MAS
MCID: MCC001
MIFTS: 76

Mccune Albright Syndrome (MAS) malady

Genetic diseases, Rare diseases, Reproductive diseases, Bone diseases, Skin diseases, Endocrine diseases, Fetal diseases, Cancer diseases categories
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Summaries for Mccune Albright Syndrome

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8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 47OMIM, 33MalaCards
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Fully expand this MalaCard
NIH Rare Diseases:43 Mccune-albright syndrome (mas) is a disease that affects the bones, skin, and several hormone-producing (endocrine) tissues. it is characterized by replacement of normal bone tissue with areas of abnormal fibrous growth (fibrous dysplasia); patches of abnormal skin coloring with jagged borders (cafe-au-lait spots); and abnormalities in the glands that regulate the body's rate of growth, sexual development, and other metabolic functions (multiple endocrine dysfunction). mas is caused by a change (mutation) in the gnas gene that occurs by chance very early in development. as a result, some of the body's cells have a normal version of the gnas gene, while other cells have the mutated version. this phenomenon is called mosaicism. the severity of mas and its features depend on the number and location of cells that have the mutated gnas gene. because mas occurs by chance, it is not inherited or passed down from one generation to the next. last updated: 12/26/2013

MalaCards: Mccune Albright Syndrome, also known as polyostotic fibrous dysplasia, is related to fibrous dysplasia and acromegaly, and has symptoms including bone pain, macropenis/megapenis/large penis and hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding. An important gene associated with Mccune Albright Syndrome is GNAS (GNAS complex locus), and among its related pathways are Growth hormone receptor signaling and Nuclear signaling by ERBB4. The compounds quinagolide and ghrp have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and pituitary, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Disease Ontology:8 An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. it is caused by mutations in the gnas1 gene.

Genetics Home Reference:21 McCune-Albright syndrome is a disorder that affects the bones, skin, and several hormone-producing (endocrine) tissues.

Description from OMIM:47 174800

Aliases & Classifications for Mccune Albright Syndrome

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8Disease Ontology, 9diseasecard, 65Wikipedia, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

49
mccune-albright syndrome:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Childhood; Age of death: Normal
fibrous dysplasia of bone:
Inheritance: Sporadic; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

mccune albright syndrome 8 43 10
polyostotic fibrous dysplasia 8 65 21 49 62
mccune-albright syndrome 9 21 47 49 62
osteitis fibrosa disseminata 8 21 62
mccune–albright syndrome 65 20 22
fibrous dysplasia of bone 8 49
osteofibrous dysplasia 49 62
albright's disease 43 21
albright syndrome 43 21
pofd 43 21
mas 43 21
pfd 43 21
fibrous dysplasia with pigmentary skin changes and precocious puberty 21
gonadotropin-independent female-limited sexual precocity 49
albright's syndrome with precocious puberty 21
albright-mccune-sternberg syndrome 21
fibrous dysplasia, polyostotic 21
properdin deficiency, x-linked 62
fibrous dysplasia polyostotic 45
albright-sternberg syndrome 21
albright's disease of bone 21
albright's syndrome 21


External Ids:

Disease Ontology8 DOID:1858
OMIM47 174800
MeSH35 D005357
MESH via Orphanet36 D005359, D005357
ICD10 via Orphanet26 Q78.1
SNOMED-CT via Orphanet59 36517007, 10623005
UMLS via Orphanet63 C0242292, C0016063, C0016065
ICD1025 M85.0, Q78.1

Related Diseases for Mccune Albright Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Mccune Albright Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous dysplasia31.8FGF23, GH1, GNAS
2acromegaly31.5PRL, GH1
3precocious puberty31.4GH1, PRL, GNRH1, GNAS
4hyperthyroidism31.2GNAS, PRL, GH1, FGF23
5gigantism31.1GNAS, PRL, GH1
6adenoma31.0GNAS, GNRH1, PRL, PRKAR1A, GH1
7pituitary adenoma31.0GNAS, GNRH1, PRL, PRKAR1A, GH1
8ovarian cyst30.9GNAS, GNRH1
9carney complex30.9PRKAR1A, GNAS
10hypophosphatemia30.8FGF23, PTHLH
11hyperparathyroidism30.7PTHLH, PRKAR1A, FGF23
12hypogonadotropism30.7GNRH1, PRL
13hypogonadism30.6GH1, PRL, GNRH1
14hyperprolactinemia30.6GNAS, GNRH1, PTHLH, PRL, GH1
15cushing's syndrome30.6PRL, PRKAR1A
16primary hyperparathyroidism30.6PTHLH, PRKAR1A, FGF23
17acth-independent macronodular adrenal hyperplasia30.6GNAS
18ollier disease30.5PTHLH
19empty sella syndrome30.5PRL, GH1
20infertility30.4FGF23, PRL, GNRH1
21pseudohypoparathyroidism30.4ADCY2, PTHLH, GNAS
22hypercalcemia30.3PTHLH, PRKAR1A, FGF23
23osteomalacia30.3GNAS, PTHLH, FGF23
24osteoporosis30.3PTHLH, PRKAR1A, GH1, FGF23
25pituitary tumors30.2GNAS, GNRH1, PRL, PRKAR1A, GH1
26breast cancer30.2GNRH1, PTHLH, PRL, PRKAR1A, GH1
27prolactinoma30.1GNAS, GNRH1, PTHLH, PRL, PRKAR1A, GH1
28pituitary apoplexy30.1GNRH1, PRL
29amenorrhea30.1GNRH1, PRL
30osteofibrous dysplasia11.1
31osteitis fibrosa10.7
32thyroiditis10.7
33forbes albright syndrome10.6
34rickets10.5
35osteosarcoma10.5
36testicular microlithiasis10.5
37somatostatin analog10.5
38peripheral precocious puberty10.5
39cervicitis10.5
40monostotic fibrous dysplasia10.4
41chondrosarcoma10.4
42neuropathy10.4
43mazabraud syndrome10.4
44hepatitis10.4
45pseudoarthrosis10.3
46neurofibromatosis10.3
47ductal carcinoma in situ10.3
48growth hormone secreting pituitary adenoma10.3
49paget's disease of bone10.3
50arteriovenous malformation10.3

Graphical network of the top 20 diseases related to Mccune Albright Syndrome:



Diseases related to mccune albright syndrome

Symptoms for Mccune Albright Syndrome

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47OMIM, 49Orphanet
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Symptoms by clinical synopsis from OMIM:

174800

Clinical features from OMIM:

174800

Symptoms:

49 (show all 35)
  • bone pain
  • macropenis/megapenis/large penis
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • cortico-adrenal hyperplasia/hypersecretion
  • hyperparathyroidy
  • breast neoplasm/tumor/carcinoma/cancer
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • testicular/seminal neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • thyroid neoplasm/tumor/carcinoma/cancer
  • palate anomalies
  • cushingoid morphotype
  • dental malocclusion
  • enamel anomaly
  • sarcoma
  • cafe-au-lait spot
  • macroorchidism/macrotestes
  • multiple caries
  • anomalies of teeth and dentition
  • prognathism/prognathia
  • dysostosis/chondrodysplasia/osteodysplasia/osteochondrosis/skeletal dysplasia
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • precocious puberty
  • kyphosis
  • optic nerve anomaly/optic atrophy/anomaly of the papilla
  • hypophosphatemia
  • anomalies of eyes and vision
  • abnormal hepatic enzymes/transaminases
  • tall stature/gigantism/growth acceleration
  • face/facial anomalies
  • hyperthyroidy
  • goiter
  • abnormal/polycystic ovaries
  • anomalies of ear and hearing
  • mutiple fractures/bone fragility
  • macrocephaly/macrocrania/megalocephaly/megacephaly

Drugs & Therapeutics for Mccune Albright Syndrome

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Mccune Albright Syndrome

Search NIH Clinical Center for Mccune Albright Syndrome

Genetic Tests for Mccune Albright Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Mccune Albright Syndrome:

id Genetic test Affiliating Genes
1 Mccune-Albright Syndrome20 22 GNAS

Anatomical Context for Mccune Albright Syndrome

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33MalaCards
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MalaCards organs/tissues related to Mccune Albright Syndrome:

33
Bone, Skin, Pituitary, Thyroid, Ovary, Breast, Eye, Testes, Myeloid

Animal Models for Mccune Albright Syndrome or affiliated genes

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37MGI
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Publications for Mccune Albright Syndrome

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52PubMed
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Articles related to Mccune Albright Syndrome:

(show top 50)    (show all 319)
idTitleAuthorsYear
1
Hepatobiliary and Pancreatic Neoplasms in Patients With McCune-Albright Syndrome. (24170100)
2014
2
Transsphenoidal approach for pituitary adenomas in patients with McCune-Albright syndrome. (22797802)
2013
3
Intragenic suppression of a constitutively active allele of GsI+ associated with McCune-Albright syndrome. (23288949)
2013
4
Oral manifestations of McCune-Albright syndrome. (23776876)
2013
5
Fulvestrant treatment of precocious puberty in girls with McCune-Albright syndrome. (22999294)
2012
6
Hansen's disease with McCune-Albright syndrome. (23326081)
2012
7
Gastrointestinal polyps in McCune Albright syndrome. (21357941)
2011
8
Primary bimorphic adrenocortical disease: cause of hypercortisolism in McCune-Albright syndrome. (21836496)
2011
9
Upper lip bite test in a patient with McCune Albright syndrome with acromegaly. (20036127)
2010
10
McCune-Albright Syndrome: intensely hypermetabolic polyostotic fibrous dysplasia on F-18 FDG-PET. (19851179)
2009
11
Oral rehabilitation with endosseous implants in a patient with fibrous dysplasia (McCune-Albright syndrome): a case report. (19022142)
2008
12
Combined treatment with ketoconazole and cyproterone acetate in a boy with McCune-Albright syndrome and peripheral precocious puberty. (18997496)
2008
13
McCune-Albright syndrome: 70 years of fascination and discovery. (17937058)
2007
14
The spectrum of McCune Albright syndrome. (17982388)
2007
15
McCune-Albright syndrome associated with acromegaly and bipolar affective disorder. (18054713)
2007
16
Clinical approach to clarifying the mechanism of abnormal bone metabolism in McCune-Albright syndrome. (16369891)
2006
17
McCune-Albright syndrome and acromegaly: effects of hypothalamopituitary radiotherapy and/or pegvisomant in somatostatin analog-resistant patients. (16984995)
2006
18
Unexpected mosaicism of R201H-GNAS1 mutant-bearing cells in the testes underlie macro-orchidism without sexual precocity in McCune-Albright syndrome. (17101633)
2006
19
Clinical presentation of McCune-Albright syndrome in males. (16789625)
2006
20
McCune-Albright syndrome: growth hormone and prolactin hypersecretion. (16789626)
2006
21
Lack of efficacy of fadrozole in treating precocious puberty in girls with the McCune-Albright syndrome. (14671160)
2003
22
McCune-Albright syndrome with thyrotoxicosis. (11564936)
2001
23
Infantile McCune-Albright syndrome. (11841638)
2001
24
Neurofibromatosis type 1 and McCune-Albright syndrome occurring in the same patient. (11122036)
2000
25
McCune-Albright syndrome associated with non-autoimmune type of hyperthyroidism with development of thyrotoxic crisis. (11150888)
2000
26
Meningioma associated with McCune-Albright syndrome. (10653317)
1999
27
Activating mutation of GS alpha in McCune-Albright syndrome causes skin pigmentation by tyrosinase gene activation on affected melanocytes. (10844413)
1999
28
Tamoxifen treatment of progressive precocious puberty in a patient with McCune-Albright syndrome. (10703542)
1999
29
Ketoconazole treatment of gonadotropin independent precocious puberty in girls with McCune-Albright syndrome: a preliminary report. (10392352)
1999
30
Chondrosarcoma in a patient with McCune-Albright syndrome. Report of a case. (10327499)
1999
31
Secondary central precocious puberty in a girl with McCune-Albright syndrome responds to treatment with GnRH analogue. (9642633)
1998
32
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation. (9403710)
1997
33
McCune-Albright syndrome (polyostotic fibrous dysplasia) with intracranial frontoethmoid mucocele. (9141412)
1997
34
Clinical implications of genetic defects in G proteins. The molecular basis of McCune-Albright syndrome and Albright hereditary osteodystrophy. (8699958)
1996
35
Growth hormone-prolactin-thyrotropin-secreting pituitary adenoma in atypical McCune-Albright syndrome with functionally normal Gs alpha protein. (7962285)
1994
36
Residents' corner. Answer to case of the month #12. McCune-Albright syndrome (polyostotic fibrous dysplasia). (1562893)
1992
37
Pathologic fracture of the femoral neck in a patient with McCune-Albright syndrome. (1608869)
1992
38
In vitro production of estradiol by ovarian granulosa cells in a case of McCune-Albright syndrome. (1865081)
1991
39
Thyroid abnormalities in the McCune-Albright syndrome: ultrasonography and hormonal studies. (2229316)
1990
40
Hypersecretion of growth hormone and prolactin in McCune-Albright syndrome. (2498385)
1989
41
McCune-Albright syndrome with gigantism and hyperprolactinemia. (3680873)
1987
42
The McCune-Albright syndrome. (3545811)
1987
43
Value of bone scan in the McCune-Albright syndrome. Report of a case. (3812022)
1986
44
Autonomous ovarian hyperfunction followed by gonadotrophin-dependent puberty in McCune-Albright syndrome. (3085997)
1986
45
Testolactone treatment of precocious puberty in McCune-Albright syndrome. (3925675)
1985
46
McCune-Albright syndrome (fibrous dysplasia) associated with an orbital tumor. (6712072)
1984
47
Cyclical ovarian function resistant to treatment with an analogue of luteinizing hormone releasing hormone in McCune-Albright syndrome. (6434946)
1984
48
Hyperprolactinaemia in a patient with the McCune-Albright Syndrome. (571285)
1979
49
McCune-Albright syndrome with endocrinological investigations. Report of a case. (5410568)
1970
50
Sexual precocity in females; report of two cases, with arrest of precocity in the McCune-Albright syndrome after removal of a cystic ovary. (14891326)
1951

Variations for Mccune Albright Syndrome

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64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Mccune Albright Syndrome:

64
id Symbol AA change Variation ID SNP ID
1GNASp.Arg201HisVAR_003441
2GNASp.Arg201CysVAR_003442rs11554273
3GNASp.Arg201GlyVAR_017844

Clinvar genetic disease variations for Mccune Albright Syndrome:

1
id Gene Name Type Significance SNP ID Assembly Location
1CFPNM_002621.2(CFP): c.481C> T (p.Arg161Ter)single nucleotide variantPathogenicrs132630258GRCh37Chr X, 47486963: 47486963
2CFPNM_002621.2(CFP): c.893G> T (p.Gly298Val)single nucleotide variantPathogenicrs28935480GRCh37Chr X, 47486219: 47486219
3CFPNM_002621.2(CFP): c.617C> G (p.Ser206Ter)single nucleotide variantPathogenicrs132630260GRCh37Chr X, 47486689: 47486689
4GNASNM_001077488.2(GNAS): c.604C> T (p.Arg202Cys)single nucleotide variantPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420
5GNASNM_001077488.2(GNAS): c.605G> A (p.Arg202His)single nucleotide variantPathogenicrs121913495GRCh37Chr 20, 57484421: 57484421
6GNASNM_001077488.2(GNAS): c.604C> G (p.Arg202Gly)single nucleotide variantPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420

Expression for genes affiliated with Mccune Albright Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mccune Albright Syndrome

Search GEO for disease gene expression data for Mccune Albright Syndrome.

Pathways for genes affiliated with Mccune Albright Syndrome

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50PathCards, 55Reactome, 51PharmGKB, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN
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Pathways related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GH1, PRL
2
Show member pathways
9.6PRL, GH1
39.6ADCY2, GNAS
49.6GNAS, ADCY2
59.6ADCY2, GNAS
69.6ADCY2, GNAS
79.6ADCY2, GNAS
89.6GNAS, ADCY2
99.4GH1, PTHLH
10
Show member pathways
9.3PRKAR1A, GNAS
119.3GNAS, PRKAR1A
129.2PRL, GH1, FGF23
13
Show member pathways
9.2FGF23, GH1, PRL
14
Show member pathways
9.2FGF23, ADCY2, GNAS
159.1PRKAR1A, ADCY2
16
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.1GNAS, GNRH1, ADCY2
179.0ADCY2, PTHLH, GNAS
18
Show member pathways
9.0ADCY2, PTHLH, GNAS
19
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.9GNAS, PRKAR1A, GH1
20
Show member pathways
8.8GNAS, ADCY2, PRKAR1A
21
Show member pathways
8.8GNAS, ADCY2, PRKAR1A
22
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
8.8GNAS, ADCY2, PRKAR1A
238.8GNAS, ADCY2, PRKAR1A
24
Show member pathways
Signal transduction cAMP signaling60
8.8PRKAR1A, ADCY2, GNAS
25
Show member pathways
8.8PRKAR1A, ADCY2, GNAS
26
Show member pathways
8.8PRKAR1A, ADCY2, GNAS
27
Show member pathways
Calcium Regulation in the Cardiac Cell38
8.8PRKAR1A, ADCY2, GNAS
28
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
8.8PRKAR1A, ADCY2, GNAS
29
Show member pathways
8.8FGF23, PRKAR1A, ADCY2
30
Show member pathways
8.7ADCY2, PRKAR1A, GH1
31
Show member pathways
8.7GNRH1, PRL, GH1, FGF23
328.7GNAS, PTHLH, PRKAR1A
33
Show member pathways
8.6FGF23, GH1, ADCY2, GNRH1
34
Show member pathways
8.6PRKAR1A, ADCY2, GNRH1
35
Show member pathways
8.6PRKAR1A, ADCY2, GNRH1
36
Show member pathways
8.4GNAS, ADCY2, PRKAR1A, FGF23
37
Show member pathways
8.3GNRH1, PRKAR1A, GH1, FGF23
38
Show member pathways
8.3FGF23, GH1, PRKAR1A, GNRH1
398.3ADCY2, PRL, PRKAR1A, FGF23
40
Show member pathways
7.9ADCY2, PRL, PRKAR1A, GH1, FGF23
41
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
42
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
43
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
44
Show member pathways
7.8FGF23, GH1, PRKAR1A, ADCY2, GNRH1
45
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
46
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
47
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
48
Show member pathways
7.6GNAS, GNRH1, PTHLH, ADCY2, PRL, GH1
49
Show member pathways
6.4FGF23, GNAS, GNRH1, PTHLH, ADCY2, PRL

Compounds for genes affiliated with Mccune Albright Syndrome

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45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1quinagolide4510.0PRL, GH1
2ghrp459.8GH1, PRL
3estradiol benzoate459.7GNRH1, PRL
4leuprolide45 61 29 1112.7GNRH1, PRL
55-hydroxytryptophan459.7GH1, PRL
6adenosine 3,5-cyclic monophosphorothioate459.7PTHLH, GNRH1
7mhpg459.6GNRH1, PRL
8hexarelin45 2910.6PRL, GH1
9lanreotide45 2910.6PRL, GH1
10leuprolide acetate459.5GNRH1, PRL, GH1
11clomiphene citrate459.5PRL, GNRH1, GH1
12pyridostigmine45 1110.5GH1, PRL
13naltrexone45 29 51 1112.5GNRH1, PRL, GH1
14cabergoline45 29 1111.5GH1, PRL, GNRH1
15metoclopramide45 51 1111.5GH1, GNRH1, PRL
16bromocriptine45 29 1111.5GNRH1, GH1, PRL
17naloxone45 29 51 1112.5PRL, GNRH1, GH1
18dehydroepiandrosterone sulfate459.5PRL, GNRH1, GH1
19opiate459.5GH1, GNRH1, PRL
20androstenedione45 2410.4GH1, GNRH1, PRL
21estrone45 29 24 1112.4GH1, GNRH1, PRL
221,25 dihydroxy vitamin d3459.4FGF23, GH1, PTHLH
23sulpiride45 29 1111.3PRL, GH1
24hydrocortisone45 3 61 1112.3GH1, PRL, PTHLH
25progestin459.2GNRH1, PRL, PTHLH
26verapamil45 29 51 24 1113.2GNRH1, PTHLH, GH1
27nifedipine45 29 51 1112.2GH1, PTHLH, GNRH1
28acth459.1GH1, PRL, GNAS, GNRH1
29gnrh459.1GH1, PRL, GNRH1, GNAS
30dihydrotestosterone45 29 24 1111.9GH1, PTHLH, PRL, GNRH1
31thyroxine45 249.9GH1, PRL, PTHLH, GNRH1
32creatinine458.9FGF23, GH1, GNRH1, PTHLH
33tamoxifen45 51 29 1111.8GH1, PRL, PTHLH, GNRH1
34heparin45 29 24 1111.8GNRH1, FGF23, GH1, PTHLH
35estradiol45 24 1110.8GNRH1, PTHLH, PRL, GH1
36dopamine45 29 24 1111.7PRL, GNAS, GNRH1, ADCY2, GH1
37vitamin d458.6PRKAR1A, GH1, FGF23, PTHLH
38testosterone45 61 24 1111.6GH1, PRL, PTHLH, GNRH1
39ribonucleic acid458.6GNRH1, GNAS, GH1, PRL, PTHLH
40norepinephrine45 24 1110.6PTHLH, GNRH1, GNAS, PRL, GH1
41progesterone45 29 61 24 1112.5GH1, GNRH1, GNAS, PTHLH, PRL
42isoproterenol45 119.5ADCY2, PTHLH, GNRH1, GNAS, GH1
43cyclic amp45 249.4GNAS, PRKAR1A, ADCY2, PTHLH
44octreotide45 61 29 1111.2PTHLH, PRL, GNRH1, GNAS, GH1, FGF23
45forskolin45 51 1110.2GH1, PRKAR1A, ADCY2, PTHLH, GNAS
46glucose458.2PRL, GNAS, PTHLH, PRKAR1A, GH1
47dexamethasone45 51 29 1111.0PRKAR1A, GNRH1, PRL, PTHLH, GH1
48steroid457.7PRL, PRKAR1A, GH1, PTHLH, GNAS, GNRH1
49adenylate457.7GNRH1, ADCY2, PRKAR1A, GH1, GNAS, PTHLH
50arginine457.4GNAS, GNRH1, PRL, PRKAR1A, GH1, FGF23

GO Terms for genes affiliated with Mccune Albright Syndrome

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16Gene Ontology
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Cellular components related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5FGF23, GH1, PTHLH, GNRH1
2extracellular regionGO:0055767.4FGF23, GNAS, GNRH1, PTHLH, PRL, GH1

Biological processes related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1cAMP biosynthetic processGO:0061719.9ADCY2, GNAS
2positive regulation of JAK-STAT cascadeGO:0464279.9GH1, PRL
3JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.8GH1, PRL
4endochondral ossificationGO:0019589.6PTHLH, GNAS
5positive regulation of cAMP biosynthetic processGO:0308199.5PTHLH, GNAS
6activation of protein kinase A activityGO:0341999.3PRKAR1A, ADCY2
7regulation of insulin secretionGO:0507969.3PRKAR1A, GNAS
8adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.3GNAS, PTHLH, ADCY2
9regulation of gene expressionGO:0104689.2PTHLH, GNRH1
10cellular response to glucagon stimulusGO:0713779.1GNAS, ADCY2, PRKAR1A
11water transportGO:0068339.1GNAS, ADCY2, PRKAR1A
12energy reserve metabolic processGO:0061129.1GNAS, ADCY2, PRKAR1A
13fibroblast growth factor receptor signaling pathwayGO:0085439.0ADCY2, PRKAR1A, FGF23
14epidermal growth factor receptor signaling pathwayGO:0071738.9ADCY2, PRKAR1A, FGF23
15female pregnancyGO:0075658.8PRL, PTHLH, GNRH1, GNAS
16activation of phospholipase C activityGO:0072028.8PRKAR1A, ADCY2
17neurotrophin TRK receptor signaling pathwayGO:0480118.8ADCY2, PRKAR1A, FGF23

Molecular functions related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein beta/gamma-subunit complex bindingGO:0316839.6ADCY2, GNAS
2prolactin receptor bindingGO:0051489.5PRL, GH1
3adenylate cyclase activityGO:0040169.3ADCY2, GNAS
4hormone activityGO:0051798.5GH1, PRL, PTHLH, GNRH1

Products for genes affiliated with Mccune Albright Syndrome

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Sources for Mccune Albright Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet