MCID: MST004
MIFTS: 40

Mast Cell Neoplasm malady

Cancer diseases category
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Summaries for Mast Cell Neoplasm

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Disease Ontology:8 A hematologic cancer that has material basis in mast cells.

MalaCards based summary: Mast Cell Neoplasm, also known as mast cell proliferative disease, is related to mastocytosis and cutaneous mastocytoma. An important gene associated with Mast Cell Neoplasm is MMP10 (matrix metallopeptidase 10 (stromelysin 2)), and among its related pathways are Melanocyte Development and Pigmentation and O-linked glycosylation of mucins. The compounds sunitinib and 2-chlorodeoxyadenosine have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and normal.

Aliases & Classifications for Mast Cell Neoplasm

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Sources:
62UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek, 57SNOMED-CT, 39NCIt, 25ICD10
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Mast Cell Neoplasm, Aliases & Descriptions:

Name: Mast Cell Neoplasm 8 10 62
Mast Cell Proliferative Disease 8 62
Mast Cell Tumor 8 62
 
Mastocytoma 8 44
Benign Mastocytoma 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:3664
NCIt39 C9295
ICD1025 C96.2

Related Diseases for Mast Cell Neoplasm

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Graphical network of the top 20 diseases related to Mast Cell Neoplasm:



Diseases related to mast cell neoplasm

Symptoms for Mast Cell Neoplasm

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Drugs & Therapeutics for Mast Cell Neoplasm

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Drug clinical trials:

Search ClinicalTrials for Mast Cell Neoplasm

Search NIH Clinical Center for Mast Cell Neoplasm

Genetic Tests for Mast Cell Neoplasm

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Anatomical Context for Mast Cell Neoplasm

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Animal Models for Mast Cell Neoplasm or affiliated genes

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MGI Mouse Phenotypes related to Mast Cell Neoplasm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6KIT, GCNT4, GCNT2, GCNT1
2MP:00028738.1MITF, KIT, GCNT4, GCNT1, MMP10
3MP:00053817.7IL2, NDST3, GCNT1, GCNT4, KIT, TSTA3
4MP:00053767.5NDST3, MITF, TSTA3, TPH1, KIT, GCNT4
5MP:00053977.1MITF, IL2, KIT, GCNT4, GCNT2, NDST3
6MP:00053866.9MITF, TPH1, TSTA3, IL2, NDST3, GCNT1
7MP:00053876.9NDST3, GCNT1, GCNT4, KIT, IL2, MITF

Publications for Mast Cell Neoplasm

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Articles related to Mast Cell Neoplasm:

idTitleAuthorsYear
1
On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts. (15291805)
2004
2
Systemic mastocytosis and other mast cell neoplasms. (10444157)
1999
3
Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms. (9989791)
1999
4
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. (8589724)
1996
5
The occurrence of a bilateral mandibular mast cell neoplasm in a mouse with lymphocytic leukemia. (117221)
1979
6
Biochemical and morphologic changes in a mast-cell neoplasm during treatment with cyclophosphamide. (14472639)
1961
7
Biochemical and morphologic heterogeneity in a transplantable mast-cell neoplasm. (14472640)
1961
8
Biologic studies on the development of DON resistance in a mast-cell neoplasm of the mouse. (14434476)
1959
9
Biologic studies on the development of DON resistance in a mast-cell neoplasm of the mouse. (13673276)
1959
10
A transplantable mast-cell neoplasm in the mouse. (13416911)
1957

Variations for Mast Cell Neoplasm

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Expression for genes affiliated with Mast Cell Neoplasm

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Expression patterns in normal tissues for genes affiliated with Mast Cell Neoplasm

Search GEO for disease gene expression data for Mast Cell Neoplasm.

Pathways for genes affiliated with Mast Cell Neoplasm

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Pathways related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9KIT, MITF
2
Show member pathways
9.2GCNT1, GCNT4
3
Show member pathways
7.7NDST3, TPH1, TSTA3, GCNT4, GCNT2, GCNT1

Compounds for genes affiliated with Mast Cell Neoplasm

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sunitinib44 50 1112.0KIT, IL2
22-chlorodeoxyadenosine4410.0KIT, IL2
3con a449.9GCNT2, IL2
4neopterin449.9IL2, TPH1
5sorafenib44 50 1111.9KIT, IL2
6isoleucine449.8KIT, TPH1
7trastuzumab44 50 1111.6KIT, IL2
8polysaccharide448.9TSTA3, GCNT2, GCNT1

GO Terms for genes affiliated with Mast Cell Neoplasm

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Cellular components related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.8GCNT1, KIT, IL2, MMP10
2Golgi membraneGO:0001398.1NDST3, GCNT1, GCNT2, GCNT4

Biological processes related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1bone remodelingGO:04684910.0MITF, TPH1
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9KIT, IL2
3T cell differentiationGO:0302179.9IL2, KIT
4melanocyte differentiationGO:0303189.8KIT, MITF
5positive regulation of cell proliferationGO:0082849.5GCNT2, KIT, IL2
6tissue morphogenesisGO:0487299.4GCNT1, GCNT4
7kidney morphogenesisGO:0609939.4GCNT1, GCNT4
8O-glycan processingGO:0162668.9GCNT1, GCNT4

Molecular functions related to Mast Cell Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activityGO:0081099.7GCNT2, GCNT4
2beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activityGO:0038298.9GCNT1, GCNT4

Products for genes affiliated with Mast Cell Neoplasm

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Sources for Mast Cell Neoplasm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet