MCID: MCK002
MIFTS: 40

Meckel's Diverticulum malady

Gastrointestinal diseases category
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Summaries for Meckel's Diverticulum

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Sources:
65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 A Meckel\'s diverticulum, a true congenital diverticulum, is a slight bulge in the small intestine... more...

MalaCards: Meckel's Diverticulum, also known as meckel diverticulum, is related to intussusception and meckel's diverticulum cancer. An important gene associated with Meckel's Diverticulum is FOXA2 (forkhead box A2). The compounds c-peptide and guanidine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and bone, and related mouse phenotypes are tumorigenesis and adipose tissue.

Description from OMIM:47 155140

Aliases & Classifications for Meckel's Diverticulum

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 47OMIM, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

meckel's diverticulum 8
meckel diverticulum 8 62
persistent vitelline duct 8


External Ids:

Disease Ontology8 DOID:9487
OMIM47 155140
MeSH35 D008467
ICD9CM27 751.0
NCIt40 C12264
ICD1025 Q43.0

Related Diseases for Meckel's Diverticulum

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Meckel's Diverticulum:



Diseases related to meckel's diverticulum

Symptoms for Meckel's Diverticulum

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47OMIM
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Clinical features from OMIM:

155140

Drugs & Therapeutics for Meckel's Diverticulum

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Meckel's Diverticulum

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Anatomical Context for Meckel's Diverticulum

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33MalaCards
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MalaCards organs/tissues related to Meckel's Diverticulum:

33
Small intestine, Colon, Bone, Pancreas, Appendix, Liver, Spleen, Kidney

Animal Models for Meckel's Diverticulum or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Meckel's Diverticulum:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.3FOXA2, SERPINE1
2MP:00053759.0FOXA2, SERPINE1
3MP:00053768.4HRH2, FOXA2, SERPINE1

Publications for Meckel's Diverticulum

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52PubMed
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Articles related to Meckel's Diverticulum:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
Double-balloon enteroscopy for the diagnosis of Meckel's diverticulum in pediatric patients with obscure GI bleeding. (24016356)
2014
2
Perforated Meckel's Diverticulum in a Very Preterm Baby Revealed at Birth. (24328940)
2013
3
LittrAc meets de Garengeot: Meckel's diverticulum and appendix in a femoral hernia. (24025278)
2013
4
Mesenteric Meckel's diverticulum. (23934471)
2013
5
Adenocarcinoma arising from Meckel's diverticulum in the ileum with malrotation of the midgut. (23741695)
2013
6
Hereditary diffuse gastric cancer: the always-forgotten Meckel's diverticulum. (22240148)
2012
7
Detection of a polypoid lesion inside a Meckel's diverticulum using wireless capsule endoscopy. (21425002)
2011
8
Meckel's diverticulum with small bowel obstruction presenting as appendicitis in a pediatric patient. (22643517)
2011
9
Meckel's diverticulum-Revisited. (20065566)
2010
10
Haemoperitoneum caused by perforation of Meckel's diverticulum in a 5-year-old child. (22767689)
2010
11
Meckel's diverticulum with gastrointestinal bleeding: role of computed tomography in diagnosis. (19888654)
2010
12
Ileo-ileal intussusception due to inverted Meckel's diverticulum. (19803269)
2009
13
Pancreas transplant and incidental Meckel's diverticulum: not always a straightforward decision. (19563483)
2009
14
Detection of splenomegaly on Meckel's diverticulum scan. (19352291)
2009
15
Perforation of Meckel's diverticulum by a fishbone. (18959720)
2008
16
Crohn's disease in a Meckel's diverticulum: report of a case. (17579870)
2008
17
Endoscopic observation of Meckel's diverticulum by double balloon endoscopy: report of five cases. (17931373)
2008
18
Meckel's diverticulum in infants and children; technetium-99m pertechnetate scintigraphy and clinical findings. (18392223)
2008
19
Electronic clinical challenges and images in GI. Meckel's diverticulum. (18395064)
2008
20
A loop formation of Meckel's diverticulum causes intestine ischemia. (18449970)
2008
21
Intrauterine fistulation of perforated Meckel's diverticulum to the surface of the sac of an intact exomphalos minor. (18449142)
2008
22
Perforated Meckel's diverticulum in a child after blunt abdominal trauma. (16983299)
2007
23
Penetrating ectopic peptic ulcer in the absence of Meckel's diverticulum ultimately presenting as small bowel obstruction. (18069775)
2007
24
Adenocarcinoma of the appendix and a Meckel's diverticulum in a case of acute appendicitis. (17848820)
2007
25
Case report: Concurrent congenital complete atrioventricular block, Meckel's diverticulum and cerebral palsy in a 19-year-old male. (17582526)
2007
26
An unusual manifestation of Meckel's diverticulum: strangulated paraumbilical hernia. (16807577)
2006
27
Pre-operative diagnosis of Meckel's diverticulum: report of a case and review of literature. (16225058)
2005
28
Laparoscopy-assisted surgical management of obscure gastrointestinal bleeding secondary to Meckel's diverticulum in a pediatric patient: case report and review of literature. (16340574)
2005
29
A fading Meckel's diverticulum: an unusual scintigraphic appearance in a child. (14534756)
2004
30
Medical image. Bleeding Meckel's diverticulum diagnosed with enterocolysis and mesenteric angiography. (15505675)
2004
31
Migrating calcified enterolith and chronic anemia: an unusual case presentation of a Meckel's diverticulum. (15630649)
2004
32
Laparoscopic management of Meckel's diverticulum in adults. (12582775)
2003
33
Laparoscopic reduction of an ileoileal intussusception and resection of an inverted Meckel's diverticulum in an adult. (12728389)
2003
34
Carcinoid tumor in a Meckel's diverticulum: hypothesis on mutual embryological origin. (12731730)
2003
35
Role of Helicobacter pylori infection in complications from Meckel's diverticulum. (12822864)
2003
36
Bowel obstruction caused by a Meckel's diverticulum enterolith: a case report and review of the literature. (14972313)
2003
37
Inverted Meckel's diverticulum as a cause of obscure lower gastrointestinal bleeding. (12971879)
2003
38
Stromal tumor in a perforated Meckel's diverticulum: a case report. (12520847)
2002
39
Vesicoenteric fistula created by ingested foreign body in Meckel's diverticulum. (12441969)
2002
40
Laparoscopic management of Meckel's diverticulum. (16093064)
2001
41
Bleeding Meckel's diverticulum in an adult. (11813588)
2001
42
Axial torsion of Meckel's diverticulum presenting as a pelvic mass. (11727027)
2001
43
Digestive hemorrhage caused by a Meckel's diverticulum in a metformin-treated patient: is there any connection? (11468878)
2001
44
A Meckel's diverticulum containing pancreatic tissue and nesidioblastosis in a patient with Beckwith-Wiedemann syndrome. (10663860)
2000
45
Ischemic Meckel's diverticulum and acute appendicitis. (10812353)
2000
46
Sodium pertechnetate scintigraphy in detection of Meckel's diverticulum: is it usable? (11034511)
2000
47
Characteristic angiographic appearance of inverted Meckel's diverticulum. (9393167)
1997
48
Laparoscopy: the ultimate diagnostic tool for a bleeding Meckel's diverticulum. (9137168)
1997
49
Bleeding Meckel's diverticulum. (8599800)
1996
50
Meckel's diverticulum: possible detection by combining pentagastrin with histamine H2 receptor blocker. (7931667)
1994

Variations for Meckel's Diverticulum

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Expression for genes affiliated with Meckel's Diverticulum

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meckel's Diverticulum

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Pathways for genes affiliated with Meckel's Diverticulum

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Compounds for genes affiliated with Meckel's Diverticulum

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR
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Compounds related to Meckel's Diverticulum according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1c-peptide459.5FOXA2, SERPINE1
2guanidine45 24 1111.4HRH2, SERPINE1
35-hydroxytryptamine459.3SERPINE1, HRH2
4endotoxin459.3HRH2, SERPINE1
5isoproterenol45 1110.2HRH2, SERPINE1
6aspirin45 51 29 2412.2SERPINE1, HRH2
7creatinine459.1HRH2, SERPINE1
8nitric oxide45 24 1111.1HRH2, SERPINE1
9adenylate459.0HRH2, SERPINE1
10cholesterol45 29 24 1111.8HRH2, SERPINE1

GO Terms for genes affiliated with Meckel's Diverticulum

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16Gene Ontology
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Biological processes related to Meckel's Diverticulum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:0459449.3FOXA2, SERPINE1

Products for genes affiliated with Meckel's Diverticulum

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  • Antibodies
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Sources for Meckel's Diverticulum

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet