MCID: MSL001
MIFTS: 62

Measles malady

Infectious category

Summaries for Measles

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 33MalaCards
See all sources

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MedlinePlus:34 Measles is an infectious disease caused by a virus. it spreads easily from person to person. the main symptom of measles is an itchy skin rash. the rash often starts on the head and moves down the body. other symptoms include fever cough runny nose conjunctivitis (pink eye) feeling achy and run down tiny white spots inside the mouth sometimes measles can lead to serious problems. there is no treatment for measles, but the measles-mumps-rubella (mmr) vaccine can prevent it. "german measles", also known as rubella, is a completely different illness. centers for disease control and prevention

MalaCards: Measles, also known as morbilli, is related to rubella and mumps, and has symptoms including fever, cough and coryza. An important gene associated with Measles is CD46 (CD46 molecule, complement regulatory protein), and among its related pathways are Influenza A and Immune System. The compounds tyrosine and lipid have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and bone marrow, and related mouse phenotypes are immune system and cellular.

Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in measles virus, which is transmitted by contact with oronasal secretions, or semen of an infected person. the infection has symptom fever, has symptom cough, has symptom coryza, has symptom conjunctivitis, and has symptom maculopapular, erythematous rash.

CDC:3 Measles is a highly contagious respiratory disease caused by a virus. The disease of measles and the virus that causes it share the same name. The disease is also called rubeola.

Aliases & Classifications for Measles

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Related Diseases for Measles

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Measles via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1rubella31.6RNPC3, CD40LG
2mumps31.5IRF1
3subacute sclerosing panencephalitis31.2IRF1, CD46, MX1, SLAMF1
4hepatitis c30.6TLR3, IFNAR2, IFNB1, IRF1, RBP4, CD40LG
5acute leukemia30.2IRF1, CD46, PTPN6
6asthma30.1TLR3, IFNB1, IRF1, SCT, LBR, IL12B
7arthritis30.1CCL4, TLR3, IRF1, MX1
8tuberculosis30.0CCL4, IFNB1, GNLY, IRF1, LBR, IL12B
9hepatitis b30.0TLR3, IFNAR2, IRF1, RNPC3, MX1
10adenocarcinoma29.7IFNAR2, IFNB1, IRF1, SCT, CD46, MSN
11newcastle disease29.7LBR, IRF1, IFNB1
12hemophagocytic lymphohistiocytosis29.7MX1, IFNB1
13biliary atresia29.7MX1
14toxic shock syndrome29.7LBR, CCL4
15diphtheria10.5
16congenital rubella10.5
17scarlet fever10.5
18tetanus10.5
19otosclerosis10.4
20aseptic meningitis10.4
21chickenpox10.3
22hepatitis a10.3
23myelitis10.2
24acute disseminated encephalomyelitis10.2
25dawson disease10.2
26bronchopneumonia10.2
27congenital mumps10.2
28transverse myelitis10.2
29yellow fever10.1
30brain disease10.1
31stomatitis10.1
32xerophthalmia10.1
33protein-losing enteropathy10.1
34hepatitis d10.1
35infectious mononucleosis10.1
36n syndrome10.1
37rocky mountain spotted fever10.1
38spotted fever10.1
39febrile seizures10.1
40erythema infectiosum10.0
41toxic epidermal necrolysis10.0
42viral infectious disease10.0CD46, CD40LG, RNPC3, IL12B, MX1, SLAMF1
43ipex syndrome10.0LBR, IRF1, GNLY, IFNB1, CCL4, CD46
44systemic lupus erythematosus10.0CCL4, IFNB1, LBR, HLA-DMA, RBP4, CD46
45multiple sclerosis10.0CCL4, TLR3, IFNAR2, IFNB1, IRF1, LBR
46burkitt's lymphoma10.0CCL4, IRF1, LBR, RBP4, CD46, CD40LG
47influenza10.0CCL4, TLR3, IFNB1, IRF1, LBR, HLA-DMA
48leukemia10.0LBR, IRF1, IFNB1, CCL4, RBP4, CD46
49breast cancer10.0LGALS4, CCL4, IFNAR2, IFNB1, IRF1, RBP4
50melanoma10.0CCL4, TLR3, IFNAR2, IFNB1, IRF1, LBR

Graphical network of the top 20 diseases related to Measles:



Diseases related to measles

Clinical Features for Measles

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 5)
  • fever
  • cough
  • coryza
  • conjunctivitis
  • maculopapular

Drugs & Therapeutics for Measles

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Measles

Drug clinical trials:

Search ClinicalTrials for Measles

Search NIH Clinical Center for Measles

Search CenterWatch for Measles

Genetic Tests for Measles

Anatomical Context for Measles

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Measles:

33
Skin, Bone marrow, Brain, Spinal cord, Liver, Lung, Thyroid, Breast, Prostate, Tonsil, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

FMA organs/tissues related to Measles:

14
Skin

Animal Models for Measles or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Measles

Sources:
51PubMed
See all sources

Articles related to Measles:

(show top 50)    (show all 1187)
idTitleAuthorsYear
1
Comparison of automated chemiluminescence immunoassays with capture enzyme immunoassays for the detection of measles and mumps IgM antibodies in serum. (24183918)
2014
2
Specific elimination of CD133+ tumor cells with targeted oncolytic measles virus. (23293278)
2013
3
Measles control strategies in India: position paper of Indian Academy of Pediatrics. (23942398)
2013
4
Measles in the UK: a test of public health competency in a crisis. (23635544)
2013
5
Previous vaccination modifies both the clinical disease and immunological features in children with measles. (23748389)
2013
6
Adult patients hospitalized for measles in France, in the 21st century. (24050842)
2013
7
Measles vaccination coverage estimates from surveys, clinic records, and immune markers in oral fluid and blood: a population-based cross-sectional study. (24359402)
2013
8
Pandora box opened--measles unleashed in Pakistan! (24392576)
2013
9
Measles vaccination using a microneedle patch. (23044406)
2013
10
Rinderpest eradication: lessons for measles eradication? (22709518)
2012
11
Measles-containing vaccines and febrile seizures in children age 4 to 6 years. (22473362)
2012
12
Seroprevalence of measles, mumps, rubella, varicella-zoster and hepatitis A-C in Emirati medical students. (23217121)
2012
13
Global reduction in measles mortality. (23063273)
2012
14
The optimal age of measles immunisation in low-income countries: a secondary analysis of the assumptions underlying the current policy. (22815465)
2012
15
Evaluation of an expanded case definition for vaccine-modified measles in a school outbreak in South Korea in 2010. (22996208)
2012
16
Nosocomial transmission of measles: an updated review. (22521843)
2012
17
Measles virus C protein interferes with Beta interferon transcription in the nucleus. (22072748)
2012
18
Similarity of parents and physicians in the decision to vaccinate children against measles, mumps and rubella. (22173301)
2012
19
An ongoing large outbreak of measles in Merseyside, England, January to June 2012. (22835470)
2012
20
Measles virus IgG avidity assay for use in classification of measles vaccine failure in measles elimination settings. (22971778)
2012
21
Toll-like receptor 7 and 8 polymorphisms: associations with functional effects and cellular and antibody responses to measles virus and vaccine. (21947541)
2012
22
Measles virus glycoprotein-pseudotyped lentiviral vector-mediated gene transfer into quiescent lymphocytes requires binding to both SLAM and CD46 entry receptors. (21450813)
2011
23
IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome. (19890384)
2009
24
Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis. (19319188)
2009
25
Measles virus and CD46. (19198561)
2009
26
Elevated serum soluble E-selectin levels in Korean children with measles. (18937755)
2008
27
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20. (17720800)
2008
28
Semliki Forest virus vectors expressing the H and HN genes of measles and mumps viruses reduce immunity induced by the envelope protein genes of rubella virus. (17905485)
2007
29
Children's health and the social theory of risk: insights from the British measles, mumps and rubella (MMR) controversy. (17540488)
2007
30
Immunosuppression caused by measles virus: role of viral proteins. (16237742)
2006
31
Influence of HIV infection on changes in circulating leukocyte counts during measles in Zambian children. (16267766)
2005
32
Measles virus interacts with and alters signal transduction in T-cell lipid rafts. (15308747)
2004
33
Measles virus interacts with human SLAM receptor on dendritic cells to cause immunosuppression. (15193925)
2004
34
Combination therapy with intraventricular interferon-alpha and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR assay. (12850518)
2003
35
Restriction of measles virus RNA synthesis by a mouse host cell line: trans-complementation by polymerase components or a human cellular factor(s). (12021345)
2002
36
Human Herpesvirus 6 and Measles Virus employ distinct CD46 domains for receptor function. (12171934)
2002
37
Anterior uveitis following combined vaccination for measles, mumps and rubella (MMR): a report of two cases. (11037921)
2000
38
Measles virus-specific T helper 1/T helper 2-cytokine production in subacute sclerosing panencephalitis. (10822325)
2000
39
Revisited measles and chickenpox dynamics through orthogonal transformation. (10074391)
1999
40
Constitutive overexpression of the major inducible 70 kDa heat shock protein mediates large plaque formation by measles virus. (9747734)
1998
41
Gianotti-Crosti syndrome after measles, mumps and rubella vaccination. (9990393)
1998
42
Evidence that measles virus hemagglutinin initiates modulation of leukocyte function-associated antigen 1 expression. (7769697)
1995
43
Measles virus-specific immunoglobulin D antibody in cerebrospinal fluid and serum from patients with subacute sclerosing panencephalitis and multiple sclerosis. (2294143)
1990
44
Measles, mumps, rubella and chickenpox in the adult population. (2648205)
1989
45
Humoral and cellular immune responses to matrix protein of measles virus in subacute sclerosing panencephalitis. (3373575)
1988
46
A case of mycoplasmal pneumonia secondary to measles pneumonia. With some observations on 20 hospitalized patients with mycoplasmal pneumonia in 1984. (4066902)
1985
47
Response to live attenuated measles vaccine in children with severe kwashiorkor. (6191631)
1982
48
Measles and central nervous system disease. A critical appraisal. (4444685)
1974
49
Vaccination with measles and central nervous system disease. (5688849)
1968
50
Case of Necrosis of the Left Temporal Bone, involving Facial Nerve and Labyrinth, following Triple Infection of Scarlet Fever, Measles and Diphtheria, in a Child aged 7. (19983178)
1923

Genetic Variations for Measles

Expression for genes affiliated with Measles

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Measles

Search GEO for disease gene expression data for Measles.

Pathways for genes affiliated with Measles

Sources:
30KEGG, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN
See all sources

Pathways related to Measles according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2TLR3, IFNAR2, IFNB1, HLA-DMA, CD46, IL12B
2
Hide members
11.1IFNB1, MX1, CD40LG, CD46, HLA-DMA, TLR3
3
Hide members
10.9IRF1, MX1, IFNAR2, IFNB1, PTPN6
4
Immune response IFN alpha/beta signaling pathway
Hide members
10.9PTPN6, MX1, IRF1, IFNB1, IFNAR2
5
Hide members
10.9IFNB1, IFNAR2, IL12B, CCL4, TLR3
6
Hide members
10.8IL12B, CD40LG, HLA-DMA, IFNAR2
710.8IRF1, IFNB1, IFNAR2, TLR3
810.8IFNB1, IL12B, PTPN6, IFNAR2
9
Hide members
10.8IL12B, CD40LG, HLA-DMA, PTPN6

Compounds for genes affiliated with Measles

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Measles according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1tyrosine4512.1HLA-DMA, LBR, SCT, IRF1, IFNB1, IFNAR2
2lipid4511.9IFNAR2, LGALS4, PTPN6, MSN, IL12B, LBR
3calcium45 50 11 2414.9IL12B, CCL4, LGALS4, PTPN6, MSN, RNPC3
4serine4511.8LGALS4, PTPN6, MX1, RNPC3, CD46, RBP4
5retinoic acid45 2412.8PTPN6, CD40LG, RBP4, LBR, SCT, IRF1
6alanine4511.7MSN, IFNAR2, CCL4, IFNB1, RBP4, CD46
7phosphatidylinositol4511.7IFNAR2, TLR3, IRF1, CD46, SCT, IL12B
8oligonucleotide4511.6IRF1, RNPC3, MSN, PTPN6, HLA-DMA, SCT
9zinc45 2412.6LGALS4, RNPC3, PTPN6, MSN, RBP4, LBR
10rantes4511.6IL12B, CD40LG, CD46, LBR, SCT, IRF1
11cysteine4511.5RBP4, LBR, SCT, IFNB1, CCL4, PTPN6
12progesterone45 60 29 11 2415.5LGALS4, CCL4, IFNB1, LBR, RBP4, CD46
13arginine4511.4LBR, CD40LG, SCT, IRF1, GNLY, RNPC3
14nitric oxide45 11 2413.4TLR3, CCL4, IRF1, LBR, CD46, IL12B
15dexamethasone45 50 29 1114.4RBP4, LBR, IFNB1, CD40LG, TLR3, CD46
16cyclosporin a45 29 6013.3CCL4, RNPC3, CD40LG, CD46, LBR, SCT
172,5-oligoadenylate4511.3IFNB1, IRF1, MX1, IFNAR2, TLR3
18poly(i-c)4511.3MX1, IFNB1, TLR3, IL12B, IRF1
19thymidine45 2412.3LGALS4, PTPN6, LBR, SCT, IFNB1, IRF1
20ifn-alpha4511.3IFNAR2, TLR3, IRF1, MX1, IFNB1
21leucine4511.3LBR, HLA-DMA, RBP4, RNPC3, MX1, LGALS4
22adenylate4511.3CD40LG, RBP4, SCT, RNPC3, IFNB1, IRF1
23chloramphenicol45 2 1113.3IFNB1, LGALS4, MX1, IRF1, LBR
24cholesterol45 29 11 2414.2LBR, CCL4, IFNB1, GNLY, LGALS4, RBP4
25imiquimod45 29 60 1114.2IFNB1, IL12B, MX1, TLR3
26cycloheximide4511.2IFNB1, IRF1, MX1, MSN
27polyinosinic-polycytidylic acid4511.2IL12B, IRF1, IFNB1, TLR3
28steroid4511.2RBP4, LGALS4, CCL4, IFNB1, LBR, GNLY
29polysaccharide4511.2CD40LG, IFNB1, CCL4, LGALS4, CD46
30peptidoglycan45 2912.2IL12B, IFNB1, TLR3, CCL4
31ribavirin45 50 1113.2IFNB1, MX1, LBR, CD40LG
32neopterin4511.2MX1, CD40LG, LBR, IFNB1
33poly c4511.1RNPC3, TLR3, IFNB1
34thyroxine45 2412.1CD40LG, RBP4, SCT, IFNB1
35genistein45 29 60 2 11 2416.1LBR, CD40LG, PTPN6, LGALS4, IFNB1
36inosine monophosphate4511.0IRF1, IFNB1, TLR3
37lipoteichoic acid4511.0IL12B, TLR3, IFNB1
38ionomycin4511.0CCL4, LBR, GNLY, CD40LG
39endotoxin4511.0TLR3
40rebif4511.0IFNB1, MX1
41avonex4510.9MX1, IFNB1
42estrogen4510.9MSN
43ursodeoxycholic acid45 11 2412.9CD40LG, SCT, LBR
44estradiol45 11 2412.9IFNB1, GNLY
45il 104510.8IFNB1, CCL4, IL12B
46Alpha-D-Mannose1110.8IL12B, CD46, IFNB1
47ccl445 2911.7CCL4, IFNB1, IL12B
48betaseron4510.6IFNB1, MX1
49tobramycin4510.5RBP4, RNPC3
50ivig4510.4CD40LG, IFNB1, CCL4

GO Terms for genes affiliated with Measles

Sources:
16Gene Ontology
See all sources

Cellular components related to Measles according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.1IL12B, CD40LG, RBP4, GNLY, IFNB1, IFNAR2

Biological processes related to Measles according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1type I interferon-mediated signaling pathwayGO:06033711.1IRF1, MX1, PTPN6, IFNB1, IFNAR2
2defense response to virusGO:05160711.1IFNB1, IRF1, IL12B, MX1, TLR3
3cytokine-mediated signaling pathwayGO:01922111.1IFNAR2, PTPN6, MX1, IRF1, IFNB1
4positive regulation of interleukin-12 productionGO:03273510.9TLR3, CD40LG, IL12B
5response to virusGO:00961510.9IFNB1, IFNAR2, MX1, CCL4
6regulation of type I interferon-mediated signaling pathwayGO:06033810.8PTPN6, IFNB1, IFNAR2
7positive regulation of interferon-gamma biosynthetic processGO:04507810.6TLR3, IL12B
8natural killer cell activationGO:03010110.6IFNB1, IL12B
9B cell proliferationGO:04210010.5CD40LG, IFNB1
10defense response to bacteriumGO:04274210.4GNLY, TLR3, IFNB1

Molecular functions related to Measles according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.5TLR3, IFNAR2, IRF1, LBR, RBP4, MYBPH
2cytokine activityGO:00512510.5IL12B, CD40LG, IFNB1, CCL4

Products for genes affiliated with Measles

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Measles

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet