MCID: MST009
MIFTS: 71

Mastocytosis malady

Genetic diseases, Rare diseases, Skin diseases, Immune diseases, Blood diseases, Cancer diseases categories

Summaries for Mastocytosis

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44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Mastocytosis is a disorder thatĀ can occur in both children and adults. it is caused by the presence of too many mast cells in the body.Ā mast cells contain substances such as histamine that regulate allergic reactions. signs and symptoms of mastocytosis may include musculoskeletal pain, abdominal discomfort, nausea, vomiting, ulcers, diarrhea, and skin lesions. treatment may include medications such as antihistaminesĀ (to prevent the effect of mast cell histamine) and anticholinergics (to relieve intestinal cramping).there are two broad categories of mastocytosis, cutaneous and systemic. cutaneous mastocytosis only affects the skin and is usually diagnosed in children. systemic mastocytosis affects more than one part of the body and is usually diagnosed in adults. gard provides additional information onĀ cutaneous mastocytosis and systemic mastocytosis. last updated: 1/16/2013

MalaCards: Mastocytosis, also known as mast cell disease, is related to systemic mastocytosis and urticaria pigmentosa, and has symptoms including follicular/erythematous/edematous papules/milium, pruritus/itching and abnormal pigmentary skin changes/skin pigmentation anomalies. An important gene associated with Mastocytosis is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Melanocyte Development and Pigmentation and Cardiac Progenitor Differentiation. The compounds monochloroacetic acid and mizoribine have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and bone marrow, and related mouse phenotypes are pigmentation and no phenotypic analysis.

Wikipedia:66 Mastocytosis, one of the mast cell diseases, is a rare disorder of both children and adults caused by... more...

Description from OMIM:48 154800

Aliases & Classifications for Mastocytosis

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50Orphanet, 63UMLS, 44NIH Rare Diseases, 23GTR, 11DISEASES, 46Novoseek, 21GeneTests, 48OMIM, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

50
urticaria pigmentosa:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

mastocytosis 44 23 11 46
mast cell disease 44 21 48
urticaria pigmentosa 50 63
maculopapular cutaneous mastocytosis 50
mast cell neoplasm 63


External Ids:

OMIM48 154800
MESH via Orphanet37 D014582
ICD10 via Orphanet27 Q82.2
SNOMED-CT via Orphanet60 78745000
UMLS via Orphanet64 C0042111
ICD1026 Q82.2

Related Diseases for Mastocytosis

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18GeneCards, 19GeneDecks
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Diseases in the Systemic Mastocytosis family:

mastocytosis

Diseases related to Mastocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 212)
idRelated DiseaseScoreTop Affiliating Genes
1systemic mastocytosis32.0PDGFRB
2urticaria pigmentosa31.1KIT, KITLG
3mast-cell leukemia30.7KITLG, KIT
4leukemia30.7HDC, IFNA2, IL2RA, PDGFRA, PDGFRB, KIT
5chronic myelomonocytic leukemia30.3PDGFRA, PDGFRB, KIT, KITLG
6hypereosinophilic syndrome30.2PDGFRA, PDGFRB, KIT
7eosinophilia30.2IFNA2, IL2RA, PDGFRA, PDGFRB, CD2
8myelodysplastic syndromes30.2KITLG, KIT, PDGFRB, PDGFRA
9sarcoma30.2PDGFRA, PDGFRB, KIT, KITLG
10myelofibrosis30.1IFNA2, PDGFRA, PDGFRB
11mast cell neoplasm30.1HDC, KIT, KITLG
12neurofibroma30.1KITLG, KIT, PDGFRB, PDGFRA
13uveitis30.1IL2RA, IFNA2
14myeloproliferative disorder30.0IFNA2, PDGFRA, PDGFRB, KIT, KITLG
15polycythemia vera30.0IFNA2, PDGFRA, PDGFRB, KIT, KITLG
16gastrointestinal stromal tumor29.9KIT, PDGFRA
17splenomegaly29.9IFNA2, IL2RA
18thrombocytosis29.9KITLG, IFNA2
19piebaldism29.8PDGFRA, KIT, KITLG
20melanoma29.7CD2, KITLG, KIT, PDGFRB, PDGFRA, IFNA2
21cutaneous mastocytosis11.0
22diffuse cutaneous mastocytosis10.7
23indolent systemic mastocytosis10.7
24urticaria10.6
25aggressive systemic mastocytosis10.6
26osteoporosis10.5
27acute myeloid leukemia10.5
28myeloid leukemia10.5
29sm-ahnmd10.3
30isolated bone marrow mastocytosis10.3
31mastocytosis cutaneous with short stature conductive hearing loss and microtia10.2
32syringoma10.2
33myeloma10.2
34smouldering systemic mastocytosis10.2
35pseudoxanthomatous diffuse cutaneous mastocytosis10.2
36mast-cell sarcoma10.2
37portal hypertension10.2
38hypertension10.2
39syncope10.2
40blindness10.2
41bullous diffuse cutaneous mastocytosis10.2
42cutaneous mastocytoma10.2
43microphthalmia10.2
44diarrhea10.1
45histiocytosis10.1
46b-cell lymphomas10.1
47systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease10.1
48acromegaly10.1
49lichen planus10.1
50celiac disease10.1

Graphical network of the top 20 diseases related to Mastocytosis:



Diseases related to mastocytosis

Symptoms for Mastocytosis

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48OMIM, 50Orphanet
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Symptoms by clinical synopsis from OMIM:

154800

Clinical features from OMIM:

154800

Symptoms:

50 (show all 14)
  • follicular/erythematous/edematous papules/milium
  • pruritus/itching
  • abnormal pigmentary skin changes/skin pigmentation anomalies
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • mastocytosis
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute diarrhea
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • facial pain/cephalalgia/migraine
  • hot flushes/sensation of cold
  • telangiectasiae of the skin
  • macules

Drugs & Therapeutics for Mastocytosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Mastocytosis

Drug clinical trials:

Search ClinicalTrials for Mastocytosis

Search NIH Clinical Center for Mastocytosis

Search CenterWatch for Mastocytosis

Genetic Tests for Mastocytosis

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21GeneTests, 23GTR
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Genetic tests related to Mastocytosis:

id Genetic test Affiliating Genes
1 Mast Cell Disease21 KIT
2 Mastocytosis23

Anatomical Context for Mastocytosis

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34MalaCards
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MalaCards organs/tissues related to Mastocytosis:

34
Bone, Skin, Bone marrow, Myeloid, Lung, Liver, B cells, Monocytes, Ovary, T cells, Breast, Testes, Small intestine, Heart, Brain, B lymphoblasts, Spleen, Lymph node

Animal Models for Mastocytosis or affiliated genes

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38MGI
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Publications for Mastocytosis

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53PubMed
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Articles related to Mastocytosis:

(show top 50)    (show all 892)
idTitleAuthorsYear
1
Orbital Involvement in Systemic Mastocytosis. (24410676)
2014
2
Mastocytosis, Kounis syndrome and medical emergencies. (24415350)
2014
3
Mastocytosis. (24262698)
2014
4
Mastocytosis: a paradigmatic example of a rare disease with complex biology and pathology. (23593539)
2013
5
Omalizumab Induced Remission of Idiopathic Anaphylaxis in a Patient Suffering from Indolent Systemic Mastocytosis. (24162824)
2013
6
Systemic mastocytosis - the importance of looking within bone marrow fragments. (24123109)
2013
7
Guidelines and diagnostic algorithm for patients with suspected systemic mastocytosis: a proposal of the Austrian competence network (AUCNM). (23675567)
2013
8
Systemic mastocytosis presenting as Kounis syndrome. (24267372)
2013
9
Cutaneous mastocytosis as a rare differential diagnosis for unilateral chronic facial pain and erythema: a case report. (24171187)
2013
10
Epidermal nevus syndrome with cutaneous mastocytosis. (22681453)
2012
11
Systemic mastocytosis: disease overview, pathogenesis, and treatment. (23009941)
2012
12
Involvement of a common progenitor cell in core binding factor acute myeloid leukaemia associated with mastocytosis. (22871474)
2012
13
Smouldering systemic mastocytosis presenting with cryptic life-threatening crises: case report and literature review. (22408224)
2012
14
Serotonin and its 5-HT1 receptor in human mastocytosis. (22268664)
2012
15
IL-5 receptor I+ levels in patients with marked eosinophilia or mastocytosis. (21762978)
2011
16
Anesthetic experience in a pediatric patient with mastocytosis. (22148097)
2011
17
Apoptosis, mastocytosis, and diminished adipocytokine gene expression accompany reduced epididymal fat mass in long-standing diet-induced obese mice. (22051061)
2011
18
Current approaches to the diagnosis and treatment of systemic mastocytosis. (20143640)
2010
19
Utility of the World Heath Organization classification criteria for the diagnosis of systemic mastocytosis in bone marrow. (19116630)
2009
20
Systemic mastocytosis presenting as osteoporosis--a case report. (19305945)
2009
21
The recent article on 'Mastocytosis and insect venom allergy: diagnosis, safety and efficacy of venom immunotherapy' by Niedoszytko et al. (19824888)
2009
22
Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients. (18186813)
2008
23
What's eating you? Bees, Part 2: Venom immunotherapy and mastocytosis. (17725061)
2007
24
Therapeutically relevant mutations in the receptor tyrosine kinase KIT in mastocytosis]. (18314612)
2007
25
A pilot study of nonmyeloablative allogeneic hematopoietic stem cell transplant for advanced systemic mastocytosis. (16400343)
2006
26
Interferon treatment for hypereosinophilic syndromes and systemic mastocytosis. (15995323)
2005
27
Bone marrow biopsies for the diagnosis of systemic mastocytosis: is one biopsy sufficient? (14983941)
2004
28
Response to therapy with interferon alpha-2b and prednisolone in aggressive systemic mastocytosis: report of five cases and review of the literature. (14687620)
2004
29
Multiple life-threatening fainting episodes: fatal systemic mastocytosis. (14719479)
2003
30
Expression of Bcl-2 and Bcl-xL in cutaneous and bone marrow lesions of mastocytosis. (12937123)
2003
31
Comment on systemic mastocytosis study. (12716379)
2003
32
Stem cell factor-induced bone marrow mast cell hyperplasia mimicking systemic mastocytosis (SM): histopathologic and morphologic evaluation with special reference to recently established SM-criteria. (12002761)
2002
33
Levels of mast-cell growth factors in plasma and in suction skin blister fluid in adults with mastocytosis: correlation with dermal mast-cell numbers and mast-cell tryptase. (11799370)
2002
34
Effect of granulocyte macrophage colony-stimulating factor in a patient with benign systemic mastocytosis. (11703299)
2001
35
Pathologic quiz case. Systemic mastocytosis. (10747334)
2000
36
c-Kit and c-kit mutations in mastocytosis and other hematological diseases. (10670573)
2000
37
Hematologic aspects of systemic mastocytosis. (10909040)
2000
38
Gastrointestinal abnormalities and involvement in systemic mastocytosis. (10909042)
2000
39
The effect of pamidronate on lumbar spine bone density and pain in osteoporosis secondary to systemic mastocytosis. (9133977)
1997
40
Successful treatment of osteoporosis in systemic mastocytosis with interferon alpha-2b. (8605279)
1996
41
Cutaneous mastocytosis in a dog. (1514225)
1992
42
Fibrous mastocytoma in a patient with generalized cutaneous mastocytosis. (1375950)
1992
43
Diffuse cutaneous mastocytosis, 22 years on. (2337526)
1990
44
Portal hypertension and ascites in systemic mastocytosis. (2608581)
1989
45
Bronchoalveolar mastocytosis in farmer's lung is related to the disease activity. (3377620)
1988
46
Hypotensive attacks due to systemic mastocytosis. (3591218)
1987
47
Effects of isoprenaline and terbutaline on urinary excretion of histamine and its two main metabolites in systemic mastocytosis. (3728212)
1986
48
Failure of sulfites to produce clinical responses in patients with systemic mastocytosis or recurrent anaphylaxis: results of a single-blind study. (3905921)
1985
49
Secretory diarrhea and prostaglandin D2 overproduction in systemic mastocytosis. (6953312)
1982
50
The isomorphic (Koebner) phenomenon in cutaneous mastocytosis. (6177175)
1981

Variations for Mastocytosis

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Expression for genes affiliated with Mastocytosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mastocytosis

Search GEO for disease gene expression data for Mastocytosis.

Pathways for genes affiliated with Mastocytosis

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 5Cell Signaling Technology, 61Thomson Reuters, 31KEGG, 52PharmGKB, 62Tocris Bioscience, 56Reactome
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Pathways related to Mastocytosis according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KIT, KITLG
29.6KIT, PDGFRA
39.4IL2RA, KIT, KITLG
49.3PDGFRA, PDGFRB
59.3PDGFRB, PDGFRA
6
Show member pathways
PDGF Pathway39
9.3PDGFRA, PDGFRB
79.2KIT, PDGFRA, IL2RA
8
Show member pathways
9.0KIT, PDGFRB, PDGFRA
9
Show member pathways
9.0KIT, PDGFRB, PDGFRA
108.9PDGFRB, PDGFRA, IL2RA
11
Show member pathways
8.9PDGFRB, PDGFRA, IL2RA
128.7PDGFRA, PDGFRB, KIT, KITLG
13
Show member pathways
8.7PDGFRA, PDGFRB, KIT, KITLG
14
Show member pathways
8.7KITLG, KIT, PDGFRB, PDGFRA
15
Show member pathways
8.7PDGFRA, PDGFRB, KIT, KITLG
168.7KITLG, KIT, PDGFRB, PDGFRA
17
Show member pathways
8.7KITLG, KIT, PDGFRB, PDGFRA
18
Show member pathways
8.7PDGFRA, PDGFRB, KIT, KITLG
19
Show member pathways
8.7PDGFRA, PDGFRB, KIT, KITLG
20
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
8.7PDGFRA, PDGFRB, KIT, KITLG
218.5IL2RA, KIT, KITLG, CD2
22
Show member pathways
8.2IL2RA, PDGFRA, PDGFRB, KIT, KITLG
238.2IL2RA, PDGFRA, PDGFRB, KIT, KITLG
24
Show member pathways
8.2IL2RA, PDGFRA, PDGFRB, KIT, KITLG
25
Show member pathways
8.2IL2RA, PDGFRA, PDGFRB, KIT, KITLG
26
Show member pathways
8.2IL2RA, PDGFRA, PDGFRB, KIT, KITLG
27
Show member pathways
8.2IL2RA, PDGFRA, PDGFRB, KIT, KITLG
28
Show member pathways
8.2KITLG, KIT, PDGFRB, PDGFRA, IL2RA
297.8IFNA2, IL2RA, PDGFRA, PDGFRB, KIT, KITLG
30
Show member pathways
7.4IL2RA, PDGFRA, PDGFRB, KIT, KITLG, CD2
31
Show member pathways
7.4IL2RA, PDGFRA, PDGFRB, KIT, KITLG, CD2
32
Show member pathways
7.4IL2RA, PDGFRA, PDGFRB, KIT, KITLG, CD2
33
Show member pathways
7.0IFNA2, IL2RA, PDGFRA, PDGFRB, KIT, KITLG
34
Show member pathways
7.0CD2, IFNA2, IL2RA, PDGFRA, PDGFRB, KIT

Compounds for genes affiliated with Mastocytosis

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Mastocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1monochloroacetic acid4610.2KITLG, KIT
2mizoribine4610.0IFNA2, IL2RA
3pentostatin46 62 30 1212.9IL2RA, IFNA2
4su6668469.9KIT, PDGFRB
5zd6474469.8PDGFRB, KIT
6hydroxychloroquine46 1210.8IFNA2, IL2RA
7cytarabine46 52 1211.7KITLG, KIT, IFNA2
8toluidine469.7KITLG, KIT
9dmpq dihydrochloride629.7PDGFRB, PDGFRA
10sunitinib malate629.7PDGFRB, PDGFRA
11su 6668629.7PDGFRA, PDGFRB
12su 16f629.7PDGFRA, PDGFRB
13gold469.6IFNA2, KITLG, KIT
14vincristine46 52 1211.6KIT, IL2RA, IFNA2
15su5416469.6KIT, KITLG, PDGFRB
16agarose469.6KIT, IFNA2, KITLG
17prednisolone46 30 1211.6KITLG, IL2RA, IFNA2
18pkc 412469.4PDGFRB, PDGFRA, KIT
19pazopanib52 1210.4PDGFRB, PDGFRA, KIT
20sunitinib46 52 1211.4KIT, PDGFRB, PDGFRA
21regorafenib52 1210.4PDGFRB, KIT, PDGFRA
22doxorubicin46 52 1211.4KIT, IL2RA, IFNA2, KITLG
23hydroxyurea46 52 1211.3PDGFRA, KIT, KITLG, IFNA2
24megestrol acetate469.3IL2RA, IFNA2
25cyclophosphamide46 52 1211.3IFNA2, IL2RA, KITLG
26con a469.2IFNA2, IL2RA, CD2
27ribonucleic acid469.2KITLG, PDGFRB, IFNA2, KIT
28tgf beta1469.2PDGFRA, PDGFRB, KITLG
29gp 130469.2PDGFRB, KIT, KITLG, IL2RA
30ag-1296469.1PDGFRA, PDGFRB, KIT, KITLG
31paclitaxel46 52 1211.1KITLG, KIT, PDGFRB, IL2RA
32imatinib46 52 1211.1KITLG, KIT, PDGFRB, PDGFRA
33histamine46 30 2511.0HDC, IFNA2, KITLG, IL2RA, KIT
34cisplatin46 52 62 1212.0PDGFRB, KITLG, IL2RA, IFNA2
35calcitriol46 62 25 1211.9PDGFRA, PDGFRB, KITLG, IL2RA
365fluorouracil468.8KIT, PDGFRB, IL2RA, KITLG, IFNA2
37aspartate468.8KIT, IL2RA, HDC, IFNA2, PDGFRA
38testosterone46 62 25 1211.7KITLG, KIT, PDGFRB, IL2RA
39h2o2468.7HDC, IL2RA, PDGFRB, KITLG
40rapamycin468.6PDGFRB, PDGFRA, IL2RA, KIT, KITLG
41paraffin468.6KITLG, PDGFRA, IL2RA, KIT, PDGFRB
42phosphatidylinositol468.6PDGFRA, KITLG, KIT, PDGFRB, IL2RA
43glucose468.3KITLG, KIT, PDGFRB, IFNA2, CD2
44retinoic acid46 259.3PDGFRB, PDGFRA, IFNA2, KIT, KITLG, HDC
45vegf468.3KITLG, IL2RA, PDGFRB, PDGFRA, IFNA2, KIT
46estrogen468.3IL2RA, IFNA2, KITLG, KIT, PDGFRB, PDGFRA
47thymidine46 259.1IL2RA, CD2, KITLG, KIT, PDGFRA, IFNA2
48lipid468.0SLC27A4, IFNA2, PDGFRB, KITLG, CD2
49calcium46 52 25 1210.7KIT, PDGFRA, HDC, KITLG, PDGFRB, CD2
50tyrosine467.1KITLG, KIT, PDGFRB, PDGFRA, IL2RA, IFNA2

GO Terms for genes affiliated with Mastocytosis

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17Gene Ontology
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Cellular components related to Mastocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:0098989.3CD2, KIT
2intrinsic component of plasma membraneGO:0312269.0PDGFRB, PDGFRA
3external side of plasma membraneGO:0098978.4CD2, KIT, PDGFRA, IL2RA
4plasma membraneGO:0058866.8IL2RA, PDGFRA, PDGFRB, KIT, KITLG, CD2

Biological processes related to Mastocytosis according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1ectopic germ cell programmed cell deathGO:03523410.1KIT, KITLG
2embryonic hemopoiesisGO:03516210.0KIT, KITLG
3positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.9IFNA2, KIT
4metanephric glomerular capillary formationGO:0722779.7PDGFRA, PDGFRB
5positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:0380919.6PDGFRA, PDGFRB
6retina vasculature development in camera-type eyeGO:0612989.6PDGFRA, PDGFRB
7positive regulation of DNA replicationGO:0457409.6PDGFRA, KITLG
8cardiac myofibril assemblyGO:0550039.6PDGFRA, PDGFRB
9adrenal gland developmentGO:0303259.5PDGFRA, PDGFRB
10positive regulation of MAP kinase activityGO:0434069.4KITLG, PDGFRB
11platelet-derived growth factor receptor signaling pathwayGO:0480089.4PDGFRA, PDGFRB
12positive regulation of phospholipase C activityGO:0108639.4KIT, PDGFRB, PDGFRA
13positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.4KIT, PDGFRB, PDGFRA
14cell chemotaxisGO:0603269.3PDGFRB, KIT, PDGFRA
15positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.3PDGFRB, PDGFRA, KIT
16wound healingGO:0420609.3PDGFRB, PDGFRA
17peptidyl-tyrosine phosphorylationGO:0181089.3PDGFRB, PDGFRA, KIT
18positive regulation of cell migrationGO:0303359.3KIT, PDGFRA, PDGFRB
19protein autophosphorylationGO:0467779.2KIT, PDGFRB, PDGFRA
20cell surface receptor signaling pathwayGO:0071669.0IL2RA, CD2, IFNA2
21phosphatidylinositol-mediated signalingGO:0480159.0PDGFRB, PDGFRA, KIT, KITLG
22fibroblast growth factor receptor signaling pathwayGO:0085439.0KITLG, KIT, PDGFRA, PDGFRB
23Fc-epsilon receptor signaling pathwayGO:0380959.0KITLG, KIT, PDGFRB, PDGFRA
24epidermal growth factor receptor signaling pathwayGO:0071739.0PDGFRA, KITLG, PDGFRB, KIT
25neurotrophin TRK receptor signaling pathwayGO:0480119.0KIT, KITLG, PDGFRA, PDGFRB
26positive regulation of cell proliferationGO:0082848.7PDGFRA, PDGFRB, KIT
27innate immune responseGO:0450878.6IFNA2, PDGFRA, PDGFRB, KITLG, KIT

Molecular functions related to Mastocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.6KIT, PDGFRA
2vascular endothelial growth factor bindingGO:0380859.3PDGFRB, PDGFRA
3platelet-derived growth factor bindingGO:0484079.2PDGFRB, PDGFRA
4platelet-derived growth factor receptor bindingGO:0051619.0PDGFRB, PDGFRA

Products for genes affiliated with Mastocytosis

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Sources for Mastocytosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet