MCID: MDS022
MIFTS: 46

Mediastinitis malady

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Summaries for Mediastinitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

MalaCards: Mediastinitis is related to tuberculosis and pancreatitis. An important gene associated with Mediastinitis is MPO (myeloperoxidase), and among its related pathways is Selenium Pathway. The compounds cefdinir and cefaclor have been mentioned in the context of this disorder. Affiliated tissues include b cells, lymph node and lung.

Aliases & Classifications for Mediastinitis

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8Disease Ontology, 10DISEASES, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM, 40NCIt
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Aliases & Descriptions:

mediastinitis 8 10 62


External Ids:

Disease Ontology8 DOID:819
MeSH35 D008480
SNOMED-CT58 47597000
ICD9CM27 519.2
NCIt40 C26827

Related Diseases for Mediastinitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to mediastinitis

Symptoms for Mediastinitis

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Drugs & Therapeutics for Mediastinitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Mediastinitis

Search NIH Clinical Center for Mediastinitis

Genetic Tests for Mediastinitis

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Anatomical Context for Mediastinitis

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33MalaCards
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MalaCards organs/tissues related to Mediastinitis:

33
B cells, Lymph node, Lung, Heart, Thyroid, Myeloid, Bone, T cells, Liver, Breast, Skin, Tonsil, Colon, Bone marrow, Thymus, Trachea, Spinal cord, Prostate, Pancreas, Brain, Monocytes, Ovary, Spleen, Kidney, Testes, Pituitary

Animal Models for Mediastinitis or affiliated genes

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Publications for Mediastinitis

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52PubMed
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Articles related to Mediastinitis:

(show top 50)    (show all 1724)
idTitleAuthorsYear
1
Clinical utility and economic impact of conventional transbronchial needle aspiration of mediastinal lymphadenopathies in bronchogenic carcinoma. (23083635)
2013
2
Mediastinal goiter presenting with ventricular tachycardia. (22302698)
2013
3
Mediastinal hemangioma: Masquerading as pleural effusion. (24347874)
2013
4
Zygomycotic Mediastinal Lymphadenitis in Beef Cattle with Ruminal Tympany. (24018826)
2013
5
Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene. (23457195)
2013
6
Embryonal rhabdomyosarcoma arising from a mediastinal teratoma: an unusual case report. (23487585)
2013
7
Probable initial pulmonary lymphangioleiomyomatosis and mediastinal lymphangioleiomyoma. (24268918)
2013
8
Isolated mediastinal amyloidosis mimicking a neoplastic lesion. (23585190)
2013
9
Mediastinitis: mortality rate comparing single-stage surgical approach and preconditioning of wound. (23939316)
2013
10
Mediastinal lymphangioma treated using endobronchial ultrasound-guided transbronchial needle aspiration. (23018866)
2012
11
Fibrosing mediastinitis as a cause of right claudication. (21562863)
2012
12
Combined spontaneous contralateral pneumothorax and post-pneumonectomy mediastinal shift-associated dextrocardia. (21243579)
2011
13
Mediastinal epithelioid hemangioendothelioma mimicking a teratoma. (21492982)
2011
14
Isolated mediastinal myeloid sarcoma successfully treated with chemoradiotherapy followed by unrelated allogeneic stem cell transplantation. (22185993)
2011
15
A case of an elderly patient treated for descending necrotizing mediastinitis. (22231792)
2011
16
An aortic root pseudoaneurysm that developed after implantation of a rectus abdominis muscle flap to treat an MRSA mediastinitis: a case report. (20190716)
2010
17
Two cases of mediastinal gray zone lymphoma. (21123972)
2010
18
Images for surgeons. A case of matured mediastinal teratoma complicated by cardiac tamponade: an unusual aetiology. (21061752)
2010
19
Iniencephaly with mediastinal bronchogenic cyst: A case report. (22439066)
2010
20
Mediastinal mature cystic teratoma perforating into the lung. (20876619)
2010
21
Influence of suboptimal treatment in patients with mediastinal primary nonseminomatous germ cell tumors. (20185939)
2010
22
Severe deep neck space infections and mediastinitis of odontogenic origin: clinical relevance and implications for diagnosis and treatment. (18607917)
2009
23
Primary mediastinal large B-cell lymphoma in HIV: report of two cases. (19669223)
2009
24
The role of omental transposition for the management of postoperative mediastinitis: a case series. (19236690)
2009
25
Mediastinal solitary fibrous tumor with right diaphragm invasion: report of a case. (19319642)
2009
26
Multidrug-resistant Klebsiella pneumoniae mediastinitis safely and effectively treated with prolonged administration of tigecycline. (18540810)
2008
27
Unusual features of malignant pleural mesothelioma metastatic to the mediastinal lymph nodes. (18301236)
2008
28
Mediastinal lymphatic drainage from pulmonary lobe based on CT observations of histoplasmosis: implications for minimal N2 disease of non-small-cell lung cancer. (17952543)
2007
29
High expression of several tyrosine kinases and activation of the PI3K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma. (17375124)
2007
30
Sigmoid colon cancer with mediastinal lymph node metastases. (18050829)
2007
31
Cold agglutinin disease revealing mediastinal seminoma. (17449873)
2007
32
Acute suppurative thyroiditis extending to descending necrotizing mediastinitis and pericarditis. (17381365)
2007
33
Mediastinal Castleman disease mimicking mediastinal pulmonary sequestration. (16077341)
2005
34
Acute mediastinitis resulting from an unsuspected fish bone--case report. (15875620)
2005
35
Calcified metastatic mediastinal lymph nodes from mucinous breast adenocarcinoma. (14566424)
2004
36
Congenital diaphragmatic eventration as a cause of anterior mediastinal mass in the children: imaging modalities and literature review. (15186890)
2004
37
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. (15377470)
2004
38
Cushing's syndrome with mediastinal lipomatosis. (15322612)
2004
39
Usefulness of routine epicardial pacing wire culture for early prediction of poststernotomy mediastinitis. (15528721)
2004
40
Pathobiology of primary mediastinal B-cell lymphoma. (15202521)
2003
41
Critical care transesophageal endosonography and guided fine-needle aspiration for diagnosis and management of posterior mediastinitis. (12545005)
2003
42
Role of radiation therapy in the management of primary mediastinal large B-cell lymphoma (PMLBL). (12553345)
2002
43
Expression of hMLH1 and hMSH2 and assessment of microsatellite instability in testicular and mediastinal germ cell tumours. (11719586)
2001
44
Preoperative embolization in surgical treatment of mediastinal hemangiopericytoma. (10750792)
2000
45
Posterior mediastinal capillary hemangioma with extradural extension resembling neuroblastoma. (10398787)
1999
46
Transcription of the nude gene (WHN) in human normal organs and mediastinal and pulmonary tumors. (10483588)
1999
47
Mediastinal bronchogenic cyst manifesting as a catastrophic myocardial infarction. (10391298)
1999
48
A patient with a relapse of myasthenia gravis after a 13-year remission following successful treatment by mediastinal irradiation and corticosteroid therapy]. (7605688)
1995
49
Mediastinal mass with acute leukemia. Myeloblastoma masquerading as lymphoblastic lymphoma. (6937159)
1981
50
Mediastinal extramedullary plasmacytoma. (7375991)
1980

Variations for Mediastinitis

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Expression for genes affiliated with Mediastinitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mediastinitis

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Pathways for genes affiliated with Mediastinitis

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50PathCards, 38NCBI BioSystems Database
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Pathways related to Mediastinitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway38
9.1CRP, MPO

Compounds for genes affiliated with Mediastinitis

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Sources:
45Novoseek, 11DrugBank, 3BitterDB, 51PharmGKB, 29IUPHAR, 24HMDB, 61Tocris Bioscience
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Compounds related to Mediastinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1cefdinir45 1110.9MPO, LACTB
2cefaclor45 1110.9LACTB, MPO
3ampicillin45 1110.8LACTB, MPO
4linezolid45 1110.8F5, LACTB
5nafamostat mesilate459.8F5, MPO
6cefotaxime45 1110.8F5, LACTB
7vancomycin45 1110.8LACTB, F5
8bivalirudin45 1110.8MPO, F5
9taurine chloramine459.7MPO, F5
10erythromycin45 3 51 1112.7MPO, LACTB
11ofloxacin45 3 1111.7LACTB, F5
12penicillin459.7F5, LACTB
13ciprofloxacin45 51 1111.7LACTB, F5
14fluorescein45 1110.7F5, MPO
15dextran sulfate459.7F5, MPO
16kininogen459.6F5, MPO
17aopp459.6CRP, MPO
18azithromycin45 1110.5LACTB, CRP
19d penicillamine459.5CRP, MPO
20sulfasalazine29 45 51 1112.5CRP, MPO
218-isoprostane459.5MPO, CRP
22methacholine45 51 1111.5CRP, MPO
23gabexate mesilate459.4F5, CRP
24convulxin459.4CRP, F5
25tibolone459.4F5, CRP
26clozapine45 29 51 1112.4CRP, MPO
27vitamin b6459.4CRP, F5
28prednisolone45 29 1111.3CRP, MPO
29metformin45 51 1111.3F5, CRP
30uric acid45 2410.3F5, CRP
31homocysteine45 2410.3F5, CRP
32p002459.3CRP, F5
33atorvastatin45 51 29 24 1113.2F5, CRP
34citrate459.2CRP, F5
35simvastatin45 51 61 29 24 1114.1F5, CRP
36endotoxin459.1F5, CRP
37folate459.0F5, CRP
38chloramphenicol45 3 51 1112.0CRP, LACTB, MPO
39ceftriaxone45 1110.0F5, CRP, LACTB
40vitamin b12459.0F5, CRP, MPO
41malondialdehyde459.0MPO, CRP, F5
42polyethylene glycol459.0F5, CRP, MPO
43cyclophosphamide45 51 1110.9MPO, CRP, F5
44prostacyclin458.9CRP, F5
45ascorbic acid45 249.9F5, CRP, MPO
46lactate458.9F5, CRP, MPO
47creatinine458.9F5, CRP, MPO
48serine458.8F5, LACTB, MPO
49vegf458.8MPO, CRP, F5
50aspirin45 51 29 2411.7F5, CRP

GO Terms for genes affiliated with Mediastinitis

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16Gene Ontology
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Cellular components related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5F5, CRP, MPO

Biological processes related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1agingGO:0075689.1CRP, MPO

Products for genes affiliated with Mediastinitis

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Sources for Mediastinitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet