MCID: MST005
MIFTS: 49

Mastitis malady

Reproductive diseases category

Summaries for Mastitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Mastitis is the inflammation of breast tissue.S. aureus is the most common etiological organism... more...

MalaCards: Mastitis, also known as inflammatory disorder of breast, is related to pneumonia and toxic shock syndrome. An important gene associated with Mastitis is HP (haptoglobin), and among its related pathways are Selenium Pathway and Selenium Metabolism and Selenoproteins. The compounds exorphins and cmpa have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and liver.

Aliases & Classifications for Mastitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

mastitis 8 10 44
inflammatory disorder of breast 8
inflammatory breast disease nos 8
inflammatory disease of breast 8
inflammatory breast disease 8
breast inflammation nos 8
infectious mastitis 60
mastitis nos 8


External Ids:

Disease Ontology8 DOID:10690
MeSH34 D008413
NCIt39 C53662
ICD9CM27 611.0
ICD1025 N61

Related Diseases for Mastitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mastitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.2VTN, LACTB
2toxic shock syndrome30.0SELM, SELK, SELO, LACTB
3systemic lupus erythematosus30.0VTN, NOD2, LTF, CSN1S1
4arthritis30.0VTN, LACTB, NOD2, CXCL6, HP, LTF
5peritonitis29.8LACTB
6diabetes mellitus29.8VTN, GPX5, HP, CSN1S1
7breast cancer10.3
8granulomatous mastitis10.3
9neonatal infective mastitis10.2
10inflammatory breast carcinoma10.2
11tuberculosis10.1
12rhinotracheitis10.0
13calciphylaxis10.0
14breast lymphoma10.0
15breast disease10.0
16lupus erythematosus10.0
17protein-energy malnutrition10.0CSN1S1
18dysentery10.0LTF, LACTB
19periodontal disease10.0LTF
20staphyloenterotoxemia10.0SELO, SELK, SELM
21lactose intolerance10.0LTF, CSN1S1
22liver cirrhosis10.0VTN, LACTB, LTF, CSN1S1
23sepsis10.0LTF, CXCL6, NOD2, LACTB, VTN
24dental caries10.0CSN1S1, LPO, LTF
25cystic fibrosis10.0LPO, LTF, HP, LACTB
26perinatal necrotizing enterocolitis10.0LTF
27chronic kidney failure10.0VTN, LACTB, HP, LTF
28celiac disease10.0LALBA, CSN1S1
29asthma10.0VTN, NOD2, CXCL6, LPO, CSN1S1
30adenocarcinoma10.0CSN1S1, VTN
31reactive arthritis10.0LTF, HP
32glomerulonephritis10.0VTN, CSN1S1
33atopic dermatitis10.0LALBA, NOD2, CSN1S1
34membranous glomerulonephritis10.0HP, VTN
35crohn's disease10.0NOD2, LTF
36breast reconstruction9.9
37prolactinoma9.9
38ductal carcinoma in situ9.9
39relapsing polychondritis9.9
40male breast cancer9.9
41granulomatous dermatitis9.9
42cat-scratch disease9.9
43hepatitis e9.9
44hyperprolactinemia9.9
45sweat gland carcinoma9.9
46wegener's granulomatosis9.9
47pasteurellosis9.9
48leukocyte adhesion deficiency9.9
49hidradenitis suppurativa9.9
50breast apocrine carcinoma9.9

Graphical network of the top 20 diseases related to Mastitis:



Diseases related to mastitis

Clinical Features for Mastitis

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Drugs & Therapeutics for Mastitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Mastitis

Search NIH Clinical Center for Mastitis

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Genetic Tests for Mastitis

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Anatomical Context for Mastitis

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32MalaCards
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MalaCards organs/tissues related to Mastitis:

32
Breast, Testes, Liver, Pituitary

Animal Models for Mastitis or affiliated genes

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Publications for Mastitis

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Sources:
50PubMed
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Articles related to Mastitis:

(show top 50)    (show all 692)
idTitleAuthorsYear
1
Immunotherapy of mastitis. (23523288)
2013
2
Goat mammary gland expression of Cecropin B to inhibit bacterial pathogens causing mastitis. (23394371)
2013
3
Genetic parameters for natural antibodies and associations with specific antibody and mastitis in Canadian Holsteins. (23587396)
2013
4
Antibiotics for mastitis in breastfeeding women. (23450563)
2013
5
Puerperal mastitis: a reproductive event of importance affecting anti-mucin antibody levels and ovarian cancer risk. (23925696)
2013
6
A genome-wide association study for somatic cell score using the Illumina high-density bovine beadchip identifies several novel QTL potentially related to mastitis susceptibility. (24223582)
2013
7
Escherichia coli- and Staphylococcus aureus-induced mastitis differentially modulate transcriptional responses in neighbouring uninfected bovine mammary gland quarters. (23324411)
2013
8
Amelioration of altered oxidant/antioxidant balance of Indian water buffaloes with subclinical mastitis by vitamins A, D3, E, and H supplementation. (23239221)
2013
9
The changing face of mastitis control. (24293439)
2013
10
Rate of transmission: a major determinant of the cost of clinical mastitis. (23958003)
2013
11
Should we manage all cases of granulomatous mastitis conservatively? A 14 year experience. (23458219)
2013
12
Chemical structures of the secondary cell wall polymers (SCWPs) isolated from bovine mastitis Streptococcus uberis. (23810981)
2013
13
Molecular characterization and clonal diversity of methicillin-susceptible Staphylococcus aureus in milk of cows with mastitis in Brazil. (24054305)
2013
14
Nordic veterinarians' threshold for medical treatment of dairy cows, influence on disease recording and medicine use: mild clinical mastitis as an example. (23948145)
2013
15
Bacterial community profiling of milk samples as a means to understand culture-negative bovine clinical mastitis. (23634219)
2013
16
Increased detection of mastitis pathogens by real-time PCR compared to bacterial culture. (23976784)
2013
17
Implementation of multivariate cumulative sum control charts in mastitis and lameness monitoring. (23849640)
2013
18
First outbreak of bovine mastitis caused by Prototheca blaschkeae. (23201242)
2013
19
Serum amyloid A isoforms in serum and milk from cows with Staphylococcus aureus subclinical mastitis. (22100192)
2012
20
Molecular cloning, promoter analysis, SNP detection of Clusterin gene and their associations with mastitis in Chinese Holstein cows. (21667239)
2012
21
Predictive ability of alternative models for genetic analysis of clinical mastitis. (22394234)
2012
22
Lipopolysaccharide pretreatment of the udder protects against experimental Escherichia coli mastitis. (21990573)
2012
23
Combined long-term steroid and immunosuppressive treatment regimen in granulomatous mastitis. (23904832)
2012
24
Effect of dietary copper source on response to coliform mastitis in dairy cows. (22281330)
2012
25
Mid-infrared prediction of lactoferrin content in bovine milk: potential indicator of mastitis. (22717388)
2012
26
Antimicrobial resistance profiles of common mastitis pathogens on Canadian dairy farms. (22818446)
2012
27
The exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis in dairy cattle. (22923050)
2012
28
Detection of stapylococcal enterotoxin, methicillin-resistant and Panton-Valentine leukocidin genes in coagulase-negative staphylococci isolated from cows and ewes with subclinical mastitis. (22160510)
2012
29
Two splice variants of the bovine lactoferrin gene identified in Staphylococcus aureus isolated from mastitis in dairy cattle. (22194176)
2011
30
Short communication: profile of virulence factors of Staphylococcus aureus isolated from subclinical bovine mastitis in the state of Rio de Janeiro, Brazil. (21700015)
2011
31
The ability of common mastitis-causing pathogens to survive an ensiling period. (21943753)
2011
32
Functional adaptations of the transcriptome to mastitis-causing pathogens: the mammary gland and beyond. (21968536)
2011
33
Randomized clinical trial to evaluate the efficacy of a 5-day ceftiofur hydrochloride intramammary treatment on nonsevere gram-negative clinical mastitis. (22118109)
2011
34
Identification and antibiogram of microbes associated with bovine mastitis. (21774624)
2011
35
The selective treatment of clinical mastitis based on on-farm culture results: II. Effects on lactation performance, including clinical mastitis recurrence, somatic cell count, milk production, and cow survival. (21854918)
2011
36
Cystic neutrophilic granulomatous mastitis: an underappreciated pattern strongly associated with gram-positive bacilli. (21846918)
2011
37
Experimentally induced mastitis and metritis modulate soy bean derived isoflavone biotransformation in diary cows. (21890188)
2011
38
Differentially expressed genes associated with Staphylococcus aureus mastitis of Canadian Holstein cows. (17658619)
2007
39
Dependence between acute phase response, oxidative status and mastitis of cows. (16780184)
2006
40
Granulomatous mastitis: a clinicopathological review of 26 cases. (15203730)
2004
41
Mammographic and sonographic findings in the diagnosis of idiopathic granulomatous mastitis. (11702165)
2001
42
Granulomatous mastitis: mammographic and sonographic appearances. (10430126)
1999
43
Production of enterotoxins and toxic shock syndrome toxin by Staphylococcus aureus isolated from bovine mastitis in Brazil. (10664976)
1999
44
Idiopathic granulomatous mastitis. Report of a case clinically and mammographically simulating breast carcinoma. (7936770)
1994
45
Granulomatous mastitis caused by histoplasma and mimicking inflammatory breast carcinoma. (2912873)
1989
46
Ultrastructure of Prototheca zopfii in bovine granulomatous mastitis. (6730224)
1984
47
Isolation of Mycoplasma agalactiae var bovis and infectious bovine rhinotracheitis virus from an outbreak of mastitis in France. (4375340)
1974
48
Infectious bovine rhinotracheitis virus recovered from the milk of a cow with mastitis. (4813530)
1974
49
Mycobacterium fortuitum as a cause of bovine mastitis: tuberculin sensitivity following experimental infections. (5884059)
1965
50
The similarity of estrogenic effect in premenstrual tension, menstrual anomalies, chronic cystic mastitis and cancer of the breast. (18869635)
1948

Genetic Variations for Mastitis

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Expression for genes affiliated with Mastitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mastitis

Search GEO for disease gene expression data for Mastitis.

Pathways for genes affiliated with Mastitis

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37NCBI BioSystems Database
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Pathways related to Mastitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3SELM, SELK, SELO
210.3SELM, SELK, SELO

Compounds for genes affiliated with Mastitis

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Mastitis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1exorphins4410.8CSN1S1, LTF
2cmpa4410.8CSN1S1, LALBA
3thiocyanate44 2411.8LPO, LTF, TST
4cyanide44 2411.8TST, HP, LPO
5lactose44 1111.8LALBA, HP, LTF, CSN1S1
6polyacrylic acid4410.8CSN1S1, VTN
7rifampicin44 28 5912.8LACTB, HP, LTF
8polyethylene glycol4410.8CSN1S1, HP, LALBA, VTN
9aspartate4410.8NDUFAB1, CSN1S1, LTF, VTN
10sodium dodecylsulfate4410.8VTN, LALBA, HP, CSN1S1
11whey4410.8LALBA, LTF, LPO, CSN1S1
12kininogen4410.7CSN1S1, HP, VTN
13urea44 11 2412.7CSN1S1, HP, LALBA, VTN
14sialic acid4410.7VTN, HP, LTF, LPO
15carbohydrates4410.7LALBA, HP, LTF, CSN1S1
16vitamin b124410.7CSN1S1, LTF, HP
17polysaccharide4410.7VTN, LALBA, HP, LTF, CSN1S1
18nacl4410.7CSN1S1, LTF, HP, LALBA
19fibrinogen4410.7CSN1S1, LTF, HP, LALBA, VTN
20selenium44 2411.7SELM, SELK, GPX5, LPO
21hypothiocyanite44 2411.7LTF, LPO
22lactulose4410.7LTF, NOD2
23ovomucoid4410.7CSN1S1, LALBA
24succinate4410.7LTF, CSN1S1, NDUFAB1
25polyacrylamide4410.7LALBA, HP, LTF, CSN1S1
26sodium chlorate4410.7LTF, VTN
27iron44 2411.7NDUFAB1, LPO, LTF, HP, LALBA, TST
28lactate4410.7NDUFAB1, CSN1S1, LPO, HP, VTN
29phenolphthalein44 1111.7LPO, LTF
30heparin44 28 11 2413.7CSN1S1, LTF, HP, LALBA, VTN
31ascorbic acid44 2411.6HP, LTF, LPO, CSN1S1
32alanine4410.6VTN, LALBA, HP, LTF, CSN1S1, NDUFAB1
33aprotinin44 1111.6LALBA, LTF, CSN1S1
34trichloroacetic acid4410.6LALBA, CSN1S1
35ampicillin44 1111.6LTF, LACTB
36methionine4410.5CSN1S1, LPO, HP, LALBA
37amoxicillin44 49 1112.5LACTB, LTF
38cysteine4410.4CSN1S1, LPO, LTF, HP, LALBA, VTN
39gliadin4410.4LALBA, CSN1S1
40mannitol44 1111.4LALBA, NOD2, CSN1S1
41serine4410.3CSN1S1, LTF, HP, CXCL6, NOD2, LACTB
42ofloxacin44 2 1112.3LTF, LACTB
43metronidazole44 1111.1LTF, LACTB

GO Terms for genes affiliated with Mastitis

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16Gene Ontology
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Biological processes related to Mastitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to oxidative stressGO:00697910.3SELK, GPX5, LPO
2defense response to bacteriumGO:04274210.1LALBA, NOD2, HP, LTF

Molecular functions related to Mastitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00820110.4VTN, CXCL6, LTF

Products for genes affiliated with Mastitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mastitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet