Maturity-onset Diabetes of the Young, Type 4 malady

MalaCards: Maturity-onset Diabetes of the Young, Type 4, also known as type 4 maturity-onset diabetes of the young, is related to hypertension and maturity-onset diabetes of the young, type 3. An important gene associated with Maturity-onset Diabetes of the Young, Type 4 is PDX1 (pancreatic and duodenal homeobox 1). The drugs glipizide and chromium picolinate have been mentioned in the context of this disorder.

OMIM: 606392

maturity-onset diabetes of the young, type 4 30 type 4 maturity-onset diabetes of the young 30 16 diabetes mellitus mody type 4 30 16 mody4 30 16 maturity-onset diabetes of the young, type iv (disorder) 43

diabetes mellitus, non-insulin-dependent 43 mody insulin promoter factor-1 related 30 diabetes mellitus 43 mody, type iv 33 mody type 4 30

Disease types for maturity-onset diabetes of the young family:

maturity-onset diabetes of the young, type 1	maturity-onset diabetes of the young, type 2
maturity-onset diabetes of the young, type 3	maturity-onset diabetes of the young, type 4
maturity-onset diabetes of the young, type 5	maturity-onset diabetes of the young, type 6
maturity-onset diabetes of the young, type 7	maturity-onset diabetes of the young, type 8
maturity-onset diabetes of the young, type 9	maturity-onset diabetes of the young, type 11
maturity-onset diabetes of the young, type 10

Diseases related to maturity-onset diabetes of the young, type 4 by text searches and GeneDecks gene sharing:

(show top 50)    (show all 307)

id	Related Disease	Score	Top Affiliating Genes
1	hypertension	12.2
2	maturity-onset diabetes of the young, type 3	10.7
3	thyroiditis	10.4
4	diabetic retinopathy	10.3
5	neuropathy	10.3
6	permanent neonatal diabetes mellitus	10.0
7	blindness	9.9
8	homocysteine	9.7
9	diabetes mellitus, 6q24-related transient neonatal	9.6
10	myocardial infarction	9.4
11	proteinuria	9.4
12	celiac disease	9.3
13	autonomic neuropathy	9.2
14	vascular disease	9.1
15	wolfram syndrome	9.0
16	autoimmune thyroiditis	8.9
17	hyperlipidemia	8.9
18	alcoholism	8.7
19	diabetic neuropathy	8.7
20	essential hypertension	8.7
21	dementia	8.6
22	polyneuropathy	8.6
23	retinitis	8.6
24	diabetic polyneuropathy	8.5
25	hypercholesterolemia	8.5
26	hypertriglyceridemia	8.5
27	lipodystrophy	8.5
28	liver disease	8.5
29	abcc8-related transient neonatal diabetes mellitus 2	8.3
30	acromegaly	8.3
31	anemia	8.3
32	arthritis	8.3
33	cerebritis	8.3
34	graves' disease	8.3
35	ischemia	8.3
36	tuberculosis	8.3
37	hepatitis c	8.1
38	ischemic heart disease	8.1
39	lipoatrophic diabetes	8.1
40	metabolic disorders	8.1
41	pulmonary tuberculosis	8.1
42	rheumatoid arthritis	8.1
43	twinning	8.1
44	diabetes mellitus, neonatal, with congenital hypothyroidism	8.1
45	peripheral neuropathy	7.8
46	cerebrovascular disease	7.8
47	diabetes mellitus, insulin-resistant, with acanthosis nigricans	7.8
48	diabetes mellitus, permanent neonatal, with cerebellar agenesis	7.8
49	hemochromatosis	7.8
50	hypogonadism	7.8

Clinical features from OMIM: 606392

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acarbose, acetohexamide, chlorpropamide, chromium picolinate, exenatide, glimepiride, glipizide, glyburide, insulin, insulin,aspart protamine, insulin,aspart,human/rdna, insulin,detemir,human, insulin,glargine,human/rdna, insulin,glulisine,human, insulin,lente,beef, insulin,lente,beef/pork, insulin,lente,beef/purified, insulin,lente,human/rdna, insulin,lente,human/semisynthetic, insulin,lente,pork/purified, insulin,lispro,human/rdna, insulin,lispro,protamine/rdna, insulin,nph,beef, insulin,nph,beef/pork, insulin,nph,beef/purified, insulin,nph,human/rdna, insulin,nph,human/semisynthetic, insulin,nph,pork/purified, insulin,protamine zinc,beef/pork, insulin,protamine zinc,beef/purified, insulin,protamine zinc,pork/purified, insulin,regular,beef/pork, insulin,regular,beef/purified, insulin,regular,human buffered, insulin,regular,human/rdna, insulin,regular,human/semisynthetic, insulin,regular,pork, insulin,regular,pork/purified, insulin,semilente,beef, insulin,semilente,beef/pork, insulin,semilente,pork/purified, insulin,ultralente,beef, insulin,ultralente,beef/pork, insulin,ultralente,beef/purified, insulin,ultralente,human, insulin,ultralente,human/rdna, metformin, metformin hydrochloride, miglitol, nateglinide, pioglitazone, pioglitazone hcl, pioglitazone hydrochloride, pramlintide, repaglinide, rosiglitazone, rosiglitazone maleate, sitagliptin, sitagliptin phosphate, tolazamide, tolbutamide, tolbutamide sodium, troglitazone

Genetic tests related to maturity-onset diabetes of the young, type 4:

id	Genetic test	Affiliating Genes
1	Maturity-onset Diabetes Of The Young, Type 4 clinical/research	PDX1

Genes related to maturity-onset diabetes of the young, type 4 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PDX1	pancreatic and duodenal homeobox 1	11.1	Disorders, Summaries