MCID: MST005
MIFTS: 56

Mastitis

Categories: Reproductive diseases, Endocrine diseases

Aliases & Classifications for Mastitis

MalaCards integrated aliases for Mastitis:

Name: Mastitis 12 51 41 14 69
Inflammation of Non-Human Mammary Gland 69
Inflammatory Disorder of Breast 69
Inflammatory Disease of Breast 12
Inflammatory Breast Disease 12
Breast Inflammation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10690
MeSH 41 D008413
NCIt 46 C53662
ICD10 32 N61

Summaries for Mastitis

MalaCards based summary : Mastitis, also known as inflammation of non-human mammary gland, is related to pneumonia and mycobacterium kansasii, and has symptoms including signs and symptoms in breast An important gene associated with Mastitis is LTF (Lactotransferrin), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Hydrocortisone and Histamine have been mentioned in the context of this disorder. Affiliated tissues include testes, neutrophil and breast, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 72 Mastitis is inflammation of the breast or udder, usually associated with breastfeeding. Symptoms... more...

Related Diseases for Mastitis

Diseases related to Mastitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 pneumonia 30.1 CCL5 CXCL8 IL6 TLR2
2 mycobacterium kansasii 30.1 CXCL8 TLR2
3 bone inflammation disease 29.8 CXCL8 IL17A IL6
4 conjunctivitis 29.7 CXCL8 ICAM1 IL6
5 meningitis 29.7 ALB CXCL8 IL6 TLR2
6 arthritis 29.5 CSF2 CXCL8 IL17A IL6 NOD2
7 uveitis 29.4 ICAM1 IL17A NOD2
8 endometritis 29.4 HP IL6 OXT
9 psoriasis 29.0 CCL5 CXCL8 ICAM1 IL17A IL6
10 peritonitis 29.0 ALB CXCL8 ICAM1 IL6 LBP TLR2
11 granulomatous mastitis 12.4
12 granulomatous lobular mastitis 12.4
13 neonatal infective mastitis 12.1
14 eosinophilic mastitis 12.0
15 breast abscess 11.3
16 toxic shock syndrome 11.3
17 inflammatory breast carcinoma 11.2
18 diabetic mastopathy 11.2
19 mycobacterium chelonae 10.6 CXCL8 TLR2
20 recurrent corneal erosion 10.5 CXCL8 IL6
21 scorpion envenomation 10.5 CCL5 IL6
22 bagassosis 10.5 CXCL8 IL6
23 haemophilus influenzae 10.5 CXCL8 LTF TLR2
24 vaginal disease 10.4 CXCL8 IL6 SLPI
25 pouchitis 10.4 CXCL8 LTF NOD2
26 obesity-hypoventilation syndrome 10.4 CCL5 IL6
27 meningitis and encephalitis 10.4 ALB CP
28 gingivitis 10.4 CXCL8 IL6 LTF
29 bacterial vaginosis 10.4 CXCL8 IL6 TLR2
30 leptospirosis 10.4 CXCL8 IL6 TLR2
31 keratoconjunctivitis sicca 10.4 ALB IL6 LTF
32 acute generalized exanthematous pustulosis 10.4 CXCL8 IL17A
33 neurosyphilis 10.4 IL17A TLR2
34 infective endocarditis 10.4 IL6 LBP TLR2
35 acute cystitis 10.4 ALB CXCL8 IL6
36 acute pyelonephritis 10.4 ALB CXCL8 IL6
37 toxicodendron dermatitis 10.4 CXCL8 ICAM1
38 viral encephalitis 10.4 CCL5 CXCL8 IL6
39 periodontitis, chronic 10.4 IL6 TLR2
40 pyelonephritis 10.4 ALB CXCL8 IL6
41 viral meningitis 10.4 CCL5 CXCL8 IL6
42 dengue hemorrhagic fever 10.4 ALB CXCL8 IL6
43 felty syndrome 10.4 CSF2 CXCL8 LTF
44 chlamydia 10.4 CXCL8 IL6 TLR2
45 obstructive jaundice 10.3 ALB CXCL8 IL6
46 bronchitis 10.3 ALB CXCL8 SLPI
47 transverse myelitis 10.3 CXCL8 IL17A IL6
48 acute transverse myelitis 10.3 CXCL8 IL6
49 gastroenteritis 10.3 ALB CXCL8 IL6
50 herpes simplex virus keratitis 10.3 CXCL8 ICAM1

Comorbidity relations with Mastitis via Phenotypic Disease Network (PDN):


Acute Cystitis Fat Necrosis of Breast
Female Breast Cancer Hypertension, Essential
Microglandular Adenosis

Graphical network of the top 20 diseases related to Mastitis:



Diseases related to Mastitis

Symptoms & Phenotypes for Mastitis

UMLS symptoms related to Mastitis:


signs and symptoms in breast

GenomeRNAi Phenotypes related to Mastitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 9.17 LBP
2 Decreased viability GR00381-A-1 9.17 CSN3 LBP LTF
3 Decreased viability GR00381-A-3 9.17 CSN3 LBP LTF

MGI Mouse Phenotypes related to Mastitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.22 TLR2 LBP LTF NOD2 SLPI CXCL6
2 homeostasis/metabolism MP:0005376 10.21 SLPI TLR2 LBP LTF NOD2 OXT
3 endocrine/exocrine gland MP:0005379 10.13 TLR2 OXT IL6 CSN3 LALBA ALB
4 immune system MP:0005387 10.13 SLPI TLR2 LBP LTF NOD2 CXCL6
5 digestive/alimentary MP:0005381 10 TLR2 NOD2 OXT IL6 ALB ICAM1
6 integument MP:0010771 9.86 TLR2 OXT CSN2 CSN3 IL6 LALBA
7 liver/biliary system MP:0005370 9.7 TLR2 LBP LTF IL6 HP ALB
8 neoplasm MP:0002006 9.5 TLR2 LTF IL6 HP ALB ICAM1
9 renal/urinary system MP:0005367 9.17 TLR2 OXT IL6 HP ALB IL17A

Drugs & Therapeutics for Mastitis

Drugs for Mastitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 657311 5754
2
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
3
Butyric Acid Experimental, Investigational Phase 4 107-92-6 264
4 Cortisol succinate Phase 4
5 Hydrocortisone 17-butyrate 21-propionate Phase 4
6 Hydrocortisone acetate Phase 4
7 Anti-Inflammatory Agents Phase 4
8 Dermatologic Agents Phase 4
9 Histamine Antagonists Phase 4
10
Histamine Phosphate Phase 4 51-74-1 65513
11 Hydrocortisone-17-butyrate Phase 4
12 Neurotransmitter Agents Phase 4
13
Amoxicillin Approved, Vet_approved Phase 2, Phase 3 26787-78-0 33613 2171
14
Cloxacillin Approved, Investigational, Vet_approved Phase 2, Phase 3 61-72-3 6098
15
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
16
Hydroxocobalamin Approved Phase 3 13422-51-0 5460373 44475014 11953898
17
Azithromycin Approved Phase 3 83905-01-5 53477736 447043 55185
18
B-Carotene Approved, Nutraceutical Phase 3 7235-40-7 5280489
19
Cyanocobalamin Approved, Nutraceutical Phase 3 68-19-9 44176380
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
21
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
22
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 3 13422-55-4
23
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
24
Nicotinamide Approved, Investigational, Nutraceutical Phase 3 98-92-0 936
25
Pyridoxal Approved, Nutraceutical Phase 3 66-72-8 1050
26
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 3 65-23-6 1054
27
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 3 83-88-5 493570
28
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 3 59-43-8 1130
29 Tocopherol Approved, Investigational, Nutraceutical Phase 3,Phase 2
30
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 68-26-8, 11103-57-4 445354
31
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 54670067 5785
32
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-02-9 14985
33 Anti-Bacterial Agents Phase 2, Phase 3
34 Antibiotics, Antitubercular Phase 2, Phase 3
35 Anti-Infective Agents Phase 2, Phase 3
36 Antitubercular Agents Phase 2, Phase 3
37 beta-Lactamase Inhibitors Phase 2, Phase 3
38 beta-Lactams Phase 2, Phase 3
39 Clavulanic Acid Phase 2, Phase 3
40 Lactams Phase 2, Phase 3
41 Antioxidants Phase 3,Phase 2
42 Micronutrients Phase 3,Phase 2
43 Protective Agents Phase 3,Phase 2
44 Trace Elements Phase 3,Phase 2
45 Carotenoids Phase 3
46 Nicotinic Acids Phase 3
47 Retinol palmitate Phase 3
48 Tocopherols Phase 3,Phase 2
49 Tocotrienols Phase 3,Phase 2
50 Vitamin B 12 Phase 3

Interventional clinical trials:

(show all 19)

# Name Status NCT ID Phase Drugs
1 Medical and Surgical Treatment for Idiopathic Granulomatous Mastitis Recruiting NCT02959580 Phase 4 Hydrocortisone Butyrate
2 Use of Probiotic Lactobacilli for the Treatment of Lactational Mastitis Completed NCT00716183 Phase 2, Phase 3 Beta-lactam antibiotic
3 Partnership on Nutrition and HIV/AIDS Research in Tanzania: Exploratory Research Study on Selenium and HIV Infection Completed NCT00197561 Phase 3
4 Vitamins, Breastmilk HIV Shedding, and Child Health Completed NCT00197756 Phase 3
5 Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death Recruiting NCT03199547 Phase 3 Azithromycin;Placebo Oral Tablet
6 Study of a Probiotic Strain to Prevent Mastitis and to Eradicate GBS Colonization Unknown status NCT01505361 Phase 1, Phase 2
7 The Use of Pentoxifylline and Vitamin E in the Treatment of Chronic Breast Pain Terminated NCT00188669 Phase 2 pentoxifylline;alpha-Tocopherol
8 Survey of Optical Values of the Breast Using Radiation-Free Pressure-Free Optical Scanning Unknown status NCT00671385
9 Granulomatous Mastitis Current Approach and Treatment Completed NCT02667132
10 Evaluation of Lactobacillus Fermentum CECT5716 on the Incidence of Mastitis Completed NCT02203877
11 Staphylococcus Aureus Carrier Status in Breastfeeding Mothers and Infants and the Risk of Lactation Mastitis Completed NCT00620984
12 Global Effects of a Probiotic Strain on Lactating Women Completed NCT01124448
13 Study of Acupuncture and Care Interventions for the Treatment of Breast Inflammation During Breastfeeding Completed NCT00405158 Anti-pyretic medication, paracetamol;cefadroxil;penicillin;flucloxacillin
14 Nursing Education Intervention for Maternal Breastfeeding Completed NCT02106026
15 Painful Breastfeeding and Bacterial or Yeast Infection Completed NCT01631461
16 L.Fermentum CECT5716 in Treatment of Breast Pain Completed NCT02093338
17 Impact of Maternal Stress on Infant Stunting Completed NCT02755012
18 Acupuncture for Breast Engorgement During Lactation Recruiting NCT03230760
19 Ductal Lavage in Non-lactating Female Women With Mastitis Active, not recruiting NCT02794688

Search NIH Clinical Center for Mastitis

Cochrane evidence based reviews: mastitis

Genetic Tests for Mastitis

Anatomical Context for Mastitis

MalaCards organs/tissues related to Mastitis:

38
Testes, Neutrophil, Breast, Colon, Pituitary, Liver, Bone

Publications for Mastitis

Articles related to Mastitis:

(show top 50) (show all 977)
# Title Authors Year
1
Pathogenesis and inflammatory response in experimental caprine mastitis due to Staphylococcus chromogenes. ( 29360565 )
2018
2
Antibacterial activity of selected medicinal plants of northwest Pakistan traditionally used against mastitis in livestock. ( 29379373 )
2018
3
Frequency of enterotoxins, toxic shock syndrome toxin-1, and biofilm formation genes in Staphylococcus aureus isolates from cows with mastitis in the Northeast of Brazil. ( 29429115 )
2018
4
Biofilm-Forming Potential of Staphylococcus aureus Isolated from Clinical Mastitis Cases in New Zealand. ( 29351199 )
2018
5
Antimicrobial consumption on dairy herds and its association with antimicrobial inhibition zone diameters of non-aureus staphylococci and Staphylococcus aureus isolated from subclinical mastitis. ( 29398026 )
2018
6
Diagnosis and Treatment of 75 Patients with Idiopathic Lobular Granulomatous Mastitis. ( 29381437 )
2018
7
Molecular Characterization and Clonal Diversity of Methicillin-Resistant and -Susceptible Staphylococcus aureus Isolates of Milk of Cows with Clinical Mastitis in Tunisia. ( 29373088 )
2018
8
Tolerance to bovine clinical mastitis: Total, direct, and indirect milk losses. ( 29395137 )
2018
9
Subclinical mastitis (SCM) and proinflammatory cytokines are associated with mineral and trace element concentrations in human breast milk. ( 29413111 )
2018
10
Genomic investigation of Staphylococcus aureus isolates from bulk tank milk and dairy cows with clinical mastitis. ( 29426404 )
2018
11
The Effect of Some Natural Essential Oils Against Bovine Mastitis Caused by Prototheca zopfii Isolates In Vitro. ( 29380186 )
2018
12
Phenotypic and genotypic characterization of antimicrobial resistance profiles in Streptococcus dysgalactiae isolated from bovine clinical mastitis in 5 provinces of China. ( 29397161 )
2018
13
Addition of meloxicam to the treatment of bovine clinical mastitis results in a net economic benefit to the dairy farmer. ( 29398019 )
2018
14
The microbiology and treatment of human mastitis. ( 29350290 )
2018
15
Impact of subclinical mastitis on greenhouse gas emissions intensity and profitability of dairy cows in Norway. ( 29406080 )
2018
16
Infectious and Inflammatory Breast Disease. ( 29298955 )
2018
17
Imidazole decreases the ampicillin resistance of an Escherichia coli strain isolated from a cow with mastitis by inhibiting the function of autoinducer 2. ( 29397176 )
2018
18
Comparative effectiveness of individualised homeopathy and antibiotics in the treatment of bovine clinical mastitis: randomised controlled trial. ( 29374099 )
2018
19
Granulomatous Mastitis Concurrence with Breast Cancer. ( 29322122 )
2018
20
Lymphoepithelioma-Like Carcinoma of the Breast Mimicking Granulomatous Mastitis- Case Report and Review of the Literature ( 28749097 )
2017
21
Granulomatous mastitis: We need a useful classification system. ( 28864358 )
2017
22
Assessing the economic impact of an endemic disease: the case of mastitis. ( 28926014 )
2017
23
On-the-spot mastitis cell counts from hand-held gadget. ( 28883119 )
2017
24
Incidence of bovine clinical mastitis in Jammu region and antibiogram of isolated pathogens. ( 28919694 )
2017
25
Erythema nodosum in association with idiopathic granulomatous mastitis: a case series and review of the literature. ( 28271562 )
2017
26
Medicinal Plants Based Products Tested on Pathogens Isolated from Mastitis Milk. ( 28869568 )
2017
27
Idiopathic granulomatous mastitis: dilemmas in diagnosis and treatment. ( 29038724 )
2017
28
Biofilm production and beta-lactamic resistance in Brazilian Staphylococcus aureus isolates from bovine mastitis. ( 27913076 )
2017
29
Whole-Genome Sequence of Streptococcus parauberis Strain SP-llh, Isolated from Cows with Mastitis in Western China. ( 28082485 )
2017
30
Cystic neutrophilic granulomatous mastitis associated with Corynebacterium including Corynebacterium kroppenstedtii. ( 28442140 )
2017
31
Bilateral Lupus Mastitis During Pregnancy. ( 28926462 )
2017
32
Factors related to recurrence of idiopathic granulomatous mastitis: what do we learn from a multicentre study? ( 28749045 )
2017
33
Effects of intramammary infusion of sage (Salvia officinalis) essential oil on milk somatic cell count, milk composition parameters and selected hematology and serum biochemical parameters in Awassi sheep with subclinical mastitis. ( 28919679 )
2017
34
Steroids administered after vacuum-assisted biopsy in the management of idiopathic granulomatous mastitis. ( 28931582 )
2017
35
Idiopathic granulomatous mastitis associated with hyperprolactinemia: A nonoperative approach. ( 28845595 )
2017
36
Biofilm formation and antimicrobial resistance genes of coagulase-negative staphylococci isolated from cows with mastitis in Argentina. ( 28087612 )
2017
37
Idiopathic granulomatous mastitis: A diagnostic and therapeutic challenge. ( 28739122 )
2017
38
Follow-up of granulomatous mastitis with monitoring versus surgery. ( 28655119 )
2017
39
Molecular Characterization of Extended-Spectrum I^-Lactamase-Producing Escherichia coli Isolates from Milk Samples of Dairy Cows with Mastitis in Bavaria, Germany. ( 28953418 )
2017
40
Corrigendum to "Efficacy of a high free iodine barrier teat disinfectant for the prevention of naturally occurring new intramammary infections and clinical mastitis in dairy cows" (J. Dairy Sci. 100:3930-3939). ( 28923657 )
2017
41
Induction of heme oxygenas-1 attenuates NLRP3 inflammasome activation in lipopolysaccharide-induced mastitis in mice. ( 28938188 )
2017
42
I^-defensins: An innate defense for bovine mastitis. ( 28919695 )
2017
43
Exfoliation rate of mammary epithelial cells in milk on bovine mastitis caused by Staphylococcus aureus is associated with bacterial load. ( 28891152 )
2017
44
The enigma of granulomatous mastitis: A series. ( 29081405 )
2017
45
Factors affecting the cost-effectiveness of on-farm culture prior to the treatment of clinical mastitis in dairy cows. ( 28903881 )
2017
46
Risperidone Induced Granulomatous Mastitis Secondary to Hyperprolactinemia in a Non-Pregnant Woman-A Rare Case Report in a Bipolar Disorder. ( 28273980 )
2017
47
The effect of a cannula milk sampling technique on the microbiological diagnosis of bovine mastitis. ( 28911843 )
2017
48
Pituitary Adenoma and Hyperprolactinemia Accompanied by Idiopathic Granulomatous Mastitis. ( 28321344 )
2017
49
The microbiota of water buffalo milk during mastitis. ( 28926595 )
2017
50
Selenium suppresses inflammation by inducing microRNA-146a in<i>Staphylococcus aureus</i>-infected mouse mastitis model. ( 29340029 )
2017

Variations for Mastitis

Expression for Mastitis

Search GEO for disease gene expression data for Mastitis.

Pathways for Mastitis

Pathways related to Mastitis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 CCL5 CSF2 CXCL8 HP ICAM1 IL17A
2
Show member pathways
13.34 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
3
Show member pathways
13.26 CCL5 CSF2 CXCL8 ICAM1 IL17A IL6
4
Show member pathways
12.9 CCL5 CP CXCL8 IL6 NOD2 TLR2
5
Show member pathways
12.72 CCL5 CXCL8 ICAM1 IL6 TLR2
6
Show member pathways
12.48 CSF2 CXCL8 ICAM1 IL6 TLR2
7
Show member pathways
12.45 CCL5 CXCL8 IL6 LBP TLR2
8
Show member pathways
12.26 ALB CCL5 ICAM1 IL6
9
Show member pathways
12.18 CSF2 CXCL6 CXCL8 IL17A IL6 TLR2
10 12.16 IL6 LBP NOD2 TLR2
11
Show member pathways
12.11 CXCL8 IL6 LBP TLR2
12 11.89 CXCL8 ICAM1 IL17A IL6 LBP
13
Show member pathways
11.85 IL17A IL6 TLR2
14 11.84 CCL5 CSF2 ICAM1 IL6 NOD2
15 11.82 CXCL8 ICAM1 IL6
16 11.81 CSF2 CXCL8 IL6 TLR2
17 11.8 CXCL8 ICAM1 LBP
18
Show member pathways
11.77 IL17A IL6 TLR2
19 11.75 CSF2 CXCL8 IL6 LBP
20 11.68 CXCL6 CXCL8 IL6
21 11.61 ICAM1 IL6 TLR2
22 11.6 CCL5 CSF2 CXCL8 IL6
23
Show member pathways
11.58 CSF2 CXCL8 ICAM1 IL6
24 11.57 CSF2 CSN2 CXCL8 ICAM1 IL6
25 11.53 CXCL8 IL6 TLR2
26
Show member pathways
11.47 CSF2 CXCL6 CXCL8 ICAM1 IL17A IL6
27 11.45 CXCL8 ICAM1 IL6 TLR2
28 11.44 HP ICAM1 IL6
29 11.24 CCL5 CSF2 CXCL8 ICAM1 IL6
30 11.18 CCL5 CSF2 CXCL6 CXCL8 ICAM1 IL17A
31 11.03 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
32 10.92 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6

GO Terms for Mastitis

Cellular components related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ALB CCL5 CP CSF2 CSN2 CSN3
2 cell surface GO:0009986 9.65 ICAM1 LBP LTF NOD2 TLR2
3 extracellular space GO:0005615 9.55 ALB CCL5 CP CSF2 CSN2 CSN3
4 specific granule lumen GO:0035580 9.33 HP LTF SLPI

Biological processes related to Mastitis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.93 ALB CP IL6 LTF
2 inflammatory response GO:0006954 9.93 CCL5 CXCL6 CXCL8 IL17A IL6 TLR2
3 response to lipopolysaccharide GO:0032496 9.91 ICAM1 LBP SLPI TLR2
4 defense response GO:0006952 9.88 CXCL6 CXCL8 HP NOD2
5 chemokine-mediated signaling pathway GO:0070098 9.81 CCL5 CXCL6 CXCL8
6 defense response to Gram-positive bacterium GO:0050830 9.81 IL6 LALBA LBP TLR2
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 CCL5 CSF2 IL6
8 regulation of receptor activity GO:0010469 9.8 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
9 neutrophil chemotaxis GO:0030593 9.79 CCL5 CXCL6 CXCL8
10 defense response to Gram-negative bacterium GO:0050829 9.78 IL6 LALBA LBP LTF
11 positive regulation of tumor necrosis factor production GO:0032760 9.77 LBP NOD2 TLR2
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 ICAM1 IL6 LTF NOD2 TLR2
13 negative regulation of viral genome replication GO:0045071 9.76 CCL5 LTF SLPI
14 immune response GO:0006955 9.76 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
15 acute-phase response GO:0006953 9.74 HP IL6 LBP
16 cellular response to interleukin-1 GO:0071347 9.73 CCL5 CXCL8 ICAM1 IL17A
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 CCL5 LBP TLR2
18 positive regulation of neutrophil chemotaxis GO:0090023 9.71 CXCL6 CXCL8 LBP
19 positive regulation of interleukin-8 production GO:0032757 9.7 LBP NOD2 TLR2
20 positive regulation of chemokine production GO:0032722 9.67 IL6 LBP TLR2
21 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.66 IL17A NOD2
22 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.66 NOD2 TLR2
23 response to molecule of bacterial origin GO:0002237 9.65 CXCL8 TLR2
24 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.65 CCL5 CXCL8
25 cellular response to lipoteichoic acid GO:0071223 9.65 LBP TLR2
26 neutrophil mediated immunity GO:0002446 9.64 CXCL6 IL6
27 positive regulation of toll-like receptor 4 signaling pathway GO:0034145 9.63 LBP LTF
28 positive regulation of interleukin-6 production GO:0032755 9.62 IL6 LBP NOD2 TLR2
29 negative regulation of macrophage apoptotic process GO:2000110 9.61 CCL5 NOD2
30 positive regulation of interleukin-23 production GO:0032747 9.59 CSF2 IL17A
31 neutrophil activation GO:0042119 9.58 CCL5 CXCL6 CXCL8
32 cytokine secretion involved in immune response GO:0002374 9.56 NOD2 TLR2
33 cellular response to lipopolysaccharide GO:0071222 9.43 CSF2 CXCL6 CXCL8 ICAM1 IL6 LBP
34 defense response to bacterium GO:0042742 9.17 CXCL6 HP LALBA LBP LTF NOD2

Molecular functions related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CCL5 CXCL6 CXCL8
2 peptidoglycan binding GO:0042834 9.32 NOD2 TLR2
3 lipopeptide binding GO:0071723 9.26 LBP TLR2
4 lipopolysaccharide binding GO:0001530 9.13 LBP LTF TLR2
5 cytokine activity GO:0005125 9.1 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6

Sources for Mastitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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