MIDD
MCID: MTR046
MIFTS: 35

Maternally Inherited Diabetes and Deafness (MIDD) malady

Eye, Ear, Metabolic, Endocrine, Fetal categories

Summaries for Maternally Inherited Diabetes and Deafness

Sources:
21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
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Genetics Home Reference:21 Maternally inherited diabetes and deafness (MIDD) is a form of diabetes that is often accompanied by hearing loss, especially of high tones. The diabetes in MIDD is characterized by high blood sugar levels (hyperglycemia) resulting from a shortage of the hormone insulin, which regulates the amount of sugar in the blood. In MIDD, the diabetes and hearing loss usually develop in mid-adulthood, although the age that they occur varies from childhood to late adulthood. Typically, hearing loss occurs before diabetes.

MalaCards: Maternally Inherited Diabetes and Deafness, also known as MIDD, is related to macular dystrophy and focal segmental glomerulosclerosis, and has symptoms including cerebellum/cerebellar vermis anomaly/agenesis/hypoplasia, constipation and ataxia/incoordination/trouble of the equilibrium. An important gene associated with Maternally Inherited Diabetes and Deafness is MT-TL1 (mitochondrially encoded tRNA leucine 1 (UUA/G)), and among its related pathways is tRNA Aminoacylation. The compounds beta-hydroxybutyrate and gemfibrozil have been mentioned in the context of this disorder.

Wikipedia:64 Diabetes mellitus and deafness (DAD) or Maternally inherited diabetes and deafness (MIDD) is a subtype... more...

Description from OMIM:47 520000

Aliases & Classifications for Maternally Inherited Diabetes and Deafness

Sources:
43NIH Rare Diseases, 21Genetics Home Reference, 22GTR, 49Orphanet, 47OMIM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal
Anatomical: Eye, Ear, Metabolic, Endocrine


Characteristics (Orphanet epidemiological data):

49
midd:
Inheritance: Mitochondrial inheritance; Prevalence: 1-9/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

maternally inherited diabetes and deafness 43 21
midd 43 21 49
diabetes-deafness syndrome, maternally transmitted 43 22
maternally-inherited diabetes and deafness 49 47
noninsulin-dependent diabetes mellitus with deafness 21
maternally transmitted diabetes-deafness syndrome 21
mitochondrial inherited diabetes and deafness 21
diabetes and deafness, maternally inherited 43
diabetes mellitus, type ii, with deafness 21
diabetes mellitus type ii with deafness 43
ballinger wallace syndrome 43
ballinger-wallace syndrome 21
mitochondrial diabetes 49
niddm with deafness 21


External Ids:

OMIM47 520000
MESH via Orphanet36 C536246
ICD10 via Orphanet26 E13, H90.3
SNOMED-CT via Orphanet58 237619009
UMLS via Orphanet62 C0342289

Related Diseases for Maternally Inherited Diabetes and Deafness

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Maternally Inherited Diabetes and Deafness:



Diseases related to maternally inherited diabetes and deafness

Clinical Features for Maternally Inherited Diabetes and Deafness

Sources:
47OMIM, 49Orphanet
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Clinical features from OMIM:

520000

Clinical synopsis from OMIM:

520000

Symptoms:

49 (show all 23)
  • cerebellum/cerebellar vermis anomaly/agenesis/hypoplasia
  • constipation
  • ataxia/incoordination/trouble of the equilibrium
  • chronic arterial hypertension
  • diabetes mellitus
  • muscle weakness/flaccidity
  • cataract/lens opacification
  • malabsorption/chronic diarrhea/steatorrhea
  • sensorineural deafness/hearing loss
  • visual loss/blindness/amblyopia
  • proteinuria
  • retinopathy
  • renal failure
  • cardiomyopathy/hypertrophic/dilated
  • cardiac rhythm disorder/arrhythmia
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • hyperlipidemia/hypercholesterolemia/hypertriglyceridemia
  • heart/cardiac failure
  • myalgia/muscular pain
  • macular dystrophy/absence/hypoplasia of the macula
  • ophthalmoplegia/ophthalmoparesis/oculomotor palsy
  • renal glomerular defect/glomerulopathy
  • retinal/chorioretinal dysplasia/dystrophy

Drugs & Therapeutics for Maternally Inherited Diabetes and Deafness

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Maternally Inherited Diabetes and Deafness

Drug clinical trials:

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Search NIH Clinical Center for Maternally Inherited Diabetes and Deafness

Search CenterWatch for Maternally Inherited Diabetes and Deafness

Genetic Tests for Maternally Inherited Diabetes and Deafness

Sources:
22GTR
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Genetic tests related to Maternally Inherited Diabetes and Deafness:

id Genetic test Affiliating Genes
1 Diabetes-deafness Syndrome Maternally Transmitted22

Anatomical Context for Maternally Inherited Diabetes and Deafness

Animal Models for Maternally Inherited Diabetes and Deafness or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Maternally Inherited Diabetes and Deafness

Genetic Variations for Maternally Inherited Diabetes and Deafness

Expression for genes affiliated with Maternally Inherited Diabetes and Deafness

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Maternally Inherited Diabetes and Deafness

Search GEO for disease gene expression data for Maternally Inherited Diabetes and Deafness.

Pathways for genes affiliated with Maternally Inherited Diabetes and Deafness

Sources:
54Reactome, 30KEGG
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Pathways related to Maternally Inherited Diabetes and Deafness according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.2MT-TK, MT-TL1, MT-TE

Compounds for genes affiliated with Maternally Inherited Diabetes and Deafness

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience
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Compounds related to Maternally Inherited Diabetes and Deafness according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1beta-hydroxybutyrate459.4INS, CHKB
2gemfibrozil45 29 1111.4INS, CHKB
3rosuvastatin45 50 29 1112.4CHKB, INS
4bezafibrate45 29 1111.4CHKB, INS
5clozapine45 29 50 1112.3CHKB, GAD1
6olanzapine50 45 29 11 2413.3INS, CHKB
7streptozotocin459.2INS, GAD1
82-deoxyglucose45 1110.1INS, GAD1
9uric acid45 2410.1INS, CHKB
10carnitine459.0INS, CHKB
11levodopa45 1110.0CHKB, GAD1
12cyclosporin a45 29 6011.0GAD1, CHKB, PTPRN
13c-peptide458.8PTPRN, INS, GAD1
14creatinine458.6GAD1, CHKB, INS
15arginine458.3GAD1, CHKB, INS, PTPRN
16glutamate458.3GAD1, CHKB, INS, PTPRN
17glucose458.2PTPRN, INS, CHKB, GAD1

GO Terms for genes affiliated with Maternally Inherited Diabetes and Deafness

Products for genes affiliated with Maternally Inherited Diabetes and Deafness

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  • Proteins
  • Lysates
  • Antibodies

Sources for Maternally Inherited Diabetes and Deafness

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet