MAS
MCID: MCN007
MIFTS: 57

Meconium Aspiration Syndrome (MAS) malady

Rare diseases, Fetal diseases, Respiratory diseases categories
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Summaries for Meconium Aspiration Syndrome

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Meconium aspiration syndrome is a serious condition in which a newborn breathes a mixture of meconium and amniotic fluid into the lungs around the time of delivery. this can cause breathing difficulties due to swelling (inflammation) in the baby's lungs after birth. treatment may include suctioning the newborn's mouth as soon as the head emerges during delivery, deep suctioning of the windpipe, antibiotics to treat infection, oxygen to keep blood levels normal, and radiant heat to maintain body temperature. in severe cases, the baby may need assistance breathing (ventilator). last updated: 1/12/2012

MalaCards: Meconium Aspiration Syndrome, also known as neonatal aspiration, unspecified, is related to respiratory failure and sepsis. An important gene associated with Meconium Aspiration Syndrome is SFTPB (surfactant protein B), and among its related pathways are PEDF Induced Signaling and PAK Pathway. The compounds popg and romurtide have been mentioned in the context of this disorder. Affiliated tissues include lung and uterus, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Wikipedia:65 Meconium aspiration syndrome (MAS, alternatively \"Neonatal aspiration of meconium\") is a medical... more...

Aliases & Classifications for Meconium Aspiration Syndrome

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

49
meconium aspiration syndrome:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

meconium aspiration syndrome 8 43 10 45 49 62
neonatal aspiration, unspecified 62
neonatal aspiration of meconium 8
meconium aspiration 8
mas 43


External Ids:

Disease Ontology8 DOID:11049
NCIt40 C87093
MeSH35 D008471
MESH via Orphanet36 D008471
ICD10 via Orphanet26 P24.0
SNOMED-CT via Orphanet59 206292002
UMLS via Orphanet63 C0025048

Related Diseases for Meconium Aspiration Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Meconium Aspiration Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1respiratory failure30.3SFTPB, TTN, SCGB1A1
2sepsis30.2PLA2G6, CSF2, CSF3, CCL4
3asthma30.2EDN1, SFTPB, SCGB1A1, CCL4, CSF2, PLA2G6
4hypertension10.6
5pulmonary function10.4
6patent ductus arteriosus10.2
7endocarditis10.2
8pancreatitis10.2
9thrombocytopenia10.2
10surfactant dysfunction10.2
11atopy10.2
12interstitial emphysema10.1
13oligohydramnios10.1OXT
14capillary leak syndrome10.1CSF2
15polyhydramnios10.1OXT
16acute chest syndrome10.1PLA2G10
17adult respiratory distress syndrome10.1PLA2G6, SFTPB
18pulmonary alveolar proteinosis10.1SFTPB, CSF2
19bronchopulmonary dysplasia10.1SCGB1A1, SFTPB
20lung benign neoplasm10.0SCGB1A1, SFTPB, OXT
21glomerulonephritis10.0SCGB1A1, CCL4, PLA2G6
22allergic asthma10.0SCGB1A1, CCL4, CSF2
23bipolar disorder10.0OXT, PLA2G6, CDH12
24idiopathic pulmonary fibrosis10.0SCGB1A1, EDN1, SFTPB, CCL4
25cyclic hematopoiesis10.0CSF2, CSF3
26severe congenital neutropenia autosomal recessive 310.0CSF3, CSF2
27leukemoid reaction10.0CSF2, CSF3
28pulmonary disease, chronic obstructive10.0TTN, SCGB1A1, SFTPB
29felty's syndrome10.0CSF2, CSF3
30severe congenital neutropenia10.0CSF3, CSF2
31pancytopenia10.0CSF3, CSF2
32atherosclerosis10.0PLA2G10, PLA2G6, EDN1, CCL4
33refractory anemia10.0CSF2, CSF3
34septic shock10.0CSF3, PLA2G6, SFTPB, OXT
35chronic myelomonocytic leukemia10.0CSF2, CSF3
36pneumonia9.9CSF3, SCGB1A1, SFTPB, CSF2
37deficiency anemia9.9CSF3, OXT, CSF2
38cork-handlers' disease9.9PLA2G6, SCGB1A1, CCL4, CSF2, EDN1, SFTPB
39non-small cell lung carcinoma9.9CCL4, SCGB1A1, CSF3, CSF2
40rheumatoid arthritis9.9CSF2, PLA2G10, PLA2G6, CCL4
41leukemia9.9CCL4, SCGB1A1, PLA2G6, CSF2, CSF3
42breast cancer9.9CSF3, CSF2, PLA2G6, OXT, SCGB1A1, CCL4

Graphical network of the top 20 diseases related to Meconium Aspiration Syndrome:



Diseases related to meconium aspiration syndrome

Symptoms for Meconium Aspiration Syndrome

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Drugs & Therapeutics for Meconium Aspiration Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Search NIH Clinical Center for Meconium Aspiration Syndrome

Genetic Tests for Meconium Aspiration Syndrome

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Anatomical Context for Meconium Aspiration Syndrome

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33MalaCards
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MalaCards organs/tissues related to Meconium Aspiration Syndrome:

33
Lung, Uterus

Animal Models for Meconium Aspiration Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Meconium Aspiration Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4CSF3, CSF2, OXT, SCGB1A1, EDN1
2MP:00053767.3PLA2G6, EDN1, SFTPB, SCGB1A1, TTN, OXT
3MP:00107687.2SLC6A11, EDN1, CSF2, PLA2G6, OXT, TTN

Publications for Meconium Aspiration Syndrome

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52PubMed
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Articles related to Meconium Aspiration Syndrome:

(show top 50)    (show all 258)
idTitleAuthorsYear
1
Lung lavage in meconium aspiration syndrome. (23662695)
2013
2
A Population-Based Study of Meconium Aspiration Syndrome in Neonates Born between 37 and 43 Weeks of Gestation. (22187569)
2012
3
Surfactant lavage therapy for meconium aspiration syndrome: a systematic review and meta-analysis. (22067375)
2012
4
Respiratory support in meconium aspiration syndrome: a practical guide. (22518190)
2012
5
Comparative effects of bronchoalveolar lavage with saline, surfactant, or perfluorocarbon in experimental meconium aspiration syndrome. (22079955)
2012
6
Use of heliox in the management of neonates with meconium aspiration syndrome. (21701217)
2011
7
Trends in obstetric practices and meconium aspiration syndrome: a population-based study. (21895951)
2011
8
Intratracheal catheter suction removes the same volume of meconium with less impact on desaturation compared with meconium aspirator in meconium aspiration syndrome. (20634007)
2010
9
Effective lavage volume of diluted surfactant improves the outcome of meconium aspiration syndrome in newborn piglets. (19287342)
2009
10
Prevention of meconium aspiration syndrome: an update and the Baylor experience. (19381312)
2009
11
Role of meconium in the reaction of airways smooth musculature in the newborn with meconium aspiration syndrome (MAS). (20002002)
2009
12
Introduction: Proceedings of the First International Conference for Meconium Aspiration Syndrome and Meconium-induced Lung Injury. (19057597)
2008
13
Extracorporeal membrane oxygenation: use in meconium aspiration syndrome. (19057615)
2008
14
Effects of a recombinant surfactant protein-C-based surfactant on lung function and the pulmonary surfactant system in a model of meconium aspiration syndrome. (16374175)
2006
15
Meconium aspiration syndrome--more than intrapartum meconium. (16135842)
2005
16
Treatment of experimental meconium aspiration syndrome with surfactant lung lavage and conventional vs. asymmetric high-frequency jet ventilation. (15334504)
2004
17
Meconium-stained amniotic fluid, meconium aspiration syndrome, and persistent pulmonary hypertension of the newborn. (15624362)
2004
18
Steroid therapy for meconium aspiration syndrome in newborn infants. (14583981)
2003
19
Meconium aspiration syndrome: is surfactant lavage the answer? (12912732)
2003
20
Racial disparity in meconium-stained amniotic fluid and meconium aspiration syndrome in the United States, 1989-2000. (14662213)
2003
21
Meconium aspiration syndrome: a role for phospholipase A2 in the pathogenesis? (11332922)
2001
22
Risk factors for meconium aspiration syndrome in infants born through thick meconium. (11146071)
2001
23
Meconium aspiration syndrome in term neonates with normal acid-base status at delivery: is it different? (11408862)
2001
24
Combined effects of high-frequency ventilation and surfactant treatment in experimental meconium aspiration syndrome. (10027019)
1999
25
Surfactant lavage for the management of severe meconium aspiration syndrome. (10393387)
1999
26
Bronchoalveolar lavage with KL4-surfactant in models of meconium aspiration syndrome. (9803452)
1998
27
Antenatal risk factors and neonatal outcome in meconium aspiration syndrome. (12348097)
1997
28
Meconium aspiration syndrome: current concepts. (12320376)
1996
29
Surfactant replacement therapy for meconium aspiration syndrome. (8545223)
1996
30
Lung lavage with a saline volume similar to functional residual capacity followed by surfactant administration in newborns with severe meconium aspiration syndrome. (8986496)
1996
31
Meconium aspiration syndrome: diagnosis and care guidelines. (7787904)
1995
32
Risk factors for meconium aspiration syndrome. (7617354)
1995
33
Meconium aspiration syndrome. (7862068)
1994
34
Surfactant therapy and high-frequency jet ventilation in the management of a piglet model of the meconium aspiration syndrome. (7816525)
1994
35
Meconium aspiration syndrome: physiological and inflammatory changes in a newborn piglet model. (8367215)
1993
36
Surfactant lavage in a piglet model of meconium aspiration syndrome. (1635826)
1992
37
Meconium aspiration syndrome: have we made a difference? (2330231)
1990
38
Meconium aspiration syndrome without evidence of fetal distress in early labor before elective cesarean delivery. (2704495)
1989
39
Extracorporeal membrane oxygenation as treatment of severe meconium aspiration syndrome. (2734633)
1989
40
Failure to prevent meconium aspiration syndrome. (3347418)
1988
41
Fatal meconium aspiration syndrome occurring despite airway management considered appropriate. (3976781)
1985
42
The relationship of thrombocytopenia to the onset of persistent pulmonary hypertension of the newborn in the meconium aspiration syndrome. (3860753)
1985
43
Experimental meconium aspiration syndrome in the preterm fetal lamb: successful treatment using the extracorporeal artificial lung. (6424302)
1983
44
Intrauterine meconium aspiration syndrome. (7439009)
1980
45
Technical aspects in the management of the meconium aspiration syndrome with extracorporeal circulation. (7411345)
1980
46
Roentgenographic findings in infants with meconium aspiration syndrome. (448867)
1979
47
Prevention of meconium aspiration syndrome in newborn infants. (660325)
1978
48
The effect of tolazoline on right-to-left shunting via a patent ductus arteriosus in meconium aspiration syndrome. (803084)
1976
49
Assisted ventilation in infants with meconium aspiration syndrome. (240148)
1975
50
Wilson-Mikity or meconium aspiration syndrome? (4695868)
1973

Variations for Meconium Aspiration Syndrome

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Expression for genes affiliated with Meconium Aspiration Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meconium Aspiration Syndrome

Search GEO for disease gene expression data for Meconium Aspiration Syndrome.

Pathways for genes affiliated with Meconium Aspiration Syndrome

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50PathCards, 53QIAGEN, 30KEGG
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Compounds for genes affiliated with Meconium Aspiration Syndrome

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45Novoseek, 24HMDB, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 1136)
idCompoundScoreTop Affiliating Genes
1popg4510.3SFTPB, PLA2G6
2romurtide4510.0CSF3, CSF2
3molgramostim4510.0CSF2, CSF3
4txb2459.9EDN1, PLA2G6, PLA2G10
5PC(P-18:1(11Z)/18:1(9Z))249.8PLA2G6, SCGB1A1, PLA2G10
6PC(P-18:1(11Z)/22:2(13Z,16Z))249.8PLA2G10, PLA2G6, SCGB1A1
7PC(P-18:1(11Z)/22:4(7Z,10Z,13Z,16Z))249.8PLA2G10, PLA2G6, SCGB1A1
8PC(P-18:1(11Z)/18:1(11Z))249.8SCGB1A1, PLA2G6, PLA2G10
9PC(P-18:0/20:5(5Z,8Z,11Z,14Z,17Z))249.8SCGB1A1, PLA2G6, PLA2G10
10PC(P-18:0/22:0)249.8PLA2G10, PLA2G6, SCGB1A1
11PC(P-18:1(11Z)/18:0)249.8PLA2G10, PLA2G6, SCGB1A1
12PC(P-18:1(11Z)/22:5(4Z,7Z,10Z,13Z,16Z))249.8PLA2G10, PLA2G6, SCGB1A1
13PC(P-18:1(9Z)/22:5(7Z,10Z,13Z,16Z,19Z))249.8PLA2G10, PLA2G6, SCGB1A1
14PC(P-18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))249.8PLA2G10, PLA2G6, SCGB1A1
15PC(P-18:1(9Z)/24:0)249.8PLA2G10, PLA2G6, SCGB1A1
16PC(P-18:1(9Z)/18:4(6Z,9Z,12Z,15Z))249.7SCGB1A1, PLA2G6, PLA2G10
17PC(P-18:1(9Z)/18:3(6Z,9Z,12Z))249.7PLA2G10, PLA2G6, SCGB1A1
18PC(P-18:1(9Z)/18:3(9Z,12Z,15Z))249.7PLA2G10, PLA2G6, SCGB1A1
19PC(P-16:0/15:0)249.7SCGB1A1, PLA2G6, PLA2G10
20PC(P-16:0/20:3(5Z,8Z,11Z))249.7PLA2G10, PLA2G6, SCGB1A1
21PC(P-16:0/20:3(8Z,11Z,14Z))249.7PLA2G10, PLA2G6, SCGB1A1
22PC(P-16:0/20:4(5Z,8Z,11Z,14Z))249.7PLA2G10, PLA2G6, SCGB1A1
23PC(O-16:0/18:2(9Z,12Z))249.6PLA2G6, SCGB1A1, PLA2G10
24PC(P-16:0/14:0)249.6PLA2G10, PLA2G6, SCGB1A1
25PC(P-16:0/14:1(9Z))249.6PLA2G10, PLA2G6, SCGB1A1
26fluoride459.6CSF2, OXT, PLA2G6
27PC(P-18:0/16:1(9Z))249.6PLA2G6, SCGB1A1, PLA2G10
28PC(P-18:0/18:0)249.5PLA2G10, PLA2G6, SCGB1A1
29PC(P-18:0/20:4(8Z,11Z,14Z,17Z))249.4PLA2G10, PLA2G6, SCGB1A1
30PC(P-18:0/15:0)249.4PLA2G10, PLA2G6, SCGB1A1
31prostaglandin f2alpha459.4EDN1, SFTPB, OXT, PLA2G6
32PC(P-18:0/16:0)249.3SCGB1A1, PLA2G10, PLA2G6
33nifedipine45 29 51 1112.3CSF2, EDN1, OXT, PLA2G6
34thapsigargin45 6110.3EDN1, OXT, PLA2G6, CSF2
35amphotericin b459.2CCL4, CSF2, CSF3
36PC(P-16:0/20:4(8Z,11Z,14Z,17Z))249.1PLA2G10, PLA2G6, SCGB1A1
37sb 20358045 6110.1CSF2, PLA2G6, CCL4, EDN1
38(+-)-pgf2-alpha458.9PLA2G6, OXT, CCL4, SFTPB
39valine458.9TTN, OXT, CSF3, CSF2
40endotoxin458.9CCL4, SCGB1A1, CSF2, CSF3
41arachidonic acid45 29 24 1111.6PLA2G6, PLA2G10, EDN1, SCGB1A1, CSF2, OXT
42cyclosporin a45 29 6110.6CCL4, CSF3, CSF2, EDN1, PLA2G6
43dexamethasone45 51 29 1111.6CSF2, PLA2G6, SFTPB, CSF3, CCL4
44cycloheximide458.3EDN1, SFTPB, CCL4, PLA2G6, CSF2, CSF3
45creatinine458.1PLA2G6, OXT, TTN, CCL4, SCGB1A1, EDN1
46cysteine458.0CCL4, CSF2, SFTPB, PLA2G6, OXT, TTN
47vegf458.0CSF3, EDN1, SFTPB, OXT, CCL4, CSF2
48retinoic acid45 249.0SFTPB, OXT, CCL4, CSF3, CSF2, PLA2G6
49pge2457.8SFTPB, EDN1, OXT, PLA2G6, CCL4, PLA2G10
50calcium45 51 24 119.9EDN1, SFTPB, SCGB1A1, TTN, OXT, CCL4

GO Terms for genes affiliated with Meconium Aspiration Syndrome

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16Gene Ontology
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Cellular components related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5EDN1, TTN, OXT, CCL4, PLA2G10, CSF2
2extracellular spaceGO:0056157.0EDN1, SFTPB, SCGB1A1, OXT, CCL4, CSF2

Biological processes related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1epithelial fluid transportGO:04204510.0CSF2, EDN1
2positive regulation of arachidonic acid secretionGO:0902389.9PLA2G10, PLA2G6
3phosphatidylethanolamine acyl-chain remodelingGO:0361529.8PLA2G10, PLA2G6
4positive regulation of macrophage derived foam cell differentiationGO:0107449.6CSF2, PLA2G10
5positive regulation of renal sodium excretionGO:0358159.6OXT, EDN1
6positive regulation of prostaglandin secretionGO:0323089.6PLA2G10, OXT
7positive regulation of cytosolic calcium ion concentrationGO:0072049.3EDN1, OXT, PLA2G6
8regulation of sensory perception of painGO:0519309.3OXT, EDN1

Molecular functions related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.8PLA2G10, PLA2G6
2cytokine activityGO:0051258.2CSF3, CSF2, CCL4, EDN1

Products for genes affiliated with Meconium Aspiration Syndrome

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Sources for Meconium Aspiration Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet