MAS
MCID: MCN007
MIFTS: 56

Meconium Aspiration Syndrome (MAS) malady

Rare diseases, Fetal diseases, Respiratory diseases categories

Summaries for Meconium Aspiration Syndrome

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NIH Rare Diseases:42 Meconium aspiration syndrome is a serious condition in which a newborn breathes a mixture of meconium and amniotic fluid into the lungs around the time of delivery. this can cause breathing difficulties due to swelling (inflammation) in the baby's lungs after birth. treatment may include suctioning the newborn's mouth as soon as the head emerges during delivery, deep suctioning of the windpipe, antibiotics to treat infection, oxygen to keep blood levels normal, and radiant heat to maintain body temperature. in severe cases, the baby may need assistance breathing (ventilator). last updated: 1/12/2012

MalaCards based summary: Meconium Aspiration Syndrome, also known as neonatal aspiration, unspecified, is related to respiratory failure and sepsis. An important gene associated with Meconium Aspiration Syndrome is SFTPB (surfactant protein B), and among its related pathways are PEDF Induced Signaling and PAK Pathway. The compounds popg and romurtide have been mentioned in the context of this disorder. Affiliated tissues include lung and uterus, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Wikipedia:64 Meconium aspiration syndrome (MAS, alternatively \"Neonatal aspiration of meconium\") is a medical... more...

Aliases & Classifications for Meconium Aspiration Syndrome

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Sources:
9Disease Ontology, 42NIH Rare Diseases, 11DISEASES, 44Novoseek, 48Orphanet, 61UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet, 26ICD10
See all sources

Meconium Aspiration Syndrome, Aliases & Descriptions:

Name: Meconium Aspiration Syndrome 9 42 11 44 48 61
Neonatal Aspiration, Unspecified 61
Neonatal Aspiration of Meconium 9
 
Meconium Aspiration 9
Mas 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
meconium aspiration syndrome:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


External Ids:

Disease Ontology9 DOID:11049
MeSH34 D008471
NCIt39 C87093
MESH via Orphanet35 D008471
ICD10 via Orphanet27 P24.0
UMLS via Orphanet62 C0025048

Related Diseases for Meconium Aspiration Syndrome

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Diseases related to Meconium Aspiration Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1respiratory failure30.4SFTPB, TTN, SCGB1A1
2sepsis30.0PLA2G6, CSF2, CSF3, CCL4
3asthma29.9EDN1, SFTPB, SCGB1A1, CCL4, CSF2, PLA2G6
4hypertension10.5
5pulmonary hypertension10.5
6pulmonary function10.4
7oligohydramnios10.4OXT
8capillary leak syndrome10.4CSF2
9polyhydramnios10.4OXT
10acute chest syndrome10.3PLA2G10
11adult respiratory distress syndrome10.3PLA2G6, SFTPB
12pulmonary alveolar proteinosis10.3SFTPB, CSF2
13bronchopulmonary dysplasia10.2SCGB1A1, SFTPB
14patent ductus arteriosus10.2
15endocarditis10.2
16pancreatitis10.2
17surfactant dysfunction10.2
18atopy10.2
19lung benign neoplasm10.2SCGB1A1, SFTPB, OXT
20glomerulonephritis10.2SCGB1A1, CCL4, PLA2G6
21interstitial emphysema10.1
22aspiration pneumonitis10.1
23allergic asthma10.1SCGB1A1, CCL4, CSF2
24bipolar disorder10.1OXT, PLA2G6, CDH12
25idiopathic pulmonary fibrosis10.1SCGB1A1, EDN1, SFTPB, CCL4
26cyclic hematopoiesis10.1CSF2, CSF3
27severe congenital neutropenia autosomal recessive 310.1CSF3, CSF2
28leukemoid reaction10.1CSF2, CSF3
29chronic obstructive pulmonary disease10.1TTN, SCGB1A1, SFTPB
30felty's syndrome10.1CSF2, CSF3
31severe congenital neutropenia10.0CSF3, CSF2
32pancytopenia9.9CSF3, CSF2
33atherosclerosis9.9PLA2G10, PLA2G6, EDN1, CCL4
34refractory anemia9.9CSF2, CSF3
35septic shock9.9CSF3, PLA2G6, SFTPB, OXT
36pdgfrb-associated chronic eosinophilic leukemia9.9CSF2, CSF3
37pneumonia9.8CSF3, SCGB1A1, SFTPB, CSF2
38deficiency anemia9.8CSF3, OXT, CSF2
39cork-handlers' disease9.8PLA2G6, SCGB1A1, CCL4, CSF2, EDN1, SFTPB
40non-small cell lung carcinoma9.7CCL4, SCGB1A1, CSF3, CSF2
41rheumatoid arthritis9.6CSF2, PLA2G10, PLA2G6, CCL4
42leukemia9.6CCL4, SCGB1A1, PLA2G6, CSF2, CSF3
43breast cancer9.5CSF3, CSF2, PLA2G6, OXT, SCGB1A1, CCL4

Graphical network of the top 20 diseases related to Meconium Aspiration Syndrome:



Diseases related to meconium aspiration syndrome

Symptoms for Meconium Aspiration Syndrome

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Drugs & Therapeutics for Meconium Aspiration Syndrome

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Drug clinical trials:

Search ClinicalTrials for Meconium Aspiration Syndrome

Search NIH Clinical Center for Meconium Aspiration Syndrome

Genetic Tests for Meconium Aspiration Syndrome

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Anatomical Context for Meconium Aspiration Syndrome

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MalaCards organs/tissues related to Meconium Aspiration Syndrome:

32
Lung, Uterus

Animal Models for Meconium Aspiration Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Meconium Aspiration Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4CSF3, CSF2, OXT, SCGB1A1, EDN1
2MP:00053767.3CSF2, EDN1, SFTPB, SCGB1A1, TTN, OXT
3MP:00107687.2EDN1, SFTPB, SCGB1A1, TTN, OXT, PLA2G6

Publications for Meconium Aspiration Syndrome

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Articles related to Meconium Aspiration Syndrome:

(show top 50)    (show all 263)
idTitleAuthorsYear
1
Lung lavage in meconium aspiration syndrome. (23662695)
2013
2
A Population-Based Study of Meconium Aspiration Syndrome in Neonates Born between 37 and 43 Weeks of Gestation. (22187569)
2012
3
Surfactant lavage therapy for meconium aspiration syndrome: a systematic review and meta-analysis. (22067375)
2012
4
Respiratory support in meconium aspiration syndrome: a practical guide. (22518190)
2012
5
Comparative effects of bronchoalveolar lavage with saline, surfactant, or perfluorocarbon in experimental meconium aspiration syndrome. (22079955)
2012
6
Use of heliox in the management of neonates with meconium aspiration syndrome. (21701217)
2011
7
Trends in obstetric practices and meconium aspiration syndrome: a population-based study. (21895951)
2011
8
Intratracheal catheter suction removes the same volume of meconium with less impact on desaturation compared with meconium aspirator in meconium aspiration syndrome. (20634007)
2010
9
Effective lavage volume of diluted surfactant improves the outcome of meconium aspiration syndrome in newborn piglets. (19287342)
2009
10
Prevention of meconium aspiration syndrome: an update and the Baylor experience. (19381312)
2009
11
Role of meconium in the reaction of airways smooth musculature in the newborn with meconium aspiration syndrome (MAS). (20002002)
2009
12
Introduction: Proceedings of the First International Conference for Meconium Aspiration Syndrome and Meconium-induced Lung Injury. (19057597)
2008
13
Extracorporeal membrane oxygenation: use in meconium aspiration syndrome. (19057615)
2008
14
Combination of budesonide and aminophylline diminished acute lung injury in animal model of meconium aspiration syndrome. (19218670)
2008
15
Effects of a recombinant surfactant protein-C-based surfactant on lung function and the pulmonary surfactant system in a model of meconium aspiration syndrome. (16374175)
2006
16
Meconium aspiration syndrome--more than intrapartum meconium. (16135842)
2005
17
Treatment of experimental meconium aspiration syndrome with surfactant lung lavage and conventional vs. asymmetric high-frequency jet ventilation. (15334504)
2004
18
Meconium-stained amniotic fluid, meconium aspiration syndrome, and persistent pulmonary hypertension of the newborn. (15624362)
2004
19
Steroid therapy for meconium aspiration syndrome in newborn infants. (14583981)
2003
20
Meconium aspiration syndrome: is surfactant lavage the answer? (12912732)
2003
21
Racial disparity in meconium-stained amniotic fluid and meconium aspiration syndrome in the United States, 1989-2000. (14662213)
2003
22
Meconium aspiration syndrome: a role for phospholipase A2 in the pathogenesis? (11332922)
2001
23
Risk factors for meconium aspiration syndrome in infants born through thick meconium. (11146071)
2001
24
Meconium aspiration syndrome in term neonates with normal acid-base status at delivery: is it different? (11408862)
2001
25
Combined effects of high-frequency ventilation and surfactant treatment in experimental meconium aspiration syndrome. (10027019)
1999
26
Surfactant lavage for the management of severe meconium aspiration syndrome. (10393387)
1999
27
Bronchoalveolar lavage with KL4-surfactant in models of meconium aspiration syndrome. (9803452)
1998
28
Antenatal risk factors and neonatal outcome in meconium aspiration syndrome. (12348097)
1997
29
Meconium aspiration syndrome: current concepts. (12320376)
1996
30
Surfactant replacement therapy for meconium aspiration syndrome. (8545223)
1996
31
Lung lavage with a saline volume similar to functional residual capacity followed by surfactant administration in newborns with severe meconium aspiration syndrome. (8986496)
1996
32
Meconium aspiration syndrome: diagnosis and care guidelines. (7787904)
1995
33
Risk factors for meconium aspiration syndrome. (7617354)
1995
34
Meconium aspiration syndrome. (7862068)
1994
35
Surfactant therapy and high-frequency jet ventilation in the management of a piglet model of the meconium aspiration syndrome. (7816525)
1994
36
Meconium aspiration syndrome: physiological and inflammatory changes in a newborn piglet model. (8367215)
1993
37
Surfactant lavage in a piglet model of meconium aspiration syndrome. (1635826)
1992
38
Meconium aspiration syndrome: have we made a difference? (2330231)
1990
39
Meconium aspiration syndrome without evidence of fetal distress in early labor before elective cesarean delivery. (2704495)
1989
40
Extracorporeal membrane oxygenation as treatment of severe meconium aspiration syndrome. (2734633)
1989
41
Failure to prevent meconium aspiration syndrome. (3347418)
1988
42
Fatal meconium aspiration syndrome occurring despite airway management considered appropriate. (3976781)
1985
43
Experimental meconium aspiration syndrome in the preterm fetal lamb: successful treatment using the extracorporeal artificial lung. (6424302)
1983
44
Intrauterine meconium aspiration syndrome. (7439009)
1980
45
Technical aspects in the management of the meconium aspiration syndrome with extracorporeal circulation. (7411345)
1980
46
Roentgenographic findings in infants with meconium aspiration syndrome. (448867)
1979
47
Prevention of meconium aspiration syndrome in newborn infants. (660325)
1978
48
The effect of tolazoline on right-to-left shunting via a patent ductus arteriosus in meconium aspiration syndrome. (803084)
1976
49
Assisted ventilation in infants with meconium aspiration syndrome. (240148)
1975
50
Wilson-Mikity or meconium aspiration syndrome? (4695868)
1973

Variations for Meconium Aspiration Syndrome

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Expression for genes affiliated with Meconium Aspiration Syndrome

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Expression patterns in normal tissues for genes affiliated with Meconium Aspiration Syndrome

Search GEO for disease gene expression data for Meconium Aspiration Syndrome.

Pathways for genes affiliated with Meconium Aspiration Syndrome

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Compounds for genes affiliated with Meconium Aspiration Syndrome

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Compounds related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 1136)
idCompoundScoreTop Affiliating Genes
1popg4410.3SFTPB, PLA2G6
2romurtide4410.0CSF3, CSF2
3molgramostim4410.0CSF2, CSF3
4txb2449.9EDN1, PLA2G6, PLA2G10
5PC(P-18:1(11Z)/18:0)259.8PLA2G6, SCGB1A1, PLA2G10
6PC(P-18:1(11Z)/22:0)259.8PLA2G10, PLA2G6, SCGB1A1
7PC(P-18:1(11Z)/22:1(13Z))259.8PLA2G10, PLA2G6, SCGB1A1
8PC(P-18:1(11Z)/16:1(9Z))259.8SCGB1A1, PLA2G6, PLA2G10
9PC(P-18:0/20:4(5Z,8Z,11Z,14Z))259.8SCGB1A1, PLA2G6, PLA2G10
10PC(P-18:0/20:4(8Z,11Z,14Z,17Z))259.8PLA2G10, PLA2G6, SCGB1A1
11PC(P-18:1(11Z)/16:0)259.8PLA2G10, PLA2G6, SCGB1A1
12PC(P-18:1(11Z)/22:2(13Z,16Z))259.8PLA2G10, PLA2G6, SCGB1A1
13PC(P-18:1(9Z)/22:4(7Z,10Z,13Z,16Z))259.8PLA2G10, PLA2G6, SCGB1A1
14PC(P-18:1(9Z)/22:5(4Z,7Z,10Z,13Z,16Z))259.8PLA2G10, PLA2G6, SCGB1A1
15PC(P-18:1(9Z)/22:5(7Z,10Z,13Z,16Z,19Z))259.8PLA2G10, PLA2G6, SCGB1A1
16PC(P-18:1(9Z)/18:3(6Z,9Z,12Z))259.7SCGB1A1, PLA2G6, PLA2G10
17PC(P-18:1(9Z)/18:1(9Z))259.7PLA2G10, PLA2G6, SCGB1A1
18PC(P-18:1(9Z)/18:2(9Z,12Z))259.7PLA2G10, PLA2G6, SCGB1A1
19PC(P-16:0/14:0)259.7SCGB1A1, PLA2G6, PLA2G10
20PC(P-16:0/20:1(11Z))259.7PLA2G10, PLA2G6, SCGB1A1
21PC(P-16:0/20:2(11Z,14Z))259.7PLA2G10, PLA2G6, SCGB1A1
22PC(P-16:0/20:3(5Z,8Z,11Z))259.7PLA2G10, PLA2G6, SCGB1A1
23PC(20:3(8Z,11Z,14Z)/20:1(11Z))259.6PLA2G6, SCGB1A1, PLA2G10
24PC(dm18:1(11Z)/20:4(8Z,11Z,14Z,17Z))259.6PLA2G10, PLA2G6, SCGB1A1
25PC(O-16:0/18:2(9Z,12Z))259.6PLA2G10, PLA2G6, SCGB1A1
26fluoride449.6CSF2, OXT, PLA2G6
27PC(P-18:0/15:0)259.6PLA2G6, SCGB1A1, PLA2G10
28PC(P-18:0/16:0)259.5PLA2G10, PLA2G6, SCGB1A1
29PC(P-18:0/20:3(8Z,11Z,14Z))259.4PLA2G10, PLA2G6, SCGB1A1
30PC(P-18:0/14:0)259.4PLA2G10, PLA2G6, SCGB1A1
31prostaglandin f2alpha449.4EDN1, SFTPB, OXT, PLA2G6
32PC(P-18:0/14:1(9Z))259.3SCGB1A1, PLA2G10, PLA2G6
33nifedipine44 29 50 1212.3CSF2, EDN1, OXT, PLA2G6
34thapsigargin44 6010.3EDN1, OXT, PLA2G6, CSF2
35amphotericin b449.2CCL4, CSF2, CSF3
36PC(P-16:0/20:3(8Z,11Z,14Z))259.1PLA2G10, PLA2G6, SCGB1A1
37sb 20358044 6010.1CSF2, PLA2G6, CCL4, EDN1
38(+-)-pgf2-alpha448.9PLA2G6, OXT, CCL4, SFTPB
39valine448.9TTN, OXT, CSF3, CSF2
40endotoxin448.9CCL4, SCGB1A1, CSF2, CSF3
41arachidonic acid44 29 25 1211.6PLA2G6, PLA2G10, EDN1, SCGB1A1, CSF2, OXT
42cyclosporin a44 29 6010.6CCL4, CSF3, CSF2, EDN1, PLA2G6
43dexamethasone44 50 29 1211.6CSF2, PLA2G6, SFTPB, CSF3, CCL4
44cycloheximide448.3EDN1, SFTPB, CCL4, PLA2G6, CSF2, CSF3
45creatinine448.1PLA2G6, OXT, TTN, CCL4, SCGB1A1, EDN1
46cysteine448.0CCL4, CSF2, SFTPB, PLA2G6, OXT, TTN
47vegf448.0CSF3, EDN1, SFTPB, OXT, CCL4, CSF2
48retinoic acid44 259.0SFTPB, OXT, CCL4, CSF3, CSF2, PLA2G6
49pge2447.8SFTPB, EDN1, OXT, PLA2G6, CCL4, PLA2G10
50calcium44 50 25 129.9EDN1, SFTPB, SCGB1A1, TTN, OXT, CCL4

GO Terms for genes affiliated with Meconium Aspiration Syndrome

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Cellular components related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5CSF2, PLA2G10, CCL4, OXT, TTN, EDN1
2extracellular spaceGO:0056157.0CSF3, EDN1, SFTPB, SCGB1A1, OXT, CCL4

Biological processes related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1epithelial fluid transportGO:04204510.0CSF2, EDN1
2positive regulation of arachidonic acid secretionGO:0902389.9PLA2G10, PLA2G6
3phosphatidylethanolamine acyl-chain remodelingGO:0361529.8PLA2G10, PLA2G6
4positive regulation of macrophage derived foam cell differentiationGO:0107449.6CSF2, PLA2G10
5positive regulation of renal sodium excretionGO:0358159.6OXT, EDN1
6positive regulation of prostaglandin secretionGO:0323089.6PLA2G10, OXT
7positive regulation of cytosolic calcium ion concentrationGO:0072049.3EDN1, OXT, PLA2G6
8regulation of sensory perception of painGO:0519309.3OXT, EDN1

Molecular functions related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.8PLA2G10, PLA2G6
2cytokine activityGO:0051258.2CSF3, CSF2, CCL4, EDN1

Products for genes affiliated with Meconium Aspiration Syndrome

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Sources for Meconium Aspiration Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet