MCID: MST001
MIFTS: 32

Mast-Cell Sarcoma malady

Blood diseases, Cancer diseases, Rare diseases categories
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Summaries for Mast-Cell Sarcoma

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Wikipedia:65 Mast cell sarcoma is an extremely aggressive form of sarcoma made up of neoplastic mast cells. A sarcoma... more...

MalaCards based summary: Mast-Cell Sarcoma, also known as mast cell sarcoma, is related to leukemia and eosinophilia, and has symptoms including sarcoma, mastocytosis and hepatomegaly/liver enlargement (excluding storage disease). An important gene associated with Mast-Cell Sarcoma is FIP1L1 (factor interacting with PAPOLA and CPSF1). Affiliated tissues include skin, bone and bone marrow.

Aliases & Classifications for Mast-Cell Sarcoma

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 62UMLS, 39NCIt, 34MeSH, 57SNOMED-CT, 27ICD9CM, 63UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
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Mast-Cell Sarcoma, Aliases & Descriptions:

Name: Mast-Cell Sarcoma 8 10 62
 
Mast Cell Sarcoma 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
mast cell sarcoma:
Age of onset: Variable


External Ids:

Disease Ontology8 DOID:355
NCIt39 C9348
MeSH34 D012515
ICD9CM27 202.6
UMLS via Orphanet63 C0036221
MESH via Orphanet35 D012515
ICD10 via Orphanet26 C96.2

Related Diseases for Mast-Cell Sarcoma

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Diseases related to Mast-Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.1FIP1L1, MPO
2eosinophilia29.9FIP1L1, MPO
3sarcoma10.9
4mastocytosis10.4
5systemic mastocytosis10.2
6lymphosarcoma10.2
7sertoli cell tumor10.2
8histiocytoma10.2
9seminoma10.2

Graphical network of diseases related to Mast-Cell Sarcoma:



Diseases related to mast-cell sarcoma

Symptoms for Mast-Cell Sarcoma

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Symptoms:

48 (show all 10)
  • sarcoma
  • mastocytosis
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • mediastinal/hilar adenopathies
  • lymphadenopathy/polyadenopathies
  • bone marrow/medullar infiltration
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness
  • early death/lethality

HPO human phenotypes related to Mast-Cell Sarcoma:

(show all 6)
id Description Frequency HPO Source Accession
1 sarcoma hallmark (90%) HP:0100242
2 mastocytosis hallmark (90%) HP:0100495
3 splenomegaly typical (50%) HP:0001744
4 weight loss typical (50%) HP:0001824
5 hepatomegaly typical (50%) HP:0002240
6 mediastinal lymphadenopathy typical (50%) HP:0100721

Drugs & Therapeutics for Mast-Cell Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Mast-Cell Sarcoma

Search NIH Clinical Center for Mast-Cell Sarcoma

Genetic Tests for Mast-Cell Sarcoma

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Anatomical Context for Mast-Cell Sarcoma

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MalaCards organs/tissues related to Mast-Cell Sarcoma:

32
Skin, Bone, Bone marrow, Liver, Colon, Small intestine, Uterus

Animal Models for Mast-Cell Sarcoma or affiliated genes

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Publications for Mast-Cell Sarcoma

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Articles related to Mast-Cell Sarcoma:

(show all 25)
idTitleAuthorsYear
1
Mast cell sarcoma: clinical management. (24745684)
2014
2
Pediatric mast cell sarcoma of temporal bone with novel L799F (2395 C>T) KIT mutation, mimicking histiocytic neoplasm. (23388130)
2013
3
Mast cell sarcoma mimicking metastatic colon carcinoma. (24141335)
2013
4
Mast cell sarcoma in an infant: a case report and review of the literature. (23211696)
2013
5
Mast cell sarcoma: a rare and potentially under-recognized diagnostic entity with specific therapeutic implications. (23196796)
2013
6
Mast cell sarcoma: a rare and aggressive entity--report of two cases and review of the literature. (23129735)
2013
7
Mast cell sarcoma with megakaryocytic differentiation in a calf. (22813945)
2012
8
Malignant transformation of mastocytoma developed on skin mastocytosis into cutaneous mast cell sarcoma. (22498828)
2012
9
Mast cell sarcoma of the scalp: the first sign of undisclosed systemic mastocytosis? (22963840)
2012
10
Successful treatment of mast cell sarcoma of the uterus with imatinib. (22020400)
2011
11
Mast cell sarcoma of the small intestine: a case report. (21778298)
2011
12
Mast-cell sarcoma of the tibia. (17405977)
2007
13
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. (12801524)
2003
14
Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma. (12826896)
2003
15
Temporary response of localized intracranial mast cell sarcoma to combination chemotherapy. (11216707)
2001
16
Mast cell sarcoma with tissue eosinophilia arising in the ascending colon. (10430280)
1999
17
Association of bone marrow mastocytosis with extremely immature extramedullary mast cell sarcoma]. (9273545)
1997
18
What is your diagnosis? Mast cell sarcoma. (9097238)
1997
19
Brief communication, Histopathology of a spontaneously developing mast cell sarcoma in a Wistar rat. (8736393)
1996
20
Use of hyperthermia and radiotherapy in treatment of a large mast cell sarcoma in a dog. (3145930)
1988
21
Mast cell sarcoma of the larynx. (3088063)
1986
22
Mast cell sarcoma of the larynx in a dog: a case report. (104092)
1979
23
Multiple genital neoplasia (mast cell sarcoma, seminoma, and sertoli cell tumor) in a dog. (13306668)
1956
24
Preliminary observations on the use of cortisone in canine mast cell sarcoma. (13108793)
1953
25
Neoplastic diseases of dogs; mast cell sarcoma, lymphosarcoma, histiocytoma. (18118928)
1948

Variations for Mast-Cell Sarcoma

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Expression for genes affiliated with Mast-Cell Sarcoma

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Expression patterns in normal tissues for genes affiliated with Mast-Cell Sarcoma

Search GEO for disease gene expression data for Mast-Cell Sarcoma.

Pathways for genes affiliated with Mast-Cell Sarcoma

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Compounds for genes affiliated with Mast-Cell Sarcoma

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GO Terms for genes affiliated with Mast-Cell Sarcoma

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Products for genes affiliated with Mast-Cell Sarcoma

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  • Antibodies
  • Proteins
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Sources for Mast-Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet