MAS
MCID: MCC001
MIFTS: 76

Mccune Albright Syndrome (MAS) malady

Genetic diseases, Rare diseases, Reproductive diseases, Bone diseases, Skin diseases, Endocrine diseases, Fetal diseases, Cancer diseases categories
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Summaries for Mccune Albright Syndrome

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NIH Rare Diseases:42 Mccune-albright syndrome (mas) is a disease that affects the bones, skin, and several hormone-producing (endocrine) tissues. it is characterized by replacement of normal bone tissue with areas of abnormal fibrous growth (fibrous dysplasia); patches of abnormal skin coloring with jagged borders (cafe-au-lait spots); and abnormalities in the glands that regulate the body's rate of growth, sexual development, and other metabolic functions (multiple endocrine dysfunction). mas is caused by a change (mutation) in the gnas gene that occurs by chance very early in development. as a result, some of the body's cells have a normal version of the gnas gene, while other cells have the mutated version. this phenomenon is called mosaicism. the severity of mas and its features depend on the number and location of cells that have the mutated gnas gene. because mas occurs by chance, it is not inherited or passed down from one generation to the next. last updated: 12/26/2013

MalaCards based summary: Mccune Albright Syndrome, also known as polyostotic fibrous dysplasia, is related to fibrous dysplasia and acromegaly, and has symptoms including diffuse/generalised skin hyperpigmentation/melanoderma, cafe-au-lait spot and precocious puberty. An important gene associated with Mccune Albright Syndrome is GNAS (GNAS complex locus), and among its related pathways are Growth hormone receptor signaling and Nuclear signaling by ERBB4. The compounds quinagolide and ghrp have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and pituitary, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Disease Ontology:8 An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. it is caused by mutations in the gnas1 gene.

Genetics Home Reference:21 McCune-Albright syndrome is a disorder that affects the bones, skin, and several hormone-producing (endocrine) tissues.

Description from OMIM:46 174800

Aliases & Classifications for Mccune Albright Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 21Genetics Home Reference, 65Wikipedia, 9diseasecard, 20GeneTests, 22GTR, 44Novoseek, 57SNOMED-CT, 46OMIM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Mccune Albright Syndrome, Aliases & Descriptions:

Name: Mccune Albright Syndrome 8 42 10
Polyostotic Fibrous Dysplasia 8 65 21 48 62
Mccune-Albright Syndrome 9 21 48 62
Osteitis Fibrosa Disseminata 8 21 62
Mccune–albright Syndrome 65 20 22
Fibrous Dysplasia of Bone 8 48 62
Albright's Syndrome with Precocious Puberty 21 62
Albright-Sternberg Syndrome 21 62
Albright's Disease of Bone 21 62
Osteofibrous Dysplasia 48 62
Albright's Disease 42 21
Albright Syndrome 42 21
 
Pofd 42 21
Pfd 42 21
Mas 42 21
Fibrous Dysplasia with Pigmentary Skin Changes and Precocious Puberty 21
Gonadotropin-Independent Female-Limited Sexual Precocity 48
Albright-Mccune-Sternberg Syndrome 21
Fibrous Dysplasia, Polyostotic 21
Properdin Deficiency, X-Linked 62
Fibrous Dysplasia Polyostotic 44
Albright's Syndrome 21
Albright Syndrome 62


Classifications:



Characteristics (Orphanet epidemiological data):

48
mccune-albright syndrome:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Childhood; Age of death: Normal
fibrous dysplasia of bone:
Inheritance: Sporadic; Age of onset: Childhood; Age of death: Normal


External Ids:

Disease Ontology8 DOID:1858
OMIM46 174800
MeSH34 D005357
MESH via Orphanet35 D005359, D005357
ICD10 via Orphanet26 Q78.1
UMLS via Orphanet63 C0242292, C0016063, C0016065
ICD1025 M85.0, Q78.1

Related Diseases for Mccune Albright Syndrome

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Diseases related to Mccune Albright Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous dysplasia32.0FGF23, GNAS, GH1
2acromegaly31.8PRL, GH1
3precocious puberty31.4PRL, GNAS, GH1, GNRH1
4gigantism31.3GNAS, GH1, PRL
5ovarian cyst31.3GNAS, GNRH1
6hyperthyroidism31.2FGF23, GH1, PRL, GNAS
7acth-independent macronodular adrenal hyperplasia31.2GNAS
8carney complex31.1GNAS, PRKAR1A
9hypophosphatemia31.0FGF23, PTHLH
10hypogonadotropism31.0GNRH1, PRL
11ollier disease31.0PTHLH
12empty sella syndrome30.8GH1, PRL
13hypogonadism30.7GNRH1, PRL, GH1
14pseudohypoparathyroidism30.7GNAS, PTHLH, ADCY2
15cushing's syndrome30.7PRL, PRKAR1A
16adenoma30.6GNAS, GNRH1, PRL, GH1, PRKAR1A
17hyperparathyroidism30.6PRKAR1A, FGF23, PTHLH
18pituitary adenoma30.5GNAS, GNRH1, PRKAR1A, GH1, PRL
19infertility30.5FGF23, GNRH1, PRL
20thyroid adenoma30.5GNAS, PRKAR1A
21primary hyperparathyroidism30.5PTHLH, PRKAR1A, FGF23
22osteomalacia30.4GNAS, PTHLH, FGF23
23pituitary apoplexy30.4PRL, GNRH1
24amenorrhea30.3PRL, GNRH1
25hyperprolactinemia30.3GNRH1, GNAS, PTHLH, PRL, GH1
26hypercalcemia30.2PTHLH, FGF23, PRKAR1A
27osteoporosis30.0PTHLH, FGF23, GH1, PRKAR1A
28pituitary tumors29.8GNAS, GH1, PRKAR1A, PRL, GNRH1
29breast cancer29.5PRKAR1A, PRL, GH1, GNRH1, PTHLH
30prolactinoma29.4GH1, GNAS, GNRH1, PTHLH, PRL, PRKAR1A
31osteofibrous dysplasia11.1
32thyroiditis10.8
33osteitis fibrosa10.7
34forbes albright syndrome10.6
35osteosarcoma10.6
36rickets10.5
37neuropathy10.5
38testicular microlithiasis10.5
39somatostatin analog10.5
40mccune-albright syndrome, somatic, mosaic10.5
41cervicitis10.5
42hypoadrenalism10.5GH1
43growth hormone secreting pituitary adenoma10.4
44chondrosarcoma10.4
45pancreatitis10.4
46mazabraud syndrome10.4
47monostotic fibrous dysplasia10.4
48hepatitis10.4
49brachydactyly10.4GNAS
50turner syndrome10.4GNRH1

Graphical network of the top 20 diseases related to Mccune Albright Syndrome:



Diseases related to mccune albright syndrome

Symptoms for Mccune Albright Syndrome

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Clinical features from OMIM:

174800

Symptoms:

48 (show all 35)
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • cafe-au-lait spot
  • precocious puberty
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • dysostosis/chondrodysplasia/osteodysplasia/osteochondrosis/skeletal dysplasia
  • mutiple fractures/bone fragility
  • bone pain
  • hypophosphatemia
  • macrocephaly/macrocrania/megalocephaly/megacephaly
  • face/facial anomalies
  • prognathism/prognathia
  • dental malocclusion
  • anomalies of eyes and vision
  • optic nerve anomaly/optic atrophy/anomaly of the papilla
  • palate anomalies
  • anomalies of teeth and dentition
  • enamel anomaly
  • multiple caries
  • anomalies of ear and hearing
  • kyphosis
  • abnormal hepatic enzymes/transaminases
  • abnormal/polycystic ovaries
  • macropenis/megapenis/large penis
  • macroorchidism/macrotestes
  • goiter
  • hyperthyroidy
  • hyperparathyroidy
  • cortico-adrenal hyperplasia/hypersecretion
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • breast neoplasm/tumor/carcinoma/cancer
  • testicular/seminal neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • thyroid neoplasm/tumor/carcinoma/cancer
  • sarcoma
  • tall stature/gigantism/growth acceleration
  • cushingoid morphotype

HPO human phenotypes related to Mccune Albright Syndrome:

(show all 31)
id Description Frequency HPO Source Accession
1 precocious puberty hallmark (90%) HP:0000826
2 cafe-au-lait spot hallmark (90%) HP:0000957
3 hypophosphatemia hallmark (90%) HP:0002148
4 skeletal dysplasia hallmark (90%) HP:0002652
5 bone pain hallmark (90%) HP:0002653
6 recurrent fractures hallmark (90%) HP:0002757
7 reduced bone mineral density hallmark (90%) HP:0004349
8 generalized hyperpigmentation hallmark (90%) HP:0007440
9 enlarged penis occasional (7.5%) HP:0000040
10 macroorchidism occasional (7.5%) HP:0000053
11 tall stature occasional (7.5%) HP:0000098
12 polycystic ovaries occasional (7.5%) HP:0000147
13 abnormality of the palate occasional (7.5%) HP:0000174
14 macrocephaly occasional (7.5%) HP:0000256
15 mandibular prognathia occasional (7.5%) HP:0000303
16 hearing abnormality occasional (7.5%) HP:0000364
17 optic atrophy occasional (7.5%) HP:0000648
18 carious teeth occasional (7.5%) HP:0000670
19 abnormality of dental enamel occasional (7.5%) HP:0000682
20 dental malocclusion occasional (7.5%) HP:0000689
21 hyperthyroidism occasional (7.5%) HP:0000836
22 hyperparathyroidism occasional (7.5%) HP:0000843
23 goiter occasional (7.5%) HP:0000853
24 hypercortisolism occasional (7.5%) HP:0001578
25 abnormality of coagulation occasional (7.5%) HP:0001928
26 kyphosis occasional (7.5%) HP:0002808
27 elevated hepatic transaminases occasional (7.5%) HP:0002910
28 testicular neoplasm occasional (7.5%) HP:0010788
29 neoplasm of the breast occasional (7.5%) HP:0100013
30 neoplasm of the thyroid gland occasional (7.5%) HP:0100031
31 sarcoma occasional (7.5%) HP:0100242

Drugs & Therapeutics for Mccune Albright Syndrome

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Drug clinical trials:

Search ClinicalTrials for Mccune Albright Syndrome

Search NIH Clinical Center for Mccune Albright Syndrome

Genetic Tests for Mccune Albright Syndrome

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Genetic tests related to Mccune Albright Syndrome:

id Genetic test Affiliating Genes
1 Mccune-Albright Syndrome20 22 GNAS

Anatomical Context for Mccune Albright Syndrome

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MalaCards organs/tissues related to Mccune Albright Syndrome:

32
Bone, Skin, Pituitary, Thyroid, Breast, Ovary, Eye, Testes, Myeloid

Animal Models for Mccune Albright Syndrome or affiliated genes

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Publications for Mccune Albright Syndrome

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Articles related to Mccune Albright Syndrome:

(show top 50)    (show all 336)
idTitleAuthorsYear
1
Treatment protocols for growth hormone-secreting pituitary adenomas combined with craniofacial fibrous dysplasia: A case report of atypical McCune-Albright syndrome. (25120617)
2014
2
Three intragenic suppressors of a GTPase-deficient allele of GNAS associated with McCune-Albright syndrome. (24850831)
2014
3
Hepatobiliary and Pancreatic Neoplasms in Patients With McCune-Albright Syndrome. (24170100)
2014
4
Transsphenoidal approach for pituitary adenomas in patients with McCune-Albright syndrome. (22797802)
2013
5
Intragenic suppression of a constitutively active allele of GsI+ associated with McCune-Albright syndrome. (23288949)
2013
6
Oral manifestations of McCune-Albright syndrome. (23776876)
2013
7
Fulvestrant treatment of precocious puberty in girls with McCune-Albright syndrome. (22999294)
2012
8
Hansen's disease with McCune-Albright syndrome. (23326081)
2012
9
Primary bimorphic adrenocortical disease: cause of hypercortisolism in McCune-Albright syndrome. (21836496)
2011
10
Upper lip bite test in a patient with McCune Albright syndrome with acromegaly. (20036127)
2010
11
McCune-Albright Syndrome: intensely hypermetabolic polyostotic fibrous dysplasia on F-18 FDG-PET. (19851179)
2009
12
Oral rehabilitation with endosseous implants in a patient with fibrous dysplasia (McCune-Albright syndrome): a case report. (19022142)
2008
13
Combined treatment with ketoconazole and cyproterone acetate in a boy with McCune-Albright syndrome and peripheral precocious puberty. (18997496)
2008
14
McCune-Albright syndrome: 70 years of fascination and discovery. (17937058)
2007
15
The spectrum of McCune Albright syndrome. (17982388)
2007
16
McCune-Albright syndrome associated with acromegaly and bipolar affective disorder. (18054713)
2007
17
Clinical approach to clarifying the mechanism of abnormal bone metabolism in McCune-Albright syndrome. (16369891)
2006
18
McCune-Albright syndrome and acromegaly: effects of hypothalamopituitary radiotherapy and/or pegvisomant in somatostatin analog-resistant patients. (16984995)
2006
19
Unexpected mosaicism of R201H-GNAS1 mutant-bearing cells in the testes underlie macro-orchidism without sexual precocity in McCune-Albright syndrome. (17101633)
2006
20
Clinical presentation of McCune-Albright syndrome in males. (16789625)
2006
21
McCune-Albright syndrome: growth hormone and prolactin hypersecretion. (16789626)
2006
22
Pubertal development in patients with McCune-Albright syndrome or pseudohypoparathyroidism. (12729407)
2003
23
Lack of efficacy of fadrozole in treating precocious puberty in girls with the McCune-Albright syndrome. (14671160)
2003
24
McCune-Albright syndrome with thyrotoxicosis. (11564936)
2001
25
Infantile McCune-Albright syndrome. (11841638)
2001
26
Neurofibromatosis type 1 and McCune-Albright syndrome occurring in the same patient. (11122036)
2000
27
McCune-Albright syndrome associated with non-autoimmune type of hyperthyroidism with development of thyrotoxic crisis. (11150888)
2000
28
Meningioma associated with McCune-Albright syndrome. (10653317)
1999
29
Tamoxifen treatment of progressive precocious puberty in a patient with McCune-Albright syndrome. (10703542)
1999
30
Ketoconazole treatment of gonadotropin independent precocious puberty in girls with McCune-Albright syndrome: a preliminary report. (10392352)
1999
31
Chondrosarcoma in a patient with McCune-Albright syndrome. Report of a case. (10327499)
1999
32
Secondary central precocious puberty in a girl with McCune-Albright syndrome responds to treatment with GnRH analogue. (9642633)
1998
33
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation. (9403710)
1997
34
McCune-Albright syndrome (polyostotic fibrous dysplasia) with intracranial frontoethmoid mucocele. (9141412)
1997
35
Clinical implications of genetic defects in G proteins. The molecular basis of McCune-Albright syndrome and Albright hereditary osteodystrophy. (8699958)
1996
36
Growth hormone-prolactin-thyrotropin-secreting pituitary adenoma in atypical McCune-Albright syndrome with functionally normal Gs alpha protein. (7962285)
1994
37
Residents' corner. Answer to case of the month #12. McCune-Albright syndrome (polyostotic fibrous dysplasia). (1562893)
1992
38
Pathologic fracture of the femoral neck in a patient with McCune-Albright syndrome. (1608869)
1992
39
In vitro production of estradiol by ovarian granulosa cells in a case of McCune-Albright syndrome. (1865081)
1991
40
Hypersecretion of growth hormone and prolactin in McCune-Albright syndrome. (2498385)
1989
41
McCune-Albright syndrome with gigantism and hyperprolactinemia. (3680873)
1987
42
The McCune-Albright syndrome. (3545811)
1987
43
Value of bone scan in the McCune-Albright syndrome. Report of a case. (3812022)
1986
44
Autonomous ovarian hyperfunction followed by gonadotrophin-dependent puberty in McCune-Albright syndrome. (3085997)
1986
45
Testolactone treatment of precocious puberty in McCune-Albright syndrome. (3925675)
1985
46
McCune-Albright syndrome (fibrous dysplasia) associated with an orbital tumor. (6712072)
1984
47
Cyclical ovarian function resistant to treatment with an analogue of luteinizing hormone releasing hormone in McCune-Albright syndrome. (6434946)
1984
48
Hyperprolactinaemia in a patient with the McCune-Albright Syndrome. (571285)
1979
49
McCune-Albright syndrome with endocrinological investigations. Report of a case. (5410568)
1970
50
Sexual precocity in females; report of two cases, with arrest of precocity in the McCune-Albright syndrome after removal of a cystic ovary. (14891326)
1951

Variations for Mccune Albright Syndrome

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Clinvar genetic disease variations for Mccune Albright Syndrome:

6
id Gene Name Type Significance SNP ID Assembly Location
1GNASNM_001077488.2(GNAS): c.604C> G (p.Arg202Gly)single nucleotide variantPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420

Expression for genes affiliated with Mccune Albright Syndrome

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Expression patterns in normal tissues for genes affiliated with Mccune Albright Syndrome

Search GEO for disease gene expression data for Mccune Albright Syndrome.

Pathways for genes affiliated with Mccune Albright Syndrome

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Pathways related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GH1, PRL
2
Show member pathways
9.6PRL, GH1
39.6ADCY2, GNAS
49.6GNAS, ADCY2
59.6ADCY2, GNAS
69.6ADCY2, GNAS
79.6ADCY2, GNAS
89.6GNAS, ADCY2
99.4GH1, PTHLH
10
Show member pathways
9.3PRKAR1A, GNAS
119.3GNAS, PRKAR1A
129.2PRL, GH1, FGF23
13
Show member pathways
9.2FGF23, GH1, PRL
14
Show member pathways
9.2FGF23, ADCY2, GNAS
159.1PRKAR1A, ADCY2
16
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.1GNAS, GNRH1, ADCY2
179.0ADCY2, PTHLH, GNAS
18
Show member pathways
9.0ADCY2, PTHLH, GNAS
19
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.9GNAS, PRKAR1A, GH1
20
Show member pathways
8.8GNAS, ADCY2, PRKAR1A
21
Show member pathways
8.8GNAS, ADCY2, PRKAR1A
22
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
8.8GNAS, ADCY2, PRKAR1A
238.8GNAS, ADCY2, PRKAR1A
24
Show member pathways
Signal transduction cAMP signaling60
8.8PRKAR1A, ADCY2, GNAS
25
Show member pathways
8.8PRKAR1A, ADCY2, GNAS
26
Show member pathways
8.8PRKAR1A, ADCY2, GNAS
27
Show member pathways
Calcium Regulation in the Cardiac Cell37
8.8PRKAR1A, ADCY2, GNAS
28
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
8.8PRKAR1A, ADCY2, GNAS
29
Show member pathways
8.8FGF23, PRKAR1A, ADCY2
30
Show member pathways
8.7ADCY2, PRKAR1A, GH1
31
Show member pathways
8.7GNRH1, PRL, GH1, FGF23
328.7GNAS, PTHLH, PRKAR1A
33
Show member pathways
8.6FGF23, GH1, ADCY2, GNRH1
34
Show member pathways
8.6PRKAR1A, ADCY2, GNRH1
35
Show member pathways
8.6PRKAR1A, ADCY2, GNRH1
36
Show member pathways
8.4GNAS, ADCY2, PRKAR1A, FGF23
37
Show member pathways
8.3GNRH1, PRKAR1A, GH1, FGF23
38
Show member pathways
8.3FGF23, GH1, PRKAR1A, GNRH1
398.3ADCY2, PRL, PRKAR1A, FGF23
40
Show member pathways
7.9ADCY2, PRL, PRKAR1A, GH1, FGF23
41
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
42
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
43
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
44
Show member pathways
7.8FGF23, GH1, PRKAR1A, ADCY2, GNRH1
45
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
46
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
47
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
48
Show member pathways
7.6GNAS, GNRH1, PTHLH, ADCY2, PRL, GH1
49
Show member pathways
6.4FGF23, GNAS, GNRH1, PTHLH, ADCY2, PRL

Compounds for genes affiliated with Mccune Albright Syndrome

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Compounds related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1quinagolide4410.0PRL, GH1
2ghrp449.8GH1, PRL
3estradiol benzoate449.7GNRH1, PRL
4leuprolide44 61 28 1112.7GNRH1, PRL
55-hydroxytryptophan449.7GH1, PRL
6adenosine 3,5-cyclic monophosphorothioate449.7PTHLH, GNRH1
7mhpg449.6GNRH1, PRL
8hexarelin44 2810.6PRL, GH1
9lanreotide44 2810.6PRL, GH1
10leuprolide acetate449.5GNRH1, PRL, GH1
11clomiphene citrate449.5PRL, GNRH1, GH1
12pyridostigmine44 1110.5GH1, PRL
13naltrexone44 28 50 1112.5GNRH1, PRL, GH1
14cabergoline44 28 1111.5GH1, PRL, GNRH1
15metoclopramide44 50 1111.5GH1, GNRH1, PRL
16bromocriptine44 28 1111.5GNRH1, GH1, PRL
17naloxone44 28 50 1112.5PRL, GNRH1, GH1
18dehydroepiandrosterone sulfate449.5PRL, GNRH1, GH1
19opiate449.5GH1, GNRH1, PRL
20androstenedione44 2410.4GH1, GNRH1, PRL
21estrone44 28 24 1112.4GH1, GNRH1, PRL
221,25 dihydroxy vitamin d3449.4FGF23, GH1, PTHLH
23sulpiride44 28 1111.3PRL, GH1
24hydrocortisone44 2 61 1112.3GH1, PRL, PTHLH
25progestin449.2GNRH1, PRL, PTHLH
26verapamil44 28 50 24 1113.2GNRH1, PTHLH, GH1
27nifedipine44 28 50 1112.2GH1, PTHLH, GNRH1
28acth449.1GH1, PRL, GNAS, GNRH1
29gnrh449.1GH1, PRL, GNRH1, GNAS
30dihydrotestosterone44 28 24 1111.9GH1, PTHLH, PRL, GNRH1
31thyroxine44 249.9GH1, PRL, PTHLH, GNRH1
32creatinine448.9FGF23, GH1, GNRH1, PTHLH
33tamoxifen44 50 28 1111.8GH1, PRL, PTHLH, GNRH1
34heparin44 28 24 1111.8GNRH1, FGF23, GH1, PTHLH
35estradiol44 24 1110.8GNRH1, PTHLH, PRL, GH1
36dopamine44 28 24 1111.7PRL, GNAS, GNRH1, ADCY2, GH1
37vitamin d448.6PRKAR1A, GH1, FGF23, PTHLH
38testosterone44 61 24 1111.6GH1, PRL, PTHLH, GNRH1
39ribonucleic acid448.6GNRH1, GNAS, GH1, PRL, PTHLH
40norepinephrine44 24 1110.6PTHLH, GNRH1, GNAS, PRL, GH1
41progesterone44 28 61 24 1112.5GH1, GNRH1, GNAS, PTHLH, PRL
42isoproterenol44 119.5ADCY2, PTHLH, GNRH1, GNAS, GH1
43cyclic amp44 249.4GNAS, PRKAR1A, ADCY2, PTHLH
44octreotide44 61 28 1111.2PTHLH, PRL, GNRH1, GNAS, GH1, FGF23
45forskolin44 50 1110.2GH1, PRKAR1A, ADCY2, PTHLH, GNAS
46glucose448.2PRL, GNAS, PTHLH, PRKAR1A, GH1
47dexamethasone44 50 28 1111.0PRKAR1A, GNRH1, PRL, PTHLH, GH1
48steroid447.7PRL, PRKAR1A, GH1, PTHLH, GNAS, GNRH1
49adenylate447.7GNRH1, ADCY2, PRKAR1A, GH1, GNAS, PTHLH
50arginine447.4GNAS, GNRH1, PRL, PRKAR1A, GH1, FGF23

GO Terms for genes affiliated with Mccune Albright Syndrome

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Cellular components related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5FGF23, GH1, PTHLH, GNRH1
2extracellular regionGO:0055767.4FGF23, GNAS, GNRH1, PTHLH, PRL, GH1

Biological processes related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1cAMP biosynthetic processGO:0061719.9ADCY2, GNAS
2positive regulation of JAK-STAT cascadeGO:0464279.9GH1, PRL
3JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.8GH1, PRL
4endochondral ossificationGO:0019589.6PTHLH, GNAS
5positive regulation of cAMP biosynthetic processGO:0308199.5PTHLH, GNAS
6activation of protein kinase A activityGO:0341999.3PRKAR1A, ADCY2
7regulation of insulin secretionGO:0507969.3PRKAR1A, GNAS
8adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.3GNAS, PTHLH, ADCY2
9regulation of gene expressionGO:0104689.2PTHLH, GNRH1
10cellular response to glucagon stimulusGO:0713779.1GNAS, ADCY2, PRKAR1A
11water transportGO:0068339.1GNAS, ADCY2, PRKAR1A
12energy reserve metabolic processGO:0061129.1GNAS, ADCY2, PRKAR1A
13fibroblast growth factor receptor signaling pathwayGO:0085439.0ADCY2, PRKAR1A, FGF23
14epidermal growth factor receptor signaling pathwayGO:0071738.9ADCY2, PRKAR1A, FGF23
15female pregnancyGO:0075658.8PRL, PTHLH, GNRH1, GNAS
16activation of phospholipase C activityGO:0072028.8PRKAR1A, ADCY2
17neurotrophin TRK receptor signaling pathwayGO:0480118.8ADCY2, PRKAR1A, FGF23

Molecular functions related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein beta/gamma-subunit complex bindingGO:0316839.6ADCY2, GNAS
2prolactin receptor bindingGO:0051489.5PRL, GH1
3adenylate cyclase activityGO:0040169.3ADCY2, GNAS
4hormone activityGO:0051798.5GH1, PRL, PTHLH, GNRH1

Products for genes affiliated with Mccune Albright Syndrome

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Sources for Mccune Albright Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet