MCID: MST001
MIFTS: 42

Mast-Cell Sarcoma malady

Blood, Cancer categories

Summaries for Mast-Cell Sarcoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Mast cell sarcoma is an extremely aggressive form of sarcoma made up of neoplastic mast cells. A sarcoma... more...

MalaCards: Mast-Cell Sarcoma, also known as mast cell sarcoma, is related to mastocytosis and sertoli cell tumor, and has symptoms including sarcoma, mastocytosis and hepatomegaly/liver enlargement (excluding storage disease). An important gene associated with Mast-Cell Sarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Melanocyte Development and Pigmentation and Regulation of KIT signaling. The compounds cycloheximide and naphthol as-d chloroacetate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, small intestine and colon, and related mouse phenotypes are reproductive system and cardiovascular system.

Aliases & Classifications for Mast-Cell Sarcoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 49Orphanet, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
mast cell sarcoma:
Age of onset: Variable


Aliases & Descriptions:

mast-cell sarcoma 8 10 61
mast cell sarcoma 49


External Ids:

Disease Ontology8 DOID:355
MeSH35 D012515
NCIt40 C9348
ICD9CM27 202.6
MESH via Orphanet36 D012515
ICD10 via Orphanet26 C96.2
SNOMED-CT via Orphanet58 118615008, 13583002, 188660004
UMLS via Orphanet62 C0036221

Related Diseases for Mast-Cell Sarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mast-Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1mastocytosis30.5KIT, KITLG, FIP1L1
2sertoli cell tumor30.2VIM
3systemic mastocytosis30.2KITLG, KIT
4mast-cell leukemia30.2KIT, KITLG, MPO
5lymphosarcoma10.1
6small cell sarcoma10.1
7skin sarcoma10.1
8histiocytic sarcoma10.1
9cutaneous mastocytoma10.1
10indolent systemic mastocytosis10.0ISM1
11urticaria10.0C5AR1
12meningioma10.0VIM
13hepatitis10.0ANPEP
14angiosarcoma10.0VIM
15adult respiratory distress syndrome10.0C5AR1
16germinoma10.0KIT
17uterine carcinosarcoma10.0KIT
18perineurioma10.0VIM
19thymic carcinoma10.0KIT
20atopy10.0MPO
21inflammatory bowel disease10.0MPO
22polycythemia10.0KITLG
23malignant mesothelioma10.0VIM
24hepatocellular carcinoma10.0ANPEP
25allergic rhinitis10.0MPO
26vitiligo10.0KITLG
27stomach cancer10.0ANPEP
28encephalomyelitis10.0ANPEP, C5AR1
29pleurisy10.0MPO
30myelofibrosis10.0FIP1L1
31colorectal cancer10.0KITLG
32peritonitis10.0MPO, C5AR1
33glomerulonephritis10.0C5AR1, MPO
34rheumatoid arthritis10.0C5AR1, MPO
35intestinal disease10.0C5AR1, MPO
36leukostasis10.0MPO, C5AR1
37fibrosarcoma10.0ANPEP, VIM
38acute undifferentiated leukemia10.0MPO, ANPEP
39phyllode tumor10.0VIM, KIT
40endometrial stromal sarcoma10.0KIT, VIM
41malignant mixed mullerian tumor10.0KIT, VIM
42multiple sclerosis10.0KITLG, ANPEP
43adenoma10.0KITLG, ANPEP
44malignant peripheral nerve sheath tumor10.0VIM, KIT
45urticaria pigmentosa10.0KITLG, KIT
46ischemia10.0C5AR1, MPO
47adenoid cystic carcinoma10.0VIM, KIT
48piebaldism10.0KIT, KITLG
49seminoma10.0KIT, KITLG
50dermatofibrosarcoma protuberans10.0KIT, VIM

Graphical network of the top 20 diseases related to Mast-Cell Sarcoma:



Diseases related to mast-cell sarcoma

Clinical Features for Mast-Cell Sarcoma

Sources:
49Orphanet
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Symptoms:

49 (show all 10)
  • sarcoma
  • mastocytosis
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • mediastinal/hilar adenopathies
  • lymphadenopathy/polyadenopathies
  • bone marrow/medullar infiltration
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness
  • early death/lethality

Drugs & Therapeutics for Mast-Cell Sarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mast-Cell Sarcoma

Drug clinical trials:

Search ClinicalTrials for Mast-Cell Sarcoma

Search NIH Clinical Center for Mast-Cell Sarcoma

Search CenterWatch for Mast-Cell Sarcoma

Genetic Tests for Mast-Cell Sarcoma

Anatomical Context for Mast-Cell Sarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Mast-Cell Sarcoma:

33
Bone marrow, Small intestine, Colon, Skin, Uterus, T cells

Animal Models for Mast-Cell Sarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Mast-Cell Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.2ANPEP, KITLG
2MP:00053858.3KIT, KITLG, ANPEP, MPO, VIM
3MP:00053877.6C5AR1, KIT, KITLG, ANPEP, MPO, VIM

Publications for Mast-Cell Sarcoma

Sources:
51PubMed
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Articles related to Mast-Cell Sarcoma:

(show all 29)
idTitleAuthorsYear
1
Pediatric mast cell sarcoma of temporal bone with novel L799F (2395 C>T) KIT mutation, mimicking histiocytic neoplasm. (23388130)
2013
2
Mast cell sarcoma mimicking metastatic colon carcinoma. (24141335)
2013
3
Mast cell sarcoma in an infant: a case report and review of the literature. (23211696)
2013
4
Mast cell sarcoma: a rare and potentially under-recognized diagnostic entity with specific therapeutic implications. (23196796)
2013
5
Mast cell sarcoma: a rare and aggressive entity--report of two cases and review of the literature. (23129735)
2013
6
Mast cell sarcoma with megakaryocytic differentiation in a calf. (22813945)
2012
7
Malignant transformation of mastocytoma developed on skin mastocytosis into cutaneous mast cell sarcoma. (22498828)
2012
8
Mast cell sarcoma of the scalp: the first sign of undisclosed systemic mastocytosis? (22963840)
2012
9
Successful treatment of mast cell sarcoma of the uterus with imatinib. (22020400)
2011
10
Mast cell sarcoma of the small intestine: a case report. (21778298)
2011
11
Mast-cell sarcoma of the tibia. (17405977)
2007
12
Aggressive systemic mastocytosis with sarcoma-like growth in the skeleton, leukemic progression, and partial loss of mast cell differentiation antigens. (18055976)
2007
13
Assessment of cyclooxygenase-2 expression in canine hemangiosarcoma, histiocytic sarcoma, and mast cell tumor. (15872381)
2005
14
Mast cells in cellular leiomyoma and endometrial stromal sarcoma of the uterus]. (15196440)
2004
15
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. (12801524)
2003
16
Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma. (12826896)
2003
17
Temporary response of localized intracranial mast cell sarcoma to combination chemotherapy. (11216707)
2001
18
Mast cell "densities" in vascular proliferations: a preliminary study of pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma. (10535252)
1999
19
Mast cell sarcoma with tissue eosinophilia arising in the ascending colon. (10430280)
1999
20
Association of bone marrow mastocytosis with extremely immature extramedullary mast cell sarcoma]. (9273545)
1997
21
What is your diagnosis? Mast cell sarcoma. (9097238)
1997
22
Brief communication, Histopathology of a spontaneously developing mast cell sarcoma in a Wistar rat. (8736393)
1996
23
Use of hyperthermia and radiotherapy in treatment of a large mast cell sarcoma in a dog. (3145930)
1988
24
Mast cell sarcoma of the larynx. (3088063)
1986
25
Mast cell sarcoma of the larynx in a dog: a case report. (104092)
1979
26
Chemotherapy in reticulum-cell sarcoma in five dogs and a cat and in mast-cell leukemia in a cat. (4936153)
1971
27
Multiple genital neoplasia (mast cell sarcoma, seminoma, and sertoli cell tumor) in a dog. (13306668)
1956
28
Preliminary observations on the use of cortisone in canine mast cell sarcoma. (13108793)
1953
29
Neoplastic diseases of dogs; mast cell sarcoma, lymphosarcoma, histiocytoma. (18118928)
1948

Genetic Variations for Mast-Cell Sarcoma

Expression for genes affiliated with Mast-Cell Sarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mast-Cell Sarcoma

Search GEO for disease gene expression data for Mast-Cell Sarcoma.

Pathways for genes affiliated with Mast-Cell Sarcoma

Sources:
52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 4Cell Signaling Technology, 30KEGG
See all sources

Pathways related to Mast-Cell Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7KIT, KITLG
29.7KITLG, KIT
39.6KIT, ANPEP
49.3KIT, KITLG, MPO
59.2KIT, KITLG, ANPEP
68.8KIT, KITLG, ANPEP, MPO

Compounds for genes affiliated with Mast-Cell Sarcoma

Sources:
45Novoseek, 50PharmGKB, 24HMDB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Mast-Cell Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.4ANPEP
2naphthol as-d chloroacetate4510.2MPO, KIT
3ag-12964510.1KIT, KITLG
4su54164510.1KITLG, KIT
5alpha-naphthyl butyrate4510.0MPO, ANPEP
6rhodamine 12345 5011.0KITLG, KIT
7carnosine45 2410.9MPO, VIM
8sodium azide459.9VIM, MPO
9heparin45 29 11 2412.9C5AR1, MPO
10prostaglandin459.8KITLG, VIM
11calcipotriol45 60 29 1112.8MPO, VIM
12creatinine459.8KITLG, C5AR1
13reticulin459.8ANPEP, VIM
14aspartate459.7C5AR1, ANPEP
15budesonide45 50 1111.7KITLG, MPO
16imatinib45 50 1111.6KIT, KITLG, FIP1L1
17citrulline45 2410.6MPO, VIM
18polyethylene glycol459.6MPO, ANPEP, KITLG
195fluorouracil459.5KIT, KITLG, MPO
20valine459.5VIM, MPO, KIT
21fluorochrome459.5KIT, ANPEP, VIM
22agarose459.5KITLG, KIT, C5AR1
23prednisolone45 29 1111.5MPO, KITLG, C5AR1
24dmso459.5KITLG, MPO, VIM
25methotrexate45 50 1111.4VIM, KITLG, KIT
26hydrocortisone45 2 60 1112.4KITLG, ANPEP, VIM
27cytochalasin b459.4VIM, MPO, C5AR1
28anaphylatoxin459.4MPO, C5AR1
29serine459.4C5AR1, ANPEP, MPO
30cytarabine45 50 1111.3KIT, KITLG, MPO, VIM
31fmlp459.3VIM, MPO, C5AR1
32formaldehyde45 2410.1VIM, MPO, ANPEP, KIT
33rantes459.1C5AR1, KITLG, ANPEP
34doxorubicin45 50 1111.1VIM, ANPEP, KITLG, KIT
35actinomycin d459.1KIT, KITLG, ANPEP, VIM
36superoxide45 249.9C5AR1, KITLG, ANPEP, MPO
37nitric oxide45 11 2410.9MPO, KITLG, KIT, C5AR1
38h2o2458.9C5AR1, KITLG, MPO, VIM
39wortmannin458.8C5AR1, KITLG, ANPEP, VIM
40methionine458.8KIT, ANPEP, VIM
41monochloroacetic acid458.8KIT, KITLG, ANPEP, MPO, VIM
42paraffin458.7VIM, MPO, ANPEP, KITLG, KIT
43lactate458.7VIM, MPO, ANPEP, KITLG, KIT
44oligonucleotide458.7C5AR1, KIT, ANPEP, VIM
45retinoic acid45 249.7VIM, MPO, ANPEP, KITLG, KIT
46histamine45 29 2410.7VIM, MPO, KITLG, KIT, C5AR1
47vegf458.6VIM, MPO, KITLG, KIT, C5AR1
48toluidine458.5VIM, ANPEP, KITLG, KIT, C5AR1
49alanine458.5VIM, ANPEP, KITLG, C5AR1
50tyrosine458.2C5AR1, KIT, KITLG, FIP1L1, ANPEP

GO Terms for genes affiliated with Mast-Cell Sarcoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Mast-Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryonic hemopoiesisGO:0351629.7KIT, KITLG
2germ cell programmed cell deathGO:0352349.4KIT, KITLG

Products for genes affiliated with Mast-Cell Sarcoma

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Sources for Mast-Cell Sarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet