MCID: MST004
MIFTS: 37

Mast Cell Neoplasm malady

Cancer diseases category

Summaries for Mast Cell Neoplasm

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MalaCards: Mast Cell Neoplasm, also known as mastocytoma, is related to systemic mastocytosis and mastocytosis. An important gene associated with Mast Cell Neoplasm is MMP10 (matrix metallopeptidase 10 (stromelysin 2)), and among its related pathways is Regulation of thyroid hormone activity. The compounds tyrosine and polysaccharide have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are homeostasis/metabolism and digestive/alimentary.

Aliases & Classifications for Mast Cell Neoplasm

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60UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mast cell neoplasm 8 10 60
mastocytoma 8 44
mast cell proliferative disease 8
mast cell tumor nos 8
benign mastocytoma 60
mastocytoma nos 8


External Ids:

Disease Ontology8 DOID:3664
NCIt39 C9295
ICD1025 C96.2

Related Diseases for Mast Cell Neoplasm

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Mast Cell Neoplasm:



Diseases related to mast cell neoplasm

Clinical Features for Mast Cell Neoplasm

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Drugs & Therapeutics for Mast Cell Neoplasm

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mast Cell Neoplasm

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Anatomical Context for Mast Cell Neoplasm

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32MalaCards
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MalaCards organs/tissues related to Mast Cell Neoplasm:

32
Bone

Animal Models for Mast Cell Neoplasm or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mast Cell Neoplasm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.8GCNT4, NDST3, HDC, MITF, IL2, KIT
2MP:00053817.7GCNT4, KIT, IL2, NDST3, GCNT1, TSTA3
3MP:00053976.9NDST3, KIT, GCNT2, GCNT4, GCNT1, TSTA3
4MP:00053866.8MITF, HLA-B, TSTA3, HDC, TPH1, KIT
5MP:00053876.8GCNT2, GCNT4, GCNT1, NDST3, TSTA3, KIT

Publications for Mast Cell Neoplasm

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50PubMed
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Articles related to Mast Cell Neoplasm:

(show all 14)
idTitleAuthorsYear
1
Pediatric mast cell sarcoma of temporal bone with novel L799F (2395 C>T) KIT mutation, mimicking histiocytic neoplasm. (23388130)
2013
2
Systemic mastocytosis: progressive evolution of an occult disease into fatal mast cell leukemia: unique findings on an unusual hematological neoplasm. (22661384)
2012
3
Aberrant expression of CD30 in aggressive systemic mastocytosis and mast cell leukemia: a differential diagnosis to consider in aggressive hematopoietic CD30-positive neoplasms. (21261503)
2011
4
Involvement of mast cells by the malignant process in patients with Philadelphia chromosome negative myeloproliferative neoplasms. (19387466)
2009
5
On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts. (15291805)
2004
6
Systemic mastocytosis and other mast cell neoplasms. (10444157)
1999
7
Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms. (9989791)
1999
8
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. (8589724)
1996
9
The occurrence of a bilateral mandibular mast cell neoplasm in a mouse with lymphocytic leukemia. (117221)
1979
10
Biochemical and morphologic changes in a mast-cell neoplasm during treatment with cyclophosphamide. (14472639)
1961
11
Biochemical and morphologic heterogeneity in a transplantable mast-cell neoplasm. (14472640)
1961
12
Biologic studies on the development of DON resistance in a mast-cell neoplasm of the mouse. (14434476)
1959
13
Biologic studies on the development of DON resistance in a mast-cell neoplasm of the mouse. (13673276)
1959
14
A transplantable mast-cell neoplasm in the mouse. (13416911)
1957

Genetic Variations for Mast Cell Neoplasm

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Expression for genes affiliated with Mast Cell Neoplasm

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mast Cell Neoplasm

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Pathways for genes affiliated with Mast Cell Neoplasm

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0TPH1, HDC

Compounds for genes affiliated with Mast Cell Neoplasm

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44Novoseek
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Compounds related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine448.6HDC, MITF, IL2, KIT, THY1, TPH1
2polysaccharide448.4TSTA3, HLA-B, GCNT1, GCNT2

GO Terms for genes affiliated with Mast Cell Neoplasm

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16Gene Ontology
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Cellular components related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi membraneGO:0001398.3HLA-B, NDST3, GCNT1, GCNT4, GCNT2

Biological processes related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.0KIT, IL2
2bone remodelingGO:0468499.7TPH1, MITF
3tissue morphogenesisGO:0487299.4GCNT1, GCNT4
4kidney morphogenesisGO:0609939.3GCNT1, GCNT4

Molecular functions related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activityGO:0081099.9GCNT4, GCNT2
2beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activityGO:0038299.1GCNT1, GCNT4

Products for genes affiliated with Mast Cell Neoplasm

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mast Cell Neoplasm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet