MCID: MST004
MIFTS: 40

Mast Cell Neoplasm malady

Cancer diseases, Blood diseases categories

Summaries for Mast Cell Neoplasm

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34MalaCards
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MalaCards: Mast Cell Neoplasm, also known as mastocytoma, is related to mastocytosis and cutaneous mastocytoma. An important gene associated with Mast Cell Neoplasm is MMP10 (matrix metallopeptidase 10 (stromelysin 2)), and among its related pathways are Melanocyte Development and Pigmentation and O-linked glycosylation of mucins. The compounds sunitinib and 2-chlorodeoxyadenosine have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and normal.

Aliases & Classifications for Mast Cell Neoplasm

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63UMLS, 9Disease Ontology, 11DISEASES, 46Novoseek, 59SNOMED-CT, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Aliases & Descriptions:

mast cell neoplasm 9 11 63
mastocytoma 9 46
mast cell proliferative disease 9
mast cell tumor nos 9
benign mastocytoma 63
mastocytoma nos 9


External Ids:

Disease Ontology9 DOID:3664
NCIt41 C9295
ICD1026 C96.2

Related Diseases for Mast Cell Neoplasm

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Mast Cell Neoplasm:



Diseases related to mast cell neoplasm

Symptoms for Mast Cell Neoplasm

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Drugs & Therapeutics for Mast Cell Neoplasm

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mast Cell Neoplasm

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Anatomical Context for Mast Cell Neoplasm

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Animal Models for Mast Cell Neoplasm or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Mast Cell Neoplasm:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6GCNT1, GCNT2, GCNT4, KIT
2MP:00028738.1MMP10, MITF, KIT, GCNT4, GCNT1
3MP:00053817.7TSTA3, IL2, KIT, GCNT4, GCNT1, NDST3
4MP:00053767.5TPH1, TSTA3, MITF, IL2, KIT, GCNT4
5MP:00053977.1TSTA3, MITF, IL2, KIT, GCNT4, GCNT2
6MP:00053866.9NDST3, TPH1, TSTA3, MITF, IL2, KIT
7MP:00053876.9MMP10, TSTA3, MITF, IL2, KIT, GCNT4

Publications for Mast Cell Neoplasm

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53PubMed
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Articles related to Mast Cell Neoplasm:

idTitleAuthorsYear
1
On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts. (15291805)
2004
2
Systemic mastocytosis and other mast cell neoplasms. (10444157)
1999
3
Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms. (9989791)
1999
4
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. (8589724)
1996
5
The occurrence of a bilateral mandibular mast cell neoplasm in a mouse with lymphocytic leukemia. (117221)
1979
6
Biochemical and morphologic changes in a mast-cell neoplasm during treatment with cyclophosphamide. (14472639)
1961
7
Biochemical and morphologic heterogeneity in a transplantable mast-cell neoplasm. (14472640)
1961
8
Biologic studies on the development of DON resistance in a mast-cell neoplasm of the mouse. (14434476)
1959
9
Biologic studies on the development of DON resistance in a mast-cell neoplasm of the mouse. (13673276)
1959
10
A transplantable mast-cell neoplasm in the mouse. (13416911)
1957

Variations for Mast Cell Neoplasm

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Expression for genes affiliated with Mast Cell Neoplasm

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mast Cell Neoplasm

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Pathways for genes affiliated with Mast Cell Neoplasm

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51PathCards, 54QIAGEN, 56Reactome, 31KEGG
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Pathways related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9KIT, MITF
2
Show member pathways
9.2GCNT1, GCNT4
3
Show member pathways
7.7NDST3, TPH1, TSTA3, GCNT4, GCNT2, GCNT1

Compounds for genes affiliated with Mast Cell Neoplasm

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46Novoseek, 52PharmGKB, 12DrugBank
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Compounds related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sunitinib46 52 1212.0KIT, IL2
22-chlorodeoxyadenosine4610.0KIT, IL2
3con a469.9GCNT2, IL2
4neopterin469.9IL2, TPH1
5sorafenib46 52 1211.9KIT, IL2
6isoleucine469.8KIT, TPH1
7trastuzumab46 52 1211.6KIT, IL2
8polysaccharide468.9TSTA3, GCNT2, GCNT1

GO Terms for genes affiliated with Mast Cell Neoplasm

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17Gene Ontology
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Cellular components related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.8GCNT1, KIT, IL2, MMP10
2Golgi membraneGO:0001398.1NDST3, GCNT1, GCNT2, GCNT4

Biological processes related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1bone remodelingGO:04684910.0MITF, TPH1
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9KIT, IL2
3T cell differentiationGO:0302179.9IL2, KIT
4melanocyte differentiationGO:0303189.8KIT, MITF
5positive regulation of cell proliferationGO:0082849.5GCNT2, KIT, IL2
6tissue morphogenesisGO:0487299.4GCNT1, GCNT4
7kidney morphogenesisGO:0609939.4GCNT1, GCNT4
8O-glycan processingGO:0162668.9GCNT1, GCNT4

Molecular functions related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activityGO:0081099.7GCNT2, GCNT4
2beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activityGO:0038298.9GCNT1, GCNT4

Products for genes affiliated with Mast Cell Neoplasm

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mast Cell Neoplasm

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet