MCID: MDN001
MIFTS: 29

Median Rhomboid Glossitis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Median Rhomboid Glossitis

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Aliases & Descriptions for Median Rhomboid Glossitis:

Name: Median Rhomboid Glossitis 11 13
 
Persistent Tuberculum Impar 11

Classifications:



External Ids:

Disease Ontology11 DOID:14111
ICD1030 K14.2
SNOMED-CT62 7522008
ICD9CM32 529.2

Summaries for Median Rhomboid Glossitis

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Wikipedia:71 Median rhomboid glossitis (MRG, also known as central papillary atrophy, or glossal central papillary... more...

MalaCards based summary: Median Rhomboid Glossitis, also known as persistent tuberculum impar, is related to glossitis and fissured tongue. An important gene associated with Median Rhomboid Glossitis is KRT6B (Keratin 6B), and among its related pathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include tongue, and related mouse phenotypes are digestive/alimentary and integument.

Related Diseases for Median Rhomboid Glossitis

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Diseases related to Median Rhomboid Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1glossitis10.8
2fissured tongue10.2
3geographic tongue10.2
4cholesteatoma of middle ear10.2KRT6A, KRT6B
5benign hypertensive renal disease10.2KRT16, KRT6A
6chronic mountain sickness10.2KRT16, KRT17
7dicrocoeliasis10.2KRT16, KRT17
8white sponge nevus 110.2KRT16, KRT17
9craniodiaphyseal dysplasia, autosomal dominant10.2KRT16, KRT17
10brachydactyly small stature face anomalies10.2KRT16, KRT17
11distal arthrogryposis10.2KRT16, KRT17
12candidiasis10.2
13hereditary lymphedema type ii10.1B2M, TTR
14denture stomatitis10.1B2M, TTR
15tibial nerve palsy10.1B2M, TTR
16scott syndrome10.1KRT16, KRT6A, KRT6B
17childhood vagina botryoid rhabdomyosarcoma10.1B2M, TTR
18epidermolysis bullosa simplex-mp10.1KRT16, KRT6A, KRT6B
19anaplastic ganglioglioma10.1B2M, TTR
20sclerosteosis 110.1KRT16, KRT17, KRT6B
21pancreatic vasoactive intestinal peptide producing tumor10.1B2M, TTR
22hypotrichosis 610.1B2M, TTR
23male genital organ stricture10.1TF, TTR
24cataract 15, multiple types10.1KRT16, KRT17, KRT6A
25female infertility of uterine origin10.1TF, TTR
26malignant spindle cell melanoma10.1KRT16, KRT17
27lymphangitis10.0CD4, KRT6A
28solar retinopathy10.0TF, TTR
29retinal arterial macroaneurysm with supravalvular pulmonic stenosis10.0TF, TTR
30ichthyosis histrix, curth-macklin type10.0KRT16, KRT17
31malignant hyperthermia susceptibility 110.0B2M, TF
32sarcoma10.0
33hairy tongue10.0
34squamous cell carcinoma10.0
35spastic entropion10.0TF, TTR
3646 xy gonadal dysgenesis10.0B2M, CD4
37central nervous system origin vertigo10.0B2M, TF
38bladder sarcoma10.0TF, TTR
39pachyonychia congenita 210.0KRT16, KRT17, KRT6A, KRT6B
40oral hairy leukoplakia10.0CD4, TF
41focal epithelial hyperplasia9.9TF, TTR
42sclerosing cholangitis9.9B2M, CD4
43choriodal dystrophy, central areolar 29.9B2M, TF, TTR
44chronic myocardial ischemia9.9B2M, TF, TTR
45inclusion conjunctivitis9.9B2M, CD4
46van maldergem syndrome 29.9B2M, TTR
47papilledema9.8KRT16, KRT17, KRT6A, KRT6B, TTR
48bacteriuria8.8B2M, CD4, KRT16, KRT17, KRT6A, KRT6B

Graphical network of the top 20 diseases related to Median Rhomboid Glossitis:



Diseases related to median rhomboid glossitis

Symptoms & Phenotypes for Median Rhomboid Glossitis

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MGI Mouse Phenotypes related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8B2M, CD4, KRT16, KRT17, KRT6B
2MP:00107718.0B2M, CD4, KRT16, KRT17, KRT6B

Drugs & Therapeutics for Median Rhomboid Glossitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Median Rhomboid Glossitis

Genetic Tests for Median Rhomboid Glossitis

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Anatomical Context for Median Rhomboid Glossitis

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MalaCards organs/tissues related to Median Rhomboid Glossitis:

36
Tongue

Publications for Median Rhomboid Glossitis

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Articles related to Median Rhomboid Glossitis:

(show all 43)
idTitleAuthorsYear
1
Median rhomboid glossitis-developmental or candidal? (26523164)
2015
2
Application of the novel method in the diagnosis and treatment of median rhomboid glossitis Candida-associated. (24966760)
2014
3
Diagnostic discussion. Median rhomboid glossitis (MRG). (24579425)
2013
4
Median rhomboid glossitis: a clinical and microbiological study. (21912494)
2011
5
Median rhomboid glossitis. (21446620)
2011
6
The prevalence of median rhomboid glossitis in diabetic patients: a case-control study. (22737518)
2011
7
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. (20339702)
2010
8
A classic case of median rhomboid glossitis. (19601454)
2009
9
Median rhomboid glossitis. (17990677)
2007
10
Partial atrophic tongue other than median rhomboid glossitis. (17441970)
2007
11
Pachyonychia congenita associated with median rhomboid glossitis. (17511954)
2007
12
Diagnostic quiz. Case No. 1: median rhomboid glossitis. (17632961)
2006
13
Kaposi's sarcoma of the tongue associated with median rhomboid glossitis in a non-AIDS patient. A case report. (15274372)
2004
14
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. (15316160)
2004
15
A case of median rhomboid glossitis. (12773811)
2003
16
Oral pathology quiz #2. Median rhomboid glossitis. (11808366)
2001
17
Cause of median rhomboid glossitis. (8705579)
1996
18
Median rhomboid glossitis. (8899768)
1996
19
Median rhomboid glossitis and a "kissing" lesion of the palate. (8936507)
1996
20
Median rhomboid glossitis. An oral manifestation in patients infected with HIV. (8078660)
1994
21
Squamous cell carcinoma mimicking median rhomboid glossitis region: report of a case. (8509924)
1993
22
Quantitative evaluation of Langerhans cells in median rhomboid glossitis. (1593492)
1992
23
Median rhomboid glossitis: secondary to colonisation of the tongue by Actinomyces (a case report). (1841980)
1991
24
Median rhomboid glossitis: review of a puzzling entity. (2097050)
1990
25
Candida albicans in median rhomboid glossitis. A postmortem study. (3088163)
1986
26
Median rhomboid glossitis. A follow-up study of 16 patients. (3459824)
1986
27
Median rhomboid glossitis in an infant. Report of a case. (3861810)
1985
28
Tobacco smoking and denture wearing as local aetiological factors in median rhomboid glossitis. (6438002)
1984
29
Chronic candidiasis of the rat tongue: a possible model for human median rhomboid glossitis. (6958728)
1982
30
Median rhomboid glossitis caused by Candida? (282562)
1979
31
Median rhomboid glossitis associated with amyloid deposition. (676752)
1978
32
Median rhomboid glossitis: not a misnomer. Review of the literature and histologic study of twenty-eight cases. (366496)
1978
33
Carcinoma arising in the area of median rhomboid glossitis. (1063965)
1976
34
Median rhomboid glossitis. Candidiasis and not a developmental anomaly. (1201190)
1975
35
Median rhomboid glossitis. Case report. (4713826)
1973
36
Median rhomboid glossitis: a developmental anomaly? (5275506)
1971
37
Prevalence of geographic tongue, fissured tongue, median rhomboid glossitis, and hairy tongue among 3,611 Minnesota schoolchildren. (5270895)
1970
38
Median rhomboid glossitis. Case report. (5353692)
1969
39
Incidence of geographic tongue and median rhomboid glossitis in 3,319 Negro college students. (5245682)
1968
40
Median rhomboid glossitis: an atypical variant. (5234276)
1967
41
Median rhomboid glossitis; case reported in an infant. (13125261)
1954
42
The occurrence of Fordyce spots, benign migratory glossitis, median rhomboid glossitis, and fissured tongue in 2,478 dental patients. (13088005)
1953
43
Median rhomboid glossitis; report of a case. (13013723)
1952

Variations for Median Rhomboid Glossitis

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Expression for genes affiliated with Median Rhomboid Glossitis

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Search GEO for disease gene expression data for Median Rhomboid Glossitis.

Pathways for genes affiliated with Median Rhomboid Glossitis

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Pathways related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.4KRT17, KRT6A, KRT6B
2
Show member pathways
9.3KRT16, KRT17, KRT6A
3
Show member pathways
9.0KRT16, KRT17, KRT6A, KRT6B

GO Terms for genes affiliated with Median Rhomboid Glossitis

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Cellular components related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1HFE-transferrin receptor complexGO:19907129.9B2M, TF
2clathrin-coated vesicle membraneGO:00306659.8CD4, TF
3endoplasmic reticulum lumenGO:00057889.3B2M, CD4, TF
4intermediate filamentGO:00058829.0KRT16, KRT17, KRT6A, KRT6B
5extracellular exosomeGO:00700628.0B2M, KRT16, KRT17, KRT6A, KRT6B, TF

Biological processes related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeleton organizationGO:004510410.3KRT16, KRT6A
2cytoskeleton organizationGO:000701010.0KRT16, KRT6A, KRT6B
3cellular response to iron ionGO:007128110.0B2M, TF
4iron ion homeostasisGO:005507210.0B2M, TF
5iron ion transportGO:00068269.9B2M, TF
6positive regulation of receptor-mediated endocytosisGO:00482609.8B2M, TF
7defense response to Gram-negative bacteriumGO:00508299.8B2M, CD4
8cornificationGO:00702689.7KRT16, KRT17, KRT6A, KRT6B
9regulation of defense response to virus by virusGO:00506909.6B2M, CD4
10cellular protein metabolic processGO:00442679.6B2M, TF, TTR
11keratinizationGO:00314249.5KRT16, KRT17, KRT6A, KRT6B
12retina homeostasisGO:00018959.3B2M, TF

Molecular functions related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein bindingGO:004228910.1CD4, KRT17
2glycoprotein bindingGO:000194810.0B2M, CD4
3structural constituent of cytoskeletonGO:00052009.6KRT16, KRT17, KRT6A, KRT6B
4structural molecule activityGO:00051989.3KRT16, KRT17, KRT6A
5protein bindingGO:00055156.7B2M, CD4, KRT16, KRT17, KRT6A, KRT6B

Sources for Median Rhomboid Glossitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet