Mediastinal Gray Zone Lymphoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Aliases & Classifications for Mediastinal Gray Zone Lymphoma

Sources:
¹¹Disease Ontology, ¹³DISEASES, ⁴⁵NCIt, ⁶⁸UMLS
See all MalaCards sources

Aliases & Descriptions for Mediastinal Gray Zone Lymphoma:

Name: Mediastinal Gray Zone Lymphoma ¹¹ ¹³

Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma ⁶⁸

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology¹¹ DOID:6867

NCIt⁴⁵ C37870

UMLS⁶⁸ C1334657

Summaries for Mediastinal Gray Zone Lymphoma

Sources:
³⁶MalaCards
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MalaCards based summary: Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to gray zone lymphoma and hodgkin lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is PAX5 (Paired Box 5), and among its related pathways are Signaling events mediated by HDAC Class II and Transcriptional misregulation in cancer. Affiliated tissues include b cells, and related mouse phenotypes are Decreased substrate adherent cell growth and Increased cell death HMECs cells.

Related Diseases for Mediastinal Gray Zone Lymphoma

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases related to Mediastinal Gray Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)

id	Related Disease	Score	Top Affiliating Genes
1	gray zone lymphoma	31.2	BCL11A, PAX5
2	hodgkin lymphoma	29.4	BCL6, PAX5, REL, TNFRSF8
3	lymphoma	10.4
4	mediastinitis	10.4
5	b-cell lymphomas	10.3
6	malignant sertoli-leydig cell tumor	10.2	PAX5, TNFRSF8
7	primary mediastinal large b-cell lymphoma	10.2
8	chromosome 2p16.1-p15 deletion syndrome	10.2	BCL11A, REL, XPO1
9	adult lymphoma	10.1	BCL11A, CD274, PAX5, SLC22A2
10	idiopathic neutropenia	10.1	BCL6, PAX5
11	auricular cancer	10.0	FUT4, TNFRSF8
12	breast lymphoma	10.0	DAPK1, TNFRSF8
13	nutritional deficiency disease	9.9	FUT4, TNFRSF8
14	upper lip cancer	9.9	FUT4, PAX5, TNFRSF8
15	teebi kaurah syndrome	9.8	BCL6, SLC22A2, TNFRSF8
16	polyembryoma of the ovary	9.8	BCL6, PAX5, TNFRSF8
17	chronic inflammatory demyelinating polyneuritis	9.7	BCL6, TNFRSF8
18	drug-induced hepatitis	9.7	BCL6, REL, TNFRSF8
19	congenital myasthenic syndrome	9.6	BCL6, FUT4, TNFRSF8
20	minimally differentiated acute myeloblastic leukemia	9.6	BCL6, CD274, JAK2, REL
21	bipolar disorder	9.5	BCL6, PAX5, REL, TNFRSF8
22	smoking as a quantitative trait locus 1	9.4	BCL6, PAX5, TNFRSF8
23	hemolytic anemia	9.1	BCL6, FUT4, JAK2, PAX5, TNFRSF8
24	organ system benign neoplasm	9.1	BCL6, FUT4, JAK2, PAX5, TNFRSF8
25	hepatoblastoma	6.0	BCL11A, BCL6, CD274, DAPK1, EPHA7, FUT4
26	parasagittal meningioma	5.8	BCL11A, BCL6, CD274, DAPK1, EPHA7, FUT4

Graphical network of the top 20 diseases related to Mediastinal Gray Zone Lymphoma:

Symptoms & Phenotypes for Mediastinal Gray Zone Lymphoma

Sources:
²⁶GenomeRNAi, ⁴¹MGI
See all MalaCards sources

GenomeRNAi Phenotypes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

²⁶

id	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased substrate adherent cell growth	GR00193-A-3	10.3	DAPK1, EPHA7, JAK2
2	Increased cell death HMECs cells	GR00103-A-0	8.6	BCL6, DAPK1, EPHA7, JAK2, XPO1

MGI Mouse Phenotypes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	8.1	BCL11A, BCL6, CD274, DAPK1, FUT4, HOXA5
2	hematopoietic system	MP:0005397	6.4	BCL11A, BCL6, CD274, FUT4, GPR15, HOXA5
3	immune system	MP:0005387	6.3	BCL11A, BCL6, CD274, FUT4, GPR15, HOXA5

Drugs & Therapeutics for Mediastinal Gray Zone Lymphoma

Sources:
¹BitterDB, ⁴ClinicalTrials, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁵⁰Novoseek, ⁵⁶PharmGKB
See all MalaCards sources

Drugs for Mediastinal Gray Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

rituximab

approved

Phase 2

1654

174722-31-7

10201696

Synonyms:

AntiCD20

IDEC-102

IDEC-C2B8

Ig gamma-1 chain C region

MabThera

Mabthera

Rituxan

rituximab

2

Antirheumatic Agents

Phase 2

10627

3

Bendamustine Hydrochloride

Phase 2

260

4

Antineoplastic Agents, Alkylating

Phase 2

4474

5

Alkylating Agents

Phase 2

4694

6

Antibodies, Monoclonal

Phase 1, Phase 2

3795

7

Immunoglobulins

Phase 1, Phase 2

6045

8

Antibodies

Phase 1, Phase 2

6045

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	A Phase I/II Study Of Brentuximab Vedotin In Combination With Multi-Agent Chemotherapy As Front-Line Treatment In Patients With CD30 Positive Primary Mediastinal Large B-Cell, Diffuse Large B-Cell, And Grey Zone Lymphomas	Recruiting	NCT01994850	Phase 1, Phase 2
2	Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma	Recruiting	NCT02623920	Phase 2
3	Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's Lymphoma	Suspended	NCT00001337	Phase 2

Search NIH Clinical Center for Mediastinal Gray Zone Lymphoma

Genetic Tests for Mediastinal Gray Zone Lymphoma

Anatomical Context for Mediastinal Gray Zone Lymphoma

Sources:
³⁶MalaCards
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MalaCards organs/tissues related to Mediastinal Gray Zone Lymphoma:

³⁶

B cells

Publications for Mediastinal Gray Zone Lymphoma

Sources:
⁵⁷PubMed
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Articles related to Mediastinal Gray Zone Lymphoma:

(show all 14)

id	Title	Authors	Year
1	Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association. (27758822)	Sarkozy C.... Traverse-Glehen A.	2017
2	Mediastinal Gray Zone Lymphoma with Features Intermediate between Classical Hodgkin Lymphoma and Primary Mediastinal B-Cell Lymphoma. (27623181)	Song H.N.... Kim W.S.	2016
3	Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? (26957476)	Verma A.... Banavali S.	2016
4	Mediastinal Gray Zone Lymphoma. (27164737)	Bhardwaj M.... Malhotra V.	2015
5	Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? (25499450)	Dunleavy K.... Wilson W.H.	2015
6	A prospective study of mediastinal gray-zone lymphoma. (25024303)	Wilson W.H.... Dunleavy K.	2014
7	Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do? (21590365)	Grant C.... Jaffe E.S.	2011
8	Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. (21454882)	Eberle F.C.... Jaffe E.S.	2011
9	Primary mediastinal (thymic) large B-cell lymphoma: a short review with brief discussion of mediastinal gray zone lymphoma. (21366467)	Hutchinson C.B.... Wang E.	2011
10	Mediastinal gray zone lymphoma. (21454881)	Quintanilla-Martinez L.... Fend F.	2011
11	Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children. (20971819)	Oschlies I.... Klapper W.	2011
12	Two cases of mediastinal gray zone lymphoma. (21123972)	Minami J.... Usui N.	2010
13	Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. (16224207)	Traverse-Glehen A.... Jaffe E.S.	2005
14	Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. (15322489)	Calvo K.R.... Jaffe E.S.	2004

Genes related to Mediastinal Gray Zone Lymphoma

Sources:
⁸Cosmic, ¹³DISEASES, ²¹GeneCards
See all MalaCards sources

Genes related to Mediastinal Gray Zone Lymphoma:

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	PAX5	Paired Box 5	23.03	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
2	SLC22A2	Solute Carrier Family 22 Member 2	18.31	GeneCards inferred via : Publications (show sections)
3	EPHA7	EPH Receptor A7	15.72	DISEASES inferred ¹³
4	HOXA5	Homeobox A5	15.48	DISEASES inferred ¹³
5	CD274	CD274 Molecule	15.26	DISEASES inferred ¹³
6	BCL11A	B-Cell CLL/Lymphoma 11A	15.10	DISEASES inferred ¹³
7	XPO1	Exportin 1	14.85	DISEASES inferred ¹³
8	DAPK1	Death Associated Protein Kinase 1	14.67	DISEASES inferred ¹³
9	REL	REL Proto-Oncogene, NF-KB Subunit	14.33	DISEASES inferred ¹³
10	JAK2	Janus Kinase 2	13.26	DISEASES inferred ¹³
11	FUT4	Fucosyltransferase 4	6.21	DISEASES inferred ¹³
12	TNFRSF8	TNF Receptor Superfamily Member 8	4.96	DISEASES inferred ¹³
13	PDCD1LG2	Programmed Cell Death 1 Ligand 2	4.84	DISEASES inferred ¹³
14	GPR15	G Protein-Coupled Receptor 15	4.00	DISEASES inferred ¹³
15	BCL6	B-Cell CLL/Lymphoma 6	3.81	DISEASES inferred ¹³

Variations for Mediastinal Gray Zone Lymphoma

Expression for genes affiliated with Mediastinal Gray Zone Lymphoma

Sources:
¹⁸Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Mediastinal Gray Zone Lymphoma.

Pathways for genes affiliated with Mediastinal Gray Zone Lymphoma

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁹R&D Systems
See all MalaCards sources

Pathways related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Signaling events mediated by HDAC Class II⁴²	9.6	BCL6, XPO1
2	Transcriptional misregulation in cancer³⁴	9.3	BCL6, PAX5, REL
3	B Cell Development Pathways⁵⁹	9.2	BCL6, PAX5, TNFRSF8
4	T Cell Co-Signaling Pathway: Ligand-Receptor Interactions⁵⁹	9.0	CD274, PDCD1LG2, TNFRSF8
5	IgA-Producing B Cells in the Intestine⁵⁹	8.8	BCL6, CD274, PAX5, PDCD1LG2
6	NF-kappaB Signaling³	8.0	BCL6, CD274, JAK2, PAX5, PDCD1LG2, REL

GO Terms for genes affiliated with Mediastinal Gray Zone Lymphoma

Sources:
¹⁹Gene Ontology
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Biological processes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of activated T cell proliferation	GO:0046007	10.3	CD274, PDCD1LG2
2	negative regulation of interferon-gamma production	GO:0032689	10.3	CD274, PDCD1LG2
3	negative regulation of interleukin-10 production	GO:0032693	10.3	CD274, PDCD1LG2
4	negative regulation of T cell proliferation	GO:0042130	10.3	CD274, PDCD1LG2
5	negative regulation of transcription from RNA polymerase II promoter	GO:0000122	9.3	BCL11A, BCL6, PAX5, REL, XPO1
6	positive regulation of apoptotic process	GO:0043065	8.5	BCL6, EPHA7, HOXA5, JAK2, TNFRSF8