Mast-cell Leukemia malady

Wikipedia: Mast cell leukemia is an extremely aggressive subtype of acute myeloid leukemia that usually occurs de...⁴⁴ more...

MalaCards: Mast-cell Leukemia, also known as mast cell leukemia, is related to chronic myeloid leukemia and acute leukemia. An important gene associated with Mast-cell Leukemia is RASGRP4 (RAS guanyl releasing protein 4), and among its related pathways are JNK Pathway and RAR-Gamma-RXR-Alpha Degradation. The drugs isotretinoin and pipobroman and the compounds monochloroacetic acid and pge2 have been mentioned in the context of this disorder. Affiliated tissues include peripheral blood and myeloid, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology: A leukemia that results in an overwhelming number of tissue mast cells located in peripheral blood.⁶

Aliases & Descriptions:

mast-cell leukemia 6 8 mast cell leukemia 7 33 leukemia, mast-cell 43

leukemia mast cell 32 leukemia 43

Diseases related to mast-cell leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 564)

id	Related Disease	Score	Top Affiliating Genes
1	chronic myeloid leukemia	37.6	ISG20, KITLG, CCL3, KIT
2	acute leukemia	37.1	KITLG, CCND1, TNFRSF8, KIT, ISG20
3	lymphoblastic leukemia	36.9	CCL2, KITLG, ISG20, CTNNB1, CCND1, KIT
4	acute lymphoblastic leukemia	36.8	CTNNB1, CCND1, CCL2, ISG20, KITLG, KIT
5	chronic lymphocytic leukemia	36.7	CCL5, CCND1, KITLG, CCL3, PIK3CD, CCL2
6	acute promyelocytic leukemia	36.6	CCL3, CCL5, CCL2, PIK3CD
7	myeloid leukemia	36.1	ISG20, CCL2, CCND1, CCL3, LPXN, CTNNB1
8	acute myeloid leukemia	35.6	CCL2, CCL3, TNFRSF8, CTNNB1, RASGRP4, LPXN
9	lymphocytic leukemia	35.1	TNFRSF8, CCL5, CCL3, CCND1, CTNNB1, PIK3CD
10	adult t-cell leukemia	34.7	CCL2, CCND1, TNFRSF8, CCL3, CCL5
11	leukemia/lymphoma, t-cell	32.5	TNFRSF8, CCND1, KITLG
12	mastocytosis	30.2	TNFRSF8, RASGRP4, KITLG, KIT, PIK3CD
13	b-cell lymphomas	30.2	KIT, CCND1, CCL3, CCL5, TNFRSF8
14	aggressive systemic mastocytosis	30.0	KITLG, KIT
15	mast-cell sarcoma	29.7	KIT, KITLG, ISM1
16	multiple myeloma	28.6	CCL5, CTNNB1, KIT, KITLG, CCND1, TNFRSF8
17	burkitt's lymphoma	28.6	CCL3, KITLG, TNFRSF8, CCND1
18	myeloma	28.5	KITLG, CCL2, CCND1, CCL3, CCL5, TNFRSF8
19	immunodeficiency	28.4	CCL1, CTNNB1, TNFRSF8, CCL5, CCL3, PIK3CD
20	retinoblastoma	28.3	KIT, CCND1, CCL2, KITLG, CTNNB1, PIK3CD
21	t-cell leukemia	27.4	PIK3CD, CCL5, CCL3, CCND1, CCL1, CCL2
22	breast cancer	27.2	CCL3, CCND1, CCL1, CCL2, KITLG, KIT
23	leukemia	27.0	CCL2, ISM1, ISG20, CCL5, PIK3CD, KIT
24	plasmacytoma	27.0	TNFRSF8, CCL3, CCND1
25	multiple sclerosis	27.0	CCL1, CCL5, TNFRSF8, CCL3, CCL2, ISG20
26	carcinoma	26.8	KIT, PIK3CD, LPXN, CCND1, CCL2, CCL3
27	macroglobulinemia	26.8	CCL5, KITLG, CCND1
28	influenza	26.6	CCL2, CCL5, ISG20, PIK3CD, LPXN, CCL3
29	systemic lupus erythematosus	26.4	CCL5, ISG20, CCL2, CCL3
30	prostatitis	26.3	CCL2, CCND1, LPXN, CCL3, CCL5, CTNNB1
31	histiocytosis	26.2	TNFRSF8, KIT, KITLG
32	cytomegalovirus infection	26.0	ISG20, CCL2, CCL5, CCL3
33	gastrointestinal stromal tumor	25.9	CTNNB1, CCND1, KITLG, KIT
34	cutaneous mastocytosis	25.8	KITLG, KIT
35	arthritis	25.8	KIT, CCL3, LPXN, CCL2, KITLG, TNFRSF8
36	asthma	25.7	CCL2, KIT, PIK3CD, CCL1, RASGRP4, CCL3
37	melanoma	25.6	CTNNB1, CCL3, LPXN, KIT, PIK3CD, KITLG
38	lupus erythematosus	25.5	CCL3, CCL2, ISG20, LPXN, PIK3CD, TNFRSF8
39	fibrosis	25.4	CTNNB1, KITLG, KIT, CCL2, CCND1, CCL3
40	hepatitis	25.3	PIK3CD, CCL5, SH3KBP1, KIT, KITLG, ISG20
41	neuroblastoma	25.1	SYT1, CTNNB1, PIK3CD, CCL3, CCL5, CCND1
42	lung carcinoma	25.1	KIT, CCL5, CTNNB1, KITLG, CCL2, CCND1
43	sarcoma	25.0	CCL2, CCL1, CCND1, PIK3CD, CCL5, TNFRSF8
44	cholesterol	24.9	CCL3, CCL5, PIK3CD, SYT1, CTNNB1, KITLG
45	renal cell carcinoma	24.8	CCL2, CTNNB1, CCL3, KITLG, CCND1, KIT
46	waldenstrom macroglobulinemia	24.7	KITLG, CCL5, CCND1
47	paine syndrome	24.7	CCL3, CCL1, CCL2, CCL5
48	hepatocellular carcinoma	24.7	CCL3, CTNNB1, CCL5, CCND1, CCL2, PIK3CD
49	allergic rhinitis	24.7	TNFRSF8, CCL5, CCL1, KITLG
50	hyperlipidemia	24.6	CCL5, CCL3, CCL2, LPXN

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cytarabine, cytarabine liposome, doxorubicin hydrochloride, irinotecan, irinotecan hydrochloride, isotretinoin, methotrexate, methotrexate sodium, pipobroman, vincristine, vincristine sulfate

MalaCards organs/tissues related to mast-cell leukemia:

²²

FMA organs/tissues related to mast-cell leukemia:

¹¹

MGI Mouse Phenotypes related to mast-cell leukemia:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.1	PSTPIP2, SH3KBP1, CCND1, KIT
2	immune system phenotype	MP:0005387	8.1	PIK3CD, PSTPIP2, SH3KBP1, TNFRSF8, CCL3, CCND1
3	digestive/alimentary phenotype	MP:0005381	7.9	CTNNB1, CCL3, CCL2, RASGRP4, KITLG, KIT
4	craniofacial phenotype	MP:0005382	7.7	KIT, KITLG, CCL2, CCND1, CTNNB1, PSTPIP2
5	skeleton phenotype	MP:0005390	7.6	PSTPIP2, CTNNB1, CCND1, RASGRP4, KITLG, KIT
6	integument phenotype	MP:0010771	7.0	PSTPIP2, SH3KBP1, CTNNB1, CCND1, CCL2, KITLG
7	cellular phenotype	MP:0005384	5.9	PSTPIP2, SH3KBP1, CTNNB1, TNFRSF8, CCL5, CCL3

Articles related to mast-cell leukemia:

id	Title	Authors	Year	Affiliating Genes
1	Aberrant expression of CD30 in aggressive systemic ma stocytosis and mast cell leukemia: a differential diagnosis to consider in aggr essive hematopoietic CD30-positive neoplasms. (21261503)	Valent P.... Horny H.P.	2011	TNFRSF8
2	KIT regulates tyrosine phosphorylation and nuclear localization of beta-catenin in mast cell leukemia. (17949810)	Kajiguchi T.... Neckers L.	2008	KIT, CCND1, CTNNB1
3	Establishment of a murine model of aggressive systemic mastocytosis/mast cell leukemia. (16543062)	Demehri S.... Deininger M.W.	2006	KIT
4	Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. (15972446)	Gotlib J.... CoutrAc S.E.	2005	KIT
5	RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. (11956218)	Yang Y.... Stevens R.L.	2002	RASGRP4
6	Synaptotagmin I expression in mast cells of normal human tissues, systemic mast cell disease, and a human mast cell leukemia cell line. (11181737)	Kimura N.... Kimura I.	2001	SYT1
7	Sequential immunophenotypic analysis of mast cells in a case of systemic mast cell disease evolving to a mast cell leukemia. (9149916)	Escribano L.... San Miguel J.F.	1997	ISG20
8	Expression of multiple chemokine genes by a human mast cell leukemia. (8188667)	Selvan R.S.... Krangel M.S.	1994	CCL2, CCL5, CCL3
9	Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line. (7512180)	Kanakura Y.... Kitamura Y.	1994	KITLG
10	Identification of mutations in the coding sequence of the proto- oncogene c-kit in a human mast cell leukemia cell line causing ligand- independent activation of c-kit product. (7691885)	Furitsu T.... Kanakura Y.	1993	KIT, PIK3CD, KITLG

Genes related to mast-cell leukemia according to GeneCards:

(show all 17)

id	Symbol	Description	Score	GeneCards Section Context
1	RASGRP4	RAS guanyl releasing protein 4	11.1	Summaries, Publications
2	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
3	CCL1	chemokine (C-C motif) ligand 1	11.0	Publications
4	ISG20	interferon stimulated exonuclease gene 20kDa	11.0	Publications
5	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0	Publications
6	PSTPIP2	proline-serine-threonine phosphatase interacting protein 2	11.0
7	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	11.0	Publications
8	LPXN	leupaxin	11.0
9	ISM1	isthmin 1 homolog (zebrafish)	11.0
10	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
11	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
12	KITLG	KIT ligand	11.0	Publications
13	SH3KBP1	SH3-domain kinase binding protein 1	11.0
14	CCND1	cyclin D1	11.0	Publications
15	SYT1	synaptotagmin I	11.0	Publications
16	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications
17	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications

Pathways related to mast-cell leukemia according to GeneDecks:

(show all 42)

id	Pathway	Score	Top Affiliating Genes
1	JNK Pathway36	9.9	KIT, KITLG, CCL3
2	RAR-Gamma-RXR-Alpha Degradation36	9.8	CCL1, CCL3, CCL5
3	Acute myeloid leukemia20	9.7	PIK3CD, KIT, CCND1
4	Toll-like receptor signaling pathway20	9.5	PIK3CD, CCL3, CCL5
5	NFAT Signaling and Lymphocyte Interactions36	9.4	CCL2, CCL1, CCL3, CCL5
6	MIF Mediated Glucocorticoid Regulation36	9.4	CCL5, CCL3, CCL1, CCL2
7	PGC1Alpha Pathway36	9.4	CCL5, CCL3, CCL1, CCL2
8	Lymphocyte Signaling3	9.4	KIT, KITLG, CCL5, SH3KBP1
9	MIF Regulation of Innate Immune Cells36	9.4	CCL5, CCL3, CCL1, CCL2
10	Chagas disease (American trypanosomiasis)20	9.3	CCL5, CCL3, CCL2, PIK3CD
11	all-trans-Retinoic Acid Signaling in Brain36	9.3	CCL5, CCL3, CCL1, CCL2
12	PEDF Induced Signaling36	9.3	CCL5, CCL3, CCL1, CCL2
13	SOCS Pathway36	9.3	CCL5, CCL3, CCL1, CCL2
14	Chemokine Signaling36	9.3	CCL5, CCL3, CCL1, CCL2
15	Development_Endothelin-1/EDNRA signaling41	9.3	CTNNB1, CCND1
16	IL-6 Pathway36	9.3	CCL5, CCL3, CCL1, CCL2
17	Regulation of eIF4 and p70S6K36	9.2	CCL5, CCL3, CCL1, CCL2
18	Rheumatoid arthritis20	9.2	CCL2, CCL3, CCL5
19	Glucocorticoid Receptor Signaling36	9.2	CCL5, CCL3, CCL1, CCL2
20	Pathways in cancer20	9.2	CTNNB1, CCND1, PIK3CD
21	Endothelin-1 Signaling Pathway36	9.2	CCL5, CCL3, CCL1, CCL2, KIT
22	STAT3 Pathway36	9.1	CCL2, CCL1, CCL3, CCL5, TNFRSF8
23	Chemokine signaling pathway20	9.1	CCL5, CCL3, CCL1, CCL2, PIK3CD
24	Endometrial cancer20	9.1	PIK3CD, CCND1, CTNNB1
25	Colorectal cancer20	9.0	PIK3CD, CCND1, CTNNB1
26	TGF-Beta Pathway36	9.0	CCL5, CCL3, CCL1, CCL2, KITLG
27	Development Endothelin-1/EDNRA signaling10	9.0	CTNNB1, CCND1, PIK3CD
28	MAPK Family Pathway36	8.9	KITLG, CCL2, CCL1, CCL3, CCL5
29	Prostate cancer20	8.9	CTNNB1, CCND1, PIK3CD
30	PAK Pathway36	8.8	CCL5, CCL3, CCL1, CCL2, KITLG, KIT
31	JAK-STAT Pathway36	8.8	CCL5, CCL3, CCL1, CCL2, KITLG, KIT
32	Rho Family GTPases36	8.8	CCL5, CCL3, CCL1, CCL2, KITLG, KIT
33	Development_VEGF signaling via VEGFR2 - generic cascades41	8.7	CTNNB1, CCL2, PIK3CD
34	Tec Kinases Signaling36	8.7	TNFRSF8, CCL5, CCL3, CCL1, CCL2, KITLG
35	ERK Signaling36	8.7	CCL5, CCL3, CCL1, CCL2, KITLG, KIT
36	Melanogenesis20	8.7	KIT, KITLG, CTNNB1
37	Cytokine-cytokine receptor interaction20	8.6	KIT, TNFRSF8, CCL5, CCL3, CCL1, CCL2
38	Antioxidant Action of Vitamin-C36	8.5	TNFRSF8, CCL5, CCL3, CCL1, CCL2, KITLG
39	p38 Signaling36	8.5	TNFRSF8, CCL5, CCL3, CCL1, CCL2, KITLG
40	Transendothelial Migration of Leukocytes36	8.5	CTNNB1, CCL5, CCL3, CCL1, CCL2
41	Akt Signaling36	8.4	TNFRSF8, CCL5, CCL3, CCND1, CCL1, CCL2
42	Molecular Mechanisms of Cancer36	8.3	CTNNB1, TNFRSF8, CCL5, CCND1, CCL1, KITLG

Compounds related to mast-cell leukemia according to GeneDecks:

(show top 50)    (show all 72)

id	Compound	Score	Top Affiliating Genes
1	monochloroacetic acid32	10.0	KIT, KITLG
2	pge232	10.0	CCL5, CCL3
3	threonine32	9.9	SYT1
4	ginkgolide b32 42	10.8	CCL2, CCL5
5	mcp 132	9.6	CCL5, CCL3, CCL2
6	mip 1alpha32	9.6	CCL2, CCL3, CCL5
7	larc32	9.6	CCL5, CCL3, CCL2
8	mdms32	9.6	CCL5, CCL3, CCL2
9	groalpha32	9.6	CCL2, CCL3, CCL5
10	anaphylatoxin32	9.6	CCL2, CCL3, CCL5
11	triptolide32	9.5	CCL5, CCL3, CCL2
12	sdf 132	9.5	CCL2, CCL5
13	sb-21676332	9.5	CCND1, CTNNB1
14	il 1032	9.5	CCL2, CCL3, CCL5
15	tarc32	9.4	CCL5, CCL3, CCL1, CCL2
16	ccl332	9.4	CCL2, CCL1, CCL3, CCL5
17	ccl432	9.4	CCL5, CCL3, CCL1, CCL2
18	chlorophyllin32	9.4	CCND1, CTNNB1
19	piceatannol32 42 9 9	12.4	CCL2, CCND1, CCL3
20	gm-csf32	9.3	CCL5, CCL3, CCL2, KITLG
21	ly29400232	9.2	CCL5, CCL3, CCND1, CCL2
22	simvastatin32 34 42 9 18 9	14.1	CCL5, CCL3, CCL2, KITLG
23	sb 20358032 42	10.1	CCND1, CCL5, CTNNB1
24	methylcellulose32	9.1	KIT, KITLG, CCL3, CTNNB1
25	trastuzumab32 34 9 9	12.0	CTNNB1, CCL3, CCND1, KIT
26	ribonucleic acid32	9.0	CCL5, CCL3, CCL2, KITLG, KIT
27	rantes32	9.0	CCL5, CCL3, CCL1, CCL2, KITLG
28	imatinib32 34 9 9	11.8	CTNNB1, CCND1, KITLG, KIT
29	gf 109203x32 42	9.7	CTNNB1, CCL5, CCND1, KITLG
30	cytochalasin d32 42	9.7	CTNNB1, CCL5, CCL2, KITLG
31	aspartate32	8.7	CCL3, CTNNB1, SYT1
32	egcg32	8.6	CTNNB1, CCL5, CCND1, CCL2
33	5fluorouracil32	8.6	CTNNB1, CCL3, CCL2, KITLG, KIT
34	nitric oxide32 9 18 9	11.5	CCL5, CCL3, CCL1, CCL2, KITLG, KIT
35	agar32	8.4	CTNNB1, CCND1, KITLG
36	tgf beta132	8.3	CTNNB1, CCL3, CCND1, CCL2, KITLG
37	thymidine32 18	9.3	CTNNB1, TNFRSF8, CCL3, CCND1, KITLG, KIT
38	histamine32 18	9.2	CTNNB1, CCL5, CCL3, CCL2, KITLG, KIT
39	paraffin32	8.1	CTNNB1, TNFRSF8, CCND1, CCL2, KITLG, KIT
40	genistein32 9 18 9	11.1	CTNNB1, CCL5, CCND1, CCL2, KITLG
41	testosterone32 9 18 9	11.0	CTNNB1, CCL3, CCND1, CCL2, KITLG, KIT
42	pd 98,05932	7.7	KIT, KITLG, CCL2, CCND1, CCL3, CCL5
43	lipid32	7.7	SYT1, TNFRSF8, CCL5, CCL2, LPXN, KITLG
44	cycloheximide32	7.7	CTNNB1, CCL5, CCL3, CCND1, CCL2, KITLG
45	vegf32	7.7	CTNNB1, CCL5, CCL3, CCND1, CCL2, KITLG
46	wortmannin32 42	8.6	CTNNB1, CCL5, CCL3, CCND1, CCL2, KITLG
47	phosphatidylinositol32	7.6	SH3KBP1, CTNNB1, CCND1, CCL2, KITLG, KIT
48	calcium32 9 18 9	10.4	SYT1, TNFRSF8, CCL5, CCL3, CCL1, CCL2
49	serine32	7.1	CTNNB1, TNFRSF8, CCL5, CCL3, CCND1, CCL2
50	tyrosine32	6.4	SYT1, SH3KBP1, CTNNB1, TNFRSF8, CCL5, CCND1

Cellular components related to mast-cell leukemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	8.4	KIT, KITLG, CCL2, CCL1, CCL3, CCL5

Biological processes related to mast-cell leukemia according to GeneDecks:

(show all 31)

id	Name	GO ID	Score	Top Affiliating Genes
1	mast cell differentiation	GO:060374	10.3	KIT, PIK3CD
2	mast cell chemotaxis	GO:002551	10.2	PIK3CD, KIT
3	mast cell degranulation	GO:043303	10.2	PIK3CD, KIT
4	T cell chemotaxis	GO:010818	10.1	CCL3, PIK3CD
5	germ cell programmed cell death	GO:035234	10.1	KIT, KITLG
6	positive regulation of natural killer cell chemotaxis	GO:2000503	10.0	CCL5, CCL3
7	astrocyte cell migration	GO:043615	9.9	CCL3, CCL2
8	eosinophil chemotaxis	GO:048245	9.9	CCL3, CCL5
9	response to cholesterol	GO:070723	9.9	CCL3, CCL5
10	positive regulation of macrophage chemotaxis	GO:010759	9.8	CCL2, CCL5
11	positive regulation of JAK-STAT cascade	GO:046427	9.8	CCL5, KIT
12	negative regulation by host of viral transcription	GO:043922	9.8	CCL3, CCL5
13	neutrophil chemotaxis	GO:030593	9.7	CCL3, CCL2, PIK3CD
14	lymphocyte chemotaxis	GO:048247	9.6	CCL5, CCL3, CCL2
15	macrophage chemotaxis	GO:048246	9.6	CCL2, CCL3, CCL5
16	monocyte chemotaxis	GO:002548	9.6	CCL5, CCL3, CCL2
17	cellular response to interferon-gamma	GO:071346	9.6	CCL5, CCL3, CCL2
18	protein kinase B signaling cascade	GO:043491	9.6	CCL5, CCL3, CCL2
19	lipopolysaccharide-mediated signaling pathway	GO:031663	9.6	CCL2, CCL3, CCL5
20	cellular response to interleukin-1	GO:071347	9.6	CCL2, CCL3, CCL5
21	positive regulation of Ras protein signal transduction	GO:046579	9.6	KITLG, RASGRP4
22	cellular response to tumor necrosis factor	GO:071356	9.5	CCL5, CCL3, CCL2
23	MAPK cascade	GO:000165	9.4	CCL5, CCL3, CCL2
24	cellular calcium ion homeostasis	GO:006874	9.4	CCL2, CCL1, CCL3, CCL5
25	chemotaxis	GO:006935	9.3	CCL5, CCL3, CCL1, CCL2
26	regulation of cell shape	GO:008360	9.3	KIT, CCL2, CCL3, SH3KBP1
27	cytoskeleton organization	GO:007010	9.2	CCL2, CCL3, SH3KBP1
28	inflammatory response	GO:006954	9.1	CCL5, CCL3, CCL2, KIT, PIK3CD
29	cellular response to organic cyclic compound	GO:071407	8.8	CCL2, CCL3, CCL5, CTNNB1
30	signal transduction	GO:007165	8.6	TNFRSF8, CCL1, CCL2, LPXN, KITLG, KIT
31	response to drug	GO:042493	8.3	CTNNB1, CCL5, CCND1, CCL2

Molecular functions related to mast-cell leukemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	CCR5 chemokine receptor binding	GO:031730	9.8	CCL5, CCL3
2	phospholipase activator activity	GO:016004	9.7	CCL5, CCL3
3	CCR1 chemokine receptor binding	GO:031726	9.5	CCL3, CCL5
4	chemokine activity	GO:008009	9.1	CCL2, CCL1, CCL3, CCL5
5	protein kinase activity	GO:004672	8.7	CCL2, CCND1, CCL3, CCL5