MCID: MDS022
MIFTS: 56

Mediastinitis malady

Summaries for Mediastinitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

MalaCards: Mediastinitis is related to seminoma and sarcoma. An important gene associated with Mediastinitis is TNFAIP2 (tumor necrosis factor, alpha-induced protein 2), and among its related pathways are Rho Family GTPases and Development PDGF signaling via STATs and NF-kB. The compounds retinoic acid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include b cells, lymph node and lung, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Mediastinitis

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 27ICD9CM, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

mediastinitis 8 10 60


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Disease Ontology8 DOID:819
NCIt39 C26827
SNOMED-CT56 47597000
ICD9CM27 519.2
MeSH34 D008480

Related Diseases for Mediastinitis

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17GeneCards, 18GeneDecks
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Diseases related to Mediastinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 489)
idRelated DiseaseScoreTop Affiliating Genes
1seminoma30.7ALPPL2, AFP
2sarcoma30.7TP53, JAK2
3esophagitis30.7IL13
4leukemia30.5CSF3, JAK2, MLLT10, NFKB1, MYC, REL
5lung cancer30.5CSF3, MYC, TP53
6hodgkin's lymphoma30.4CSF3, JAK2, STAT6, REL, IL13, PAX5
7diffuse large b-cell lymphoma30.4MUM1
8acute leukemia30.3CSF3, JAK2, MLLT10, PAX5
9pancreatitis30.3ALPPL2
10graves' disease30.2IL13, STAT6
11myeloid leukemia30.2MYC, MLLT10, JAK2, CSF3
12lung small cell carcinoma30.2CSF3, MYC, PAX5, TP53
13plasmacytoma30.2MYC, PAX5, BCL6
14endodermal sinus tumor30.2AFP, ALPPL2
15hyperparathyroidism30.2ALPPL2
16choriocarcinoma30.1ALPPL2, AFP, JAK2
17adenocarcinoma30.1JAK2, AFP, MYC, TP53
18neuroblastoma30.1TP53, MYC
19hypercalcemia30.1ALPPL2
20burkitt's lymphoma29.9CSF3, JAK2, STAT6, MYC, REL, PAX5
21hepatitis29.9AFP
22anaplastic large cell lymphoma29.8BCL6, PAX5
23arthritis29.8STAT6, IL13, ALPPL2
24down syndrome29.8JAK2, AFP
25bronchiolitis29.8IL13
26myeloma29.6CSF3, JAK2, MYC, PAX5, BCL6, ALPPL2
27breast cancer29.6CSF3, JAK2, STAT6, NFKB1, MYC, REL
28rheumatoid arthritis29.6JAK2, STAT6, CD274, IL13
29multiple myeloma29.6TP53, CSF3
30non-hodgkin lymphoma29.6CSF3, JAK2, MYC, PAX5, BCL6
31colon cancer29.6JAK2, STAT6, MYC, ALPPL2, TP53
32central nervous system lymphoma29.6BCL6
33glioblastoma multiforme29.6JAK2, STAT6, MYC, IL13, TP53
34atherosclerosis29.6STAT6
35astrocytoma29.6TP53, PAX5, IL13
36dilated cardiomyopathy29.6STAT6
37hyperthyroidism29.6ALPPL2
38malt lymphoma29.6BCL6
39esophageal cancer29.6TP53
40adenoma10.6
41parathyroid adenoma10.6
42mediastinal cancer10.5
43mediastinal lipomatosis10.5
44lipomatosis10.5
45cervicitis10.4
46goiter10.4
47lymphangioma10.4
48lymphadenitis10.4
49mature teratoma10.4
50liposarcoma10.4

Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to mediastinitis

Clinical Features for Mediastinitis

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Drugs & Therapeutics for Mediastinitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mediastinitis

Drug clinical trials:

Search ClinicalTrials for Mediastinitis

Search NIH Clinical Center for Mediastinitis

Search CenterWatch for Mediastinitis

Genetic Tests for Mediastinitis

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Anatomical Context for Mediastinitis

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32MalaCards
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MalaCards organs/tissues related to Mediastinitis:

32
B cells, Lymph node, Lung, Heart, Thyroid, Myeloid, T cells, Bone, Liver, Skin, Breast, Colon, Tonsil, Trachea, Bone marrow, Thymus, Spinal cord, Prostate, Testes, Kidney, Ovary, Monocytes, Brain, Pancreas, Spleen, Pituitary

Animal Models for Mediastinitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mediastinitis:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.8TP53, CSF3, FOXN1, JAK2, STAT6, NFKB1
2MP:000538710.8CSF3, FOXN1, JAK2, STAT6, NFKB1, MYC
3MP:000538410.8FOXN1, JAK2, STAT6, NFKB1, MYC, CD274
4MP:001077110.8FOXN1, STAT6, MYC, REL, IL13, TP53
5MP:001076810.8NFKB1, AFP, STAT6, JAK2, FOXN1, MYC
6MP:000537610.7FOXN1, JAK2, STAT6, AFP, NFKB1, MYC
7MP:000539010.7FOXN1, JAK2, MYC, PAX5
8MP:000537010.7FOXN1, STAT6, NFKB1, MYC, REL, BCL6
9MP:000538910.6FOXN1, STAT6, AFP, MYC, IL13, TP53
10MP:000537810.6FOXN1, JAK2, STAT6, NFKB1, MYC, REL
11MP:000537710.5IL13, FOXN1
12MP:000200610.4FOXN1, STAT6, AFP
13MP:000537910.2TP53, MYC, AFP, JAK2, FOXN1

Publications for Mediastinitis

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50PubMed
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Articles related to Mediastinitis:

(show top 50)    (show all 1742)
idTitleAuthorsYear
1
Dysphagia due to a cystic mediastinal mass. (23274693)
2013
2
Performance of integrated positron emission tomography/computed tomography for mediastinal nodal staging in non-small cell lung carcinoma. (23566971)
2013
3
Bilateral mediastinal neurofibroma of the vagus nerves in a patient with neurofibromatosis type 1. (23232267)
2013
4
Mediastinal mature teratoma with complex rupture into the lung, bronchus and skin: a case report. (23725382)
2013
5
Descending Necrotizing Mediastinitis: A Modified Algorithmic Approach To Define a New Standard of Care. (24351133)
2013
6
Salvage therapy with high-dose chemotherapy and peripheral blood stem cell transplant in patients with primary mediastinal nonseminomatous germ cell tumors. (22892555)
2013
7
Non-Hodgkin's lymphoma presenting as a mediastinal mass in a 38-year-old patient with superior vena cava syndrome and extreme fatigue owing to left atrium and right ventricle outflow tract compression: the applicability of strain imaging. (22669866)
2012
8
Unusual presentation of sarcoid-like reaction on bone marrow level associated with mediastinal lymphadenopathy on (18)F-FDG-PET/CT resembling an early recurrence of Hodgkin's Lymphoma. (22980128)
2012
9
Preoperative risk factors for mediastinitis after cardiac surgery: analysis of 2768 patients. (22996970)
2012
10
Pericardial cyst or teratoma? Change of strategy during mediastinal tumor surgery. (21766280)
2012
11
Does method of sternal repair influence long-term outcome of postoperative mediastinitis? (21924401)
2011
12
A case of Candida mediastinitis after dental extraction. (21330746)
2011
13
Primary mediastinal large B-cell lymphoma: optimal therapy and prognostic factors in 41 consecutive Asian patients. (21261504)
2011
14
Skeletonized internal thoracic artery is associated with lower rates of mediastinitis in elderly undergoing coronary artery bypass grafting surgery. (22358278)
2011
15
Mediastinal extragonadal seminoma presenting as severe back pain in a young male. (22073516)
2011
16
Chest wall reconstruction of severe mediastinitis with intercostal artery-based pedicled vertical rectus abdominis muscle flap with oblique-designed skin pedicle. (21587058)
2011
17
Radiotherapy of unicentric mediastinal Castleman's disease. (21527068)
2011
18
Rosai-Dorfman disease manifesting as a mediastinal mass with calcifications. (20351578)
2010
19
Mediastinal solitary fibrous tumor with right diaphragm invasion: report of a case. (19319642)
2009
20
No evidence for the JAK2 (V617F) or JAK2 exon 12 mutations in primary mediastinal large B-cell lymphoma. (19704259)
2009
21
Fibrosing mediastinitis as an untypical complication of tuberculosis: case report. (19920801)
2009
22
Mediastinal spread of metastatic lymph nodes in bronchogenic carcinoma. Mediastinal nodal metastases in lung cancer. 1990. (20162824)
2009
23
An unusual case of Aspergillus fibrosing mediastinitis. (19766844)
2009
24
Pharmacokinetics and tolerance of linezolid for meticillin-resistant Staphylococcus aureus mediastinitis in paediatric patients. (19097868)
2009
25
Radio-guided surgical excision of an ectopic mediastinal parathyroid adenoma demonstrated on Tc-99m sestamibi hybrid imaging. (19220551)
2009
26
Successful treatment of a patient with Klinefelter's syndrome complicated by mediastinal germ cell tumor and AML(M7). (18223696)
2008
27
Adenocarcinoma arising in anterior mediastinal mature cystic teratoma: report of a case. (18368326)
2008
28
Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver. (17955548)
2008
29
One-and-a-half ventricular repair through the right lateral thoracotomy: an alternative to midline approach in a patient with previous mediastinitis. (19131927)
2008
30
Clinical utility of 99mTc-labeled ubiquicidin 29-41 antimicrobial peptide for the scintigraphic detection of mediastinitis after cardiac surgery. (18996290)
2008
31
Testicular seminoma presenting with mediastinal lymphadenopathy and gynecomastia. (17634885)
2007
32
Expression of TRAF1 and nuclear c-Rel distinguishes primary mediastinal large cell lymphoma from other types of diffuse large B-cell lymphoma. (17197926)
2007
33
Incidental discovery of an anterior mediastinal angiomyolipoma. (17527125)
2007
34
Successful treatment of descending necrotizing mediastinitis. (17937050)
2007
35
Aspiration cytology of mediastinal seminoma: report of a case with emphasis on the diagnostic role of aspiration cytology, cell block and immunocytochemistry. (16450911)
2005
36
Life-threatening airway obstruction caused by mediastinal germinoma in a 9-year-old girl. (15793744)
2005
37
Cure of a patient with profoundly chemotherapy-refractory primary mediastinal large B-cell lymphoma: role of rituximab, high-dose therapy, and allogeneic stem cell transplantation. (16019561)
2005
38
Descending necrotizing mediastinitis following lingual tonsillectomy and elective tracheotomy. (16213954)
2005
39
Outcome of patients with residual germ cell or non-germ cell malignancy after resection of primary mediastinal nonseminomatous germ cell cancer. (15051766)
2004
40
Burkitt's lymphoma with bilateral cavernous sinus and mediastinal involvement in a child. (12879319)
2003
41
Expression of hMLH1 and hMSH2 and assessment of microsatellite instability in testicular and mediastinal germ cell tumours. (11719586)
2001
42
Mediastinal neurilemmoma complicated with spinal subarachnoid hemorrhage. (11481844)
2001
43
Childhood T-cell lymphoblastic lymphoma--does early resolution of mediastinal mass predict for final outcome? The United Kingdom Children's Cancer Study Group (UKCCSG). (7669589)
1995
44
Case report: the computed tomographic features of mediastinal bronchogenic cyst rupture into the bronchial tree. (8032814)
1994
45
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 7-1989. Unilateral exophthalmos three years after treatment of cervical and mediastinal Hodgkin's disease. (2913509)
1989
46
Mediastinal zygomycosis. (4041039)
1985
47
Echocardiographic findings in a case of acquired pulmonic stenosis from extrinsic compression by a mediastinal cyst. (7273901)
1981
48
Mediastinal extramedullary plasmacytoma. (7375991)
1980
49
Computed tomography in the evaluation of mediastinal lipomatosis. (701514)
1978
50
A case report of mediastinal neurogenic neoplasm containing arteriovenous fistulas. (6021416)
1967

Genetic Variations for Mediastinitis

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Expression for genes affiliated with Mediastinitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Pathways for genes affiliated with Mediastinitis

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Sources:
51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 53Reactome
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Pathways related to Mediastinitis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CSF3, JAK2, STAT6, NFKB1, MYC, IL13
2
Development PDGF signaling via STATs and NF-kB
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10.5REL, MYC, NFKB1, STAT6, JAK2
310.5TP53, BCL6, PAX5, REL, MYC, NFKB1
4
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10.5CSF3, JAK2, STAT6, NFKB1, IL13, TP53
5
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10.5STAT6, NFKB1, REL, IL13, BCL6
6
Hide members
10.5CSF3, JAK2, NFKB1, MYC, IL13, TP53
710.5IL13, MYC, STAT6, JAK2, CSF3
8
Hide members
10.5JAK2, STAT6, NFKB1, REL
9
Hide members
10.5JAK2, STAT6, NFKB1, IL13
10
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10.5MYC, NFKB1, STAT6, JAK2
1110.5JAK2, STAT6, NFKB1, MYC
12
Hide members
10.5JAK2, STAT6, NFKB1, MYC
13
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10.5REL, MYC, NFKB1, JAK2
14
Development Prolactin receptor signaling
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10.5JAK2, NFKB1, MYC, REL
15
Immune response IL-2 activation and signaling pathway
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10.5JAK2, NFKB1, MYC, REL
1610.5TP53, IL13, NFKB1, AFP
17
Hide members
10.5TP53, MYC, NFKB1, STAT6
1810.5NFKB1, MYC, REL, TP53
19
Hide members
10.5TP53, REL, MYC, NFKB1
2010.5CSF3, JAK2, NFKB1, MYC, TP53
21
Cytokine production by Th17 cells in CF (Mouse model)
10.5CSF3, JAK2, NFKB1, REL
2210.5NFKB1, STAT6, JAK2
23
Hide members
10.5JAK2, STAT6, NFKB1
2410.5JAK2, STAT6, NFKB1
25
Mucin expression in CF via IL-6, IL-17 signaling pathways
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10.5REL, NFKB1, JAK2
26
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10.5REL, NFKB1, JAK2
27
Immune response Bacterial infections in normal airways
10.5JAK2, NFKB1, REL
2810.5REL, MYC, NFKB1
29
Development A3 receptor signaling
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10.5NFKB1, MYC, REL
30
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10.5NFKB1, MYC, BCL6, TP53
31
Transcription P53 signaling pathway
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10.5TP53, REL, NFKB1
32
Hide members
10.5TP53, REL, NFKB1
33
Development EPO-induced Jak-STAT pathway
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10.5JAK2, NFKB1, MYC
34
Hide members
10.5TP53, NFKB1, JAK2
35
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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10.5TP53, NFKB1, JAK2
36
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10.5IL13, STAT6
37
Hide members
10.5NFKB1, MYC, TP53
3810.5TP53, MYC, NFKB1
39
Hide members
10.5TP53, MYC, NFKB1
4010.5NFKB1, MYC, BCL6
4110.5NFKB1, REL

Compounds for genes affiliated with Mediastinitis

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 2BitterDB
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Compounds related to Mediastinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.0TP53, CSF3, TNFAIP2, JAK2, STAT6, AFP
2tyrosine4411.0REL, MYC, AFP, STAT6, JAK2, CSF3
3dexamethasone44 49 28 1114.0STAT6, AFP, MYC, REL, IL13
4serine4411.0IL4I1, STAT6, AFP, IL13, JAK2
5actinomycin d4411.0TP53, AFP, STAT6, JAK2, MYC, IL13
6hydroxyurea44 49 1113.0MYC, CSF3, JAK2, TP53, IL13
7oligonucleotide4411.0REL, PAX5, JAK2, STAT6, AFP, MYC
8vincristine44 49 1113.0CSF3, AFP, MYC, BCL6, TP53
9cyclophosphamide44 49 1113.0AFP, TP53, IL13, BCL6, CSF3
10doxorubicin44 49 1113.0TP53, BCL6, MYC, CSF3, AFP, IL13
11cytidine44 11 2412.9MYC, PAX5, BCL6, STAT6
1210-hydroxycamptothecin4410.9MYC, TP53, AFP
13paraffin4410.9PAX5, AFP, BCL6, ALPPL2, MYC, TP53
14thymidine44 2411.9TP53, MYC, CSF3, IL13, AFP, JAK2
15melphalan44 1111.9IL4I1, TP53, CSF3, MYC
16rituximab44 49 1112.9IL13, PAX5, CSF3, BCL6
17bleomycin44 1111.9IL13, AFP, TP53, CSF3
18etoposide44 49 59 1113.9AFP, TP53, MYC, CSF3, NFKB1
19amifostine44 1111.9ALPPL2, CSF3, TP53
20mg 13244 5911.9MYC, JAK2, TP53, STAT6
21adriamycin4410.9AFP, MYC, TP53, CSF3
225-aza-2deoxycytidine4410.9MYC, TP53, JAK2, MAL
23cyclosporin a44 28 5912.9CSF3, MYC, JAK2, REL, IL13
24threonine4410.9STAT6, REL, AFP, MYC, IL13, JAK2
25butyrate4410.9ALPPL2, JAK2
26imatinib44 49 1112.9MYC, BCL6, CSF3, JAK2
27vegf4410.9AFP, MYC, IL13, TP53, CSF3, JAK2
28tachyplesin i4410.9MYC, AFP
29estrogen4410.9BCL6
30tanshinone iia4410.8MYC, TP53
31anti-fungal4410.8CSF3, AFP, REL
32cisplatin44 49 59 1113.8JAK2, TP53, AFP, CSF3, MYC
33chloramphenicol44 2 1112.8AFP, MYC, IL13, REL
34leucine4410.8MYC, MLLT10, JAK2, IL4I1, ALPPL2
35vinblastine44 49 1112.8TP53, AFP
36acnu4410.8TP53, CSF3
37irinotecan44 49 1112.8TP53, AFP, CSF3
38acetaminophen44 2 49 11 2414.8IL13, MYC, AFP
39n acetylcysteine4410.8STAT6, MYC, JAK2, TP53
40carboplatin44 49 1112.7TP53, CSF3, AFP
414-hydroperoxycyclophosphamide4410.7CSF3, MYC
42sb 20358044 5911.7JAK2, TP53, IL13, STAT6
43aclarubicin4410.7CSF3, MYC
44thalidomide44 49 59 1113.7AFP, NFKB1, IL13
45h2o24410.6IL4I1, JAK2, AFP, IL13, TP53
46vesnarinone4410.6MYC, CSF3
47paclitaxel44 49 1112.5CSF3, AFP, TP53, MYC
48mitomycin c4410.5CSF3, AFP, TP53
49gemcitabine44 49 1112.4CSF3, TP53, MYC
50gp 1304410.2JAK2, IL13, CSF3

GO Terms for genes affiliated with Mediastinitis

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Sources:
16Gene Ontology
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Cellular components related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.5TP53, BCL6

Biological processes related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:00012210.5TP53, FOXN1, STAT6, NFKB1, MYC, PAX5
2positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5TP53, JAK2, CSF3
3positive regulation of transcription from RNA polymerase II promoterGO:04594410.4CSF3, STAT6, MLLT10, NFKB1, MYC, PAX5
4negative regulation of type 2 immune responseGO:00282910.2BCL6, STAT6

Molecular functions related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:00813410.5TP53, MYC, NFKB1, FOXN1
2sequence-specific DNA binding transcription factor activityGO:00370010.2TP53, STAT6, MLLT10, NFKB1, MYC, REL

Products for genes affiliated with Mediastinitis

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  • Antibodies
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Sources for Mediastinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet