MAS
MCID: MCN007

Meconium Aspiration Syndrome malady

Summaries for Meconium Aspiration Syndrome

Sources:
30NIH Rare Diseases, 44Wikipedia, 22MalaCards
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NIH Rare Diseases: Meconium aspiration syndrome is a serious condition in which a newborn breathes a mixture of meconium and amniotic fluid into the lungs around the time of delivery. This can cause breathing difficulties due to swelling (inflammation) in the baby's lungs after birth. Treatment may include suctioning the newborn's mouth as soon as the head emerges during delivery, deep suctioning of the windpipe, antibiotics to treat infection, oxygen to keep blood levels normal, and radiant heat to maintain body temperature. In severe cases, the baby may need assistance breathing (ventilator).30

MalaCards: Meconium Aspiration Syndrome, also known as neonatal aspiration of meconium (disorder), is related to systemic lupus erythematosus and lupus erythematosus. An important gene associated with Meconium Aspiration Syndrome is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are Cytokine production by Th17 cells in CF and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds romurtide and molgramostim have been mentioned in the context of this disorder. Affiliated tissues include lung and uterus.

Wikipedia: Meconium aspiration syndrome (MAS, alternatively \"Neonatal aspiration of meconium\") is a medical...44 more...

Aliases & Descriptions for Meconium Aspiration Syndrome

Sources:
6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 24MeSH, 27NCIt
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Aliases & Descriptions:

meconium aspiration syndrome 6 30 8 32 43
neonatal aspiration of meconium (disorder) 6
neonatal aspiration, unspecified 43
meconium aspiration 6
mas 30

Related Diseases for Meconium Aspiration Syndrome

Sources:
13GeneCards, 14GeneDecks
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Diseases related to meconium aspiration syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 257)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus27.9CSF3, CSF2, CCL4, SCGB1A1
2lupus erythematosus27.9CSF3, CSF2, CCL4, SCGB1A1
3asthma26.0CSF3, CSF2, CCL4, SCGB1A1
4cerebritis25.7CCL4, CSF2, CSF3, SLC6A11
5dermatitis25.3CSF3, CSF2, CCL4
6vasculitis25.1CSF3, CCL4, SCGB1A1
7rheumatoid arthritis25.1CSF3, CSF2, CCL4, SCGB1A1
8plasmodium falciparum malaria25.0CCL4, CSF2
9arthritis24.9CSF3, CSF2, CCL4, SCGB1A1
10sepsis24.6CCL4, CSF2, CSF3
11hematopoiesis24.4CCL4, CSF2, CSF3
12pneumonia23.8CSF3, CSF2, CCL4, SCGB1A1
13breast carcinoma23.8CSF3, CSF2, CCL4, SCGB1A1
14blindness23.4CCL4, CSF2, CSF3
15acute interstitial pneumonia12.9CSF3, SCGB1A1
16pulmonary edema12.8SCGB1A1, CSF3
17castleman's disease12.7CCL4, CSF3
18crescentic glomerulonephritis12.7SCGB1A1, CCL4
19myelokathexis12.6CSF3, CSF2
20cyclic hematopoiesis12.6CSF3, CSF2
21leukemoid reaction12.6CSF2, CSF3
22chronic neutrophilic leukemia12.6CSF3, CSF2
23granulocytopenia12.6CSF3, CSF2
24felty's syndrome12.6CSF3, CSF2
25hypersplenism12.6CSF3, CSF2
26capillary leak syndrome12.6CSF2, CSF3
27dyserythropoietic anemia with thrombocytopenia12.6CSF2, CSF3
28idiopathic pulmonary fibrosis12.6SCGB1A1, CCL4
29chronic myelomonocytic leukemia12.6CSF2, CSF3
30skin carcinoma12.6CSF2, CSF3
31large cell carcinoma12.6CSF2, CSF3
32factor vii deficiency12.5CSF3, CSF2
33large granular lymphocyte leukemia12.5CSF3, CSF2
34severe congenital neutropenia12.5CSF3, CSF2
35pancytopenia12.5CSF3, CSF2
36aplastic anemia12.5CSF2, CSF3
37graft versus host disease12.5CSF3, CSF2
38hemolytic-uremic syndrome12.5CSF3, CCL4
39chronic granulomatous disease12.4CSF2, CSF3
40eosinophilic pneumonia12.4CCL4, CSF2
41retinopathy of prematurity12.4CSF3, CSF2
42thrombocytosis12.4CSF2, CSF3
43mycobacterial infection12.4CSF2, CCL4
44myeloproliferative disorder12.4CSF2, CSF3
45hairy cell leukemia12.3CSF2, CSF3
46childhood leukemia12.2CSF3, CSF2
47respiratory failure12.2SCGB1A1, CSF2, CSF3
48aspergillosis12.1CSF3, CSF2
49peripheral t-cell lymphoma12.1CSF2, CSF3
50purpura12.1SCGB1A1, CSF2, CSF3

Graphical network of the top 20 diseases related to meconium aspiration syndrome:



Graphical network of diseases related to meconium aspiration syndrome

Clinical Features for Meconium Aspiration Syndrome

Drugs & Therapeutics for Meconium Aspiration Syndrome

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for meconium aspiration syndrome

Drug clinical trials:

Search ClinicalTrials for meconium aspiration syndrome

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Search CenterWatch for meconium aspiration syndrome

Genetic Tests for Meconium Aspiration Syndrome

Anatomical Context for Meconium Aspiration Syndrome

Sources:
22MalaCards
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MalaCards organs/tissues related to meconium aspiration syndrome:

22
Lung, Uterus

Phenotypes for genes affiliated with Meconium Aspiration Syndrome

Publications for genes affiliated with Meconium Aspiration Syndrome

Sources:
35PubMed
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Articles related to meconium aspiration syndrome:

idTitleAuthorsYearAffiliating Genes
1Serum cytokine and chemokine profiles in neonates with meconium aspiration syndrome. (18346989)Okazaki K.... Kimura H.2008CSF2, CSF3, CCL4
2CC10 reduces inflammation in meconium aspiration syndrome in newborn piglets. (17957145)Angert R.M.... Davis J.M.2007SCGB1A1

Expression for genes affiliated with Meconium Aspiration Syndrome

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Meconium Aspiration Syndrome

Pathways for genes affiliated with Meconium Aspiration Syndrome

Sources:
41Thomson Reuters, 37R&D Systems, 20KEGG, 36QIAGEN
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Compounds for genes affiliated with Meconium Aspiration Syndrome

Sources:
32Novoseek , 9DrugBank, 34PharmGKB, 18HMDB, 42Tocris Bioscience
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Compounds related to meconium aspiration syndrome according to GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1romurtide32 9.6CSF3, CSF2
2molgramostim32 9.6CSF2, CSF3
3pegfilgrastim32 9 9 11.6CSF2, CSF3
4mesna32 9.6CSF2, CSF3
5thiotepa32 34 9 9 12.6CSF2, CSF3
6ara-ctp32 9.6CSF3, CSF2
7ccl332 9.6CSF3, CCL4
8mafosfamide32 9.6CSF3, CSF2
94-hydroperoxycyclophosphamide32 9.5CSF2, CSF3
10pixy32132 9.5CSF3, CSF2
11amifostine32 9 9 11.5CSF2, CSF3
12idarubicin32 9 9 11.5CSF3, CSF2
13filgrastim32 9 9 11.5CSF2, CSF3
14dacarbazine32 9 9 11.5CSF2, CSF3
15bcnu32 9.5CSF3, CSF2
16gm-csf32 9.5CSF2, CSF3
17ifosfamide32 9 9 11.5CSF3, CSF2
18leucovorin32 34 9 9 12.5CSF2, CSF3
19mitoxantrone32 9 9 11.5CSF3, CSF2
20methylcellulose32 9.5CSF2, CSF3
21fludarabine32 9 9 11.4CSF2, CSF3
22mip 1alpha32 9.4CCL4, CSF2
23anti-fungal32 9.4CSF2, CSF3
24larc32 9.4CSF2, CCL4
25mdms32 9.4CSF2, CCL4
26ribavirin32 34 9 9 12.4CSF2, CSF3
27groalpha32 9.4CCL4, CSF2
28n-formylmethionyl-leucylphenylalanine32 9.4CSF3, CSF2
29il 1032 9.4CSF2, CCL4
30cytochalasin b32 9.4CSF2, CCL4
31tarc32 9.3CCL4, CSF2
32melphalan32 9 9 11.3CSF2, CSF3
33ganciclovir32 9 9 11.3CSF2, CSF3
34ivig32 9.3CCL4, CSF2
35rituximab32 34 9 9 12.2CSF3, CSF2
36ibuprofen32 9 18 9 12.2CSF2, CCL4
37daunorubicin32 9 9 11.2CSF2, CSF3
38bleomycin32 9 9 11.1CSF2, CSF3
39gp 13032 9.1CSF3, CSF2, SCGB1A1
40carboplatin32 34 9 9 12.0CSF3, CSF2
41amphotericin b32 9.0CCL4, CSF2, CSF3
42rantes32 8.9CCL4, CSF2, CSF3
43cyclosporin a32 42 9.9CCL4, CSF2, CSF3
44zidovudine32 9 9 10.8CSF2, CSF3
45superoxide32 18 9.8CSF3, CSF2, CCL4
46cycloheximide32 8.5CCL4, CSF2, CSF3
47endotoxin32 8.5SCGB1A1, CCL4, CSF2, CSF3

GO Terms for genes affiliated with Meconium Aspiration Syndrome

Sources:
12Gene Ontology
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Biological processes related to meconium aspiration syndrome according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069558.5CCL4, CSF2, CSF3

Molecular functions related to meconium aspiration syndrome according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.5CCL4, CSF2, CSF3

Sources for Meconium Aspiration Syndrome

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS