MCID: MDN001
MIFTS: 28

Median Rhomboid Glossitis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Median Rhomboid Glossitis

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Aliases & Descriptions for Median Rhomboid Glossitis:

Name: Median Rhomboid Glossitis 11 13
 
Persistent Tuberculum Impar 11

Classifications:



External Ids:

Disease Ontology11 DOID:14111
ICD1029 K14.2
SNOMED-CT61 7522008
ICD9CM31 529.2

Summaries for Median Rhomboid Glossitis

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Wikipedia:70 Median rhomboid glossitis (MRG, also known as central papillary atrophy, or glossal central papillary... more...

MalaCards based summary: Median Rhomboid Glossitis, also known as persistent tuberculum impar, is related to glossitis and cholesteatoma of attic. An important gene associated with Median Rhomboid Glossitis is KRT6B (Keratin 6B), and among its related pathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include tongue, and related mouse phenotypes are digestive/alimentary and integument.

Related Diseases for Median Rhomboid Glossitis

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Diseases related to Median Rhomboid Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1glossitis10.8
2cholesteatoma of attic10.5KRT6A, KRT6B
3abnormal pupillary function10.4KRT16, KRT6A
4otosclerosis10.4KRT16, KRT17
5histiocytosis10.4KRT16, KRT6A
6keratosis palmoplantaris striata iii10.4KRT16, KRT17
7craniodiaphyseal dysplasia, autosomal dominant10.3KRT16, KRT17
8lipomatosis10.3KRT16, KRT17
9fissured tongue10.2
10geographic tongue10.2
11abnormal threshold of rods10.2B2M, TTR
12ichthyosis, cyclic, with epidermolytic hyperkeratosis10.2KRT16, KRT17
13lesion of sciatic nerve10.2B2M, TTR
14epidermolysis bullosa simplex, dowling-meara type10.2KRT16, KRT6A, KRT6B
15chronic salpingitis10.2B2M, TTR
16bone lymphoma10.2B2M, TTR
17familial retinoblastoma10.2KRT16, KRT17
18candidiasis10.2
19hypotrichosis 610.2B2M, TTR
20chronic lymphocytic leukemia10.1TF, TTR
21sclerosteosis 110.1KRT16, KRT17, KRT6B
22plummer's disease10.1TF, TTR
23hematocele of tunica vaginalis testis10.1TF, TTR
24pancreatic vasoactive intestinal peptide producing tumor10.1B2M, TTR
25alveolar periostitis10.1TF, TTR
26afibrinogenemia, congenital10.1B2M, TTR
27balantidiasis10.0TF, TTR
28urinary bladder posterior wall cancer10.0TF, TTR
29ovarian cystic teratoma10.0TF, TTR
30central nervous system adult germ cell tumor10.0TF, TTR
31sarcoma10.0
32hairy tongue10.0
33breast mucoepidermoid carcinoma9.9B2M, TF
34gonadal dysgenesis9.9B2M, CD4
35rh isoimmunization9.8B2M, CD4
36pachyonychia congenita 29.8KRT16, KRT17, KRT6A, KRT6B
37lissencephaly9.8KRT16, KRT17, KRT6A, KRT6B
38ectodermal dysplasia 4, hair/nail type9.8KRT16, KRT17, KRT6A, KRT6B
39persistent generalized lymphadenopathy9.8CD4, TF
40hypothyroidism9.8KRT16, KRT6A, KRT6B, TTR
41lung sarcoma9.8CD4, KRT16
42heart leiomyosarcoma9.7B2M, CD4
43chronic myelomonocytic leukemia9.7B2M, TF, TTR
44taylor's syndrome9.6B2M, CD4
45hemolytic anemia9.6B2M, CD4
46organ system benign neoplasm9.5B2M, CD4
47perianal skin paget's disease9.5CD4, TF
48central pontine myelinolysis9.3B2M, CD4

Graphical network of the top 20 diseases related to Median Rhomboid Glossitis:



Diseases related to median rhomboid glossitis

Symptoms for Median Rhomboid Glossitis

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Drugs & Therapeutics for Median Rhomboid Glossitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Median Rhomboid Glossitis

Genetic Tests for Median Rhomboid Glossitis

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Anatomical Context for Median Rhomboid Glossitis

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MalaCards organs/tissues related to Median Rhomboid Glossitis:

35
Tongue

Animal Models for Median Rhomboid Glossitis or affiliated genes

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MGI Mouse Phenotypes related to Median Rhomboid Glossitis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8B2M, CD4, KRT16, KRT17, KRT6B
2MP:00107718.0B2M, CD4, KRT16, KRT17, KRT6B

Publications for Median Rhomboid Glossitis

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Articles related to Median Rhomboid Glossitis:

(show all 43)
idTitleAuthorsYear
1
Median rhomboid glossitis-developmental or candidal? (26523164)
2015
2
Application of the novel method in the diagnosis and treatment of median rhomboid glossitis Candida-associated. (24966760)
2014
3
Diagnostic discussion. Median rhomboid glossitis (MRG). (24579425)
2013
4
Median rhomboid glossitis: a clinical and microbiological study. (21912494)
2011
5
Median rhomboid glossitis. (21446620)
2011
6
The prevalence of median rhomboid glossitis in diabetic patients: a case-control study. (22737518)
2011
7
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. (20339702)
2010
8
A classic case of median rhomboid glossitis. (19601454)
2009
9
Median rhomboid glossitis. (17990677)
2007
10
Partial atrophic tongue other than median rhomboid glossitis. (17441970)
2007
11
Pachyonychia congenita associated with median rhomboid glossitis. (17511954)
2007
12
Diagnostic quiz. Case No. 1: median rhomboid glossitis. (17632961)
2006
13
Kaposi's sarcoma of the tongue associated with median rhomboid glossitis in a non-AIDS patient. A case report. (15274372)
2004
14
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. (15316160)
2004
15
A case of median rhomboid glossitis. (12773811)
2003
16
Oral pathology quiz #2. Median rhomboid glossitis. (11808366)
2001
17
Median rhomboid glossitis and a "kissing" lesion of the palate. (8936507)
1996
18
Cause of median rhomboid glossitis. (8705579)
1996
19
Median rhomboid glossitis. (8899768)
1996
20
Median rhomboid glossitis. An oral manifestation in patients infected with HIV. (8078660)
1994
21
Squamous cell carcinoma mimicking median rhomboid glossitis region: report of a case. (8509924)
1993
22
Quantitative evaluation of Langerhans cells in median rhomboid glossitis. (1593492)
1992
23
Median rhomboid glossitis: secondary to colonisation of the tongue by Actinomyces (a case report). (1841980)
1991
24
Median rhomboid glossitis: review of a puzzling entity. (2097050)
1990
25
Candida albicans in median rhomboid glossitis. A postmortem study. (3088163)
1986
26
Median rhomboid glossitis. A follow-up study of 16 patients. (3459824)
1986
27
Median rhomboid glossitis in an infant. Report of a case. (3861810)
1985
28
Tobacco smoking and denture wearing as local aetiological factors in median rhomboid glossitis. (6438002)
1984
29
Chronic candidiasis of the rat tongue: a possible model for human median rhomboid glossitis. (6958728)
1982
30
Median rhomboid glossitis caused by Candida? (282562)
1979
31
Median rhomboid glossitis: not a misnomer. Review of the literature and histologic study of twenty-eight cases. (366496)
1978
32
Median rhomboid glossitis associated with amyloid deposition. (676752)
1978
33
Carcinoma arising in the area of median rhomboid glossitis. (1063965)
1976
34
Median rhomboid glossitis. Candidiasis and not a developmental anomaly. (1201190)
1975
35
Median rhomboid glossitis. Case report. (4713826)
1973
36
Median rhomboid glossitis: a developmental anomaly? (5275506)
1971
37
Prevalence of geographic tongue, fissured tongue, median rhomboid glossitis, and hairy tongue among 3,611 Minnesota schoolchildren. (5270895)
1970
38
Median rhomboid glossitis. Case report. (5353692)
1969
39
Incidence of geographic tongue and median rhomboid glossitis in 3,319 Negro college students. (5245682)
1968
40
Median rhomboid glossitis: an atypical variant. (5234276)
1967
41
Median rhomboid glossitis; case reported in an infant. (13125261)
1954
42
The occurrence of Fordyce spots, benign migratory glossitis, median rhomboid glossitis, and fissured tongue in 2,478 dental patients. (13088005)
1953
43
Median rhomboid glossitis; report of a case. (13013723)
1952

Variations for Median Rhomboid Glossitis

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Expression for genes affiliated with Median Rhomboid Glossitis

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Search GEO for disease gene expression data for Median Rhomboid Glossitis.

Pathways for genes affiliated with Median Rhomboid Glossitis

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Pathways related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.4KRT17, KRT6A, KRT6B
2
Show member pathways
9.3KRT16, KRT17, KRT6A

GO Terms for genes affiliated with Median Rhomboid Glossitis

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Cellular components related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1HFE-transferrin receptor complexGO:199071210.0B2M, TF
2intermediate filamentGO:00058829.8KRT16, KRT17, KRT6A
3extracellular exosomeGO:00700627.4B2M, KRT16, KRT17, KRT6A, KRT6B, TF

Biological processes related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeleton organizationGO:00451049.9KRT16, KRT6A
2keratinizationGO:00314249.9KRT16, KRT17
3iron ion homeostasisGO:00550729.7B2M, TF
4cellular response to iron ionGO:00712819.7B2M, TF
5positive regulation of receptor-mediated endocytosisGO:00482609.6B2M, TF
6retina homeostasisGO:00018959.5B2M, TF
7defense response to Gram-negative bacteriumGO:00508299.1B2M, CD4
8regulation of defense response to virus by virusGO:00506908.8B2M, CD4

Molecular functions related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein bindingGO:00422899.9CD4, KRT17
2glycoprotein bindingGO:00019489.7B2M, CD4
3structural constituent of cytoskeletonGO:00052009.5KRT16, KRT17, KRT6A, KRT6B
4protein bindingGO:00055156.1B2M, CD4, KRT16, KRT17, KRT6A, KRT6B

Sources for Median Rhomboid Glossitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet