cells in primary cutaneous marginal zone B-cell lymphoma: A crucial role and a new lymphoma paradigm. (19940749)
2010
6
Correlation of autoantibodies and CD5+ B cells in ocular adnexal marginal zone B cell lymphomas. (20026703)
2010
7
Marginal zone B-cell lymphoma of the head and neck: a rare case and review. (21225763)
2010
8
Non-gastric marginal zone B-cell lymphoma in Korea: clinical features, treatment, and prognostic factors. (20830217)
2010
9
Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma. (20511668)
2010
10
A minute focus of extranodal marginal zone B-cell lymphoma arising in Hashimoto thyroiditis diagnosed with PCR after laser capture microdissection: a case report. (19735541)
2009
11
Relapsed or refractory nongastric marginal zone B-cell lymphoma: multicenter retrospective analysis of 92 cases. (19890833)
2009
12
High-resolution genome-wide array comparative genomic hybridization in splenic marginal zone B-cell lymphoma. (19647853)
2009
13
Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma. (19696203)
2009
14
The majority of cutaneous marginal zone B-cell lymphomas expresses class-switched immunoglobulins and develops in a T-helper type 2 inflammatory environment. (18687986)
2008
15
Reaction patterns of TRAP and DBA.44 in hairy cell leukemia, hairy cell variant, and nodal and extranodal marginal zone B-cell lymphomas. (18227730)
2008
16
Classical Hodgkin lymphoma concurrently evolving in a patient with marginal zone B-cell lymphoma of the spleen. (18486899)
2008
17
Rituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma. (18306483)
2008
18
Primary central nervous system marginal zone B-cell lymphoma of the Basal Ganglia mimicking low-grade glioma: a case report and review of the literature. (18854286)
2008
19
IgG4-producing marginal zone B-cell lymphoma. (18839275)
2008
20
Primary cutaneous marginal zone B-cell lymphoma in a patient with chronic lymphocytic leukaemia. (17697078)
2007
21
Site-specific morphologic differences in extranodal marginal zone B-cell lymphomas. (17979485)
2007
22
Chromosome instability and translocation t(11;18) in primary gastric marginal zone B-cell lymphoma of MALT-type. (17607663)
2007
23
Cyclin D1 and t(11;14)-positive B-cell neoplasms resembling marginal zone B-cell lymphoma: a morphological variant of mantle cell lymphoma. (17316759)
2007
24
Schnitzler syndrome associated with systemic marginal zone B-cell lymphoma. (16965436)
2006
25
Primary cutaneous marginal zone B-cell lymphoma. (16830956)
2006
26
Topical mechlorethamine and clobetasol in multifocal primary cutaneous marginal zone-B cell lymphoma. (16704661)
2006
27
Primary cutaneous marginal zone B-cell lymphoma (PCMZL-MALT). (16870546)
2006
28
CD20+ nodal marginal zone B-cell lymphoma with CD20-recurrence as an intracranial dural-based mass. (17071504)
2006
29
Florid monocytoid B-cell hyperplasia resembling nodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue type. A histological and immunohistochemical study of four cases. (16989959)
2006
30
Dissemination of a SjAPgren's syndrome-associated extranodal marginal-zone B cell lymphoma: circulating lymphoma cells and invariant mutation pattern of nodal Ig heavy- and light-chain variable-region gene rearrangements. (16385504)
2006
31
Primary cutaneous marginal zone B-cell lymphoma. (16280304)
2005
32
Primary pulmonary plasmacytoma involving bilateral lungs and marked hypergammaglobulinemia: differentiation from extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. (15878199)
2005
33
Stable remission after administration of rituximab in a patient with primary hepatic marginal zone B-cell lymphoma. (15813921)
2005
34
Primary cutaneous immunocytoma/marginal zone B-cell lymphoma: a case with unusual course. (15024193)
2004
35
Long term outcome of patients with gastric marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) following exclusive Helicobacter pylori eradication therapy: experience from a large prospective series. (14684573)
2004
36
Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma. (15507668)
2004
37
Kuttner's tumor of salivary glands resembling marginal zone B-cell lymphoma of the MALT type: a histopathologic and immunohistochemical study of 7 cases. (15494864)
2004
38
Primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue-type in the thymus of a patient with SjAPgren's syndrome and rheumatoid arthritis. (14676452)
2003
39
Radiotherapy for extranodal, marginal zone, B-cell lymphoma of mucosa-associated lymphoid tissue originating in the ocular adnexa: a multiinstitutional, retrospective review of 50 patients. (12910532)
2003
40
Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type. (12842999)
2003
41
Treatment of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type with cladribine: a phase II study. (12228207)
2002
42
Primary cutaneous marginal zone B-cell lymphoma: a clinical, histopathological, immunophenotypic and molecular genetic study of 22 cases. (12452864)
2002
43
Primary extranodal marginal zone B-cell lymphoma of the fallopian tube. (12217767)
2002
44
A novel recurrent translocation t(11;14)(p11;q32) in splenic marginal zone B cell lymphoma. (11480569)
2001
45
Unique phenotypic profile of monocytoid B cells: differences in comparison with the phenotypic profile observed in marginal zone B cells and so-called monocytoid B cell lymphoma. (11290554)
2001
46
Extranodal marginal-zone B-cell lymphoma of the salivary gland. (11510008)
2001
47
Immunoglobulin gene mutations and frequent use of VH1-69 and VH4-34 segments in hepatitis C virus-positive and hepatitis C virus-negative nodal marginal zone B-cell lymphoma. (11438472)
2001
48
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) of the sigmoid colon. (11115928)
2000
49
Marginal zone B-cell lymphomas (MZBL) arising at different sites represent different biological entities. (10862046)
2000
50
A marginal zone pattern may be found in different varieties of non-Hodgkin's lymphoma: the morphology and immunohistology of splenic involvement by B-cell lymphomas simulating splenic marginal zone lymphoma. (9777389)
1998

Genetic Variations for Marginal Zone B-Cell Lymphoma

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Expression for genes affiliated with Marginal Zone B-Cell Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Marginal Zone B-Cell Lymphoma

Search GEO for disease gene expression data for Marginal Zone B-Cell Lymphoma.

Pathways for genes affiliated with Marginal Zone B-Cell Lymphoma

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37NCBI BioSystems Database, 29KEGG, 53Reactome, 51QIAGEN, 52R&D Systems, 4Cell Signaling Technology, 55SinoBiological
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Pathways related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CD40LG, IRF4
210.0CD79A, AIRE
39.8TNFAIP3, MALT1, BCL10
4
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9.8MALT1, CD40LG, BCL10
59.7BIRC3, CD40LG, TNFAIP3
69.7CCND1, TLR4, PIM1
79.6CD5, CD79A, BCL6, BCL10
89.5BCL3, BIRC3, TNFAIP3
9
Hide members
9.5BCL10, BIRC3, MALT1, TLR4
109.4TLR4, TNFAIP3, IRF4, MALT1, BCL10
11
Hide members
9.4IRF4, MALT1, CD40LG, CD79A, BCL10
129.4CCND1, PIM1, BIRC3, PAX5
13
Hide members
9.3CCND1, TLR4, MALT1, CD79A, BCL10
14
Hide members
9.2BCL10, BCL3, MALT1, TNFAIP3, TLR4
15
Hide members
9.2TLR4, TNFAIP3, MALT1, CD40LG, BIRC3
169.2TNFAIP3, PIM1, MALT1, BIRC3, BCL10
179.0BCL10, BIRC3, CD40LG, MALT1, TNFAIP3, TLR4
189.0PIM1, MALT1, CD79A, PAX5, BCL6, BCL10
19
Hide members
8.6C1S, TLR4, TNFAIP3, IRF4, MALT1, CD40LG

Compounds for genes affiliated with Marginal Zone B-Cell Lymphoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4410.4CD40LG, CD79A
2sandoglobulin4410.3CD40LG, CD79A
3glucuronoxylomannan4410.3CD40LG, TLR4
4paclitaxel44 49 1112.3CCND1, CDKN2A
5doxycycline44 1111.3CD40LG, CD79A
6vancomycin44 1111.2CD79A, CD40LG
7pneumococcal4410.2CD79A, CD40LG, TLR4
8mannan4410.1CD79A, CD40LG, TLR4
9allergens4410.0TLR4, CD40LG, CD79A
10blys4410.0CD79A, CD40LG
11cytidine44 11 2411.9CD40LG, CD79A, PAX5, BCL6
12anti-fungal449.9TLR4, CDKN2A, CD40LG, CD79A
13aspirin44 49 28 2412.9CD79A, CD40LG, TLR4, C1S
14thalidomide44 49 59 1112.8BIRC3, CD40LG, CCND1
15vincristine44 49 1111.8BCL6, CDKN2A, MAD2L1, CCND1
16folate449.8CCND1, CDKN2A, CD40LG, CD79A
17agar449.7CD79A, CD40LG, CDKN2A, CCND1
18rituximab44 49 1111.7C1S, CD40LG, CD79A, PAX5, BCL6
19sb 20358044 5910.7CCND1, TLR4, AIRE, BIRC3
20fibrinogen449.6C1S, TLR4, CD40LG, CD79A
21n acetylcysteine449.6CD79A, CD40LG, CDKN2A, TLR4, CCND1
22cytosine44 2410.5PAX5, CDKN2A, AIRE
23polysaccharide449.5TLR4, CD40LG, CD79A, SPN
24serine449.4CCND1, TLR4, PIM1, MAD2L1, BIRC3, BCL10
25doxorubicin44 49 1111.4BCL6, BIRC3, CD40LG, CDKN2A, CCND1
26cisplatin44 49 59 1112.4CCND1, TLR4, MAD2L1, CDKN2A, CD40LG, BIRC3
27rapamycin449.3BCL3, CD40LG, PIM1, CCND1
28h2o2449.2SPN, CD79A, CDKN2A, TNFAIP3, TLR4
29testosterone44 59 11 2412.2CCND1, CDKN2A, CD40LG, CD79A, PAX5
30alanine449.1TLR4, PIM1, CDKN2A, CD40LG, CD79A, BIRC3
31retinoic acid44 249.9BCL6, SPN, CD79A, CD40LG, CDKN2A, TLR4
32paraffin448.5BCL6, CCND1, MALT1, CD5, CDKN2A, CD40LG
33tyrosine447.9CCND1, TLR4, PIM1, RHOH, AIRE, CD5

GO Terms for genes affiliated with Marginal Zone B-Cell Lymphoma

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16Gene Ontology
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Cellular components related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor complexGO:04669610.2TLR4, BCL10
2CBM complexGO:03244910.2BCL10, MALT1
3protein complexGO:0432349.5BCL10, BCL3, CDKN2A, MALT1
4external side of plasma membraneGO:0098979.4SPN, CD79A, CD40LG, CD5, TLR4
5perinuclear region of cytoplasmGO:0484719.3TLR4, MALT1, MAD2L1, BCL3, BCL10
6cytosolGO:0058298.4CCND1, TNFAIP3, IRF4, RHOH, MALT1, MAD2L1
7plasma membraneGO:0058868.1PIM1, RHOH, AIRE, MALT1, CD5, CD40LG
8cytoplasmGO:0057377.5TLR4, TNFAIP3, IRF4, PIM1, RHOH, AIRE
9nucleusGO:0056347.4AIRE, PIM1, IRF4, TNFAIP3, CCND1, MALT1

Biological processes related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell receptor signaling pathwayGO:05085610.4BCL10, MALT1
2positive regulation of interleukin-8 biosynthetic processGO:04541610.3BCL10, TLR4
3positive regulation of interleukin-10 biosynthetic processGO:04508210.3BCL3, IRF4
4response to fungusGO:00962010.3BCL10, MALT1
5regulation of germinal center formationGO:00263410.3BCL6, TNFAIP3
6response to molecule of bacterial originGO:00223710.2BCL10, MALT1, TNFAIP3
7protein oligomerizationGO:05125910.1BCL10, MALT1, TNFAIP3
8B cell proliferationGO:04210010.1CD79A, CD40LG
9negative regulation of cell-matrix adhesionGO:00195310.1BCL6, CDKN2A
10negative regulation of phosphorylationGO:04232610.1RHOH, CDKN2A, BIRC3
11germinal center formationGO:00246710.0BCL3, BCL6
12I-kappaB kinase/NF-kappaB cascadeGO:00724910.0BCL10, BCL3, TLR4
13positive regulation of tumor necrosis factor biosynthetic processGO:04253510.0TLR4, SPN
14B cell differentiationGO:03018310.0CD40LG, CD79A, BCL6
15T-helper 1 type immune responseGO:0420889.9BCL3, TLR4
16positive regulation of T cell activationGO:0508709.9BCL10, MALT1
17positive regulation of NF-kappaB transcription factor activityGO:0510929.8BCL10, MALT1, TLR4
18positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.8TLR4, MALT1, BIRC3, BCL10
19positive regulation of transcription, DNA-dependentGO:0458939.6IRF4, AIRE, CDKN2A, BCL3, BCL10
20defense response to bacteriumGO:0427429.5TLR4, SPN, BCL3
21toll-like receptor signaling pathwayGO:0022249.5BCL10, BIRC3, TLR4
22innate immune responseGO:0450879.4C1S, TLR4, TNFAIP3, MALT1, BIRC3, BCL10
23positive regulation of transcription from RNA polymerase II promoterGO:0459449.4BCL3, PAX5, CDKN2A, AIRE, IRF4, TLR4
24negative regulation of apoptotic processGO:0430668.9BCL3, TNFAIP3, PIM1, MALT1, MAD2L1, CD40LG

Molecular functions related to Marginal Zone B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activator activityGO:01920910.0BCL10, MALT1
2protein self-associationGO:0436219.7TNFAIP3, MALT1, BCL10
3protease bindingGO:0020209.5BCL10, MALT1, TNFAIP3
4transmembrane signaling receptor activityGO:0048889.4SPN, CD79A, CD5, TLR4
5transcription factor bindingGO:0081349.3IRF4, PIM1, CDKN2A, BCL3, BCL10
6protein bindingGO:0055156.8BCL10, C1S, CCND1, TLR4, TNFAIP3, IRF4

Products for genes affiliated with Marginal Zone B-Cell Lymphoma

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Sources for Marginal Zone B-Cell Lymphoma

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3CDC
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25ICD10
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27ICD9CM
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40NDF-RT
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