MCID: MST001
MIFTS: 35

Mast-Cell Sarcoma

Categories: Blood diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Mast-Cell Sarcoma

MalaCards integrated aliases for Mast-Cell Sarcoma:

Name: Mast-Cell Sarcoma 12 42 14 69
Mast Cell Sarcoma 56

Characteristics:

Orphanet epidemiological data:

56
mast cell sarcoma
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:355
ICD10 33 C96.2
ICD9CM 35 202.6
MeSH 42 D012515
NCIt 47 C9348
Orphanet 56 ORPHA66661
MESH via Orphanet 43 D012515
UMLS via Orphanet 70 C0036221
ICD10 via Orphanet 34 C96.2
UMLS 69 C0036221

Summaries for Mast-Cell Sarcoma

MalaCards based summary : Mast-Cell Sarcoma, also known as mast cell sarcoma, is related to histiocytoma and sarcoma, and has symptoms including splenomegaly, weight loss and hepatomegaly. An important gene associated with Mast-Cell Sarcoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Hematopoietic cell lineage and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and bone, and related phenotype is Increased shRNA abundance (Z-score > 2).

Wikipedia : 72 Mast cell sarcoma is an extremely aggressive form of sarcoma made up of neoplastic mast cells. A sarcoma... more...

Related Diseases for Mast-Cell Sarcoma

Diseases related to Mast-Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
id Related Disease Score Top Affiliating Genes
1 histiocytoma 29.4 KIT VIM
2 sarcoma 10.5
3 malignant teratoma 10.3 ANPEP KIT
4 mannose-binding lectin protein deficiency 10.2 KIT VIM
5 pseudounicornuate uterus 10.2 KIT VIM
6 diffuse meningeal melanocytosis 10.2 KIT VIM
7 alcohol-induced mental disorder 10.2 KIT VIM
8 sebaceous adenoma 10.2 KIT VIM
9 mitral valve stenosis 10.2 ANPEP KIT
10 malignant breast melanoma 10.2 KIT VIM
11 rectal neoplasm 10.2 KIT VIM
12 mesenchymoma 10.1 KIT VIM
13 prostate disease 10.1 KIT VIM
14 myoepithelial carcinoma 10.1 KIT VIM
15 large cell acanthoma 10.1 KIT VIM
16 enamel hypoplasia cataract hydrocephaly 10.1 KIT VIM
17 polyosteolysis/hyperostosis syndrome 10.1 KIT VIM
18 fibula aplasia complex brachydactyly 10.1 KIT VIM
19 acidophil adenoma 10.0 KIT VIM
20 hypoglossal nerve neoplasm 10.0 KIT VIM
21 chikungunya 10.0 KIT VIM
22 acute necrotizing encephalopathy 10.0 KIT MPO
23 mixed extragonadal germ cell cancer 10.0 KIT VIM
24 adenosarcoma 9.9 KIT VIM
25 spermatogenic failure 13 9.9 KIT VIM
26 central nervous system mature teratoma 9.9 ANPEP MPO
27 hypereosinophilic syndrome, idiopathic, resistant to imatinib 9.8 KIT MPO
28 bladder urachal squamous cell carcinoma 9.8 KIT VIM
29 dense deposit disease 9.7 MPO VIM
30 leukemia 9.7
31 systemic mastocytosis 9.7
32 sertoli cell tumor 9.7
33 seminoma 9.7
34 lymphosarcoma 9.7
35 germ cells tumors 9.7
36 preeclampsia/eclampsia 3 9.7 ANPEP MPO
37 mediastinal osteogenic sarcoma 9.7 MPO VIM
38 gastrointestinal stromal tumor 9.7 KIT VIM
39 peroxisome biogenesis disorder 5a 9.5 ANPEP MPO
40 cholesteatoma 9.5 ANPEP KIT MPO
41 nelson syndrome 9.5 ANPEP KIT MPO
42 acute lymphoblastic leukemia, childhood 9.5 ANPEP KIT MPO
43 cranioectodermal dysplasia 1 9.4 ANPEP KIT MPO
44 spinocerebellar ataxia, autosomal recessive 21 9.2 ANPEP MPO
45 pseudomyxoma peritonei 8.3 ANPEP KIT MPO PRKG2 VIM

Graphical network of the top 20 diseases related to Mast-Cell Sarcoma:



Diseases related to Mast-Cell Sarcoma

Symptoms & Phenotypes for Mast-Cell Sarcoma

Human phenotypes related to Mast-Cell Sarcoma:

56 32 (show all 9)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 splenomegaly 56 32 frequent (33%) Frequent (79-30%) HP:0001744
2 weight loss 56 32 frequent (33%) Frequent (79-30%) HP:0001824
3 hepatomegaly 56 32 frequent (33%) Frequent (79-30%) HP:0002240
4 fatigue 56 32 frequent (33%) Frequent (79-30%) HP:0012378
5 sarcoma 56 32 hallmark (90%) Very frequent (99-80%) HP:0100242
6 mastocytosis 56 32 hallmark (90%) Very frequent (99-80%) HP:0100495
7 hypoplasia of the ear cartilage 56 32 frequent (33%) Frequent (79-30%) HP:0100720
8 mediastinal lymphadenopathy 56 32 frequent (33%) Frequent (79-30%) HP:0100721
9 lymphadenopathy 56 Frequent (79-30%)

GenomeRNAi Phenotypes related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.17 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.17 KIT
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.17 VIM
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.17 MPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.17 VIM
6 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.17 KIT
7 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.17 KIT MPO
8 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.17 KIT
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.17 PRKG2 VIM MPO
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.17 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.17 MPO
12 Increased shRNA abundance (Z-score > 2) GR00366-A-188 10.17 PRKG2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-189 10.17 VIM
14 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.17 VIM
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.17 PRKG2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.17 VIM MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.17 VIM KIT
18 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.17 MPO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.17 KIT
20 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.17 PRKG2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-44 10.17 PRKG2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.17 MPO
23 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.17 VIM
24 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.17 MPO
25 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.17 MPO
26 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.17 PRKG2 VIM KIT
27 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.17 KIT
28 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.17 KIT

Drugs & Therapeutics for Mast-Cell Sarcoma

Drugs for Mast-Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
3 Anti-Allergic Agents Phase 3
4 Antipruritics Phase 3
5 Dermatologic Agents Phase 3
6 Gastrointestinal Agents Phase 3
7 Histamine Antagonists Phase 3
8 Histamine H1 Antagonists Phase 3
9
Histamine Phosphate Phase 3 51-74-1 65513
10 Neurotransmitter Agents Phase 3
11
Serotonin Phase 3 50-67-9 5202
12 Serotonin Agents Phase 3
13 Serotonin Antagonists Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Evaluation of Patient Satisfaction With and Acceptance of Their Totally-implanted Central Venous Catheter Terminated NCT01616537

Search NIH Clinical Center for Mast-Cell Sarcoma

Cochrane evidence based reviews: mast-cell sarcoma

Genetic Tests for Mast-Cell Sarcoma

Anatomical Context for Mast-Cell Sarcoma

MalaCards organs/tissues related to Mast-Cell Sarcoma:

39
Skin, Colon, Bone, Uterus, Small Intestine, Bone Marrow

Publications for Mast-Cell Sarcoma

Articles related to Mast-Cell Sarcoma:

(show all 28)
id Title Authors Year
1
Mast cell sarcoma of the sternum, clonally related to an antecedent germ cell tumor with a novel D579del KIT mutation. ( 28236058 )
2017
2
Mast cell sarcoma: new cases and literature review. ( 27602777 )
2016
3
Anaplastic mast cell sarcoma: a unique pathologic entity in mastocytosis. ( 27808598 )
2016
4
Mast cell sarcoma: clinical management. ( 24745684 )
2014
5
Mast cell sarcoma: a rare and aggressive entity--report of two cases and review of the literature. ( 23129735 )
2013
6
Mast cell sarcoma in an infant: a case report and review of the literature. ( 23211696 )
2013
7
Pediatric mast cell sarcoma of temporal bone with novel L799F (2395 C>T) KIT mutation, mimicking histiocytic neoplasm. ( 23388130 )
2013
8
Mast cell sarcoma: a rare and potentially under-recognized diagnostic entity with specific therapeutic implications. ( 23196796 )
2013
9
Mast cell sarcoma mimicking metastatic colon carcinoma. ( 24141335 )
2013
10
Mast cell sarcoma with megakaryocytic differentiation in a calf. ( 22813945 )
2012
11
Malignant transformation of mastocytoma developed on skin mastocytosis into cutaneous mast cell sarcoma. ( 22498828 )
2012
12
Mast cell sarcoma of the scalp: the first sign of undisclosed systemic mastocytosis? ( 22963840 )
2012
13
Successful treatment of mast cell sarcoma of the uterus with imatinib. ( 22020400 )
2011
14
Mast cell sarcoma of the small intestine: a case report. ( 21778298 )
2011
15
Mast-cell sarcoma of the tibia. ( 17405977 )
2007
16
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. ( 12801524 )
2003
17
Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma. ( 12826896 )
2003
18
Temporary response of localized intracranial mast cell sarcoma to combination chemotherapy. ( 11216707 )
2001
19
Mast cell sarcoma with tissue eosinophilia arising in the ascending colon. ( 10430280 )
1999
20
What is your diagnosis? Mast cell sarcoma. ( 9097238 )
1997
21
[Association of bone marrow mastocytosis with extremely immature extramedullary mast cell sarcoma]. ( 9273545 )
1997
22
Brief communication, Histopathology of a spontaneously developing mast cell sarcoma in a Wistar rat. ( 8736393 )
1996
23
Use of hyperthermia and radiotherapy in treatment of a large mast cell sarcoma in a dog. ( 3145930 )
1988
24
Mast cell sarcoma of the larynx. ( 3088063 )
1986
25
Mast cell sarcoma of the larynx in a dog: a case report. ( 104092 )
1979
26
Multiple genital neoplasia (mast cell sarcoma, seminoma, and sertoli cell tumor) in a dog. ( 13306668 )
1956
27
Preliminary observations on the use of cortisone in canine mast cell sarcoma. ( 13108793 )
1953
28
Neoplastic diseases of dogs; mast cell sarcoma, lymphosarcoma, histiocytoma. ( 18118928 )
1948

Variations for Mast-Cell Sarcoma

Expression for Mast-Cell Sarcoma

Search GEO for disease gene expression data for Mast-Cell Sarcoma.

Pathways for Mast-Cell Sarcoma

Pathways related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.24 ANPEP KIT
2 11.2 ANPEP KIT MPO
3 10.88 ANPEP KIT
4 10.69 ANPEP KIT MPO

GO Terms for Mast-Cell Sarcoma

Sources for Mast-Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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