MCID: MST004
MIFTS: 32

Mast Cell Neoplasm malady

Summaries for Mast Cell Neoplasm

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33MalaCards
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MalaCards: Mast Cell Neoplasm, also known as mastocytoma, is related to mastocytosis and systemic mastocytosis. An important gene associated with Mast Cell Neoplasm is MMP10 (matrix metallopeptidase 10 (stromelysin 2)), and among its related pathways is Regulation of thyroid hormone activity. The compounds tyrosine and polysaccharide have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and digestive/alimentary.

Aliases & Classifications for Mast Cell Neoplasm

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8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

mast cell neoplasm 8 10 61
mastocytoma 8 45
mast cell proliferative disease 8
mast cell tumor nos 8
benign mastocytoma 61
mastocytoma nos 8


External Ids:

Disease Ontology8 DOID:3664
NCIt40 C9295

Related Diseases for Mast Cell Neoplasm

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Mast Cell Neoplasm:



Diseases related to mast cell neoplasm

Clinical Features for Mast Cell Neoplasm

Drugs & Therapeutics for Mast Cell Neoplasm

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mast Cell Neoplasm

Anatomical Context for Mast Cell Neoplasm

Animal Models for Mast Cell Neoplasm or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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Publications for Mast Cell Neoplasm

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51PubMed
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Articles related to Mast Cell Neoplasm:

(show all 14)
idTitleAuthorsYear
1
Pediatric mast cell sarcoma of temporal bone with novel L799F (2395 C>T) KIT mutation, mimicking histiocytic neoplasm. (23388130)
2013
2
Systemic mastocytosis: progressive evolution of an occult disease into fatal mast cell leukemia: unique findings on an unusual hematological neoplasm. (22661384)
2012
3
Aberrant expression of CD30 in aggressive systemic mastocytosis and mast cell leukemia: a differential diagnosis to consider in aggressive hematopoietic CD30-positive neoplasms. (21261503)
2011
4
Involvement of mast cells by the malignant process in patients with Philadelphia chromosome negative myeloproliferative neoplasms. (19387466)
2009
5
On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts. (15291805)
2004
6
Systemic mastocytosis and other mast cell neoplasms. (10444157)
1999
7
Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms. (9989791)
1999
8
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. (8589724)
1996
9
The occurrence of a bilateral mandibular mast cell neoplasm in a mouse with lymphocytic leukemia. (117221)
1979
10
Biochemical and morphologic changes in a mast-cell neoplasm during treatment with cyclophosphamide. (14472639)
1961
11
Biochemical and morphologic heterogeneity in a transplantable mast-cell neoplasm. (14472640)
1961
12
Biologic studies on the development of DON resistance in a mast-cell neoplasm of the mouse. (14434476)
1959
13
Biologic studies on the development of DON resistance in a mast-cell neoplasm of the mouse. (13673276)
1959
14
A transplantable mast-cell neoplasm in the mouse. (13416911)
1957

Genetic Variations for Mast Cell Neoplasm

Expression for genes affiliated with Mast Cell Neoplasm

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mast Cell Neoplasm

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Pathways for genes affiliated with Mast Cell Neoplasm

Sources:
54Reactome, 38NCBI BioSystems Database
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Pathways related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0TPH1, HDC

Compounds for genes affiliated with Mast Cell Neoplasm

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45Novoseek
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Compounds related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine458.6HLA-B, HDC, MITF, IL2, KIT, THY1
2polysaccharide458.4GCNT2, GCNT1, HLA-B, TSTA3

GO Terms for genes affiliated with Mast Cell Neoplasm

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16Gene Ontology
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Cellular components related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi membraneGO:0001398.3HLA-B, NDST3, GCNT1, GCNT4, GCNT2

Biological processes related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.0KIT, IL2
2bone remodelingGO:0468499.7TPH1, MITF
3tissue morphogenesisGO:0487299.4GCNT1, GCNT4
4kidney morphogenesisGO:0609939.3GCNT1, GCNT4

Molecular functions related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activityGO:0081099.9GCNT4, GCNT2
2beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activityGO:0038299.1GCNT1, GCNT4

Products for genes affiliated with Mast Cell Neoplasm

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Sources for Mast Cell Neoplasm

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet