MCID: MST005
MIFTS: 49

Mastitis malady

Reproductive diseases category
Download this MalaCard

Summaries for Mastitis

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Mastitis is the inflammation of breast tissue.S. aureus is the most common etiological organism... more...

MalaCards: Mastitis, also known as inflammatory disorder of breast, is related to tuberculosis and systemic lupus erythematosus. An important gene associated with Mastitis is HP (haptoglobin), and among its related pathways is amb2 Integrin signaling. The compounds probucol and deferoxamine have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and liver.

Aliases & Classifications for Mastitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

mastitis 8 10 45
inflammatory disorder of breast 8
inflammatory breast disease nos 8
inflammatory disease of breast 8
inflammatory breast disease 8
breast inflammation nos 8
infectious mastitis 62
mastitis nos 8


External Ids:

Disease Ontology8 DOID:10690
MeSH35 D008413
NCIt40 C53662
ICD9CM27 611.0
ICD1025 N61

Related Diseases for Mastitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mastitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.1LYZ, BPI, HP, NOD2
2systemic lupus erythematosus30.1LTF, NOD2, VTN
3arthritis30.0LYZ, VTN, HP, NOD2, LTF
4granulomatous mastitis11.0
5breast cancer10.3
6inflammatory breast carcinoma10.2
7neonatal infective mastitis10.2
8pneumonia10.1
9diabetic mastopathy10.1
10eosinophilic mastitis10.1
11klebsiella10.1
12mycobacterium abscessus10.1
13mycobacterium fortuitum10.1
14rhinotracheitis10.1
15breast lymphoma10.1
16calciphylaxis10.1
17toxic shock syndrome10.1
18lupus erythematosus10.1
19pouchitis10.1LTF, NOD2
20ankylosing spondylitis10.1NOD2, HP
21membranous glomerulonephritis10.1VTN, HP
22periodontal disease10.0LTF, LYZ
23primary sclerosing cholangitis10.0BPI, LTF
24nephrotic syndrome10.0HP, VTN
25hepatitis c10.0LTF, HP
26arthropathy10.0NOD2, BPI
27vasculitis10.0BPI, LTF
28hypersensitivity reaction type ii disease10.0LTF, LYZ
29proteinuria10.0HP, VTN
30septic shock10.0LTF, BPI
31diabetic retinopathy10.0VTN, BPI
32primary hyperoxaluria10.0LYZ, HP
33reactive arthritis10.0LTF, HP, BPI
34crohn's disease10.0LTF, NOD2, LYZ
35cystic fibrosis10.0LTF, HP, BPI
36psoriasis10.0VTN, NOD2, LTF
37sarcoidosis10.0LYZ, VTN, NOD2
38ulcerative colitis10.0LTF, NOD2, BPI
39inflammatory bowel disease10.0LTF, NOD2, BPI
40atherosclerosis10.0NOD2, HP, VTN
41galactosemia10.0HP, VTN, BPI
42endometriosis10.0HP, VTN
43liver cirrhosis10.0LTF, VTN, BPI
44chronic kidney failure9.9BPI, VTN, HP, LTF
45sepsis9.9LTF, NOD2, VTN, BPI
46breast reconstruction9.9
47relapsing polychondritis9.9
48ductal carcinoma in situ9.9
49leukocyte adhesion deficiency9.9
50hidradenitis suppurativa9.9

Graphical network of the top 20 diseases related to Mastitis:



Diseases related to mastitis

Symptoms for Mastitis

About this section

Drugs & Therapeutics for Mastitis

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Mastitis

Search NIH Clinical Center for Mastitis

Genetic Tests for Mastitis

About this section

Anatomical Context for Mastitis

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Mastitis:

33
Breast, Testes, Liver, Pituitary

Animal Models for Mastitis or affiliated genes

About this section

Publications for Mastitis

About this section
Sources:
52PubMed
See all sources

Articles related to Mastitis:

(show top 50)    (show all 686)
idTitleAuthorsYear
1
Molecular epidemiology of recurrent clinical mastitis due to Streptococcus uberis: Evidence of both an environmental source and recurring infection with the same strain. (24239086)
2014
2
Predictive value of prepartum serum metabolites for incidence of clinical and subclinical mastitis in grazing primiparous Holstein cows. (23526122)
2013
3
Idiopathic granulomatous mastitis: an autoimmune disease? (24082849)
2013
4
Tubercular mastitis - a great masquerader. (23354799)
2013
5
Trematode infections in pregnant ewes can predispose to mastitis during the subsequent lactation period. (24331730)
2013
6
Evaluation of PCR electrospray-ionization mass spectrometry for rapid molecular diagnosis of bovine mastitis. (23587378)
2013
7
Efficiency of two commercial on-farm pasteurizers for inactivation of mastitis pathogens in milk intended for feeding. of calves. (23367666)
2013
8
Evaluation of therapeutic potential of nanosilver particles synthesised using aloin in experimental murine mastitis model. (24028805)
2013
9
Immunotherapy of mastitis. (23523288)
2013
10
Coagulase-negative staphylococci (CNS) as an aetiological factor of mastitis in cows. (24195283)
2013
11
Stem cell research: a novel boulevard towards improved bovine mastitis management. (23983615)
2013
12
Goat mammary gland expression of Cecropin B to inhibit bacterial pathogens causing mastitis. (23394371)
2013
13
Sensitivity and specificity of a hand-held milk electrical conductivity meter compared to the California mastitis test for mastitis in dairy cattle. (22981736)
2013
14
Nitric oxide concentrations in mammary quarters during heifer mastitis. (23079198)
2013
15
Short communication: antimicrobial susceptibility and frequency of resistance genes in Escherichia coli isolated from bovine mastitis. (23498019)
2013
16
Incidence of subclinical mastitis in Dutch dairy heifers in the first 100 days in lactation and associated risk factors. (22541474)
2012
17
The relationship between the variants of the bovine MBL2 gene and milk production traits, mastitis, serum MBL-C levels and complement activity. (22771198)
2012
18
Herd characteristics and cow-level factors associated with Prototheca mastitis on dairy farms in Ontario, Canada. (22884347)
2012
19
Biofilm production and presence of ica and bap genes in Staphylococcus aureus strains isolated from cows with mastitis in the eastern Poland. (22708349)
2012
20
Serum amyloid A isoforms in serum and milk from cows with Staphylococcus aureus subclinical mastitis. (22100192)
2012
21
Bovine mastitis: the diagnostic properties of a PCR-based assay to monitor the Staphylococcus aureus genotype B status of a herd, using bulk tank milk. (22720925)
2012
22
Granulomatous mastitis: is it an autoimmune disease? Diagnostic and therapeutic dilemmas. (22068681)
2012
23
In vitro antimicrobial activity of Combretum molle (Combretaceae) against Staphylococcus aureus and Streptococcus agalactiae isolated from crossbred dairy cows with clinical mastitis. (22207479)
2012
24
Milk microbiome signatures of subclinical mastitis-affected cattle analysed by shotgun sequencing. (22277077)
2012
25
Effects of Jin-Ying-Tang on Staphylococcus aureus-induced mastitis in rabbit. (22303901)
2012
26
Molecular cloning, promoter analysis, SNP detection of Clusterin gene and their associations with mastitis in Chinese Holstein cows. (21667239)
2012
27
Improved identification including MALDI-TOF mass spectrometry analysis of group D streptococci from bovine mastitis and subsequent molecular characterization of corresponding Enterococcus faecalis and Enterococcus faecium isolates. (22677481)
2012
28
Histone H3K14 and H4K8 hyperacetylation is associated with Escherichia coli-induced mastitis in mice. (22419123)
2012
29
Taurine attenuates Streptococcus uberis-induced mastitis in rats by increasing T regulatory cells. (21809074)
2012
30
Draft genome sequence of Corynebacterium bovis DSM 20582, which causes clinical mastitis in dairy cows. (22843578)
2012
31
Genotypic characterization and evaluation of an antibiotic resistance of Trueperella pyogenes (Arcanobacterium pyogenes) isolated from milk of dairy cows with clinical mastitis. (22868181)
2012
32
Phenotypic and genotypic characterization of Streptococcus uberis isolated from bovine subclinical mastitis in Argentinean dairy farms. (22430996)
2011
33
The effect of recurrent episodes of clinical mastitis caused by gram-positive and gram-negative bacteria and other organisms on mortality and culling in Holstein dairy cows. (21943738)
2011
34
Multiplex PCR assay for species identification of bovine mastitis pathogens. (21972842)
2011
35
Lupus mastitis in systemic lupus erythematosus: a rare condition requiring a minimally invasive diagnostic approach. (22230423)
2011
36
Prevalence and molecular mechanism of macrolide and lincosamide resistance in staphylococci isolated from subclinical bovine mastitis in Turkey. (21799300)
2011
37
A HACCP-based approach to mastitis control in dairy herds. Part 2: Implementation and evaluation. (21777494)
2011
38
Relationship between somatic cell count status and subsequent clinical mastitis in Dutch dairy cows. (21885136)
2011
39
Erythema nodosum associated with granulomatous mastitis: report of two cases. (19701754)
2010
40
Granulomatous mastitis: presentation, treatment and outcome in 43 patients. (20569938)
2010
41
Idiopathic granulomatous mastitis in Hispanic women - Indiana, 2006-2008. (19959984)
2009
42
Idiopathic granulomatous mastitis: a heterogeneous disease with variable clinical presentation. (17541683)
2007
43
Idiopathic granulomatous mastitis: a case successfully treated with a minimum dose of a steroid. (16124160)
2005
44
Delayed neutrophil apoptosis in bovine subclinical mastitis. (15545372)
2004
45
Phage conversion of exfoliative toxin A in Staphylococcus aureus isolated from cows with mastitis. (14516710)
2003
46
A clinicopathological review of 34 cases of inflammatory breast disease showing an association between corynebacteria infection and granulomatous mastitis. (12745457)
2003
47
Occurrence of the blaZ gene in penicillin resistant Staphylococcus aureus isolated from bovine mastitis in Denmark. (10605145)
1999
48
Caprine mastitis due to aspergillosis and zygomycosis: a pathological and immunohistochemical study. (8920218)
1996
49
Idiopathic granulomatous mastitis. Report of a case clinically and mammographically simulating breast carcinoma. (7936770)
1994
50
Isolation of Mycoplasma agalactiae var bovis and infectious bovine rhinotracheitis virus from an outbreak of mastitis in France. (4375340)
1974

Variations for Mastitis

About this section

Expression for genes affiliated with Mastitis

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mastitis

Search GEO for disease gene expression data for Mastitis.

Pathways for genes affiliated with Mastitis

About this section
Sources:
50PathCards, 38NCBI BioSystems Database
See all sources

Pathways related to Mastitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6HP, VTN

Compounds for genes affiliated with Mastitis

About this section
Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 3BitterDB, 24HMDB
See all sources

Compounds related to Mastitis according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1probucol45 1111.1HP, LTF
2deferoxamine45 1111.1HP, LTF
3lactulose4510.0LTF, NOD2
4rifampicin45 29 6112.0LTF, HP
5lactose45 1111.0LTF, HP
6ribavirin45 51 1112.0LTF, HP
7pentoxifylline45 1111.0HP, LTF
8sodium chlorate4510.0LTF, VTN
9vitamin b124510.0LTF, HP
10pmma4510.0LTF, VTN
11fucoidan459.9LTF, VTN
12neopterin459.9LTF, HP
13cytochalasin b459.9LTF, VTN
14dextran sulfate459.9LTF, VTN
15n-formylmethionyl-leucylphenylalanine459.9VTN, LTF
16tetrapeptide459.9VTN, LTF
17kininogen459.9VTN, HP
18polymyxin b459.8LTF, BPI
19chloroquine45 3 51 29 1113.8VTN, HP
20anti-fungal459.8LTF, BPI
21polyethylene glycol459.8HP, VTN
22chondroitin sulfate45 2410.8VTN, LTF
23latex459.7VTN, LTF
24sodium dodecylsulfate459.7HP, VTN
25citrate459.7LTF, HP
26sialic acid459.6VTN, HP, LTF
27hyaluronic acid45 2410.6VTN, HP, LTF
28nacl459.6LYZ, HP, LTF
29fibrinogen459.6VTN, HP, LTF
30pge2459.5LTF, HP, VTN
31aspartate459.5LTF, HP, VTN
32actinomycin d459.5LTF, HP, BPI
33cytochalasin d45 6110.4LTF, VTN
34urea45 24 1111.4HP, VTN, BPI
35creatinine459.4LTF, HP, BPI
36lactate459.3BPI, VTN, HP
37carbohydrates459.3FUT2, HP, LTF
38dexamethasone45 51 29 1112.2LTF, HP, VTN
39cholesterol45 29 24 1112.1HP, VTN, BPI
40endotoxin459.1LTF, NOD2, HP, BPI
41nitric oxide45 24 1111.0BPI, HP, NOD2
42polysaccharide459.0BPI, VTN, HP, LTF
43heparin45 29 24 1112.0BPI, VTN, HP, LTF
44vegf459.0LTF, HP, VTN, BPI
45alanine459.0LTF, HP, VTN, BPI
46cysteine458.9LTF, HP, VTN, BPI
47glutamate458.9LTF, HP, VTN
48serine458.5LTF, NOD2, HP, VTN, BPI

GO Terms for genes affiliated with Mastitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Mastitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.6HP, VTN
2extracellular spaceGO:0056158.5LYZ, VTN, HP, LTF
3extracellular regionGO:0055768.3LTF, HP, VTN, LYZ
4extracellular vesicular exosomeGO:0700627.2LTF, HP, VTN, BPI, LYZ, FUT2

Biological processes related to Mastitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1innate immune response in mucosaGO:0022279.8LTF, NOD2
2defense responseGO:0069529.6NOD2, HP
3positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.6LTF, NOD2
4retina homeostasisGO:0018959.6LYZ, LTF
5negative regulation of tumor necrosis factor productionGO:0327209.5NOD2, BPI
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4NOD2, VTN
7positive regulation of NF-kappaB transcription factor activityGO:0510929.3LTF, NOD2
8defense response to bacteriumGO:0427428.7NOD2, HP, BPI, LYZ

Molecular functions related to Mastitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.5LTF, VTN

Products for genes affiliated with Mastitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mastitis

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet