MILS
MCID: MTR017
MIFTS: 20

Maternally Inherited Leigh Syndrome (MILS) malady

Summaries for Maternally Inherited Leigh Syndrome

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Maternally inherited leigh syndrome (mils) is a progressive brain disorder that usually appears in infancy or early childhood. affected children may experience vomiting, seizures, delayed development, muscle weakness, and problems with movement. heart disease, kidney problems, and difficulty breathing can also occur in people with this disorder. mils is a subtype of leigh syndrome and is caused by changes in mitochondrial dna. mutations in at least 11 mitochondrial genes have been found to cause mils. this condition has an inheritance pattern known as maternal or mitochondrial inheritance. because mitochondria can be passed from one generation to the next only through egg cells (not through sperm cells), only females pass mils to their children. last updated: 12/29/2009

MalaCards: Maternally Inherited Leigh Syndrome, also known as MILS, is related to leigh disease and benign recurrent intrahepatic cholestasis 2. An important gene associated with Maternally Inherited Leigh Syndrome is MT-ATP6 (mitochondrially encoded ATP synthase 6). The compounds oligomycin and actomyosin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and kidney.

Aliases & Classifications for Maternally Inherited Leigh Syndrome

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

maternally inherited leigh syndrome 42 60
mils 42 60
subacute necrotizing encephalomyelopathy maternally inherited 42
leigh disease, maternally inherited 42


Related Diseases for Maternally Inherited Leigh Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Maternally Inherited Leigh Syndrome:



Diseases related to maternally inherited leigh syndrome

Clinical Features for Maternally Inherited Leigh Syndrome

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Drugs & Therapeutics for Maternally Inherited Leigh Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Maternally Inherited Leigh Syndrome

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Genetic Tests for Maternally Inherited Leigh Syndrome

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Anatomical Context for Maternally Inherited Leigh Syndrome

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32MalaCards
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MalaCards organs/tissues related to Maternally Inherited Leigh Syndrome:

32
Brain, Heart, Kidney

Animal Models for Maternally Inherited Leigh Syndrome or affiliated genes

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Publications for Maternally Inherited Leigh Syndrome

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Genetic Variations for Maternally Inherited Leigh Syndrome

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Expression for genes affiliated with Maternally Inherited Leigh Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Maternally Inherited Leigh Syndrome

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Pathways for genes affiliated with Maternally Inherited Leigh Syndrome

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Compounds for genes affiliated with Maternally Inherited Leigh Syndrome

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Maternally Inherited Leigh Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oligomycin449.5DNAH8, MT-ATP6
2actomyosin449.4PEX6, DNAH8
3prednisolone44 28 1111.1DNAH8, TNF
4calcitriol44 59 11 2412.1DNAH8, TNF
5curcumin448.8DNAH8, TNF
6atp44 289.7MT-ATP6, DNAH8, PEX6

GO Terms for genes affiliated with Maternally Inherited Leigh Syndrome

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16Gene Ontology
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Molecular functions related to Maternally Inherited Leigh Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATPase activityGO:0168879.3PEX6, DNAH8

Products for genes affiliated with Maternally Inherited Leigh Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Maternally Inherited Leigh Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet