Mastitis malady

Wikipedia: Mastitis is the inflammation of breast tissue.S. aureus is the most common etiological organism...⁴⁴ more...

MalaCards: Mastitis, also known as inflammatory disorder of breast (disorder), is related to behcet's disease and immunodeficiency. An important gene associated with Mastitis is HP (haptoglobin), and among its related pathways are Bacterial infections in CF airways and HETE and HPETE biosynthesis and metabolism. The compounds ivig and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Aliases & Descriptions:

mastitis 6 8 32 43 inflammatory disorder of breast (disorder) 6 inflammatory breast disease nos (disorder) 6 inflammatory disease of breast (& ) 6 breast inflammation nos (disorder) 6 inflammatory disease of breast 6

inflammatory breast disease 6 breast inflammation nos 6 inflammatory disorder 43 mastitis (disorder) 6 mastitis nos 6

Diseases related to mastitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 589)

id	Related Disease	Score	Top Affiliating Genes
1	behcet's disease	27.2	IL8, TNF, TNFRSF1B, CP
2	immunodeficiency	27.0	BPI, ITGB2, IL6, TNF, LTF, TLR2
3	chronic infantile neurological cutaneous articular syndrome	26.5	IL1B, IL1R1, IL1RN
4	blau syndrome	26.3	IL1B, TNF, NOD2, CSF1
5	arthritis	25.9	IL1B, IL6, IL8, TNF
6	asthma	25.7	CD14, IL1B, CCL5, ALOX5, TNF, PLA2G7
7	rheumatoid arthritis	25.5	IL1B, IL1RN, TNF, NOD2
8	myositis	25.3	BCL2L1, IL1B, IL1RN, IL6, IL8, TNFRSF1B
9	urticaria	25.2	ITGB2, IL1R1, IL8, GPX1, ALOX5, TNF
10	thrombocytosis	25.1	IL1B, IL6, ALB, HP, CSF2
11	familial mediterranean fever	23.2	SAA1, CD14, IL1B, IL1R1, IL1RN, IL6
12	amyloidosis	23.1	VTN, SAA1, CD14, IL1B, IL1R1, IL1RN
13	celiac disease	21.8	LALBA, CD14, IL1B, IL1RN, IL6, CCL5
14	osteoporosis	21.7	ITGB2, IL1B, IL1R1, IL1RN, IL6, ALB
15	crohn's disease	21.3	BPI, LBP, IL1B, IL1R1, IL1RN, IL6
16	vasculitis	20.4	BPI, CD14, ITGB2, FN1, IL1B, IL1R1
17	allergic rhinitis	19.8	CD14, IL1B, IL1R1, IL1RN, IL6, IL8
18	glomerulonephritis	19.5	VTN, LALBA, ITGB2, FN1, IL1B, IL1R1
19	rhinitis	19.3	LACTB, CD14, IL1B, IL1R1, IL1RN, IL6
20	sarcoidosis	19.2	VTN, BCL2L1, CD14, FN1, IL1B, IL1R1
21	obesity	17.2	BPI, LBP, SAA1, CD14, ITGB2, IL1B
22	atherosclerosis	16.1	VTN, BCL2L1, LBP, SAA1, CD14, ITGB2
23	leukemia	14.3	CNKSR2, VTN, SETBP1, SELM, SELK, SEPN1
24	perinatal necrotizing enterocolitis	13.9	LACTB, PLA2G7, LTF, CSN1S1
25	reactive arthritis	13.8	BPI, LBP, HP, LTF
26	bacteremia, protection against	13.8	BPI, LBP, LACTB, SLPI
27	keshan disease	13.7	GPX4, GPX5, GPX1
28	spermatic cord torsion	13.7	GPX4, GPX5, GPX1
29	primary sclerosing cholangitis	13.6	BPI, LTF, SLPI, GGT1
30	eosinophilic gastroenteritis	13.4	ALB, CSN1S1, CSN3
31	staphyloenterotoxemia	13.4	SETBP1, SELM, SELK, SELO, FUT2, TST
32	dental caries	13.4	LPO, ALB, LTF, CSN1S1, LYZ
33	phenylketonuria	13.3	GPX4, GPX5, GPX1, ALB, CSN1S1
34	multicentric reticulohistiocytosis	13.2	TNF, CSF1, LYZ
35	bronchitis	13.2	LACTB, IL8, LTF, SLPI
36	pancytopenia	13.2	HP, DHFR, CSF1, CSF2, CP
37	protein-energy malnutrition	13.2	ALB, HP, LTF, CSN1S1, CP, GGT1
38	familial cold autoinflammatory syndrome	13.2	SAA1, IL1B, IL1R1
39	bilirubin metabolic disorder	13.1	ALB, HP, OXT, GGT1
40	pulmonary tuberculosis	13.1	CD14, HP, TLR2, CXCR1, CP
41	laryngeal cancer	13.1	BCL2L1, HP, NOD2, CSF1, SLPI, CP
42	hyper-igd syndrome	13.1	SAA1, IL1RN, TNF
43	galactosemia	13.1	VTN, ALB, SLPI, CP, GGT1
44	opportunistic bacterial infectious disease	13.0	LACTB, TNF, DHFR
45	cellulitis	13.0	LACTB, IL1R1, TNF, C5AR1
46	granulocytopenia	13.0	TNF, CSF2, CP
47	extrinsic allergic alveolitis	13.0	VTN, CD14, IL8
48	primary biliary cirrhosis	13.0	ALB, LTF, SLPI, CP, GGT1
49	meningococcemia	13.0	BPI, IL1B, IL1RN, CCL5
50	schnitzler syndrome	12.9	IL1R1, IL1RN, TNF

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to mastitis:

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MGI Mouse Phenotypes related to mastitis:

²⁵ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.8	C5AR1, CSF2, CXCL6, NOD2, BCL2L1, SELK
2	endocrine/exocrine gland phenotype	MP:0005379	9.7	GGT1, CSN3, CSN2, TLR2, EDNRA, ETV5
3	liver/biliary system phenotype	MP:0005370	8.5	STAT5A, TLR4, TLR2, GH1, GPX4, IL6
4	integument phenotype	MP:0010771	8.2	OXT, CSF1, CSF2, CSN1S1, CSN2, CSN3
5	skeleton phenotype	MP:0005390	7.4	C5AR1, CSF2, CSF1, NOD2, TNFRSF1B, ALOX5
6	immune system phenotype	MP:0005387	7.3	SELK, GGT1, C5AR1, CSF2, CXCL6, STAT5A
7	adipose tissue phenotype	MP:0005375	6.9	CSF2, STAT5A, TLR4, TLR2, TNFRSF1B, TNF
8	reproductive system phenotype	MP:0005389	6.6	STAT5A, OXT, CSF1, CSF2, CSN1S1, CSN2
9	mortality/aging	MP:0010768	5.8	TLR2, TLR4, STAT5A, OXT, CXCL6, CSF1
10	cardiovascular system phenotype	MP:0005385	5.3	EDNRA, TLR2, TLR4, OXT, CSF1, CSF2
11	homeostasis/metabolism phenotype	MP:0005376	5.2	OXT, STAT5A, TLR4, TLR2, EDNRA, LTF
12	cellular phenotype	MP:0005384	5.0	TNF, TNFRSF1B, NOD2, TLR2, TLR4, STAT5A

Articles related to mastitis:

(show all 33)

id	Title	Authors	Year	Affiliating Genes
1	Differentially expressed genes associated with Staphy lococcus aureus mastitis in dairy goats. (20060596)	Pisoni G.... Castiglioni B.	2010	CXCL6
2	Determination of milk and blood concentrations of lipopolysaccharide-binding protein in cows with naturally acquired subclinical and clinical mastitis. (19233791)	Zeng R.... Bannerman D.D.	2009	LBP
3	Analytical specificity and sensitivity of a real-time polymerase chain reaction assay for identification of bovine mastitis pathogens. (19233788)	Koskinen M.T.... Salmikivi L.	2009	LACTB
4	First description of NOD2 variant associated with def ective neutrophil responses in a woman with granulomatous mastitis related to c orynebacteria. (19641059)	Bercot B.... Elbim C.	2009	NOD2
5	The response of HEK293 cells transfected with bovine TLR2 to established pathogen-associated molecular patterns and to bacteria causing mastitis in cattle. (18621422)	Farhat K.... Jungi T.W.	2008	IL8, TLR2
6	Fibrinogen and ceruloplasmin in plasma and milk from dairy cows with subclinical and clinical mastitis. (18817128)	Tabrizi A.D.... Ahmadi M.	2008	CP
7	Milk enzyme activities and subclinical mastitis among women in Guinea-Bissau. (19086824)	Rasmussen L.B.... Larsen T.	2008	NDUFAB1
8	A peptide derived from human bactericidal/permeability-increasing protein (BPI) exerts bactericidal activity against Gram-negative bacterial isolates obtained from clinical cases of bovine mastitis. (17560054)	Chockalingam A.... Bannerman D.D.	2007	BPI
9	Dependence between acute phase response, oxidative status and mastitis of cows. (16780184)	Kleczkowski M.... Sikora J.	2006	HP
10	Relationships between symptoms and changes in breast physiology during lactation mastitis. (17661590)	Fetherston C.M.... Hartmann P.E.	2006	LTF
11	Delayed neutrophil apoptosis in bovine subclinical mastitis. (15545372)	Boutet P.... Lekeux P.	2004	BCL2L1, STAT5A, CSF2
12	Short-term changes of mRNA expression of various inflammatory factors and milk proteins in mammary tissue during LPS-induced mastitis. (14757184)	Schmitz S.... Bruckmaier R.M.	2004	PLA2G7, LTF, ALOX5
13	Acute phase protein concentrations in serum and milk from healthy cows, cows with clinical mastitis and cows with extramammary inflammatory conditions. (15074326)	Nielsen B.H.... Heegaard P.M.	2004	HP
14	Indicators of inflammation in the diagnosis of mastitis. (14556695)	PyAPrAolAo S.	2003	HP
15	Phage conversion of exfoliative toxin A in Staphylococcus aureus isolated from cows with mastitis. (14516710)	Endo Y.... Takeuchi S.	2003	EDNRA
16	Increased nuclear factor kappaB activity in milk cells of mastitis-affected cows. (12741551)	Boulanger D.... Lekeux P.	2003	CSF1
17	Anti-inflammatory effects of intramammary infusions of glycyrrhizin in lactating cows with mastitis caused by coagulase-negative staphylococci. (14596456)	Kai K.... Kumagai K.	2003	LTF, LALBA
18	Do lactoferrin, lysozyme and the lactoperoxidase-thiocyanate-hydrogen peroxide-system cause negative microbiological results in mastitis secretions? (12161968)	Schmedt Auf Der GA1nne H.... Heuwieser W.	2002	LTF
19	Human milk anti-inflammatory component contents during acute mastitis. (11520075)	Buescher E.S.... Hair P.S.	2001	TNFRSF1B, IL1R2
20	Acute phase response in naturally occurring coliform mastitis. (11459016)	Ohtsuka H.... Kawamura S.	2001	HP
21	Acute phase proteins in serum and milk from dairy cows with clinical mastitis. (11202551)	Eckersall P.D.... Fitzpatrick J.L.	2001	HP
22	Mastitis and transmission of human immunodeficiency virus through breast milk. (11131699)	Semba R.D.	2000	LTF
23	Occurrence of the blaZ gene in penicillin resistant Staphylococcus aureus isolated from bovine mastitis in Denmark. (10605145)	Vesterholm-Nielsen M.... Moller Aarestrup F.	1999	LACTB
24	Mastitis and immunological factors in breast milk of human immunodeficiency virus-infected women. (10776180)	Semba R.D.... Chiphangwi J.D.	1999	SLPI
25	Mastitis and immunological factors in breast milk of lactating women in Malawi. (10473515)	Semba R.D.... Chiphangwi J.D.	1999	LTF, CCL5, SLPI
26	Factors associated with clinical mastitis incidence in French dairy herds during late gestation and early lactation. (9601148)	Barnouin J.... Chassagne M.	1998	GGT1
27	Comparison of antibiotic administration in conjunctio n with supportive measures versus supportive measures alone for treatment of da iry cows with clinical mastitis. (9731263)	Morin D.E.... McCoy G.C.	1998	OXT
28	Phenotypic characterization of Streptococcus dysgalactiae isolates from bovine mastitis by their binding to host derived proteins. (8560738)	RantamAoki L.K.... MA1ller H.P.	1995	ALB
29	Administration of recombinant human interleukin 1 receptor antagonist during endotoxin-induced mastitis in cows. (7771698)	Shuster D.E.... Kehrli M.E.	1995	IL1R1, IL1RN
30	Lactoperoxidase activity and thiocyanate content of milk from cows with mastitis in different lactation stages (7646426)	Vobis V.... Kramer A.	1995	LPO
31	Isolation and characterization of alpha 2-macroglobulin from mastitis milk. (1383300)	Rantamaki L.K.... Muller H.P.	1992	A2M
32	Effects of endotoxin-induced mastitis on the pharmacokinetic properties of aditoprim in dairy cows. (1476314)	Lohuis J.A.... van Werven T.	1992	DHFR
33	Identification of staphylococci from bovine mastitis and an examination of their susceptibility to antibiotics and beta-lactamase production. (2287129)	Matsunaga T.... Uchida K.	1990	LACTB

Genes related to mastitis according to GeneCards:

(show top 50)    (show all 78)

id	Symbol	Description	Score	GeneCards Section Context
1	HP	haptoglobin	11.0	Publications
2	LTF	lactotransferrin	11.0	Publications
3	VTN	vitronectin	11.0
4	CSN1S1	casein alpha s1	11.0
5	LACTB	lactamase, beta	11.0	Publications
6	PIH2	pregnancy-induced hypertension syndrome-related protein	11.0
7	GLYCAM1	glycosylation dependent cell adhesion molecule 1 (pseudogene)	11.0
8	SELM	selenoprotein M	11.0
9	SELK	selenoprotein K	11.0
10	NKRF	NFKB repressing factor	11.0
11	GPX5	glutathione peroxidase 5 (epididymal androgen-related protein)	11.0
12	NDUFAB1	NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa	11.0	Publications
13	MMD	monocyte to macrophage differentiation-associated	11.0
14	ZNF582	zinc finger protein 582	11.0	Disorders
15	SELO	selenoprotein O	11.0	Disorders
16	KDELR1	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1	11.0
17	SUMF2	sulfatase modifying factor 2	11.0
18	TST	thiosulfate sulfurtransferase (rhodanese)	11.0
19	CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	11.0	Publications
20	MAST1	microtubule associated serine/threonine kinase 1	11.0
21	OR6C3	olfactory receptor, family 6, subfamily C, member 3	11.0	Disorders
22	NUCB1	nucleobindin 1	11.0
23	LALBA	lactalbumin, alpha-	11.0	Publications
24	CSN3	casein kappa	11.0
25	MSRB2	methionine sulfoxide reductase B2	11.0
26	SEPN1	selenoprotein N, 1	11.0
27	LYZ	lysozyme	11.0
28	IL1R2	interleukin 1 receptor, type II	11.0	Publications
29	HPR	haptoglobin-related protein	11.0
30	LPO	lactoperoxidase	11.0	Publications
31	CSN2	casein beta	11.0
32	SDCBP	syndecan binding protein (syntenin)	11.0
33	BPI	bactericidal/permeability-increasing protein	11.0	Publications
34	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
35	LBP	lipopolysaccharide binding protein	11.0	Publications
36	A2M	alpha-2-macroglobulin	11.0	Publications
37	C4BPA	complement component 4 binding protein, alpha	11.0
38	FUT2	fucosyltransferase 2 (secretor status included)	11.0
39	GPX4	glutathione peroxidase 4	11.0
40	ETV5	ets variant 5	11.0
41	PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	11.0	Publications
42	SAA1	serum amyloid A1	11.0
43	CXCR1	chemokine (C-X-C motif) receptor 1	11.0
44	STAT5A	signal transducer and activator of transcription 5A	11.0	Publications
45	MARCH8	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	11.0	Disorders
46	C5AR1	complement component 5a receptor 1	11.0
47	GPX1	glutathione peroxidase 1	11.0
48	CNKSR2	connector enhancer of kinase suppressor of Ras 2	11.0
49	EDNRA	endothelin receptor type A	11.0	Publications
50	ST5	suppression of tumorigenicity 5	11.0

Pathways related to mastitis according to GeneDecks:

(show top 50)    (show all 71)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.4	TLR2, IL1R1, LBP
2	HETE and HPETE biosynthesis and metabolism41	10.0	EPHX2, ALOX5, GPX1, GPX4
3	RAR-Gamma-RXR-Alpha Degradation36	10.0	CSF2, CSF1, CXCL6, CCL5
4	HETE and HPETE biosynthesis and metabolism10	9.9	EPHX2, ALOX5, GPX1, GPX4
5	Immune response_Bacterial infections in normal airways41	9.6	IL1R1, IL1B, CD14, LBP
6	Immune System38	9.6	CSF2, GH1, GLYCAM1, IL1R2, IL1R1, SAA1
7	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	9.5	IL6, CD14, LBP
8	Arachidonic acid metabolism20	9.5	GGT1, EPHX2, ALOX5, GPX1, GPX5
9	Transcription_NF-kB signaling pathway41	9.2	TLR4, TNFRSF1B, TNF, IL1R1, CD14, LBP
10	Transcription NF-kB signaling pathway10	9.2	TLR4, TNF, IL1R1, CD14, LBP
11	HMGB1 Pathway36	9.0	TLR4, TNF, IL1R2, IL1R1, IL1B
12	TRAF Pathway36	8.7	TLR4, TLR2, TNFRSF1B, TNF, IL1R1, IL1B
13	Endothelin-1 Signaling Pathway36	8.7	CSF1, CXCL6, EDNRA, CCL5, IL6, IL1B
14	MSP-RON Signaling36	8.7	CSF1, TLR4, TLR2, TNF, IL1B, ITGB2
15	Th17 Differentiation37	8.6	STAT5A, TLR4, TLR2, IL6, IL1R1, IL1B
16	Cytokine production by Th17 cells in CF41	8.4	CSF2, CXCL6, TLR4, IL8, IL6, CD14
17	Cytokine production by Th17 cells in CF (Mouse model)41	8.4	CD14, IL6, IL8, TLR4, CXCL6, CSF2
18	Akt Signaling36	8.3	CSF2, CSF1, CXCL6, TNF, CCL5, IL6
19	Immune response_TLR signaling pathways41	8.2	TLR4, TLR2, IL8, IL6, FN1, CD14
20	Molecular Mechanisms of Cancer36	8.2	CXCL6, TNFRSF1B, GH1, CCL5, IL6, IL1R1
21	ERK Signaling36	8.1	ITGB2, FN1, IL1B, IL6, CCL5, CXCL6
22	Toll-Like Receptor Signaling Pathways37	8.0	TLR4, TLR2, IL6, IL1B, CD14
23	IL-10 Pathway36	8.0	TLR4, TNF, IL6, IL1B, CD14, BCL2L1
24	Immune response IL-1 signaling pathway10	8.0	CP, TNF, IL8, IL6, IL1R1, IL1B
25	Immune response_IL-1 signaling pathway41	8.0	CP, TNF, IL8, IL6, IL1R1, IL1B
26	NOD-like receptor signaling pathway20	8.0	NOD2, TNF, CCL5, IL8, IL6, IL1B
27	Tec Kinases Signaling36	7.9	STAT5A, TLR4, TLR2, TNFRSF1B, GH1, CCL5
28	Rho Family GTPases36	7.8	CSF2, CSF1, CXCL6, GH1, CCL5, IL8
29	Hematopoietic cell lineage20	7.7	CSF2, CSF1, TNF, IL6, IL1R2, IL1R1
30	NF-KappaB (p50-p65) Pathway36	7.7	TLR4, TLR2, TNFRSF1B, TNF, GH1, IL6
31	NF-KappaB Family Pathway36	7.7	TLR4, TLR2, TNFRSF1B, TNF, GH1, IL6
32	Immune response_MIF in innate immunity response41	7.7	CD14, IL1B, IL6, IL8, TNF, TLR4
33	Immune response MIF in innate immunity response10	7.7	TLR4, LBP, CD14, IL1B, IL6, IL8
34	Chagas disease (American trypanosomiasis)20	7.6	TLR4, TLR2, TNF, CCL5, IL8, IL6
35	Malaria20	7.6	TLR4, ITGB2, IL1B, IL6, IL8, TNF
36	IL-6 Pathway36	7.4	CSF2, CSF1, CXCL6, TNF, CCL5, IL8
37	Tuberculosis20	7.4	TLR4, TLR2, NOD2, TNF, IL6, IL1B
38	all-trans-Retinoic Acid Signaling in Brain36	7.4	CSF2, CSF1, CXCL6, TNF, ALOX5, CCL5
39	PEDF Induced Signaling36	7.4	CSF2, CSF1, CXCL6, TNF, CCL5, IL8
40	Pertussis20	7.3	CXCL6, TLR4, C4BPA, TNF, IL8, IL6
41	STAT3 Pathway36	7.3	CSF2, CSF1, CXCL6, TNFRSF1B, TNF, CCL5
42	Toll-like receptor signaling pathway20	7.2	TLR4, TLR2, TNF, CCL5, IL8, IL6
43	PAK Pathway36	7.0	CSF2, CSF1, CXCL6, TNF, GH1, CCL5
44	MIF Mediated Glucocorticoid Regulation36	7.0	CSF2, CSF1, CXCL6, TLR4, TNF, CCL5
45	MIF Regulation of Innate Immune Cells36	7.0	TLR4, CXCL6, CSF1, CSF2, TNF, CCL5
46	p38 Signaling36	6.9	TNF, TNFRSF1B, CXCL6, CSF1, CSF2, GH1
47	Cytokine-cytokine receptor interaction20	6.8	CSF2, CSF1, CXCR1, CXCL6, TNFRSF1B, TNF
48	Antioxidant Action of Vitamin-C36	6.8	CSF2, CSF1, CXCL6, PLA2G7, TNFRSF1B, TNF
49	Rheumatoid arthritis20	6.8	TLR4, CXCL6, CSF1, CSF2, TLR2, TNF
50	Amoebiasis20	6.3	CD14, CSF2, TLR4, TLR2, TNF, IL8

Compounds related to mastitis according to GeneDecks:

(show top 50)    (show all 272)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.0	CSF2, PLA2G7, CSF1
2	hyaluronic acid32 18	10.8	LTF, ETV5, FN1, ITGB2, VTN, GGT1
3	whey32	9.7	CSN3, SLPI, CSN2, CSN1S1, STAT5A, LTF
4	ascorbic acid32 18	10.5	GPX4, ALOX5, LTF, DHFR, OXT, CSN1S1
5	endotoxin32	8.8	C5AR1, SLPI, CXCR1, EDNRA, LTF, PLA2G7
6	estrogen32	8.8	CSN2, CSN1S1, OXT, EDNRA, LTF, PLA2G7
7	aspartate32	8.6	HP, ALOX5, ITGB2, CD14, LALBA, LBP
8	oxygen32 18	9.2	STAT5A, CXCL6, CXCR1, CP, SLPI, TLR2
9	calcitriol32 42 9 18 9	12.1	ALOX5, TLR2, CSF1, CSF2, ALB, CCL5
10	muramyl dipeptide32	8.0	TLR4, TLR2, NOD2, IL8, IL1B, CSF2
11	sb 20358032 42	8.9	CCL5, IL6, IL1R1, ITGB2, BCL2L1, C5AR1
12	iron32 18	8.9	CSN2, TLR4, TST, EDNRA, NDUFAB1, LTF
13	pge232	7.8	LTF, PLA2G7, TNFRSF1B, HP, ALOX5, GPX4
14	heparin32 9 18 9	10.7	A2M, HP, ALOX5, ALB, CCL5, IL1RN
15	creatinine32	7.6	GH1, HP, CCL5, IL1RN, IL1R1, FN1
16	h2o232	7.4	HP, ALOX5, GPX1, GPX4, CCL5, IL1RN
17	rantes32	7.3	C5AR1, SLPI, CD14, CSF2, CSF1, CXCR1
18	cysteine32	7.1	CSN2, CSN1S1, CSF2, OXT, DHFR, EDNRA
19	gm-csf32	6.9	BCL2L1, CD14, IL1B, CSF2, CSF1, STAT5A
20	arachidonic acid32 9 18 9	9.8	EPHX2, C5AR1, CSF2, CXCR1, OXT, TLR4
21	prednisolone32 9 9	8.8	ITGB2, IL1R1, CD14, IL1RN, IL6, EDNRA
22	lipoteichoic acid32	6.8	SLPI, TLR4, TLR2, TNF, IL8, IL6
23	neopterin32	6.8	LTF, TNFRSF1B, TNF, HP, IL8, IL6
24	arginine32	6.7	C5AR1, EPHX2, GGT1, DHFR, VTN, CP
25	polymyxin b32	6.7	TLR4, TLR2, LTF, TNF, IL8, IL6
26	peptidoglycan32	6.6	LBP, CD14, TLR4, TLR2, NOD2, TNF
27	pentoxifylline32 9 9	8.6	GGT1, CSF2, LTF, TNF, HP, IL8
28	il 1032	6.3	CSF2, LBP, IL1B, CSF1, TLR4, TLR2
29	hydrocortisone32 9 9	8.3	CSF2, STAT5A, LTF, TNF, GH1, CCL5
30	cholesterol32 9 18 9	9.0	EDNRA, A2M, PLA2G7, TNFRSF1B, HP, ALB
31	fmlp32	6.0	C5AR1, FN1, ITGB2, CD14, BPI, IL1B
32	superoxide32 18	7.0	LBP, LPO, TLR2, LTF, PLA2G7, TNFRSF1B
33	leukotriene b432 42 18	7.8	ALOX5, CCL5, IL8, IL6, IL1RN, IL1R1
34	actinomycin d32	5.8	CSF2, CSF1, CXCR1, TLR4, TLR2, LTF
35	vitamin d32	5.8	CCL5, IL6, IL1RN, IL1R1, FN1, ITGB2
36	indomethacin32 9 9	7.8	TNF, GH1, ALOX5, ALB, CCL5, IL6
37	fibrinogen32	5.7	C5AR1, HP, ALB, IL6, IL1RN, IL1R1
38	cyclosporin a32 42	6.7	TLR2, EDNRA, LTF, TNFRSF1B, TNF, HP
39	pd 98,05932	5.4	CSN2, CSF2, C5AR1, STAT5A, TLR2, TNF
40	genistein32 9 18 9	8.4	CXCR1, BCL2L1, ITGB2, FN1, CSN1S1, SLPI
41	alanine32	5.1	STAT5A, IL1RN, IL1R1, FN1, ITGB2, CD14
42	nitric oxide32 9 18 9	8.0	TNFRSF1B, TNF, HP, GPX1, CCL5, IL8
43	histamine32 18	5.9	CCL5, IL8, IL6, IL1RN, IL1B, ITGB2
44	lipid32	4.8	IL6, IL1RN, IL1R1, ITGB2, CD14, SAA1
45	lactate32	4.4	DHFR, TLR4, C4BPA, NDUFAB1, TNF, GH1
46	retinoic acid32 42 18	6.3	DHFR, TLR4, TLR2, LTF, TNFRSF1B, TNF
47	serine32	4.2	IL1RN, IL1R1, FN1, ITGB2, CD14, LACTB
48	cycloheximide32	4.0	CCL5, IL8, IL6, IL1RN, IL1R1, IL1B
49	vegf32	3.5	OXT, TNFRSF1B, LTF, BPI, IL1B, IL1R1
50	dexamethasone32 42 34 9 9	7.2	TLR4, TLR2, EDNRA, LTF, PLA2G7, TNFRSF1B

Cellular components related to mastitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	4.6	HP, GH1, TNF, A2M, OXT, CXCL6
2	extracellular region	GO:005576	4.1	LYZ, GH1, TNFRSF1B, PLA2G7, LTF, A2M

Biological processes related to mastitis according to GeneDecks:

(show all 37)

id	Name	GO ID	Score	Top Affiliating Genes
1	defense response to bacterium	GO:042742	10.2	LYZ, TLR4, LTF, NOD2, LALBA, BPI
2	positive regulation of tumor necrosis factor biosynthetic process	GO:042535	10.1	TLR4, TLR2, LBP
3	positive regulation of nitric-oxide synthase biosynthetic process	GO:051770	10.1	NOD2, TLR2, TLR4
4	response to oxidative stress	GO:006979	10.1	TLR4, GPX5, GPX4, LPO, SELK
5	positive regulation of inflammatory response	GO:050729	10.0	PLA2G7, EDNRA, TLR2, TLR4, STAT5A
6	cellular response to lipoteichoic acid	GO:071223	9.9	TLR4, TLR2, CD14, LBP
7	positive regulation of neutrophil chemotaxis	GO:090023	9.7	IL8, LBP, EDNRA
8	positive regulation of tumor necrosis factor production	GO:032760	9.7	TLR4, TLR2, NOD2, CD14, LBP
9	negative regulation of interleukin-6 production	GO:032715	9.6	TLR4, TNF, BPI
10	positive regulation of interleukin-8 production	GO:032757	9.6	LBP, IL1B, TLR2, TLR4
11	response to activity	GO:014823	9.6	OXT, TLR4, TNF, CCL5
12	Toll signaling pathway	GO:008063	9.6	TLR4, TLR2, NOD2, CD14, LBP
13	positive regulation of cytokine secretion	GO:050715	9.5	TLR2, TNF, CD14, SAA1
14	positive regulation of osteoclast differentiation	GO:045672	9.5	CSF1, TNF, CCL5
15	chronic inflammatory response to antigenic stimulus	GO:002439	9.4	TNF, IL1RN, IL1B
16	positive regulation of fever generation	GO:031622	9.4	TNF, CCL5, IL1B
17	elevation of cytosolic calcium ion concentration	GO:007204	9.4	C5AR1, OXT, EDNRA, IL1B, SAA1
18	cellular response to lipopolysaccharide	GO:071222	9.4	TLR4, TNFRSF1B, IL8, CD14, LBP
19	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.4	TNFRSF1B, TNF, IL1B
20	negative regulation of growth of symbiont in host	GO:044130	9.3	TLR2, TNF, LBP
21	positive regulation of JAK-STAT cascade	GO:046427	9.3	GH1, CCL5, IL6
22	acute-phase response	GO:006953	9.2	LBP, SAA1, FN1, IL1RN, IL6
23	positive regulation of JNK cascade	GO:046330	9.2	TLR4, NOD2, TNF, IL1B, SDCBP
24	positive regulation of NF-kappaB import into nucleus	GO:042346	9.2	TLR4, TLR2, TNF, IL1B
25	neutrophil chemotaxis	GO:030593	9.2	C5AR1, IL8, IL1B, ITGB2, SAA1
26	positive regulation of nitric oxide biosynthetic process	GO:045429	9.1	IL1B, TNF, TLR2, TLR4
27	defense response to Gram-positive bacterium	GO:050830	9.1	C5AR1, TLR2, TNF, IL6, LBP
28	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.0	ST5, TLR4, EDNRA, NOD2, TNF, IL1B
29	activation of MAPK activity	GO:000187	9.0	C5AR1, TLR4, NOD2, TNF, IL1B
30	innate immune response	GO:045087	9.0	CSF1, TLR4, TLR2, C4BPA, NOD2, IL1R1
31	lipopolysaccharide-mediated signaling pathway	GO:031663	9.0	TLR4, TLR2, TNF, CCL5, IL1B, LBP
32	positive regulation of chemokine production	GO:032722	9.0	TLR4, TLR2, TNF, IL6, LBP
33	immune response	GO:006955	8.7	C5AR1, CSF2, CXCL6, TLR4, TLR2, IL8
34	response to glucocorticoid stimulus	GO:051384	8.2	OXT, TNF, CCL5, IL6, IL1RN, IL1B
35	positive regulation of interleukin-6 production	GO:032755	8.2	TLR4, TLR2, NOD2, TNF, IL6, IL1B
36	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.2	TLR4, TLR2, NOD2, TNF, IL6, IL1B
37	inflammatory response	GO:006954	6.3	CD14, EPHX2, LYZ, CSF1, CXCR1, CXCL6

Molecular functions related to mastitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	glutathione peroxidase activity	GO:004602	10.2	GPX4, GPX5, GPX1
2	lipopolysaccharide binding	GO:001530	9.5	BPI, LBP, CD14, TLR4
3	lipoteichoic acid binding	GO:070891	9.4	TLR2, CD14, LBP