MCID: MST005
MIFTS: 44

Mastitis malady

Reproductive category

Summaries for Mastitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Mastitis is the inflammation of breast tissue.S. aureus is the most common etiological organism... more...

MalaCards: Mastitis, also known as inflammatory disorder of breast, is related to toxic shock syndrome and systemic lupus erythematosus. An important gene associated with Mastitis is HP (haptoglobin), and among its related pathways are Selenium Pathway and Selenium Metabolism and Selenoproteins. The compounds exorphins and cmpa have been mentioned in the context of this disorder.

Aliases & Classifications for Mastitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive


Aliases & Descriptions:

mastitis 8 10 45
inflammatory disorder of breast 8
inflammatory breast disease nos 8
inflammatory disease of breast 8
inflammatory breast disease 8
breast inflammation nos 8
infectious mastitis 61
mastitis nos 8


External Ids:

Disease Ontology8 DOID:10690
MeSH35 D008413
NCIt40 C53662
ICD9CM27 611.0
ICD1025 N61

Related Diseases for Mastitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mastitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1toxic shock syndrome30.0SELM, LACTB, SELO, SELK
2systemic lupus erythematosus30.0CSN1S1, LTF, VTN, NOD2
3arthritis30.0VTN, LACTB, NOD2, CXCL6, CSN1S1, LTF
4granulomatous mastitis11.0
5mast syndrome10.2
6inflammatory breast carcinoma10.2
7diabetic mastopathy10.2
8neonatal infective mastitis10.1
9tuberculosis10.1
10klebsiella10.1
11mycobacterium abscessus10.1
12mycobacterium fortuitum10.1
13rhinotracheitis10.0
14calciphylaxis10.0
15breast lymphoma10.0
16peritonitis10.0LACTB
17pneumonia10.0VTN, LACTB
18protein-energy malnutrition10.0CSN1S1
19dysentery10.0LTF, LACTB
20periodontal disease10.0LTF
21staphyloenterotoxemia10.0SELO, SELK, SELM
22lactose intolerance10.0LTF, CSN1S1
23liver cirrhosis10.0CSN1S1, VTN, LACTB, LTF
24sepsis10.0LACTB, NOD2, CXCL6, LTF, VTN
25dental caries10.0LPO, CSN1S1, LTF
26cystic fibrosis10.0HP, LPO, LTF, LACTB
27perinatal necrotizing enterocolitis10.0LTF
28chronic kidney failure10.0LTF, HP, VTN, LACTB
29celiac disease10.0CSN1S1, LALBA
30asthma10.0CSN1S1, VTN, CXCL6, LPO, NOD2
31adenocarcinoma10.0VTN, CSN1S1
32diabetes mellitus10.0GPX5, VTN, HP, CSN1S1
33reactive arthritis10.0LTF, HP
34glomerulonephritis10.0VTN, CSN1S1
35atopic dermatitis10.0NOD2, CSN1S1, LALBA
36membranous glomerulonephritis10.0VTN, HP
37crohn's disease10.0LTF, NOD2
38breast reconstruction9.9
39prolactinoma9.9
40relapsing polychondritis9.9
41male breast cancer9.9
42granulomatous dermatitis9.9
43hyperprolactinemia9.9
44sweat gland carcinoma9.9
45wegener's granulomatosis9.9
46pasteurellosis9.9
47leukocyte adhesion deficiency9.9
48hidradenitis suppurativa9.9
49breast apocrine carcinoma9.9
50borderline leprosy9.9

Graphical network of the top 20 diseases related to Mastitis:



Diseases related to mastitis

Clinical Features for Mastitis

Drugs & Therapeutics for Mastitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Mastitis

Drug clinical trials:

Search ClinicalTrials for Mastitis

Search NIH Clinical Center for Mastitis

Search CenterWatch for Mastitis

Genetic Tests for Mastitis

Anatomical Context for Mastitis

Animal Models for Mastitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Mastitis

Sources:
51PubMed
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Articles related to Mastitis:

(show top 50)    (show all 692)
idTitleAuthorsYear
1
Prevalence of subclinical mastitis in dairy farms in urban and peri-urban areas of Kampala, Uganda. (23955012)
2014
2
Long-term outcome in idiopathic granulomatous mastitis: a western multicentre study. (23407345)
2013
3
Receiver-operating characteristic curves for somatic cell scores and California mastitis test in Valle del Belice dairy sheep. (23317658)
2013
4
Prevalence of subclinical mastitis and isolated udder pathogens in dairy cows in Southern Vietnam. (23212834)
2013
5
Antimicrobial susceptibilities of Mycoplasma isolated from bovine mastitis in Japan. (24261609)
2013
6
The changing face of mastitis in Irish dairy herds. (23832907)
2013
7
Molecular Characterization and Toxicity Confirmation of LukM/F'-PV Producing Staphylococcus aureus Isolated from Bovine Mastitis Samples in Mysore, India. (24426122)
2013
8
The effect of internal teat sealant products (Teatseal and Orbeseal) on intramammary infection, clinical mastitis, and somatic cell counts in lactating dairy cows: a meta-analysis. (24054298)
2013
9
Experience of treatment of patients with granulomatous lobular mastitis. (23833753)
2013
10
Idiopathic granulomatous mastitis: a mimicking disease in a pregnant woman: a case report. (23497626)
2013
11
Confirmation and fine-mapping of clinical mastitis and somatic cell score QTL in Nordic Holstein cattle. (23647142)
2013
12
Herd-level relationship between antimicrobial use and presence or absence of antimicrobial resistance in gram-negative bovine mastitis pathogens on Canadian dairy farms. (23769367)
2013
13
Incidence rates of clinical mastitis among Canadian Holsteins classified as high, average, or low immune responders. (23175290)
2013
14
Quantification of milk yield and composition changes as affected by subclinical mastitis during the current lactation in sheep. (24119805)
2013
15
Uncommitted role of enterococcal surface protein, Esp, and origin of isolates on biofilm production by Enterococcus faecalis isolated from bovine mastitis. (22520271)
2013
16
The relationship between the variants of the bovine MBL2 gene and milk production traits, mastitis, serum MBL-C levels and complement activity. (22771198)
2012
17
Herd characteristics and cow-level factors associated with Prototheca mastitis on dairy farms in Ontario, Canada. (22884347)
2012
18
Granulomatous mastitis: is it an autoimmune disease? Diagnostic and therapeutic dilemmas. (22068681)
2012
19
Histone H3K14 and H4K8 hyperacetylation is associated with Escherichia coli-induced mastitis in mice. (22419123)
2012
20
Behavioral changes in dairy cows with mastitis. (23040015)
2012
21
Plant essential oils and mastitis disease: their potential inhibitory effects on pro-inflammatory cytokine production in response to bacteria related inflammation. (22799106)
2012
22
Chimeric phage lysins act synergistically with lysostaphin to kill mastitis-causing Staphylococcus aureus in murine mammary glands. (22286996)
2012
23
A PCR assay and PCR-restriction fragment length polymorphism combination identifying the 3 primary Mycoplasma species causing mastitis. (22192198)
2012
24
Lupus mastitis without systemic disease: unusual imaging findings including MRI. (22616658)
2012
25
Costs of clinical mastitis with special reference to premature culling. (22192193)
2012
26
Completeness of the disease recording systems for dairy cows in Denmark, Finland, Norway and Sweden with special reference to clinical mastitis. (22866606)
2012
27
Idiopathic Granulomatous Mastitis as a Complication of Interferon-alpha Therapy. (23050257)
2012
28
Granulomatous mastitis complicated by arthralgia and erythema nodosum successfully treated with prednisolone and methotrexate. (23064576)
2012
29
Incidences of and genetic parameters for mastitis, claw disorders, and common health traits recorded in dairy cattle contract herds. (22459859)
2012
30
Development of an experimentally induced Streptococcus uberis subclinical mastitis in goats. (21924846)
2012
31
Molecular epidemiology of Staphylococcus aureus mastitis in dairy heifers. (22916896)
2012
32
Assessment and management of pain in dairy cows with clinical mastitis. (22664209)
2012
33
Short communication: Prevalence and risk factors of subclinical mastitis as determined by the California Mastitis Test in water buffaloes (Bubalis bubalis) in Nueva Ecija, Philippines. (22365218)
2012
34
Association of TLR4 polymorphisms with subclinical mastitis in Brazilian holsteins. (24031881)
2012
35
Granulomatous Mastitis during Chronic Antidepressant Therapy: Is It Possible a Conservative Therapeutic Approach? (23091553)
2012
36
Study of Staphylococcus aureus collected at slaughter from dairy cows with chronic mastitis. (22369758)
2012
37
Weber-Christian disease associated with granulomatous mastitis: a variant type of Weber-Christian disease? (20922452)
2011
38
Mycobacterium bovis mastitis in an alpaca and its implications. (21856673)
2011
39
Radiologic features of granulomatous mastitis. (21929558)
2011
40
Erythema nodosum associated with granulomatous mastitis: report of two cases. (19701754)
2010
41
Fibrinogen and ceruloplasmin in plasma and milk from dairy cows with subclinical and clinical mastitis. (18817128)
2008
42
Imaging findings in idiopathic granulomatous mastitis. A review with emphasis on magnetic resonance imaging. (15480037)
2004
43
Granulomatous mastitis diagnosed by core-needle biopsy and successfully treated with corticosteroid therapy: a case report. (14634520)
2003
44
Imprint cytology of non-specific granulomatous mastitis. (11530868)
2001
45
Occurrence of the blaZ gene in penicillin resistant Staphylococcus aureus isolated from bovine mastitis in Denmark. (10605145)
1999
46
Idiopathic granulomatous mastitis. Report of a case diagnosed with fine needle aspiration cytology. (10349385)
1999
47
Idiopathic granulomatous mastitis and extramammary manifestations. (7646321)
1995
48
Identification of staphylococci from bovine mastitis and an examination of their susceptibility to antibiotics and beta-lactamase production. (2287129)
1990
49
Granulomatous mastitis. (7195455)
1981
50
Postlactational tumoral granulomatous mastitis: a localized immune phenomenon. (464240)
1979

Genetic Variations for Mastitis

Expression for genes affiliated with Mastitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mastitis

Search GEO for disease gene expression data for Mastitis.

Pathways for genes affiliated with Mastitis

Sources:
38NCBI BioSystems Database
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Pathways related to Mastitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3SELM, SELK, SELO
210.3SELM, SELK, SELO

Compounds for genes affiliated with Mastitis

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Mastitis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1exorphins4510.8LTF, CSN1S1
2cmpa4510.8CSN1S1, LALBA
3thiocyanate45 2411.8TST, LTF, LPO
4cyanide45 2411.8TST, HP, LPO
5lactose45 1111.8LALBA, LTF, CSN1S1, HP
6polyacrylic acid4510.8CSN1S1, VTN
7rifampicin45 29 6012.8HP, LACTB, LTF
8polyethylene glycol4510.8CSN1S1, HP, LALBA, VTN
9aspartate4510.8CSN1S1, LTF, VTN, NDUFAB1
10sodium dodecylsulfate4510.8HP, VTN, LALBA, CSN1S1
11whey4510.8LALBA, LTF, LPO, CSN1S1
12kininogen4510.7HP, CSN1S1, VTN
13urea45 11 2412.7VTN, CSN1S1, HP, LALBA
14sialic acid4510.7LPO, LTF, HP, VTN
15carbohydrates4510.7CSN1S1, HP, LALBA, LTF
16vitamin b124510.7CSN1S1, LTF, HP
17polysaccharide4510.7VTN, CSN1S1, HP, LALBA, LTF
18nacl4510.7LALBA, CSN1S1, LTF, HP
19fibrinogen4510.7VTN, LALBA, HP, LTF, CSN1S1
20selenium45 2411.7SELM, SELK, GPX5, LPO
21hypothiocyanite45 2411.7LPO, LTF
22ovomucoid4510.7CSN1S1, LALBA
23succinate4510.7CSN1S1, LTF, NDUFAB1
24polyacrylamide4510.7LTF, CSN1S1, LALBA, HP
25sodium chlorate4510.7LTF, VTN
26iron45 2411.7NDUFAB1, LPO, LTF, LALBA, TST, HP
27lactulose4510.7NOD2, LTF
28phenolphthalein45 1111.7LPO, LTF
29lactate4510.7CSN1S1, NDUFAB1, LPO, HP, VTN
30heparin45 29 11 2413.7CSN1S1, HP, VTN, LALBA, LTF
31ascorbic acid45 2411.6LTF, CSN1S1, LPO, HP
32alanine4510.6NDUFAB1, LALBA, HP, LTF, VTN, CSN1S1
33aprotinin45 1111.6LALBA, LTF, CSN1S1
34trichloroacetic acid4510.6CSN1S1, LALBA
35ampicillin45 1111.6LACTB, LTF
36methionine4510.5LALBA, HP, LPO, CSN1S1
37amoxicillin45 50 1112.5LACTB, LTF
38cysteine4510.4CSN1S1, VTN, LTF, LALBA, LPO, HP
39gliadin4510.4CSN1S1, LALBA
40mannitol45 1111.4LALBA, CSN1S1, NOD2
41serine4510.3HP, CSN1S1, LTF, VTN, CXCL6, NOD2
42ofloxacin45 2 1112.3LACTB, LTF
43metronidazole45 1111.1LACTB, LTF

GO Terms for genes affiliated with Mastitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Mastitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to oxidative stressGO:00697910.3SELK, GPX5, LPO
2defense response to bacteriumGO:04274210.1LALBA, NOD2, HP, LTF

Molecular functions related to Mastitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00820110.4VTN, CXCL6, LTF

Products for genes affiliated with Mastitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mastitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet