MCID: MSL001
MIFTS: 66

Measles malady

Infectious diseases category

Summaries for Measles

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Measles is an infectious disease caused by a virus. it spreads easily from person to person. the main symptom of measles is an itchy skin rash. the rash often starts on the head and moves down the body. other symptoms include fever cough runny nose conjunctivitis (pink eye) feeling achy and run down tiny white spots inside the mouth sometimes measles can lead to serious problems. there is no treatment for measles, but the measles-mumps-rubella (mmr) vaccine can prevent it. "german measles", also known as rubella, is a completely different illness. centers for disease control and prevention

MalaCards: Measles, also known as morbilli, is related to rubella and mumps, and has symptoms including maculopapular, conjunctivitis and coryza. An important gene associated with Measles is CD46 (CD46 molecule, complement regulatory protein), and among its related pathways are Influenza A and Immune System. The compounds tyrosine and lipid have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and brain, and related mouse phenotypes are immune system and cellular.

Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in measles virus, which is transmitted by contact with oronasal secretions, or semen of an infected person. the infection has symptom fever, has symptom cough, has symptom coryza, has symptom conjunctivitis, and has symptom maculopapular, erythematous rash.

CDC:3 Measles is a highly contagious respiratory disease caused by a virus. The disease of measles and the virus that causes it share the same name. The disease is also called rubeola.

Wikipedia:63 Measles, also known as morbilli, English measles, or rubeola (and not to be confused with rubella or... more...

Aliases & Classifications for Measles

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Measles

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17GeneCards, 18GeneDecks
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Diseases related to Measles via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 197)
idRelated DiseaseScoreTop Affiliating Genes
1rubella31.5RNPC3, CD40LG
2mumps31.5IRF1
3subacute sclerosing panencephalitis31.2IRF1, CD46, MX1, SLAMF1
4meningitis30.6CD46, CCL4
5hepatitis30.6TLR3, IFNB1, IRF1, CD40LG, MX1
6influenza30.5CCL4, TLR3, IFNB1, IRF1, LBR, HLA-DMA
7encephalitis30.5CCL4, TLR3, CD46, IL12B, MX1
8hepatitis b30.4TLR3, IFNAR2, IRF1, RNPC3, MX1
9multiple sclerosis30.4CCL4, TLR3, IFNAR2, IFNB1, IRF1, LBR
10encephalomyelitis30.4IFNB1, CCL4
11pneumonia30.3TLR3, IRF1, RBP4
12leukemia30.2LBR, IRF1, IFNB1, CCL4, RBP4, CD46
13neuritis30.2CCL4
14acute leukemia30.1IRF1, CD46, PTPN6
15ovarian cancer30.1TLR3, IFNB1, IRF1, LBR, RBP4, CD46
16asthma30.1TLR3, IFNB1, IRF1, SCT, LBR, IL12B
17arthritis30.0CCL4, TLR3, IRF1, MX1
18malaria30.0IL12B, RBP4
19hepatitis c29.9TLR3, IFNAR2, IFNB1, IRF1, RBP4, CD40LG
20tuberculosis29.9CCL4, IFNB1, GNLY, IRF1, LBR, IL12B
21pancreatitis29.9SCT
22breast cancer29.7LGALS4, CCL4, IFNAR2, IFNB1, IRF1, RBP4
23melanoma29.7CCL4, TLR3, IFNAR2, IFNB1, IRF1, LBR
24rheumatoid arthritis29.7CCL4, TLR3, IFNB1, LBR, HLA-DMA, CD40LG
25adenocarcinoma29.7IFNAR2, IFNB1, IRF1, SCT, CD46, MSN
26herpes simplex29.7TLR3, IFNB1, IRF1, LBR, IL12B, MX1
27hepatocellular carcinoma29.7TLR3, IFNAR2, IFNB1, IRF1, SCT, RBP4
28myeloma29.7CCL4, IFNAR2, IRF1, CD40LG
29newcastle disease29.7LBR, IRF1, IFNB1
30hemophagocytic lymphohistiocytosis29.7MX1, IFNB1
31biliary atresia29.7MX1
32toxic shock syndrome29.7LBR, CCL4
33pancreatic cancer29.7SCT
34diphtheria10.5
35scarlet fever10.4
36tetanus10.4
37otosclerosis10.3
38aseptic meningitis10.3
39pertussis10.3
40exanthem10.3
41chickenpox10.3
42hepatitis a10.3
43poliomyelitis10.3
44myelitis10.2
45neuronitis10.2
46acute disseminated encephalomyelitis10.2
47central nervous system disease10.2
48nervous system disease10.2
49dawson disease10.2
50bronchopneumonia10.2

Graphical network of the top 20 diseases related to Measles:



Diseases related to measles

Clinical Features for Measles

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Sources:
8Disease Ontology
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Symptoms:

8
  • maculopapular
  • conjunctivitis
  • coryza
  • cough
  • fever

Drugs & Therapeutics for Measles

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Measles

Drug clinical trials:

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Search NIH Clinical Center for Measles

Search CenterWatch for Measles

Genetic Tests for Measles

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Anatomical Context for Measles

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Measles:

32
Skin, Brain, Eye, T cells, Testes, B cells, Lung, Bone, Endothelial, Monocytes, Liver, Thyroid, Bone marrow, Myeloid, Tonsil, Prostate, Breast, Spinal cord

FMA organs/tissues related to Measles:

14
Skin

Animal Models for Measles or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Measles:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.3PTPN6, TLR3, IFNAR2, IFNB1, IRF1, LBR
2MP:000538411.2IRF1, LBR, HLA-DMA, RBP4, CD40LG, IL12B
3MP:000539711.1IFNAR2, IFNB1, IRF1, LBR, HLA-DMA, CD40LG
4MP:000537611.0TLR3, IFNAR2, IFNB1, IRF1, SCT, LBR

Publications for Measles

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Sources:
50PubMed
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Articles related to Measles:

(show top 50)    (show all 1186)
idTitleAuthorsYear
1
Measles and pertussis outbreaks: an important role for travel clinics. (23928029)
2013
2
Effect of early measles vaccination (AIK-C strain) for preterm infants. (23379893)
2013
3
A 60-year review on the changing epidemiology of measles in capital Beijing, China, 1951-2011. (24143899)
2013
4
Measles elimination: progress, challenges and implications for rubella control. (23984961)
2013
5
Risk factors for transmission of measles during an outbreak: matched case-control study. (24428975)
2013
6
Ongoing measles outbreak in Orthodox Jewish community, London, UK. (24050804)
2013
7
Characterizing the dynamics of rubella relative to measles: the role of stochasticity. (24026472)
2013
8
Progress in the elimination of measles and congenital rubella in Central Italy. (23292174)
2013
9
Experimental measles encephalitis in Lewis rats: dissemination of infected neuronal cell subtypes. (23996691)
2013
10
Attitudes towards the eradication of measles and CAM orientation of general physicians. Is there a direct link? A decision tree analysis. (24200827)
2013
11
Development of measles virus-based shielded oncolytic vectors: suitability of other paramyxovirus glycoproteins. (23306608)
2013
12
Decomposing Kenyan socio-economic inequalities in skilled birth attendance and measles immunization. (23294938)
2013
13
Measles as a reemerging disease. (23218609)
2013
14
Comparative evaluation of a new chemiluminiscent assay and an ELISA for the detection of IgM against measles. (24218130)
2013
15
Non-specific effects of diphtheria-tetanus-pertussis and measles vaccinations? An analysis of surveillance data from Navrongo, Ghana. (23006334)
2012
16
Gaps in the 2010 measles SIA coverage among migrant children in Beijing: evidence from a parental survey. (22819988)
2012
17
Replication of associations between cytokine and cytokine receptor single nucleotide polymorphisms and measles-specific adaptive immunophenotypic extremes. (22504412)
2012
18
Phosphorylation of measles virus phosphoprotein at S86 and/or S151 downregulates viral transcriptional activity. (23022562)
2012
19
Measles: a continuing saga. (22618983)
2012
20
Ongoing African measles virus genotype outbreak in Tel Aviv district since April, Israel, 2012. (22995430)
2012
21
Editorial commentary: A rare event: a measles outbreak in a population with high 2-dose measles vaccine coverage. (22543021)
2012
22
Susceptibility to measles, rubella, mumps, and varicella-zoster viruses among healthcare workers. (23291844)
2012
23
Measles: the burden of preventable deaths. (22534000)
2012
24
Current status of measles in the Republic of Korea: an overview of case-based and seroepidemiological surveillance scheme. (23300500)
2012
25
Subacute sclerosing panencephalitis in papua new guinean children: the cost of continuing inadequate measles vaccine coverage. (21245918)
2011
26
Antibody dynamics after tick-borne encephalitis and measles-mumps-rubella vaccination in children post early thymectomy. (20955827)
2010
27
Mechanisms of protein kinase PKR-mediated amplification of beta interferon induction by C protein-deficient measles virus. (19846517)
2010
28
Investigation of a mumps outbreak among university students with two measles-mumps-rubella (MMR) vaccinations, Virginia, September-December 2006. (19697404)
2009
29
Early onset optic neuritis following measles-rubella vaccination. (23479534)
2008
30
Contamination of reconstituted multidose measles vaccine vial and toxic shock syndrome in Tamilnadu. (18695289)
2008
31
Effects of interleukin-12 and interleukin-15 on measles-specific T-cell responses in vaccinated infants. (18419254)
2008
32
Congenital rubella syndrome in infants of women vaccinated during or just before pregnancy with measles-rubella vaccine. (18765873)
2008
33
Safety and immunogenicity of early vaccination with two doses of tetravalent measles-mumps-rubella-varicella (MMRV) vaccine in healthy children from 9 months of age. (17710370)
2007
34
Measles virus N protein inhibits host translation by binding to eIF3-p40. (17686838)
2007
35
Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE. (16858143)
2006
36
The use of a tropism-modified measles virus in folate receptor-targeted virotherapy of ovarian cancer. (17062694)
2006
37
Evaluation of the national immunisation programme in the Netherlands: immunity to diphtheria, tetanus, poliomyelitis, measles, mumps, rubella and Haemophilus influenzae type b. (12531347)
2003
38
V domain of human SLAM (CDw150) is essential for its function as a measles virus receptor. (11160657)
2001
39
Acute disseminated encephalomyelitis with probable measles vaccine failure. (10371390)
1999
40
Lennox-Gastaut syndrome after a further attenuated live measles vaccination. (10598060)
1999
41
Measles vaccine, inflammatory bowel disease and pervasive developmental disorder: is there cause for concern? (9616048)
1998
42
Is CD46 the cellular receptor for measles virus? (9140188)
1997
43
Nucleotide sequences of the M gene of prevailing wild measles viruses and a comparison with subacute sclerosing panencephalitis virus. (8879124)
1996
44
Glycosyl-phosphatidylinositol-anchored and transmembrane forms of CD46 display similar measles virus receptor properties: virus binding, fusion, and replication; down-regulation by hemagglutinin; and virus uptake and endocytosis for antigen presentation by major histocompatibility complex class II molecules. (7966579)
1994
45
Association of measles virus with neurofibrillary tangles in subacute sclerosing panencephalitis: a combined in situ hybridization and immunocytochemical investigation. (8072641)
1994
46
Functional analysis of matrix proteins expressed from cloned genes of measles virus variants that cause subacute sclerosing panencephalitis reveals a common defect in nucleocapsid binding. (8445713)
1993
47
Multiple viral mutations rather than host factors cause defective measles virus gene expression in a subacute sclerosing panencephalitis cell line. (3346948)
1988
48
Restricted expression of measles virus proteins in brains from cases of subacute sclerosing panencephalitis. (3537205)
1986
49
Protein-losing enteropathy and malabsorption in acute measles enteritis. (1131626)
1975
50
Section of Municipal Health Officers: EPIDEMIOLOGY OF DIPHTHERIA, SCARLET FEVER AND MEASLES. (19599586)
1911

Genetic Variations for Measles

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Expression for genes affiliated with Measles

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Measles

Search GEO for disease gene expression data for Measles.

Pathways for genes affiliated with Measles

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Sources:
29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Measles according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2MSN, TLR3, IFNAR2, IFNB1, HLA-DMA, CD46
2
Hide members
11.1TLR3, IFNAR2, IFNB1, IRF1, HLA-DMA, CD46
3
Hide members
10.9IFNAR2, IFNB1, IRF1, MX1, PTPN6
4
Immune response IFN alpha/beta signaling pathway
Hide members
10.9IFNAR2, IFNB1, IRF1, MX1, PTPN6
5
Hide members
10.9CCL4, TLR3, IFNAR2, IFNB1, IL12B
6
Hide members
10.8IL12B, CD40LG, HLA-DMA, IFNAR2
710.8IRF1, IFNB1, IFNAR2, TLR3
810.8IFNAR2, IFNB1, IL12B, PTPN6
9
Hide members
10.8HLA-DMA, CD40LG, IL12B, PTPN6

Compounds for genes affiliated with Measles

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Measles according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1tyrosine4412.1HLA-DMA, LBR, SCT, IRF1, IFNB1, IFNAR2
2lipid4411.9IFNAR2, LGALS4, PTPN6, MSN, IL12B, LBR
3calcium44 49 11 2414.9IL12B, CCL4, LGALS4, PTPN6, MSN, RNPC3
4serine4411.8LGALS4, PTPN6, MX1, RNPC3, CD46, RBP4
5retinoic acid44 2412.8PTPN6, CD40LG, RBP4, LBR, SCT, IRF1
6alanine4411.7MSN, IFNAR2, CCL4, IFNB1, RBP4, CD46
7phosphatidylinositol4411.7IFNAR2, TLR3, IRF1, CD46, SCT, IL12B
8oligonucleotide4411.6IRF1, RNPC3, MSN, PTPN6, HLA-DMA, SCT
9zinc44 2412.6LGALS4, RNPC3, PTPN6, MSN, RBP4, LBR
10rantes4411.6IL12B, CD40LG, CD46, LBR, SCT, IRF1
11cysteine4411.5RBP4, LBR, SCT, IFNB1, CCL4, PTPN6
12progesterone44 59 28 11 2415.5LGALS4, CCL4, IFNB1, LBR, RBP4, CD46
13arginine4411.4LBR, CD40LG, SCT, IRF1, GNLY, RNPC3
14nitric oxide44 11 2413.4TLR3, CCL4, IRF1, LBR, CD46, IL12B
15dexamethasone44 49 28 1114.4RBP4, LBR, IFNB1, CD40LG, TLR3, CD46
16cyclosporin a44 28 5913.3CCL4, RNPC3, CD40LG, CD46, LBR, SCT
172,5-oligoadenylate4411.3IFNB1, IRF1, MX1, IFNAR2, TLR3
18poly(i-c)4411.3MX1, IFNB1, TLR3, IL12B, IRF1
19thymidine44 2412.3LGALS4, PTPN6, LBR, SCT, IFNB1, IRF1
20ifn-alpha4411.3IFNAR2, TLR3, IRF1, MX1, IFNB1
21leucine4411.3LBR, HLA-DMA, RBP4, RNPC3, MX1, LGALS4
22adenylate4411.3CD40LG, RBP4, SCT, RNPC3, IFNB1, IRF1
23chloramphenicol44 2 1113.3IFNB1, LGALS4, MX1, IRF1, LBR
24cholesterol44 28 11 2414.2LBR, CCL4, IFNB1, GNLY, LGALS4, RBP4
25imiquimod44 28 59 1114.2IFNB1, IL12B, MX1, TLR3
26cycloheximide4411.2IFNB1, IRF1, MX1, MSN
27polyinosinic-polycytidylic acid4411.2IL12B, IRF1, IFNB1, TLR3
28steroid4411.2RBP4, LGALS4, CCL4, IFNB1, LBR, GNLY
29polysaccharide4411.2CD40LG, IFNB1, CCL4, LGALS4, CD46
30peptidoglycan44 2812.2IL12B, IFNB1, TLR3, CCL4
31ribavirin44 49 1113.2IFNB1, MX1, LBR, CD40LG
32neopterin4411.2MX1, CD40LG, LBR, IFNB1
33poly c4411.1RNPC3, TLR3, IFNB1
34thyroxine44 2412.1CD40LG, RBP4, SCT, IFNB1
35genistein44 28 59 2 11 2416.1LBR, CD40LG, PTPN6, LGALS4, IFNB1
36inosine monophosphate4411.0IRF1, IFNB1, TLR3
37lipoteichoic acid4411.0IL12B, TLR3, IFNB1
38ionomycin4411.0CCL4, LBR, GNLY, CD40LG
39endotoxin4411.0TLR3
40rebif4411.0IFNB1, MX1
41avonex4410.9MX1, IFNB1
42estrogen4410.9MSN
43ursodeoxycholic acid44 11 2412.9CD40LG, SCT, LBR
44estradiol44 11 2412.9IFNB1, GNLY
45il 104410.8IFNB1, CCL4, IL12B
46Alpha-D-Mannose1110.8IL12B, CD46, IFNB1
47ccl444 2811.7CCL4, IFNB1, IL12B
48betaseron4410.6IFNB1, MX1
49tobramycin4410.5RBP4, RNPC3
50ivig4410.4CD40LG, IFNB1, CCL4

GO Terms for genes affiliated with Measles

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16Gene Ontology
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Cellular components related to Measles according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.1IL12B, CD40LG, RBP4, GNLY, IFNB1, IFNAR2

Biological processes related to Measles according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1type I interferon-mediated signaling pathwayGO:06033711.1PTPN6, MX1, IRF1, IFNB1, IFNAR2
2defense response to virusGO:05160711.1TLR3, IFNB1, IRF1, IL12B, MX1
3cytokine-mediated signaling pathwayGO:01922111.1PTPN6, MX1, IRF1, IFNB1, IFNAR2
4positive regulation of interleukin-12 productionGO:03273510.9TLR3, CD40LG, IL12B
5response to virusGO:00961510.9CCL4, IFNAR2, IFNB1, MX1
6regulation of type I interferon-mediated signaling pathwayGO:06033810.8PTPN6, IFNB1, IFNAR2
7positive regulation of interferon-gamma biosynthetic processGO:04507810.6TLR3, IL12B
8natural killer cell activationGO:03010110.6IL12B, IFNB1
9B cell proliferationGO:04210010.5IFNB1, CD40LG
10defense response to bacteriumGO:04274210.4GNLY, IFNB1, TLR3

Molecular functions related to Measles according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.5TLR3, IFNAR2, IRF1, LBR, RBP4, MYBPH
2cytokine activityGO:00512510.5IL12B, CD40LG, IFNB1, CCL4

Products for genes affiliated with Measles

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Measles

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet