MCID: MST005
MIFTS: 49

Mastitis malady

Reproductive diseases category
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Summaries for Mastitis

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Wikipedia:65 Mastitis is the inflammation of breast tissue.S. aureus is the most common etiological organism... more...

MalaCards based summary: Mastitis, also known as inflammatory disorder of breast, is related to systemic lupus erythematosus and tuberculosis. An important gene associated with Mastitis is HP (haptoglobin), and among its related pathways is amb2 Integrin signaling. The compounds probucol and deferoxamine have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and neutrophil.

Aliases & Classifications for Mastitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
See all sources

Mastitis, Aliases & Descriptions:

Name: Mastitis 8 10 44
Inflammatory Disorder of Breast 8 62
Inflammatory Disease of Breast 8 62
 
Inflammatory Breast Disease 8 62
Breast Inflammation Nos 8
Infectious Mastitis 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:10690
ICD9CM27 611.0
MeSH34 D008413
NCIt39 C53662
ICD1025 N61

Related Diseases for Mastitis

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Diseases related to Mastitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.1LTF, NOD2, VTN
2tuberculosis29.9LYZ, BPI, HP, NOD2
3arthritis29.3LYZ, VTN, HP, NOD2, LTF
4granulomatous mastitis11.0
5eosinophilic mastitis10.4
6breast cancer10.3
7pouchitis10.2LTF, NOD2
8ankylosing spondylitis10.2NOD2, HP
9membranous glomerulonephritis10.2VTN, HP
10inflammatory breast carcinoma10.2
11neonatal infective mastitis10.2
12pneumonia10.2
13periodontal disease10.2LTF, LYZ
14diabetic mastopathy10.2
15klebsiella10.2
16mycobacterium abscessus10.2
17mycobacterium fortuitum10.2
18primary sclerosing cholangitis10.2BPI, LTF
19nephrotic syndrome10.1HP, VTN
20hepatitis c10.1LTF, HP
21arthropathy10.1NOD2, BPI
22vasculitis10.1BPI, LTF
23hypersensitivity reaction type ii disease10.1LTF, LYZ
24proteinuria10.1HP, VTN
25toxic shock syndrome10.1
26breast lymphoma10.1
27prolactinoma10.1
28rhinotracheitis10.1
29calciphylaxis10.1
30lupus erythematosus10.1
31septic shock10.1LTF, BPI
32diabetic retinopathy10.1VTN, BPI
33primary hyperoxaluria10.0LYZ, HP
34reactive arthritis10.0LTF, HP, BPI
35crohn's disease10.0LTF, NOD2, LYZ
36cystic fibrosis10.0LTF, HP, BPI
37psoriasis10.0VTN, NOD2, LTF
38colitis10.0LTF, NOD2, BPI
39sarcoidosis10.0LYZ, VTN, NOD2
40ulcerative colitis10.0LTF, NOD2, BPI
41inflammatory bowel disease10.0LTF, NOD2, BPI
42atherosclerosis10.0NOD2, HP, VTN
43galactosemia9.9HP, VTN, BPI
44endometriosis9.9HP, VTN
45liver cirrhosis9.9LTF, VTN, BPI
46breast reconstruction9.9
47diabetes mellitus9.9
48hepatitis9.9
49hiv-19.9
50relapsing polychondritis9.9

Graphical network of the top 20 diseases related to Mastitis:



Diseases related to mastitis

Symptoms for Mastitis

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Drugs & Therapeutics for Mastitis

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Drug clinical trials:

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Search NIH Clinical Center for Mastitis

Genetic Tests for Mastitis

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Anatomical Context for Mastitis

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MalaCards organs/tissues related to Mastitis:

32
Breast, Testes, Neutrophil, Liver, Pituitary

Animal Models for Mastitis or affiliated genes

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Publications for Mastitis

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Articles related to Mastitis:

(show top 50)    (show all 724)
idTitleAuthorsYear
1
Pulsed-Field Gel Electrophoresis (PFGE): Application in Population Structure Studies of Bovine Mastitis-Causing Streptococci. (25399106)
2015
2
Molecular and bacteriological investigation of subclinical mastitis caused by Staphylococcus aureus and Streptococcus agalactiae in domestic bovids from Ismailia, Egypt. (25374070)
2014
3
Granulomatous mastitis: changing clinical and imaging features with image-guided biopsy correlation. (24962828)
2014
4
Effects of clinical mastitis on reproductive and milk performance of Holstein cows in Morocco. (25367278)
2014
5
Comparison of the effect of surgical and medical therapy for the treatment of idiopathic granulomatous mastitis. (25002895)
2014
6
Bilateral Eosinophilic Mastitis: An uncommon unheard entity. (25171213)
2014
7
Bovine mastitis: frontiers in immunogenetics. (25339959)
2014
8
Staphylococcus aureus from 152 cases of bovine, ovine and caprine mastitis investigated by Multiple-locus variable number of tandem repeat analysis (MLVA). (25315988)
2014
9
Predictive value of prepartum serum metabolites for incidence of clinical and subclinical mastitis in grazing primiparous Holstein cows. (23526122)
2013
10
Idiopathic granulomatous mastitis: an autoimmune disease? (24082849)
2013
11
Tubercular mastitis - a great masquerader. (23354799)
2013
12
Trematode infections in pregnant ewes can predispose to mastitis during the subsequent lactation period. (24331730)
2013
13
Evaluation of PCR electrospray-ionization mass spectrometry for rapid molecular diagnosis of bovine mastitis. (23587378)
2013
14
Efficiency of two commercial on-farm pasteurizers for inactivation of mastitis pathogens in milk intended for feeding. of calves. (23367666)
2013
15
Evaluation of therapeutic potential of nanosilver particles synthesised using aloin in experimental murine mastitis model. (24028805)
2013
16
Immunotherapy of mastitis. (23523288)
2013
17
Coagulase-negative staphylococci (CNS) as an aetiological factor of mastitis in cows. (24195283)
2013
18
Stem cell research: a novel boulevard towards improved bovine mastitis management. (23983615)
2013
19
Incidence of subclinical mastitis in Dutch dairy heifers in the first 100 days in lactation and associated risk factors. (22541474)
2012
20
The relationship between the variants of the bovine MBL2 gene and milk production traits, mastitis, serum MBL-C levels and complement activity. (22771198)
2012
21
Herd characteristics and cow-level factors associated with Prototheca mastitis on dairy farms in Ontario, Canada. (22884347)
2012
22
Biofilm production and presence of ica and bap genes in Staphylococcus aureus strains isolated from cows with mastitis in the eastern Poland. (22708349)
2012
23
Serum amyloid A isoforms in serum and milk from cows with Staphylococcus aureus subclinical mastitis. (22100192)
2012
24
Bovine mastitis: the diagnostic properties of a PCR-based assay to monitor the Staphylococcus aureus genotype B status of a herd, using bulk tank milk. (22720925)
2012
25
Granulomatous mastitis: is it an autoimmune disease? Diagnostic and therapeutic dilemmas. (22068681)
2012
26
In vitro antimicrobial activity of Combretum molle (Combretaceae) against Staphylococcus aureus and Streptococcus agalactiae isolated from crossbred dairy cows with clinical mastitis. (22207479)
2012
27
Milk microbiome signatures of subclinical mastitis-affected cattle analysed by shotgun sequencing. (22277077)
2012
28
Effects of Jin-Ying-Tang on Staphylococcus aureus-induced mastitis in rabbit. (22303901)
2012
29
Molecular cloning, promoter analysis, SNP detection of Clusterin gene and their associations with mastitis in Chinese Holstein cows. (21667239)
2012
30
Improved identification including MALDI-TOF mass spectrometry analysis of group D streptococci from bovine mastitis and subsequent molecular characterization of corresponding Enterococcus faecalis and Enterococcus faecium isolates. (22677481)
2012
31
Histone H3K14 and H4K8 hyperacetylation is associated with Escherichia coli-induced mastitis in mice. (22419123)
2012
32
Taurine attenuates Streptococcus uberis-induced mastitis in rats by increasing T regulatory cells. (21809074)
2012
33
Draft genome sequence of Corynebacterium bovis DSM 20582, which causes clinical mastitis in dairy cows. (22843578)
2012
34
Genotypic characterization and evaluation of an antibiotic resistance of Trueperella pyogenes (Arcanobacterium pyogenes) isolated from milk of dairy cows with clinical mastitis. (22868181)
2012
35
Phenotypic and genotypic characterization of Streptococcus uberis isolated from bovine subclinical mastitis in Argentinean dairy farms. (22430996)
2011
36
The effect of recurrent episodes of clinical mastitis caused by gram-positive and gram-negative bacteria and other organisms on mortality and culling in Holstein dairy cows. (21943738)
2011
37
Multiplex PCR assay for species identification of bovine mastitis pathogens. (21972842)
2011
38
Lupus mastitis in systemic lupus erythematosus: a rare condition requiring a minimally invasive diagnostic approach. (22230423)
2011
39
Prevalence and molecular mechanism of macrolide and lincosamide resistance in staphylococci isolated from subclinical bovine mastitis in Turkey. (21799300)
2011
40
A HACCP-based approach to mastitis control in dairy herds. Part 2: Implementation and evaluation. (21777494)
2011
41
Erythema nodosum associated with granulomatous mastitis: report of two cases. (19701754)
2010
42
Granulomatous mastitis: presentation, treatment and outcome in 43 patients. (20569938)
2010
43
Idiopathic granulomatous mastitis in Hispanic women - Indiana, 2006-2008. (19959984)
2009
44
Idiopathic granulomatous mastitis: a heterogeneous disease with variable clinical presentation. (17541683)
2007
45
Idiopathic granulomatous mastitis: a case successfully treated with a minimum dose of a steroid. (16124160)
2005
46
Delayed neutrophil apoptosis in bovine subclinical mastitis. (15545372)
2004
47
Phage conversion of exfoliative toxin A in Staphylococcus aureus isolated from cows with mastitis. (14516710)
2003
48
Occurrence of the blaZ gene in penicillin resistant Staphylococcus aureus isolated from bovine mastitis in Denmark. (10605145)
1999
49
Caprine mastitis due to aspergillosis and zygomycosis: a pathological and immunohistochemical study. (8920218)
1996
50
Isolation of Mycoplasma agalactiae var bovis and infectious bovine rhinotracheitis virus from an outbreak of mastitis in France. (4375340)
1974

Variations for Mastitis

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Expression for genes affiliated with Mastitis

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Expression patterns in normal tissues for genes affiliated with Mastitis

Search GEO for disease gene expression data for Mastitis.

Pathways for genes affiliated with Mastitis

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Pathways related to Mastitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6HP, VTN

Compounds for genes affiliated with Mastitis

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Compounds related to Mastitis according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1probucol44 1111.1HP, LTF
2deferoxamine44 1111.1HP, LTF
3lactulose4410.0LTF, NOD2
4rifampicin44 28 6112.0LTF, HP
5lactose44 1111.0LTF, HP
6ribavirin44 50 1112.0LTF, HP
7pentoxifylline44 1111.0HP, LTF
8sodium chlorate4410.0LTF, VTN
9vitamin b124410.0LTF, HP
10pmma4410.0LTF, VTN
11fucoidan449.9LTF, VTN
12neopterin449.9LTF, HP
13cytochalasin b449.9LTF, VTN
14dextran sulfate449.9LTF, VTN
15n-formylmethionyl-leucylphenylalanine449.9VTN, LTF
16tetrapeptide449.9VTN, LTF
17kininogen449.9VTN, HP
18polymyxin b449.8LTF, BPI
19chloroquine44 2 50 28 1113.8VTN, HP
20anti-fungal449.8LTF, BPI
21polyethylene glycol449.8HP, VTN
22chondroitin sulfate44 2410.8VTN, LTF
23latex449.7VTN, LTF
24sodium dodecylsulfate449.7HP, VTN
25citrate449.7LTF, HP
26sialic acid449.6VTN, HP, LTF
27hyaluronic acid44 2410.6VTN, HP, LTF
28nacl449.6LYZ, HP, LTF
29fibrinogen449.6VTN, HP, LTF
30pge2449.5LTF, HP, VTN
31aspartate449.5LTF, HP, VTN
32actinomycin d449.5LTF, HP, BPI
33cytochalasin d44 6110.4LTF, VTN
34urea44 24 1111.4HP, VTN, BPI
35creatinine449.4LTF, HP, BPI
36lactate449.3BPI, VTN, HP
37carbohydrates449.3FUT2, HP, LTF
38dexamethasone44 50 28 1112.2LTF, HP, VTN
39cholesterol44 28 24 1112.1HP, VTN, BPI
40endotoxin449.1LTF, NOD2, HP, BPI
41nitric oxide44 24 1111.0BPI, HP, NOD2
42polysaccharide449.0BPI, VTN, HP, LTF
43heparin44 28 24 1112.0BPI, VTN, HP, LTF
44vegf449.0LTF, HP, VTN, BPI
45alanine449.0LTF, HP, VTN, BPI
46cysteine448.9LTF, HP, VTN, BPI
47glutamate448.9LTF, HP, VTN
48serine448.5LTF, NOD2, HP, VTN, BPI

GO Terms for genes affiliated with Mastitis

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Cellular components related to Mastitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.6HP, VTN
2extracellular spaceGO:0056158.5LTF, VTN, LYZ, HP
3extracellular regionGO:0055768.3LTF, LYZ, VTN, HP
4extracellular vesicular exosomeGO:0700627.2LTF, VTN, HP, BPI, LYZ, FUT2

Biological processes related to Mastitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1innate immune response in mucosaGO:0022279.8LTF, NOD2
2defense responseGO:0069529.6NOD2, HP
3positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.6LTF, NOD2
4retina homeostasisGO:0018959.6LYZ, LTF
5negative regulation of tumor necrosis factor productionGO:0327209.5NOD2, BPI
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4NOD2, VTN
7positive regulation of NF-kappaB transcription factor activityGO:0510929.3LTF, NOD2
8defense response to bacteriumGO:0427428.7NOD2, HP, BPI, LYZ

Molecular functions related to Mastitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.5LTF, VTN

Products for genes affiliated with Mastitis

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Sources for Mastitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet