MCID: MCK002
MIFTS: 35

Meckel's Diverticulum

Categories: Gastrointestinal diseases

Aliases & Classifications for Meckel's Diverticulum

MalaCards integrated aliases for Meckel's Diverticulum:

Name: Meckel's Diverticulum 12 14
Meckel Diverticulum 12 29 42 69
Persistent Vitelline Duct 12

Characteristics:

HPO:

32
meckel's diverticulum:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Meckel's Diverticulum

MalaCards based summary : Meckel's Diverticulum, also known as meckel diverticulum, is related to meckel's diverticulum cancer and small intestine leiomyosarcoma, and has symptoms including meckel diverticulum An important gene associated with Meckel's Diverticulum is FOXA2 (Forkhead Box A2), and among its related pathways/superpathways is Cardiac Progenitor Differentiation. Affiliated tissues include small intestine, bone and colon, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 72 A Meckel\'s diverticulum, a true congenital diverticulum, is a slight bulge in the small intestine... more...

Related Diseases for Meckel's Diverticulum

Diseases related to Meckel's Diverticulum via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
id Related Disease Score Top Affiliating Genes
1 meckel's diverticulum cancer 11.4
2 small intestine leiomyosarcoma 10.1
3 omphalomesenteric cyst 10.1
4 squamous cell carcinoma of the small intestine 10.1
5 intussusception 10.0
6 ehlers-danlos syndrome, type iv 9.9
7 ehlers-danlos syndrome 9.9
8 gastrointestinal stromal tumor 9.7
9 neuroendocrine tumor 9.7
10 gastroenteritis 9.7
11 cystic teratoma 9.7
12 teratoma 9.7
13 appendicitis 9.7
14 intestinal obstruction 9.7
15 desmoplastic small round cell tumor 9.7
16 pulmonary eosinophilia 6.7 ACOT7 CLMP FLG2 FOXA2 FOXM1 HRH2

Graphical network of the top 20 diseases related to Meckel's Diverticulum:



Diseases related to Meckel's Diverticulum

Symptoms & Phenotypes for Meckel's Diverticulum

Human phenotypes related to Meckel's Diverticulum:

32
id Description HPO Frequency HPO Source Accession
1 meckel diverticulum 32 HP:0002245

MGI Mouse Phenotypes related to Meckel's Diverticulum:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 CLMP FOXA2 FOXM1 HRH2 KIT SERPINE1
2 liver/biliary system MP:0005370 9.55 ACOT7 FOXA2 FOXM1 KIT SERPINE1
3 neoplasm MP:0002006 9.26 FOXA2 FOXM1 KIT SERPINE1
4 respiratory system MP:0005388 8.92 FOXA2 FOXM1 KIT SERPINE1

Drugs & Therapeutics for Meckel's Diverticulum

Search Clinical Trials , NIH Clinical Center for Meckel's Diverticulum

Cochrane evidence based reviews: meckel diverticulum

Genetic Tests for Meckel's Diverticulum

Genetic tests related to Meckel's Diverticulum:

id Genetic test Affiliating Genes
1 Meckel Diverticulum 29

Anatomical Context for Meckel's Diverticulum

MalaCards organs/tissues related to Meckel's Diverticulum:

39
Small Intestine, Bone, Colon, Pancreas, Appendix, Liver, Kidney

Publications for Meckel's Diverticulum

Articles related to Meckel's Diverticulum:

(show top 50) (show all 639)
id Title Authors Year
1
Meckel's diverticulum in the adult. ( 28698005 )
2017
2
Perforation of Meckel's diverticulum with a foreign body mimicking acute appendicitis: A rare complication. ( 28585600 )
2017
3
Bleeding Meckel's Diverticulum in Children: The Diagnostic Value of Double-Balloon Enteroscopy. ( 28421109 )
2017
4
A faster and simpler way of operation for Meckel's diverticulum: basal ligation combined with intraoperative frozen section. ( 28916856 )
2017
5
Urachal Cyst, Meckel's Diverticulum and Band, and Urachus. ( 28164005 )
2017
6
Littre Hernia: A Rare Case of an Incarcerated Meckel's Diverticulum. ( 28597002 )
2017
7
Meckel's Diverticulum Enterolith: An Extremely Rare Cause of Intestinal Obstruction. ( 28571210 )
2017
8
Giant Meckel's diverticulum compressing root of mesentery - A rare cause of ileal gangrene - Case report and review of literature. ( 28735118 )
2017
9
Perforated Meckel's Diverticulum causing Intussusception in a Neonate. ( 28920033 )
2017
10
Enterovesical fistula, a rare complication of Meckel's diverticulum: A case report. ( 28732299 )
2017
11
Male predominance in Meckel's diverticulum: A hyperacidity hypotheses. ( 28673591 )
2017
12
Meckel's diverticulitis: a rare entity of Meckel's diverticulum. ( 28064243 )
2017
13
Angiographic diagnosis of Meckel's diverticulum in an adult patient with negative scintigraphy. ( 28584569 )
2017
14
Left-Sided Gastroschisis with Meckel's Diverticulum: A Rare Presentation. ( 28920030 )
2017
15
Meckel's diverticulum - a congenital defect of the gastrointestinal tract underestimated in differential diagnostics. Own experience. ( 28551691 )
2017
16
Laparoscopic resection for Meckel's diverticulum causing intestinal obstruction. ( 28944341 )
2017
17
Large Meckel's Diverticulum and Dilated Adjacent Small Intestine Presenting With Intestinal Obstruction. ( 28899672 )
2017
18
Torsion of Atypical Meckel's Diverticulum Treated by Laparoscopic-Assisted Surgery. ( 28785284 )
2017
19
Adenocarcinoma Ex-Goblet Cell Carcinoid of the Appendix With Metastatic Peritoneal Spread to Meckel's Diverticulum and Endometriosis. ( 28449607 )
2017
20
Perforated Meckel's diverticulum. ( 28731997 )
2017
21
A Rare Entity of Gastrointestinal Stromal Tumour Arising from a Meckel's Diverticulum: a Case Report. ( 28092014 )
2017
22
Protein-losing Enteropathy Caused by Spontaneous Reduction of Intussusception with Meckel's Diverticulum. ( 28413865 )
2017
23
Gastrointestinal stromal tumor of the vermiform appendix mimicking Meckel's diverticulum: Case report with literature review. ( 26895113 )
2016
24
Inverted Meckel's Diverticulum with Intussusception and Ulceration Diagnosed after Rectal Double-Balloon Enteroscopy. ( 28008404 )
2016
25
Gallstone ileus associated with impaction at Meckel's diverticulum: Case report and literature review. ( 27933137 )
2016
26
An unusual case of intraabdominal abscess and acute abdomen caused by axial torsion of a Meckel's diverticulum. ( 26955478 )
2016
27
Laparoscopic surgery for small-bowel obstruction caused by Meckel's diverticulum. ( 26981191 )
2016
28
Diagnostic laparoscopy for neonatal perforated Meckel's diverticulum. ( 26917924 )
2016
29
Hemorrhagic Meckel's diverticulum. Interest of the digestive pertechnetate scintigraphy. ( 28685802 )
2016
30
Phytobezoar impaction in a Meckel's diverticulum; a rare cause of bowel obstruction: Case report and review of literature. ( 28012337 )
2016
31
Comorbid Meckel's diverticulum and omphalomesenteric cyst evaluated by small bowel series under double-balloon enteroscopy:a case report. ( 27052394 )
2016
32
Adult Intussusception Caused by Inverted Meckel's Diverticulum Containing Mesenteric Heterotopic Pancreas and Smooth Muscle Bundles. ( 27498547 )
2016
33
Laparoscopic management of an axially torsed gangrenous Meckel's diverticulum in a child. ( 27502885 )
2016
34
Incremental value of SPECT/CT in detection of Meckel's diverticulum in a 10-year-old child. ( 27540503 )
2016
35
Meckel's diverticulum and bowel obstruction due to phytobezoar: a case report. ( 27345602 )
2016
36
Meckel's diverticulum in children: Our 12-year experience. ( 28051045 )
2016
37
A gastrointestinal stromal tumor found in perforated Meckel's diverticulum. ( 27411534 )
2016
38
Perforated Meckel's diverticulum containing a carcinoid tumor successfully treated by the laparoscopic approach: Case report. ( 27251847 )
2016
39
Diagnosis of Bleeding Meckel's Diverticulum in Adults. ( 27626641 )
2016
40
Meckel's diverticulum enteroliths causing small bowel obstruction. ( 26762683 )
2016
41
Intestinal hemorrhage caused by Meckel's diverticulum with ectopic gastric mucosa on polypoid lesion: a case report. ( 27815920 )
2016
42
The many faces of Meckel's diverticulum and its complications. ( 27492813 )
2016
43
Pediatric Meckel's Diverticulum: Report of 208 Cases and Review of the Literature. ( 27064958 )
2016
44
Intestinal Duplication Cyst Misdiagnosed as Meckel's Diverticulum. ( 26830996 )
2016
45
Mesenteric Meckel's diverticulum or intestinal duplication cyst: A case report with review of literature. ( 27449764 )
2016
46
A massive bleeding from a gastrointestinal stromal tumor of a Meckel's diverticulum. ( 27483571 )
2016
47
A curious case of Meckel's diverticulum. ( 27770121 )
2016
48
Traumatic rupture of a Meckel's diverticulum due to blunt abdominal trauma in a soccer game: A case report. ( 26701844 )
2016
49
Many faces of Meckel's diverticulum and its complications. ( 26932405 )
2016
50
Perforated Gastrointestinal Stromal Tumor of the Meckel's Diverticulum: a Case Report and Review of Literature. ( 27994335 )
2016

Variations for Meckel's Diverticulum

Expression for Meckel's Diverticulum

Search GEO for disease gene expression data for Meckel's Diverticulum.

Pathways for Meckel's Diverticulum

Pathways related to Meckel's Diverticulum according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.35 FOXA2 KIT

GO Terms for Meckel's Diverticulum

Biological processes related to Meckel's Diverticulum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 visual learning GO:0008542 8.96 HRH2 KIT
2 digestive tract development GO:0048565 8.8 CLMP HRH2 KIT

Molecular functions related to Meckel's Diverticulum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 KIT SERPINE1

Sources for Meckel's Diverticulum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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