MAS
MCID: MCN007
MIFTS: 52

Meconium Aspiration Syndrome (MAS) malady

Fetal diseases, Respiratory diseases categories

Summaries for Meconium Aspiration Syndrome

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Meconium aspiration syndrome is a serious condition in which a newborn breathes a mixture of meconium and amniotic fluid into the lungs around the time of delivery. this can cause breathing difficulties due to swelling (inflammation) in the baby's lungs after birth. treatment may include suctioning the newborn's mouth as soon as the head emerges during delivery, deep suctioning of the windpipe, antibiotics to treat infection, oxygen to keep blood levels normal, and radiant heat to maintain body temperature. in severe cases, the baby may need assistance breathing (ventilator). last updated: 1/12/2012

MalaCards: Meconium Aspiration Syndrome, also known as neonatal aspiration, unspecified, is related to hypertension and dermatitis. An important gene associated with Meconium Aspiration Syndrome is SFTPB (surfactant protein B), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and melatonin degradation II. The compounds valine and popg have been mentioned in the context of this disorder. Affiliated tissues include lung and uterus.

Wikipedia:63 Meconium aspiration syndrome (MAS, alternatively \"Neonatal aspiration of meconium\") is a medical... more...

Aliases & Classifications for Meconium Aspiration Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
meconium aspiration syndrome:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

meconium aspiration syndrome 8 42 10 44 48 60
neonatal aspiration, unspecified 60
neonatal aspiration of meconium 8
meconium aspiration 8
mas 42


External Ids:

Disease Ontology8 DOID:11049
MeSH34 D008471
NCIt39 C87093
MESH via Orphanet35 D008471
ICD10 via Orphanet26 P24.0
SNOMED-CT via Orphanet57 206292002
UMLS via Orphanet61 C0025048

Related Diseases for Meconium Aspiration Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Meconium Aspiration Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.8EDN1
2dermatitis30.2PLA2G6, CSF2
3pancreatitis30.2PLA2G6
4respiratory failure30.2SFTPB, SCGB1A1, TTN
5asthma30.2CCL4, SFTPB, CSF2, SCGB1A1, EDN1, PLA2G6
6malaria29.8PLA2G6
7adenocarcinoma29.8SFTPB, SCGB1A1
8astrocytoma29.7PLA2G6, CCL4
9mccune albright syndrome10.3
10migraine with aura10.2
11edwards syndrome10.2
12patent ductus arteriosus10.2
13endocarditis10.2
14thrombocytopenia10.2
15migraine10.1
16interstitial emphysema10.1
17aspiration pneumonitis10.1
18stroke, ischemic10.0
19atopic dermatitis10.0
20cerebritis10.0
21infertility10.0
22diffuse large b-cell lymphoma10.0
23contact dermatitis10.0
24congenital diaphragmatic hernia10.0SFTPB
25meningioma10.0PLA2G6
26rhinitis10.0SCGB1A1
27cor pulmonale10.0EDN1
28peritonitis10.0PLA2G6
29disseminated intravascular coagulation10.0OXT
30meningitis10.0CCL4
31hepatopulmonary syndrome10.0EDN1
32human immunodeficiency virus infectious disease10.0CCL4
33glaucoma10.0EDN1
34capillary leak syndrome10.0CSF2
35sickle cell disease10.0EDN1, PLA2G10
36bronchopulmonary dysplasia10.0SCGB1A1, SFTPB
37pulmonary fibrosis10.0EDN1, CCL4
38sarcoidosis10.0SCGB1A1, CCL4
39pulmonary alveolar proteinosis10.0CSF2, SFTPB
40acute chest syndrome10.0PLA2G10
41cystic fibrosis10.0SFTPB, SCGB1A1, PLA2G6
42adult respiratory distress syndrome10.0SFTPB, PLA2G6
43cervical cancer10.0SMOX
44neuropathy10.0TTN
45newborn respiratory distress syndrome10.0TTN
46glomerulonephritis10.0CCL4, SCGB1A1, PLA2G6
47arthritis10.0CCL4, CSF2, PLA2G6
48lung benign neoplasm10.0SFTPB, SCGB1A1, OXT
49lung cancer10.0CSF2, CSF3
50severe congenital neutropenia autosomal recessive 310.0CSF2, CSF3

Graphical network of the top 20 diseases related to Meconium Aspiration Syndrome:



Diseases related to meconium aspiration syndrome

Clinical Features for Meconium Aspiration Syndrome

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Drugs & Therapeutics for Meconium Aspiration Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Meconium Aspiration Syndrome

Genetic Tests for Meconium Aspiration Syndrome

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Anatomical Context for Meconium Aspiration Syndrome

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32MalaCards
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MalaCards organs/tissues related to Meconium Aspiration Syndrome:

32
Lung, Uterus

Animal Models for Meconium Aspiration Syndrome or affiliated genes

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Publications for Meconium Aspiration Syndrome

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50PubMed
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Articles related to Meconium Aspiration Syndrome:

(show top 50)    (show all 260)
idTitleAuthorsYear
1
Anti-inflammatory treatment of meconium aspiration syndrome: benefits and risks. (23466955)
2013
2
Spectrophotometric analysis in umbilical cords of infants with meconium aspiration syndrome. (23743814)
2013
3
Fluid recovery during lung lavage in meconium aspiration syndrome. (23194445)
2013
4
Respiratory distress including meconium aspiration syndrome in vigorous neonates born through meconium stained amniotic fluid: incidence, onset, severity and predictors at birth. (23188709)
2013
5
Meconium Aspiration Syndrome - a 21-years' Experience from a Tertiary Care Center and Analysis of Risk Factors for Predicting Disease Severity. (24293080)
2013
6
Respiratory support in meconium aspiration syndrome: a practical guide. (22518190)
2012
7
Glucocorticoids in the treatment of neonatal meconium aspiration syndrome. (21465122)
2011
8
Serum cytokine and chemokine profiles in neonates with meconium aspiration syndrome. (18346989)
2008
9
Bronchoalveolar lavage plus surfactant in a piglet model of meconium aspiration syndrome. (17992018)
2008
10
Continuous positive airway pressure and conventional mechanical ventilation in the treatment of meconium aspiration syndrome. (19057611)
2008
11
Lung inflammation and pulmonary function in infants with meconium aspiration syndrome. (17722052)
2007
12
The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome. (16651329)
2006
13
Evidence based practice and the prevention and management of meconium aspiration syndrome. (16200397)
2005
14
Role of antibiotics in management of non-ventilated cases of meconium aspiration syndrome without risk factors for infection. (15467292)
2005
15
Predictability model of the need for extracorporeal membrane oxygenation in neonates with meconium aspiration syndrome treated with inhaled nitric oxide. (16034750)
2005
16
Treatment of severe meconium aspiration syndrome with porcine surfactant: a multicentre, randomized, controlled trial. (16188812)
2005
17
Surface properties and the meconium aspiration syndrome. (15080112)
2004
18
Modified protocols for surfactant therapy in experimental meconium aspiration syndrome. (12566684)
2003
19
The effects of prednisolone and serum malondialdehyde levels in puppies with experimentally induced meconium aspiration syndrome. (12760314)
2003
20
Meconium aspiration syndrome: a role for phospholipase A2 in the pathogenesis? (11332922)
2001
21
Meconium aspiration syndrome in term neonates with normal acid-base status at delivery: is it different? (11408862)
2001
22
Steroids in full term infants with respiratory failure and pulmonary hypertension due to meconium aspiration syndrome. (11277374)
2001
23
Meconium staining and meconium aspiration syndrome. Is there seasonal variation? (11399880)
2001
24
Surfactant for meconium aspiration syndrome in full term infants. (10796463)
2000
25
Surfactant tracheobronchial lavage for the management of a rabbit model of meconium aspiration syndrome. (10971006)
2000
26
Current strategy for management of meconium aspiration syndrome. (11100520)
2000
27
Combined effects of high-frequency ventilation and surfactant treatment in experimental meconium aspiration syndrome. (10027019)
1999
28
Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome. (10364225)
1999
29
Surfactant lavage for meconium aspiration syndrome: a pilot study. (10224181)
1999
30
Meconium aspiration syndrome: importance of the monitoring of labor. (9527946)
1998
31
Contemporary treatment options for meconium aspiration syndrome. (9575271)
1998
32
Surfactant replacement therapy for meconium aspiration syndrome. (8545223)
1996
33
Risk factors for meconium aspiration syndrome. (7617354)
1995
34
A study of meconium staining and meconium aspiration syndrome in a maternity hospital. (7656360)
1995
35
Meconium aspiration syndrome: recent concepts. (7883334)
1994
36
Improved oxygenation with exogenous surfactant administration in experimental meconium aspiration syndrome. (8165041)
1994
37
Meconium aspiration syndrome and neonatal outcome in a developing country. (7516134)
1994
38
Meconium aspiration syndrome: recent concepts. (8406707)
1993
39
Prediction of the severity of meconium aspiration syndrome. (8333477)
1993
40
Prince Edward Island. Meconium aspiration syndrome in neonatal calves. (17423723)
1991
41
Extracorporeal membrane oxygenation as treatment of severe meconium aspiration syndrome. (2734633)
1989
42
Failure to prevent meconium aspiration syndrome. (3347418)
1988
43
Pulmonary function in children after neonatal meconium aspiration syndrome. (3365005)
1988
44
Experimental meconium aspiration syndrome in the preterm fetal lamb: successful treatment using the extracorporeal artificial lung. (6424302)
1983
45
Meconium aspiration syndrome in the newborn. (6556998)
1983
46
Roentgenologic changes in meconium aspiration syndrome: review and report of case. (7251410)
1981
47
Intrauterine meconium aspiration syndrome. (7439009)
1980
48
Pathophysiology and prevention of meconium aspiration syndrome. (7373268)
1980
49
A delivery room approach to the meconium aspiration syndrome (MAS). Immediate intubation, endotracheal suction, and oxygen administration can reduce morbidity and mortality. (844234)
1977
50
The effect of tolazoline on right-to-left shunting via a patent ductus arteriosus in meconium aspiration syndrome. (803084)
1976

Genetic Variations for Meconium Aspiration Syndrome

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Expression for genes affiliated with Meconium Aspiration Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meconium Aspiration Syndrome

Search GEO for disease gene expression data for Meconium Aspiration Syndrome.

Pathways for genes affiliated with Meconium Aspiration Syndrome

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Sources:
52R&D Systems, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Meconium Aspiration Syndrome

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1valine4410.5TTN
2popg4410.4PLA2G6, SFTPB
3dppc4410.3SFTPB, PLA2G6
4pge24410.3CSF2, PLA2G10
5p-opc4410.2SFTPB, PLA2G6
6thapsigargin44 5911.2PLA2G6, OXT
7cicaprost44 2811.1CSF2, EDN1
8cyclosporin a44 28 5912.1EDN1, CSF3
9estradiol benzoate4410.1PLA2G6, OXT
10txb24410.1PLA2G10, EDN1, PLA2G6
11romurtide4410.1CSF2, CSF3
12molgramostim4410.0CSF2, CSF3
13pegfilgrastim44 1111.0CSF2, CSF3
14mesna4410.0CSF2, CSF3
15thiotepa44 49 1112.0CSF2, CSF3
16mafosfamide4410.0CSF2, CSF3
17ara-ctp4410.0CSF3, CSF2
18ozone4410.0SCGB1A1, SFTPB
194-hydroperoxycyclophosphamide449.9CSF3, CSF2
20pixy321449.9CSF2, CSF3
21glutamate449.9TTN, SLC6A11
22fluoride449.9CSF2, PLA2G6, OXT
23bleomycin44 1110.7CSF2, SFTPB, CSF3
24phospholipid449.7PLA2G10, SCGB1A1, SFTPB, PLA2G6
25prostaglandin f2alpha449.7OXT, PLA2G6, EDN1, SFTPB
26amifostine44 1110.7CSF2, CSF3
27gp 130449.6CSF2, SCGB1A1, CSF3
28actinomycin d449.6SFTPB, CSF2, EDN1, PLA2G6
29nifedipine44 49 28 1112.6PLA2G6, OXT, EDN1, CSF2
30vincristine44 49 1111.6PLA2G6, CSF2, CSF3
31mip 1alpha449.5CCL4, CSF2
32idarubicin44 49 1111.5CSF3, CSF2
33n1-acetylspermidine44 2410.5SMOX, PAOX
34potassium chloride44 1110.5EDN1, OXT
35amphotericin b449.4CCL4, CSF3, CSF2
36sb 20358044 5910.4CCL4, PLA2G6, CSF2, EDN1
37(+-)-pgf2-alpha449.4PLA2G6, OXT, SFTPB, CCL4
38histamine44 28 2411.3CCL4, PLA2G6, EDN1, CSF2
39endotoxin449.2CSF2, SCGB1A1, CCL4, CSF3
40arachidonic acid44 28 11 2412.0OXT, PLA2G6, PLA2G10, EDN1, SCGB1A1, CSF2
41oxygen44 2410.0SMOX, PAOX, SCGB1A1, SFTPB
42phosphatidylinositol448.9CSF2, SCGB1A1, EDN1, CCL4, PLA2G6
43dexamethasone44 49 28 1111.8PLA2G6, CSF3, CSF2, SFTPB, CCL4
44nitric oxide44 11 2410.8SCGB1A1, EDN1, CCL4, OXT, SFTPB
45cycloheximide448.7CSF3, PLA2G6, CCL4, CSF2, SFTPB, EDN1
46creatinine448.7OXT, EDN1, CCL4, PLA2G6, TTN, SCGB1A1
47cysteine448.6TTN, OXT, CSF2, SFTPB, PLA2G6, CCL4
48vegf448.5OXT, SFTPB, CCL4, CSF2, EDN1, CSF3
49retinoic acid44 249.5PLA2G6, CCL4, SFTPB, CSF2, CSF3, OXT
50calcium44 49 11 2410.7SFTPB, SCGB1A1, EDN1, OXT, TTN, PLA2G6

GO Terms for genes affiliated with Meconium Aspiration Syndrome

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16Gene Ontology
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Cellular components related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1PLA2G10, TTN, OXT, EDN1, CSF2, CCL4
2extracellular spaceGO:0056157.5OXT, CCL4, SFTPB, CSF2, CSF3, SCGB1A1

Biological processes related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of arachidonic acid secretionGO:09023810.2PLA2G6, PLA2G10
2epithelial fluid transportGO:04204510.1CSF2, EDN1
3phosphatidylcholine acyl-chain remodelingGO:0361519.9PLA2G10, PLA2G6
4positive regulation of macrophage derived foam cell differentiationGO:0107449.9PLA2G10, CSF2
5positive regulation of prostaglandin secretionGO:0323089.9PLA2G10, OXT
6positive regulation of renal sodium excretionGO:0358159.9OXT, EDN1
7regulation of sensory perception of painGO:0519309.7OXT, EDN1
8elevation of cytosolic calcium ion concentrationGO:0072049.6EDN1, OXT, PLA2G6
9phosphatidylethanolamine acyl-chain remodelingGO:0361529.6PLA2G10, PLA2G6
10polyamine catabolic processGO:0065989.4SMOX, PAOX
11spermine catabolic processGO:0462089.4SMOX, PAOX
12polyamine biosynthetic processGO:0065969.3SMOX, PAOX
13polyamine metabolic processGO:0065959.1PAOX, SMOX

Molecular functions related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.9PLA2G10, PLA2G6
2polyamine oxidase activityGO:0465929.1SMOX, PAOX
3spermine:oxygen oxidoreductase (spermidine-forming) activityGO:0529019.0SMOX, PAOX
4cytokine activityGO:0051258.4CCL4, CSF2, CSF3, EDN1

Products for genes affiliated with Meconium Aspiration Syndrome

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  • Antibodies
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Sources for Meconium Aspiration Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet