MCID: MST001
MIFTS: 32

Mast-Cell Sarcoma malady

Blood diseases, Cancer diseases, Rare diseases categories

Summaries for Mast-Cell Sarcoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Mast cell sarcoma is an extremely aggressive form of sarcoma made up of neoplastic mast cells. A sarcoma... more...

MalaCards: Mast-Cell Sarcoma, also known as mast cell sarcoma, is related to leukemia and eosinophilia, and has symptoms including mastocytosis, bone marrow/medullar infiltration and lymphadenopathy/polyadenopathies. An important gene associated with Mast-Cell Sarcoma is FIP1L1 (factor interacting with PAPOLA and CPSF1). Affiliated tissues include skin, bone and bone marrow.

Aliases & Classifications for Mast-Cell Sarcoma

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9Disease Ontology, 11DISEASES, 63UMLS, 50Orphanet, 59SNOMED-CT, 28ICD9CM, 36MeSH, 41NCIt, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

50
mast cell sarcoma:
Age of onset: Variable


Aliases & Descriptions:

mast-cell sarcoma 9 11 63
mast cell sarcoma 50


External Ids:

Disease Ontology9 DOID:355
ICD9CM28 202.6
MeSH36 D012515
NCIt41 C9348
MESH via Orphanet37 D012515
ICD10 via Orphanet27 C96.2
SNOMED-CT via Orphanet60 118615008, 13583002, 188660004
UMLS via Orphanet64 C0036221

Related Diseases for Mast-Cell Sarcoma

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18GeneCards, 19GeneDecks
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Diseases related to Mast-Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.2FIP1L1, MPO
2eosinophilia30.1FIP1L1, MPO
3sarcoma10.8
4mastocytosis10.4
5lymphosarcoma10.1
6sertoli cell tumor10.1
7histiocytoma10.1
8seminoma10.1
9systemic mastocytosis10.1

Graphical network of diseases related to Mast-Cell Sarcoma:



Diseases related to mast-cell sarcoma

Symptoms for Mast-Cell Sarcoma

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50Orphanet
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Symptoms:

50 (show all 10)
  • mastocytosis
  • bone marrow/medullar infiltration
  • lymphadenopathy/polyadenopathies
  • mediastinal/hilar adenopathies
  • sarcoma
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness
  • splenomegaly
  • hepatomegaly/liver enlargement (excluding storage disease)
  • early death/lethality

Drugs & Therapeutics for Mast-Cell Sarcoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mast-Cell Sarcoma

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Anatomical Context for Mast-Cell Sarcoma

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34MalaCards
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MalaCards organs/tissues related to Mast-Cell Sarcoma:

34
Skin, Bone, Bone marrow, Liver, Colon, Small intestine, Uterus

Animal Models for Mast-Cell Sarcoma or affiliated genes

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Publications for Mast-Cell Sarcoma

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53PubMed
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Articles related to Mast-Cell Sarcoma:

(show all 24)
idTitleAuthorsYear
1
Pediatric mast cell sarcoma of temporal bone with novel L799F (2395 C>T) KIT mutation, mimicking histiocytic neoplasm. (23388130)
2013
2
Mast cell sarcoma mimicking metastatic colon carcinoma. (24141335)
2013
3
Mast cell sarcoma in an infant: a case report and review of the literature. (23211696)
2013
4
Mast cell sarcoma: a rare and potentially under-recognized diagnostic entity with specific therapeutic implications. (23196796)
2013
5
Mast cell sarcoma: a rare and aggressive entity--report of two cases and review of the literature. (23129735)
2013
6
Mast cell sarcoma with megakaryocytic differentiation in a calf. (22813945)
2012
7
Malignant transformation of mastocytoma developed on skin mastocytosis into cutaneous mast cell sarcoma. (22498828)
2012
8
Mast cell sarcoma of the scalp: the first sign of undisclosed systemic mastocytosis? (22963840)
2012
9
Successful treatment of mast cell sarcoma of the uterus with imatinib. (22020400)
2011
10
Mast cell sarcoma of the small intestine: a case report. (21778298)
2011
11
Mast-cell sarcoma of the tibia. (17405977)
2007
12
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. (12801524)
2003
13
Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma. (12826896)
2003
14
Temporary response of localized intracranial mast cell sarcoma to combination chemotherapy. (11216707)
2001
15
Mast cell sarcoma with tissue eosinophilia arising in the ascending colon. (10430280)
1999
16
Association of bone marrow mastocytosis with extremely immature extramedullary mast cell sarcoma]. (9273545)
1997
17
What is your diagnosis? Mast cell sarcoma. (9097238)
1997
18
Brief communication, Histopathology of a spontaneously developing mast cell sarcoma in a Wistar rat. (8736393)
1996
19
Use of hyperthermia and radiotherapy in treatment of a large mast cell sarcoma in a dog. (3145930)
1988
20
Mast cell sarcoma of the larynx. (3088063)
1986
21
Mast cell sarcoma of the larynx in a dog: a case report. (104092)
1979
22
Multiple genital neoplasia (mast cell sarcoma, seminoma, and sertoli cell tumor) in a dog. (13306668)
1956
23
Preliminary observations on the use of cortisone in canine mast cell sarcoma. (13108793)
1953
24
Neoplastic diseases of dogs; mast cell sarcoma, lymphosarcoma, histiocytoma. (18118928)
1948

Variations for Mast-Cell Sarcoma

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Expression for genes affiliated with Mast-Cell Sarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mast-Cell Sarcoma

Search GEO for disease gene expression data for Mast-Cell Sarcoma.

Pathways for genes affiliated with Mast-Cell Sarcoma

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Compounds for genes affiliated with Mast-Cell Sarcoma

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GO Terms for genes affiliated with Mast-Cell Sarcoma

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Products for genes affiliated with Mast-Cell Sarcoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Mast-Cell Sarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet