MAS
MCID: MCC001
MIFTS: 76

Mccune Albright Syndrome (MAS) malady

Genetic diseases, Rare diseases, Reproductive diseases, Bone diseases, Skin diseases, Endocrine diseases, Fetal diseases, Cancer diseases categories

Summaries for Mccune Albright Syndrome

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9Disease Ontology, 22Genetics Home Reference, 44NIH Rare Diseases, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Mccune-albright syndrome (mas) is a disease that affects the bones, skin, and several hormone-producing (endocrine) tissues. it is characterized by replacement of normal bone tissue with areas of abnormal fibrous growth (fibrous dysplasia); patches of abnormal skin coloring with jagged borders (cafe-au-lait spots); and abnormalities in the glands that regulate the body's rate of growth, sexual development, and other metabolic functions (multiple endocrine dysfunction). mas is caused by a change (mutation) in the gnas gene that occurs by chance very early in development. as a result, some of the body's cells have a normal version of the gnas gene, while other cells have the mutated version. this phenomenon is called mosaicism. the severity of mas and its features depend on the number and location of cells that have the mutated gnas gene. because mas occurs by chance, it is not inherited or passed down from one generation to the next. last updated: 12/26/2013

MalaCards: Mccune Albright Syndrome, also known as polyostotic fibrous dysplasia, is related to fibrous dysplasia and acromegaly, and has symptoms including bone pain, macropenis/megapenis/large penis and hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding. An important gene associated with Mccune Albright Syndrome is GNAS (GNAS complex locus), and among its related pathways are Growth hormone receptor signaling and Nuclear signaling by ERBB4. The compounds quinagolide and ghrp have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and pituitary, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Disease Ontology:9 An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. it is caused by mutations in the gnas1 gene.

Genetics Home Reference:22 McCune-Albright syndrome is a disorder that affects the bones, skin, and several hormone-producing (endocrine) tissues.

Description from OMIM:48 174800

Aliases & Classifications for Mccune Albright Syndrome

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9Disease Ontology, 10diseasecard, 66Wikipedia, 44NIH Rare Diseases, 21GeneTests, 23GTR, 22Genetics Home Reference, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 36MeSH, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

50
mccune-albright syndrome:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Childhood; Age of death: Normal
fibrous dysplasia of bone:
Inheritance: Sporadic; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

mccune albright syndrome 9 44 11
polyostotic fibrous dysplasia 9 66 22 50 63
mccune-albright syndrome 10 22 48 50 63
osteitis fibrosa disseminata 9 22 63
mccuneā€“albright syndrome 66 21 23
fibrous dysplasia of bone 9 50
osteofibrous dysplasia 50 63
albright's disease 44 22
albright syndrome 44 22
pofd 44 22
mas 44 22
pfd 44 22
fibrous dysplasia with pigmentary skin changes and precocious puberty 22
gonadotropin-independent female-limited sexual precocity 50
albright's syndrome with precocious puberty 22
albright-mccune-sternberg syndrome 22
fibrous dysplasia, polyostotic 22
properdin deficiency, x-linked 63
fibrous dysplasia polyostotic 46
albright-sternberg syndrome 22
albright's disease of bone 22
albright's syndrome 22


External Ids:

Disease Ontology9 DOID:1858
OMIM48 174800
MeSH36 D005357
MESH via Orphanet37 D005359, D005357
ICD10 via Orphanet27 Q78.1
SNOMED-CT via Orphanet60 36517007, 10623005
UMLS via Orphanet64 C0242292, C0016063, C0016065
ICD1026 M85.0, Q78.1

Related Diseases for Mccune Albright Syndrome

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18GeneCards, 19GeneDecks
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Diseases related to Mccune Albright Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous dysplasia31.8FGF23, GH1, GNAS
2acromegaly31.5PRL, GH1
3precocious puberty31.4GH1, PRL, GNRH1, GNAS
4hyperthyroidism31.2GNAS, PRL, GH1, FGF23
5gigantism31.1GNAS, PRL, GH1
6adenoma31.0GNAS, GNRH1, PRL, PRKAR1A, GH1
7pituitary adenoma31.0GNAS, GNRH1, PRL, PRKAR1A, GH1
8ovarian cyst30.9GNAS, GNRH1
9carney complex30.9PRKAR1A, GNAS
10hypophosphatemia30.8FGF23, PTHLH
11hyperparathyroidism30.7PTHLH, PRKAR1A, FGF23
12hypogonadotropism30.7GNRH1, PRL
13hypogonadism30.6GH1, PRL, GNRH1
14hyperprolactinemia30.6GNAS, GNRH1, PTHLH, PRL, GH1
15cushing's syndrome30.6PRL, PRKAR1A
16primary hyperparathyroidism30.6PTHLH, PRKAR1A, FGF23
17acth-independent macronodular adrenal hyperplasia30.6GNAS
18ollier disease30.5PTHLH
19empty sella syndrome30.5PRL, GH1
20infertility30.4FGF23, PRL, GNRH1
21pseudohypoparathyroidism30.4ADCY2, PTHLH, GNAS
22hypercalcemia30.3PTHLH, PRKAR1A, FGF23
23osteomalacia30.3GNAS, PTHLH, FGF23
24osteoporosis30.3PTHLH, PRKAR1A, GH1, FGF23
25pituitary tumors30.2GNAS, GNRH1, PRL, PRKAR1A, GH1
26breast cancer30.2GNRH1, PTHLH, PRL, PRKAR1A, GH1
27prolactinoma30.1GNAS, GNRH1, PTHLH, PRL, PRKAR1A, GH1
28pituitary apoplexy30.1GNRH1, PRL
29amenorrhea30.1GNRH1, PRL
30osteofibrous dysplasia11.1
31osteitis fibrosa10.7
32thyroiditis10.7
33forbes albright syndrome10.6
34rickets10.5
35osteosarcoma10.5
36testicular microlithiasis10.5
37somatostatin analog10.5
38peripheral precocious puberty10.5
39cervicitis10.5
40monostotic fibrous dysplasia10.4
41chondrosarcoma10.4
42neuropathy10.4
43mazabraud syndrome10.4
44hepatitis10.4
45pseudoarthrosis10.3
46neurofibromatosis10.3
47ductal carcinoma in situ10.3
48growth hormone secreting pituitary adenoma10.3
49paget's disease of bone10.3
50arteriovenous malformation10.3

Graphical network of the top 20 diseases related to Mccune Albright Syndrome:



Diseases related to mccune albright syndrome

Symptoms for Mccune Albright Syndrome

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48OMIM, 50Orphanet
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Symptoms by clinical synopsis from OMIM:

174800

Clinical features from OMIM:

174800

Symptoms:

50 (show all 35)
  • bone pain
  • macropenis/megapenis/large penis
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • cortico-adrenal hyperplasia/hypersecretion
  • hyperparathyroidy
  • breast neoplasm/tumor/carcinoma/cancer
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • testicular/seminal neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • thyroid neoplasm/tumor/carcinoma/cancer
  • palate anomalies
  • cushingoid morphotype
  • dental malocclusion
  • enamel anomaly
  • sarcoma
  • cafe-au-lait spot
  • macroorchidism/macrotestes
  • multiple caries
  • anomalies of teeth and dentition
  • prognathism/prognathia
  • dysostosis/chondrodysplasia/osteodysplasia/osteochondrosis/skeletal dysplasia
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • precocious puberty
  • kyphosis
  • optic nerve anomaly/optic atrophy/anomaly of the papilla
  • hypophosphatemia
  • anomalies of eyes and vision
  • abnormal hepatic enzymes/transaminases
  • tall stature/gigantism/growth acceleration
  • face/facial anomalies
  • hyperthyroidy
  • goiter
  • abnormal/polycystic ovaries
  • anomalies of ear and hearing
  • mutiple fractures/bone fragility
  • macrocephaly/macrocrania/megalocephaly/megacephaly

Drugs & Therapeutics for Mccune Albright Syndrome

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Mccune Albright Syndrome

Drug clinical trials:

Search ClinicalTrials for Mccune Albright Syndrome

Search NIH Clinical Center for Mccune Albright Syndrome

Search CenterWatch for Mccune Albright Syndrome

Genetic Tests for Mccune Albright Syndrome

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21GeneTests, 23GTR
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Genetic tests related to Mccune Albright Syndrome:

id Genetic test Affiliating Genes
1 Mccune-Albright Syndrome21 23 GNAS

Anatomical Context for Mccune Albright Syndrome

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34MalaCards
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MalaCards organs/tissues related to Mccune Albright Syndrome:

34
Bone, Skin, Pituitary, Thyroid, Ovary, Breast, Eye, Testes, Myeloid

Animal Models for Mccune Albright Syndrome or affiliated genes

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38MGI
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Publications for Mccune Albright Syndrome

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53PubMed
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Articles related to Mccune Albright Syndrome:

(show top 50)    (show all 319)
idTitleAuthorsYear
1
Hepatobiliary and Pancreatic Neoplasms in Patients With McCune-Albright Syndrome. (24170100)
2014
2
Transsphenoidal approach for pituitary adenomas in patients with McCune-Albright syndrome. (22797802)
2013
3
Intragenic suppression of a constitutively active allele of GsI+ associated with McCune-Albright syndrome. (23288949)
2013
4
Oral manifestations of McCune-Albright syndrome. (23776876)
2013
5
Fulvestrant treatment of precocious puberty in girls with McCune-Albright syndrome. (22999294)
2012
6
Hansen's disease with McCune-Albright syndrome. (23326081)
2012
7
Gastrointestinal polyps in McCune Albright syndrome. (21357941)
2011
8
Primary bimorphic adrenocortical disease: cause of hypercortisolism in McCune-Albright syndrome. (21836496)
2011
9
Upper lip bite test in a patient with McCune Albright syndrome with acromegaly. (20036127)
2010
10
McCune-Albright Syndrome: intensely hypermetabolic polyostotic fibrous dysplasia on F-18 FDG-PET. (19851179)
2009
11
Oral rehabilitation with endosseous implants in a patient with fibrous dysplasia (McCune-Albright syndrome): a case report. (19022142)
2008
12
Combined treatment with ketoconazole and cyproterone acetate in a boy with McCune-Albright syndrome and peripheral precocious puberty. (18997496)
2008
13
McCune-Albright syndrome: 70 years of fascination and discovery. (17937058)
2007
14
The spectrum of McCune Albright syndrome. (17982388)
2007
15
McCune-Albright syndrome associated with acromegaly and bipolar affective disorder. (18054713)
2007
16
Clinical approach to clarifying the mechanism of abnormal bone metabolism in McCune-Albright syndrome. (16369891)
2006
17
McCune-Albright syndrome and acromegaly: effects of hypothalamopituitary radiotherapy and/or pegvisomant in somatostatin analog-resistant patients. (16984995)
2006
18
Unexpected mosaicism of R201H-GNAS1 mutant-bearing cells in the testes underlie macro-orchidism without sexual precocity in McCune-Albright syndrome. (17101633)
2006
19
Clinical presentation of McCune-Albright syndrome in males. (16789625)
2006
20
McCune-Albright syndrome: growth hormone and prolactin hypersecretion. (16789626)
2006
21
Lack of efficacy of fadrozole in treating precocious puberty in girls with the McCune-Albright syndrome. (14671160)
2003
22
McCune-Albright syndrome with thyrotoxicosis. (11564936)
2001
23
Infantile McCune-Albright syndrome. (11841638)
2001
24
Neurofibromatosis type 1 and McCune-Albright syndrome occurring in the same patient. (11122036)
2000
25
McCune-Albright syndrome associated with non-autoimmune type of hyperthyroidism with development of thyrotoxic crisis. (11150888)
2000
26
Meningioma associated with McCune-Albright syndrome. (10653317)
1999
27
Activating mutation of GS alpha in McCune-Albright syndrome causes skin pigmentation by tyrosinase gene activation on affected melanocytes. (10844413)
1999
28
Tamoxifen treatment of progressive precocious puberty in a patient with McCune-Albright syndrome. (10703542)
1999
29
Ketoconazole treatment of gonadotropin independent precocious puberty in girls with McCune-Albright syndrome: a preliminary report. (10392352)
1999
30
Chondrosarcoma in a patient with McCune-Albright syndrome. Report of a case. (10327499)
1999
31
Secondary central precocious puberty in a girl with McCune-Albright syndrome responds to treatment with GnRH analogue. (9642633)
1998
32
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation. (9403710)
1997
33
McCune-Albright syndrome (polyostotic fibrous dysplasia) with intracranial frontoethmoid mucocele. (9141412)
1997
34
Clinical implications of genetic defects in G proteins. The molecular basis of McCune-Albright syndrome and Albright hereditary osteodystrophy. (8699958)
1996
35
Growth hormone-prolactin-thyrotropin-secreting pituitary adenoma in atypical McCune-Albright syndrome with functionally normal Gs alpha protein. (7962285)
1994
36
Residents' corner. Answer to case of the month #12. McCune-Albright syndrome (polyostotic fibrous dysplasia). (1562893)
1992
37
Pathologic fracture of the femoral neck in a patient with McCune-Albright syndrome. (1608869)
1992
38
In vitro production of estradiol by ovarian granulosa cells in a case of McCune-Albright syndrome. (1865081)
1991
39
Thyroid abnormalities in the McCune-Albright syndrome: ultrasonography and hormonal studies. (2229316)
1990
40
Hypersecretion of growth hormone and prolactin in McCune-Albright syndrome. (2498385)
1989
41
McCune-Albright syndrome with gigantism and hyperprolactinemia. (3680873)
1987
42
The McCune-Albright syndrome. (3545811)
1987
43
Value of bone scan in the McCune-Albright syndrome. Report of a case. (3812022)
1986
44
Autonomous ovarian hyperfunction followed by gonadotrophin-dependent puberty in McCune-Albright syndrome. (3085997)
1986
45
Testolactone treatment of precocious puberty in McCune-Albright syndrome. (3925675)
1985
46
McCune-Albright syndrome (fibrous dysplasia) associated with an orbital tumor. (6712072)
1984
47
Cyclical ovarian function resistant to treatment with an analogue of luteinizing hormone releasing hormone in McCune-Albright syndrome. (6434946)
1984
48
Hyperprolactinaemia in a patient with the McCune-Albright Syndrome. (571285)
1979
49
McCune-Albright syndrome with endocrinological investigations. Report of a case. (5410568)
1970
50
Sexual precocity in females; report of two cases, with arrest of precocity in the McCune-Albright syndrome after removal of a cystic ovary. (14891326)
1951

Variations for Mccune Albright Syndrome

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Mccune Albright Syndrome:

65
id Symbol AA change Variation ID SNP ID
1GNASp.Arg201HisVAR_003441
2GNASp.Arg201CysVAR_003442rs11554273
3GNASp.Arg201GlyVAR_017844

Clinvar genetic disease variations for Mccune Albright Syndrome:

1
id Gene Name Type Significance SNP ID Assembly Location
1CFPNM_002621.2(CFP): c.481C> T (p.Arg161Ter)single nucleotide variantPathogenicrs132630258GRCh37Chr X, 47486963: 47486963
2CFPNM_002621.2(CFP): c.893G> T (p.Gly298Val)single nucleotide variantPathogenicrs28935480GRCh37Chr X, 47486219: 47486219
3CFPNM_002621.2(CFP): c.617C> G (p.Ser206Ter)single nucleotide variantPathogenicrs132630260GRCh37Chr X, 47486689: 47486689
4GNASNM_001077488.2(GNAS): c.604C> T (p.Arg202Cys)single nucleotide variantPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420
5GNASNM_001077488.2(GNAS): c.605G> A (p.Arg202His)single nucleotide variantPathogenicrs121913495GRCh37Chr 20, 57484421: 57484421
6GNASNM_001077488.2(GNAS): c.604C> G (p.Arg202Gly)single nucleotide variantPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420

Expression for genes affiliated with Mccune Albright Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mccune Albright Syndrome

Search GEO for disease gene expression data for Mccune Albright Syndrome.

Pathways for genes affiliated with Mccune Albright Syndrome

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51PathCards, 56Reactome, 52PharmGKB, 31KEGG, 13EMD Millipore, 39NCBI BioSystems Database, 61Thomson Reuters, 54QIAGEN
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Pathways related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GH1, PRL
2
Show member pathways
9.6PRL, GH1
39.6ADCY2, GNAS
49.6GNAS, ADCY2
59.6ADCY2, GNAS
69.6ADCY2, GNAS
79.6ADCY2, GNAS
89.6GNAS, ADCY2
99.4GH1, PTHLH
10
Show member pathways
9.3PRKAR1A, GNAS
119.3GNAS, PRKAR1A
129.2PRL, GH1, FGF23
13
Show member pathways
9.2FGF23, GH1, PRL
14
Show member pathways
9.2FGF23, ADCY2, GNAS
159.1PRKAR1A, ADCY2
16
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
9.1GNAS, GNRH1, ADCY2
179.0ADCY2, PTHLH, GNAS
18
Show member pathways
9.0ADCY2, PTHLH, GNAS
19
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
8.9GNAS, PRKAR1A, GH1
20
Show member pathways
8.8GNAS, ADCY2, PRKAR1A
21
Show member pathways
8.8GNAS, ADCY2, PRKAR1A
22
Show member pathways
Development Beta adrenergic receptors regulation of ERK61
G protein signaling G Protein alpha s signaling cascades61
G protein signaling G Protein beta gamma signaling cascades61
8.8GNAS, ADCY2, PRKAR1A
238.8GNAS, ADCY2, PRKAR1A
24
Show member pathways
Signal transduction cAMP signaling61
8.8PRKAR1A, ADCY2, GNAS
25
Show member pathways
8.8PRKAR1A, ADCY2, GNAS
26
Show member pathways
8.8PRKAR1A, ADCY2, GNAS
27
Show member pathways
Calcium Regulation in the Cardiac Cell39
8.8PRKAR1A, ADCY2, GNAS
28
Show member pathways
Apoptosis and survival BAD phosphorylation61
Development Alpha 2 adrenergic receptor activation of ERK61
Chemotaxis CXCR4 signaling pathway61
8.8PRKAR1A, ADCY2, GNAS
29
Show member pathways
8.8FGF23, PRKAR1A, ADCY2
30
Show member pathways
8.7ADCY2, PRKAR1A, GH1
31
Show member pathways
8.7GNRH1, PRL, GH1, FGF23
328.7GNAS, PTHLH, PRKAR1A
33
Show member pathways
8.6FGF23, GH1, ADCY2, GNRH1
34
Show member pathways
8.6PRKAR1A, ADCY2, GNRH1
35
Show member pathways
8.6PRKAR1A, ADCY2, GNRH1
36
Show member pathways
8.4GNAS, ADCY2, PRKAR1A, FGF23
37
Show member pathways
8.3GNRH1, PRKAR1A, GH1, FGF23
38
Show member pathways
8.3FGF23, GH1, PRKAR1A, GNRH1
398.3ADCY2, PRL, PRKAR1A, FGF23
40
Show member pathways
7.9ADCY2, PRL, PRKAR1A, GH1, FGF23
41
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
42
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
43
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
44
Show member pathways
7.8FGF23, GH1, PRKAR1A, ADCY2, GNRH1
45
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
46
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
47
Show member pathways
7.8GNRH1, ADCY2, PRKAR1A, GH1, FGF23
48
Show member pathways
7.6GNAS, GNRH1, PTHLH, ADCY2, PRL, GH1
49
Show member pathways
6.4FGF23, GNAS, GNRH1, PTHLH, ADCY2, PRL

Compounds for genes affiliated with Mccune Albright Syndrome

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46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1quinagolide4610.0PRL, GH1
2ghrp469.8GH1, PRL
3estradiol benzoate469.7GNRH1, PRL
4leuprolide46 62 30 1212.7GNRH1, PRL
55-hydroxytryptophan469.7GH1, PRL
6adenosine 3,5-cyclic monophosphorothioate469.7PTHLH, GNRH1
7mhpg469.6GNRH1, PRL
8hexarelin46 3010.6PRL, GH1
9lanreotide46 3010.6PRL, GH1
10leuprolide acetate469.5GNRH1, PRL, GH1
11clomiphene citrate469.5PRL, GNRH1, GH1
12pyridostigmine46 1210.5GH1, PRL
13naltrexone46 30 52 1212.5GNRH1, PRL, GH1
14cabergoline46 30 1211.5GH1, PRL, GNRH1
15metoclopramide46 52 1211.5GH1, GNRH1, PRL
16bromocriptine46 30 1211.5GNRH1, GH1, PRL
17naloxone46 30 52 1212.5PRL, GNRH1, GH1
18dehydroepiandrosterone sulfate469.5PRL, GNRH1, GH1
19opiate469.5GH1, GNRH1, PRL
20androstenedione46 2510.4GH1, GNRH1, PRL
21estrone46 30 25 1212.4GH1, GNRH1, PRL
221,25 dihydroxy vitamin d3469.4FGF23, GH1, PTHLH
23sulpiride46 30 1211.3PRL, GH1
24hydrocortisone46 3 62 1212.3GH1, PRL, PTHLH
25progestin469.2GNRH1, PRL, PTHLH
26verapamil46 30 52 25 1213.2GNRH1, PTHLH, GH1
27nifedipine46 30 52 1212.2GH1, PTHLH, GNRH1
28acth469.1GH1, PRL, GNAS, GNRH1
29gnrh469.1GH1, PRL, GNRH1, GNAS
30dihydrotestosterone46 30 25 1211.9GH1, PTHLH, PRL, GNRH1
31thyroxine46 259.9GH1, PRL, PTHLH, GNRH1
32creatinine468.9FGF23, GH1, GNRH1, PTHLH
33tamoxifen46 52 30 1211.8GH1, PRL, PTHLH, GNRH1
34heparin46 30 25 1211.8GNRH1, FGF23, GH1, PTHLH
35estradiol46 25 1210.8GNRH1, PTHLH, PRL, GH1
36dopamine46 30 25 1211.7PRL, GNAS, GNRH1, ADCY2, GH1
37vitamin d468.6PRKAR1A, GH1, FGF23, PTHLH
38testosterone46 62 25 1211.6GH1, PRL, PTHLH, GNRH1
39ribonucleic acid468.6GNRH1, GNAS, GH1, PRL, PTHLH
40norepinephrine46 25 1210.6PTHLH, GNRH1, GNAS, PRL, GH1
41progesterone46 30 62 25 1212.5GH1, GNRH1, GNAS, PTHLH, PRL
42isoproterenol46 129.5ADCY2, PTHLH, GNRH1, GNAS, GH1
43cyclic amp46 259.4GNAS, PRKAR1A, ADCY2, PTHLH
44octreotide46 62 30 1211.2PTHLH, PRL, GNRH1, GNAS, GH1, FGF23
45forskolin46 52 1210.2GH1, PRKAR1A, ADCY2, PTHLH, GNAS
46glucose468.2PRL, GNAS, PTHLH, PRKAR1A, GH1
47dexamethasone46 52 30 1211.0PRKAR1A, GNRH1, PRL, PTHLH, GH1
48steroid467.7PRL, PRKAR1A, GH1, PTHLH, GNAS, GNRH1
49adenylate467.7GNRH1, ADCY2, PRKAR1A, GH1, GNAS, PTHLH
50arginine467.4GNAS, GNRH1, PRL, PRKAR1A, GH1, FGF23

GO Terms for genes affiliated with Mccune Albright Syndrome

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17Gene Ontology
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Cellular components related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5FGF23, GH1, PTHLH, GNRH1
2extracellular regionGO:0055767.4FGF23, GNAS, GNRH1, PTHLH, PRL, GH1

Biological processes related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1cAMP biosynthetic processGO:0061719.9ADCY2, GNAS
2positive regulation of JAK-STAT cascadeGO:0464279.9GH1, PRL
3JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.8GH1, PRL
4endochondral ossificationGO:0019589.6PTHLH, GNAS
5positive regulation of cAMP biosynthetic processGO:0308199.5PTHLH, GNAS
6activation of protein kinase A activityGO:0341999.3PRKAR1A, ADCY2
7regulation of insulin secretionGO:0507969.3PRKAR1A, GNAS
8adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.3GNAS, PTHLH, ADCY2
9regulation of gene expressionGO:0104689.2PTHLH, GNRH1
10cellular response to glucagon stimulusGO:0713779.1GNAS, ADCY2, PRKAR1A
11water transportGO:0068339.1GNAS, ADCY2, PRKAR1A
12energy reserve metabolic processGO:0061129.1GNAS, ADCY2, PRKAR1A
13fibroblast growth factor receptor signaling pathwayGO:0085439.0ADCY2, PRKAR1A, FGF23
14epidermal growth factor receptor signaling pathwayGO:0071738.9ADCY2, PRKAR1A, FGF23
15female pregnancyGO:0075658.8PRL, PTHLH, GNRH1, GNAS
16activation of phospholipase C activityGO:0072028.8PRKAR1A, ADCY2
17neurotrophin TRK receptor signaling pathwayGO:0480118.8ADCY2, PRKAR1A, FGF23

Molecular functions related to Mccune Albright Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein beta/gamma-subunit complex bindingGO:0316839.6ADCY2, GNAS
2prolactin receptor bindingGO:0051489.5PRL, GH1
3adenylate cyclase activityGO:0040169.3ADCY2, GNAS
4hormone activityGO:0051798.5GH1, PRL, PTHLH, GNRH1

Products for genes affiliated with Mccune Albright Syndrome

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Sources for Mccune Albright Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet