MCID: MST001
MIFTS: 40

Mast-Cell Sarcoma malady

Categories: Blood diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Mast-Cell Sarcoma

About this section
Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 45NCIt, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Mast-Cell Sarcoma:

Name: Mast-Cell Sarcoma 11 39 13 68
 
Mast Cell Sarcoma 54

Characteristics:

Orphanet epidemiological data:

54
mast cell sarcoma:
Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:355
ICD1030 C96.2
ICD9CM32 202.6
MeSH39 D012515
NCIt45 C9348
Orphanet54 ORPHA66661
ICD10 via Orphanet31 C96.2
MESH via Orphanet40 D012515
UMLS via Orphanet69 C0036221

Summaries for Mast-Cell Sarcoma

About this section
Wikipedia:71 Mast cell sarcoma is an extremely aggressive form of sarcoma made up of neoplastic mast cells. A sarcoma... more...

MalaCards based summary: Mast-Cell Sarcoma, also known as mast cell sarcoma, is related to sarcoma and uremic neuropathy, and has symptoms including Array, Array and Array. An important gene associated with Mast-Cell Sarcoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways are Differentiation Pathway and Regulation of KIT signaling. Affiliated tissues include skin, colon and bone, and related mouse phenotype Increased shRNA abundance (Z-score > 2).

Related Diseases for Mast-Cell Sarcoma

About this section

Diseases related to Mast-Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma10.4
2uremic neuropathy10.2KIT, KITLG
3hemangioma of peripheral nerve10.1KIT, KITLG
4high grade b-cell lymphoma with rearrangements of myc and bcl2 and/or bcl610.1KIT, KITLG
5cough variant asthma10.1KIT, KITLG
6kidney rhabdoid cancer10.1KIT, KITLG
7adducted thumbs dundar type10.1KIT, MPO
8priapism10.1KIT, KITLG
9congenital disorder of glycosylation, type iq10.1KIT, MPO
10neurofibromatosis10.1KIT, MPO
11extranodal nasal nk/t cell lymphoma10.1KIT, KITLG
12epidermolysis bullosa simplex, recessive 110.1KIT, KITLG
13may-thurner syndrome10.1KIT, KITLG
14marfanoid hypermobility syndrome10.1KIT, VIM
15syndromic x-linked intellectual disability10.1KIT, KITLG
16liver angiosarcoma10.1KIT, VIM
17uterine hypoplasia10.1KIT, VIM
18acute perichondritis of pinna10.1KIT, MPO
19alcohol-induced mental disorder10.1KIT, VIM
20pericoronitis10.1KIT, KITLG
21sebaceous adenoma10.1KIT, VIM
22stomach diverticulosis10.1KIT, VIM
23mesenchymoma10.1KIT, VIM
24dentinogenesis imperfecta, shields type ii10.1KIT, KITLG
25pilar sheath acanthoma10.1KIT, VIM
26enchondromatosis dwarfism deafness10.1KIT, VIM
27vulvar angiokeratoma10.1KITLG, VIM
28fitz-hugh-curtis syndrome10.1KIT, VIM
29diarrhea, chronic, with villous atrophy10.1KIT, VIM
30popliteal pterygium syndrome, bartsocas-papas type10.1KIT, VIM
31prostate cancer, hereditary, x-linked 110.1KIT, KITLG
32lipoadenoma10.1KIT, VIM
33desmoid tumor10.0MPO, VIM
34ganglioneuroma10.0FIP1L1, KIT
35kahrizi syndrome10.0FIP1L1, KIT
36c-p angle neurinoma10.0KIT, VIM
37mastocytosis10.0
38ovarian papillary neoplasm10.0MPO, VIM
39human granulocytic anaplasmosis10.0KIT, VIM
40hyperandrogenism due to cortisone reductase deficiency10.0FIP1L1, KIT
41cecum adenoma10.0KIT, VIM
42adenosarcoma10.0KIT, VIM
43occlusion precerebral artery10.0KIT, VIM
44amyloidosis, hereditary, transthyretin-related10.0KIT, VIM
45actinobacillosis10.0KIT, KITLG, MPO
46extraosseous ewing's sarcoma9.9KIT, VIM
47hyperphosphatasia with mental retardation syndrome 29.9KITLG, MPO
48gastrointestinal stromal tumor9.9KIT, KITLG, VIM
49kala-azar 19.9KIT, KITLG, VIM
50thrombophilia due to activated protein c resistance9.9FIP1L1, VIM

Graphical network of the top 20 diseases related to Mast-Cell Sarcoma:



Diseases related to mast-cell sarcoma

Symptoms & Phenotypes for Mast-Cell Sarcoma

About this section

Human phenotypes related to Mast-Cell Sarcoma:

 54 64 (show all 9)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 splenomegaly64 54 Frequent (79-30%) HP:0001744
2 weight loss64 54 Frequent (79-30%) HP:0001824
3 hepatomegaly64 54 Frequent (79-30%) HP:0002240
4 lymphadenopathy54 Frequent (79-30%)
5 fatigue64 54 Frequent (79-30%) HP:0012378
6 sarcoma64 54 Very frequent (99-80%) HP:0100242
7 mastocytosis64 54 Very frequent (99-80%) HP:0100495
8 hypoplasia of the ear cartilage64 54 Frequent (79-30%) HP:0100720
9 mediastinal lymphadenopathy64 54 Frequent (79-30%) HP:0100721

GenomeRNAi Phenotypes related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1928.8KITLG, MPO, VIM

Drugs & Therapeutics for Mast-Cell Sarcoma

About this section

Drugs for Mast-Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Histamineapproved, investigationalPhase 3105075614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-(4-imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
4-imidazoleethylamine
5-Imidazoleethylamine
5-imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminoethylglyoxaline
beta-aminoethylimidazole
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
2
CyproheptadineapprovedPhase 320129-03-32913
Synonyms:
1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine
1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine
1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine
129-03-3
4-(5-Dibenzo(a,D)cyclohepten-5-ylidine)-1-methylpiperidine
4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine
4-(5H-Dibenzo(a,D)cyclohepten-5-ylidene)-1-methylpiperidine
4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene
4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine
4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine
4-Dibenzo[a,D]cyclohepten-5-ylidene-1-methyl-piperidine
41354-29-4
5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
5-20-08-00500 (Beilstein Handbook Reference)
AC1L1ER8
AKOS004119847
Axoprol
BIDD:GT0324
BPBio1_000096
BPBio1_000155
BRD-K28143534-001-01-4
BRD-K28143534-003-03-6
BRN 1685976
BSPBio_000086
Biomol-NT_000131
C06935
CAS-969-33-5
CCRIS 5232
CHEBI:4046
CHEMBL516
CID2913
CYPROHEPTADINE
Ciproheptadina
Ciproheptadina [INN-Spanish]
Ciprovit
Ciprovit (TN)
Cypoheptadine
Cyproheptadiene
Cyproheptadin
Cyproheptadine
 
Cyproheptadine (INN)
Cyproheptadine Hcl
Cyproheptadine [INN:BAN]
Cyproheptadinum
Cyproheptadinum [INN-Latin]
D07765
DB00434
Dibenzosuberonone/Cyproheptadine
Dihexazin
Dronactin
EINECS 204-928-9
Eiproheptadine
Glutodina
HMS2090P20
HSDB 3048
L001016
LS-114933
Lopac-C-6022
Lopac0_000246
MK 141
MolPort-002-507-777
NCGC00015252-01
NCGC00015252-02
NCGC00015252-03
NCGC00015252-09
NCGC00024293-02
NCGC00024293-04
NCGC00024293-05
Oprea1_498140
PDSP1_001229
PDSP2_001213
Periactin
Periactine
Periactinol
Prestwick0_000103
Prestwick1_000103
Prestwick2_000103
Prestwick3_000103
SPBio_002025
STK802098
Tocris-0996
UNII-2YHB6175DO
Viternum
nchembio.559-comp10
3Neurotransmitter AgentsPhase 318340
4
SerotoninPhase 3362750-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
5Serotonin AgentsPhase 33156
6Serotonin AntagonistsPhase 31409
7
Histamine PhosphatePhase 3104951-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
 
EINECS 200-118-4
H0147
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
LS-78569
UNII-QWB37T4WZZ
8Histamine H1 AntagonistsPhase 3791
9AntipruriticsPhase 3841
10Anti-Allergic AgentsPhase 31522
11Dermatologic AgentsPhase 35806
12Gastrointestinal AgentsPhase 38402
13Histamine AntagonistsPhase 3961
14Protein Kinase InhibitorsPhase 23689
15Imatinib MesylatePhase 2600123596
16ColaNutraceutical1946

Interventional clinical trials:

idNameStatusNCT IDPhase
1Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for CancerTerminatedNCT01132547Phase 3
2Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare DiseasesCompletedNCT00154388Phase 2
3Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (advSM) and Relapsed or Refractory Myeloid MalignanciesRecruitingNCT02561988Phase 1
4Study of Information Received About Fertility and Infertility in Patients Who Have Finished Treatment for CancerUnknown statusNCT01295463
5Evaluation of Patient Satisfaction With and Acceptance of Their Totally-implanted Central Venous CatheterTerminatedNCT01616537
6Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related InfectionWithdrawnNCT00378781

Search NIH Clinical Center for Mast-Cell Sarcoma


Cochrane evidence based reviews: mast-cell sarcoma

Genetic Tests for Mast-Cell Sarcoma

About this section

Anatomical Context for Mast-Cell Sarcoma

About this section

MalaCards organs/tissues related to Mast-Cell Sarcoma:

36
Skin, Colon, Bone, Uterus, Small intestine, Bone marrow

Publications for Mast-Cell Sarcoma

About this section

Articles related to Mast-Cell Sarcoma:

(show all 27)
idTitleAuthorsYear
1
Mast cell sarcoma: new cases and literature review. (27602777)
2016
2
Anaplastic mast cell sarcoma: a unique pathologic entity in mastocytosis. (27808598)
2016
3
Mast cell sarcoma: clinical management. (24745684)
2014
4
Mast cell sarcoma mimicking metastatic colon carcinoma. (24141335)
2013
5
Mast cell sarcoma: a rare and potentially under-recognized diagnostic entity with specific therapeutic implications. (23196796)
2013
6
Mast cell sarcoma in an infant: a case report and review of the literature. (23211696)
2013
7
Mast cell sarcoma: a rare and aggressive entity--report of two cases and review of the literature. (23129735)
2013
8
Pediatric mast cell sarcoma of temporal bone with novel L799F (2395 C>T) KIT mutation, mimicking histiocytic neoplasm. (23388130)
2013
9
Mast cell sarcoma with megakaryocytic differentiation in a calf. (22813945)
2012
10
Mast cell sarcoma of the scalp: the first sign of undisclosed systemic mastocytosis? (22963840)
2012
11
Malignant transformation of mastocytoma developed on skin mastocytosis into cutaneous mast cell sarcoma. (22498828)
2012
12
Mast cell sarcoma of the small intestine: a case report. (21778298)
2011
13
Successful treatment of mast cell sarcoma of the uterus with imatinib. (22020400)
2011
14
Mast-cell sarcoma of the tibia. (17405977)
2007
15
Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma. (12826896)
2003
16
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. (12801524)
2003
17
Temporary response of localized intracranial mast cell sarcoma to combination chemotherapy. (11216707)
2001
18
Mast cell sarcoma with tissue eosinophilia arising in the ascending colon. (10430280)
1999
19
Association of bone marrow mastocytosis with extremely immature extramedullary mast cell sarcoma]. (9273545)
1997
20
What is your diagnosis? Mast cell sarcoma. (9097238)
1997
21
Brief communication, Histopathology of a spontaneously developing mast cell sarcoma in a Wistar rat. (8736393)
1996
22
Use of hyperthermia and radiotherapy in treatment of a large mast cell sarcoma in a dog. (3145930)
1988
23
Mast cell sarcoma of the larynx. (3088063)
1986
24
Mast cell sarcoma of the larynx in a dog: a case report. (104092)
1979
25
Multiple genital neoplasia (mast cell sarcoma, seminoma, and sertoli cell tumor) in a dog. (13306668)
1956
26
Preliminary observations on the use of cortisone in canine mast cell sarcoma. (13108793)
1953
27
Neoplastic diseases of dogs; mast cell sarcoma, lymphosarcoma, histiocytoma. (18118928)
1948

Variations for Mast-Cell Sarcoma

About this section

Expression for genes affiliated with Mast-Cell Sarcoma

About this section
Search GEO for disease gene expression data for Mast-Cell Sarcoma.

Pathways for genes affiliated with Mast-Cell Sarcoma

About this section

GO Terms for genes affiliated with Mast-Cell Sarcoma

About this section

Biological processes related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1ectopic germ cell programmed cell deathGO:003523410.2KIT, KITLG
2embryonic hemopoiesisGO:003516210.2KIT, KITLG
3male gonad developmentGO:000858410.1KIT, KITLG
4ovarian follicle developmentGO:000154110.1KIT, KITLG
5phosphatidylinositol phosphorylationGO:004685410.1KIT, KITLG
6phosphatidylinositol-mediated signalingGO:004801510.1KIT, KITLG
7positive regulation of MAP kinase activityGO:004340610.0KIT, KITLG
8regulation of phosphatidylinositol 3-kinase signalingGO:00140669.5KIT, KITLG

Molecular functions related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.0KIT, KITLG
2Ras guanyl-nucleotide exchange factor activityGO:00050889.5KIT, KITLG

Sources for Mast-Cell Sarcoma

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet