Maturity-onset Diabetes of the Young, Type 2 malady

MalaCards: Maturity-onset Diabetes of the Young, Type 2, also known as type 2 maturity-onset diabetes of the young, is related to maturity-onset diabetes of the young and thyroiditis. An important gene associated with Maturity-onset Diabetes of the Young, Type 2 is GCK (glucokinase (hexokinase 4)), and among its related pathways are Regulation of Signaling by NODAL and Development_Role of Activin A in cell differentiation and proliferation. The drugs glipizide and chromium picolinate and the compounds manganese and magnesium have been mentioned in the context of this disorder. Affiliated tissues include b cells.

OMIM: 125851

maturity-onset diabetes of the young, type 2 30 type 2 maturity-onset diabetes of the young 30 16 diabetes mellitus mody type 2 30 16 mody2 30 16 maturity-onset diabetes of the young, type 2 (disorder) 43

diabetes mellitus, non-insulin-dependent 43 mody glucokinase-related 30 diabetes mellitus 43 mody, type ii 33 mody type 2 30

Disease types for maturity-onset diabetes of the young family:

maturity-onset diabetes of the young, type 1	maturity-onset diabetes of the young, type 2
maturity-onset diabetes of the young, type 3	maturity-onset diabetes of the young, type 4
maturity-onset diabetes of the young, type 5	maturity-onset diabetes of the young, type 6
maturity-onset diabetes of the young, type 7	maturity-onset diabetes of the young, type 8
maturity-onset diabetes of the young, type 9	maturity-onset diabetes of the young, type 11
maturity-onset diabetes of the young, type 10

Diseases related to maturity-onset diabetes of the young, type 2 by text searches and GeneDecks gene sharing:

(show top 50)    (show all 373)

id	Related Disease	Score	Top Affiliating Genes
1	maturity-onset diabetes of the young	35.2	GCK, ACVR2B, ACVR2A
2	thyroiditis	32.9	GCK, ACVR2B, ACVR2A
3	pancreatic cancer	27.5	ACVR2A, ACVR2B, GCK
4	adenoma	25.2	GCK, ACVR2B, ACVR2A
5	insulin resistance	12.6
6	goiter	12.3	ACVR2B, ACVR2A
7	secondary hyperparathyroidism of renal origin	12.2	ACVR2B, ACVR2A
8	hypertension	12.2
9	hyperparathyroidism	12.2	ACVR2B, ACVR2A
10	pre-eclampsia	12.1	ACVR2B, ACVR2A
11	pheochromocytoma	12.0	ACVR2A, ACVR2B
12	eclampsia	11.8	ACVR2A, ACVR2B
13	pituitary adenoma	11.7	ACVR2A, ACVR2B, GCK
14	maturity-onset diabetes of the young, type 3	10.7
15	maturity-onset diabetes of the young, type 5	10.7
16	atherosclerosis	10.6
17	maturity-onset diabetes of the young, type 1	10.5
18	maturity-onset diabetes of the young, type 8	10.5
19	coronary heart disease	10.4
20	maturity-onset diabetes of the young, type 9	10.3
21	maturity-onset diabetes of the young, type 6	10.3
22	maturity-onset diabetes of the young, type 7	10.3
23	diabetic retinopathy	10.3
24	neuropathy	10.3
25	hyperglycemia	10.3
26	permanent neonatal diabetes mellitus	10.0
27	blindness	9.9
28	cholesterol	9.8
29	retinol binding protein	9.7
30	homocysteine	9.7
31	maturity-onset diabetes of the young, type 4	9.6
32	diabetes mellitus, 6q24-related transient neonatal	9.6
33	myocardial infarction	9.4
34	proteinuria	9.4
35	celiac disease	9.3
36	autonomic neuropathy	9.2
37	maturity-onset diabetes of the young, type 11	9.1
38	maturity-onset diabetes of the young, type 10	9.1
39	maturity-onset diabetes of the young type10	9.1
40	vascular disease	9.1
41	diabetes mellitus	9.1
42	wolfram syndrome	9.0
43	autoimmune thyroiditis	8.9
44	hyperlipidemia	8.9
45	alcoholism	8.7
46	diabetic neuropathy	8.7
47	essential hypertension	8.7
48	dementia	8.6
49	glucose intolerance	8.6
50	polyneuropathy	8.6

Clinical features from OMIM: 125851

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acarbose, acetohexamide, chlorpropamide, chromium picolinate, exenatide, glimepiride, glipizide, glyburide, insulin, insulin,aspart protamine, insulin,aspart,human/rdna, insulin,detemir,human, insulin,glargine,human/rdna, insulin,glulisine,human, insulin,lente,beef, insulin,lente,beef/pork, insulin,lente,beef/purified, insulin,lente,human/rdna, insulin,lente,human/semisynthetic, insulin,lente,pork/purified, insulin,lispro,human/rdna, insulin,lispro,protamine/rdna, insulin,nph,beef, insulin,nph,beef/pork, insulin,nph,beef/purified, insulin,nph,human/rdna, insulin,nph,human/semisynthetic, insulin,nph,pork/purified, insulin,protamine zinc,beef/pork, insulin,protamine zinc,beef/purified, insulin,protamine zinc,pork/purified, insulin,regular,beef/pork, insulin,regular,beef/purified, insulin,regular,human buffered, insulin,regular,human/rdna, insulin,regular,human/semisynthetic, insulin,regular,pork, insulin,regular,pork/purified, insulin,semilente,beef, insulin,semilente,beef/pork, insulin,semilente,pork/purified, insulin,ultralente,beef, insulin,ultralente,beef/pork, insulin,ultralente,beef/purified, insulin,ultralente,human, insulin,ultralente,human/rdna, metformin, metformin hydrochloride, miglitol, nateglinide, pioglitazone, pioglitazone hcl, pioglitazone hydrochloride, pramlintide, repaglinide, rosiglitazone, rosiglitazone maleate, sitagliptin, sitagliptin phosphate, tolazamide, tolbutamide, tolbutamide sodium, troglitazone

Genetic tests related to maturity-onset diabetes of the young, type 2:

id	Genetic test	Affiliating Genes
1	Maturity-onset Diabetes Of The Young, Type 2 clinical/research	GCK

MalaCards organs/tissues related to maturity-onset diabetes of the young, type 2:

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Articles related to maturity-onset diabetes of the young, type 2:

id	Title	Authors	Year	Affiliating Genes
1	Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MOD Y 2). (19952346)	van BA1rck L.... Herbach N.	2010	GCK
2	A novel glucokinase gene mutation and its effect on g lycemic/C-peptide fluctuations in a patient with maturity-onset diabetes of the young type 2. (20015564)	Loomba-Albrecht L.A.... Bremer A.A.	2010	GCK
3	A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. (15102714)	Inoue M.... Noda T.	2004	GCK
4	No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. (11334431)	Dupont S.... Froguel P.	2001	ACVR2B, ACVR2A
5	Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype. (10426385)	Miller S.P.... Lange A.J.	1999	GCK
6	Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinaemia (GK-HI). (10455021)	Burke C.V.... Raper S.E.	1999	GCK
7	Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2). (9078243)	Kesavan P.... Matschinsky F.M.	1997	GCK

Genes related to maturity-onset diabetes of the young, type 2 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	GCK	glucokinase (hexokinase 4)	11.1	Publications, Summaries
2	ACVR2B	activin A receptor, type IIB	11.0	Publications
3	ACVR2A	activin A receptor, type IIA	11.0	Publications

Pathways related to maturity-onset diabetes of the young, type 2 according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Regulation of Signaling by NODAL38	9.3	ACVR2A, ACVR2B
2	Development_Role of Activin A in cell differentiation and proliferation41	9.2	ACVR2A, ACVR2B
3	Development Role of Activin A in cell differentiation and proliferation10	9.2	ACVR2A, ACVR2B
4	Signal transduction_Activin A signaling regulation41	9.1	ACVR2B, ACVR2A
5	Cytokine-cytokine receptor interaction20	9.1	ACVR2A, ACVR2B
6	Signal transduction Activin A signaling regulation10	9.0	ACVR2B, ACVR2A
7	TGF-beta signaling pathway20	8.8	ACVR2B, ACVR2A

Compounds related to maturity-onset diabetes of the young, type 2 according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	manganese32 18	9.8	ACVR2B, ACVR2A
2	magnesium32 9 18 9	11.6	ACVR2B, GCK, ACVR2A
3	threonine32	8.6	ACVR2A, ACVR2B, GCK
4	adp32 18	9.5	GCK, ACVR2B, ACVR2A
5	serine32	8.5	ACVR2A, ACVR2B, GCK
6	Adenosine triphosphate9 18 9	10.4	GCK, ACVR2B, ACVR2A

Cellular components related to maturity-onset diabetes of the young, type 2 according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:009986	9.1	ACVR2B, ACVR2A

Biological processes related to maturity-onset diabetes of the young, type 2 according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of activin receptor signaling pathway	GO:032927	9.3	ACVR2B, ACVR2A
2	transmembrane receptor protein serine/threonine kinase signaling pathway	GO:007178	9.3	ACVR2B, ACVR2A
3	gastrulation with mouth forming second	GO:001702	9.3	ACVR2B, ACVR2A
4	mesoderm development	GO:007498	9.2	ACVR2A, ACVR2B
5	positive regulation of bone mineralization	GO:030501	9.2	ACVR2B, ACVR2A
6	determination of left/right symmetry	GO:007368	9.1	ACVR2A, ACVR2B
7	anterior/posterior pattern specification	GO:009952	9.1	ACVR2B, ACVR2A
8	positive regulation of osteoblast differentiation	GO:045669	9.0	ACVR2B, ACVR2A
9	BMP signaling pathway	GO:030509	8.8	ACVR2A, ACVR2B

Molecular functions related to maturity-onset diabetes of the young, type 2 according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	activin receptor activity, type II	GO:016362	9.2	ACVR2A, ACVR2B
2	receptor signaling protein serine/threonine kinase activity	GO:004702	9.2	ACVR2B, ACVR2A
3	activin binding	GO:048185	9.1	ACVR2B, ACVR2A
4	transforming growth factor beta-activated receptor activity	GO:005024	9.0	ACVR2A, ACVR2B
5	growth factor binding	GO:019838	8.8	ACVR2B, ACVR2A
6	ATP binding	GO:005524	8.5	ACVR2B, GCK, ACVR2A