MCID: MST001
MIFTS: 42

Mast-Cell Sarcoma malady

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Mast-Cell Sarcoma

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Sources:
10Disease Ontology, 12DISEASES, 36MeSH, 65UMLS, 51Orphanet, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Mast-Cell Sarcoma:

Name: Mast-Cell Sarcoma 10 12 36 65
 
Mast Cell Sarcoma 51

Characteristics:

Orphanet epidemiological data:

51
mast cell sarcoma:
Age of onset: All ages

Classifications:



External Ids:

Disease Ontology10 DOID:355
ICD1027 C96.2
ICD9CM29 202.6
MeSH36 D012515
NCIt42 C9348
Orphanet51 66661
ICD10 via Orphanet28 C96.2
MESH via Orphanet37 D012515
UMLS via Orphanet66 C0036221
UMLS65 C0036221

Summaries for Mast-Cell Sarcoma

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Wikipedia:68 Mast cell sarcoma is an extremely aggressive form of sarcoma made up of neoplastic mast cells. A sarcoma... more...

MalaCards based summary: Mast-Cell Sarcoma, also known as mast cell sarcoma, is related to acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) and acute lymphoblastic leukemia congenital sporadic aniridia, and has symptoms including sarcoma, mastocytosis and splenomegaly. An important gene associated with Mast-Cell Sarcoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways are Regulation of KIT signaling and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include skin, bone and bone marrow, and related mouse phenotypes are tumorigenesis and reproductive system.

Related Diseases for Mast-Cell Sarcoma

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Diseases related to Mast-Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)10.6KIT, MPO
2acute lymphoblastic leukemia congenital sporadic aniridia10.5ANPEP, MPO
3exencephaly10.5KIT, KITLG
4malignant teratocarcinosarcoma10.4KIT, VIM
5nodal marginal zone b-cell lymphoma10.4CSF2RA, MPO
6vulvar syringoma10.4KITLG, VIM
7breast papillomatosis10.4KIT, VIM
8cutaneous solitary mastocytoma10.4KIT, PTPRC
9benign mesothelioma10.4KIT, VIM
10extraneural perineurioma10.4KIT, PDGFRA
11external ear squamous cell carcinoma10.4KIT, PTPRC
12severe canavan disease10.3FIP1L1, PDGFRA
13trabecular follicular adenocarcinoma10.3FIP1L1, PDGFRA
14skin carcinoma in situ10.3KIT, MPO, PTPRC
15olfactory nerve disease10.3CMA1, KIT, KITLG
16middle ear disease10.3TNFRSF8, VIM
17adult epithelioid sarcoma10.3KIT, TNFRSF8
18megalocornea10.3KIT, KITLG
19rhinitis10.3KIT, PDGFRA
20diffuse cutaneous mastocytosis10.3CMA1, KIT, KITLG
21scarlet fever10.3MPO, PTPRC
22transient global amnesia10.3CD2, HEXA
23indolent systemic mastocytosis10.3CD2, KIT, PTPRC
24comedo carcinoma10.3KIT, PDGFRA, VIM
25prostate leiomyosarcoma10.3KIT, PDGFRA
26osteogenesis imperfecta-retinopathy-seizures-intellectual disability syndrome10.2FIP1L1, KIT, PDGFRA
27cellular schwannoma10.2KIT, PDGFRA, VIM
28angiokeratoma of mibelli10.2KIT, PDGFRA, VIM
29fallopian tube carcinosarcoma10.2KIT, PDGFRA, VIM
30total anomalous pulmonary venous return10.2KIT, KITLG, PDGFRA
31mixed liposarcoma10.2KIT, VIM
32vesicoureteral reflux10.2KIT, KITLG, PDGFRA
33bartholin's gland small cell carcinoma10.2KIT, PDGFRA, PTPRC
34adenocarcinoma10.2
35hypereosinophilic syndrome, idiopathic, resistant to imatinib10.2IFNA2, KIT, MPO
36nervous system disease10.2PTPRC, TNFRSF8
37adult pulmonary langerhans cell histiocytosis10.2ANPEP, KITLG, PDGFRA
38chromosome 3q29 microduplication syndrome10.2CMA1, FIP1L1, PDGFRA
39lung leiomyosarcoma10.1PDGFRA, PTPRC, VIM
40male reproductive system disease10.1IFNA2, KIT, KITLG
41organ system cancer10.1KIT, PDGFRA, PTPRC
42swayback10.1KIT, PTPRC, TNFRSF8
43ovary leiomyosarcoma10.1KIT, PDGFRA
44herpes simplex encephalitis 110.1ANPEP, FIP1L1, MPO, PTPRC
45ovarian large-cell neuroendocrine carcinoma10.1KIT, PTPRC, TNFRSF8
46pericardial tuberculosis10.1KIT, KITLG, MPO, PDGFRA
47gastrointestinal stromal tumor10.1KIT, KITLG, PDGFRA, VIM
48aggressive systemic mastocytosis10.1CD2, FIP1L1, KIT, PDGFRA
49multiple chemical sensitivity10.1CD2, KIT, KITLG, PDGFRA
50bone benign neoplasm10.1PTPRC, TNFRSF8

Graphical network of the top 20 diseases related to Mast-Cell Sarcoma:



Diseases related to mast-cell sarcoma

Symptoms for Mast-Cell Sarcoma

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Symptoms:

 51 (show all 10)
  • sarcoma
  • mastocytosis
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • mediastinal/hilar adenopathies
  • lymphadenopathy/polyadenopathies
  • bone marrow/medullar infiltration
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness
  • early death/lethality

HPO human phenotypes related to Mast-Cell Sarcoma:

(show all 6)
id Description Frequency HPO Source Accession
1 sarcoma hallmark (90%) HP:0100242
2 mastocytosis hallmark (90%) HP:0100495
3 splenomegaly typical (50%) HP:0001744
4 weight loss typical (50%) HP:0001824
5 hepatomegaly typical (50%) HP:0002240
6 mediastinal lymphadenopathy typical (50%) HP:0100721

Drugs & Therapeutics for Mast-Cell Sarcoma

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Drugs for Mast-Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
CyproheptadineapprovedPhase 315129-03-32913
Synonyms:
1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine
1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine
1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine
129-03-3
4-(5-Dibenzo(a,D)cyclohepten-5-ylidine)-1-methylpiperidine
4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine
4-(5H-Dibenzo(a,D)cyclohepten-5-ylidene)-1-methylpiperidine
4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene
4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine
4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine
4-Dibenzo[a,D]cyclohepten-5-ylidene-1-methyl-piperidine
41354-29-4
5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
5-20-08-00500 (Beilstein Handbook Reference)
AC1L1ER8
AKOS004119847
Axoprol
BIDD:GT0324
BPBio1_000096
BPBio1_000155
BRD-K28143534-001-01-4
BRD-K28143534-003-03-6
BRN 1685976
BSPBio_000086
Biomol-NT_000131
C06935
CAS-969-33-5
CCRIS 5232
CHEBI:4046
CHEMBL516
CID2913
CYPROHEPTADINE
Ciproheptadina
Ciproheptadina [INN-Spanish]
Ciprovit
Ciprovit (TN)
Cypoheptadine
Cyproheptadiene
Cyproheptadin
Cyproheptadine
Cyproheptadine (INN)
 
Cyproheptadine Hcl
Cyproheptadine Hydrochloride
Cyproheptadine [INN:BAN]
Cyproheptadinum
Cyproheptadinum [INN-Latin]
D07765
DB00434
Dibenzosuberonone/Cyproheptadine
Dihexazin
Dronactin
EINECS 204-928-9
Eiproheptadine
Glutodina
HMS2090P20
HSDB 3048
L001016
LS-114933
Lopac-C-6022
Lopac0_000246
MK 141
MolPort-002-507-777
NCGC00015252-01
NCGC00015252-02
NCGC00015252-03
NCGC00015252-09
NCGC00024293-02
NCGC00024293-04
NCGC00024293-05
Oprea1_498140
PDSP1_001229
PDSP2_001213
Periactin
Periactine
Periactinol
Prestwick0_000103
Prestwick1_000103
Prestwick2_000103
Prestwick3_000103
SPBio_002025
STK802098
Tocris-0996
UNII-2YHB6175DO
Viternum
nchembio.559-comp10
2
Histamine PhosphateapprovedPhase 390651-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
EINECS 200-118-4
 
H0147
Histamine Positive Skin Test Control
Histamine Positive skin test control
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
3Neurotransmitter AgentsPhase 314795
4
SerotoninPhase 3314750-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
5Serotonin AgentsPhase 32668
6Serotonin AntagonistsPhase 31175
7Anti-Allergic AgentsPhase 31312
8Histamine H1 AntagonistsPhase 3688
9AntipruriticsPhase 3619
10Histamine AntagonistsPhase 3826
11Dermatologic AgentsPhase 34555
12Gastrointestinal AgentsPhase 36401
13
histaminePhase 390675614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
14Protein Kinase InhibitorsPhase 23162
15Imatinib MesylatePhase 2577123596
16ColaNutraceutical1768

Interventional clinical trials:

idNameStatusNCT IDPhase
1Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for CancerTerminatedNCT01132547Phase 3
2Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare DiseasesCompletedNCT00154388Phase 2
3Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (advSM) and Relapsed or Refractory Myeloid MalignanciesRecruitingNCT02561988Phase 1
4Study of Information Received About Fertility and Infertility in Patients Who Have Finished Treatment for CancerRecruitingNCT01295463
5Evaluation of Patient Satisfaction With and Acceptance of Their Totally-implanted Central Venous CatheterTerminatedNCT01616537
6Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related InfectionWithdrawnNCT00378781

Search NIH Clinical Center for Mast-Cell Sarcoma


Cochrane evidence based reviews: mast-cell sarcoma

Genetic Tests for Mast-Cell Sarcoma

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Anatomical Context for Mast-Cell Sarcoma

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MalaCards organs/tissues related to Mast-Cell Sarcoma:

33
Skin, Bone, Bone marrow, Liver, Myeloid, Breast, Small intestine

Animal Models for Mast-Cell Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Mast-Cell Sarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9CCR5, CXCR4, KIT, KITLG, PDGFRA, PTPRC
2MP:00053897.1ANPEP, C5AR1, CCR5, CXCR4, HEXA, KIT
3MP:00053875.9ANPEP, C5AR1, CCR5, CMA1, CXCR4, KIT
4MP:00053975.9ANPEP, C5AR1, CCR5, CMA1, CXCR4, KIT

Publications for Mast-Cell Sarcoma

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Articles related to Mast-Cell Sarcoma:

(show all 25)
idTitleAuthorsYear
1
Meralgia paresthetica caused by a pancreatic pseudocyst. (25960143)
2015
2
Idiopathic CD4 lymphocytopenia with giant cell arteritis and pulmonary mucormycosis. (25473601)
2014
3
Returning to work after long term sickness absence due to low back pain - the struggle within: A qualitative study of the patient's experience. (23787255)
2013
4
Laparoscopic findings of congenital hepatic fibrosis: A case report and review of the published work. (23730817)
2013
5
Chronic hepatitis E infection cured by pregnancy. (24140032)
2013
6
Estimated prevalence of celiac disease in patients with osteoporosis and osteopenia in Yazd province (Iran). (23256133)
2012
7
Spotted fever group rickettsiae in ticks and fleas from the Democratic Republic of the Congo. (23137572)
2012
8
Prevention of relapse using DLI can increase survival following HLA-identical transplantation in patients with advanced-stage acute leukemia: a multi-center study. (22515260)
2012
9
Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification. (21430068)
2011
10
Functional impairments at school age of children with necrotizing enterocolitis or spontaneous intestinal perforation. (21857378)
2011
11
Three cases of resected pleomorphic carcinoma. (21057444)
2010
12
Lack of association between the 5-HTTLPR and the error-related negativity (ERN). (20920548)
2010
13
Operative treatment of congenital torticollis. (18591606)
2008
14
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. (17384144)
2007
15
Femoral neck fracture in a child with autosomal-dominant osteopetrosis: failure of spica cast treatment and successful outcome by internal fixation. (16056085)
2005
16
Effect of small intestinal submucosa on islet recovery and function in vitro culture. (16286256)
2005
17
No mutation in the KCNE3 potassium channel gene in Chinese thyrotoxic hypokalaemic periodic paralysis patients. (15212652)
2004
18
Osteoprotegerin in human milk: a potential role in the regulation of bone metabolism and immune development. (15155868)
2004
19
Genetics of Parkinson's disease and biochemical studies of implicated gene products. (12231362)
2002
20
A five-year evaluation of intervention in diabetes care in Trinidad and Tobago. (10588524)
1999
21
Cytomegalovirus retinitis and viral resistance: 3. Culture results. CMV Retinitis and Viral Resistance Study Group. (9780099)
1998
22
Thrombospondin-1 (TSP-1) promotes the invasive properties of human breast cancer. (8661169)
1996
23
Sarcoidosis with normocalcemic interstitial nephritis. (7697939)
1995
24
Inactivation of a yeast transactivator by the fused HIV-1 proteinase: a simple assay for inhibitors of the viral enzyme activity. (8244023)
1993
25
Ultrastructure of the middle-ear mucosa in chronic suppurative otitis media. (5032989)
1972

Variations for Mast-Cell Sarcoma

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Expression for genes affiliated with Mast-Cell Sarcoma

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Search GEO for disease gene expression data for Mast-Cell Sarcoma.

Pathways for genes affiliated with Mast-Cell Sarcoma

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Pathways related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathwaysScoreTop Affiliating Genes
110.0KIT, KITLG
29.5IFNA2, KIT, PTPRC
39.4CXCR4, PDGFRA, VIM
49.0ANPEP, KIT, KITLG, MPO
59.0CCR5, CXCR4, KIT, PDGFRA
68.9CXCR4, KIT, PTPRC, TNFRSF8
78.9CSF2RA, CXCR4, KIT, KITLG, PDGFRA
88.7ANPEP, CD2, CSF2RA, KIT, KITLG
98.6ANPEP, CXCR4, KIT, PDGFRA
108.0ANPEP, CD2, IFNA2, KIT, KITLG, MPO
11
Show member pathways
7.7CCR5, CD2, CSF2RA, CXCR4, KIT, KITLG
12
Show member pathways
7.4CCR5, CD2, CSF2RA, CXCR4, KIT, KITLG
13
Show member pathways
7.2CCR5, CD2, CSF2RA, CXCR4, IFNA2, KIT

GO Terms for genes affiliated with Mast-Cell Sarcoma

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Biological processes related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.4IFNA2, KIT
2positive regulation of phospholipase C activityGO:001086310.4KIT, PDGFRA
3glycosphingolipid metabolic processGO:000668710.3HEXA, KIT
4phosphatidylinositol-mediated signalingGO:004801510.1KIT, KITLG, PDGFRA
5positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.1KIT, PDGFRA
6regulation of chemotaxisGO:005092010.0CXCR4, PDGFRA
7fibroblast growth factor receptor signaling pathwayGO:00085439.6CSF2RA, KIT, KITLG, PDGFRA
8cell surface receptor signaling pathwayGO:00071669.4CD2, IFNA2, PTPRC
9insulin receptor signaling pathwayGO:00082869.4CSF2RA, KIT, KITLG, PDGFRA
10vascular endothelial growth factor receptor signaling pathwayGO:00480109.1CSF2RA, KIT, KITLG, PDGFRA
11positive regulation of cytosolic calcium ion concentrationGO:00072048.7C5AR1, CCR5, CXCR4, PDGFRA

Molecular functions related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:00047139.6CSF2RA, KIT, PDGFRA

Sources for Mast-Cell Sarcoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet