MCID: MST001
MIFTS: 49

Mast-Cell Sarcoma malady

Blood diseases, Cancer diseases categories

Summaries for Mast-Cell Sarcoma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Mast cell sarcoma is an extremely aggressive form of sarcoma made up of neoplastic mast cells. A sarcoma... more...

MalaCards: Mast-Cell Sarcoma, also known as mast cell sarcoma, is related to sarcoma and sertoli cell tumor, and has symptoms including early death/lethality, asthenia/fatigue/weakness and weight loss/loss of appetite/break in weight curve/general health alteration. An important gene associated with Mast-Cell Sarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Melanocyte Development and Pigmentation and Regulation of KIT signaling. The compounds cycloheximide and naphthol as-d chloroacetate have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related mouse phenotypes are reproductive system and cardiovascular system.

Aliases & Classifications for Mast-Cell Sarcoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 48Orphanet, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
mast cell sarcoma:
Age of onset: Variable


Aliases & Descriptions:

mast-cell sarcoma 8 10 60
mast cell sarcoma 48


External Ids:

Disease Ontology8 DOID:355
MeSH34 D012515
NCIt39 C9348
ICD9CM27 202.6
MESH via Orphanet35 D012515
ICD10 via Orphanet26 C96.2
SNOMED-CT via Orphanet57 118615008, 13583002, 188660004
UMLS via Orphanet61 C0036221

Related Diseases for Mast-Cell Sarcoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mast-Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.1VIM, ANPEP, KITLG, KIT
2sertoli cell tumor30.1VIM
3systemic mastocytosis30.1KITLG, KIT
4seminoma30.1KIT, KITLG
5mast cell neoplasm30.1KITLG, KIT
6mast-cell leukemia30.1KIT, KITLG, MPO
7eosinophilia30.1C5AR1, FIP1L1, MPO
8leukemia30.1MPO, ANPEP, FIP1L1, KITLG, KIT, C5AR1
9colon sarcoma10.3
10larynx sarcoma10.3
11lymphosarcoma10.1
12small cell sarcoma10.1
13cutaneous mastocytosis10.1
14histiocytoma10.1
15skin sarcoma10.1
16small intestinal sarcoma10.1
17indolent systemic mastocytosis10.0ISM1
18urticaria10.0C5AR1
19meningioma10.0VIM
20hepatitis10.0ANPEP
21angiosarcoma10.0VIM
22adult respiratory distress syndrome10.0C5AR1
23germinoma10.0KIT
24uterine carcinosarcoma10.0KIT
25perineurioma10.0VIM
26thymus cancer10.0KIT
27atopy10.0MPO
28inflammatory bowel disease10.0MPO
29polycythemia10.0KITLG
30malignant mesothelioma10.0VIM
31hepatocellular carcinoma10.0ANPEP
32allergic rhinitis10.0MPO
33vitiligo10.0KITLG
34stomach cancer10.0ANPEP
35encephalomyelitis10.0ANPEP, C5AR1
36pleurisy10.0MPO
37myelofibrosis10.0FIP1L1
38colorectal cancer10.0KITLG
39peritonitis10.0MPO, C5AR1
40glomerulonephritis10.0C5AR1, MPO
41rheumatoid arthritis10.0C5AR1, MPO
42intestinal disease10.0C5AR1, MPO
43leukostasis10.0MPO, C5AR1
44fibrosarcoma10.0ANPEP, VIM
45acute undifferentiated leukemia10.0MPO, ANPEP
46phyllode tumor10.0VIM, KIT
47endometrial stromal sarcoma10.0KIT, VIM
48malignant mixed mullerian tumor10.0KIT, VIM
49multiple sclerosis10.0KITLG, ANPEP
50adenoma10.0KITLG, ANPEP

Graphical network of the top 20 diseases related to Mast-Cell Sarcoma:



Diseases related to mast-cell sarcoma

Clinical Features for Mast-Cell Sarcoma

About this section
Sources:
48Orphanet
See all sources


Symptoms:

48 (show all 10)
  • early death/lethality
  • asthenia/fatigue/weakness
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • bone marrow/medullar infiltration
  • lymphadenopathy/polyadenopathies
  • mediastinal/hilar adenopathies
  • splenomegaly
  • hepatomegaly/liver enlargement (excluding storage disease)
  • mastocytosis
  • sarcoma

Drugs & Therapeutics for Mast-Cell Sarcoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Mast-Cell Sarcoma

Drug clinical trials:

Search ClinicalTrials for Mast-Cell Sarcoma

Search NIH Clinical Center for Mast-Cell Sarcoma

Search CenterWatch for Mast-Cell Sarcoma

Genetic Tests for Mast-Cell Sarcoma

About this section

Anatomical Context for Mast-Cell Sarcoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Mast-Cell Sarcoma:

32
Skin, Bone, Bone marrow, Liver, Uterus, Colon, Small intestine

Animal Models for Mast-Cell Sarcoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Mast-Cell Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.2ANPEP, KITLG
2MP:00053858.3KIT, KITLG, ANPEP, MPO, VIM
3MP:00053877.6C5AR1, KIT, KITLG, ANPEP, MPO, VIM

Publications for Mast-Cell Sarcoma

About this section
Sources:
50PubMed
See all sources

Articles related to Mast-Cell Sarcoma:

(show all 29)
idTitleAuthorsYear
1
Pediatric mast cell sarcoma of temporal bone with novel L799F (2395 C>T) KIT mutation, mimicking histiocytic neoplasm. (23388130)
2013
2
Mast cell sarcoma mimicking metastatic colon carcinoma. (24141335)
2013
3
Mast cell sarcoma in an infant: a case report and review of the literature. (23211696)
2013
4
Mast cell sarcoma: a rare and potentially under-recognized diagnostic entity with specific therapeutic implications. (23196796)
2013
5
Mast cell sarcoma: a rare and aggressive entity--report of two cases and review of the literature. (23129735)
2013
6
Mast cell sarcoma with megakaryocytic differentiation in a calf. (22813945)
2012
7
Malignant transformation of mastocytoma developed on skin mastocytosis into cutaneous mast cell sarcoma. (22498828)
2012
8
Mast cell sarcoma of the scalp: the first sign of undisclosed systemic mastocytosis? (22963840)
2012
9
Successful treatment of mast cell sarcoma of the uterus with imatinib. (22020400)
2011
10
Mast cell sarcoma of the small intestine: a case report. (21778298)
2011
11
Mast-cell sarcoma of the tibia. (17405977)
2007
12
Aggressive systemic mastocytosis with sarcoma-like growth in the skeleton, leukemic progression, and partial loss of mast cell differentiation antigens. (18055976)
2007
13
Assessment of cyclooxygenase-2 expression in canine hemangiosarcoma, histiocytic sarcoma, and mast cell tumor. (15872381)
2005
14
Mast cells in cellular leiomyoma and endometrial stromal sarcoma of the uterus]. (15196440)
2004
15
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. (12801524)
2003
16
Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma. (12826896)
2003
17
Temporary response of localized intracranial mast cell sarcoma to combination chemotherapy. (11216707)
2001
18
Mast cell "densities" in vascular proliferations: a preliminary study of pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma. (10535252)
1999
19
Mast cell sarcoma with tissue eosinophilia arising in the ascending colon. (10430280)
1999
20
Association of bone marrow mastocytosis with extremely immature extramedullary mast cell sarcoma]. (9273545)
1997
21
What is your diagnosis? Mast cell sarcoma. (9097238)
1997
22
Brief communication, Histopathology of a spontaneously developing mast cell sarcoma in a Wistar rat. (8736393)
1996
23
Use of hyperthermia and radiotherapy in treatment of a large mast cell sarcoma in a dog. (3145930)
1988
24
Mast cell sarcoma of the larynx. (3088063)
1986
25
Mast cell sarcoma of the larynx in a dog: a case report. (104092)
1979
26
Chemotherapy in reticulum-cell sarcoma in five dogs and a cat and in mast-cell leukemia in a cat. (4936153)
1971
27
Multiple genital neoplasia (mast cell sarcoma, seminoma, and sertoli cell tumor) in a dog. (13306668)
1956
28
Preliminary observations on the use of cortisone in canine mast cell sarcoma. (13108793)
1953
29
Neoplastic diseases of dogs; mast cell sarcoma, lymphosarcoma, histiocytoma. (18118928)
1948

Genetic Variations for Mast-Cell Sarcoma

About this section

Expression for genes affiliated with Mast-Cell Sarcoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mast-Cell Sarcoma

Search GEO for disease gene expression data for Mast-Cell Sarcoma.

Pathways for genes affiliated with Mast-Cell Sarcoma

About this section
Sources:
51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 4Cell Signaling Technology, 29KEGG
See all sources

Pathways related to Mast-Cell Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7KIT, KITLG
29.7KITLG, KIT
39.6KIT, ANPEP
49.3KIT, KITLG, MPO
59.2KIT, KITLG, ANPEP
68.8KIT, KITLG, ANPEP, MPO

Compounds for genes affiliated with Mast-Cell Sarcoma

About this section
Sources:
44Novoseek, 49PharmGKB, 24HMDB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Mast-Cell Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.4ANPEP
2naphthol as-d chloroacetate4410.2KIT, MPO
3ag-12964410.1KIT, KITLG
4su54164410.1KIT, KITLG
5alpha-naphthyl butyrate4410.0ANPEP, MPO
6rhodamine 12344 4911.0KIT, KITLG
7carnosine44 2410.9VIM, MPO
8sodium azide449.9MPO, VIM
9heparin44 28 11 2412.9C5AR1, MPO
10prostaglandin449.8KITLG, VIM
11calcipotriol44 59 28 1112.8MPO, VIM
12creatinine449.8C5AR1, KITLG
13reticulin449.8ANPEP, VIM
14aspartate449.7ANPEP, C5AR1
15budesonide44 49 1111.7MPO, KITLG
16imatinib44 49 1111.6KIT, KITLG, FIP1L1
17citrulline44 2410.6MPO, VIM
18polyethylene glycol449.6MPO, ANPEP, KITLG
195fluorouracil449.5KITLG, MPO, KIT
20valine449.5MPO, VIM, KIT
21fluorochrome449.5VIM, ANPEP, KIT
22agarose449.5C5AR1, KIT, KITLG
23prednisolone44 28 1111.5MPO, KITLG, C5AR1
24dmso449.5KITLG, VIM, MPO
25methotrexate44 49 1111.4KITLG, KIT, VIM
26hydrocortisone44 2 59 1112.4KITLG, ANPEP, VIM
27cytochalasin b449.4C5AR1, MPO, VIM
28anaphylatoxin449.4C5AR1, MPO
29serine449.4MPO, ANPEP, C5AR1
30cytarabine44 49 1111.3KIT, VIM, MPO, KITLG
31fmlp449.3VIM, MPO, C5AR1
32formaldehyde44 2410.1ANPEP, KIT, MPO, VIM
33rantes449.1ANPEP, C5AR1, KITLG
34doxorubicin44 49 1111.1ANPEP, VIM, KIT, KITLG
35actinomycin d449.1ANPEP, KITLG, VIM, KIT
36superoxide44 249.9KITLG, C5AR1, MPO, ANPEP
37nitric oxide44 11 2410.9C5AR1, KITLG, MPO, KIT
38h2o2448.9MPO, KITLG, C5AR1, VIM
39wortmannin448.8C5AR1, VIM, ANPEP, KITLG
40methionine448.8KIT, VIM, ANPEP
41monochloroacetic acid448.8VIM, MPO, ANPEP, KITLG, KIT
42paraffin448.7MPO, VIM, KIT, KITLG, ANPEP
43lactate448.7MPO, KIT, KITLG, VIM, ANPEP
44oligonucleotide448.7VIM, ANPEP, C5AR1, KIT
45retinoic acid44 249.7KIT, MPO, KITLG, VIM, ANPEP
46histamine44 28 2410.7C5AR1, KIT, KITLG, MPO, VIM
47vegf448.6KIT, KITLG, VIM, MPO, C5AR1
48toluidine448.5ANPEP, VIM, C5AR1, KITLG, KIT
49alanine448.5C5AR1, KITLG, ANPEP, VIM
50tyrosine448.2KITLG, C5AR1, ANPEP, FIP1L1, KIT

GO Terms for genes affiliated with Mast-Cell Sarcoma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Mast-Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryonic hemopoiesisGO:0351629.7KIT, KITLG
2germ cell programmed cell deathGO:0352349.4KIT, KITLG

Products for genes affiliated with Mast-Cell Sarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mast-Cell Sarcoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet