MCID: MST002
MIFTS: 47

Mast-Cell Leukemia malady

Cancer category

Summaries for Mast-Cell Leukemia

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A leukemia that results in an overwhelming number of tissue mast cells located in peripheral blood.

MalaCards: Mast-Cell Leukemia, also known as leukemia, mast-cell, is related to systemic mastocytosis and mastocytosis. An important gene associated with Mast-Cell Leukemia is FCER1A (Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide), and among its related pathways are Regulation of KIT signaling and C-MYB transcription factor network. The compounds gm-csf and estrogen have been mentioned in the context of this disorder. Affiliated tissues include peripheral blood, bone marrow and myeloid, and related mouse phenotypes are skeleton and digestive/alimentary.

Aliases & Classifications for Mast-Cell Leukemia

Sources:
8Disease Ontology, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

mast-cell leukemia 8
leukemia, mast-cell 61


External Ids:

Disease Ontology8 DOID:9254
MeSH35 D007946
NCIt40 C3169
ICD1025 C94.3

Related Diseases for Mast-Cell Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mast-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1systemic mastocytosis31.0KITLG, KIT
2mastocytosis31.0KITLG, KIT
3acute leukemia30.7KIT, KITLG
4urticaria30.1FCER1A
5urticaria pigmentosa30.1KIT, KITLG
6asthma30.1CCL1, CCL5, CCL2, CCL3, TNFRSF8, KITLG
7t-cell leukemia10.7
8aleukemic mast cell leukemia10.5
9acute myeloid leukemia10.4
10mast-cell sarcoma10.3
11acute t cell leukemia10.3
12aggressive systemic mastocytosis10.3
13classic mast cell leukemia10.3
14portal hypertension10.1
15malignant histiocytosis10.1
16back pain10.1
17hematopoietic stem cell transplantation10.1
18acute basophilic leukemia10.1
19hepatitis c10.0ISG20
20rhinitis10.0CCL5
21pancreatitis10.0KITLG
22malaria10.0CCL5
23indolent systemic mastocytosis10.0ISM1
24atopy10.0CCL5
25germ cell tumors10.0KIT
26human immunodeficiency virus infectious disease10.0CCL3
27plasmacytoma10.0TNFRSF8
28sarcoma10.0KIT, KITLG
29myeloid leukemia10.0KIT, KITLG
30herpes simplex10.0ISG20, CCL5
31osteomyelitis10.0PSTPIP2
32lung cancer10.0CCND1
33osteosarcoma10.0ISG20, TNFRSF8
34gastrointestinal stromal tumor10.0KIT, KITLG
35acute myocardial infarction10.0CCL5, KITLG
36macroglobulinemia, waldenstrom, somatic10.0CCND1
37hepatitis b10.0TNFRSF8, ISG20
38peritonitis10.0CCL2
39bronchiolitis10.0CCL3, CCL5
40neurofibroma10.0KIT, KITLG
41interstitial lung disease10.0CCL2
42malignant glioma10.0ISG20, CCND1
43myocardial infarction10.0CCL3, CCL5
44desmoid tumor10.0KIT, CTNNB1
45piebaldism10.0KIT, KITLG
46retinoblastoma10.0CCND1
47mycosis fungoides10.0TNFRSF8
48diabetes mellitus10.0CCL2
49allergic rhinitis10.0FCER1A, TNFRSF8, CCL5
50influenza10.0LPXN, ISG20, CCL5

Graphical network of the top 20 diseases related to Mast-Cell Leukemia:



Diseases related to mast-cell leukemia

Clinical Features for Mast-Cell Leukemia

Drugs & Therapeutics for Mast-Cell Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Mast-Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Mast-Cell Leukemia

Search NIH Clinical Center for Mast-Cell Leukemia

Search CenterWatch for Mast-Cell Leukemia

Genetic Tests for Mast-Cell Leukemia

Anatomical Context for Mast-Cell Leukemia

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Mast-Cell Leukemia:

33
Bone marrow, Myeloid, Monocytes, T cells, B lymphoblasts, B cells

FMA organs/tissues related to Mast-Cell Leukemia:

14
Peripheral blood

Animal Models for Mast-Cell Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Mast-Cell Leukemia

Sources:
51PubMed
See all sources

Articles related to Mast-Cell Leukemia:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Sustained paranoid psychosis in a patient with mast cell leukemia and decreased serotonin level. (23793328)
2013
2
A case of de novo aleukemic mast cell leukemia without c-KIT mutations in exons 8 and 17. (24034180)
2013
3
A case of systemic mastocytosis associated with acute myeloid leukemia terminating as aleukemic mast cell leukemia after allogeneic hematopoietic stem cell transplantation. (23483057)
2013
4
Mast cell leukemia. (23243287)
2013
5
The transcriptome of the human mast cell leukemia cells HMC-1.2: an approach to identify specific changes in the gene expression profile in KitD816V systemic mastocytosis. (23504229)
2013
6
Mast-cell leukemia exome sequencing reveals a mutation in the IgE mast-cell receptor I^ chain and KIT V654A. (22173243)
2012
7
Systemic mastocytosis: progressive evolution of an occult disease into fatal mast cell leukemia: unique findings on an unusual hematological neoplasm. (22661384)
2012
8
Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor. (22324351)
2012
9
Death from mast cell leukemia: a young patient with longstanding cutaneous mastocytosis evolving into fatal mast cell leukemia. (22329485)
2012
10
Mast cells and eosinophils in mastocytosis, chronic eosinophilic leukemia, and non-clonal disorders. (22449623)
2012
11
Aberrant expression of CD30 in aggressive systemic mastocytosis and mast cell leukemia: a differential diagnosis to consider in aggressive hematopoietic CD30-positive neoplasms. (21261503)
2011
12
Myelomastocytic leukemia versus mast cell leukemia versus systemic mastocytosis associated with acute myeloid leukemia: a diagnostic challenge. (20658589)
2010
13
Mast cell leukemia with rapidly progressing portal hypertension. (19883434)
2009
14
Myc inhibits p27-induced erythroid differentiation of leukemia cells by repressing erythroid master genes without reversing p27-mediated cell cycle arrest. (18838534)
2008
15
The origin of neoplastic mast cells in systemic mastocytosis with AML1/ETO-positive acute myeloid leukemia. (17976525)
2007
16
Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene. (17644741)
2007
17
Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. (16965245)
2006
18
Aleukemic mast cell leukemia with abnormal immunophenotype and c-kit mutation D816V. (15512820)
2004
19
Malignant hematopoietic cell lines: in vitro models for the study of mast cell leukemia. (12801523)
2003
20
Mast cell leukemia. (12564414)
2003
21
Induction of apoptosis in the human mast cell leukemia cell line HMC-1 by various antineoplastic drugs. (12688323)
2003
22
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. (12801524)
2003
23
Rapid engraftment of mast cells of donor origin in a case of acute myeloid leukemia with mast cell leukemia after allogeneic stem cell transplantation. (12815487)
2003
24
Store depletion-activated CaT1 currents in rat basophilic leukemia mast cells are inhibited by 2-aminoethoxydiphenyl borate. Evidence for a regulatory component that controls activation of both CaT1 and CRAC (Ca(2+) release-activated Ca(2+) channel) channels. (12011062)
2002
25
RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. (11956218)
2002
26
Mast cell leukemia--a rare form of myeloid leukemia. (12238304)
2002
27
Synaptotagmin I expression in mast cells of normal human tissues, systemic mast cell disease, and a human mast cell leukemia cell line. (11181737)
2001
28
Connective tissue-type mast cell leukemia in a dog. (10720189)
2000
29
Leukemia inhibitory factor enhances mast cell growth in a mast cell/fibroblast co-culture system through stat3 signaling pathway of fibroblasts. (11150513)
2000
30
c-kit activating mutations and mast cell proliferation in human leukemia. (9657776)
1998
31
In vivo differentiation of mast cells from acute myeloid leukemia blasts carrying a novel activating ligand-independent C-kit mutation. (9714703)
1998
32
Sequential immunophenotypic analysis of mast cells in a case of systemic mast cell disease evolving to a mast cell leukemia. (9149916)
1997
33
Effect of mast cell growth factor on clonogenic blast cell growth in acute myelogenous leukemia. (8774615)
1996
34
Expression of multiple chemokine genes by a human mast cell leukemia. (8188667)
1994
35
Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line. (7512180)
1994
36
Effects of mast cell growth factor on Ara-C mediated acute myeloid leukemia cell killing. (7691332)
1993
37
Identification of mutations in the coding sequence of the proto- oncogene c-kit in a human mast cell leukemia cell line causing ligand- independent activation of c-kit product. (7691885)
1993
38
Circulating mast cells in acute myelomonocytic leukemia with eosinophilia. (8494002)
1993
39
Neoplastic basophil/mast cell precursors from chronic myelogenous leukemia display heterogeneous responses for a hematopoietic factor. (1372056)
1992
40
Mast cell growth factor, a ligand for the receptor encoded by c-kit, affects the growth in culture of the blast cells of acute myeloblastic leukemia. (1711640)
1991
41
Porcine mast cell leukemia with systemic mastocytosis. (2492400)
1989
42
Mast cell leukemia: report of a case and review of the literature. (3095598)
1986
43
The occurrence of a bilateral mandibular mast cell neoplasm in a mouse with lymphocytic leukemia. (117221)
1979
44
Chemotherapy in reticulum-cell sarcoma in five dogs and a cat and in mast-cell leukemia in a cat. (4936153)
1971
45
Canine mast cell leukemia. (4376378)
1970
46
Cytology of viable blood cells of tissue mast cell leukemia. (5322365)
1966
47
Relation of mastocytoma to mast cell leukemia, and of heparin, histamine and serotonin to mast cells. (13651348)
1959
48
Mast cell leukemia? Malignant mastocytosis with leukemia-like manifestations. (13471655)
1957
49
Mast cell leukemia presenting as urticaria pigmentosa; report of a case. (13441358)
1957
50
Urticaria pigmentosa with bone involvement; mast cell aggregates in bones and myelosclerosis found at autopsy in a case dying of monocytic leukemia. (13385542)
1956

Genetic Variations for Mast-Cell Leukemia

Expression for genes affiliated with Mast-Cell Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mast-Cell Leukemia

Search GEO for disease gene expression data for Mast-Cell Leukemia.

Pathways for genes affiliated with Mast-Cell Leukemia

Sources:
54Reactome, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore, 30KEGG, 52QIAGEN, 4Cell Signaling Technology
See all sources

Pathways related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0KITLG, KIT
29.8CCND1, KITLG, KIT
39.7CCND1, CTNNB1, PIK3CD
4
Development A3 receptor signaling
Hide members
9.7PIK3CD, CTNNB1, CCND1
59.7PIK3CD, CCL2, CCL5
69.7CCL2, CCL3
7
Hide members
9.6CCL2, CCL5, CCL1
89.5KIT, KITLG, PIK3CD, CCND1
9
Hide members
9.5KITLG, KIT, RASGRP4, FCER1A
10
Hide members
9.5CCND1, CTNNB1, PIK3CD, KIT
11
Hide members
9.5CCL5, CCND1, CCL2, PIK3CD
12
Hide members
9.4CCL5, CCND1, CCL3
139.4CCL3, CCL2, CCL5
149.4CCL5, CCL2, CCL3
15
Hide members
9.3PIK3CD, KITLG, KIT, RASGRP4, FCER1A
169.3CCND1, CTNNB1, PIK3CD, KITLG, KIT
17
Hide members
9.2FCER1A, SH3KBP1, PIK3CD
18
Hide members
9.2KIT, KITLG, SH3KBP1
19
Hide members
9.0PIK3CD, SH3KBP1, KITLG, KIT
209.0KIT, KITLG, SH3KBP1, CCL5
21
Hide members
8.9PIK3CD, CCL3, CCL2, CCND1, CCL5
22
Hide members
8.9CCL1, CCND1, CCL3, TNFRSF8
23
Hide members
8.9CCL1, CCL5, CCL2, CCL3, PIK3CD
24
Hide members
8.9CTNNB1, CCL3, CCL2, CCL5, CCL1
258.5PIK3CD, SYT1, SH3KBP1, KITLG, KIT
26
Hide members
8.0CCL1, CCL5, CCL2, CCL3, TNFRSF8, KITLG
27
Hide members
8.0CCL1, CCL5, CCL2, CCL3, TNFRSF8, CTNNB1
28
Hide members
7.7FCER1A, CCL1, CCL5, CCND1, CCL2, CCL3
29
Hide members
7.7CCL5, CCL2, CCL3, CTNNB1, PIK3CD, SH3KBP1

Compounds for genes affiliated with Mast-Cell Leukemia

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1gm-csf45 2911.7CCL5
2estrogen4510.5ISG20
3sb-2167634510.2CTNNB1, CCND1
4chlorophyllin4510.2CCND1, CTNNB1
5rantes4510.1KITLG, CCL3
6monochloroacetic acid4510.1KITLG, KIT
7sdf 14510.0CCL2, CCL5
8mcp 1459.8CCL5, CCL2, CCL3
9mip 1alpha459.8CCL5, CCL2, CCL3
10gf 109203x45 6010.8CCND1, KITLG, CCL5, CTNNB1
11larc459.8CCL5, CCL3, CCL2
12mdms459.8CCL2, CCL3, CCL5
13cytochalasin d45 6010.8CCL5, KITLG, CTNNB1, CCL2
14imatinib45 50 1111.8KITLG, CTNNB1, KIT, CCND1
15egcg459.8CCL2, CTNNB1, CCND1, CCL5
16groalpha459.8CCL2, CCL3, CCL5
17anaphylatoxin459.8CCL5, CCL2, CCL3
18triptolide459.7CCL2, CCL3, CCL5
19piceatannol45 60 1111.7CCND1, CCL2, CCL3
20methylcellulose459.7KIT, CCL3, KITLG, CTNNB1
21trastuzumab45 50 1111.6KIT, CTNNB1, CCL3, CCND1
22il 10459.6CCL3, CCL2, CCL5
23serine459.6CCL5, CCND1, CCL2, CCL3
24tarc459.5CCL3, CCL1, CCL5, CCL2
25ccl345 2910.5CCL3, CCL5, CCL1, CCL2
26ccl445 2910.5CCL5, CCL1, CCL2, CCL3
27sp 60012545 6010.5CCND1, CCL3, CCL2, CCL5
28methotrexate45 50 1111.5CCL5, CCND1, KITLG, KIT
29simvastatin45 50 60 29 11 2414.5CCL2, KITLG, CCL3, CCL5
30genistein45 29 60 2 11 2414.5CTNNB1, KITLG, CCL2, CCND1, CCL5
315fluorouracil459.4CCL3, CTNNB1, KITLG, KIT, CCL2
32ribonucleic acid459.4KITLG, CCL2, CCL5, CCL3, KIT
33tgf beta1459.4CTNNB1, CCL3, CCL2, CCND1, KITLG
34aspartate459.3CTNNB1, SYT1, CCL2
35sb 20358045 6010.3CCL2, CCL3, CCND1, CCL5, CTNNB1
36paraffin459.2CCL2, CCND1, TNFRSF8, CTNNB1, KIT, KITLG
37agar459.1KITLG, CCND1, CTNNB1, CCL2
38testosterone45 60 11 2412.1CTNNB1, CCL3, CCL2, CCND1, KITLG, KIT
39histamine45 29 2411.0CCL5, FCER1A, KIT, KITLG, CTNNB1, CCL3
40thymidine45 249.9KIT, KITLG, TNFRSF8, CCL3, CTNNB1, CCND1
41pd 98,059458.9CCL3, CTNNB1, CCND1, KIT, CCL2, KITLG
42ly294002458.9CTNNB1, PIK3CD, CCL3, CCL2, CCND1, CCL5
43wortmannin458.9KITLG, CCL5, PIK3CD, CCND1, CCL3, CTNNB1
44vegf458.9CCL3, CCL2, CCND1, CCL5, CTNNB1, KITLG
45nitric oxide45 11 2410.9CCL1, CCL2, CCL3, KITLG, KIT, CCL5
46threonine458.7CTNNB1, KIT, SYT1, PIK3CD, TNFRSF8, CCND1
47phosphatidylinositol458.6CCL2, SH3KBP1, KIT, KITLG, PIK3CD, CTNNB1
48lipid458.3SYT1, KITLG, CCL5, LPXN, PIK3CD, TNFRSF8
49calcium45 50 11 2410.7PIK3CD, SYT1, KITLG, TNFRSF8, CCL3, CCL2
50tyrosine457.0PIK3CD, LPXN, CCND1, TNFRSF8, ISG20, SYT1

GO Terms for genes affiliated with Mast-Cell Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6KIT, CCL1, CCL5, CCL2, CCL3, KITLG
2cytoplasmGO:0057377.3CCL2, CCL3, TNFRSF8, ISG20, CTNNB1, LPXN
3plasma membraneGO:0058866.6TNFRSF8, CTNNB1, PIK3CD, LPXN, SYT1, SH3KBP1

Biological processes related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1mast cell differentiationGO:06037410.4PIK3CD, KIT
2germ cell programmed cell deathGO:03523410.4KITLG, KIT
3mast cell chemotaxisGO:00255110.3PIK3CD, KIT
4mast cell degranulationGO:04330310.2KIT, PIK3CD
5positive regulation of macrophage chemotaxisGO:01075910.2CCL5, CCL2
6T cell chemotaxisGO:01081810.1CCL3, PIK3CD
7positive regulation of JAK-STAT cascadeGO:04642710.0KIT, CCL5
8positive regulation of natural killer cell chemotaxisGO:200050310.0CCL5, CCL3
9astrocyte cell migrationGO:04361510.0CCL2, CCL3
10Fc-epsilon receptor signaling pathwayGO:0380959.9PIK3CD, KITLG, KIT, FCER1A
11lymphocyte chemotaxisGO:0482479.9CCL2, CCL3
12eosinophil chemotaxisGO:0482459.9CCL3, CCL5
13macrophage chemotaxisGO:0482469.8CCL3, CCL2, CCL5
14monocyte chemotaxisGO:0025489.8CCL5, CCL2, CCL3
15cellular response to interferon-gammaGO:0713469.8CCL3, CCL2, CCL5
16lipopolysaccharide-mediated signaling pathwayGO:0316639.8CCL3, CCL2, CCL5
17cellular response to organic cyclic compoundGO:0714079.8CCL5, CCL2, CCL3
18neutrophil chemotaxisGO:0305939.8PIK3CD, CCL3, CCL2
19protein kinase B signaling cascadeGO:0434919.8CCL5, CCL2, CCL3
20cellular response to interleukin-1GO:0713479.8CCL3, CCL2, CCL5
21negative regulation by host of viral transcriptionGO:0439229.8CCL5, CCL3
22cellular response to tumor necrosis factorGO:0713569.7CCL3, CCL2, CCL5
23MAPK cascadeGO:0001659.7CCL3, CCL2, CCL5
24positive regulation of Ras protein signal transductionGO:0465799.6KITLG, RASGRP4
25cellular calcium ion homeostasisGO:0068749.5CCL3, CCL2, CCL5, CCL1
26chemotaxisGO:0069359.5CCL1, CCL5, CCL2, CCL3
27innate immune responseGO:0450879.5CTNNB1, PIK3CD, KITLG, KIT, FCER1A
28inflammatory responseGO:0069549.4CCL5, CCL2, CCL3, PIK3CD, KIT
29epidermal growth factor receptor signaling pathwayGO:0071739.2PIK3CD, SH3KBP1, KITLG, KIT
30protein phosphorylationGO:0064689.2PIK3CD, CCL3, CCL2, CCL5
31regulation of cell shapeGO:0083609.0CCL2, CCL3, SH3KBP1, KIT
32cytoskeleton organizationGO:0070108.8SH3KBP1, CCL3, CCL2
33signal transductionGO:0071658.7CCL1, CCL2, TNFRSF8, PIK3CD, LPXN, KITLG

Molecular functions related to Mast-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR5 chemokine receptor bindingGO:0317309.7CCL3, CCL5
2CCR1 chemokine receptor bindingGO:0317269.7CCL3, CCL5
3phospholipase activator activityGO:0160049.4CCL3, CCL5
4chemokine activityGO:0080099.2CCL3, CCL2, CCL5, CCL1
5protein kinase activityGO:0046729.1CCL5, CCND1, CCL2, CCL3

Products for genes affiliated with Mast-Cell Leukemia

  • Antibodies
  • Proteins
  • Lysates
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Sources for Mast-Cell Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet