MCID: MTR009
MIFTS: 16

Mature T-Cell and Nk-Cell Neoplasm malady

Summaries for Mature T-Cell and Nk-Cell Neoplasm

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33MalaCards
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MalaCards: Mature T-Cell and Nk-Cell Neoplasm is related to anaplastic large cell lymphoma and renal clear cell carcinoma. An important gene associated with Mature T-Cell and Nk-Cell Neoplasm is CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)), and among its related pathways are Focal Adhesion and Toll-like receptor signaling pathway. The compounds etoposide and eb 1089 have been mentioned in the context of this disorder. Related mouse phenotype pigmentation.

Aliases & Classifications for Mature T-Cell and Nk-Cell Neoplasm

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8Disease Ontology
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Aliases & Descriptions:

mature t-cell and nk-cell neoplasm 8


External Ids:

Disease Ontology8 DOID:0050743

Related Diseases for Mature T-Cell and Nk-Cell Neoplasm

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Mature T-Cell and Nk-Cell Neoplasm:



Diseases related to mature t-cell and nk-cell neoplasm

Clinical Features for Mature T-Cell and Nk-Cell Neoplasm

Drugs & Therapeutics for Mature T-Cell and Nk-Cell Neoplasm

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mature T-Cell and Nk-Cell Neoplasm

Anatomical Context for Mature T-Cell and Nk-Cell Neoplasm

Animal Models for Mature T-Cell and Nk-Cell Neoplasm or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Mature T-Cell and Nk-Cell Neoplasm:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.1PTEN, CDKN1B

Publications for Mature T-Cell and Nk-Cell Neoplasm

Genetic Variations for Mature T-Cell and Nk-Cell Neoplasm

Expression for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

Search GEO for disease gene expression data for Mature T-Cell and Nk-Cell Neoplasm.

Pathways for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

Sources:
38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 54Reactome, 12EMD Millipore, 53R&D Systems
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Pathways related to Mature T-Cell and Nk-Cell Neoplasm according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1PTEN, CDKN1B
2
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9.1PTEN, CDKN1B
3
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9.1PTEN, CDKN1B
4
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9.1PTEN, CDKN1B
5
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9.1CDKN1B, PTEN
69.1CDKN1B, PTEN
7
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9.1CDKN1B, PTEN
89.1PTEN, CDKN1B
99.1CDKN1B, PTEN
109.1PTEN, CDKN1B
11
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9.1CDKN1B, PTEN
129.1CDKN1B, PTEN
13
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9.1CDKN1B, PTEN
149.1CDKN1B, PTEN
15
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9.1PTEN, CDKN1B
169.1CDKN1B, PTEN
17
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9.1PTEN, CDKN1B
18
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9.1PTEN, CDKN1B
199.1CDKN1B, PTEN
209.1CDKN1B, PTEN

Compounds for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Mature T-Cell and Nk-Cell Neoplasm according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1etoposide45 50 60 1113.0CDKN1B
2eb 108945 6010.5PTEN, CDKN1B
3cetuximab45 50 1111.5PTEN, CDKN1B
4ciglitazone45 2910.5PTEN, CDKN1B
5indole-3-carbinol459.5PTEN, CDKN1B
6erlotinib45 50 1111.5CDKN1B, PTEN
7trastuzumab45 50 1111.5CDKN1B, PTEN
8bortezomib45 1110.5PTEN, CDKN1B
9gefitinib45 50 1111.5PTEN, CDKN1B
10gemcitabine45 50 1111.5CDKN1B, PTEN
11lovastatin45 50 60 29 1113.5PTEN, CDKN1B
12troglitazone45 29 60 1112.5CDKN1B, PTEN
13mg 13245 6010.5PTEN, CDKN1B
14tgf beta1459.5PTEN, CDKN1B
15cyclophosphamide45 50 1111.5CDKN1B, PTEN
16imatinib45 50 1111.5CDKN1B, PTEN
17ceramide459.5PTEN, CDKN1B
18calcitriol45 60 11 2412.5PTEN, CDKN1B
19agar459.4PTEN, CDKN1B
20tamoxifen45 50 29 1112.4PTEN, CDKN1B
21methionine459.4CDKN1B, PTEN
22paclitaxel45 50 1111.4PTEN, CDKN1B
23rapamycin459.4CDKN1B, PTEN
24pd 98,059459.4CDKN1B, PTEN
25ly294002459.4CDKN1B, PTEN
26wortmannin459.3CDKN1B, PTEN
27doxorubicin45 50 1111.3PTEN, CDKN1B
28glycogen45 2410.3CDKN1B, PTEN
29estradiol45 11 2411.2PTEN, CDKN1B
30phosphoinositide459.2PTEN, CDKN1B
31paraffin459.1PTEN, CDKN1B
32fatty acid459.1PTEN, CDKN1B
33genistein45 29 60 2 11 2414.0PTEN, CDKN1B
34pge2458.8CDKN1B, PTEN

GO Terms for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

Sources:
16Gene Ontology
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Biological processes related to Mature T-Cell and Nk-Cell Neoplasm according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.3PTEN, CDKN1B
2phosphatidylinositol-mediated signalingGO:0480159.3PTEN, CDKN1B
3fibroblast growth factor receptor signaling pathwayGO:0085439.2PTEN, CDKN1B
4Fc-epsilon receptor signaling pathwayGO:0380959.2CDKN1B, PTEN
5epidermal growth factor receptor signaling pathwayGO:0071739.1CDKN1B, PTEN
6positive regulation of cell proliferationGO:0082849.1CDKN1B, PTEN
7neurotrophin TRK receptor signaling pathwayGO:0480119.0PTEN, CDKN1B
8negative regulation of cell proliferationGO:0082858.8CDKN1B, PTEN

Products for genes affiliated with Mature T-Cell and Nk-Cell Neoplasm

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Sources for Mature T-Cell and Nk-Cell Neoplasm

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet