Mediastinal Gray Zone Lymphoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Aliases & Classifications for Mediastinal Gray Zone Lymphoma

Sources:
¹⁰Disease Ontology, ¹²DISEASES, ⁶⁵UMLS, ⁴²NCIt
See all MalaCards sources

Aliases & Descriptions for Mediastinal Gray Zone Lymphoma:

Name: Mediastinal Gray Zone Lymphoma ¹⁰ ¹²

Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma ⁶⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology¹⁰ DOID:6867

NCIt⁴² C37870

UMLS⁶⁵ C1334657

Summaries for Mediastinal Gray Zone Lymphoma

Sources:
³³MalaCards
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MalaCards based summary: Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to hodgkin lymphoma and gray zone lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is EPHA7 (EPH Receptor A7), and among its related pathways are Cytokine production by Th17 cells in CF and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Affiliated tissues include b cells, t cells and endothelial, and related mouse phenotypes are endocrine/exocrine gland and cellular.

Related Diseases for Mediastinal Gray Zone Lymphoma

Sources:
²⁰GeneCards, ¹⁹GeneAnalytics
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Diseases related to Mediastinal Gray Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)

id	Related Disease	Score	Top Affiliating Genes
1	hodgkin lymphoma	28.4	BCL6, CSF3, PAX5, REL, TNFRSF8
2	gray zone lymphoma	11.8
3	chromosome 2p16.1-p15 deletion syndrome	10.6	BCL11A, REL
4	lymphoma	10.5
5	mediastinitis	10.5
6	t-cell leukemia	10.4	CD274, PAX5
7	b-cell lymphomas	10.4
8	methotrexate-associated lymphoproliferation	10.3	BCL11A, PAX2, PAX5
9	primary mediastinal large b-cell lymphoma	10.3
10	t-cell large granular lymphocyte leukemia	10.3	PAX2, PAX5
11	middle ear disease	10.2	FUT4, TNFRSF8
12	pediatric lymphoma	10.1	BCL11A, CD274, PAX2, PAX5
13	swayback	10.1	FUT4, TNFRSF8
14	granulomatous dermatitis	10.0	FUT4, TNFRSF8
15	corticosterone methyloxidase deficiency	9.9	CSF3, JAK2
16	acute liver failure	9.8	CSF3, JAK2, PAX5
17	nervous system disease	9.7	FUT4, PAX2, PAX5, TNFRSF8
18	gastroparesis	9.6	CSF3, TNFRSF8
19	collagen disease	9.6	BCL6, PAX5, TNFRSF8
20	aortic aneurysm	9.5	BCL6, FUT4, TNFRSF8
21	hematopoietic stem cell transplantation	9.5	CSF3, JAK2, PAX5, TNFRSF8
22	dilated cardiomyopathy	9.5	BCL6, REL, TNFRSF8
23	sternum lymphoma	9.3	BCL6, PAX2, PAX5, TNFRSF8
24	gas gangrene	9.3	BCL6, CSF3, EPHA7, PAX5
25	behcet's disease	9.3	BCL6, PAX5, REL, TNFRSF8
26	smoking as a quantitative trait locus 1	9.0	BCL6, CSF3, PAX5, TNFRSF8
27	cutaneous t cell lymphoma	9.0	BCL11A, BCL6, PAX5, REL, TNFRSF8
28	cell type cancer	9.0	BCL6, CSF3, JAK2, TNFRSF8
29	cell type benign neoplasm	8.4	BCL6, CSF3, FUT4, JAK2, PAX5, TNFRSF8
30	acute myeloid leukemia with 11q23 abnormalities	8.0	BCL6, CD274, CSF3, JAK2, PDCD1LG2, REL
31	mediastinal malignant lymphoma	5.5	BCL11A, BCL6, CD274, CSF3, DAPK1, EPHA7
32	parasagittal meningioma	5.4	BCL11A, BCL6, CD274, CSF3, DAPK1, EPHA7

Graphical network of the top 20 diseases related to Mediastinal Gray Zone Lymphoma:

Symptoms for Mediastinal Gray Zone Lymphoma

Drugs & Therapeutics for Mediastinal Gray Zone Lymphoma

Sources:
⁴⁴NIH Clinical Center, ⁴ClinicalTrials, ¹³DrugBank, ²⁶HMDB, ⁹DGIdb, ⁵³PharmGKB, ³⁰IUPHAR, ⁴⁷Novoseek, ¹BitterDB
See all MalaCards sources

Drugs for Mediastinal Gray Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

rituximab

approved

Phase 2

1582

174722-31-7

10201696

Synonyms:

AntiCD20

IDEC-102

IDEC-C2B8

Ig gamma-1 chain C region

MabThera

Mabthera

Rituxan

rituximab

2

Antirheumatic Agents

Phase 2

8496

3

Bendamustine Hydrochloride

Phase 2

248

4

Antineoplastic Agents, Alkylating

Phase 2

3406

5

Alkylating Agents

Phase 2

3582

6

Antibodies, Monoclonal

Phase 1, Phase 2

2413

7

Immunoglobulins

Phase 1, Phase 2

4477

8

Immunologic Factors

Phase 1, Phase 2

18483

9

Antibodies

Phase 1, Phase 2

4477

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	A Phase I/II Study Of Brentuximab Vedotin In Combination With Multi-Agent Chemotherapy As Front-Line Treatment In Patients With CD30 Positive Primary Mediastinal Large B-Cell, Diffuse Large B-Cell, And Grey Zone Lymphomas	Recruiting	NCT01994850	Phase 1, Phase 2
2	Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma	Recruiting	NCT02623920	Phase 2
3	Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's Lymphoma	Recruiting	NCT00001337	Phase 2

Search NIH Clinical Center for Mediastinal Gray Zone Lymphoma

Genetic Tests for Mediastinal Gray Zone Lymphoma

Anatomical Context for Mediastinal Gray Zone Lymphoma

Sources:
³³MalaCards
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MalaCards organs/tissues related to Mediastinal Gray Zone Lymphoma:

³³

B cells, T cells, Endothelial, Myeloid, Skin, Kidney, Liver

Animal Models for Mediastinal Gray Zone Lymphoma or affiliated genes

Sources:
³⁸MGI
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MGI Mouse Phenotypes related to Mediastinal Gray Zone Lymphoma:

³⁸

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	7.8	BCL11A, BCL6, HOXA5, JAK2, PAX2, PDCD1LG2
2	cellular	MP:0005384	7.0	BCL11A, BCL6, CD274, DAPK1, FUT4, HOXA5
3	mortality/aging	MP:0010768	6.4	BCL11A, BCL6, CD274, GPR15, HOXA5, JAK2
4	hematopoietic system	MP:0005397	5.4	BCL11A, BCL6, CD274, CSF3, FUT4, GPR15
5	immune system	MP:0005387	5.1	BCL11A, BCL6, CD274, CSF3, FUT4, GPR15

Publications for Mediastinal Gray Zone Lymphoma

Sources:
⁵⁴PubMed
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Articles related to Mediastinal Gray Zone Lymphoma:

(show all 12)

id	Title	Authors	Year
1	Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? (26957476)	Verma A.... Banavali S.	2016
2	Mediastinal Gray Zone Lymphoma. (27164737)	Bhardwaj M.... Malhotra V.	2015
3	Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? (25499450)	Dunleavy K.... Wilson W.H.	2015
4	A prospective study of mediastinal gray-zone lymphoma. (25024303)	Wilson W.H.... Dunleavy K.	2014
5	Mediastinal gray zone lymphoma. (21454881)	Quintanilla-Martinez L.... Fend F.	2011
6	Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do? (21590365)	Grant C.... Jaffe E.S.	2011
7	Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. (21454882)	Eberle F.C.... Jaffe E.S.	2011
8	Primary mediastinal (thymic) large B-cell lymphoma: a short review with brief discussion of mediastinal gray zone lymphoma. (21366467)	Hutchinson C.B.... Wang E.	2011
9	Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children. (20971819)	Oschlies I.... Klapper W.	2011
10	Two cases of mediastinal gray zone lymphoma. (21123972)	Minami J.... Usui N.	2010
11	Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. (16224207)	Traverse-Glehen A.... Jaffe E.S.	2005
12	Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. (15322489)	Calvo K.R.... Jaffe E.S.	2004

Genes related to Mediastinal Gray Zone Lymphoma

Sources:
²⁰GeneCards, ¹²DISEASES, ⁷Cosmic
See all MalaCards sources

Genes related to Mediastinal Gray Zone Lymphoma:

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	EPHA7	EPH Receptor A7	16.15	DISEASES inferred ¹²
2	HOXA5	Homeobox A5	15.91	DISEASES inferred ¹²
3	BCL11A	B-Cell CLL/Lymphoma 11A	15.54	DISEASES inferred ¹²
4	CD274	CD274 Molecule	15.32	DISEASES inferred ¹²
5	PAX5	Paired Box 5	15.17	DISEASES inferred ¹²
6	DAPK1	Death Associated Protein Kinase 1	15.08	DISEASES inferred ¹²
7	PAX2	Paired Box 2	14.93	DISEASES inferred ¹²
8	REL	REL Proto-Oncogene, NF-KB Subunit	14.73	DISEASES inferred ¹²
9	JAK2	Janus Kinase 2	13.64	DISEASES inferred ¹²
10	FUT4	Fucosyltransferase 4	5.97	DISEASES inferred ¹²
11	TNFRSF8	Tumor Necrosis Factor Receptor Superfamily Member 8	5.36	DISEASES inferred ¹²
12	PDCD1LG2	Programmed Cell Death 1 Ligand 2	5.36	DISEASES inferred ¹²
13	GPR15	G Protein-Coupled Receptor 15	4.41	DISEASES inferred ¹²
14	BCL6	B-Cell CLL/Lymphoma 6	4.21	DISEASES inferred ¹²
15	CSF3	Colony Stimulating Factor 3	3.47	DISEASES inferred ¹²

Variations for Mediastinal Gray Zone Lymphoma

Expression for genes affiliated with Mediastinal Gray Zone Lymphoma

Sources:
¹⁷Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Mediastinal Gray Zone Lymphoma.

Pathways for genes affiliated with Mediastinal Gray Zone Lymphoma

Sources:
⁵²PathCards, ⁶²Thomson Reuters, ⁵⁷Reactome, ⁵⁶R&D Systems, ³¹KEGG
See all MalaCards sources

Pathways related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Cytokine production by Th17 cells in CF⁶² Show member pathways Cytokine production by Th17 cells in CF (Mouse model)⁶² Transfer of LPS from LBP carrier to CD14⁵⁷	9.2	CSF3, JAK2, REL
2	T Cell Co-Signaling Pathway: Ligand-Receptor Interactions⁵⁶	9.2	CD274, PDCD1LG2, TNFRSF8
3	Transcriptional misregulation in cancer³¹	9.0	BCL6, PAX5, REL
4	B Cell Development Pathways⁵⁶	8.9	BCL6, PAX5, TNFRSF8
5	IgA-Producing B Cells in the Intestine⁵⁶	8.6	BCL6, CD274, PAX5, PDCD1LG2

GO Terms for genes affiliated with Mediastinal Gray Zone Lymphoma

Sources:
¹⁸Gene Ontology
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Biological processes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of activated T cell proliferation	GO:0046007	10.3	CD274, PDCD1LG2
2	negative regulation of T cell proliferation	GO:0042130	10.3	CD274, PDCD1LG2
3	negative regulation of interferon-gamma production	GO:0032689	10.3	CD274, PDCD1LG2
4	negative regulation of neuron death	GO:1901215	10.1	CSF3, REL
5	positive regulation of transcription from RNA polymerase II promoter	GO:0045944	8.9	BCL11A, HOXA5, PAX2, PAX5, REL
6	signal transduction	GO:0007165	8.8	BCL11A, CD274, DAPK1, JAK2, TNFRSF8
7	multicellular organism development	GO:0007275	8.6	CSF3, PAX2, PAX5, TNFRSF8