MCID: MST002
MIFTS: 35

Mast-Cell Leukemia malady

Cancer diseases category
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Summaries for Mast-Cell Leukemia

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Disease Ontology:8 A leukemia that results in an overwhelming number of tissue mast cells located in peripheral blood.

MalaCards based summary: Mast-Cell Leukemia, also known as leukemia, mast-cell, is related to systemic mastocytosis and urticaria. An important gene associated with Mast-Cell Leukemia is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and Signaling by FGFR. The compound histamine have been mentioned in the context of this disorder. Affiliated tissues include peripheral blood, myeloid and bone marrow, and related mouse phenotypes are integument and hematopoietic system.

Aliases & Classifications for Mast-Cell Leukemia

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Mast-Cell Leukemia, Aliases & Descriptions:

Name: Mast-Cell Leukemia 8
 
Leukemia, Mast-Cell 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:9254
NCIt39 C3169
MeSH34 D007946

Related Diseases for Mast-Cell Leukemia

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Diseases related to Mast-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 22)
idRelated DiseaseScoreTop Affiliating Genes
1systemic mastocytosis30.7PSTPIP2, SH3KBP1
2urticaria30.5FCER1A
3leukemia11.0
4mastocytosis10.7
5aleukemic mast cell leukemia10.5
6myeloid leukemia10.4
7acute myeloid leukemia10.4
8aggressive systemic mastocytosis10.3
9cutaneous mastocytosis10.3
10classic mast cell leukemia10.3
11asthma10.1
12hematopoietic stem cell transplantation10.1
13hypertension10.1
14mast-cell sarcoma10.1
15sm-ahnmd10.1
16urticaria pigmentosa10.1
17portal hypertension10.1
18histiocytosis10.1
19monocytic leukemia10.1
20sarcoma10.1
21back pain10.1
22acute basophilic leukemia10.1

Graphical network of the top 20 diseases related to Mast-Cell Leukemia:



Diseases related to mast-cell leukemia

Symptoms for Mast-Cell Leukemia

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Drugs & Therapeutics for Mast-Cell Leukemia

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Drug clinical trials:

Search ClinicalTrials for Mast-Cell Leukemia

Search NIH Clinical Center for Mast-Cell Leukemia

Genetic Tests for Mast-Cell Leukemia

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Anatomical Context for Mast-Cell Leukemia

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MalaCards organs/tissues related to Mast-Cell Leukemia:

32
Myeloid, Bone marrow, Bone, Monocytes

FMA organs/tissues related to Mast-Cell Leukemia:

14
Peripheral blood

Animal Models for Mast-Cell Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Mast-Cell Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6SH3KBP1, PSTPIP2, KIT
2MP:00053977.9SH3KBP1, FCER1A, PSTPIP2, KIT
3MP:00053877.7SH3KBP1, FCER1A, PSTPIP2, KIT

Publications for Mast-Cell Leukemia

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Articles related to Mast-Cell Leukemia:

(show top 50)    (show all 56)
idTitleAuthorsYear
1
Mast cell leukemia with prolonged survival on PKC412/midostaurin. (25031773)
2014
2
Chronic mast cell leukemia (MCL) with KIT S476I: a rare entity defined by leukemic expansion of mature mast cells and absence of organ damage. (25209843)
2014
3
Mast cell leukemia associated with undefined morphology and chronic basophilic leukemia. (25264491)
2014
4
Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal. (24675021)
2014
5
Mast cell leukemia: an extremely rare disease. (25028296)
2014
6
FLAG-induced remission in a patient with acute mast cell leukemia (MCL) exhibiting t(7;10)(q22;q26) and KIT D816H. (24596674)
2014
7
Sustained paranoid psychosis in a patient with mast cell leukemia and decreased serotonin level. (23793328)
2013
8
A case of de novo aleukemic mast cell leukemia without c-KIT mutations in exons 8 and 17. (24034180)
2013
9
A case of systemic mastocytosis associated with acute myeloid leukemia terminating as aleukemic mast cell leukemia after allogeneic hematopoietic stem cell transplantation. (23483057)
2013
10
Aleukemic variant of mast cell leukemia. (22482127)
2012
11
Mast-cell leukemia exome sequencing reveals a mutation in the IgE mast-cell receptor I^ chain and KIT V654A. (22173243)
2012
12
Systemic mastocytosis: progressive evolution of an occult disease into fatal mast cell leukemia: unique findings on an unusual hematological neoplasm. (22661384)
2012
13
Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor. (22324351)
2012
14
Death from mast cell leukemia: a young patient with longstanding cutaneous mastocytosis evolving into fatal mast cell leukemia. (22329485)
2012
15
Aberrant expression of CD30 in aggressive systemic mastocytosis and mast cell leukemia: a differential diagnosis to consider in aggressive hematopoietic CD30-positive neoplasms. (21261503)
2011
16
Inhibition of JAK-STAT signaling by TG101348: a novel mechanism for inhibition of KITD816V-dependent growth in mast cell leukemia cells. (20485374)
2010
17
Myelomastocytic leukemia versus mast cell leukemia versus systemic mastocytosis associated with acute myeloid leukemia: a diagnostic challenge. (20658589)
2010
18
The classification of systemic mastocytosis should include mast cell leukemia (MCL) and systemic mastocytosis with a clonal hematologic non-mast cell lineage disease (SM-AHNMD). (20688965)
2010
19
Mast cell leukemia with rapidly progressing portal hypertension. (19883434)
2009
20
Mast cell leukemia: a report of ten cases. (18172645)
2008
21
KIT regulates tyrosine phosphorylation and nuclear localization of beta-catenin in mast cell leukemia. (17949810)
2008
22
Cladribine therapy in a patient with an aleukemic subvariant of mast cell leukemia. (15928938)
2005
23
Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. (15972446)
2005
24
Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras. (15735740)
2005
25
Aleukemic mast cell leukemia with abnormal immunophenotype and c-kit mutation D816V. (15512820)
2004
26
Malignant hematopoietic cell lines: in vitro models for the study of mast cell leukemia. (12801523)
2003
27
Mast cell leukemia. (12564414)
2003
28
Induction of apoptosis in the human mast cell leukemia cell line HMC-1 by various antineoplastic drugs. (12688323)
2003
29
Rapid engraftment of mast cells of donor origin in a case of acute myeloid leukemia with mast cell leukemia after allogeneic stem cell transplantation. (12815487)
2003
30
RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. (11956218)
2002
31
Low back pain and myalgias in acute and relapsed mast cell leukemia: a case report. (12048668)
2002
32
Mast cell leukemia--a rare form of myeloid leukemia. (12238304)
2002
33
Synaptotagmin I expression in mast cells of normal human tissues, systemic mast cell disease, and a human mast cell leukemia cell line. (11181737)
2001
34
Connective tissue-type mast cell leukemia in a dog. (10720189)
2000
35
Expression of Bcl-2 by human bone marrow mast cells and its overexpression in mast cell leukemia. (10072109)
1999
36
Sequential immunophenotypic analysis of mast cells in a case of systemic mast cell disease evolving to a mast cell leukemia. (9149916)
1997
37
Expression of multiple chemokine genes by a human mast cell leukemia. (8188667)
1994
38
Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line. (7512180)
1994
39
Identification of mutations in the coding sequence of the proto- oncogene c-kit in a human mast cell leukemia cell line causing ligand- independent activation of c-kit product. (7691885)
1993
40
Establishment of an immature mast cell line from a patient with mast cell leukemia. (3131594)
1988
41
Mast cell leukemia and acute basophilic leukemia. Cytochemical studies. (747630)
1978
42
An approach to immunotherapy using antibody to IgE in mast cell leukemia. (1082794)
1976
43
Canine mast cell leukemia. (4376378)
1970
44
Cellular and cell-free transmission of a canine mast cell leukemia. (5674816)
1968
45
Cytology of viable blood cells of tissue mast cell leukemia. (5322365)
1966
46
Relation of mastocytoma to mast cell leukemia, and of heparin, histamine and serotonin to mast cells. (13651348)
1959
47
Tissue mast cell leukemia. (13499582)
1958
48
Mast cell leukemia? Malignant mastocytosis with leukemia-like manifestations. (13471655)
1957
49
Basophilic (myelocyte) or mast cell leukemia in a cat. (13416054)
1957
50
Mast cell leukemia presenting as urticaria pigmentosa; report of a case. (13441358)
1957

Variations for Mast-Cell Leukemia

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Expression for genes affiliated with Mast-Cell Leukemia

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Expression patterns in normal tissues for genes affiliated with Mast-Cell Leukemia

Search GEO for disease gene expression data for Mast-Cell Leukemia.

Pathways for genes affiliated with Mast-Cell Leukemia

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Pathways related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4SH3KBP1, KIT
2
Show member pathways
9.4SH3KBP1, KIT
3
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)37
9.4SH3KBP1, KIT
49.4KIT, SH3KBP1
59.4SH3KBP1, KIT
69.4SH3KBP1, KIT
7
Show member pathways
9.3FCER1A, KIT

Compounds for genes affiliated with Mast-Cell Leukemia

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Sources:
44Novoseek, 28IUPHAR, 24HMDB
See all sources

Compounds related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1histamine44 28 2411.3KIT, FCER1A

GO Terms for genes affiliated with Mast-Cell Leukemia

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Cellular components related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoskeletonGO:0058569.1PSTPIP2, SH3KBP1
2external side of plasma membraneGO:0098979.0KIT, FCER1A

Biological processes related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor receptor signaling pathwayGO:0071739.4KIT, SH3KBP1
2regulation of cell shapeGO:0083609.3KIT, SH3KBP1
3Fc-epsilon receptor signaling pathwayGO:0380959.0KIT, FCER1A

Products for genes affiliated with Mast-Cell Leukemia

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  • Antibodies
  • Proteins
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Sources for Mast-Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet