MCID: MDS006
MIFTS: 32

Mediastinal Gray Zone Lymphoma

Categories: Immune diseases, Cancer diseases

Aliases & Classifications for Mediastinal Gray Zone Lymphoma

MalaCards integrated aliases for Mediastinal Gray Zone Lymphoma:

Name: Mediastinal Gray Zone Lymphoma 12 14
Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:6867
NCIt 46 C37870
UMLS 69 C1334657

Summaries for Mediastinal Gray Zone Lymphoma

MalaCards based summary : Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to gray zone lymphoma and primary mediastinal large b-cell lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is PAX5 (Paired Box 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and NF-kappaB Signaling. The drugs nivolumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include b cells, and related phenotypes are cellular and hematopoietic system

Related Diseases for Mediastinal Gray Zone Lymphoma

Diseases related to Mediastinal Gray Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 gray zone lymphoma 30.9 BCL11A CD274 EPHA7 PAX5 SLC22A2
2 primary mediastinal large b-cell lymphoma 30.6 BCL6 CD274 JAK2
3 b-cell lymphomas 30.5 BCL6 PAX5 REL TNFRSF8
4 lymphoma 30.5 BCL11A BCL6 PAX5 REL TNFRSF8
5 lymphoma, hodgkin, classic 29.3 BCL6 FSCN1 PAX5 REL TNFRSF8
6 mediastinitis 10.5
7 nodular lymphocyte predominant hodgkin lymphoma 10.4 BCL6 PAX5
8 chromosome 2p16.1-p15 deletion syndrome 10.3 BCL11A REL XPO1
9 composite lymphoma 10.3 BCL6 PAX5
10 intraocular lymphoma 10.3 BCL6 PAX5
11 malignant leydig cell tumor 10.3 PAX5 TNFRSF8
12 t-cell/histiocyte rich large b cell lymphoma 10.2 BCL6 SLC22A2 TNFRSF8
13 sternum cancer 10.2 FUT4 TNFRSF8
14 lung lymphoma 10.1 BCL6 PAX5 TNFRSF8
15 reticulosarcoma 10.1 BCL6 PAX5 TNFRSF8
16 colon lymphoma 10.1 BCL6 TNFRSF8
17 myasthenic syndrome, congenital, 14 10.0 CD274 JAK2 PDCD1LG2
18 epidural neoplasm 10.0 BCL6 FUT4 TNFRSF8
19 primary central nervous system lymphoma 10.0 BCL6 PAX5
20 epstein-barr virus-associated gastric carcinoma 10.0 CD274 JAK2 PDCD1LG2
21 diffuse large b-cell lymphoma 10.0 BCL6 PAX5 REL TNFRSF8
22 testicular infarct 9.9 FUT4 TNFRSF8
23 reticulohistiocytic granuloma 9.6 FSCN1 FUT4 TNFRSF8
24 hematologic cancer 9.6 IL3RA JAK2 PAX5 TNFRSF8
25 hodgkin's lymphoma, lymphocytic depletion 9.2 FSCN1 FSCN3 FUT4 PAX5 TNFRSF8
26 mediastinal malignant lymphoma 5.8 BCL11A BCL6 CD274 DAPK1 EPHA7 FSCN1

Graphical network of the top 20 diseases related to Mediastinal Gray Zone Lymphoma:



Diseases related to Mediastinal Gray Zone Lymphoma

Symptoms & Phenotypes for Mediastinal Gray Zone Lymphoma

MGI Mouse Phenotypes related to Mediastinal Gray Zone Lymphoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.9 BCL11A BCL6 CD274 DAPK1 FSCN1 FUT4
2 hematopoietic system MP:0005397 9.77 TNFRSF8 BCL11A BCL6 CD274 FUT4 GPR15
3 immune system MP:0005387 9.47 BCL11A BCL6 CD274 FSCN1 FUT4 GPR15

Drugs & Therapeutics for Mediastinal Gray Zone Lymphoma

Drugs for Mediastinal Gray Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 1, Phase 2 946414-94-4
2 Antibodies Phase 1, Phase 2
3 Antibodies, Monoclonal Phase 1, Phase 2
4 Immunoglobulins Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Investigational Immuno-therapy Safety and Effectiveness Study of Nivolumab in Combination With Brentuximab Vedotin to Treat Non-Hodgkin Lymphomas Recruiting NCT02581631 Phase 1, Phase 2 Brentuximab Vedotin
2 Mediastinal Grey Zone Lymphoma From the LYSA Completed NCT03037177

Search NIH Clinical Center for Mediastinal Gray Zone Lymphoma

Genetic Tests for Mediastinal Gray Zone Lymphoma

Anatomical Context for Mediastinal Gray Zone Lymphoma

MalaCards organs/tissues related to Mediastinal Gray Zone Lymphoma:

38
B Cells

Publications for Mediastinal Gray Zone Lymphoma

Articles related to Mediastinal Gray Zone Lymphoma:

(show all 16)
# Title Authors Year
1
Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association. ( 27758822 )
2017
2
Dendritic Cell Markers and PD-L1 are Expressed in Mediastinal Gray Zone Lymphoma. ( 29189264 )
2017
3
PD-1 Blockade in Mediastinal Gray-Zone Lymphoma. ( 28679093 )
2017
4
Mediastinal Gray Zone Lymphoma with Features Intermediate between Classical Hodgkin Lymphoma and Primary Mediastinal B-Cell Lymphoma. ( 27623181 )
2016
5
Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? ( 26957476 )
2016
6
Mediastinal Gray Zone Lymphoma. ( 27164737 )
2015
7
Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? ( 25499450 )
2015
8
A prospective study of mediastinal gray-zone lymphoma. ( 25024303 )
2014
9
Mediastinal gray zone lymphoma. ( 21454881 )
2011
10
Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children. ( 20971819 )
2011
11
Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do? ( 21590365 )
2011
12
Primary mediastinal (thymic) large B-cell lymphoma: a short review with brief discussion of mediastinal gray zone lymphoma. ( 21366467 )
2011
13
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. ( 21454882 )
2011
14
Two cases of mediastinal gray zone lymphoma. ( 21123972 )
2010
15
Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. ( 16224207 )
2005
16
Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. ( 15322489 )
2004

Variations for Mediastinal Gray Zone Lymphoma

Expression for Mediastinal Gray Zone Lymphoma

Search GEO for disease gene expression data for Mediastinal Gray Zone Lymphoma.

Pathways for Mediastinal Gray Zone Lymphoma

GO Terms for Mediastinal Gray Zone Lymphoma

Cellular components related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection membrane GO:0031253 8.62 FSCN1 FSCN3

Biological processes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell migration GO:0016477 9.46 FSCN1 FSCN3 HOXA5 JAK2
2 negative regulation of interleukin-10 production GO:0032693 9.32 CD274 PDCD1LG2
3 negative regulation of activated T cell proliferation GO:0046007 9.26 CD274 PDCD1LG2
4 positive regulation of apoptotic process GO:0043065 9.1 BCL6 EPHA7 HMOX1 HOXA5 JAK2 TNFRSF8
5 negative regulation of mast cell cytokine production GO:0032764 8.96 BCL6 HMOX1

Sources for Mediastinal Gray Zone Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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