MCID: MST005
MIFTS: 49

Mastitis malady

Reproductive diseases category

Summaries for Mastitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Mastitis is the inflammation of breast tissue.S. aureus is the most common etiological organism... more...

MalaCards: Mastitis, also known as inflammatory disorder of breast, is related to pneumonia and toxic shock syndrome. An important gene associated with Mastitis is HP (haptoglobin), and among its related pathways are Selenium Pathway and Selenium Metabolism and Selenoproteins. The compounds exorphins and cmpa have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and liver.

Aliases & Classifications for Mastitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

mastitis 8 10 44
inflammatory disorder of breast 8
inflammatory breast disease nos 8
inflammatory disease of breast 8
inflammatory breast disease 8
breast inflammation nos 8
infectious mastitis 60
mastitis nos 8


External Ids:

Disease Ontology8 DOID:10690
MeSH34 D008413
NCIt39 C53662
ICD9CM27 611.0
ICD1025 N61

Related Diseases for Mastitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mastitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.2VTN, LACTB
2toxic shock syndrome30.0SELM, SELK, SELO, LACTB
3systemic lupus erythematosus30.0VTN, NOD2, LTF, CSN1S1
4arthritis30.0VTN, LACTB, NOD2, CXCL6, HP, LTF
5peritonitis29.8LACTB
6diabetes mellitus29.8VTN, GPX5, HP, CSN1S1
7breast cancer10.3
8granulomatous mastitis10.3
9neonatal infective mastitis10.2
10inflammatory breast carcinoma10.2
11tuberculosis10.1
12rhinotracheitis10.0
13calciphylaxis10.0
14breast lymphoma10.0
15breast disease10.0
16lupus erythematosus10.0
17protein-energy malnutrition10.0CSN1S1
18dysentery10.0LTF, LACTB
19periodontal disease10.0LTF
20staphyloenterotoxemia10.0SELO, SELK, SELM
21lactose intolerance10.0LTF, CSN1S1
22liver cirrhosis10.0VTN, LACTB, LTF, CSN1S1
23sepsis10.0LTF, CXCL6, NOD2, LACTB, VTN
24dental caries10.0CSN1S1, LPO, LTF
25cystic fibrosis10.0LPO, LTF, HP, LACTB
26perinatal necrotizing enterocolitis10.0LTF
27chronic kidney failure10.0VTN, LACTB, HP, LTF
28celiac disease10.0LALBA, CSN1S1
29asthma10.0VTN, NOD2, CXCL6, LPO, CSN1S1
30adenocarcinoma10.0CSN1S1, VTN
31reactive arthritis10.0LTF, HP
32glomerulonephritis10.0VTN, CSN1S1
33atopic dermatitis10.0LALBA, NOD2, CSN1S1
34membranous glomerulonephritis10.0HP, VTN
35crohn's disease10.0NOD2, LTF
36breast reconstruction9.9
37prolactinoma9.9
38ductal carcinoma in situ9.9
39relapsing polychondritis9.9
40male breast cancer9.9
41granulomatous dermatitis9.9
42cat-scratch disease9.9
43hepatitis e9.9
44hyperprolactinemia9.9
45sweat gland carcinoma9.9
46wegener's granulomatosis9.9
47pasteurellosis9.9
48leukocyte adhesion deficiency9.9
49hidradenitis suppurativa9.9
50breast apocrine carcinoma9.9

Graphical network of the top 20 diseases related to Mastitis:



Diseases related to mastitis

Clinical Features for Mastitis

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Drugs & Therapeutics for Mastitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Mastitis

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Genetic Tests for Mastitis

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Anatomical Context for Mastitis

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32MalaCards
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MalaCards organs/tissues related to Mastitis:

32
Breast, Testes, Liver, Pituitary

Animal Models for Mastitis or affiliated genes

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Publications for Mastitis

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Sources:
50PubMed
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Articles related to Mastitis:

(show top 50)    (show all 692)
idTitleAuthorsYear
1
Tubercular mastitis - a great masquerader. (23354799)
2013
2
Occurrence and characterization of methicillin-resistant staphylococci from bovine mastitis milk samples in Finland. (23985065)
2013
3
Rapid mastitis detection assay on porous nitrocellulose membrane slides. (23912825)
2013
4
Bovine milk proteome: quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis. (23459212)
2013
5
Detection of the enterotoxigenic genes (sei,sej) in Staphylococcus aureus isolates from bovine mastitis milk in the West Azerbaijan of Iran. (23864850)
2013
6
Inferring relationships between clinical mastitis, productivity and fertility: a recursive model application including genetics, farm associated herd management, and cow-specific antibiotic treatments. (23859301)
2013
7
Integration of epidemiology into the genetic analysis of mastitis in Swedish Holstein. (23375969)
2013
8
Antimicrobial resistance in Staphylococcus aureus, Streptococcus uberis and Streptococcus dysgalactiae from dairy cows with mastitis. (24215609)
2013
9
Salidroside attenuates inflammatory responses by suppressing nuclear factor-I_B and mitogen activated protein kinases activation in lipopolysaccharide-induced mastitis in mice. (22915087)
2013
10
Genetic characteristics of CTX-M-type extended-spectrum-I^-lactamase (ESBL)-producing enterobacteriaceae involved in mastitis cases on Japanese dairy farms, 2007 to 2011. (23843488)
2013
11
Alpinetin attenuates inflammatory responses by interfering toll-like receptor 4/nuclear factor kappa B signaling pathway in lipopolysaccharide-induced mastitis in mice. (23669335)
2013
12
In vitro antimicrobial activity of Combretum molle (Combretaceae) against Staphylococcus aureus and Streptococcus agalactiae isolated from crossbred dairy cows with clinical mastitis. (22207479)
2012
13
Milk microbiome signatures of subclinical mastitis-affected cattle analysed by shotgun sequencing. (22277077)
2012
14
Draft genome sequence of Corynebacterium bovis DSM 20582, which causes clinical mastitis in dairy cows. (22843578)
2012
15
Observed and expected combined effects of clinical mastitis and low body condition on pregnancy loss in dairy cows. (21924482)
2012
16
Compromised neutrophil function and bovine E. coli mastitis: is C5a the missing link? (22858435)
2012
17
Alternative somatic cell count traits to improve mastitis resistance in Canadian Holsteins. (22192222)
2012
18
Joint estimation of genetic parameters for test-day somatic cell count and mastitis in the United Kingdom. (22818477)
2012
19
Bioeconomic modeling of intervention against clinical mastitis caused by contagious pathogens. (22863098)
2012
20
Investigation of the antibiotic resistance and biofilm formation of Staphylococcus aureus strains isolated from gangrenous mastitis of ewes. (22609990)
2012
21
Management of granulomatous mastitis: a series of 14 patients. (22731702)
2012
22
Genetic analysis of pathogen-specific clinical mastitis in Norwegian Red cows. (22365234)
2012
23
Hot topic: Bovine milk samples yielding negative or nonspecific results in bacterial culturing--the possible role of PCR-single strand conformation polymorphism in mastitis diagnosis. (22192188)
2012
24
Comparing effects of freezing at -196 A^C and -20 A^C on the viability of mastitis pathogens. (23327304)
2012
25
Quality of bulk tank milk samples from Danish dairy herds based on real-time polymerase chain reaction identification of mastitis pathogens. (22921631)
2012
26
Population diversity of Staphylococcus aureus isolated from bovine mastitis in Brazilian dairy herds. (22035658)
2012
27
Survey of marbofloxacin susceptibility of bacteria isolated from cattle with respiratory disease and mastitis in Europe. (22121154)
2012
28
Vaccination strategies for mastitis. (22664207)
2012
29
CD40 triggering induces strong cytotoxic T lymphocyte responses to heat-killed Staphylococcus aureus immunization in mice: a new vaccine strategy for staphylococcal mastitis. (22285272)
2012
30
Identification of Prototheca zopfii from Bovine Mastitis. (23113230)
2012
31
Recurrent Mastitis after Core Needle Biopsy: Case Report of an Unusual Complication after Core Needle Biopsy of a Phyllodes Tumor. (22872800)
2012
32
A HACCP-based approach to mastitis control in dairy herds. Part 2: Implementation and evaluation. (21777494)
2011
33
A HACCP-based approach to mastitis control in dairy herds. Part 1: Development. (21777489)
2011
34
Methotrexate in the management of idiopathic granulomatous mastitis: review of 108 published cases and report of four cases. (21951547)
2011
35
Changes in acute-phase proteins and cytokines in serum and milk whey from dairy cows with naturally occurring peracute mastitis caused by Klebsiella pneumoniae and the relationship to clinical outcome. (21712644)
2011
36
Evaluation of follow-up strategies for corticosteroid therapy of idiopathic granulomatous mastitis. (21365412)
2011
37
Etiology and antimicrobial susceptibility of udder pathogens from cases of subclinical mastitis in dairy cows in Sweden. (21649936)
2011
38
Effects of an immunomodulatory feed additive on the development of mastitis in a mouse infection model using four bovine-origin isolates. (22440767)
2011
39
The cost and management of different types of clinical mastitis in dairy cows estimated by dynamic programming. (21854920)
2011
40
The effect of taurine on the toll-like receptors/nuclear factor kappa B (TLRs/NF-I_B) signaling pathway in Streptococcus uberis-induced mastitis in rats. (21745598)
2011
41
Idiopathic granulomatous mastitis: a great imitator? (22798482)
2010
42
Idiopathic granulomatous mastitis: a 25-year experience. (18222379)
2008
43
Idiopathic granulomatous mastitis lesion mimicking inflammatory breast cancer. (17576978)
2007
44
Granulomatous mastitis and corynebacteria: clinical and pathologic correlations. (16174160)
2005
45
Phage conversion of exfoliative toxin A in Staphylococcus aureus isolated from cows with mastitis. (14516710)
2003
46
Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 cases. (12640102)
2003
47
The value of cytology in granulomatous mastitis: a report of 16 cases from Malaysia. (10711470)
2000
48
Acute mastitis; a novel presentation of relapsing polychondritis. (3451226)
1987
49
Granulomatous mastitis--a rare cause of erythema nodosum. (3658869)
1987
50
Prednisone management of granulomatous mastitis. (7191051)
1980

Genetic Variations for Mastitis

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Expression for genes affiliated with Mastitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mastitis

Search GEO for disease gene expression data for Mastitis.

Pathways for genes affiliated with Mastitis

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37NCBI BioSystems Database
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Pathways related to Mastitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3SELM, SELK, SELO
210.3SELM, SELK, SELO

Compounds for genes affiliated with Mastitis

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Mastitis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1exorphins4410.8CSN1S1, LTF
2cmpa4410.8CSN1S1, LALBA
3thiocyanate44 2411.8LPO, LTF, TST
4cyanide44 2411.8TST, HP, LPO
5lactose44 1111.8LALBA, HP, LTF, CSN1S1
6polyacrylic acid4410.8CSN1S1, VTN
7rifampicin44 28 5912.8LACTB, HP, LTF
8polyethylene glycol4410.8CSN1S1, HP, LALBA, VTN
9aspartate4410.8NDUFAB1, CSN1S1, LTF, VTN
10sodium dodecylsulfate4410.8VTN, LALBA, HP, CSN1S1
11whey4410.8LALBA, LTF, LPO, CSN1S1
12kininogen4410.7CSN1S1, HP, VTN
13urea44 11 2412.7CSN1S1, HP, LALBA, VTN
14sialic acid4410.7VTN, HP, LTF, LPO
15carbohydrates4410.7LALBA, HP, LTF, CSN1S1
16vitamin b124410.7CSN1S1, LTF, HP
17polysaccharide4410.7VTN, LALBA, HP, LTF, CSN1S1
18nacl4410.7CSN1S1, LTF, HP, LALBA
19fibrinogen4410.7CSN1S1, LTF, HP, LALBA, VTN
20selenium44 2411.7SELM, SELK, GPX5, LPO
21hypothiocyanite44 2411.7LTF, LPO
22lactulose4410.7LTF, NOD2
23ovomucoid4410.7CSN1S1, LALBA
24succinate4410.7LTF, CSN1S1, NDUFAB1
25polyacrylamide4410.7LALBA, HP, LTF, CSN1S1
26sodium chlorate4410.7LTF, VTN
27iron44 2411.7NDUFAB1, LPO, LTF, HP, LALBA, TST
28lactate4410.7NDUFAB1, CSN1S1, LPO, HP, VTN
29phenolphthalein44 1111.7LPO, LTF
30heparin44 28 11 2413.7CSN1S1, LTF, HP, LALBA, VTN
31ascorbic acid44 2411.6HP, LTF, LPO, CSN1S1
32alanine4410.6VTN, LALBA, HP, LTF, CSN1S1, NDUFAB1
33aprotinin44 1111.6LALBA, LTF, CSN1S1
34trichloroacetic acid4410.6LALBA, CSN1S1
35ampicillin44 1111.6LTF, LACTB
36methionine4410.5CSN1S1, LPO, HP, LALBA
37amoxicillin44 49 1112.5LACTB, LTF
38cysteine4410.4CSN1S1, LPO, LTF, HP, LALBA, VTN
39gliadin4410.4LALBA, CSN1S1
40mannitol44 1111.4LALBA, NOD2, CSN1S1
41serine4410.3CSN1S1, LTF, HP, CXCL6, NOD2, LACTB
42ofloxacin44 2 1112.3LTF, LACTB
43metronidazole44 1111.1LTF, LACTB

GO Terms for genes affiliated with Mastitis

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16Gene Ontology
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Biological processes related to Mastitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to oxidative stressGO:00697910.3SELK, GPX5, LPO
2defense response to bacteriumGO:04274210.1LALBA, NOD2, HP, LTF

Molecular functions related to Mastitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00820110.4VTN, CXCL6, LTF

Products for genes affiliated with Mastitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mastitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet