MCID: MXL015
MIFTS: 39

Maxillary Sinusitis

Categories: Respiratory diseases

Aliases & Classifications for Maxillary Sinusitis

MalaCards integrated aliases for Maxillary Sinusitis:

Name: Maxillary Sinusitis 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2051
ICD10 32 J32.0
MeSH 41 D015523
NCIt 46 C34809
SNOMED-CT 64 275484005 88348008
UMLS 69 C0024959

Summaries for Maxillary Sinusitis

Disease Ontology : 12 A sinusitis which involves infection of maxillary sinuses that causes pain or pressure over the cheeks just below the eyes, tooth ache, and headache.

MalaCards based summary : Maxillary Sinusitis is related to chronic maxillary sinusitis and paranasal sinus disease. An important gene associated with Maxillary Sinusitis is IRAK4 (Interleukin 1 Receptor Associated Kinase 4), and among its related pathways/superpathways are NF-kappaB Signaling and amb2 Integrin signaling. The drugs Estradiol and Ethinyl Estradiol have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and testes.

Related Diseases for Maxillary Sinusitis

Diseases in the Maxillary Sinusitis family:

Chronic Maxillary Sinusitis Acute Maxillary Sinusitis

Diseases related to Maxillary Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 chronic maxillary sinusitis 32.9 CD79A MPO RHNO1 RNASE3
2 paranasal sinus disease 31.2 CD79A RHNO1
3 common cold 29.4 CCL5 RNASE3 SELP
4 bronchitis 29.2 CD79A MPO RNASE3
5 acute maxillary sinusitis 12.6
6 sinusitis 11.6
7 immune-complex glomerulonephritis 10.3 MPO SELP
8 proctitis 10.3 MPO RNASE3
9 churg-strauss syndrome 10.3 MPO RNASE3
10 chronic eosinophilic pneumonia 10.2 CCL5 RNASE3
11 chronic conjunctivitis 10.2 CCL5 RNASE3
12 status asthmaticus 10.2 CCL5 RNASE3
13 kimura disease 10.2 CCL5 RNASE3
14 vernal keratoconjunctivitis 10.2 CCL5 RNASE3
15 chronic rhinitis 10.2 MPO RHNO1
16 pulmonary eosinophilia 10.1 CCL5 RNASE3
17 eosinophilic pneumonia 10.1 CCL5 RNASE3
18 onchocerciasis 10.1 CCL5 RNASE3
19 multiple cranial nerve palsy 10.1 MPO RHNO1
20 ige responsiveness, atopic 10.1 RNASE3 SELP
21 bronchial disease 10.0 CCL5 RNASE3
22 monoclonal paraproteinemia 10.0 CD79A MPO
23 mucositis 10.0
24 headache 10.0
25 rapidly progressive glomerulonephritis 10.0 CD79A MPO
26 goodpasture syndrome 10.0 CD79A MPO
27 acute proliferative glomerulonephritis 10.0 CD79A MPO
28 bronchopneumonia 10.0 CD79A MPO
29 chronic interstitial cystitis 10.0 CD79A RNASE3
30 cow milk allergy 10.0 CD79A RNASE3
31 hypersensitivity vasculitis 10.0 CD79A MPO
32 hypersensitivity reaction type iii disease 10.0 CD79A MPO
33 vulvitis 10.0 CD79A MPO
34 pleuropneumonia 10.0 CD79A IRAK4
35 periodontosis 10.0 CD79A MPO
36 ulcerative stomatitis 10.0 CD79A MPO
37 pulmonary hemosiderosis 10.0 CD79A MPO
38 nasopharyngitis 10.0
39 enophthalmos 10.0
40 odontoma 10.0
41 pollen allergy 10.0 CD79A RNASE3
42 milk allergy 9.9 CD79A RNASE3
43 primary thrombocytopenia 9.9 CD79A SELP
44 orofacial granulomatosis 9.9 CCL5 CD79A
45 shigellosis 9.9 CD79A IRAK4
46 ocular cicatricial pemphigoid 9.9 CD79A RNASE3
47 inclusion conjunctivitis 9.9 CCL5 CD79A
48 herpes gestationis 9.9 CD79A RNASE3
49 osteonecrosis 9.9
50 lymphoma 9.9

Graphical network of the top 20 diseases related to Maxillary Sinusitis:



Diseases related to Maxillary Sinusitis

Symptoms & Phenotypes for Maxillary Sinusitis

Drugs & Therapeutics for Maxillary Sinusitis

Drugs for Maxillary Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
3
Moxifloxacin Approved, Investigational Phase 4,Phase 3 151096-09-2, 354812-41-2 152946
4
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
5
Azithromycin Approved Phase 4,Phase 3 83905-01-5 53477736 447043 55185
6
Clarithromycin Approved Phase 4 81103-11-9 84029
7
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
8
Telithromycin Approved Phase 4,Phase 3 191114-48-4 0 5462516
9 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
10 Anti-Infective Agents Phase 4,Phase 3,Phase 2
11 Contraceptive Agents Phase 4
12 Contraceptives, Oral Phase 4
13 Contraceptives, Oral, Combined Phase 4
14 Estradiol 17 beta-cypionate Phase 4
15 Estradiol 3-benzoate Phase 4
16 Estradiol valerate Phase 4 979-32-8
17 Fluoroquinolones Phase 4
18 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3
19 Nucleic Acid Synthesis Inhibitors Phase 4
20 Polyestradiol phosphate Phase 4
21 Topoisomerase Inhibitors Phase 4,Phase 3
22 Antibiotics, Antitubercular Phase 4
23 Antitubercular Agents Phase 4
24 Cytochrome P-450 CYP3A Inhibitors Phase 4
25 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
26 Erythromycin Estolate Phase 4
27 Erythromycin Ethylsuccinate Phase 4
28 Erythromycin stearate Phase 4
29
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
30
Ofloxacin Approved Phase 3 82419-36-1 4583
31
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
32 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
33 Renal Agents Phase 3
34 Amoxicillin-Potassium Clavulanate Combination Phase 3
35 beta-Lactamase Inhibitors Phase 3
36 Clavulanic Acid Phase 3
37
Ephedrine Approved Phase 2 299-42-3 9294
38
Pseudoephedrine Approved Phase 2 90-82-4 7028
39 Adrenergic Agents Phase 2
40 Anti-Asthmatic Agents Phase 2
41 Autonomic Agents Phase 2
42 Bronchodilator Agents Phase 2
43 Central Nervous System Stimulants Phase 2
44 Nasal Decongestants Phase 2
45 Neurotransmitter Agents Phase 2
46 Peripheral Nervous System Agents Phase 2
47 Respiratory System Agents Phase 2
48 Vasoconstrictor Agents Phase 2
49
Xylometazoline Approved, Investigational 526-36-3 5709

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox Completed NCT00668304 Phase 4 Avelox (Moxifloxacin, BAY12-8039)
2 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
3 Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis Terminated NCT00245440 Phase 4 Azithromycin;Telithromycin
4 A Study Evaluating the Safety and Efficacy of Treating Sinus Infection With Levofloxacin 750 mg for 5 Days. Completed NCT00236652 Phase 3 levofloxacin
5 A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Sinus Infections in Adults Completed NCT00643409 Phase 3 azithromycin SR (Zithromax; compound: CP-62,993);levofloxacin
6 AMS VS MOXI Ketek vs Avelox in AMS Completed NCT00537563 Phase 3 Telithromycin
7 A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses Completed NCT00249210 Phase 3 levofloxacin
8 Preventing Frequent Sinus Infections in HIV-Infected Patients Withdrawn NCT00000752 Phase 2 Pseudoephedrine hydrochloride;Guaifenesin;Cefuroxime axetil;Beclomethasone dipropionate
9 Acute Upper Respiratory Tract Infection - When is Bacteria Involved? Unknown status NCT01580137
10 Non-Interventional Open Label Prospective Comparative Observational Study Of Evaluation Of Compliance In The Empiric Treatment With Azithromycin SR Versus Amoxiclav 1000 Mg In Adult Patients With Of Acute Bacterial Maxillary Sinusitis Completed NCT01032174 Azithromycin SR;Amoxiclav 1000 mg
11 Levofloxacin in Bacterial Rhinosinussitis Completed NCT02712502 Levofloxacin;Amoxicillin-Potassium Clavulanate Combination
12 Postoperative Treatment After Endoscopic Sinus Surgery Completed NCT00534768
13 Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis Active, not recruiting NCT00683371
14 Endosseous Oroantral Port for Minimal Intervention in Treating Chronic Sinusitis Not yet recruiting NCT03083392
15 Study Designed to Clinically Evaluate Sinus Wash Device Prototypes Not yet recruiting NCT02931604

Search NIH Clinical Center for Maxillary Sinusitis

Cochrane evidence based reviews: maxillary sinusitis

Genetic Tests for Maxillary Sinusitis

Anatomical Context for Maxillary Sinusitis

MalaCards organs/tissues related to Maxillary Sinusitis:

38
Eye, Bone, Testes, Tonsil, Colon, Skin

Publications for Maxillary Sinusitis

Articles related to Maxillary Sinusitis:

(show top 50) (show all 361)
# Title Authors Year
1
Clinical implications of taste thresholds in patients with odontogenic maxillary sinusitis. ( 29174862 )
2018
2
Novel approach to the maxillary sinusitis after sinus graft. ( 28695114 )
2017
3
Maxillary sinuses and midface in patients with cleidocranial dysostosis. ( 28889021 )
2017
4
Nasal Septal Deviation and Concha Bullosa - Do They Have an Impact on Maxillary Sinus Volumes and Prevalence of Maxillary Sinusitis? ( 28348652 )
2017
5
Role of Sinonasal Anatomic Variations in the Development of Maxillary Sinusitis: A Cone Beam CT Analysis. ( 28839485 )
2017
6
Subdural empyema as a complication of odontogenic maxillary sinusitis. ( 28843931 )
2017
7
Unusual case of odontogenic maxillary sinusitis. ( 28747419 )
2017
8
Clinical efficacy of main radiological diagnostic methods for odontogenic maxillary sinusitis. ( 28733779 )
2017
9
When Maxillary Sinusitis Does Not Heal: Findings on CBCT Scans of the Sinuses With a Particular Focus on the Occurrence of Odontogenic Causes of Maxillary Sinusitis. ( 29299521 )
2017
10
A Case of Fungus Ball-Type Maxillary Sinusitis Due to Penicillium Roqueforti. ( 29075960 )
2017
11
Haemophilus parainfluenzae Endocarditis Associated With Maxillary Sinusitis and Complicated by Cerebral Emboli in a Young Man. ( 28491883 )
2017
12
Radiological and clinical difficulties in the management of chronic maxillary sinusitis in I^ Thalassemic paediatric patients. ( 27063757 )
2016
13
Are Zygomatic Implants Associated With Maxillary Sinusitis? ( 27070844 )
2016
14
A 44-Year-Old Man with Waldenstrom Macroglobulinemia and Bilateral Maxillary Sinusitis. ( 27840358 )
2016
15
Root Cause Analysis: An Examination of Odontogenic Origins of Acute Maxillary Sinusitis in Both Immunocompetent & Immunocompromised Patients. ( 27798445 )
2016
16
Utilization of computer-aided detection system in diagnosing unilateral maxillary sinusitis on panoramic radiographs. ( 26837670 )
2016
17
Metastatic mammary carcinoma to the orbit masquerading as maxillary sinusitis. ( 27103558 )
2016
18
Salmonella enterica Subspecies diarizonae Maxillary Sinusitis in a Snake Handler: First Report. ( 27186588 )
2016
19
Haemophilus parainfluenzae endocarditis with systemic embolisation following maxillary sinusitis. ( 27599807 )
2016
20
Management of acute maxillary sinusitis after sinus bone grafting procedures with simultaneous dental implants placement - a retrospective study. ( 27169511 )
2016
21
Near-Infrared Optical Imaging for Diagnosis of Maxillary Sinusitis. ( 27329417 )
2016
22
Chronic Maxillary Sinusitis Caused by Denture Lining Material. ( 27386012 )
2016
23
Differential protein expression in the secretory fluids of maxillary sinusitis and maxillary retention cyst. ( 27422628 )
2016
24
Sporotrichosis of Maxillary Sinuses in a Middle Aged Female Patient from Rural Area of Eastern India. ( 27134873 )
2016
25
Impact of beta thalassemia on maxillary sinuses and sino-nasal passages: A case control study. ( 26553397 )
2015
26
Etiologies and Treatments of Odontogenic Maxillary Sinusitis: A Systematic Review. ( 26756016 )
2015
27
Intra-oral low level laser therapy in chronic maxillary sinusitis: A new and effective recommended technique. ( 26644829 )
2015
28
IRAK4 gene polymorphism and odontogenic maxillary sinusitis. ( 25707370 )
2015
29
Odontogenic maxillary sinusitis obscured by midfacial trauma. ( 26183855 )
2015
30
Maxillary sinusitis diagnosed by ultrasound. ( 25952933 )
2015
31
Etiology and clinical characteristics of symptomatic unilateral maxillary sinusitis: A review of 174 cases. ( 26319958 )
2015
32
WITHDRAWN: Antibiotics for acute maxillary sinusitis in adults. ( 26471061 )
2015
33
Is Le Fort I Osteotomy Associated With Maxillary Sinusitis? ( 26546843 )
2015
34
One stage combined endoscopic and per-oral buccal fat pad approach for large oro-antral-fistula closure with secondary chronic maxillary sinusitis. ( 26006724 )
2015
35
Chronic maxillary sinusitis and diabetes related maxillary osteonecrosis: a case report. ( 26734561 )
2015
36
Distinguishing the dominant species of pathogen in maxillary sinusitis by sequencing DNA dataset analysis. ( 25724392 )
2015
37
Large Haller cell mucocele leading to maxillary sinusitis. ( 25923288 )
2015
38
[The role of accessory ostia of the maxillary sinuses in pathogenesis of acute and chronic maxillary sinusitis]. ( 26640843 )
2015
39
Maxillary Sinusitis Caused by Dental Implants Extending into the Maxillary Sinus and the Nasal Cavities. ( 24417178 )
2014
40
Role of modified endoscopic medial maxillectomy in persistent chronic maxillary sinusitis. ( 25992084 )
2014
41
Long-term outcomes of endoscopic maxillary mega-antrostomy for refractory chronic maxillary sinusitis. ( 25312656 )
2014
42
Odontogenic maxillary sinusitis: a review. ( 25209225 )
2014
43
Correlation between the rate of asymmetry volume of maxillary sinuses and clinical symptomatology in the silent sinus syndrome: A retrospective study about 13 cases. ( 26521368 )
2014
44
Pathological changes in the maxillary sinus mucosae of patients with recurrent odontogenic maxillary sinusitis. ( 25225509 )
2014
45
Chronic maxillary sinusitis caused by root canal overfilling of Calcipex II. ( 24516832 )
2014
46
Antibiotics for acute maxillary sinusitis in adults. ( 24515610 )
2014
47
Endoscopic sinus surgery in individuals with facial pain due to chronic maxillary sinusitis - a functional controlled study. ( 25003399 )
2014
48
A case of coinfection in a chronic maxillary sinusitis of odontogenic origin: identification of Dialister pneumosintes. ( 23880283 )
2013
49
Maxillary sinusitis: 1752A cases at the ear-nose-throat department of a teaching hospital in Cotonou, Benin. ( 23747145 )
2013
50
Anomalous middle turbinate with choanal obstruction and maxillary sinusitis: a case report. ( 24134810 )
2013

Variations for Maxillary Sinusitis

Expression for Maxillary Sinusitis

Search GEO for disease gene expression data for Maxillary Sinusitis.

Pathways for Maxillary Sinusitis

Pathways related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 CCL5 CD79A IRAK4 MPO
2 10.64 MPO SELP

GO Terms for Maxillary Sinusitis

Cellular components related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CCL5 IRAK4 MPO RNASE3 SELP

Biological processes related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-negative bacterium GO:0050829 9.26 RNASE3 SELP
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.16 CCL5 SELP
3 positive regulation of smooth muscle cell proliferation GO:0048661 8.96 CCL5 IRAK4
4 leukocyte cell-cell adhesion GO:0007159 8.62 CCL5 SELP

Molecular functions related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 RNASE3 SELP

Sources for Maxillary Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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