MCID: MTR019
MIFTS: 30

Maturity-Onset Diabetes of the Young, Type 2 malady

Summaries for Maturity-Onset Diabetes of the Young, Type 2

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33MalaCards
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MalaCards: Maturity-Onset Diabetes of the Young, Type 2, also known as diabetes mellitus, non-insulin-dependent, is related to maturity-onset diabetes of the young and type 2 diabetes mellitus. An important gene associated with Maturity-Onset Diabetes of the Young, Type 2 is GCK (glucokinase (hexokinase 4)), and among its related pathways are Signal transduction Activin A signaling regulation and PKA activation in glucagon signalling. The drugs acetohexamide and chlorpropamide and the compounds manganese and magnesium have been mentioned in the context of this disorder.

Aliases & Classifications for Maturity-Onset Diabetes of the Young, Type 2

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43NIH Rare Diseases, 20GeneTests, 22GTR, 61UMLS
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Aliases & Descriptions:

maturity-onset diabetes of the young, type 2 43 20 22 61
diabetes mellitus, non-insulin-dependent 61


Related Diseases for Maturity-Onset Diabetes of the Young, Type 2

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Maturity-Onset Diabetes of the Young, Type 2:



Diseases related to maturity-onset diabetes of the young, type 2

Clinical Features for Maturity-Onset Diabetes of the Young, Type 2

Drugs & Therapeutics for Maturity-Onset Diabetes of the Young, Type 2

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Genetic Tests for Maturity-Onset Diabetes of the Young, Type 2

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20GeneTests, 22GTR
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Genetic tests related to Maturity-Onset Diabetes of the Young, Type 2:

id Genetic test Affiliating Genes
1 Maturity-onset Diabetes Of The Young Type 220 GCK
2 Maturity-onset Diabetes Of The Young, Type 222

Anatomical Context for Maturity-Onset Diabetes of the Young, Type 2

Animal Models for Maturity-Onset Diabetes of the Young, Type 2 or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Maturity-Onset Diabetes of the Young, Type 2

Genetic Variations for Maturity-Onset Diabetes of the Young, Type 2

Expression for genes affiliated with Maturity-Onset Diabetes of the Young, Type 2

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Maturity-Onset Diabetes of the Young, Type 2

Search GEO for disease gene expression data for Maturity-Onset Diabetes of the Young, Type 2.

Pathways for genes affiliated with Maturity-Onset Diabetes of the Young, Type 2

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12EMD Millipore, 54Reactome, 56SinoBiological, 30KEGG
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Compounds for genes affiliated with Maturity-Onset Diabetes of the Young, Type 2

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR
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Compounds related to Maturity-Onset Diabetes of the Young, Type 2 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1manganese45 2410.1ACVR2B, ACVR2A
2magnesium45 11 2410.6GCK, ACVR2B, ACVR2A
3threonine458.6GCK, ACVR2B, ACVR2A
4adp45 29 2410.5ACVR2A, GCK, ACVR2B
5Adenosine triphosphate11 249.4GCK, ACVR2B, ACVR2A
6serine458.2GCK, ACVR2A, ACVR2B

GO Terms for genes affiliated with Maturity-Onset Diabetes of the Young, Type 2

Sources:
16Gene Ontology
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Cellular components related to Maturity-Onset Diabetes of the Young, Type 2 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.1ACVR2A, ACVR2B

Biological processes related to Maturity-Onset Diabetes of the Young, Type 2 according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of activin receptor signaling pathwayGO:0329279.3ACVR2A, ACVR2B
2transmembrane receptor protein serine/threonine kinase signaling pathwayGO:0071789.3ACVR2A, ACVR2B
3gastrulation with mouth forming secondGO:0017029.3ACVR2A, ACVR2B
4positive regulation of bone mineralizationGO:0305019.2ACVR2B, ACVR2A
5mesoderm developmentGO:0074989.2ACVR2B, ACVR2A
6determination of left/right symmetryGO:0073689.1ACVR2A, ACVR2B
7anterior/posterior pattern specificationGO:0099529.1ACVR2A, ACVR2B
8positive regulation of osteoblast differentiationGO:0456699.0ACVR2B, ACVR2A
9BMP signaling pathwayGO:0305098.8ACVR2A, ACVR2B

Molecular functions related to Maturity-Onset Diabetes of the Young, Type 2 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inhibin bindingGO:0347119.2ACVR2A, ACVR2B
2receptor signaling protein serine/threonine kinase activityGO:0047029.2ACVR2A, ACVR2B
3activin bindingGO:0481859.1ACVR2A, ACVR2B
4transforming growth factor beta-activated receptor activityGO:0050249.0ACVR2B, ACVR2A
5growth factor bindingGO:0198388.8ACVR2A, ACVR2B
6ATP bindingGO:0055248.5ACVR2A, ACVR2B, GCK

Products for genes affiliated with Maturity-Onset Diabetes of the Young, Type 2

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Maturity-Onset Diabetes of the Young, Type 2

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet