MAS
MCID: MCC001
MIFTS: 82

Mccune Albright Syndrome (MAS) malady

Reproductive diseases, Bone diseases, Skin diseases, Endocrine diseases, Fetal diseases, Cancer diseases categories

Summaries for Mccune Albright Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Mccune-albright syndrome (mas) is a disease that affects the bones, skin, and several hormone-producing (endocrine) tissues. it is characterized by replacement of normal bone tissue with areas of abnormal fibrous growth (fibrous dysplasia); patches of abnormal skin coloring with jagged borders (cafe-au-lait spots); and abnormalities in the glands that regulate the body's rate of growth, sexual development, and other metabolic functions (multiple endocrine dysfunction). mas is caused by a change (mutation) in the gnas gene that occurs by chance very early in development. as a result, some of the body's cells have a normal version of the gnas gene, while other cells have the mutated version. this phenomenon is called mosaicism. the severity of mas and its features depend on the number and location of cells that have the mutated gnas gene. because mas occurs by chance, it is not inherited or passed down from one generation to the next. last updated: 12/26/2013

MalaCards: Mccune Albright Syndrome, also known as mccune-albright syndrome, is related to fibrous dysplasia and acromegaly, and has symptoms including goiter, hyperthyroidy and hyperparathyroidy. An important gene associated with Mccune Albright Syndrome is GNAS (GNAS complex locus), and among its related pathways are Osteoblast Signaling and Regulation of Insulin Secretion by Free Fatty Acids. The compounds forskolin and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and pituitary, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Disease Ontology:8 An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. it is caused by mutations in the gnas1 gene.

Genetics Home Reference:21 McCune-Albright syndrome is a disorder that affects the bones, skin, and several hormone-producing (endocrine) tissues.

Description from OMIM:46 174800

Aliases & Classifications for Mccune Albright Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 21Genetics Home Reference, 60UMLS, 9diseasecard, 20GeneTests, 22GTR, 46OMIM, 44Novoseek, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

48
mccune-albright syndrome:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Childhood; Age of death: Normal
fibrous dysplasia of bone:
Inheritance: Sporadic; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

mccune albright syndrome 8 42 10
mccune-albright syndrome 9 20 22 21 46 48 60
polyostotic fibrous dysplasia 8 21 48 60
osteitis fibrosa disseminata 8 21 60
fibrous dysplasia of bone 8 48
osteofibrous dysplasia 48 60
albright's disease 42 21
albright syndrome 42 21
pofd 42 21
mas 42 21
pfd 42 21
fibrous dysplasia with pigmentary skin changes and precocious puberty 21
gonadotropin-independent female-limited sexual precocity 48
albright's syndrome with precocious puberty 21
albright-mccune-sternberg syndrome 21
fibrous dysplasia, polyostotic 21
properdin deficiency, x-linked 60
fibrous dysplasia polyostotic 44
albright-sternberg syndrome 21
albright's disease of bone 21
jaffe-lichtenstein disease 48
albright's syndrome 21


External Ids:

Disease Ontology8 DOID:1858
OMIM46 174800
MeSH34 D005357
MESH via Orphanet35 D005359, D005357
ICD10 via Orphanet26 Q78.1
SNOMED-CT via Orphanet57 36517007, 10623005
UMLS via Orphanet61 C0242292, C0016065
ICD1025 M85.0, Q78.1

Related Diseases for Mccune Albright Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Mccune Albright Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous dysplasia31.6GNAS, GNA11, IBSP, GNA15, GH1, FGF23
2acromegaly31.3GH1, PRL
3hyperthyroidism31.1ALPP, LMOD1, FGF23, TRH, PRL, GH1
4pituitary adenoma31.0GNAS, GNRH1, MEN1, GH1, PRL, TRH
5adenoma31.0GNAS, GNRH1, DIO2, MEN1, GH1, PRL
6thyroiditis31.0TRH
7osteitis fibrosa30.9GNAS, ALPP
8carney complex30.8MEN1, GNAS
9ovarian cyst30.8GNAS, GNRH1, CYP19A1
10osteosarcoma30.8ALPP, SPARC, IBSP
11rickets30.7FGF23, ALPP
12osteofibrous dysplasia30.7SPARC, GNAS
13hypophosphatemia30.7FGF23, SLC34A1, ALPP
14hyperparathyroidism30.7ALPP, FGF23, MEN1
15hyperprolactinemia30.7TRH, PRL, GH1, GNRH1, GNAS
16hypogonadotropism30.5PRL, GNRH1
17pseudohypoparathyroidism30.5GNA15, GNAS, GNA11
18primary hyperparathyroidism30.5IBSP, MEN1, FGF23, ALPP
19hypogonadism30.5GNRH1, GH1, PRL, TRH, CYP19A1
20cushing's syndrome30.5GNAS, GNRH1, MEN1, GH1, PRL, TRH
21thyrotoxicosis30.3TRH
22pancreatitis30.3ALPP
23empty sella syndrome30.3GH1, PRL
24paget's disease of bone30.3ALPP
25hypercalcemia30.3ALPP, FGF23, MEN1
26osteogenesis imperfecta30.3ALPP, SPARC, IBSP
27gigantism30.3GNAS, GH1, PRL
28bone carcinoma30.3IBSP, SPARC, ALPP
29goiter30.3GNAS, DIO2, TRH, LMOD1
30infertility30.3FGF23, CYP19A1, PRL, GNRH1, AMH
31meningioma30.3SPARC, MEN1
32osteoporosis30.3ALPP, SPARC, FGF23, CYP19A1, GH1, IBSP
33prolactinoma30.3TRH, PRL, GH1, MEN1, GNRH1, GNAS
34breast cancer30.3AMH, GNRH1, MEN1, GH1, PRL, CYP19A1
35osteomalacia30.2ALPP, FGF23, GNAS
36pituitary apoplexy29.9GNRH1, PRL, TRH
37amenorrhea29.9AMH, GNRH1, PRL, TRH
38adenocarcinoma29.8IBSP, DIO2, MEN1, SPARC
39polycystic ovary syndrome29.8GNRH1, GH1, PRL, CYP19A1
40obesity29.7GNAS, DIO2, GH1, TRH, CFD
41image syndrome10.6
42long bone adamantinoma10.5
43cervicitis10.5
44adult syndrome10.5
45forbes albright syndrome10.4
46hepatitis10.4
47mccune–albright syndrome10.4
48growth hormone secreting pituitary adenoma10.4
49chondrosarcoma10.4
50neuropathy10.4

Graphical network of the top 20 diseases related to Mccune Albright Syndrome:



Diseases related to mccune albright syndrome

Clinical Features for Mccune Albright Syndrome

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46OMIM, 48Orphanet
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Clinical features from OMIM:

174800

Clinical synopsis from OMIM:

174800

Symptoms:

48 (show all 35)
  • goiter
  • hyperthyroidy
  • hyperparathyroidy
  • cortico-adrenal hyperplasia/hypersecretion
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • breast neoplasm/tumor/carcinoma/cancer
  • testicular/seminal neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • thyroid neoplasm/tumor/carcinoma/cancer
  • sarcoma
  • tall stature/gigantism/growth acceleration
  • cushingoid morphotype
  • mutiple fractures/bone fragility
  • macroorchidism/macrotestes
  • macropenis/megapenis/large penis
  • abnormal/polycystic ovaries
  • face/facial anomalies
  • macrocephaly/macrocrania/megalocephaly/megacephaly
  • hypophosphatemia
  • bone pain
  • dysostosis/chondrodysplasia/osteodysplasia/osteochondrosis/skeletal dysplasia
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • precocious puberty
  • cafe-au-lait spot
  • prognathism/prognathia
  • dental malocclusion
  • anomalies of eyes and vision
  • abnormal hepatic enzymes/transaminases
  • kyphosis
  • anomalies of ear and hearing
  • multiple caries
  • enamel anomaly
  • anomalies of teeth and dentition
  • palate anomalies
  • optic nerve anomaly/optic atrophy/anomaly of the papilla
  • diffuse/generalised skin hyperpigmentation/melanoderma

Drugs & Therapeutics for Mccune Albright Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mccune Albright Syndrome

Drug clinical trials:

Search ClinicalTrials for Mccune Albright Syndrome

Search NIH Clinical Center for Mccune Albright Syndrome

Search CenterWatch for Mccune Albright Syndrome

Genetic Tests for Mccune Albright Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Mccune Albright Syndrome:

id Genetic test Affiliating Genes
1 Mccune-Albright Syndrome20 22 GNAS

Anatomical Context for Mccune Albright Syndrome

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32MalaCards
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MalaCards organs/tissues related to Mccune Albright Syndrome:

32
Bone, Skin, Pituitary, Thyroid, Ovary, Breast, Eye, Testes, Myeloid

Animal Models for Mccune Albright Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mccune Albright Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.0AMH, GNA11, DIO1, MEN1
2MP:00053679.4GNA11, GNAS, GNRH1, DIO1, DIO2, FGF23
3MP:00053709.3GNA11, GNAS, GNRH1, MEN1, GH1, PRL
4MP:00053909.2IBSP, GNA11, GNAS, GNRH1, CYP19A1, FGF23
5MP:00053899.1AMH, GNRH1, MEN1, GH1, PRL, CYP19A1
6MP:00107718.9GNA11, GNAS, GNRH1, PRL, CYP19A1, FGF23
7MP:00036318.8GNAS, GNRH1, MEN1, GH1, PRL, TRH
8MP:00053878.7GNA11, GNAS, GNRH1, MEN1, PRL, CYP19A1
9MP:00053788.4IBSP, GNA11, GNAS, GNRH1, DIO1, DIO2
10MP:00053768.0ADCY1, AMH, GNA11, GNAS, GNRH1, DIO1

Publications for Mccune Albright Syndrome

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50PubMed
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Articles related to Mccune Albright Syndrome:

(show top 50)    (show all 329)
idTitleAuthorsYear
1
Quantitative and sensitive detection of GNAS mutations causing mccune-albright syndrome with next generation sequencing. (23536913)
2013
2
Sinonasal disease in polyostotic fibrous dysplasia and McCune-Albright Syndrome. (23444264)
2013
3
Fulvestrant treatment of precocious puberty in girls with McCune-Albright syndrome. (22999294)
2012
4
Primary bimorphic adrenocortical disease: cause of hypercortisolism in McCune-Albright syndrome. (21836496)
2011
5
Polyostotic fibrous dysplasia with gigantism and huge pelvic tumor: a rare case of McCune-Albright syndrome. (20878436)
2011
6
Upper lip bite test in a patient with McCune Albright syndrome with acromegaly. (20036127)
2010
7
Unusual phenotypical variations in a boy with McCune-Albright syndrome. (20197676)
2010
8
Massive allograft of the tibia for a child with McCune-Albright syndrome: case presentation and surgical intervention. (19949350)
2010
9
McCune-Albright Syndrome: intensely hypermetabolic polyostotic fibrous dysplasia on F-18 FDG-PET. (19851179)
2009
10
Craniofacial fibrous dysplasia associated with McCune-Albright syndrome. (19231793)
2009
11
Severe arterial hypertension: a possible complication of McCune-Albright syndrome. (18958498)
2009
12
McCune-Albright syndrome in a discordant monozygotic twin. (19697584)
2009
13
Evolving diagnosis of McCune-Albright syndrome. atypical presentation and follow up. (19554813)
2009
14
Combined treatment with ketoconazole and cyproterone acetate in a boy with McCune-Albright syndrome and peripheral precocious puberty. (18997496)
2008
15
The role of type 1 and type 2 5'-deiodinase in the pathophysiology of the 3,5,3'-triiodothyronine toxicosis of McCune-Albright syndrome. (18349068)
2008
16
McCune-Albright syndrome. (18489744)
2008
17
McCune-Albright syndrome: 70 years of fascination and discovery. (17937058)
2007
18
Near-total mandible reconstruction with a single fibula flap containing fibrous dysplasia in McCune Albright Syndrome. (17993908)
2007
19
McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamping method. (17878646)
2007
20
Clinical presentation of McCune-Albright syndrome in males. (16789625)
2006
21
McCune-Albright syndrome: growth hormone and prolactin hypersecretion. (16789626)
2006
22
Parental origin of Gsalpha mutations in the McCune-Albright syndrome and in isolated endocrine tumors. (15181091)
2004
23
A novel technique based on a PNA hybridization probe and FRET principle for quantification of mutant genotype in fibrous dysplasia/McCune-Albright syndrome. (15096559)
2004
24
McCune Albright Syndrome (MCAS): a case series. (12554915)
2003
25
Tamoxifen treatment for precocious puberty in McCune-Albright syndrome: a multicenter trial. (12915825)
2003
26
Is McCune-Albright syndrome overlooked in subjects with fibrous dysplasia of bone? (12756386)
2003
27
Surgical treatment of fibrous dysplasia of bone in McCune-Albright syndrome. (12199353)
2002
28
Bone turnover in children and adolescents with McCune-Albright syndrome treated with pamidronate for bone fibrous dysplasia. (12200645)
2002
29
Impact of endocrine hyperfunction and phosphate wasting on bone in McCune-Albright syndrome. (12199350)
2002
30
Infantile McCune-Albright syndrome. (11841638)
2001
31
McCune-Albright syndrome: growth hormone dynamics in pregnancy. (11397839)
2001
32
Dynamics of ovarian function in an adult woman with McCune--Albright syndrome. (11397863)
2001
33
Hypophosphatemic rickets accompanying McCune-Albright syndrome: evidence that a humoral factor causes hypophosphatemia. (11498730)
2001
34
Macroorchidism due to autonomous hyperfunction of Sertoli cells and G(s)alpha gene mutation: an unusual expression of McCune-Albright syndrome in a prepubertal boy. (11297617)
2001
35
Clinical implications of genetic defects in G proteins: oncogenic mutations in G alpha s as the molecular basis for the McCune-Albright syndrome. (10714367)
1999
36
Secondary central precocious puberty in a girl with McCune-Albright syndrome responds to treatment with GnRH analogue. (9642633)
1998
37
Breast Cancer in a Patient with McCune-Albright Syndrome. (11091644)
1998
38
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation. (9403710)
1997
39
Polyostotic fibrous dysplasia in McCune-Albright syndrome diagnosed by bone scintigraphy. (9193821)
1997
40
Thyroid sonographic abnormalities in McCune-Albright syndrome. (8657483)
1996
41
Gs alpha mutation at codon 201 in pituitary adenoma causing gigantism in a 6-year-old boy with McCune-Albright syndrome. (8923825)
1996
42
Urinary cyclic adenosine 3',5'-monophosphate response in McCune-Albright syndrome: clinical evidence for altered renal adenylate cyclase activity. (8530601)
1995
43
McCune-Albright syndrome and acromegaly: clinical studies and responses to treatment in five cases. (7921205)
1994
44
McCune-Albright syndrome: the patterns of scintigraphic abnormalities. (2395015)
1990
45
Pituitary adenoma in McCune-Albright syndrome: MR demonstration. (2745790)
1989
46
Acromegaly and hyperthyroidism associated with McCune-Albright syndrome. (3220461)
1988
47
Estrogen receptors in bone in a patient with polyostotic fibrous dysplasia (McCune-Albright syndrome). (3398893)
1988
48
Ovarian function in girls with McCune-Albright syndrome. (3092175)
1986
49
McCune-Albright syndrome in a male child: a clinical and endocrinologic enigma. (340627)
1978
50
The McCune-Albright syndrome. (901347)
1977

Genetic Variations for Mccune Albright Syndrome

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Mccune Albright Syndrome:

62
id Symbol AA change Variation ID SNP ID
1GNASp.Arg201HisVAR_003441
2GNASp.Arg201CysVAR_003442rs11554273
3GNASp.Arg201GlyVAR_017844

Expression for genes affiliated with Mccune Albright Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mccune Albright Syndrome

Search GEO for disease gene expression data for Mccune Albright Syndrome.

Pathways for genes affiliated with Mccune Albright Syndrome

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37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG, 49PharmGKB, 51QIAGEN
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Pathways related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2FGF23, IBSP
2
Hide members
10.0GNA15, GNA11
3
Development A2B receptor- action via G-protein alpha s
Hide members
9.9GNA11, GNAS, ADCY1
49.9GNAS, CYP19A1, ADCY1
59.9GNA15, GNAS, GNA11
69.8GNA11, GNA15, ADCY1
7
Development A3 receptor signaling
Hide members
9.8GNA11, GNA15, ADCY1
8
Hide members
9.8ADCY1, GNA15, GNA11
9
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
9.8IBSP, GNA11, GNAS, ADCY1
10
Development Endothelin-1/EDNRA signaling
Hide members
9.7GNA11, GNAS, GNRH1, ADCY1
11
Hide members
9.7ADCY1, GNA15, GNAS, GNA11
129.7ADCY1, GNA15, GNAS, GNA11
13
Development Dopamine D2 receptor transactivation of EGFR
Hide members
9.7GNA11, GNAS, GNA15, ADCY1
14
Hide members
9.7GNA11, GNAS, GNA15, ADCY1
159.7ADCY1, GNA15, GNAS, GNA11
16
Signal transduction cAMP signaling
Hide members
9.7GNA11, GNAS, GNA15, ADCY1
17
Hide members
9.6TRH, GNA15, GNRH1, GNA11
18
Hide members
9.5GNA11, GNRH1, GNA15, GH1, FGF23
19
Hide members
9.4GNAS, GNRH1, GH1, PRL, TRH, ADCY1
20
Hide members
9.4GNA11, GNRH1, GNA15, GH1, PRL, FGF23
21
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
22
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
23
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
24
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
25
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
26
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
27
Hide members
9.3GNA11, GNRH1, GNA15, GH1, FGF23, ADCY1
28
Hide members
8.4ADCY1, IBSP, GNA11, GNAS, GNRH1, GNA15

Compounds for genes affiliated with Mccune Albright Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 24HMDB, 59Tocris Bioscience
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Compounds related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1forskolin44 49 1112.6IBSP
2procollagen4410.4ALPP
31,25 dihydroxy vitamin d34410.4IBSP, FGF23, SLC34A1
4estrogen4410.3LMOD1, TRH, DIO2
5bromocriptine28 44 1112.2GNRH1, PRL, TRH
6estradiol benzoate4410.2GNRH1, PRL, CYP19A1
7ghrp4410.2GH1, TRH, PRL
8leuprolide acetate4410.2PRL, GNRH1, GH1, CYP19A1
9clomiphene citrate4410.2GNRH1, CYP19A1, GH1, PRL
10alizarin4410.2SPARC, IBSP, ALPP
11pyridostigmine44 1111.1PRL, TRH, GH1
12metoclopramide44 1111.1GH1, PRL, GNRH1, TRH
13sulpiride44 28 1112.1PRL, TRH, GH1
14zoledronic acid4410.1CYP19A1, IBSP, GNRH1, ALPP
15dehydroepiandrosterone sulfate4410.1CYP19A1, PRL, GH1, GNRH1
16propylthiouracil44 2 1112.1LMOD1, ALPP, DIO2
17pyridinoline4410.1GH1, SPARC, IBSP, ALPP
18naloxone44 49 28 1113.1TRH, GNRH1, PRL, GH1
19buserelin44 28 1112.1PRL, GNRH1, CYP19A1
20iodine44 2411.0DIO2, GNAS, TRH, LMOD1, DIO1
21melatonin44 59 28 11 2414.0CYP19A1, PRL, GH1, IBSP, TRH
22naltrexone44 49 28 1113.0GH1, PRL, GNRH1
23hydroxyapatite449.9FGF23, SPARC, ALPP, IBSP
24toremifene44 1110.9CYP19A1, PRL, GNRH1
25octreotide44 59 28 1112.9GNAS, GNRH1, GH1, PRL, TRH, FGF23
26androstenedione44 2410.9GH1, CYP19A1, PRL, GNRH1
27hydrocortisone44 2 59 1112.9TRH, PRL, ALPP, GH1, CYP19A1
28triiodothyronine449.8DIO1, LMOD1, TRH, PRL, GH1, DIO2
29calcitriol44 59 11 2412.8SPARC, SLC34A1, GH1, FGF23, ALPP
30gnrh449.8GH1, GNRH1, TRH, GNAS, CYP19A1, PRL
31acth449.8GNAS, TRH, GH1, PRL, ADCY1, GNRH1
32tamoxifen44 49 28 1112.8PRL, ALPP, GNRH1, AMH, GH1, CYP19A1
33progestin449.8ALPP, CYP19A1, PRL, GNRH1
34dopamine44 28 11 2412.8DIO2, GNAS, ADCY1, LMOD1, TRH, GNRH1
35creatinine449.7ADCY1, GNRH1, FGF23, CFD, ALPP, IBSP
36ibmx44 28 5911.7GH1, TRH, CFD, ALPP, ADCY1, IBSP
37cysteine449.7SPARC, LMOD1, DIO2, GNAS, DIO1, IBSP
38norepinephrine44 11 2411.7GNRH1, PRL, GNAS, TRH, ALPP, GH1
39estradiol44 11 2411.7GNRH1, GH1, PRL, TRH, AMH, CYP19A1
40ribonucleic acid449.6PRL, GNRH1, GNAS, DIO2, GH1
41thymidine44 2410.5IBSP, GNAS, GH1, ALPP, TRH, SPARC
42steroid449.5SPARC, IBSP, CYP19A1, GNAS, GNRH1, PRL
43vitamin d449.5ALPP, SLC34A1, SPARC, FGF23, CYP19A1, IBSP
44thyroxine44 2410.4GH1, GNRH1, DIO1, DIO2, PRL, TRH
45testosterone44 59 11 2412.3AMH, GNRH1, GH1, PRL, CYP19A1, TRH
46arginine449.2GH1, GNRH1, GNAS, TRH, PRL, ADCY1
47progesterone44 59 28 11 2413.2GNRH1, GNAS, AMH, GH1, PRL, TRH
48heparin44 28 11 2412.0SPARC, FGF23, GH1, GNRH1, IBSP, ALPP
49dexamethasone44 49 28 1111.8SPARC, ALPP, CFD, LMOD1, TRH, PRL
50calcium44 49 11 2411.8FGF23, ADCY1, IBSP, ALPP, SPARC, SLC34A1

GO Terms for genes affiliated with Mccune Albright Syndrome

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16Gene Ontology
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Cellular components related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic to internal side of plasma membraneGO:0312349.8GNA11, GNAS, GNA15
2heterotrimeric G-protein complexGO:0058349.6GNA15, GNAS, GNA11
3extracellular spaceGO:0056159.4GNRH1, GH1, FGF23, CFD, SPARC, AMH
4extracellular regionGO:0055768.7SPARC, IBSP, AMH, GNAS, GNRH1, GH1

Biological processes related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1phosphate ion homeostasisGO:05506210.4SLC34A1, FGF23
2ovulation cycleGO:04269810.3GNRH1, PRL
3phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.2GNA11, GNA15
4response to lead ionGO:01028810.2SLC34A1, SPARC
5cAMP biosynthetic processGO:00617110.2ADCY1, GNAS
6thyroid hormone generationGO:00659010.2DIO2, DIO1
7female pregnancyGO:00756510.1PRL, GNRH1, GNAS
8hormone biosynthetic processGO:04244610.1DIO2, DIO1
9response to ethanolGO:0454719.9SPARC, TRH, PRL, GNRH1
10positive regulation of JAK-STAT cascadeGO:0464279.8PRL, GH1
11platelet activationGO:0301689.8GNA11, GNA15, CFD, SPARC
12response to drugGO:0424939.8AMH, GNAS, PRL, ADCY1
13blood coagulationGO:0075969.7SPARC, CFD, GNA15, GNAS, GNA11

Molecular functions related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1selenium bindingGO:00843010.2DIO2, DIO1
2thyroxine 5-deiodinase activityGO:00480010.1DIO2, DIO1
3G-protein beta/gamma-subunit complex bindingGO:0316839.9GNA11, GNAS, GNA15
4hormone activityGO:0051799.9PRL, GH1, GNRH1, AMH
5prolactin receptor bindingGO:0051489.8PRL, GH1

Products for genes affiliated with Mccune Albright Syndrome

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  • Antibodies
  • Proteins
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Sources for Mccune Albright Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet