Mediastinal Gray Zone Lymphoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Aliases & Classifications for Mediastinal Gray Zone Lymphoma

Sources:
¹¹Disease Ontology, ¹³DISEASES, ⁴⁵NCIt, ⁶⁸UMLS
See all MalaCards sources

Aliases & Descriptions for Mediastinal Gray Zone Lymphoma:

Name: Mediastinal Gray Zone Lymphoma ¹¹ ¹³

Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma ⁶⁸

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology¹¹ DOID:6867

NCIt⁴⁵ C37870

UMLS⁶⁸ C1334657

Summaries for Mediastinal Gray Zone Lymphoma

Sources:
³⁶MalaCards
See all MalaCards sources

MalaCards based summary: Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to lymphoma and gray zone lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is PAX5 (Paired Box 5), and among its related pathways are Signaling events mediated by HDAC Class II and Transcriptional misregulation in cancer. Affiliated tissues include b cells, and related mouse phenotypes are Decreased substrate adherent cell growth and Increased cell death HMECs cells.

Related Diseases for Mediastinal Gray Zone Lymphoma

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases related to Mediastinal Gray Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)

id	Related Disease	Score	Top Affiliating Genes
1	lymphoma	10.4
2	gray zone lymphoma	10.4
3	mediastinitis	10.4
4	b-cell lymphomas	10.3
5	uterine ligament endometrioid adenocarcinoma	10.2	BCL11A, PAX5
6	hinman syndrome	10.2	PAX5, REL
7	primary mediastinal large b-cell lymphoma	10.2
8	abcc4-related altered drug metabolism	10.1	BCL11A, REL, XPO1
9	hodgkin lymphoma	10.1
10	fallopian tube endometrioid adenocarcinoma	10.1	BCL11A, CD274, PAX5, SLC22A2
11	asthma-related traits 3	10.1	BCL11A, REL, XPO1
12	paranasal sinus cancer	10.1	PAX5, TNFRSF8
13	nutritional deficiency disease	10.0	FUT4, TNFRSF8
14	presynaptic congenital myasthenic syndromes	10.0	BCL6, CD274, JAK2
15	subacute delirium	10.0	FUT4, PAX5, TNFRSF8
16	thyroid cancer, nonmedullary, 4	10.0	CD274, JAK2, PDCD1LG2
17	teebi naguib al awadi syndrome	10.0	BCL6, SLC22A2, TNFRSF8
18	basal ganglia disease	9.9	BCL6, PAX5, TNFRSF8
19	lip cancer	9.9	BCL6, PAX5, TNFRSF8
20	penile disease	9.9	BCL6, TNFRSF8
21	hemophagocytic lymphohistiocytosis	9.9	JAK2, PAX5, TNFRSF8
22	spinal cord intramedullary teratoma	9.9	BCL6, FUT4, TNFRSF8
23	fallopian tube leiomyoma	9.9	FUT4, TNFRSF8
24	ectodermal dysplasia	9.8	BCL6, PAX5, REL, TNFRSF8
25	bladder disease	9.8	BCL6, PAX5, REL, TNFRSF8
26	carnitine-acylcarnitine translocase deficiency	9.8	BCL6, PAX5, REL, TNFRSF8
27	marantic endocarditis	9.7	BCL11A, BCL6, PAX5, REL, TNFRSF8
28	ureter transitional cell carcinoma	8.3	BCL11A, BCL6, CD274, DAPK1, EPHA7, FUT4
29	ureter small cell carcinoma	8.2	BCL11A, BCL6, CD274, DAPK1, EPHA7, FUT4

Graphical network of the top 20 diseases related to Mediastinal Gray Zone Lymphoma:

Symptoms & Phenotypes for Mediastinal Gray Zone Lymphoma

Sources:
²⁶GenomeRNAi, ⁴¹MGI
See all MalaCards sources

GenomeRNAi Phenotypes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

²⁶

id	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased substrate adherent cell growth	GR00193-A-3	10.3	DAPK1, EPHA7, JAK2
2	Increased cell death HMECs cells	GR00103-A-0	8.6	BCL6, DAPK1, EPHA7, JAK2, XPO1

MGI Mouse Phenotypes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	8.1	BCL11A, BCL6, CD274, DAPK1, FUT4, HOXA5
2	hematopoietic system	MP:0005397	6.4	BCL11A, BCL6, CD274, FUT4, GPR15, HOXA5
3	immune system	MP:0005387	6.3	BCL11A, BCL6, CD274, FUT4, GPR15, HOXA5

Drugs & Therapeutics for Mediastinal Gray Zone Lymphoma

Sources:
¹BitterDB, ⁴ClinicalTrials, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁵⁰Novoseek, ⁵⁶PharmGKB
See all MalaCards sources

Drugs for Mediastinal Gray Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

nivolumab

approved

Phase 1, Phase 2

424

946414-94-4

Synonyms:

BMS-936558

MDX-1106

ONO-4538

nivolumab

2

rituximab

approved

Phase 2

1692

174722-31-7

10201696

Synonyms:

AntiCD20

IDEC-102

IDEC-C2B8

Ig gamma-1 chain C region

MabThera

Mabthera

Rituxan

rituximab

3

Immunoglobulins

Phase 1, Phase 2

6394

4

Antineoplastic Agents, Alkylating

Phase 2, Phase 1

4603

5

Antibodies

Phase 1, Phase 2

6394

6

Alkylating Agents

Phase 2, Phase 1

4827

7

Antirheumatic Agents

Phase 2, Phase 1

10956

8

Antibodies, Monoclonal

Phase 1, Phase 2

4039

9

Fludarabine

approved

Phase 1

1154

21679-14-1, 75607-67-9

30751

Synonyms:

(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

2-F-ARAA

2-F-ara-A

2-Fluoro Ara-A

2-Fluoro-9-beta-D-arabinofuranosyladenine

2-fluoro ARA-A

21679-14-1

9-beta-D-Arabinofuranosyl-2-fluoroadenine

9-beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine

9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- (9CI)

AC1LCW8I

AC1Q51CF

C10H12FN5O4

CCRIS 3382

CHEMBL1568

CID657237

CPD000058874

D07966

EINECS 244-525-5

F-Ara-A

FAMP

FT-0082766

FaraA

Fludara

Fludara, Fludarabine

Fludarabina

Fludarabina [Spanish]

Fludarabine

Fludarabine (INN)

Fludarabine 5'-monophosphate

Fludarabine [INN]

Fludarabine monophosphate

Fludarabine phosphate

Fludarabinum

Fludarabinum [Latin]

Fludura

Fluradosa

Fluradosa (TN)

HSDB 6964

I14-4978

LS-15061

MLS000028687

NSC 118218

NSC 118218H

NSC-118218

S1491_Selleck

SAM002548956

SMR000058874

SQ Fludarabine

UNII-1X9VK9O1SC

UNII-P2K93U8740

ZINC04216238

10

Cyclophosphamide

approved, investigational

Phase 1

2935

50-18-0, 6055-19-2

2907

Synonyms:

(+-)-Cyclophosphamide

(-)-Cyclophosphamide

(RS)-Cyclophosphamide

1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine

1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin

2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

4-Hydroxy-cyclophosphan-mamophosphatide

50-18-0

60007-95-6

6055-19-2 (monohydrate)

75526-90-8

AC1L1EQQ

AI3-26198

ASTA

ASTA B518

Anhydrous cyclophosphamide

Asta B 518

B 518

B-518

BRN 0011744

BSPBio_002099

Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester

C 0768

C07888

C7H15Cl2N2O2P

CB 4564

CB-4564

CCRIS 188

CHEBI:4027

CHEMBL32520

CHEMBL88

CID2907

CP

CPA

CTX

CY

Ciclofosfamida

Ciclofosfamida [INN-Spanish]

Ciclofosfamide

Ciclophosphamide

Ciclophosphamide [INN]

Clafen

Claphene

Cycloblastin

Cyclophosphamid

Cyclophosphamide

Cyclophosphamide (INN)

Cyclophosphamide (TN)

Cyclophosphamide (anhydrous form)

Cyclophosphamide (anhydrous)

Cyclophosphamide Monohydrate

Cyclophosphamide Sterile

Cyclophosphamide anhydrous

Cyclophosphamide, (+-)-Isomer

Cyclophosphamides

Cyclophosphamidum

Cyclophosphamidum [INN-Latin]

Cyclophosphan

Cyclophosphane

Cyclophosphanum

Cyclophosphoramide

Cyclostin

Cyklofosfamid

Cyklofosfamid [Czech]

Cytophosphan

Cytophosphane

Cytoxan

Cytoxan (TN)

Cytoxan Lyoph

D,L-Cyclophosphamide

D07760

DB00531

DivK1c_000246

EINECS 200-015-4

EU-0100238

Endoxan

Endoxan R

Endoxan-Asta

Endoxana

Endoxanal

Endoxane

Enduxan

Genoxal

HMS2090A12

HSDB 3047

Hexadrin

IDI1_000246

KBio1_000246

KBio2_001338

KBio2_003906

KBio2_006474

KBio3_001319

KBioGR_000888

KBioSS_001338

LS-1302

LS-99787

Ledoxina

Lopac-C-0768

Lopac0_000238

Lyophilized Cytoxan

Mitoxan

MolPort-001-783-420

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

NCGC00015209-01

NCGC00015209-03

NCGC00015209-06

NCGC00091741-02

NCGC00091741-03

NCI-C04900

NCI60_002097

NINDS_000246

NSC 26271

NSC-26271

NSC26271

NSC273033

NSC273034

Neosar

Occupation, cyclophosphamide exposure

Procytox

RCRA waste no. U058

Rcra Waste Number U058

Rcra waste number U058

Revimmune

S1217_Selleck

SK 20501

SPBio_001071

STK177249

STOCK2S-91217

Semdoxan

Sendoxan

Senduxan

Spectrum2_001146

Spectrum3_000370

Spectrum4_000304

Spectrum5_000795

Spectrum_000858

UNII-6UXW23996M

WLN: T6MPOTJ BO BN2G2G

Zyklophosphamid

Zyklophosphamid [German]

bis(2-Chloroethyl)phosphami de cyclic propanolamide

bis(2-Chloroethyl)phosphamide cyclic propanolamide ester

cyclophosphamide

11

Immunosuppressive Agents

Phase 1

13086

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	An Investigational Immuno-therapy Safety and Effectiveness Study of Nivolumab in Combination With Brentuximab Vedotin to Treat Non-Hodgkin Lymphomas	Recruiting	NCT02581631	Phase 1, Phase 2
2	A Phase I/II Study Of Brentuximab Vedotin In Combination With Multi-Agent Chemotherapy As Front-Line Treatment In Patients With CD30 Positive Primary Mediastinal Large B-Cell, Diffuse Large B-Cell, And Grey Zone Lymphomas	Recruiting	NCT01994850	Phase 1, Phase 2
3	Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's Lymphoma	Recruiting	NCT00001337	Phase 2
4	Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma	Withdrawn	NCT02623920	Phase 2
5	T Cells Expressing a Fully-Human Anti-CD30 Chimeric Antigen Receptor for Treating CD30-Expressing Lymphomas	Recruiting	NCT03049449	Phase 1
6	Mediastinal Grey Zone Lymphoma From the LYSA	Completed	NCT03037177

Search NIH Clinical Center for Mediastinal Gray Zone Lymphoma

Genetic Tests for Mediastinal Gray Zone Lymphoma

Anatomical Context for Mediastinal Gray Zone Lymphoma

Sources:
³⁶MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Mediastinal Gray Zone Lymphoma:

³⁶

B cells

Publications for Mediastinal Gray Zone Lymphoma

Sources:
⁵⁷PubMed
See all MalaCards sources

Articles related to Mediastinal Gray Zone Lymphoma:

(show all 14)

id	Title	Authors	Year
1	Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association. (27758822)	Sarkozy C.... Traverse-Glehen A.	2017
2	Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? (26957476)	Verma A.... Banavali S.	2016
3	Mediastinal Gray Zone Lymphoma with Features Intermediate between Classical Hodgkin Lymphoma and Primary Mediastinal B-Cell Lymphoma. (27623181)	Song H.N.... Kim W.S.	2016
4	Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? (25499450)	Dunleavy K.... Wilson W.H.	2015
5	Mediastinal Gray Zone Lymphoma. (27164737)	Bhardwaj M.... Malhotra V.	2015
6	A prospective study of mediastinal gray-zone lymphoma. (25024303)	Wilson W.H.... Dunleavy K.	2014
7	Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. (21454882)	Eberle F.C.... Jaffe E.S.	2011
8	Mediastinal gray zone lymphoma. (21454881)	Quintanilla-Martinez L.... Fend F.	2011
9	Primary mediastinal (thymic) large B-cell lymphoma: a short review with brief discussion of mediastinal gray zone lymphoma. (21366467)	Hutchinson C.B.... Wang E.	2011
10	Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do? (21590365)	Grant C.... Jaffe E.S.	2011
11	Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children. (20971819)	Oschlies I.... Klapper W.	2011
12	Two cases of mediastinal gray zone lymphoma. (21123972)	Minami J.... Usui N.	2010
13	Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. (16224207)	Traverse-Glehen A.... Jaffe E.S.	2005
14	Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. (15322489)	Calvo K.R.... Jaffe E.S.	2004

Genes related to Mediastinal Gray Zone Lymphoma

Sources:
⁸Cosmic, ¹³DISEASES, ²¹GeneCards
See all MalaCards sources

Genes related to Mediastinal Gray Zone Lymphoma:

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	PAX5	Paired Box 5	33.54	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
2	SLC22A2	Solute Carrier Family 22 Member 2	28.87	GeneCards inferred via : Disorders, Publications (show sections)
3	EPHA7	EPH Receptor A7	24.76	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
4	HOXA5	Homeobox A5	24.50	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
5	CD274	CD274 Molecule	24.21	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
6	BCL11A	B-Cell CLL/Lymphoma 11A	24.13	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
7	XPO1	Exportin 1	23.87	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
8	DAPK1	Death Associated Protein Kinase 1	23.69	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
9	REL	REL Proto-Oncogene, NF-KB Subunit	23.37	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
10	JAK2	Janus Kinase 2	22.31	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
11	FUT4	Fucosyltransferase 4	15.26	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
12	TNFRSF8	TNF Receptor Superfamily Member 8	13.99	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
13	PDCD1LG2	Programmed Cell Death 1 Ligand 2	13.83	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
14	GPR15	G Protein-Coupled Receptor 15	13.02	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
15	BCL6	B-Cell CLL/Lymphoma 6	12.84	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)

Variations for Mediastinal Gray Zone Lymphoma

Expression for genes affiliated with Mediastinal Gray Zone Lymphoma

Sources:
¹⁸Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Mediastinal Gray Zone Lymphoma.

Pathways for genes affiliated with Mediastinal Gray Zone Lymphoma

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁹R&D Systems
See all MalaCards sources

Pathways related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Signaling events mediated by HDAC Class II⁴²	9.6	BCL6, XPO1
2	Transcriptional misregulation in cancer³⁴	9.3	BCL6, PAX5, REL
3	B Cell Development Pathways⁵⁹	9.2	BCL6, PAX5, TNFRSF8
4	T Cell Co-Signaling Pathway: Ligand-Receptor Interactions⁵⁹	9.0	CD274, PDCD1LG2, TNFRSF8
5	IgA-Producing B Cells in the Intestine⁵⁹	8.8	BCL6, CD274, PAX5, PDCD1LG2
6	NF-kappaB Signaling³	8.0	BCL6, CD274, JAK2, PAX5, PDCD1LG2, REL

GO Terms for genes affiliated with Mediastinal Gray Zone Lymphoma

Sources:
¹⁹Gene Ontology
See all MalaCards sources

Cellular components related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	endomembrane system	GO:0012505	9.2	CD274, JAK2, PDCD1LG2

Biological processes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of activated T cell proliferation	GO:0046007	10.3	CD274, PDCD1LG2
2	negative regulation of interferon-gamma production	GO:0032689	10.3	CD274, PDCD1LG2
3	negative regulation of interleukin-10 production	GO:0032693	10.3	CD274, PDCD1LG2
4	negative regulation of transcription from RNA polymerase II promoter	GO:0000122	9.4	BCL11A, BCL6, PAX5, REL, XPO1
5	positive regulation of apoptotic process	GO:0043065	8.5	BCL6, EPHA7, HOXA5, JAK2, TNFRSF8