MCID: MST001
MIFTS: 40

Mast-Cell Sarcoma malady

Categories: Blood diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Mast-Cell Sarcoma

Aliases & Descriptions for Mast-Cell Sarcoma:

Name: Mast-Cell Sarcoma 12 42 14 69
Mast Cell Sarcoma 56

Characteristics:

Orphanet epidemiological data:

56
mast cell sarcoma
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:355
ICD10 33 C96.2
ICD9CM 35 202.6
MeSH 42 D012515
NCIt 47 C9348
Orphanet 56 ORPHA66661
ICD10 via Orphanet 34 C96.2
MESH via Orphanet 43 D012515
UMLS via Orphanet 70 C0036221
UMLS 69 C0036221

Summaries for Mast-Cell Sarcoma

MalaCards based summary : Mast-Cell Sarcoma, also known as mast cell sarcoma, is related to sarcoma and uremic neuropathy, and has symptoms including fatigue, splenomegaly and hepatomegaly. An important gene associated with Mast-Cell Sarcoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic cell lineage. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and colon, and related phenotype is Increased shRNA abundance (Z-score > 2).

Wikipedia : 71 Mast cell sarcoma is an extremely aggressive form of sarcoma made up of neoplastic mast cells. A sarcoma... more...

Related Diseases for Mast-Cell Sarcoma

Diseases related to Mast-Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Related Disease Score Top Affiliating Genes
1 sarcoma 10.4
2 uremic neuropathy 10.2 KIT KITLG
3 hemangioma of peripheral nerve 10.1 KIT KITLG
4 high grade b-cell lymphoma with rearrangements of myc and bcl2 and/or bcl6 10.1 KIT KITLG
5 cough variant asthma 10.1 KIT KITLG
6 kidney rhabdoid cancer 10.1 KIT KITLG
7 adducted thumbs dundar type 10.1 KIT MPO
8 priapism 10.1 KIT KITLG
9 congenital disorder of glycosylation, type iq 10.1 KIT MPO
10 neurofibromatosis 10.1 KIT MPO
11 extranodal nasal nk/t cell lymphoma 10.1 KIT KITLG
12 epidermolysis bullosa simplex, recessive 1 10.1 KIT KITLG
13 may-thurner syndrome 10.1 KIT KITLG
14 marfanoid hypermobility syndrome 10.1 KIT VIM
15 syndromic x-linked intellectual disability 10.1 KIT KITLG
16 liver angiosarcoma 10.1 KIT VIM
17 uterine hypoplasia 10.1 KIT VIM
18 acute perichondritis of pinna 10.1 KIT MPO
19 alcohol-induced mental disorder 10.1 KIT VIM
20 pericoronitis 10.1 KIT KITLG
21 sebaceous adenoma 10.1 KIT VIM
22 stomach diverticulosis 10.1 KIT VIM
23 mesenchymoma 10.1 KIT VIM
24 dentinogenesis imperfecta, shields type ii 10.1 KIT KITLG
25 pilar sheath acanthoma 10.1 KIT VIM
26 enchondromatosis dwarfism deafness 10.1 KIT VIM
27 vulvar angiokeratoma 10.1 KITLG VIM
28 fitz-hugh-curtis syndrome 10.1 KIT VIM
29 diarrhea, chronic, with villous atrophy 10.1 KIT VIM
30 popliteal pterygium syndrome, bartsocas-papas type 10.1 KIT VIM
31 prostate cancer, hereditary, x-linked 1 10.1 KIT KITLG
32 lipoadenoma 10.1 KIT VIM
33 desmoid tumor 10.0 MPO VIM
34 ganglioneuroma 10.0 FIP1L1 KIT
35 kahrizi syndrome 10.0 FIP1L1 KIT
36 c-p angle neurinoma 10.0 KIT VIM
37 mastocytosis 10.0
38 ovarian papillary neoplasm 10.0 MPO VIM
39 human granulocytic anaplasmosis 10.0 KIT VIM
40 hyperandrogenism due to cortisone reductase deficiency 10.0 FIP1L1 KIT
41 cecum adenoma 10.0 KIT VIM
42 adenosarcoma 10.0 KIT VIM
43 occlusion precerebral artery 10.0 KIT VIM
44 amyloidosis, hereditary, transthyretin-related 10.0 KIT VIM
45 actinobacillosis 10.0 KIT KITLG MPO
46 extraosseous ewing's sarcoma 9.9 KIT VIM
47 hyperphosphatasia with mental retardation syndrome 2 9.9 KITLG MPO
48 gastrointestinal stromal tumor 9.9 KIT KITLG VIM
49 kala-azar 1 9.9 KIT KITLG VIM
50 thrombophilia due to activated protein c resistance 9.9 FIP1L1 VIM

Graphical network of the top 20 diseases related to Mast-Cell Sarcoma:



Diseases related to Mast-Cell Sarcoma

Symptoms & Phenotypes for Mast-Cell Sarcoma

Human phenotypes related to Mast-Cell Sarcoma:

56 32 (show all 9)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 56 32 Frequent (79-30%) HP:0012378
2 splenomegaly 56 32 Frequent (79-30%) HP:0001744
3 hepatomegaly 56 32 Frequent (79-30%) HP:0002240
4 weight loss 56 32 Frequent (79-30%) HP:0001824
5 hypoplasia of the ear cartilage 56 32 Frequent (79-30%) HP:0100720
6 sarcoma 56 32 Very frequent (99-80%) HP:0100242
7 mediastinal lymphadenopathy 56 32 Frequent (79-30%) HP:0100721
8 mastocytosis 56 32 Very frequent (99-80%) HP:0100495
9 lymphadenopathy 56 Frequent (79-30%)

GenomeRNAi Phenotypes related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.72 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.72 VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.72 MPO
4 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.72 VIM
5 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.72 MPO
6 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.72 VIM KITLG MPO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.72 VIM
8 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.72 MPO
9 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.72 VIM
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.72 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.72 KITLG
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.72 VIM MPO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.72 VIM
14 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.72 MPO
15 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.72 KITLG
16 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.72 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.72 VIM
18 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.72 MPO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.72 MPO
20 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.72 KITLG
21 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.72 VIM
22 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.72 KITLG

Drugs & Therapeutics for Mast-Cell Sarcoma

Drugs for Mast-Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
3 Anti-Allergic Agents Phase 3
4 Antipruritics Phase 3
5 Dermatologic Agents Phase 3
6 Gastrointestinal Agents Phase 3
7 Histamine Antagonists Phase 3
8 Histamine H1 Antagonists Phase 3
9
Histamine Phosphate Phase 3 51-74-1 65513
10 Neurotransmitter Agents Phase 3
11
Serotonin Phase 3 50-67-9 5202
12 Serotonin Agents Phase 3
13 Serotonin Antagonists Phase 3
14 Imatinib Mesylate Phase 2 123596
15 Protein Kinase Inhibitors Phase 2
16 Cola Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
2 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2
3 Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (advSM) and Relapsed or Refractory Myeloid Malignancies Recruiting NCT02561988 Phase 1
4 Study of Information Received About Fertility and Infertility in Patients Who Have Finished Treatment for Cancer Unknown status NCT01295463
5 Evaluation of Patient Satisfaction With and Acceptance of Their Totally-implanted Central Venous Catheter Terminated NCT01616537
6 Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection Withdrawn NCT00378781

Search NIH Clinical Center for Mast-Cell Sarcoma

Cochrane evidence based reviews: mast-cell sarcoma

Genetic Tests for Mast-Cell Sarcoma

Anatomical Context for Mast-Cell Sarcoma

MalaCards organs/tissues related to Mast-Cell Sarcoma:

39
Skin, Bone, Colon, Bone Marrow, Small Intestine, Uterus

Publications for Mast-Cell Sarcoma

Articles related to Mast-Cell Sarcoma:

(show all 27)
id Title Authors Year
1
Mast cell sarcoma: new cases and literature review. ( 27602777 )
2016
2
Anaplastic mast cell sarcoma: a unique pathologic entity in mastocytosis. ( 27808598 )
2016
3
Mast cell sarcoma: clinical management. ( 24745684 )
2014
4
Mast cell sarcoma mimicking metastatic colon carcinoma. ( 24141335 )
2013
5
Mast cell sarcoma: a rare and potentially under-recognized diagnostic entity with specific therapeutic implications. ( 23196796 )
2013
6
Mast cell sarcoma in an infant: a case report and review of the literature. ( 23211696 )
2013
7
Mast cell sarcoma: a rare and aggressive entity--report of two cases and review of the literature. ( 23129735 )
2013
8
Pediatric mast cell sarcoma of temporal bone with novel L799F (2395 C>T) KIT mutation, mimicking histiocytic neoplasm. ( 23388130 )
2013
9
Mast cell sarcoma with megakaryocytic differentiation in a calf. ( 22813945 )
2012
10
Mast cell sarcoma of the scalp: the first sign of undisclosed systemic mastocytosis? ( 22963840 )
2012
11
Malignant transformation of mastocytoma developed on skin mastocytosis into cutaneous mast cell sarcoma. ( 22498828 )
2012
12
Mast cell sarcoma of the small intestine: a case report. ( 21778298 )
2011
13
Successful treatment of mast cell sarcoma of the uterus with imatinib. ( 22020400 )
2011
14
Mast-cell sarcoma of the tibia. ( 17405977 )
2007
15
Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma. ( 12826896 )
2003
16
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. ( 12801524 )
2003
17
Temporary response of localized intracranial mast cell sarcoma to combination chemotherapy. ( 11216707 )
2001
18
Mast cell sarcoma with tissue eosinophilia arising in the ascending colon. ( 10430280 )
1999
19
[Association of bone marrow mastocytosis with extremely immature extramedullary mast cell sarcoma]. ( 9273545 )
1997
20
What is your diagnosis? Mast cell sarcoma. ( 9097238 )
1997
21
Brief communication, Histopathology of a spontaneously developing mast cell sarcoma in a Wistar rat. ( 8736393 )
1996
22
Use of hyperthermia and radiotherapy in treatment of a large mast cell sarcoma in a dog. ( 3145930 )
1988
23
Mast cell sarcoma of the larynx. ( 3088063 )
1986
24
Mast cell sarcoma of the larynx in a dog: a case report. ( 104092 )
1979
25
Multiple genital neoplasia (mast cell sarcoma, seminoma, and sertoli cell tumor) in a dog. ( 13306668 )
1956
26
Preliminary observations on the use of cortisone in canine mast cell sarcoma. ( 13108793 )
1953
27
Neoplastic diseases of dogs; mast cell sarcoma, lymphosarcoma, histiocytoma. ( 18118928 )
1948

Variations for Mast-Cell Sarcoma

Expression for Mast-Cell Sarcoma

Search GEO for disease gene expression data for Mast-Cell Sarcoma.

Pathways for Mast-Cell Sarcoma

Pathways related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.93 KIT KITLG MPO
2 11.39 KIT KITLG
3 11.2 KIT KITLG MPO
4 11.05 KIT KITLG
5 10.93 KIT KITLG
6 10.69 KIT KITLG MPO
7 10.36 KIT KITLG

GO Terms for Mast-Cell Sarcoma

Biological processes related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-mediated signaling GO:0048015 9.43 KIT KITLG
2 male gonad development GO:0008584 9.4 KIT KITLG
3 phosphatidylinositol phosphorylation GO:0046854 9.37 KIT KITLG
4 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.32 KIT KITLG
5 positive regulation of MAP kinase activity GO:0043406 9.26 KIT KITLG
6 ovarian follicle development GO:0001541 9.16 KIT KITLG
7 embryonic hemopoiesis GO:0035162 8.96 KIT KITLG
8 ectopic germ cell programmed cell death GO:0035234 8.62 KIT KITLG

Molecular functions related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.96 KIT KITLG
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.62 KIT KITLG

Sources for Mast-Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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