MCID: MDS006
MIFTS: 31

Mediastinal Gray Zone Lymphoma malady

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Mediastinal Gray Zone Lymphoma

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Aliases & Descriptions for Mediastinal Gray Zone Lymphoma:

Name: Mediastinal Gray Zone Lymphoma 11 13
 
Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma 68

Classifications:



External Ids:

Disease Ontology11 DOID:6867
NCIt45 C37870

Summaries for Mediastinal Gray Zone Lymphoma

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MalaCards based summary: Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to lymphoma and gray zone lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is PAX5 (Paired Box 5), and among its related pathways are Signaling events mediated by HDAC Class II and Transcriptional misregulation in cancer. Affiliated tissues include b cells, and related mouse phenotypes are Decreased substrate adherent cell growth and Increased cell death HMECs cells.

Related Diseases for Mediastinal Gray Zone Lymphoma

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Diseases related to Mediastinal Gray Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma10.4
2gray zone lymphoma10.4
3mediastinitis10.4
4b-cell lymphomas10.3
5uterine ligament endometrioid adenocarcinoma10.2BCL11A, PAX5
6hinman syndrome10.2PAX5, REL
7primary mediastinal large b-cell lymphoma10.2
8abcc4-related altered drug metabolism10.1BCL11A, REL, XPO1
9hodgkin lymphoma10.1
10fallopian tube endometrioid adenocarcinoma10.1BCL11A, CD274, PAX5, SLC22A2
11asthma-related traits 310.1BCL11A, REL, XPO1
12paranasal sinus cancer10.1PAX5, TNFRSF8
13nutritional deficiency disease10.0FUT4, TNFRSF8
14presynaptic congenital myasthenic syndromes10.0BCL6, CD274, JAK2
15subacute delirium10.0FUT4, PAX5, TNFRSF8
16thyroid cancer, nonmedullary, 410.0CD274, JAK2, PDCD1LG2
17teebi naguib al awadi syndrome10.0BCL6, SLC22A2, TNFRSF8
18basal ganglia disease9.9BCL6, PAX5, TNFRSF8
19lip cancer9.9BCL6, PAX5, TNFRSF8
20penile disease9.9BCL6, TNFRSF8
21hemophagocytic lymphohistiocytosis9.9JAK2, PAX5, TNFRSF8
22spinal cord intramedullary teratoma9.9BCL6, FUT4, TNFRSF8
23fallopian tube leiomyoma9.9FUT4, TNFRSF8
24ectodermal dysplasia9.8BCL6, PAX5, REL, TNFRSF8
25bladder disease9.8BCL6, PAX5, REL, TNFRSF8
26carnitine-acylcarnitine translocase deficiency9.8BCL6, PAX5, REL, TNFRSF8
27marantic endocarditis9.7BCL11A, BCL6, PAX5, REL, TNFRSF8
28ureter transitional cell carcinoma8.3BCL11A, BCL6, CD274, DAPK1, EPHA7, FUT4
29ureter small cell carcinoma8.2BCL11A, BCL6, CD274, DAPK1, EPHA7, FUT4

Graphical network of the top 20 diseases related to Mediastinal Gray Zone Lymphoma:



Diseases related to mediastinal gray zone lymphoma

Symptoms & Phenotypes for Mediastinal Gray Zone Lymphoma

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GenomeRNAi Phenotypes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00193-A-310.3DAPK1, EPHA7, JAK2
2GR00103-A-08.6BCL6, DAPK1, EPHA7, JAK2, XPO1

MGI Mouse Phenotypes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1BCL11A, BCL6, CD274, DAPK1, FUT4, HOXA5
2MP:00053976.4BCL11A, BCL6, CD274, FUT4, GPR15, HOXA5
3MP:00053876.3BCL11A, BCL6, CD274, FUT4, GPR15, HOXA5

Drugs & Therapeutics for Mediastinal Gray Zone Lymphoma

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Drugs for Mediastinal Gray Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
nivolumabapprovedPhase 1, Phase 2424946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
2
rituximabapprovedPhase 21692174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
3ImmunoglobulinsPhase 1, Phase 26394
4Antineoplastic Agents, AlkylatingPhase 2, Phase 14603
5AntibodiesPhase 1, Phase 26394
6Alkylating AgentsPhase 2, Phase 14827
7Antirheumatic AgentsPhase 2, Phase 110956
8Antibodies, MonoclonalPhase 1, Phase 24039
9
FludarabineapprovedPhase 1115421679-14-1, 75607-67-930751
Synonyms:
(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
2-F-ARAA
2-F-ara-A
2-Fluoro Ara-A
2-Fluoro-9-beta-D-arabinofuranosyladenine
2-fluoro ARA-A
21679-14-1
9-beta-D-Arabinofuranosyl-2-fluoroadenine
9-beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine
9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- (9CI)
AC1LCW8I
AC1Q51CF
C10H12FN5O4
CCRIS 3382
CHEMBL1568
CID657237
CPD000058874
D07966
EINECS 244-525-5
F-Ara-A
FAMP
FT-0082766
FaraA
Fludara
Fludara, Fludarabine
 
Fludarabina
Fludarabina [Spanish]
Fludarabine
Fludarabine (INN)
Fludarabine 5'-monophosphate
Fludarabine [INN]
Fludarabine monophosphate
Fludarabine phosphate
Fludarabinum
Fludarabinum [Latin]
Fludura
Fluradosa
Fluradosa (TN)
HSDB 6964
I14-4978
LS-15061
MLS000028687
NSC 118218
NSC 118218H
NSC-118218
S1491_Selleck
SAM002548956
SMR000058874
SQ Fludarabine
UNII-1X9VK9O1SC
UNII-P2K93U8740
ZINC04216238
10
Cyclophosphamideapproved, investigationalPhase 1293550-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Anhydrous cyclophosphamide
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
 
DB00531
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
11Immunosuppressive AgentsPhase 113086

Interventional clinical trials:

idNameStatusNCT IDPhase
1An Investigational Immuno-therapy Safety and Effectiveness Study of Nivolumab in Combination With Brentuximab Vedotin to Treat Non-Hodgkin LymphomasRecruitingNCT02581631Phase 1, Phase 2
2A Phase I/II Study Of Brentuximab Vedotin In Combination With Multi-Agent Chemotherapy As Front-Line Treatment In Patients With CD30 Positive Primary Mediastinal Large B-Cell, Diffuse Large B-Cell, And Grey Zone LymphomasRecruitingNCT01994850Phase 1, Phase 2
3Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's LymphomaRecruitingNCT00001337Phase 2
4Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin LymphomaWithdrawnNCT02623920Phase 2
5T Cells Expressing a Fully-Human Anti-CD30 Chimeric Antigen Receptor for Treating CD30-Expressing LymphomasRecruitingNCT03049449Phase 1
6Mediastinal Grey Zone Lymphoma From the LYSACompletedNCT03037177

Search NIH Clinical Center for Mediastinal Gray Zone Lymphoma

Genetic Tests for Mediastinal Gray Zone Lymphoma

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Anatomical Context for Mediastinal Gray Zone Lymphoma

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MalaCards organs/tissues related to Mediastinal Gray Zone Lymphoma:

36
B cells

Publications for Mediastinal Gray Zone Lymphoma

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Articles related to Mediastinal Gray Zone Lymphoma:

(show all 14)
idTitleAuthorsYear
1
Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association. (27758822)
2017
2
Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? (26957476)
2016
3
Mediastinal Gray Zone Lymphoma with Features Intermediate between Classical Hodgkin Lymphoma and Primary Mediastinal B-Cell Lymphoma. (27623181)
2016
4
Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? (25499450)
2015
5
Mediastinal Gray Zone Lymphoma. (27164737)
2015
6
A prospective study of mediastinal gray-zone lymphoma. (25024303)
2014
7
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. (21454882)
2011
8
Mediastinal gray zone lymphoma. (21454881)
2011
9
Primary mediastinal (thymic) large B-cell lymphoma: a short review with brief discussion of mediastinal gray zone lymphoma. (21366467)
2011
10
Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do? (21590365)
2011
11
Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children. (20971819)
2011
12
Two cases of mediastinal gray zone lymphoma. (21123972)
2010
13
Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. (16224207)
2005
14
Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. (15322489)
2004

Variations for Mediastinal Gray Zone Lymphoma

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Expression for genes affiliated with Mediastinal Gray Zone Lymphoma

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Search GEO for disease gene expression data for Mediastinal Gray Zone Lymphoma.

Pathways for genes affiliated with Mediastinal Gray Zone Lymphoma

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GO Terms for genes affiliated with Mediastinal Gray Zone Lymphoma

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Cellular components related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endomembrane systemGO:00125059.2CD274, JAK2, PDCD1LG2

Biological processes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of activated T cell proliferationGO:004600710.3CD274, PDCD1LG2
2negative regulation of interferon-gamma productionGO:003268910.3CD274, PDCD1LG2
3negative regulation of interleukin-10 productionGO:003269310.3CD274, PDCD1LG2
4negative regulation of transcription from RNA polymerase II promoterGO:00001229.4BCL11A, BCL6, PAX5, REL, XPO1
5positive regulation of apoptotic processGO:00430658.5BCL6, EPHA7, HOXA5, JAK2, TNFRSF8

Sources for Mediastinal Gray Zone Lymphoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet