MCID: MDS006
MIFTS: 36

Mediastinal Gray Zone Lymphoma malady

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Mediastinal Gray Zone Lymphoma

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Aliases & Descriptions for Mediastinal Gray Zone Lymphoma:

Name: Mediastinal Gray Zone Lymphoma 10 12
 
Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma 65

Classifications:



External Ids:

Disease Ontology10 DOID:6867
NCIt42 C37870
UMLS65 C1334657

Summaries for Mediastinal Gray Zone Lymphoma

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MalaCards based summary: Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to hodgkin lymphoma and gray zone lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is EPHA7 (EPH Receptor A7), and among its related pathways are Cytokine production by Th17 cells in CF and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Affiliated tissues include b cells, t cells and endothelial, and related mouse phenotypes are endocrine/exocrine gland and cellular.

Related Diseases for Mediastinal Gray Zone Lymphoma

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Diseases related to Mediastinal Gray Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
idRelated DiseaseScoreTop Affiliating Genes
1hodgkin lymphoma28.4BCL6, CSF3, PAX5, REL, TNFRSF8
2gray zone lymphoma11.8
3chromosome 2p16.1-p15 deletion syndrome10.6BCL11A, REL
4lymphoma10.5
5mediastinitis10.5
6t-cell leukemia10.4CD274, PAX5
7b-cell lymphomas10.4
8methotrexate-associated lymphoproliferation10.3BCL11A, PAX2, PAX5
9primary mediastinal large b-cell lymphoma10.3
10t-cell large granular lymphocyte leukemia10.3PAX2, PAX5
11middle ear disease10.2FUT4, TNFRSF8
12pediatric lymphoma10.1BCL11A, CD274, PAX2, PAX5
13swayback10.1FUT4, TNFRSF8
14granulomatous dermatitis10.0FUT4, TNFRSF8
15corticosterone methyloxidase deficiency9.9CSF3, JAK2
16acute liver failure9.8CSF3, JAK2, PAX5
17nervous system disease9.7FUT4, PAX2, PAX5, TNFRSF8
18gastroparesis9.6CSF3, TNFRSF8
19collagen disease9.6BCL6, PAX5, TNFRSF8
20aortic aneurysm9.5BCL6, FUT4, TNFRSF8
21hematopoietic stem cell transplantation9.5CSF3, JAK2, PAX5, TNFRSF8
22dilated cardiomyopathy9.5BCL6, REL, TNFRSF8
23sternum lymphoma9.3BCL6, PAX2, PAX5, TNFRSF8
24gas gangrene9.3BCL6, CSF3, EPHA7, PAX5
25behcet's disease9.3BCL6, PAX5, REL, TNFRSF8
26smoking as a quantitative trait locus 19.0BCL6, CSF3, PAX5, TNFRSF8
27cutaneous t cell lymphoma9.0BCL11A, BCL6, PAX5, REL, TNFRSF8
28cell type cancer9.0BCL6, CSF3, JAK2, TNFRSF8
29cell type benign neoplasm8.4BCL6, CSF3, FUT4, JAK2, PAX5, TNFRSF8
30acute myeloid leukemia with 11q23 abnormalities8.0BCL6, CD274, CSF3, JAK2, PDCD1LG2, REL
31mediastinal malignant lymphoma5.5BCL11A, BCL6, CD274, CSF3, DAPK1, EPHA7
32parasagittal meningioma5.4BCL11A, BCL6, CD274, CSF3, DAPK1, EPHA7

Graphical network of the top 20 diseases related to Mediastinal Gray Zone Lymphoma:



Diseases related to mediastinal gray zone lymphoma

Symptoms for Mediastinal Gray Zone Lymphoma

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Drugs & Therapeutics for Mediastinal Gray Zone Lymphoma

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Drugs for Mediastinal Gray Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 21582174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2Antirheumatic AgentsPhase 28496
3Bendamustine HydrochloridePhase 2248
4Antineoplastic Agents, AlkylatingPhase 23406
5Alkylating AgentsPhase 23582
6Antibodies, MonoclonalPhase 1, Phase 22413
7ImmunoglobulinsPhase 1, Phase 24477
8Immunologic FactorsPhase 1, Phase 218483
9AntibodiesPhase 1, Phase 24477

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Phase I/II Study Of Brentuximab Vedotin In Combination With Multi-Agent Chemotherapy As Front-Line Treatment In Patients With CD30 Positive Primary Mediastinal Large B-Cell, Diffuse Large B-Cell, And Grey Zone LymphomasRecruitingNCT01994850Phase 1, Phase 2
2Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin LymphomaRecruitingNCT02623920Phase 2
3Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's LymphomaRecruitingNCT00001337Phase 2

Search NIH Clinical Center for Mediastinal Gray Zone Lymphoma

Genetic Tests for Mediastinal Gray Zone Lymphoma

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Anatomical Context for Mediastinal Gray Zone Lymphoma

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MalaCards organs/tissues related to Mediastinal Gray Zone Lymphoma:

33
B cells, T cells, Endothelial, Myeloid, Skin, Kidney, Liver

Animal Models for Mediastinal Gray Zone Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Mediastinal Gray Zone Lymphoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.8BCL11A, BCL6, HOXA5, JAK2, PAX2, PDCD1LG2
2MP:00053847.0BCL11A, BCL6, CD274, DAPK1, FUT4, HOXA5
3MP:00107686.4BCL11A, BCL6, CD274, GPR15, HOXA5, JAK2
4MP:00053975.4BCL11A, BCL6, CD274, CSF3, FUT4, GPR15
5MP:00053875.1BCL11A, BCL6, CD274, CSF3, FUT4, GPR15

Publications for Mediastinal Gray Zone Lymphoma

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Articles related to Mediastinal Gray Zone Lymphoma:

(show all 12)
idTitleAuthorsYear
1
Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? (26957476)
2016
2
Mediastinal Gray Zone Lymphoma. (27164737)
2015
3
Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? (25499450)
2015
4
A prospective study of mediastinal gray-zone lymphoma. (25024303)
2014
5
Mediastinal gray zone lymphoma. (21454881)
2011
6
Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do? (21590365)
2011
7
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. (21454882)
2011
8
Primary mediastinal (thymic) large B-cell lymphoma: a short review with brief discussion of mediastinal gray zone lymphoma. (21366467)
2011
9
Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children. (20971819)
2011
10
Two cases of mediastinal gray zone lymphoma. (21123972)
2010
11
Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. (16224207)
2005
12
Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. (15322489)
2004

Variations for Mediastinal Gray Zone Lymphoma

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Expression for genes affiliated with Mediastinal Gray Zone Lymphoma

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Search GEO for disease gene expression data for Mediastinal Gray Zone Lymphoma.

Pathways for genes affiliated with Mediastinal Gray Zone Lymphoma

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GO Terms for genes affiliated with Mediastinal Gray Zone Lymphoma

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Biological processes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of activated T cell proliferationGO:004600710.3CD274, PDCD1LG2
2negative regulation of T cell proliferationGO:004213010.3CD274, PDCD1LG2
3negative regulation of interferon-gamma productionGO:003268910.3CD274, PDCD1LG2
4negative regulation of neuron deathGO:190121510.1CSF3, REL
5positive regulation of transcription from RNA polymerase II promoterGO:00459448.9BCL11A, HOXA5, PAX2, PAX5, REL
6signal transductionGO:00071658.8BCL11A, CD274, DAPK1, JAK2, TNFRSF8
7multicellular organism developmentGO:00072758.6CSF3, PAX2, PAX5, TNFRSF8

Sources for Mediastinal Gray Zone Lymphoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet