MAS
MCID: MCC001
MIFTS: 71

Mccune Albright Syndrome (MAS) malady

Reproductive, Bone, Skin, Endocrine, Fetal, Cancer categories

Summaries for Mccune Albright Syndrome

Sources:
8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Mccune-albright syndrome (mas) is a disease that affects the bones, skin, and several hormone-producing (endocrine) tissues. it is characterized by replacement of normal bone tissue with areas of abnormal fibrous growth (fibrous dysplasia); patches of abnormal skin coloring with jagged borders (cafe-au-lait spots); and abnormalities in the glands that regulate the body's rate of growth, sexual development, and other metabolic functions (multiple endocrine dysfunction). mas is caused by a change (mutation) in the gnas gene that occurs by chance very early in development. as a result, some of the body's cells have a normal version of the gnas gene, while other cells have the mutated version. this phenomenon is called mosaicism. the severity of mas and its features depend on the number and location of cells that have the mutated gnas gene. because mas occurs by chance, it is not inherited or passed down from one generation to the next. last updated: 12/26/2013

MalaCards: Mccune Albright Syndrome, also known as mccune-albright syndrome, is related to fibrous dysplasia and osteofibrous dysplasia, and has symptoms including diffuse/generalised skin hyperpigmentation/melanoderma, cafe-au-lait spot and precocious puberty. An important gene associated with Mccune Albright Syndrome is GNAS (GNAS complex locus), and among its related pathways are Osteoblast Signaling and Regulation of Insulin Secretion by Free Fatty Acids. The compounds forskolin and procollagen have been mentioned in the context of this disorder. Affiliated tissues include whole blood, thyroid and breast, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Disease Ontology:8 An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. it is caused by mutations in the gnas1 gene.

Genetics Home Reference:21 McCune-Albright syndrome is a disorder that affects the bones, skin, and several hormone-producing (endocrine) tissues.

Description from OMIM:47 174800

Aliases & Classifications for Mccune Albright Syndrome

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal, Cancer
Anatomical: Reproductive, Bone, Skin, Endocrine


Characteristics (Orphanet epidemiological data):

49
mccune-albright syndrome:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Childhood; Age of death: Normal
fibrous dysplasia of bone:
Inheritance: Sporadic; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

mccune albright syndrome 8 43 10
mccune-albright syndrome 9 20 22 21 47 49 61
polyostotic fibrous dysplasia 8 21 49 61
osteitis fibrosa disseminata 8 21 61
fibrous dysplasia of bone 8 49
osteofibrous dysplasia 49 61
albright's disease 43 21
albright syndrome 43 21
pofd 43 21
mas 43 21
pfd 43 21
fibrous dysplasia with pigmentary skin changes and precocious puberty 21
gonadotropin-independent female-limited sexual precocity 49
albright's syndrome with precocious puberty 21
albright-mccune-sternberg syndrome 21
properdin deficiency, x-linked 61
fibrous dysplasia, polyostotic 21
fibrous dysplasia polyostotic 45
albright-sternberg syndrome 21
albright's disease of bone 21
jaffe-lichtenstein disease 49
albright's syndrome 21


External Ids:

Disease Ontology8 DOID:1858
OMIM47 174800
MeSH35 D005357
MESH via Orphanet36 D005359, D005357
ICD10 via Orphanet26 Q78.1
SNOMED-CT via Orphanet58 36517007, 10623005
UMLS via Orphanet62 C0242292, C0016065
ICD1025 M85.0, Q78.1

Related Diseases for Mccune Albright Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mccune Albright Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 231)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous dysplasia31.7GNAS, GNA11, IBSP, GNA15, GH1, FGF23
2osteofibrous dysplasia31.6SPARC, GNAS
3precocious puberty31.4AMH, GNAS, GNRH1, GH1, PRL, CYP19A1
4acromegaly31.3GNAS, GNRH1, MEN1, GH1, PRL, TRH
5adenoma31.1GNAS, GNRH1, DIO2, MEN1, GH1, PRL
6osteitis fibrosa31.0GNAS, ALPP
7gigantism31.0GNAS, GH1, PRL
8cushing's syndrome31.0GNAS, GNRH1, MEN1, GH1, PRL, TRH
9carney complex30.8MEN1, GNAS
10rickets30.7FGF23, ALPP
11hypophosphatemia30.7FGF23, SLC34A1, ALPP
12hyperprolactinemia30.7TRH, PRL, GH1, GNRH1, GNAS
13primary hyperparathyroidism30.6IBSP, MEN1, FGF23, ALPP
14empty sella syndrome30.3GH1, PRL
15hypercalcemia30.3ALPP, FGF23, MEN1
16osteogenesis imperfecta30.3ALPP, SPARC, IBSP
17bone carcinoma30.3IBSP, SPARC, ALPP
18thyrotoxicosis30.3TRH
19osteoporosis30.3ALPP, SPARC, FGF23, CYP19A1, GH1, IBSP
20infertility30.3FGF23, CYP19A1, PRL, GNRH1, AMH
21prolactinoma30.3TRH, PRL, GH1, MEN1, GNRH1, GNAS
22osteomalacia30.2ALPP, FGF23, GNAS
23pituitary apoplexy29.9GNRH1, PRL, TRH
24amenorrhea29.9AMH, GNRH1, PRL, TRH
25adenocarcinoma29.8IBSP, DIO2, MEN1, SPARC
26polycystic ovary syndrome29.8GNRH1, GH1, PRL, CYP19A1
27mccune–albright syndrome11.5
28n syndrome10.9
29micro syndrome10.6
30forbes albright syndrome10.6
31mazabraud syndrome10.6
32adult syndrome10.5
33char syndrome10.5
34young syndrome10.5
35testicular microlithiasis10.5
36somatostatin analog10.5
37peripheral precocious puberty10.5
38monostotic fibrous dysplasia10.4
39growth hormone secreting pituitary adenoma10.4
40bod syndrome10.4
41mass syndrome10.4
42meconium aspiration syndrome10.4
43renal dysplasia10.3
44pseudoarthrosis10.3
45congenital pseudoarthrosis10.3
46giant cell reparative granuloma10.2
47cleft palate10.2
48myositis ossificans10.2
49midface dysplasia10.2
50ollier disease10.2

Graphical network of the top 20 diseases related to Mccune Albright Syndrome:



Diseases related to mccune albright syndrome

Clinical Features for Mccune Albright Syndrome

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

174800

Clinical synopsis from OMIM:

174800

Symptoms:

49 (show all 35)
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • cafe-au-lait spot
  • precocious puberty
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • dysostosis/chondrodysplasia/osteodysplasia/osteochondrosis/skeletal dysplasia
  • mutiple fractures/bone fragility
  • bone pain
  • hypophosphatemia
  • macrocephaly/macrocrania/megalocephaly/megacephaly
  • face/facial anomalies
  • prognathism/prognathia
  • dental malocclusion
  • anomalies of eyes and vision
  • optic nerve anomaly/optic atrophy/anomaly of the papilla
  • palate anomalies
  • anomalies of teeth and dentition
  • enamel anomaly
  • multiple caries
  • anomalies of ear and hearing
  • kyphosis
  • abnormal hepatic enzymes/transaminases
  • abnormal/polycystic ovaries
  • macropenis/megapenis/large penis
  • macroorchidism/macrotestes
  • goiter
  • hyperthyroidy
  • hyperparathyroidy
  • cortico-adrenal hyperplasia/hypersecretion
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • breast neoplasm/tumor/carcinoma/cancer
  • testicular/seminal neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • thyroid neoplasm/tumor/carcinoma/cancer
  • sarcoma
  • tall stature/gigantism/growth acceleration
  • cushingoid morphotype

Drugs & Therapeutics for Mccune Albright Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Mccune Albright Syndrome

Drug clinical trials:

Search ClinicalTrials for Mccune Albright Syndrome

Search NIH Clinical Center for Mccune Albright Syndrome

Search CenterWatch for Mccune Albright Syndrome

Genetic Tests for Mccune Albright Syndrome

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Mccune Albright Syndrome:

id Genetic test Affiliating Genes
1 Mccune-albright Syndrome20 22 GNAS

Anatomical Context for Mccune Albright Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Mccune Albright Syndrome:

33
Whole blood, Thyroid, Breast, Skin, Ovary, Myeloid, Fetal thyroid, Pituitary

Animal Models for Mccune Albright Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Mccune Albright Syndrome

Sources:
51PubMed
See all sources

Articles related to Mccune Albright Syndrome:

(show top 50)    (show all 331)
idTitleAuthorsYear
1
Intragenic suppression of a constitutively active allele of GsI+ associated with McCune-Albright syndrome. (23288949)
2013
2
Oral manifestations of McCune-Albright syndrome. (23776876)
2013
3
Gigantism Treated by Pure Endoscopic Endonasal Approach in a Case of McCune-Albright Syndrome with Sphenoid Fibrous Dysplasia: A Case Report. (23307306)
2013
4
Quantitative and sensitive detection of GNAS mutations causing mccune-albright syndrome with next generation sequencing. (23536913)
2013
5
Sinonasal disease in polyostotic fibrous dysplasia and McCune-Albright Syndrome. (23444264)
2013
6
Diagnosis and management of precocious puberty in atypical presentations of McCune-Albright syndrome: a case series review. (22051789)
2012
7
Primary bimorphic adrenocortical disease: cause of hypercortisolism in McCune-Albright syndrome. (21836496)
2011
8
McCune-Albright syndrome: surgical and therapeutic challenges in GH-secreting pituitary adenomas. (21104108)
2011
9
McCune-Albright syndrome revealed by hyperthyroidism at advanced age. (22030539)
2011
10
Mazabraud syndrome associated with McCune-Albright syndrome. (21264480)
2011
11
Massive allograft of the tibia for a child with McCune-Albright syndrome: case presentation and surgical intervention. (19949350)
2010
12
McCune-Albright Syndrome: intensely hypermetabolic polyostotic fibrous dysplasia on F-18 FDG-PET. (19851179)
2009
13
Osteosarcoma in a pregnant patient with McCune-Albright syndrome. (19481621)
2009
14
Severe arterial hypertension: a possible complication of McCune-Albright syndrome. (18958498)
2009
15
Oral rehabilitation with endosseous implants in a patient with fibrous dysplasia (McCune-Albright syndrome): a case report. (19022142)
2008
16
McCune-Albright syndrome. (18489744)
2008
17
McCune-Albright syndrome. (18341085)
2007
18
McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamping method. (17878646)
2007
19
Laparoscopic management of ovarian cysts in peripheral precocious puberty of McCune-Albright syndrome. (16789619)
2006
20
Image diagnosis in McCune-Albright syndrome. (16789618)
2006
21
Genetics of McCune-Albright syndrome. (16789620)
2006
22
Accelerated bone turnover in pregnant women with McCune-Albright syndrome. (15860920)
2005
23
A highly sensitive polymerase chain reaction method detects activating mutations of the GNAS gene in peripheral blood cells in McCune-Albright syndrome or isolated fibrous dysplasia. (16264125)
2005
24
Parental origin of Gsalpha mutations in the McCune-Albright syndrome and in isolated endocrine tumors. (15181091)
2004
25
Management of infertility in a patient presenting with ovarian dysfunction and McCune-Albright syndrome. (15001590)
2004
26
Ductal carcinoma in situ in a 27-year-old woman with McCune-Albright syndrome. (15327499)
2004
27
Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutations. (12970318)
2003
28
Dental characteristics of fibrous dysplasia and McCune-Albright syndrome. (12973283)
2003
29
Is McCune-Albright syndrome overlooked in subjects with fibrous dysplasia of bone? (12756386)
2003
30
Ovarian function in an adult woman with McCune-Albright syndrome. (11889222)
2002
31
Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome. (12199354)
2002
32
A novel, complex heterozygous mutation within Gsalpha gene in patient with McCune-Albright syndrome. (12374458)
2002
33
Infantile McCune-Albright syndrome. (11841638)
2001
34
Macroorchidism due to autonomous hyperfunction of Sertoli cells and G(s)alpha gene mutation: an unusual expression of McCune-Albright syndrome in a prepubertal boy. (11297617)
2001
35
McCune-Albright syndrome associated with non-autoimmune type of hyperthyroidism with development of thyrotoxic crisis. (11150888)
2000
36
Intravenous pamidronate treatment of polyostotic fibrous dysplasia associated with the McCune Albright syndrome. (10969268)
2000
37
Meningioma associated with McCune-Albright syndrome. (10653317)
1999
38
McCune-Albright syndrome: a longitudinal clinical study of 32 patients. (10614538)
1999
39
Gs alpha mutation at codon 201 in pituitary adenoma causing gigantism in a 6-year-old boy with McCune-Albright syndrome. (8923825)
1996
40
Urinary cyclic adenosine 3',5'-monophosphate response in McCune-Albright syndrome: clinical evidence for altered renal adenylate cyclase activity. (8530601)
1995
41
An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome. (8077356)
1994
42
Digital clubbing in a patient with McCune Albright syndrome. (7971639)
1994
43
Residents' corner. Answer to case of the month #12. McCune-Albright syndrome (polyostotic fibrous dysplasia). (1562893)
1992
44
A case of neonatal McCune-Albright syndrome with Cushing syndrome and hyperthyroidism. (1755313)
1991
45
Thyroid abnormalities in the McCune-Albright syndrome: ultrasonography and hormonal studies. (2229316)
1990
46
Contraceptive methods in the McCune-Albright syndrome. (2627741)
1989
47
Value of bone scan in the McCune-Albright syndrome. Report of a case. (3812022)
1986
48
Ovarian function in girls with McCune-Albright syndrome. (3092175)
1986
49
Fibrous dysplasia and precocious puberty (McCune-Albright syndrome). (441783)
1979
50
Picture of the month. Polyostotic fibrous dysplasia (McCune-Albright syndrome). (4745152)
1973

Genetic Variations for Mccune Albright Syndrome

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Mccune Albright Syndrome:

63
id Symbol AA change Variation SNP ID
1GNASp.Arg201HisVAR_003441
2GNASp.Arg201CysVAR_003442rs11554273
3GNASp.Arg201GlyVAR_017844

Expression for genes affiliated with Mccune Albright Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mccune Albright Syndrome

Search GEO for disease gene expression data for Mccune Albright Syndrome.

Pathways for genes affiliated with Mccune Albright Syndrome

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 30KEGG, 50PharmGKB, 52QIAGEN
See all sources

Pathways related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2FGF23, IBSP
2
Hide members
10.0GNA15, GNA11
3
Development A2B receptor- action via G-protein alpha s
Hide members
9.9GNA11, GNAS, ADCY1
49.9GNAS, CYP19A1, ADCY1
59.9GNA15, GNAS, GNA11
69.8GNA11, GNA15, ADCY1
7
Development A3 receptor signaling
Hide members
9.8GNA11, GNA15, ADCY1
8
Hide members
9.8ADCY1, GNA15, GNA11
9
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
9.8IBSP, GNA11, GNAS, ADCY1
10
Development Endothelin-1/EDNRA signaling
Hide members
9.7GNA11, GNAS, GNRH1, ADCY1
11
Hide members
9.7ADCY1, GNA15, GNAS, GNA11
129.7ADCY1, GNA15, GNAS, GNA11
13
Development Dopamine D2 receptor transactivation of EGFR
Hide members
9.7GNA11, GNAS, GNA15, ADCY1
14
Hide members
9.7GNA11, GNAS, GNA15, ADCY1
159.7ADCY1, GNA15, GNAS, GNA11
16
Signal transduction cAMP signaling
Hide members
9.7GNA11, GNAS, GNA15, ADCY1
17
Hide members
9.6TRH, GNA15, GNRH1, GNA11
18
Hide members
9.5GNA11, GNRH1, GNA15, GH1, FGF23
19
Hide members
9.4GNAS, GNRH1, GH1, PRL, TRH, ADCY1
20
Hide members
9.4GNA11, GNRH1, GNA15, GH1, PRL, FGF23
21
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
22
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
23
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
24
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
25
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
26
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
27
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
28
Hide members
8.4ADCY1, IBSP, GNA11, GNAS, GNRH1, GNA15

Compounds for genes affiliated with Mccune Albright Syndrome

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 2BitterDB, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1forskolin45 50 1112.6IBSP
2procollagen4510.4ALPP
31,25 dihydroxy vitamin d34510.4IBSP, FGF23, SLC34A1
4estrogen4510.3LMOD1, TRH, DIO2
5bromocriptine29 45 1112.2GNRH1, PRL, TRH
6estradiol benzoate4510.2GNRH1, PRL, CYP19A1
7ghrp4510.2GH1, TRH, PRL
8leuprolide acetate4510.2PRL, GNRH1, GH1, CYP19A1
9clomiphene citrate4510.2GNRH1, CYP19A1, GH1, PRL
10alizarin4510.2SPARC, IBSP, ALPP
11pyridostigmine45 1111.1PRL, TRH, GH1
12metoclopramide45 1111.1GH1, PRL, GNRH1, TRH
13sulpiride45 29 1112.1PRL, TRH, GH1
14zoledronic acid4510.1CYP19A1, IBSP, GNRH1, ALPP
15dehydroepiandrosterone sulfate4510.1CYP19A1, PRL, GH1, GNRH1
16propylthiouracil45 2 1112.1LMOD1, ALPP, DIO2
17pyridinoline4510.1GH1, SPARC, IBSP, ALPP
18naloxone45 50 29 1113.1TRH, GNRH1, PRL, GH1
19buserelin45 29 1112.1PRL, GNRH1, CYP19A1
20iodine45 2411.0DIO2, GNAS, TRH, LMOD1, DIO1
21melatonin45 60 29 11 2414.0CYP19A1, PRL, GH1, IBSP, TRH
22naltrexone45 50 29 1113.0GH1, PRL, GNRH1
23hydroxyapatite459.9FGF23, SPARC, ALPP, IBSP
24toremifene45 1110.9CYP19A1, PRL, GNRH1
25octreotide45 60 29 1112.9GNAS, GNRH1, GH1, PRL, TRH, FGF23
26androstenedione45 2410.9GH1, CYP19A1, PRL, GNRH1
27hydrocortisone45 2 60 1112.9TRH, PRL, ALPP, GH1, CYP19A1
28triiodothyronine459.8DIO1, LMOD1, TRH, PRL, GH1, DIO2
29calcitriol45 60 11 2412.8SPARC, SLC34A1, GH1, FGF23, ALPP
30gnrh459.8GH1, GNRH1, TRH, GNAS, CYP19A1, PRL
31acth459.8GNAS, TRH, GH1, PRL, ADCY1, GNRH1
32tamoxifen45 50 29 1112.8PRL, ALPP, GNRH1, AMH, GH1, CYP19A1
33progestin459.8ALPP, CYP19A1, PRL, GNRH1
34dopamine45 29 11 2412.8DIO2, GNAS, ADCY1, LMOD1, TRH, GNRH1
35creatinine459.7ADCY1, GNRH1, FGF23, CFD, ALPP, IBSP
36ibmx45 29 6011.7GH1, TRH, CFD, ALPP, ADCY1, IBSP
37cysteine459.7SPARC, LMOD1, DIO2, GNAS, DIO1, IBSP
38norepinephrine45 11 2411.7GNRH1, PRL, GNAS, TRH, ALPP, GH1
39estradiol45 11 2411.7GNRH1, GH1, PRL, TRH, AMH, CYP19A1
40ribonucleic acid459.6PRL, GNRH1, GNAS, DIO2, GH1
41thymidine45 2410.5IBSP, GNAS, GH1, ALPP, TRH, SPARC
42steroid459.5SPARC, IBSP, CYP19A1, GNAS, GNRH1, PRL
43vitamin d459.5ALPP, SLC34A1, SPARC, FGF23, CYP19A1, IBSP
44thyroxine45 2410.4GH1, GNRH1, DIO1, DIO2, PRL, TRH
45testosterone45 60 11 2412.3AMH, GNRH1, GH1, PRL, CYP19A1, TRH
46arginine459.2GH1, GNRH1, GNAS, TRH, PRL, ADCY1
47progesterone45 60 29 11 2413.2GNRH1, GNAS, AMH, GH1, PRL, TRH
48heparin45 29 11 2412.0SPARC, FGF23, GH1, GNRH1, IBSP, ALPP
49dexamethasone45 50 29 1111.8SPARC, ALPP, CFD, LMOD1, TRH, PRL
50calcium45 50 11 2411.8FGF23, ADCY1, IBSP, ALPP, SPARC, SLC34A1

GO Terms for genes affiliated with Mccune Albright Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic to internal side of plasma membraneGO:0312349.8GNAS, GNA15, GNA11
2heterotrimeric G-protein complexGO:0058349.6GNAS, GNA11, GNA15
3extracellular spaceGO:0056159.4SPARC, FGF23, AMH, GNRH1, GH1, CFD
4extracellular regionGO:0055768.7SPARC, IBSP, AMH, GNAS, GNRH1, GH1

Biological processes related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1phosphate ion homeostasisGO:05506210.4SLC34A1, FGF23
2ovulation cycleGO:04269810.3GNRH1, PRL
3phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.2GNA11, GNA15
4response to lead ionGO:01028810.2SLC34A1, SPARC
5cAMP biosynthetic processGO:00617110.2ADCY1, GNAS
6thyroid hormone generationGO:00659010.2DIO2, DIO1
7female pregnancyGO:00756510.1PRL, GNRH1, GNAS
8hormone biosynthetic processGO:04244610.1DIO2, DIO1
9response to ethanolGO:0454719.9SPARC, TRH, PRL, GNRH1
10positive regulation of JAK-STAT cascadeGO:0464279.8PRL, GH1
11platelet activationGO:0301689.8GNA11, GNA15, CFD, SPARC
12response to drugGO:0424939.8AMH, GNAS, PRL, ADCY1
13blood coagulationGO:0075969.7SPARC, CFD, GNA15, GNAS, GNA11

Molecular functions related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1selenium bindingGO:00843010.2DIO2, DIO1
2thyroxine 5-deiodinase activityGO:00480010.1DIO2, DIO1
3G-protein beta/gamma-subunit complex bindingGO:0316839.9GNA11, GNAS, GNA15
4hormone activityGO:0051799.9PRL, GH1, GNRH1, AMH
5prolactin receptor bindingGO:0051489.8PRL, GH1

Products for genes affiliated with Mccune Albright Syndrome

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Sources for Mccune Albright Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet