MCID: MCK002
MIFTS: 32

Meckel's Diverticulum malady

Gastrointestinal category

Summaries for Meckel's Diverticulum

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 A Meckel\'s diverticulum, a true congenital diverticulum, is a slight bulge in the small intestine... more...

MalaCards: Meckel's Diverticulum, also known as meckel diverticulum, is related to appendicitis and intussusception. An important gene associated with Meckel's Diverticulum is FOXA2 (forkhead box A2). The compounds c-peptide and guanidine have been mentioned in the context of this disorder. Affiliated tissues include kidney, spleen and small intestine.

Description from OMIM:47 155140

Aliases & Classifications for Meckel's Diverticulum

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt, 47OMIM, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

meckel's diverticulum 8
meckel diverticulum 8 61
persistent vitelline duct 8


External Ids:

Disease Ontology8 DOID:9487
NCIt40 C12264
OMIM47 155140
MeSH35 D008467
ICD9CM27 751.0
ICD1025 Q43.0

Related Diseases for Meckel's Diverticulum

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Meckel's Diverticulum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1appendicitis30.1CTRC
2intussusception10.4
3type vi ehlers-danlos syndrome10.3
4ehlers–danlos syndrome10.3
5gastrointestinal stromal tumor10.1
6desmoplastic small round cell tumor10.1
7fanconi anemia, complementation group c10.1
8pericardial and diaphragmatic defect10.1
9gastric ulcer10.0HRH2
10glucose intolerance10.0SERPINE1, PPP1R3A
11type 2 diabetes mellitus10.0SERPINE1, PPP1R3A, FOXA2

Graphical network of diseases related to Meckel's Diverticulum:



Diseases related to meckel's diverticulum

Clinical Features for Meckel's Diverticulum

Sources:
47OMIM
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Clinical features from OMIM:

155140

Drugs & Therapeutics for Meckel's Diverticulum

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Meckel's Diverticulum

Drug clinical trials:

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Search NIH Clinical Center for Meckel's Diverticulum

Search CenterWatch for Meckel's Diverticulum

Genetic Tests for Meckel's Diverticulum

Anatomical Context for Meckel's Diverticulum

Sources:
33MalaCards
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MalaCards organs/tissues related to Meckel's Diverticulum:

33
Kidney, Spleen, Small intestine, Colon, Pancreas, Appendix

Animal Models for Meckel's Diverticulum or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Meckel's Diverticulum

Sources:
51PubMed
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Articles related to Meckel's Diverticulum:

(show top 50)    (show all 170)
idTitleAuthorsYear
1
Successful endoscopic resection of inverted Meckel's diverticulum by double-balloon enteroscopy. (23022701)
2013
2
Invaginated Meckel's diverticulum: a rare cause of small intestine intussusception in adults. (23552542)
2013
3
Perforation of Meckel's diverticulum by a wood splinter in a 4-year-old child: a case report. (23976900)
2013
4
Phytobezoar in Meckel's diverticulum: A rare cause of small bowel obstruction. (22382033)
2012
5
Strangulated paraumbilical hernia-An unusual complication of a Meckel's diverticulum. (22459265)
2012
6
Gangrenous Meckel's diverticulum secondary to ascariasis in a child. (23507841)
2012
7
Synchronous association of two neuroendocrine gastroenteropancreatic tumors, an adenocarcinoma of the cecum, and a Meckel's diverticulum: a case report. (22495724)
2012
8
Surgical conduct in case of intraoperative detection of a Meckel's diverticulum in Crohn's disease. (22115390)
2011
9
Intussusception Secondary to a Meckel's Diverticulum in an Adolescent. (23326695)
2011
10
Clinical profile and surgical outcome of Meckel's diverticulum. (22315842)
2011
11
National trends in the surgical management of Meckel's diverticulum. (21616248)
2011
12
A clinically-occult gastrointestinal stromal tumor in a Meckel's diverticulum presenting as hollow organ perforation. (22490461)
2011
13
A gastrointestinal stromal tumor in Meckel diverticulum in an 86-year-old patient. (20562591)
2010
14
Small Bowel Obstruction due to Mesodiverticular Band of Meckel's Diverticulum: A Case Report. (20814563)
2010
15
Successful treatment of gastric adenocarcinoma in a Meckel's diverticulum with pemetrexed plus carboplatin. (20534684)
2010
16
Delayed imaging of Meckel's diverticulum: observation of a quadrantal shift. (19092389)
2009
17
Meckel's diverticulum masked by a long period of intermittent recurrent subocclusive episodes. (19522035)
2009
18
An adult case of celiac sprue triggered after an ileal resection for perforated Meckel's diverticulum. (19705507)
2009
19
Neonatal Meckel's diverticulum: spectrum of presentation. (19444035)
2009
20
A gastrointestinal stromal tumour presenting incidentally with haemorrhage and perforation associated with a Meckel's diverticulum: a case report. (19830205)
2009
21
Meckel's diverticulum in infants and children; technetium-99m pertechnetate scintigraphy and clinical findings. (18392223)
2008
22
Gastrointestinal: strangulated Meckel's diverticulum. (19120883)
2008
23
Gastrointestinal stromal tumour in Meckel's diverticulum. (17498311)
2007
24
High incidence of symptomatic Meckel's diverticulum in patients less than fifty years of age: an indication for resection. (17375785)
2007
25
An unusual manifestation of Meckel's diverticulum: strangulated paraumbilical hernia. (16807577)
2006
26
Laparoscopy-assisted surgical management of obscure gastrointestinal bleeding secondary to Meckel's diverticulum in a pediatric patient: case report and review of literature. (16340574)
2005
27
Meckel's diverticulum masked by a long period of gastric symptoms--a case report. (16184729)
2005
28
Bleeding stromal tumor in Meckel's diverticulum. (16038218)
2005
29
Meckel's diverticulum mimicking small bowel tumor. (15278059)
2004
30
Rare mesenteric location of Meckel's diverticulum, a forgotten entity: a case study aboard USS Kitty Hawk. (15586511)
2004
31
Spontaneous haemoperitoneum secondary to a Meckel's diverticulum. (15571033)
2004
32
Stromal tumor in a perforated Meckel's diverticulum: a case report. (12520847)
2002
33
Gangrene secondary to axial torsion in a patient with Meckel's diverticulum. (12222911)
2002
34
Gastrointestinal bleeding in adult patients with Meckel's diverticulum: the role of technetium 99m pertechnetate scan. (12540005)
2002
35
Surgical management and complications of Meckel's diverticulum in 90 patients. (12022375)
2002
36
The role of heterotopic gastric mucosa with or without colonization of Helicobacter pylori upon the diverse symptomatology of Meckel's diverticulum in children. (11765161)
2001
37
Meckel's diverticulum: review and surgical management. (16093063)
2001
38
Stromal tumour within a Meckel's diverticulum: CT and ultrasound findings. (11777773)
2001
39
Meckel's diverticulum mimicking infantile colic: sonographic detection. (10867673)
2000
40
Procedure guideline for gastrointestinal bleeding and Meckel's diverticulum scintigraphy. Society of Nuclear Medicine. (10405149)
1999
41
Strangulated Meckel's diverticulum. (9854527)
1998
42
Spontaneous perforation of Meckel's diverticulum in a neonate. (10216603)
1998
43
Malignant stromal tumor consistent with fibrosarcoma arising from Meckel's diverticulum. Clinicopathological study of an incidentally discovered tumor and review of the literature. (9267492)
1997
44
Laparoscopic evaluation and management of a child with ambiguous genitalia, ectopic spleen, and Meckel's diverticulum. (9170226)
1997
45
Intussusception secondary to Meckel's diverticulum detection with Tc-99m monoclonal antibodies to granulocytes (Leukoscan). (8922842)
1996
46
The value of sodium pertechnetate Tc99m scans in the diagnosis of Meckel's diverticulum. (24057627)
1996
47
Cystlike Meckel's diverticulum: sonographic findings. (8956611)
1996
48
Meckel's diverticulum. Internal hernia and adhesions without gastrointestinal bleeding--ultrasound and scintigraphic findings. (8957607)
1996
49
Carcinoid syndrome secondary to a primary tumour in a Meckel's diverticulum. (8363487)
1993
50
Intestinal neoplasm mimicking a Meckel's diverticulum on scintigraphic imaging. (1646093)
1991

Genetic Variations for Meckel's Diverticulum

Expression for genes affiliated with Meckel's Diverticulum

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meckel's Diverticulum

Search GEO for disease gene expression data for Meckel's Diverticulum.

Pathways for genes affiliated with Meckel's Diverticulum

Compounds for genes affiliated with Meckel's Diverticulum

Sources:
45Novoseek, 11DrugBank, 24HMDB
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Compounds related to Meckel's Diverticulum according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1c-peptide459.7SERPINE1, FOXA2
2guanidine45 11 2411.3SERPINE1, HRH2

GO Terms for genes affiliated with Meckel's Diverticulum

Sources:
16Gene Ontology
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Biological processes related to Meckel's Diverticulum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin modificationGO:0165689.5HDAC11, FOXA2

Products for genes affiliated with Meckel's Diverticulum

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Meckel's Diverticulum

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet