MAS
MCID: MCN007
MIFTS: 52

Meconium Aspiration Syndrome (MAS) malady

Fetal diseases, Respiratory diseases categories

Summaries for Meconium Aspiration Syndrome

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Meconium aspiration syndrome is a serious condition in which a newborn breathes a mixture of meconium and amniotic fluid into the lungs around the time of delivery. this can cause breathing difficulties due to swelling (inflammation) in the baby's lungs after birth. treatment may include suctioning the newborn's mouth as soon as the head emerges during delivery, deep suctioning of the windpipe, antibiotics to treat infection, oxygen to keep blood levels normal, and radiant heat to maintain body temperature. in severe cases, the baby may need assistance breathing (ventilator). last updated: 1/12/2012

MalaCards: Meconium Aspiration Syndrome, also known as neonatal aspiration, unspecified, is related to hypertension and dermatitis. An important gene associated with Meconium Aspiration Syndrome is SFTPB (surfactant protein B), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and melatonin degradation II. The compounds valine and popg have been mentioned in the context of this disorder. Affiliated tissues include lung and uterus.

Wikipedia:63 Meconium aspiration syndrome (MAS, alternatively \"Neonatal aspiration of meconium\") is a medical... more...

Aliases & Classifications for Meconium Aspiration Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
meconium aspiration syndrome:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

meconium aspiration syndrome 8 42 10 44 48 60
neonatal aspiration, unspecified 60
neonatal aspiration of meconium 8
meconium aspiration 8
mas 42


External Ids:

Disease Ontology8 DOID:11049
MeSH34 D008471
NCIt39 C87093
MESH via Orphanet35 D008471
ICD10 via Orphanet26 P24.0
SNOMED-CT via Orphanet57 206292002
UMLS via Orphanet61 C0025048

Related Diseases for Meconium Aspiration Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Meconium Aspiration Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.8EDN1
2dermatitis30.2PLA2G6, CSF2
3pancreatitis30.2PLA2G6
4respiratory failure30.2SFTPB, SCGB1A1, TTN
5asthma30.2CCL4, SFTPB, CSF2, SCGB1A1, EDN1, PLA2G6
6malaria29.8PLA2G6
7adenocarcinoma29.8SFTPB, SCGB1A1
8astrocytoma29.7PLA2G6, CCL4
9mccune albright syndrome10.3
10migraine with aura10.2
11edwards syndrome10.2
12patent ductus arteriosus10.2
13endocarditis10.2
14thrombocytopenia10.2
15migraine10.1
16interstitial emphysema10.1
17aspiration pneumonitis10.1
18stroke, ischemic10.0
19atopic dermatitis10.0
20cerebritis10.0
21infertility10.0
22diffuse large b-cell lymphoma10.0
23contact dermatitis10.0
24congenital diaphragmatic hernia10.0SFTPB
25meningioma10.0PLA2G6
26rhinitis10.0SCGB1A1
27cor pulmonale10.0EDN1
28peritonitis10.0PLA2G6
29disseminated intravascular coagulation10.0OXT
30meningitis10.0CCL4
31hepatopulmonary syndrome10.0EDN1
32human immunodeficiency virus infectious disease10.0CCL4
33glaucoma10.0EDN1
34capillary leak syndrome10.0CSF2
35sickle cell disease10.0EDN1, PLA2G10
36bronchopulmonary dysplasia10.0SCGB1A1, SFTPB
37pulmonary fibrosis10.0EDN1, CCL4
38sarcoidosis10.0SCGB1A1, CCL4
39pulmonary alveolar proteinosis10.0CSF2, SFTPB
40acute chest syndrome10.0PLA2G10
41cystic fibrosis10.0SFTPB, SCGB1A1, PLA2G6
42adult respiratory distress syndrome10.0SFTPB, PLA2G6
43cervical cancer10.0SMOX
44neuropathy10.0TTN
45newborn respiratory distress syndrome10.0TTN
46glomerulonephritis10.0CCL4, SCGB1A1, PLA2G6
47arthritis10.0CCL4, CSF2, PLA2G6
48lung benign neoplasm10.0SFTPB, SCGB1A1, OXT
49lung cancer10.0CSF2, CSF3
50severe congenital neutropenia autosomal recessive 310.0CSF2, CSF3

Graphical network of the top 20 diseases related to Meconium Aspiration Syndrome:



Diseases related to meconium aspiration syndrome

Clinical Features for Meconium Aspiration Syndrome

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Drugs & Therapeutics for Meconium Aspiration Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Meconium Aspiration Syndrome

Genetic Tests for Meconium Aspiration Syndrome

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Anatomical Context for Meconium Aspiration Syndrome

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32MalaCards
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MalaCards organs/tissues related to Meconium Aspiration Syndrome:

32
Lung, Uterus

Animal Models for Meconium Aspiration Syndrome or affiliated genes

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Publications for Meconium Aspiration Syndrome

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50PubMed
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Articles related to Meconium Aspiration Syndrome:

(show top 50)    (show all 260)
idTitleAuthorsYear
1
Comparative effects of bronchoalveolar lavage with saline, surfactant, or perfluorocarbon in experimental meconium aspiration syndrome. (22079955)
2012
2
Mortality in meconium aspiration syndrome in hospitalized babies. (22078351)
2011
3
Intratracheal catheter suction removes the same volume of meconium with less impact on desaturation compared with meconium aspirator in meconium aspiration syndrome. (20634007)
2010
4
Surfactant lavage decreases systemic interleukin-1 beta production in meconium aspiration syndrome. (19919635)
2010
5
Prevention of meconium aspiration syndrome: an update and the Baylor experience. (19381312)
2009
6
Role of meconium in the reaction of airways smooth musculature in the newborn with meconium aspiration syndrome (MAS). (20002002)
2009
7
Polyethylene glycol addition does not improve exogenous surfactant function in an experimental model of meconium aspiration syndrome. (19191106)
2009
8
Early human development at the perinatal interface: meconium stained amniotic fluid (MSAF) and meconium aspiration syndrome (MAS). (19822400)
2009
9
Bronchoalveolar lavage with pulmonary surfactant/dextran mixture improves meconium clearance and lung functions in experimental meconium aspiration syndrome. (17952467)
2008
10
Angiotensin II in apoptotic lung injury: potential role in meconium aspiration syndrome. (19057599)
2008
11
Albumin lavage does not improve the outcome of meconium aspiration syndrome. (19012188)
2008
12
The role of complement in meconium aspiration syndrome. (19057601)
2008
13
CC10 reduces inflammation in meconium aspiration syndrome in newborn piglets. (17957145)
2007
14
ECMO for meconium aspiration syndrome: support for relaxed entry criteria. (17667237)
2007
15
Effects of a recombinant surfactant protein-C-based surfactant on lung function and the pulmonary surfactant system in a model of meconium aspiration syndrome. (16374175)
2006
16
ACOG Committee Opinion Number 346, October 2006: amnioninfusion does not prevent meconium aspiration syndrome. (17012484)
2006
17
Surfactant therapy for meconium aspiration syndrome: current status. (16392874)
2005
18
System-based strategy for the management of meconium aspiration syndrome: 198 consecutive cases observations. (16302581)
2005
19
Surfactant lavage for extracorporeal membrane oxygenation-requiring meconium aspiration syndrome--a cheap alternative. (15726410)
2005
20
Meconium-stained amniotic fluid, meconium aspiration syndrome, and persistent pulmonary hypertension of the newborn. (15624362)
2004
21
Different doses of exogenous surfactant for treatment of meconium aspiration syndrome in newborn rabbits. (15286829)
2004
22
Racial disparity in meconium-stained amniotic fluid and meconium aspiration syndrome in the United States, 1989-2000. (14662213)
2003
23
A multicenter, randomized, controlled trial comparing Surfaxin (Lucinactant) lavage with standard care for treatment of meconium aspiration syndrome. (12042546)
2002
24
Nucleated red blood cells in meconium aspiration syndrome. (11275033)
2001
25
Incidence of meconium aspiration syndrome in term meconium-stained babies managed at birth with selective tracheal intubation. (11776676)
2001
26
The use of intratracheal pulmonary ventilation and partial liquid ventilation in newborn piglets with meconium aspiration syndrome. (12797892)
2001
27
Meconium aspiration syndrome and extracorporeal membrane oxygenation. (11124912)
2001
28
Severe meconium aspiration syndrome is not caused by aspiration of meconium. (11641681)
2001
29
Effect of nitric oxide and high-frequency oscillatory ventilation in meconium aspiration syndrome. (12813270)
2000
30
The role of pulmonary inflammation in the development of pulmonary hypertension in newborn with meconium aspiration syndrome (MAS). (10093144)
1999
31
Effects of dexamethasone on meconium aspiration syndrome in newborn piglets. (10447112)
1999
32
Meconium aspiration syndrome: pathophysiology and prevention. (10612363)
1999
33
Selective tracheal suctioning to prevent meconium aspiration syndrome. (9989895)
1998
34
The meconium aspiration syndrome: the saga continues. (10216539)
1998
35
Effect of nitric oxide in meconium aspiration syndrome after treatment with surfactant. (9377892)
1997
36
A 3-year review of meconium aspiration syndrome. (9259600)
1997
37
Risk factors for meconium-aspiration syndrome. (9006821)
1996
38
Contribution of airway hyperresponsiveness to lower airway obstruction after extracorporeal membrane oxygenation for meconium aspiration syndrome. (7712766)
1995
39
Meconium staining and the meconium aspiration syndrome. Unresolved issues. (8414717)
1993
40
Meconium aspiration syndrome: the role of resuscitation and tracheal suction in prevention. (1627056)
1992
41
Meconium aspiration syndrome. (2674415)
1989
42
Fatal meconium aspiration syndrome occurring despite airway management considered appropriate. (3976781)
1985
43
The relationship of thrombocytopenia to the onset of persistent pulmonary hypertension of the newborn in the meconium aspiration syndrome. (3860753)
1985
44
Meconium aspiration syndrome. (4061528)
1985
45
Coproporphyrin in urine of newborns with meconium aspiration syndrome. (6640899)
1983
46
Prevention of meconium aspiration syndrome in newborn infants. (660325)
1978
47
Meconium aspiration syndrome. Neonatal and follow-up study. (80135)
1978
48
Meconium aspiration syndrome following cesarean section. (629321)
1978
49
Hydrocortisone therapy in meconium aspiration syndrome: a controlled study. (830880)
1977
50
Assisted ventilation in infants with meconium aspiration syndrome. (240148)
1975

Genetic Variations for Meconium Aspiration Syndrome

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Expression for genes affiliated with Meconium Aspiration Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meconium Aspiration Syndrome

Search GEO for disease gene expression data for Meconium Aspiration Syndrome.

Pathways for genes affiliated with Meconium Aspiration Syndrome

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Sources:
52R&D Systems, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Meconium Aspiration Syndrome

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1valine4410.5TTN
2popg4410.4SFTPB, PLA2G6
3dppc4410.3SFTPB, PLA2G6
4pge24410.3PLA2G10, CSF2
5p-opc4410.2SFTPB, PLA2G6
6thapsigargin44 5911.2PLA2G6, OXT
7cicaprost44 2811.1CSF2, EDN1
8cyclosporin a44 28 5912.1EDN1, CSF3
9estradiol benzoate4410.1PLA2G6, OXT
10txb24410.1EDN1, PLA2G6, PLA2G10
11romurtide4410.1CSF2, CSF3
12molgramostim4410.0CSF2, CSF3
13pegfilgrastim44 1111.0CSF3, CSF2
14mesna4410.0CSF2, CSF3
15thiotepa44 49 1112.0CSF3, CSF2
16ara-ctp4410.0CSF2, CSF3
17mafosfamide4410.0CSF2, CSF3
18ozone4410.0SCGB1A1, SFTPB
194-hydroperoxycyclophosphamide449.9CSF3, CSF2
20pixy321449.9CSF2, CSF3
21glutamate449.9TTN, SLC6A11
22fluoride449.9PLA2G6, OXT, CSF2
23bleomycin44 1110.7CSF3, CSF2, SFTPB
24phospholipid449.7SFTPB, SCGB1A1, PLA2G6, PLA2G10
25prostaglandin f2alpha449.7SFTPB, EDN1, OXT, PLA2G6
26amifostine44 1110.7CSF2, CSF3
27gp 130449.6CSF2, CSF3, SCGB1A1
28actinomycin d449.6PLA2G6, EDN1, CSF2, SFTPB
29nifedipine44 49 28 1112.6CSF2, EDN1, OXT, PLA2G6
30vincristine44 49 1111.6PLA2G6, CSF3, CSF2
31mip 1alpha449.5CSF2, CCL4
32idarubicin44 49 1111.5CSF2, CSF3
33n1-acetylspermidine44 2410.5PAOX, SMOX
34potassium chloride44 1110.5OXT, EDN1
35amphotericin b449.4CCL4, CSF2, CSF3
36sb 20358044 5910.4CCL4, CSF2, EDN1, PLA2G6
37(+-)-pgf2-alpha449.4PLA2G6, OXT, SFTPB, CCL4
38histamine44 28 2411.3PLA2G6, EDN1, CSF2, CCL4
39endotoxin449.2CCL4, CSF2, CSF3, SCGB1A1
40arachidonic acid44 28 11 2412.0CSF2, SCGB1A1, EDN1, OXT, PLA2G6, PLA2G10
41oxygen44 2410.0SMOX, PAOX, SCGB1A1, SFTPB
42phosphatidylinositol448.9CCL4, CSF2, SCGB1A1, EDN1, PLA2G6
43dexamethasone44 49 28 1111.8CCL4, SFTPB, CSF2, CSF3, PLA2G6
44nitric oxide44 11 2410.8CCL4, SFTPB, SCGB1A1, EDN1, OXT
45cycloheximide448.7CCL4, SFTPB, CSF2, CSF3, EDN1, PLA2G6
46creatinine448.7CCL4, SCGB1A1, EDN1, OXT, TTN, PLA2G6
47cysteine448.6CCL4, SFTPB, CSF2, OXT, TTN, PLA2G6
48vegf448.5CCL4, SFTPB, CSF2, CSF3, EDN1, OXT
49retinoic acid44 249.5CSF3, CSF2, SFTPB, CCL4, OXT, PLA2G6
50calcium44 49 11 2410.7CCL4, SFTPB, SCGB1A1, EDN1, OXT, CDH12

GO Terms for genes affiliated with Meconium Aspiration Syndrome

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16Gene Ontology
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Cellular components related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1PLA2G10, TTN, OXT, EDN1, CSF2, CCL4
2extracellular spaceGO:0056157.5OXT, CCL4, SFTPB, CSF2, CSF3, SCGB1A1

Biological processes related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of arachidonic acid secretionGO:09023810.2PLA2G6, PLA2G10
2epithelial fluid transportGO:04204510.1CSF2, EDN1
3phosphatidylcholine acyl-chain remodelingGO:0361519.9PLA2G10, PLA2G6
4positive regulation of macrophage derived foam cell differentiationGO:0107449.9PLA2G10, CSF2
5positive regulation of prostaglandin secretionGO:0323089.9PLA2G10, OXT
6positive regulation of renal sodium excretionGO:0358159.9OXT, EDN1
7regulation of sensory perception of painGO:0519309.7OXT, EDN1
8elevation of cytosolic calcium ion concentrationGO:0072049.6EDN1, OXT, PLA2G6
9phosphatidylethanolamine acyl-chain remodelingGO:0361529.6PLA2G10, PLA2G6
10polyamine catabolic processGO:0065989.4SMOX, PAOX
11spermine catabolic processGO:0462089.4SMOX, PAOX
12polyamine biosynthetic processGO:0065969.3SMOX, PAOX
13polyamine metabolic processGO:0065959.1PAOX, SMOX

Molecular functions related to Meconium Aspiration Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.9PLA2G10, PLA2G6
2polyamine oxidase activityGO:0465929.1SMOX, PAOX
3spermine:oxygen oxidoreductase (spermidine-forming) activityGO:0529019.0SMOX, PAOX
4cytokine activityGO:0051258.4CCL4, CSF2, CSF3, EDN1

Products for genes affiliated with Meconium Aspiration Syndrome

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Sources for Meconium Aspiration Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet