MCID: MSL001
MIFTS: 66

Measles malady

Infectious diseases category

Summaries for Measles

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Measles is an infectious disease caused by a virus. it spreads easily from person to person. the main symptom of measles is an itchy skin rash. the rash often starts on the head and moves down the body. other symptoms include fever cough runny nose conjunctivitis (pink eye) feeling achy and run down tiny white spots inside the mouth sometimes measles can lead to serious problems. there is no treatment for measles, but the measles-mumps-rubella (mmr) vaccine can prevent it. "german measles", also known as rubella, is a completely different illness. centers for disease control and prevention

MalaCards: Measles, also known as morbilli, is related to rubella and mumps, and has symptoms including maculopapular, conjunctivitis and coryza. An important gene associated with Measles is CD46 (CD46 molecule, complement regulatory protein), and among its related pathways are Influenza A and Immune System. The compounds tyrosine and lipid have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and brain, and related mouse phenotypes are immune system and cellular.

Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in measles virus, which is transmitted by contact with oronasal secretions, or semen of an infected person. the infection has symptom fever, has symptom cough, has symptom coryza, has symptom conjunctivitis, and has symptom maculopapular, erythematous rash.

CDC:3 Measles is a highly contagious respiratory disease caused by a virus. The disease of measles and the virus that causes it share the same name. The disease is also called rubeola.

Wikipedia:63 Measles, also known as morbilli, English measles, or rubeola (and not to be confused with rubella or... more...

Aliases & Classifications for Measles

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Measles

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17GeneCards, 18GeneDecks
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Diseases related to Measles via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 197)
idRelated DiseaseScoreTop Affiliating Genes
1rubella31.5RNPC3, CD40LG
2mumps31.5IRF1
3subacute sclerosing panencephalitis31.2IRF1, CD46, MX1, SLAMF1
4meningitis30.6CD46, CCL4
5hepatitis30.6TLR3, IFNB1, IRF1, CD40LG, MX1
6influenza30.5CCL4, TLR3, IFNB1, IRF1, LBR, HLA-DMA
7encephalitis30.5CCL4, TLR3, CD46, IL12B, MX1
8hepatitis b30.4TLR3, IFNAR2, IRF1, RNPC3, MX1
9multiple sclerosis30.4CCL4, TLR3, IFNAR2, IFNB1, IRF1, LBR
10encephalomyelitis30.4IFNB1, CCL4
11pneumonia30.3TLR3, IRF1, RBP4
12leukemia30.2LBR, IRF1, IFNB1, CCL4, RBP4, CD46
13neuritis30.2CCL4
14acute leukemia30.1IRF1, CD46, PTPN6
15ovarian cancer30.1TLR3, IFNB1, IRF1, LBR, RBP4, CD46
16asthma30.1TLR3, IFNB1, IRF1, SCT, LBR, IL12B
17arthritis30.0CCL4, TLR3, IRF1, MX1
18malaria30.0IL12B, RBP4
19hepatitis c29.9TLR3, IFNAR2, IFNB1, IRF1, RBP4, CD40LG
20tuberculosis29.9CCL4, IFNB1, GNLY, IRF1, LBR, IL12B
21pancreatitis29.9SCT
22breast cancer29.7LGALS4, CCL4, IFNAR2, IFNB1, IRF1, RBP4
23melanoma29.7CCL4, TLR3, IFNAR2, IFNB1, IRF1, LBR
24rheumatoid arthritis29.7CCL4, TLR3, IFNB1, LBR, HLA-DMA, CD40LG
25adenocarcinoma29.7IFNAR2, IFNB1, IRF1, SCT, CD46, MSN
26herpes simplex29.7TLR3, IFNB1, IRF1, LBR, IL12B, MX1
27hepatocellular carcinoma29.7TLR3, IFNAR2, IFNB1, IRF1, SCT, RBP4
28myeloma29.7CCL4, IFNAR2, IRF1, CD40LG
29newcastle disease29.7LBR, IRF1, IFNB1
30hemophagocytic lymphohistiocytosis29.7MX1, IFNB1
31biliary atresia29.7MX1
32toxic shock syndrome29.7LBR, CCL4
33pancreatic cancer29.7SCT
34diphtheria10.5
35scarlet fever10.4
36tetanus10.4
37otosclerosis10.3
38aseptic meningitis10.3
39pertussis10.3
40exanthem10.3
41chickenpox10.3
42hepatitis a10.3
43poliomyelitis10.3
44myelitis10.2
45neuronitis10.2
46acute disseminated encephalomyelitis10.2
47central nervous system disease10.2
48nervous system disease10.2
49dawson disease10.2
50bronchopneumonia10.2

Graphical network of the top 20 diseases related to Measles:



Diseases related to measles

Clinical Features for Measles

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Sources:
8Disease Ontology
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Symptoms:

8
  • maculopapular
  • conjunctivitis
  • coryza
  • cough
  • fever

Drugs & Therapeutics for Measles

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Measles

Drug clinical trials:

Search ClinicalTrials for Measles

Search NIH Clinical Center for Measles

Search CenterWatch for Measles

Genetic Tests for Measles

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Anatomical Context for Measles

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Measles:

32
Skin, Brain, Eye, T cells, Testes, B cells, Lung, Bone, Endothelial, Monocytes, Liver, Thyroid, Bone marrow, Myeloid, Tonsil, Prostate, Breast, Spinal cord

FMA organs/tissues related to Measles:

14
Skin

Animal Models for Measles or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Measles:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.3PTPN6, TLR3, IFNAR2, IFNB1, IRF1, LBR
2MP:000538411.2IRF1, LBR, HLA-DMA, RBP4, CD40LG, IL12B
3MP:000539711.1IFNAR2, IFNB1, IRF1, LBR, HLA-DMA, CD40LG
4MP:000537611.0TLR3, IFNAR2, IFNB1, IRF1, SCT, LBR

Publications for Measles

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Sources:
50PubMed
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Articles related to Measles:

(show top 50)    (show all 1186)
idTitleAuthorsYear
1
Lack of herd immunity against measles in individuals aged <35 years could explain re-emergence of measles in Catalonia (Spain). (24211476)
2014
2
Progress towards measles elimination in the Western Pacific Region, 2009a892012. (23757799)
2013
3
Characteristics of viruses derived from nude mice with persistent measles virus infection. (23345518)
2013
4
Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein. (23115278)
2013
5
Contribution of dendritic cells to measles virus induced immunosuppression. (23280948)
2013
6
Seropositivity rates for measles, mumps, and rubella IgG and costs associated with testing and revaccination. (23345583)
2013
7
Simple method to differentiate measles vaccine from wild-type strains using loop-mediated isothermal amplification (LAMP). (23336333)
2013
8
Human mesenchymal stromal cells deliver systemic oncolytic measles virus to treat acute lymphoblastic leukemia in the presence of humoral immunity. (24345754)
2013
9
Measles (rubeola): an ongoing series on infectious diseases of importance to the deployed special forces. (23526326)
2013
10
Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4. (23202587)
2013
11
Primary resistance phenomena to oncolytic measles vaccine viruses. (23612727)
2013
12
Expression and purification of chimeric peptide comprising EGFR B-cell epitope and measles virus fusion protein T-cell epitope in Escherichia coli. (23220378)
2013
13
Seroprevalence of measles-, mumps- and rubella-specific IgG antibodies in German children and adolescents and predictors for seronegativity. (22880124)
2012
14
Immunogenicity, immunologic memory, and safety following measles revaccination in HIV-infected children receiving highly active antiretroviral therapy. (22693229)
2012
15
Nectin 4 is the epithelial cell receptor for measles virus. (22721863)
2012
16
Antibody persistence for 3 years following two doses of tetravalent measles-mumps-rubella-varicella vaccine in healthy children. (21935584)
2012
17
Treatment of medulloblastoma using an oncolytic measles virus encoding the thyroidal sodium iodide symporter shows enhanced efficacy with radioiodine. (23134812)
2012
18
Progress towards measles and rubella elimination in Tuscany, Italy: the role of population seroepidemiological profile. (20880991)
2012
19
Membrane fusion triggering: three modules with different structure and function in the upper half of the measles virus attachment protein stalk. (23007387)
2012
20
Effectiveness and timing of vaccination during school measles outbreak. (22931850)
2012
21
Expanding poliomyelitis and measles surveillance networks to establish surveillance for acute meningitis and encephalitis syndromes--Bangladesh, China, and India, 2006-2008. (23235298)
2012
22
Measles laboratory-based surveillance in Zimbabwe during 2004-2009. (24432262)
2012
23
Immature CD4+CD8+ thymocytes are preferentially infected by measles virus in human thymic organ cultures. (23029357)
2012
24
Anaphylactic reactions to measles-mumps-rubella vaccine in three children with allergies to hen's egg and cow's milk. (21244488)
2011
25
Adherens junction protein nectin-4 is the epithelial receptor for measles virus. (22048310)
2011
26
Immunogenicity and safety of an inactivated hepatitis A vaccine when coadministered with measles-mumps-rubella and varicella vaccines in children less than 2 years of age. (21617573)
2011
27
Multiple sclerosis incidence in the era of measles-mumps-rubella mass vaccinations. (19154535)
2009
28
Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results. (18325643)
2008
29
A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-independent mechanism. (17715217)
2007
30
Assessing participation bias in a population-based study of measles-mumps-rubella vaccine immunity in children and adolescents aged 12-18. (17564596)
2007
31
Lymphoma chemovirotherapy: CD20-targeted and convertase-armed measles virus can synergize with fludarabine. (18006839)
2007
32
Measles virus vaccine attenuation: suboptimal infection of lymphatic tissue and tropism alteration. (17624839)
2007
33
Effect of the alterations in the fusion protein of measles virus isolated from brains of patients with subacute sclerosing panencephalitis on syncytium formation. (17825451)
2007
34
Taking a closer look: an examination of measles, mumps, and rubella immunization uptake in Saskatoon. (17985687)
2007
35
Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus. (15827165)
2005
36
Progress toward elimination of measles and prevention of congenital rubella infection--European region, 1990-2004. (15729220)
2005
37
Subacute sclerosing panencephalitis: more cases of this fatal disease are prevented by measles immunization than was previously recognized. (16235165)
2005
38
Rubella and congenital rubella (German measles). (16022642)
2005
39
Accelerated rubella control and congenital rubella syndrome prevention strengthen measles eradication: the Costa Rican experience. (12721908)
2003
40
Immunodominant domains of the Measles virus hemagglutinin protein eliciting a neutralizing human B cell response. (14579178)
2003
41
Combined vaccination by measles and hepatitis B vaccines: a new cause of Gianotti-Crosti syndrome. (11834856)
2002
42
Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification. (12270725)
2002
43
Clinical significance of the serum surfactant protein D and KL-6 levels in patients with measles complicated by interstitial pneumonia. (11475580)
2001
44
Proposed vaccine information materials for hepatitis B, Haemophilus influenzae type b (Hib), Varicella (chickenpox), and measles, mumps, rubella (MMR) vaccines--CDC. Notice with comment period. (10182707)
1998
45
Measles, mumps, and rubella--vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: recommendations of the Advisory Committee on Immunization Practices (ACIP). (9639369)
1998
46
Otosclerosis: a measles virus associated inflammatory disease. (7610826)
1995
47
Synthesis of antibodies against measles virus and myelin by in vitro stimulated B-cells derived from patients with subacute sclerosing panencephalitis. (7507883)
1993
48
Antibodies to myelin basic protein and measles virus in multiple sclerosis: precursor frequency analysis of the antibody producing B cells. (1725965)
1991
49
Interstitial emphysema in measles. (14772474)
1950
50
Scarlet fever, diphtheria, measles, and whooping cough in Glasgow from 1916 to 1945. (18120885)
1949

Genetic Variations for Measles

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Expression for genes affiliated with Measles

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Measles

Search GEO for disease gene expression data for Measles.

Pathways for genes affiliated with Measles

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Sources:
29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Measles according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2MSN, TLR3, IFNAR2, IFNB1, HLA-DMA, CD46
2
Hide members
11.1TLR3, IFNAR2, IFNB1, IRF1, HLA-DMA, CD46
3
Hide members
10.9IFNAR2, IFNB1, IRF1, MX1, PTPN6
4
Immune response IFN alpha/beta signaling pathway
Hide members
10.9IFNAR2, IFNB1, IRF1, MX1, PTPN6
5
Hide members
10.9CCL4, TLR3, IFNAR2, IFNB1, IL12B
6
Hide members
10.8IL12B, CD40LG, HLA-DMA, IFNAR2
710.8IRF1, IFNB1, IFNAR2, TLR3
810.8IFNAR2, IFNB1, IL12B, PTPN6
9
Hide members
10.8HLA-DMA, CD40LG, IL12B, PTPN6

Compounds for genes affiliated with Measles

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Measles according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1tyrosine4412.1SCT, IRF1, IFNB1, IFNAR2, TLR3, CCL4
2lipid4411.9IFNAR2, IFNB1, GNLY, IRF1, SCT, LBR
3calcium44 49 11 2414.9LBR, SCT, IRF1, IFNB1, CCL4, RBP4
4serine4411.8CCL4, TLR3, GNLY, IRF1, SCT, RBP4
5retinoic acid44 2412.8CCL4, TLR3, IFNAR2, IFNB1, IRF1, SCT
6alanine4411.7RBP4, IFNB1, IFNAR2, CCL4, CD46, CD40LG
7phosphatidylinositol4411.7CCL4, TLR3, IFNAR2, IRF1, SCT, CD46
8oligonucleotide4411.6TLR3, IFNB1, GNLY, PTPN6, MSN, RNPC3
9zinc44 2412.6IFNB1, IRF1, SCT, LBR, RBP4, RNPC3
10rantes4411.6IL12B, CCL4, IFNB1, IRF1, SCT, LBR
11cysteine4411.5CCL4, IFNB1, SCT, LBR, RBP4, CD40LG
12progesterone44 59 28 11 2415.5CCL4, IFNB1, GNLY, LBR, RBP4, CD46
13arginine4411.4GNLY, IRF1, SCT, LBR, CD40LG, RNPC3
14nitric oxide44 11 2413.4CCL4, TLR3, IRF1, LBR, CD46, IL12B
15dexamethasone44 49 28 1114.4TLR3, IFNB1, LBR, RBP4, CD46, CD40LG
16cyclosporin a44 28 5913.3CCL4, SCT, LBR, CD46, CD40LG, RNPC3
172,5-oligoadenylate4411.3TLR3, IFNAR2, IFNB1, IRF1, MX1
18poly(i-c)4411.3TLR3, IFNB1, IRF1, IL12B, MX1
19thymidine44 2412.3IFNB1, IRF1, SCT, LBR, PTPN6, LGALS4
20ifn-alpha4411.3TLR3, IFNAR2, IFNB1, IRF1, MX1
21leucine4411.3LBR, HLA-DMA, RBP4, RNPC3, MX1, LGALS4
22adenylate4411.3IFNB1, IRF1, SCT, RBP4, CD40LG, RNPC3
23chloramphenicol44 2 1113.3IFNB1, IRF1, LBR, MX1, LGALS4
24cholesterol44 28 11 2414.2CCL4, IFNB1, GNLY, LBR, RBP4, LGALS4
25imiquimod44 28 59 1114.2MX1, IL12B, IFNB1, TLR3
26cycloheximide4411.2IFNB1, IRF1, MX1, MSN
27polyinosinic-polycytidylic acid4411.2TLR3, IFNB1, IRF1, IL12B
28steroid4411.2CCL4, IFNB1, GNLY, LBR, RBP4, LGALS4
29polysaccharide4411.2CCL4, IFNB1, CD46, CD40LG, LGALS4
30peptidoglycan44 2812.2CCL4, TLR3, IFNB1, IL12B
31ribavirin44 49 1113.2IFNB1, LBR, CD40LG, MX1
32neopterin4411.2IFNB1, LBR, CD40LG, MX1
33poly c4411.1RNPC3, IFNB1, TLR3
34thyroxine44 2412.1IFNB1, SCT, RBP4, CD40LG
35genistein44 28 59 2 11 2416.1LGALS4, PTPN6, CD40LG, LBR, IFNB1
36inosine monophosphate4411.0TLR3, IFNB1, IRF1
37lipoteichoic acid4411.0TLR3, IFNB1, IL12B
38ionomycin4411.0CCL4, GNLY, LBR, CD40LG
39endotoxin4411.0TLR3
40rebif4411.0MX1, IFNB1
41avonex4410.9MX1, IFNB1
42estrogen4410.9MSN
43ursodeoxycholic acid44 11 2412.9SCT, LBR, CD40LG
44estradiol44 11 2412.9GNLY, IFNB1
45il 104410.8IL12B, IFNB1, CCL4
46Alpha-D-Mannose1110.8IL12B, CD46, IFNB1
47ccl444 2811.7IL12B, IFNB1, CCL4
48betaseron4410.6IFNB1, MX1
49tobramycin4410.5RBP4, RNPC3
50ivig4410.4CD40LG, IFNB1, CCL4

GO Terms for genes affiliated with Measles

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16Gene Ontology
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Cellular components related to Measles according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.1IL12B, CD40LG, RBP4, GNLY, IFNB1, IFNAR2

Biological processes related to Measles according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1type I interferon-mediated signaling pathwayGO:06033711.1PTPN6, MX1, IRF1, IFNB1, IFNAR2
2defense response to virusGO:05160711.1TLR3, IFNB1, IRF1, IL12B, MX1
3cytokine-mediated signaling pathwayGO:01922111.1PTPN6, MX1, IRF1, IFNB1, IFNAR2
4positive regulation of interleukin-12 productionGO:03273510.9TLR3, CD40LG, IL12B
5response to virusGO:00961510.9CCL4, IFNAR2, IFNB1, MX1
6regulation of type I interferon-mediated signaling pathwayGO:06033810.8PTPN6, IFNB1, IFNAR2
7positive regulation of interferon-gamma biosynthetic processGO:04507810.6TLR3, IL12B
8natural killer cell activationGO:03010110.6IL12B, IFNB1
9B cell proliferationGO:04210010.5IFNB1, CD40LG
10defense response to bacteriumGO:04274210.4GNLY, IFNB1, TLR3

Molecular functions related to Measles according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.5TLR3, IFNAR2, IRF1, LBR, RBP4, MYBPH
2cytokine activityGO:00512510.5IL12B, CD40LG, IFNB1, CCL4

Products for genes affiliated with Measles

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Measles

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet