Maternal Uniparental Disomy, Chromosome 14 malady

MalaCards: Maternal Uniparental Disomy, Chromosome 14, also known as uniparental disomy, is related to myelodysplastic syndrome and pituitary adenoma. An important gene associated with Maternal Uniparental Disomy, Chromosome 14 is FOXG1 (forkhead box G1). Related mouse phenotypes are other and embryogenesis.

maternal uniparental disomy, chromosome 14 16 uniparental disomy 43

Diseases related to maternal uniparental disomy, chromosome 14 by text searches and GeneDecks gene sharing:

(show top 50)    (show all 55)

id	Related Disease	Score	Top Affiliating Genes
1	myelodysplastic syndrome	12.1	MEG3, DLK1
2	pituitary adenoma	11.8	MEG3, DLK1
3	uniparental disomy of chromosome 11	9.0
4	leukemia	8.8
5	uniparental disomy of 13	8.8
6	uniparental disomy, paternal, chromosome 14	8.8
7	uniparental disomy of chromosome 2	8.5
8	chromosome 1, uniparental disomy 1q12 q21	8.1
9	chromosome 10, uniparental disomy	8.1
10	chromosome 16, uniparental disomy	8.1
11	chromosome 21, uniparental disomy	8.1
12	chromosome 5, uniparental disomy	8.1
13	uniparental disomy of 6	8.1
14	acute myeloid leukemia	7.6
15	carcinoma	7.6
16	myeloid leukemia	7.6
17	prader-willi syndrome	7.6
18	acute lymphoblastic leukemia	6.7
19	juvenile myelomonocytic leukemia	6.7
20	surfactant deficiency	6.7
21	angelman syndrome	6.7
22	lymphoblastic leukemia	6.7
23	stargardt disease	6.7
24	anhidrosis	6.7
25	mantle cell lymphoma	6.7
26	t-cell prolymphocytic leukemia	6.7
27	beckwith-wiedemann syndrome	6.7
28	myoclonus-dystonia	6.7
29	west syndrome	6.7
30	breast cancer	6.7
31	myoclonus	6.7
32	breast carcinoma	6.7
33	myeloid malignancy	6.7
34	basal cell carcinoma	6.7
35	myelomonocytic leukemia	6.7
36	central nervous system lymphoma	6.7
37	noonan syndrome	6.7
38	central precocious puberty	6.7
39	neurofibromatosis	6.7
40	costello syndrome	6.7
41	precocious puberty	6.7
42	embryonal rhabdomyosarcoma	6.7
43	prolymphocytic leukemia	6.7
44	epidermolysis bullosa	6.7
45	pycnodysostosis	6.7
46	hepatoblastoma	6.7
47	pyruvate kinase deficiency	6.7
48	hermaphroditism	6.7
49	rhabdomyosarcoma	6.7
50	21-hydroxylase deficiency	6.7

Approved drugs:

Drug clinical trials:

Genetic tests related to maternal uniparental disomy, chromosome 14:

id	Genetic test	Affiliating Genes
1	Maternal Uniparental Disomy, Chromosome 14 clinical/research

MGI Mouse Phenotypes related to maternal uniparental disomy, chromosome 14:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	other phenotype	MP:0005395	8.9	RTL1, DLK1
2	embryogenesis phenotype	MP:0005380	8.8	FOXG1, MEG3, RTL1
3	muscle phenotype	MP:0005369	8.6	FOXG1, MEG3, DLK1
4	growth/size phenotype	MP:0005378	8.1	FOXG1, MEG3, DLK1, RTL1
5	mortality/aging	MP:0010768	7.7	FOXG1, MEG3, DLK1, RTL1

Articles related to maternal uniparental disomy, chromosome 14:

id	Title	Authors	Year	Affiliating Genes
1	West syndrome associated with mosaic duplication of F OXG1 in a patient with maternal uniparental disomy of chromosome 14. (21910242)	Tohyama J.... Saitoh S.	2011	FOXG1
2	Molecular mechanisms regulating phenotypic outcome in paternal and maternal uniparental disomy for chromosome 14. (18698157)	Ogata T.... Ferguson-Smith A.C.	2008	DLK1, MEG3
3	Isolated imprinting mutation of the DLK1/GTL2 locus associated with a clinical presentation of maternal uniparental disomy of chromosome 14. (17601927)	Temple I.K.... Mackay D.J.	2007	DLK1

Genes related to maternal uniparental disomy, chromosome 14 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	FOXG1	forkhead box G1	11.1	Publications
2	RTL1	retrotransposon-like 1	11.1	UniProt Related
3	DLK1	delta-like 1 homolog (Drosophila)	11.1	Publications
4	MEG3	maternally expressed 3 (non-protein coding)	11.1	Publications

Biological processes related to maternal uniparental disomy, chromosome 14 according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	multicellular organismal development	GO:007275	9.0	DLK1, RTL1