MCID: MDS006
MIFTS: 29

Mediastinal Gray Zone Lymphoma malady

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Mediastinal Gray Zone Lymphoma

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Aliases & Descriptions for Mediastinal Gray Zone Lymphoma:

Name: Mediastinal Gray Zone Lymphoma 11 13
 
Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma 66

Classifications:



External Ids:

Disease Ontology11 DOID:6867
NCIt43 C37870

Summaries for Mediastinal Gray Zone Lymphoma

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MalaCards based summary: Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to gray zone lymphoma and hodgkin lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is PAX5 (Paired Box 5), and among its related pathways are Cytokine production by Th17 cells in CF and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Affiliated tissues include b cells, and related mouse phenotypes are cellular and immune system.

Related Diseases for Mediastinal Gray Zone Lymphoma

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Diseases related to Mediastinal Gray Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
idRelated DiseaseScoreTop Affiliating Genes
1gray zone lymphoma31.5BCL11A, PAX5
2hodgkin lymphoma28.6BCL6, CSF3, PAX5, REL, TNFRSF8
3lymphoma10.5
4mediastinitis10.5
5b-cell lymphomas10.4
6chromosome 2p16.1-p15 deletion syndrome10.3BCL11A, REL, XPO1
7malignant sertoli-leydig cell tumor10.3PAX5, TNFRSF8
8primary mediastinal large b-cell lymphoma10.3
9auricular cancer10.2FUT4, TNFRSF8
10adult lymphoma10.2BCL11A, CD274, PAX5, SLC22A2
11upper lip cancer10.1FUT4, PAX5, TNFRSF8
12nutritional deficiency disease10.0FUT4, TNFRSF8
13acute lymphoblastic leukemia, childhood9.9CSF3, JAK2, PAX5
14critical congenital heart disease9.9CSF3, JAK2
15idiopathic neutropenia9.8BCL6, PAX5
16pustulosis of palm and sole9.7FUT4, TNFRSF8
17teebi kaurah syndrome9.7BCL6, SLC22A2, TNFRSF8
18polyembryoma of the ovary9.6BCL6, PAX5, TNFRSF8
19chronic inflammatory demyelinating polyneuritis9.6BCL6, TNFRSF8
20drug-induced hepatitis9.5BCL6, REL, TNFRSF8
21congenital myasthenic syndrome9.5BCL6, FUT4, TNFRSF8
22minimally differentiated acute myeloblastic leukemia9.4BCL6, CD274, JAK2, REL
23bipolar disorder9.3BCL6, PAX5, REL, TNFRSF8
24smoking as a quantitative trait locus 19.1BCL6, CSF3, PAX5, TNFRSF8
25brachyolmia9.0BCL6, CSF3, JAK2, TNFRSF8
26hemolytic anemia8.4BCL6, CSF3, FUT4, JAK2, PAX5, TNFRSF8
27organ system benign neoplasm8.4BCL6, CSF3, FUT4, JAK2, PAX5, TNFRSF8
28hepatoblastoma5.4BCL11A, BCL6, CD274, CSF3, DAPK1, EPHA7
29parasagittal meningioma5.2BCL11A, BCL6, CD274, CSF3, DAPK1, EPHA7

Graphical network of the top 20 diseases related to Mediastinal Gray Zone Lymphoma:



Diseases related to mediastinal gray zone lymphoma

Symptoms for Mediastinal Gray Zone Lymphoma

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Drugs & Therapeutics for Mediastinal Gray Zone Lymphoma

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Drugs for Mediastinal Gray Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabPhase 21611174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2Alkylating AgentsPhase 24573

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Phase I/II Study Of Brentuximab Vedotin In Combination With Multi-Agent Chemotherapy As Front-Line Treatment In Patients With CD30 Positive Primary Mediastinal Large B-Cell, Diffuse Large B-Cell, And Grey Zone LymphomasRecruitingNCT01994850Phase 1, Phase 2
2Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin LymphomaRecruitingNCT02623920Phase 2
3Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's LymphomaRecruitingNCT00001337Phase 2

Search NIH Clinical Center for Mediastinal Gray Zone Lymphoma

Genetic Tests for Mediastinal Gray Zone Lymphoma

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Anatomical Context for Mediastinal Gray Zone Lymphoma

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MalaCards organs/tissues related to Mediastinal Gray Zone Lymphoma:

34
B cells

Animal Models for Mediastinal Gray Zone Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Mediastinal Gray Zone Lymphoma:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.2BCL11A, BCL6, CD274, DAPK1, FUT4, HOXA5
2MP:00053875.5BCL11A, BCL6, CD274, CSF3, FUT4, GPR15
3MP:00053975.3BCL11A, BCL6, CD274, CSF3, FUT4, GPR15

Publications for Mediastinal Gray Zone Lymphoma

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Articles related to Mediastinal Gray Zone Lymphoma:

(show all 13)
idTitleAuthorsYear
1
Mediastinal Gray Zone Lymphoma with Features Intermediate between Classical Hodgkin Lymphoma and Primary Mediastinal B-Cell Lymphoma. (27623181)
2016
2
Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? (26957476)
2016
3
Mediastinal Gray Zone Lymphoma. (27164737)
2015
4
Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? (25499450)
2015
5
A prospective study of mediastinal gray-zone lymphoma. (25024303)
2014
6
Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do? (21590365)
2011
7
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. (21454882)
2011
8
Primary mediastinal (thymic) large B-cell lymphoma: a short review with brief discussion of mediastinal gray zone lymphoma. (21366467)
2011
9
Mediastinal gray zone lymphoma. (21454881)
2011
10
Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children. (20971819)
2011
11
Two cases of mediastinal gray zone lymphoma. (21123972)
2010
12
Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. (16224207)
2005
13
Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. (15322489)
2004

Variations for Mediastinal Gray Zone Lymphoma

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Expression for genes affiliated with Mediastinal Gray Zone Lymphoma

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Search GEO for disease gene expression data for Mediastinal Gray Zone Lymphoma.

Pathways for genes affiliated with Mediastinal Gray Zone Lymphoma

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GO Terms for genes affiliated with Mediastinal Gray Zone Lymphoma

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Biological processes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of activated T cell proliferationGO:004600710.2CD274, PDCD1LG2
2negative regulation of interferon-gamma productionGO:003268910.2CD274, PDCD1LG2
3positive regulation of myeloid cell differentiationGO:004563910.1CSF3, HOXA5
4negative regulation of interleukin-10 productionGO:003269310.0CD274, PDCD1LG2
5immune responseGO:00069558.6CD274, CSF3, PDCD1LG2, TNFRSF8
6negative regulation of transcription from RNA polymerase II promoterGO:00001228.5BCL11A, BCL6, PAX5, REL, XPO1
7positive regulation of apoptotic processGO:00430658.5BCL6, EPHA7, HOXA5, JAK2, TNFRSF8

Sources for Mediastinal Gray Zone Lymphoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet