MCID: MST002
MIFTS: 36

Mast-Cell Leukemia malady

Cancer diseases category
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Summaries for Mast-Cell Leukemia

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Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A leukemia that results in an overwhelming number of tissue mast cells located in peripheral blood.

MalaCards: Mast-Cell Leukemia, also known as leukemia, mast-cell, is related to urticaria and leukemia. An important gene associated with Mast-Cell Leukemia is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and Signaling by FGFR. The compound histamine have been mentioned in the context of this disorder. Affiliated tissues include peripheral blood, myeloid and bone marrow, and related mouse phenotypes are integument and hematopoietic system.

Aliases & Classifications for Mast-Cell Leukemia

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Sources:
8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mast-cell leukemia 8
leukemia, mast-cell 62


External Ids:

Disease Ontology8 DOID:9254
NCIt40 C3169
MeSH35 D007946
ICD1025 C94.3

Related Diseases for Mast-Cell Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mast-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 22)
idRelated DiseaseScoreTop Affiliating Genes
1urticaria30.3FCER1A
2leukemia11.0
3systemic mastocytosis10.7
4mastocytosis10.7
5myeloid leukemia10.4
6aleukemic mast cell leukemia10.4
7acute myeloid leukemia10.4
8aggressive systemic mastocytosis10.3
9cutaneous mastocytosis10.3
10classic mast cell leukemia10.3
11mast-cell sarcoma10.1
12portal hypertension10.1
13sm-ahnmd10.1
14urticaria pigmentosa10.1
15asthma10.1
16histiocytosis10.1
17hypertension10.1
18monocytic leukemia10.1
19sarcoma10.1
20back pain10.1
21hematopoietic stem cell transplantation10.1
22acute basophilic leukemia10.1

Graphical network of the top 20 diseases related to Mast-Cell Leukemia:



Diseases related to mast-cell leukemia

Symptoms for Mast-Cell Leukemia

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Drugs & Therapeutics for Mast-Cell Leukemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Mast-Cell Leukemia

Search NIH Clinical Center for Mast-Cell Leukemia

Genetic Tests for Mast-Cell Leukemia

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Anatomical Context for Mast-Cell Leukemia

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Mast-Cell Leukemia:

33
Myeloid, Bone marrow, Bone, Monocytes

FMA organs/tissues related to Mast-Cell Leukemia:

14
Peripheral blood

Animal Models for Mast-Cell Leukemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Mast-Cell Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6KIT, PSTPIP2, SH3KBP1
2MP:00053977.9KIT, PSTPIP2, FCER1A, SH3KBP1
3MP:00053877.7SH3KBP1, FCER1A, PSTPIP2, KIT

Publications for Mast-Cell Leukemia

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52PubMed
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Articles related to Mast-Cell Leukemia:

(show all 49)
idTitleAuthorsYear
1
Sustained paranoid psychosis in a patient with mast cell leukemia and decreased serotonin level. (23793328)
2013
2
A case of de novo aleukemic mast cell leukemia without c-KIT mutations in exons 8 and 17. (24034180)
2013
3
A case of systemic mastocytosis associated with acute myeloid leukemia terminating as aleukemic mast cell leukemia after allogeneic hematopoietic stem cell transplantation. (23483057)
2013
4
Mast cell leukemia. (23243287)
2013
5
The transcriptome of the human mast cell leukemia cells HMC-1.2: an approach to identify specific changes in the gene expression profile in KitD816V systemic mastocytosis. (23504229)
2013
6
Aleukemic variant of mast cell leukemia. (22482127)
2012
7
Mast-cell leukemia exome sequencing reveals a mutation in the IgE mast-cell receptor I^ chain and KIT V654A. (22173243)
2012
8
Systemic mastocytosis: progressive evolution of an occult disease into fatal mast cell leukemia: unique findings on an unusual hematological neoplasm. (22661384)
2012
9
Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor. (22324351)
2012
10
Death from mast cell leukemia: a young patient with longstanding cutaneous mastocytosis evolving into fatal mast cell leukemia. (22329485)
2012
11
Aberrant expression of CD30 in aggressive systemic mastocytosis and mast cell leukemia: a differential diagnosis to consider in aggressive hematopoietic CD30-positive neoplasms. (21261503)
2011
12
Inhibition of JAK-STAT signaling by TG101348: a novel mechanism for inhibition of KITD816V-dependent growth in mast cell leukemia cells. (20485374)
2010
13
Myelomastocytic leukemia versus mast cell leukemia versus systemic mastocytosis associated with acute myeloid leukemia: a diagnostic challenge. (20658589)
2010
14
The classification of systemic mastocytosis should include mast cell leukemia (MCL) and systemic mastocytosis with a clonal hematologic non-mast cell lineage disease (SM-AHNMD). (20688965)
2010
15
Mast cell leukemia with rapidly progressing portal hypertension. (19883434)
2009
16
Mast cell leukemia: a report of ten cases. (18172645)
2008
17
KIT regulates tyrosine phosphorylation and nuclear localization of beta-catenin in mast cell leukemia. (17949810)
2008
18
Establishment of a murine model of aggressive systemic mastocytosis/mast cell leukemia. (16543062)
2006
19
Cladribine therapy in a patient with an aleukemic subvariant of mast cell leukemia. (15928938)
2005
20
Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. (15972446)
2005
21
Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras. (15735740)
2005
22
Malignant hematopoietic cell lines: in vitro models for the study of mast cell leukemia. (12801523)
2003
23
Mast cell leukemia. (12564414)
2003
24
Induction of apoptosis in the human mast cell leukemia cell line HMC-1 by various antineoplastic drugs. (12688323)
2003
25
Rapid engraftment of mast cells of donor origin in a case of acute myeloid leukemia with mast cell leukemia after allogeneic stem cell transplantation. (12815487)
2003
26
RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. (11956218)
2002
27
Low back pain and myalgias in acute and relapsed mast cell leukemia: a case report. (12048668)
2002
28
Mast cell leukemia--a rare form of myeloid leukemia. (12238304)
2002
29
Synaptotagmin I expression in mast cells of normal human tissues, systemic mast cell disease, and a human mast cell leukemia cell line. (11181737)
2001
30
Connective tissue-type mast cell leukemia in a dog. (10720189)
2000
31
Expression of Bcl-2 by human bone marrow mast cells and its overexpression in mast cell leukemia. (10072109)
1999
32
Sequential immunophenotypic analysis of mast cells in a case of systemic mast cell disease evolving to a mast cell leukemia. (9149916)
1997
33
Expression of multiple chemokine genes by a human mast cell leukemia. (8188667)
1994
34
Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line. (7512180)
1994
35
Identification of mutations in the coding sequence of the proto- oncogene c-kit in a human mast cell leukemia cell line causing ligand- independent activation of c-kit product. (7691885)
1993
36
Porcine mast cell leukemia with systemic mastocytosis. (2492400)
1989
37
Establishment of an immature mast cell line from a patient with mast cell leukemia. (3131594)
1988
38
Mast cell leukemia: report of a case and review of the literature. (3095598)
1986
39
Mast cell leukemia and acute basophilic leukemia. Cytochemical studies. (747630)
1978
40
An approach to immunotherapy using antibody to IgE in mast cell leukemia. (1082794)
1976
41
Chemotherapy in reticulum-cell sarcoma in five dogs and a cat and in mast-cell leukemia in a cat. (4936153)
1971
42
Canine mast cell leukemia. (4376378)
1970
43
Cellular and cell-free transmission of a canine mast cell leukemia. (5674816)
1968
44
Cytology of viable blood cells of tissue mast cell leukemia. (5322365)
1966
45
Relation of mastocytoma to mast cell leukemia, and of heparin, histamine and serotonin to mast cells. (13651348)
1959
46
Tissue mast cell leukemia. (13499582)
1958
47
Mast cell leukemia? Malignant mastocytosis with leukemia-like manifestations. (13471655)
1957
48
Basophilic (myelocyte) or mast cell leukemia in a cat. (13416054)
1957
49
Mast cell leukemia presenting as urticaria pigmentosa; report of a case. (13441358)
1957

Variations for Mast-Cell Leukemia

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Expression for genes affiliated with Mast-Cell Leukemia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mast-Cell Leukemia

Search GEO for disease gene expression data for Mast-Cell Leukemia.

Pathways for genes affiliated with Mast-Cell Leukemia

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 5Cell Signaling Technology
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Pathways related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4KIT, SH3KBP1
2
Show member pathways
9.4KIT, SH3KBP1
3
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)38
9.4KIT, SH3KBP1
49.4SH3KBP1, KIT
59.4KIT, SH3KBP1
69.4KIT, SH3KBP1
7
Show member pathways
9.3KIT, FCER1A

Compounds for genes affiliated with Mast-Cell Leukemia

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45Novoseek, 29IUPHAR, 24HMDB
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Compounds related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1histamine45 29 2411.3KIT, FCER1A

GO Terms for genes affiliated with Mast-Cell Leukemia

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Sources:
16Gene Ontology
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Cellular components related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoskeletonGO:0058569.1PSTPIP2, SH3KBP1
2external side of plasma membraneGO:0098979.0KIT, FCER1A

Biological processes related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor receptor signaling pathwayGO:0071739.4KIT, SH3KBP1
2regulation of cell shapeGO:0083609.3KIT, SH3KBP1
3Fc-epsilon receptor signaling pathwayGO:0380959.0KIT, FCER1A

Products for genes affiliated with Mast-Cell Leukemia

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  • Antibodies
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Sources for Mast-Cell Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet