MCID: MTR009
MIFTS: 29

Mature T-Cell and Nk-Cell Neoplasm malady

Cancer diseases category

Summaries for Mature T-Cell and Nk-Cell Neoplasm

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34MalaCards
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MalaCards: Mature T-Cell and Nk-Cell Neoplasm is related to anaplastic large cell lymphoma and cutaneous t cell lymphoma. An important gene associated with Mature T-Cell and Nk-Cell Neoplasm is CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)), and among its related pathways are MicroRNAs in cancer and Focal adhesion. The compounds eb 1089 and cetuximab have been mentioned in the context of this disorder. Affiliated tissues include t cells and nk cells, and related mouse phenotypes are adipose tissue and pigmentation.

Aliases & Classifications for Mature T-Cell and Nk-Cell Neoplasm

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9Disease Ontology
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mature t-cell and nk-cell neoplasm 9


External Ids:

Disease Ontology9 DOID:0050743

Related Diseases for Mature T-Cell and Nk-Cell Neoplasm

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18GeneCards, 19GeneDecks
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Graphical network of diseases related to Mature T-Cell and Nk-Cell Neoplasm:



Diseases related to mature t-cell and nk-cell neoplasm

Symptoms for Mature T-Cell and Nk-Cell Neoplasm

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Drugs & Therapeutics for Mature T-Cell and Nk-Cell Neoplasm

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mature T-Cell and Nk-Cell Neoplasm

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Anatomical Context for Mature T-Cell and Nk-Cell Neoplasm

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34MalaCards
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MalaCards organs/tissues related to Mature T-Cell and Nk-Cell Neoplasm:

34
T cells, Nk cells

Animal Models for Mature T-Cell and Nk-Cell Neoplasm or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Mature T-Cell and Nk-Cell Neoplasm:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.1CDKN1B, PTEN
2MP:00011868.8CDKN1B, PTEN

Publications for Mature T-Cell and Nk-Cell Neoplasm

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53PubMed
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Articles related to Mature T-Cell and Nk-Cell Neoplasm:

idTitleAuthorsYear
1
Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma). (21480860)
2011
2
PTEN and p27 expression in mature T-cell and NK-cell neoplasms. (16194892)
2005

Variations for Mature T-Cell and Nk-Cell Neoplasm

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Expression for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

Search GEO for disease gene expression data for Mature T-Cell and Nk-Cell Neoplasm.

Pathways for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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Sources:
51PathCards, 31KEGG, 54QIAGEN, 39NCBI BioSystems Database, 56Reactome, 55R&D Systems, 61Thomson Reuters, 13EMD Millipore
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Pathways related to Mature T-Cell and Nk-Cell Neoplasm according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CDKN1B, PTEN
2
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
9.1CDKN1B, PTEN
3
Show member pathways
9.1PTEN, CDKN1B
4
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.1CDKN1B, PTEN
59.1PTEN, CDKN1B
6
Show member pathways
9.1CDKN1B, PTEN
7
Show member pathways
9.1CDKN1B, PTEN
8
Show member pathways
9.1CDKN1B, PTEN
9
Show member pathways
9.1PTEN, CDKN1B
109.1CDKN1B, PTEN
11
Show member pathways
9.1CDKN1B, PTEN
129.1PTEN, CDKN1B
139.1CDKN1B, PTEN
14
Show member pathways
DNA damage response39
9.1CDKN1B, PTEN
159.1PTEN, CDKN1B
169.1CDKN1B, PTEN
179.1PTEN, CDKN1B
18
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.1CDKN1B, PTEN
19
Show member pathways
Signaling Pathways in Glioblastoma39
9.1CDKN1B, PTEN
20
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.1CDKN1B, PTEN
21
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.1PTEN, CDKN1B
22
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
9.1CDKN1B, PTEN
239.1CDKN1B, PTEN

Compounds for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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46Novoseek, 62Tocris Bioscience, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Mature T-Cell and Nk-Cell Neoplasm according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1eb 108946 6210.6CDKN1B, PTEN
2cetuximab46 52 1211.6CDKN1B, PTEN
3ciglitazone46 3010.6PTEN, CDKN1B
4indole-3-carbinol469.6CDKN1B, PTEN
5erlotinib46 52 1211.6CDKN1B, PTEN
6trastuzumab46 52 1211.6PTEN, CDKN1B
7bortezomib46 52 1211.6CDKN1B, PTEN
8gefitinib46 52 1211.6CDKN1B, PTEN
9gemcitabine46 52 1211.5PTEN, CDKN1B
10lovastatin46 52 62 30 1213.5CDKN1B, PTEN
11troglitazone46 30 62 1212.5CDKN1B, PTEN
12mg 13246 6210.5PTEN, CDKN1B
13tgf beta1469.5CDKN1B, PTEN
14imatinib46 52 1211.5CDKN1B, PTEN
15cyclophosphamide46 52 1211.5PTEN, CDKN1B
16ceramide469.5CDKN1B, PTEN
17calcitriol46 62 25 1212.5CDKN1B, PTEN
185fluorouracil469.5PTEN, CDKN1B
19agar469.5CDKN1B, PTEN
20etoposide46 52 62 1212.5CDKN1B, PTEN
21tamoxifen46 52 30 1212.5PTEN, CDKN1B
22methionine469.5CDKN1B, PTEN
23paclitaxel46 52 1211.5PTEN, CDKN1B
24rapamycin469.5CDKN1B, PTEN
25pd 98,059469.5CDKN1B, PTEN
26ly294002469.5PTEN, CDKN1B
27wortmannin469.5CDKN1B, PTEN
28doxorubicin46 52 1211.5CDKN1B, PTEN
29glycogen46 2510.4PTEN, CDKN1B
30estradiol46 25 1211.4CDKN1B, PTEN
31phosphoinositide469.4CDKN1B, PTEN
32paraffin469.4PTEN, CDKN1B
33genistein46 30 62 3 25 1214.4CDKN1B, PTEN
34pge2469.4PTEN, CDKN1B
35fatty acid469.4CDKN1B, PTEN
36cisplatin46 52 62 1212.4CDKN1B, PTEN
37leucine469.3PTEN, CDKN1B
38cyclic amp46 2510.3CDKN1B, PTEN
39cycloheximide469.3CDKN1B, PTEN
40progesterone46 30 62 25 1213.2PTEN, CDKN1B
41h2o2469.2CDKN1B, PTEN
42magnesium46 25 1211.1CDKN1B, PTEN
43oligonucleotide469.1CDKN1B, PTEN
44testosterone46 62 25 1212.0PTEN, CDKN1B
45cholesterol46 30 25 1211.8CDKN1B, PTEN

GO Terms for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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17Gene Ontology
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Biological processes related to Mature T-Cell and Nk-Cell Neoplasm according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.4CDKN1B, PTEN
2response to glucoseGO:0097499.4CDKN1B, PTEN
3response to estradiolGO:0323559.4CDKN1B, PTEN
4phosphatidylinositol-mediated signalingGO:0480159.4PTEN, CDKN1B
5fibroblast growth factor receptor signaling pathwayGO:0085439.3CDKN1B, PTEN
6Fc-epsilon receptor signaling pathwayGO:0380959.3CDKN1B, PTEN
7epidermal growth factor receptor signaling pathwayGO:0071739.3PTEN, CDKN1B
8neurotrophin TRK receptor signaling pathwayGO:0480119.2CDKN1B, PTEN
9response to drugGO:0424939.2CDKN1B, PTEN
10negative regulation of cell proliferationGO:0082859.1PTEN, CDKN1B
11innate immune responseGO:0450879.1CDKN1B, PTEN
12positive regulation of cell proliferationGO:0082849.0CDKN1B, PTEN
13negative regulation of apoptotic processGO:0430668.8CDKN1B, PTEN

Products for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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Sources for Mature T-Cell and Nk-Cell Neoplasm

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet