MCID: MTR009
MIFTS: 29

Mature T-Cell and Nk-Cell Neoplasm malady

Cancer diseases category
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Summaries for Mature T-Cell and Nk-Cell Neoplasm

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33MalaCards
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MalaCards: Mature T-Cell and Nk-Cell Neoplasm is related to anaplastic large cell lymphoma and cutaneous t cell lymphoma. An important gene associated with Mature T-Cell and Nk-Cell Neoplasm is CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)), and among its related pathways are MicroRNAs in cancer and Focal adhesion. The compounds eb 1089 and cetuximab have been mentioned in the context of this disorder. Affiliated tissues include t cells and nk cells, and related mouse phenotypes are adipose tissue and pigmentation.

Aliases & Classifications for Mature T-Cell and Nk-Cell Neoplasm

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8Disease Ontology
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mature t-cell and nk-cell neoplasm 8


External Ids:

Disease Ontology8 DOID:0050743

Related Diseases for Mature T-Cell and Nk-Cell Neoplasm

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Mature T-Cell and Nk-Cell Neoplasm:



Diseases related to mature t-cell and nk-cell neoplasm

Symptoms for Mature T-Cell and Nk-Cell Neoplasm

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Drugs & Therapeutics for Mature T-Cell and Nk-Cell Neoplasm

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Mature T-Cell and Nk-Cell Neoplasm

Search NIH Clinical Center for Mature T-Cell and Nk-Cell Neoplasm

Genetic Tests for Mature T-Cell and Nk-Cell Neoplasm

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Anatomical Context for Mature T-Cell and Nk-Cell Neoplasm

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33MalaCards
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MalaCards organs/tissues related to Mature T-Cell and Nk-Cell Neoplasm:

33
T cells, Nk cells

Animal Models for Mature T-Cell and Nk-Cell Neoplasm or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Mature T-Cell and Nk-Cell Neoplasm:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.1CDKN1B, PTEN
2MP:00011868.8CDKN1B, PTEN

Publications for Mature T-Cell and Nk-Cell Neoplasm

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52PubMed
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Articles related to Mature T-Cell and Nk-Cell Neoplasm:

idTitleAuthorsYear
1
Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma). (21480860)
2011
2
PTEN and p27 expression in mature T-cell and NK-cell neoplasms. (16194892)
2005

Variations for Mature T-Cell and Nk-Cell Neoplasm

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Expression for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

Search GEO for disease gene expression data for Mature T-Cell and Nk-Cell Neoplasm.

Pathways for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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50PathCards, 30KEGG, 53QIAGEN, 38NCBI BioSystems Database, 55Reactome, 54R&D Systems, 60Thomson Reuters, 12EMD Millipore
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Pathways related to Mature T-Cell and Nk-Cell Neoplasm according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CDKN1B, PTEN
2
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
9.1CDKN1B, PTEN
3
Show member pathways
9.1PTEN, CDKN1B
4
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1CDKN1B, PTEN
59.1PTEN, CDKN1B
6
Show member pathways
9.1CDKN1B, PTEN
7
Show member pathways
9.1CDKN1B, PTEN
8
Show member pathways
9.1CDKN1B, PTEN
9
Show member pathways
9.1PTEN, CDKN1B
109.1CDKN1B, PTEN
11
Show member pathways
9.1CDKN1B, PTEN
129.1PTEN, CDKN1B
139.1CDKN1B, PTEN
14
Show member pathways
DNA damage response38
9.1CDKN1B, PTEN
159.1PTEN, CDKN1B
169.1CDKN1B, PTEN
179.1PTEN, CDKN1B
18
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.1CDKN1B, PTEN
19
Show member pathways
Signaling Pathways in Glioblastoma38
9.1CDKN1B, PTEN
20
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.1CDKN1B, PTEN
21
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.1PTEN, CDKN1B
22
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.1CDKN1B, PTEN
239.1CDKN1B, PTEN

Compounds for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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45Novoseek, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Mature T-Cell and Nk-Cell Neoplasm according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1eb 108945 6110.6CDKN1B, PTEN
2cetuximab45 51 1111.6CDKN1B, PTEN
3ciglitazone45 2910.6PTEN, CDKN1B
4indole-3-carbinol459.6CDKN1B, PTEN
5erlotinib45 51 1111.6CDKN1B, PTEN
6trastuzumab45 51 1111.6PTEN, CDKN1B
7bortezomib45 51 1111.6CDKN1B, PTEN
8gefitinib45 51 1111.6CDKN1B, PTEN
9gemcitabine45 51 1111.5PTEN, CDKN1B
10lovastatin45 51 61 29 1113.5CDKN1B, PTEN
11troglitazone45 29 61 1112.5CDKN1B, PTEN
12mg 13245 6110.5PTEN, CDKN1B
13tgf beta1459.5CDKN1B, PTEN
14imatinib45 51 1111.5CDKN1B, PTEN
15cyclophosphamide45 51 1111.5PTEN, CDKN1B
16ceramide459.5CDKN1B, PTEN
17calcitriol45 61 24 1112.5CDKN1B, PTEN
185fluorouracil459.5PTEN, CDKN1B
19agar459.5CDKN1B, PTEN
20etoposide45 51 61 1112.5CDKN1B, PTEN
21tamoxifen45 51 29 1112.5PTEN, CDKN1B
22methionine459.5CDKN1B, PTEN
23paclitaxel45 51 1111.5PTEN, CDKN1B
24rapamycin459.5CDKN1B, PTEN
25pd 98,059459.5CDKN1B, PTEN
26ly294002459.5PTEN, CDKN1B
27wortmannin459.5CDKN1B, PTEN
28doxorubicin45 51 1111.5CDKN1B, PTEN
29glycogen45 2410.4PTEN, CDKN1B
30estradiol45 24 1111.4CDKN1B, PTEN
31phosphoinositide459.4CDKN1B, PTEN
32paraffin459.4PTEN, CDKN1B
33genistein45 29 61 3 24 1114.4CDKN1B, PTEN
34pge2459.4PTEN, CDKN1B
35fatty acid459.4CDKN1B, PTEN
36cisplatin45 51 61 1112.4CDKN1B, PTEN
37leucine459.3PTEN, CDKN1B
38cyclic amp45 2410.3CDKN1B, PTEN
39cycloheximide459.3CDKN1B, PTEN
40progesterone45 29 61 24 1113.2PTEN, CDKN1B
41h2o2459.2CDKN1B, PTEN
42magnesium45 24 1111.1CDKN1B, PTEN
43oligonucleotide459.1CDKN1B, PTEN
44testosterone45 61 24 1112.0PTEN, CDKN1B
45cholesterol45 29 24 1111.8CDKN1B, PTEN

GO Terms for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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16Gene Ontology
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Biological processes related to Mature T-Cell and Nk-Cell Neoplasm according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.4CDKN1B, PTEN
2response to glucoseGO:0097499.4CDKN1B, PTEN
3response to estradiolGO:0323559.4CDKN1B, PTEN
4phosphatidylinositol-mediated signalingGO:0480159.4PTEN, CDKN1B
5fibroblast growth factor receptor signaling pathwayGO:0085439.3CDKN1B, PTEN
6Fc-epsilon receptor signaling pathwayGO:0380959.3CDKN1B, PTEN
7epidermal growth factor receptor signaling pathwayGO:0071739.3PTEN, CDKN1B
8neurotrophin TRK receptor signaling pathwayGO:0480119.2CDKN1B, PTEN
9response to drugGO:0424939.2CDKN1B, PTEN
10negative regulation of cell proliferationGO:0082859.1PTEN, CDKN1B
11innate immune responseGO:0450879.1CDKN1B, PTEN
12positive regulation of cell proliferationGO:0082849.0CDKN1B, PTEN
13negative regulation of apoptotic processGO:0430668.8CDKN1B, PTEN

Products for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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Sources for Mature T-Cell and Nk-Cell Neoplasm

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet