MCID: MTR009
MIFTS: 25

Mature T-Cell and Nk-Cell Neoplasm malady

Cancer diseases category

Summaries for Mature T-Cell and Nk-Cell Neoplasm

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32MalaCards
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MalaCards: Mature T-Cell and Nk-Cell Neoplasm is related to anaplastic large cell lymphoma and cutaneous t cell lymphoma. An important gene associated with Mature T-Cell and Nk-Cell Neoplasm is CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)), and among its related pathways are Focal Adhesion and Toll-like receptor signaling pathway. The compounds etoposide and eb 1089 have been mentioned in the context of this disorder. Affiliated tissues include t cells and nk cells, and related mouse phenotype pigmentation.

Aliases & Classifications for Mature T-Cell and Nk-Cell Neoplasm

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8Disease Ontology
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mature t-cell and nk-cell neoplasm 8


External Ids:

Disease Ontology8 DOID:0050743

Related Diseases for Mature T-Cell and Nk-Cell Neoplasm

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Mature T-Cell and Nk-Cell Neoplasm:



Diseases related to mature t-cell and nk-cell neoplasm

Clinical Features for Mature T-Cell and Nk-Cell Neoplasm

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Drugs & Therapeutics for Mature T-Cell and Nk-Cell Neoplasm

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Mature T-Cell and Nk-Cell Neoplasm

Genetic Tests for Mature T-Cell and Nk-Cell Neoplasm

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Anatomical Context for Mature T-Cell and Nk-Cell Neoplasm

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32MalaCards
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MalaCards organs/tissues related to Mature T-Cell and Nk-Cell Neoplasm:

32
T cells, Nk cells

Animal Models for Mature T-Cell and Nk-Cell Neoplasm or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mature T-Cell and Nk-Cell Neoplasm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.1PTEN, CDKN1B

Publications for Mature T-Cell and Nk-Cell Neoplasm

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50PubMed
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Articles related to Mature T-Cell and Nk-Cell Neoplasm:

idTitleAuthorsYear
1
Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma). (21480860)
2011
2
PTEN and p27 expression in mature T-cell and NK-cell neoplasms. (16194892)
2005

Genetic Variations for Mature T-Cell and Nk-Cell Neoplasm

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Expression for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

Search GEO for disease gene expression data for Mature T-Cell and Nk-Cell Neoplasm.

Pathways for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore, 52R&D Systems
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Pathways related to Mature T-Cell and Nk-Cell Neoplasm according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1PTEN, CDKN1B
2
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9.1CDKN1B, PTEN
3
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9.1PTEN, CDKN1B
4
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9.1PTEN, CDKN1B
5
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9.1CDKN1B, PTEN
69.1CDKN1B, PTEN
7
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9.1PTEN, CDKN1B
89.1PTEN, CDKN1B
99.1PTEN, CDKN1B
109.1CDKN1B, PTEN
11
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9.1PTEN, CDKN1B
129.1PTEN, CDKN1B
13
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9.1CDKN1B, PTEN
149.1PTEN, CDKN1B
15
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9.1PTEN, CDKN1B
169.1CDKN1B, PTEN
17
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9.1CDKN1B, PTEN
18
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9.1PTEN, CDKN1B
199.1PTEN, CDKN1B
209.1PTEN, CDKN1B

Compounds for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Mature T-Cell and Nk-Cell Neoplasm according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1etoposide44 49 59 1113.0CDKN1B
2eb 108944 5910.5PTEN, CDKN1B
3cetuximab44 49 1111.5PTEN, CDKN1B
4ciglitazone44 2810.5PTEN, CDKN1B
5indole-3-carbinol449.5PTEN, CDKN1B
6erlotinib44 49 1111.5CDKN1B, PTEN
7trastuzumab44 49 1111.5PTEN, CDKN1B
8bortezomib44 1110.5PTEN, CDKN1B
9gefitinib44 49 1111.5PTEN, CDKN1B
10gemcitabine44 49 1111.5CDKN1B, PTEN
11lovastatin44 49 59 28 1113.5PTEN, CDKN1B
12troglitazone44 28 59 1112.5PTEN, CDKN1B
13mg 13244 5910.5PTEN, CDKN1B
14tgf beta1449.5CDKN1B, PTEN
15cyclophosphamide44 49 1111.5PTEN, CDKN1B
16imatinib44 49 1111.5PTEN, CDKN1B
17ceramide449.5PTEN, CDKN1B
18calcitriol44 59 11 2412.5CDKN1B, PTEN
19agar449.4PTEN, CDKN1B
20tamoxifen44 49 28 1112.4PTEN, CDKN1B
21methionine449.4PTEN, CDKN1B
22paclitaxel44 49 1111.4CDKN1B, PTEN
23rapamycin449.4PTEN, CDKN1B
24pd 98,059449.4PTEN, CDKN1B
25ly294002449.4PTEN, CDKN1B
26wortmannin449.3CDKN1B, PTEN
27doxorubicin44 49 1111.3PTEN, CDKN1B
28glycogen44 2410.3PTEN, CDKN1B
29estradiol44 11 2411.2PTEN, CDKN1B
30phosphoinositide449.2CDKN1B, PTEN
31paraffin449.1PTEN, CDKN1B
32fatty acid449.1PTEN, CDKN1B
33genistein44 28 59 2 11 2414.0PTEN, CDKN1B
34pge2448.8PTEN, CDKN1B

GO Terms for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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16Gene Ontology
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Biological processes related to Mature T-Cell and Nk-Cell Neoplasm according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.3PTEN, CDKN1B
2phosphatidylinositol-mediated signalingGO:0480159.3PTEN, CDKN1B
3fibroblast growth factor receptor signaling pathwayGO:0085439.2PTEN, CDKN1B
4Fc-epsilon receptor signaling pathwayGO:0380959.2PTEN, CDKN1B
5epidermal growth factor receptor signaling pathwayGO:0071739.1CDKN1B, PTEN
6positive regulation of cell proliferationGO:0082849.1PTEN, CDKN1B
7neurotrophin TRK receptor signaling pathwayGO:0480119.0PTEN, CDKN1B
8negative regulation of cell proliferationGO:0082858.8PTEN, CDKN1B

Products for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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Sources for Mature T-Cell and Nk-Cell Neoplasm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet