MCID: MDS006
MIFTS: 30

Mediastinal Gray Zone Lymphoma malady

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Mediastinal Gray Zone Lymphoma

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Aliases & Descriptions for Mediastinal Gray Zone Lymphoma:

Name: Mediastinal Gray Zone Lymphoma 11 13
 
Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma 68

Classifications:



External Ids:

Disease Ontology11 DOID:6867
NCIt45 C37870

Summaries for Mediastinal Gray Zone Lymphoma

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MalaCards based summary: Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to gray zone lymphoma and hodgkin lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is PAX5 (Paired Box 5), and among its related pathways are Signaling events mediated by HDAC Class II and Transcriptional misregulation in cancer. Affiliated tissues include b cells, and related mouse phenotypes are Decreased substrate adherent cell growth and Increased cell death HMECs cells.

Related Diseases for Mediastinal Gray Zone Lymphoma

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Graphical network of the top 20 diseases related to Mediastinal Gray Zone Lymphoma:



Diseases related to mediastinal gray zone lymphoma

Symptoms & Phenotypes for Mediastinal Gray Zone Lymphoma

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GenomeRNAi Phenotypes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00193-A-310.3DAPK1, EPHA7, JAK2
2GR00103-A-08.6BCL6, DAPK1, EPHA7, JAK2, XPO1

MGI Mouse Phenotypes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1BCL11A, BCL6, CD274, DAPK1, FUT4, HOXA5
2MP:00053976.4BCL11A, BCL6, CD274, FUT4, GPR15, HOXA5
3MP:00053876.3BCL11A, BCL6, CD274, FUT4, GPR15, HOXA5

Drugs & Therapeutics for Mediastinal Gray Zone Lymphoma

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Drugs for Mediastinal Gray Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 21654174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2Antirheumatic AgentsPhase 210627
3Bendamustine HydrochloridePhase 2260
4Antineoplastic Agents, AlkylatingPhase 24474
5Alkylating AgentsPhase 24694
6Antibodies, MonoclonalPhase 1, Phase 23795
7ImmunoglobulinsPhase 1, Phase 26045
8AntibodiesPhase 1, Phase 26045

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Phase I/II Study Of Brentuximab Vedotin In Combination With Multi-Agent Chemotherapy As Front-Line Treatment In Patients With CD30 Positive Primary Mediastinal Large B-Cell, Diffuse Large B-Cell, And Grey Zone LymphomasRecruitingNCT01994850Phase 1, Phase 2
2Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin LymphomaRecruitingNCT02623920Phase 2
3Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's LymphomaSuspendedNCT00001337Phase 2

Search NIH Clinical Center for Mediastinal Gray Zone Lymphoma

Genetic Tests for Mediastinal Gray Zone Lymphoma

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Anatomical Context for Mediastinal Gray Zone Lymphoma

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MalaCards organs/tissues related to Mediastinal Gray Zone Lymphoma:

36
B cells

Publications for Mediastinal Gray Zone Lymphoma

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Articles related to Mediastinal Gray Zone Lymphoma:

(show all 14)
idTitleAuthorsYear
1
Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association. (27758822)
2017
2
Mediastinal Gray Zone Lymphoma with Features Intermediate between Classical Hodgkin Lymphoma and Primary Mediastinal B-Cell Lymphoma. (27623181)
2016
3
Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? (26957476)
2016
4
Mediastinal Gray Zone Lymphoma. (27164737)
2015
5
Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? (25499450)
2015
6
A prospective study of mediastinal gray-zone lymphoma. (25024303)
2014
7
Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do? (21590365)
2011
8
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. (21454882)
2011
9
Primary mediastinal (thymic) large B-cell lymphoma: a short review with brief discussion of mediastinal gray zone lymphoma. (21366467)
2011
10
Mediastinal gray zone lymphoma. (21454881)
2011
11
Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children. (20971819)
2011
12
Two cases of mediastinal gray zone lymphoma. (21123972)
2010
13
Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. (16224207)
2005
14
Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. (15322489)
2004

Variations for Mediastinal Gray Zone Lymphoma

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Expression for genes affiliated with Mediastinal Gray Zone Lymphoma

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Search GEO for disease gene expression data for Mediastinal Gray Zone Lymphoma.

Pathways for genes affiliated with Mediastinal Gray Zone Lymphoma

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GO Terms for genes affiliated with Mediastinal Gray Zone Lymphoma

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Biological processes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of activated T cell proliferationGO:004600710.3CD274, PDCD1LG2
2negative regulation of interferon-gamma productionGO:003268910.3CD274, PDCD1LG2
3negative regulation of interleukin-10 productionGO:003269310.3CD274, PDCD1LG2
4negative regulation of T cell proliferationGO:004213010.3CD274, PDCD1LG2
5negative regulation of transcription from RNA polymerase II promoterGO:00001229.3BCL11A, BCL6, PAX5, REL, XPO1
6positive regulation of apoptotic processGO:00430658.5BCL6, EPHA7, HOXA5, JAK2, TNFRSF8

Sources for Mediastinal Gray Zone Lymphoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet