MCID: MDN001
MIFTS: 29

Median Rhomboid Glossitis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Median Rhomboid Glossitis

Aliases & Descriptions for Median Rhomboid Glossitis:

Name: Median Rhomboid Glossitis 12 14
Persistent Tuberculum Impar 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14111
ICD10 33 K14.2
ICD9CM 35 529.2
SNOMED-CT 64 7522008
UMLS 69 C0155963

Summaries for Median Rhomboid Glossitis

MalaCards based summary : Median Rhomboid Glossitis, also known as persistent tuberculum impar, is related to glossitis and geographic tongue. An important gene associated with Median Rhomboid Glossitis is KRT6B (Keratin 6B), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include tongue, and related phenotypes are digestive/alimentary and integument

Wikipedia : 71 Median rhomboid glossitis (MRG, also known as central papillary atrophy, or glossal central papillary... more...

Related Diseases for Median Rhomboid Glossitis

Diseases related to Median Rhomboid Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
id Related Disease Score Top Affiliating Genes
1 glossitis 10.8
2 geographic tongue 10.2
3 fissured tongue 10.2
4 cholesteatoma of middle ear 10.2 KRT6A KRT6B
5 benign hypertensive renal disease 10.2 KRT16 KRT6A
6 chronic mountain sickness 10.2 KRT16 KRT17
7 dicrocoeliasis 10.2 KRT16 KRT17
8 white sponge nevus 1 10.2 KRT16 KRT17
9 craniodiaphyseal dysplasia, autosomal dominant 10.2 KRT16 KRT17
10 brachydactyly small stature face anomalies 10.2 KRT16 KRT17
11 distal arthrogryposis 10.2 KRT16 KRT17
12 candidiasis 10.2
13 hereditary lymphedema type ii 10.1 B2M TTR
14 denture stomatitis 10.1 B2M TTR
15 tibial nerve palsy 10.1 B2M TTR
16 scott syndrome 10.1 KRT16 KRT6A KRT6B
17 childhood vagina botryoid rhabdomyosarcoma 10.1 B2M TTR
18 epidermolysis bullosa simplex-mp 10.1 KRT16 KRT6A KRT6B
19 anaplastic ganglioglioma 10.1 B2M TTR
20 sclerosteosis 1 10.1 KRT16 KRT17 KRT6B
21 pancreatic vasoactive intestinal peptide producing tumor 10.1 B2M TTR
22 hypotrichosis 6 10.1 B2M TTR
23 male genital organ stricture 10.1 TF TTR
24 cataract 15, multiple types 10.1 KRT16 KRT17 KRT6A
25 female infertility of uterine origin 10.1 TF TTR
26 malignant spindle cell melanoma 10.1 KRT16 KRT17
27 lymphangitis 10.0 CD4 KRT6A
28 solar retinopathy 10.0 TF TTR
29 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 10.0 TF TTR
30 ichthyosis histrix, curth-macklin type 10.0 KRT16 KRT17
31 malignant hyperthermia susceptibility 1 10.0 B2M TF
32 hairy tongue 10.0
33 squamous cell carcinoma 10.0
34 sarcoma 10.0
35 spastic entropion 10.0 TF TTR
36 46 xy gonadal dysgenesis 10.0 B2M CD4
37 central nervous system origin vertigo 10.0 B2M TF
38 bladder sarcoma 10.0 TF TTR
39 pachyonychia congenita 2 10.0 KRT16 KRT17 KRT6A KRT6B
40 oral hairy leukoplakia 10.0 CD4 TF
41 focal epithelial hyperplasia 9.9 TF TTR
42 sclerosing cholangitis 9.9 B2M CD4
43 choriodal dystrophy, central areolar 2 9.9 B2M TF TTR
44 chronic myocardial ischemia 9.9 B2M TF TTR
45 inclusion conjunctivitis 9.9 B2M CD4
46 van maldergem syndrome 2 9.9 B2M TTR
47 papilledema 9.8 KRT16 KRT17 KRT6A KRT6B TTR
48 bacteriuria 8.8 B2M CD4 KRT16 KRT17 KRT6A KRT6B

Graphical network of the top 20 diseases related to Median Rhomboid Glossitis:



Diseases related to Median Rhomboid Glossitis

Symptoms & Phenotypes for Median Rhomboid Glossitis

MGI Mouse Phenotypes related to Median Rhomboid Glossitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 KRT17 KRT6B B2M CD4 KRT16
2 integument MP:0010771 9.02 B2M CD4 KRT16 KRT17 KRT6B

Drugs & Therapeutics for Median Rhomboid Glossitis

Search Clinical Trials , NIH Clinical Center for Median Rhomboid Glossitis

Genetic Tests for Median Rhomboid Glossitis

Anatomical Context for Median Rhomboid Glossitis

MalaCards organs/tissues related to Median Rhomboid Glossitis:

39
Tongue

Publications for Median Rhomboid Glossitis

Articles related to Median Rhomboid Glossitis:

(show all 43)
id Title Authors Year
1
Median rhomboid glossitis-developmental or candidal? ( 26523164 )
2015
2
Application of the novel method in the diagnosis and treatment of median rhomboid glossitis Candida-associated. ( 24966760 )
2014
3
Diagnostic discussion. Median rhomboid glossitis (MRG). ( 24579425 )
2013
4
Median rhomboid glossitis: a clinical and microbiological study. ( 21912494 )
2011
5
Median rhomboid glossitis. ( 21446620 )
2011
6
The prevalence of median rhomboid glossitis in diabetic patients: a case-control study. ( 22737518 )
2011
7
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. ( 20339702 )
2010
8
A classic case of median rhomboid glossitis. ( 19601454 )
2009
9
Median rhomboid glossitis. ( 17990677 )
2007
10
Partial atrophic tongue other than median rhomboid glossitis. ( 17441970 )
2007
11
Pachyonychia congenita associated with median rhomboid glossitis. ( 17511954 )
2007
12
Diagnostic quiz. Case No. 1: median rhomboid glossitis. ( 17632961 )
2006
13
Kaposi's sarcoma of the tongue associated with median rhomboid glossitis in a non-AIDS patient. A case report. ( 15274372 )
2004
14
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. ( 15316160 )
2004
15
A case of median rhomboid glossitis. ( 12773811 )
2003
16
Oral pathology quiz #2. Median rhomboid glossitis. ( 11808366 )
2001
17
Cause of median rhomboid glossitis. ( 8705579 )
1996
18
Median rhomboid glossitis. ( 8899768 )
1996
19
Median rhomboid glossitis and a "kissing" lesion of the palate. ( 8936507 )
1996
20
Median rhomboid glossitis. An oral manifestation in patients infected with HIV. ( 8078660 )
1994
21
Squamous cell carcinoma mimicking median rhomboid glossitis region: report of a case. ( 8509924 )
1993
22
Quantitative evaluation of Langerhans cells in median rhomboid glossitis. ( 1593492 )
1992
23
Median rhomboid glossitis: secondary to colonisation of the tongue by Actinomyces (a case report). ( 1841980 )
1991
24
Median rhomboid glossitis: review of a puzzling entity. ( 2097050 )
1990
25
Candida albicans in median rhomboid glossitis. A postmortem study. ( 3088163 )
1986
26
Median rhomboid glossitis. A follow-up study of 16 patients. ( 3459824 )
1986
27
Median rhomboid glossitis in an infant. Report of a case. ( 3861810 )
1985
28
Tobacco smoking and denture wearing as local aetiological factors in median rhomboid glossitis. ( 6438002 )
1984
29
Chronic candidiasis of the rat tongue: a possible model for human median rhomboid glossitis. ( 6958728 )
1982
30
Median rhomboid glossitis caused by Candida? ( 282562 )
1979
31
Median rhomboid glossitis associated with amyloid deposition. ( 676752 )
1978
32
Median rhomboid glossitis: not a misnomer. Review of the literature and histologic study of twenty-eight cases. ( 366496 )
1978
33
Carcinoma arising in the area of median rhomboid glossitis. ( 1063965 )
1976
34
Median rhomboid glossitis. Candidiasis and not a developmental anomaly. ( 1201190 )
1975
35
Median rhomboid glossitis. Case report. ( 4713826 )
1973
36
Median rhomboid glossitis: a developmental anomaly? ( 5275506 )
1971
37
Prevalence of geographic tongue, fissured tongue, median rhomboid glossitis, and hairy tongue among 3,611 Minnesota schoolchildren. ( 5270895 )
1970
38
Median rhomboid glossitis. Case report. ( 5353692 )
1969
39
Incidence of geographic tongue and median rhomboid glossitis in 3,319 Negro college students. ( 5245682 )
1968
40
Median rhomboid glossitis: an atypical variant. ( 5234276 )
1967
41
Median rhomboid glossitis; case reported in an infant. ( 13125261 )
1954
42
The occurrence of Fordyce spots, benign migratory glossitis, median rhomboid glossitis, and fissured tongue in 2,478 dental patients. ( 13088005 )
1953
43
Median rhomboid glossitis; report of a case. ( 13013723 )
1952

Variations for Median Rhomboid Glossitis

Expression for Median Rhomboid Glossitis

Search GEO for disease gene expression data for Median Rhomboid Glossitis.

Pathways for Median Rhomboid Glossitis

Pathways related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.81 KRT17 KRT6A KRT6B
2
Show member pathways
11.38 KRT16 KRT17 KRT6A KRT6B
3
Show member pathways
11.17 KRT16 KRT17 KRT6A

GO Terms for Median Rhomboid Glossitis

Cellular components related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 B2M KRT16 KRT17 KRT6A KRT6B TF
2 endoplasmic reticulum lumen GO:0005788 9.5 B2M CD4 TF
3 clathrin-coated vesicle membrane GO:0030665 9.26 CD4 TF
4 HFE-transferrin receptor complex GO:1990712 8.96 B2M TF
5 intermediate filament GO:0005882 8.92 KRT16 KRT17 KRT6A KRT6B

Biological processes related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.63 B2M TF TTR
2 cytoskeleton organization GO:0007010 9.58 KRT16 KRT6A KRT6B
3 defense response to Gram-negative bacterium GO:0050829 9.51 B2M CD4
4 iron ion homeostasis GO:0055072 9.49 B2M TF
5 retina homeostasis GO:0001895 9.48 B2M TF
6 regulation of defense response to virus by virus GO:0050690 9.43 B2M CD4
7 positive regulation of receptor-mediated endocytosis GO:0048260 9.37 B2M TF
8 intermediate filament cytoskeleton organization GO:0045104 9.32 KRT16 KRT6A
9 iron ion transport GO:0006826 9.26 B2M TF
10 keratinization GO:0031424 9.26 KRT16 KRT17 KRT6A KRT6B
11 cellular response to iron ion GO:0071281 9.16 B2M TF
12 cornification GO:0070268 8.92 KRT16 KRT17 KRT6A KRT6B

Molecular functions related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 B2M CD4 KRT16 KRT17 KRT6A KRT6B
2 structural molecule activity GO:0005198 9.33 KRT16 KRT17 KRT6A
3 glycoprotein binding GO:0001948 9.32 B2M CD4
4 MHC class II protein binding GO:0042289 8.96 CD4 KRT17
5 structural constituent of cytoskeleton GO:0005200 8.92 KRT16 KRT17 KRT6A KRT6B

Sources for Median Rhomboid Glossitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
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54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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