MCID: MDS006
MIFTS: 31

Mediastinal Gray Zone Lymphoma malady

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Mediastinal Gray Zone Lymphoma

Aliases & Descriptions for Mediastinal Gray Zone Lymphoma:

Name: Mediastinal Gray Zone Lymphoma 12 14
Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:6867
NCIt 47 C37870
UMLS 69 C1334657

Summaries for Mediastinal Gray Zone Lymphoma

MalaCards based summary : Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to lymphoma and gray zone lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is PAX5 (Paired Box 5), and among its related pathways/superpathways are Transcriptional misregulation in cancer and NF-kappaB Signaling. The drugs nivolumab and rituximab have been mentioned in the context of this disorder. Affiliated tissues include b cells, and related phenotypes are Decreased substrate adherent cell growth and cellular

Related Diseases for Mediastinal Gray Zone Lymphoma

Diseases related to Mediastinal Gray Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
id Related Disease Score Top Affiliating Genes
1 lymphoma 10.4
2 gray zone lymphoma 10.4
3 mediastinitis 10.4
4 b-cell lymphomas 10.3
5 uterine ligament endometrioid adenocarcinoma 10.2 BCL11A PAX5
6 hinman syndrome 10.2 PAX5 REL
7 primary mediastinal large b-cell lymphoma 10.2
8 abcc4-related altered drug metabolism 10.1 BCL11A REL XPO1
9 hodgkin lymphoma 10.1
10 fallopian tube endometrioid adenocarcinoma 10.1 BCL11A CD274 PAX5 SLC22A2
11 asthma-related traits 3 10.1 BCL11A REL XPO1
12 paranasal sinus cancer 10.1 PAX5 TNFRSF8
13 nutritional deficiency disease 10.0 FUT4 TNFRSF8
14 presynaptic congenital myasthenic syndromes 10.0 BCL6 CD274 JAK2
15 subacute delirium 10.0 FUT4 PAX5 TNFRSF8
16 thyroid cancer, nonmedullary, 4 10.0 CD274 JAK2 PDCD1LG2
17 teebi naguib al awadi syndrome 10.0 BCL6 SLC22A2 TNFRSF8
18 basal ganglia disease 9.9 BCL6 PAX5 TNFRSF8
19 lip cancer 9.9 BCL6 PAX5 TNFRSF8
20 penile disease 9.9 BCL6 TNFRSF8
21 hemophagocytic lymphohistiocytosis 9.9 JAK2 PAX5 TNFRSF8
22 spinal cord intramedullary teratoma 9.9 BCL6 FUT4 TNFRSF8
23 fallopian tube leiomyoma 9.9 FUT4 TNFRSF8
24 ectodermal dysplasia 9.8 BCL6 PAX5 REL TNFRSF8
25 bladder disease 9.8 BCL6 PAX5 REL TNFRSF8
26 carnitine-acylcarnitine translocase deficiency 9.8 BCL6 PAX5 REL TNFRSF8
27 marantic endocarditis 9.7 BCL11A BCL6 PAX5 REL TNFRSF8
28 ureter transitional cell carcinoma 8.3 BCL11A BCL6 CD274 DAPK1 EPHA7 FUT4
29 ureter small cell carcinoma 8.2 BCL11A BCL6 CD274 DAPK1 EPHA7 FUT4

Graphical network of the top 20 diseases related to Mediastinal Gray Zone Lymphoma:



Diseases related to Mediastinal Gray Zone Lymphoma

Symptoms & Phenotypes for Mediastinal Gray Zone Lymphoma

GenomeRNAi Phenotypes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-2 9.35 DAPK1 EPHA7 JAK2
2 Decreased substrate adherent cell growth GR00193-A-3 9.35 DAPK1 JAK2
3 Increased cell death HMECs cells GR00103-A-0 9.02 BCL6 DAPK1 EPHA7 JAK2 XPO1

MGI Mouse Phenotypes related to Mediastinal Gray Zone Lymphoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.81 CD274 DAPK1 FUT4 HOXA5 JAK2 PAX5
2 hematopoietic system MP:0005397 9.7 BCL11A BCL6 CD274 FUT4 GPR15 HOXA5
3 immune system MP:0005387 9.36 BCL11A BCL6 CD274 FUT4 GPR15 HOXA5

Drugs & Therapeutics for Mediastinal Gray Zone Lymphoma

Drugs for Mediastinal Gray Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 1, Phase 2 946414-94-4
2
rituximab Approved Phase 2 174722-31-7 10201696
3 Antibodies Phase 1, Phase 2
4 Antibodies, Monoclonal Phase 1, Phase 2
5 Immunoglobulins Phase 1, Phase 2
6 Antirheumatic Agents Phase 2,Phase 1
7 Alkylating Agents Phase 2,Phase 1
8 Antineoplastic Agents, Alkylating Phase 2,Phase 1
9
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
10
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
11 Immunosuppressive Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 An Investigational Immuno-therapy Safety and Effectiveness Study of Nivolumab in Combination With Brentuximab Vedotin to Treat Non-Hodgkin Lymphomas Recruiting NCT02581631 Phase 1, Phase 2
2 A Phase I/II Study Of Brentuximab Vedotin In Combination With Multi-Agent Chemotherapy As Front-Line Treatment In Patients With CD30 Positive Primary Mediastinal Large B-Cell, Diffuse Large B-Cell, And Grey Zone Lymphomas Recruiting NCT01994850 Phase 1, Phase 2
3 Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's Lymphoma Recruiting NCT00001337 Phase 2
4 Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma Withdrawn NCT02623920 Phase 2
5 T Cells Expressing a Fully-Human Anti-CD30 Chimeric Antigen Receptor for Treating CD30-Expressing Lymphomas Recruiting NCT03049449 Phase 1
6 Mediastinal Grey Zone Lymphoma From the LYSA Completed NCT03037177

Search NIH Clinical Center for Mediastinal Gray Zone Lymphoma

Genetic Tests for Mediastinal Gray Zone Lymphoma

Anatomical Context for Mediastinal Gray Zone Lymphoma

MalaCards organs/tissues related to Mediastinal Gray Zone Lymphoma:

39
B Cells

Publications for Mediastinal Gray Zone Lymphoma

Articles related to Mediastinal Gray Zone Lymphoma:

(show all 14)
id Title Authors Year
1
Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association. ( 27758822 )
2017
2
Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? ( 26957476 )
2016
3
Mediastinal Gray Zone Lymphoma with Features Intermediate between Classical Hodgkin Lymphoma and Primary Mediastinal B-Cell Lymphoma. ( 27623181 )
2016
4
Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? ( 25499450 )
2015
5
Mediastinal Gray Zone Lymphoma. ( 27164737 )
2015
6
A prospective study of mediastinal gray-zone lymphoma. ( 25024303 )
2014
7
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. ( 21454882 )
2011
8
Mediastinal gray zone lymphoma. ( 21454881 )
2011
9
Primary mediastinal (thymic) large B-cell lymphoma: a short review with brief discussion of mediastinal gray zone lymphoma. ( 21366467 )
2011
10
Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do? ( 21590365 )
2011
11
Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children. ( 20971819 )
2011
12
Two cases of mediastinal gray zone lymphoma. ( 21123972 )
2010
13
Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. ( 16224207 )
2005
14
Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. ( 15322489 )
2004

Variations for Mediastinal Gray Zone Lymphoma

Expression for Mediastinal Gray Zone Lymphoma

Search GEO for disease gene expression data for Mediastinal Gray Zone Lymphoma.

Pathways for Mediastinal Gray Zone Lymphoma

GO Terms for Mediastinal Gray Zone Lymphoma

Cellular components related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endomembrane system GO:0012505 8.8 CD274 JAK2 PDCD1LG2

Biological processes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.65 BCL11A BCL6 PAX5 REL XPO1
2 negative regulation of interferon-gamma production GO:0032689 9.32 CD274 PDCD1LG2
3 negative regulation of interleukin-10 production GO:0032693 9.16 CD274 PDCD1LG2
4 positive regulation of apoptotic process GO:0043065 9.02 BCL6 EPHA7 HOXA5 JAK2 TNFRSF8
5 negative regulation of activated T cell proliferation GO:0046007 8.96 CD274 PDCD1LG2

Sources for Mediastinal Gray Zone Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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