MCID: MDS022
MIFTS: 46

Mediastinitis malady

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Summaries for Mediastinitis

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Wikipedia:65 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

MalaCards based summary: Mediastinitis is related to pancreatitis and tuberculosis. An important gene associated with Mediastinitis is MPO (myeloperoxidase), and among its related pathways is Selenium Pathway. The compounds cefdinir and cefaclor have been mentioned in the context of this disorder. Affiliated tissues include b cells, lymph node and lung.

Aliases & Classifications for Mediastinitis

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Mediastinitis, Aliases & Descriptions:

Name: Mediastinitis 8 10 62


External Ids:

Disease Ontology8 DOID:819
ICD9CM27 519.2
SNOMED-CT57 47597000
MeSH34 D008480
NCIt39 C26827

Related Diseases for Mediastinitis

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Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to mediastinitis

Symptoms for Mediastinitis

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Drugs & Therapeutics for Mediastinitis

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Drug clinical trials:

Search ClinicalTrials for Mediastinitis

Search NIH Clinical Center for Mediastinitis

Genetic Tests for Mediastinitis

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Anatomical Context for Mediastinitis

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MalaCards organs/tissues related to Mediastinitis:

32
B cells, Lymph node, Lung, Heart, Thyroid, Myeloid, Bone, T cells, Liver, Breast, Skin, Colon, Tonsil, Bone marrow, Thymus, Spinal cord, Trachea, Spleen, Brain, Adipocyte, Kidney, Pancreas, Ovary, Prostate, Testes, Monocytes, Pituitary

Animal Models for Mediastinitis or affiliated genes

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Publications for Mediastinitis

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Articles related to Mediastinitis:

(show top 50)    (show all 1788)
idTitleAuthorsYear
1
Brown tumor in a patient with ectopic mediastinal parathyroid adenoma: A case report. (25408600)
2014
2
Invited Commentary on the Paper Entitled 'Methicillin-Resistant Staphylococcus aureus Infection: An Independent Risk Factor for Mortality in Patients with Poststernotomy Mediastinitis'. (25115576)
2014
3
Successful excision of a giant mediastinal vagal schwannoma causing severe tracheal stenosis through a median sternotomy. (24996720)
2014
4
Clinical utility and economic impact of conventional transbronchial needle aspiration of mediastinal lymphadenopathies in bronchogenic carcinoma. (23083635)
2013
5
Mediastinal goiter presenting with ventricular tachycardia. (22302698)
2013
6
Mediastinal hemangioma: Masquerading as pleural effusion. (24347874)
2013
7
Zygomycotic Mediastinal Lymphadenitis in Beef Cattle with Ruminal Tympany. (24018826)
2013
8
Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene. (23457195)
2013
9
Embryonal rhabdomyosarcoma arising from a mediastinal teratoma: an unusual case report. (23487585)
2013
10
Probable initial pulmonary lymphangioleiomyomatosis and mediastinal lymphangioleiomyoma. (24268918)
2013
11
A mediastinal liposarcoma resected using a double approach with a thoracoscope. (25360414)
2013
12
Isolated mediastinal amyloidosis mimicking a neoplastic lesion. (23585190)
2013
13
Mediastinitis: mortality rate comparing single-stage surgical approach and preconditioning of wound. (23939316)
2013
14
Mediastinal lymphangioma treated using endobronchial ultrasound-guided transbronchial needle aspiration. (23018866)
2012
15
Fibrosing mediastinitis as a cause of right claudication. (21562863)
2012
16
Combined spontaneous contralateral pneumothorax and post-pneumonectomy mediastinal shift-associated dextrocardia. (21243579)
2011
17
Mediastinal epithelioid hemangioendothelioma mimicking a teratoma. (21492982)
2011
18
Isolated mediastinal myeloid sarcoma successfully treated with chemoradiotherapy followed by unrelated allogeneic stem cell transplantation. (22185993)
2011
19
An aortic root pseudoaneurysm that developed after implantation of a rectus abdominis muscle flap to treat an MRSA mediastinitis: a case report. (20190716)
2010
20
Two cases of mediastinal gray zone lymphoma. (21123972)
2010
21
Images for surgeons. A case of matured mediastinal teratoma complicated by cardiac tamponade: an unusual aetiology. (21061752)
2010
22
Iniencephaly with mediastinal bronchogenic cyst: A case report. (22439066)
2010
23
Severe deep neck space infections and mediastinitis of odontogenic origin: clinical relevance and implications for diagnosis and treatment. (18607917)
2009
24
The role of omental transposition for the management of postoperative mediastinitis: a case series. (19236690)
2009
25
Mediastinal solitary fibrous tumor with right diaphragm invasion: report of a case. (19319642)
2009
26
Multidrug-resistant Klebsiella pneumoniae mediastinitis safely and effectively treated with prolonged administration of tigecycline. (18540810)
2008
27
Mediastinal lymphatic drainage from pulmonary lobe based on CT observations of histoplasmosis: implications for minimal N2 disease of non-small-cell lung cancer. (17952543)
2007
28
High expression of several tyrosine kinases and activation of the PI3K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma. (17375124)
2007
29
Sigmoid colon cancer with mediastinal lymph node metastases. (18050829)
2007
30
Cold agglutinin disease revealing mediastinal seminoma. (17449873)
2007
31
Acute suppurative thyroiditis extending to descending necrotizing mediastinitis and pericarditis. (17381365)
2007
32
Mediastinal Castleman disease mimicking mediastinal pulmonary sequestration. (16077341)
2005
33
Acute mediastinitis resulting from an unsuspected fish bone--case report. (15875620)
2005
34
Calcified metastatic mediastinal lymph nodes from mucinous breast adenocarcinoma. (14566424)
2004
35
Congenital diaphragmatic eventration as a cause of anterior mediastinal mass in the children: imaging modalities and literature review. (15186890)
2004
36
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. (15377470)
2004
37
Cushing's syndrome with mediastinal lipomatosis. (15322612)
2004
38
Usefulness of routine epicardial pacing wire culture for early prediction of poststernotomy mediastinitis. (15528721)
2004
39
Pathobiology of primary mediastinal B-cell lymphoma. (15202521)
2003
40
Role of radiation therapy in the management of primary mediastinal large B-cell lymphoma (PMLBL). (12553345)
2002
41
Expression of hMLH1 and hMSH2 and assessment of microsatellite instability in testicular and mediastinal germ cell tumours. (11719586)
2001
42
Acute mediastinitis. (16389322)
2000
43
Preoperative embolization in surgical treatment of mediastinal hemangiopericytoma. (10750792)
2000
44
Posterior mediastinal capillary hemangioma with extradural extension resembling neuroblastoma. (10398787)
1999
45
Transcription of the nude gene (WHN) in human normal organs and mediastinal and pulmonary tumors. (10483588)
1999
46
Mediastinal bronchogenic cyst manifesting as a catastrophic myocardial infarction. (10391298)
1999
47
A patient with a relapse of myasthenia gravis after a 13-year remission following successful treatment by mediastinal irradiation and corticosteroid therapy]. (7605688)
1995
48
MEN type 1 associated with mediastinal carcinoid producing parathyroid hormone, calcitonin and chorionic gonadotropin. (7905624)
1993
49
Mediastinal mass with acute leukemia. Myeloblastoma masquerading as lymphoblastic lymphoma. (6937159)
1981
50
Mediastinal extramedullary plasmacytoma. (7375991)
1980

Variations for Mediastinitis

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Expression for genes affiliated with Mediastinitis

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Expression patterns in normal tissues for genes affiliated with Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Pathways for genes affiliated with Mediastinitis

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Pathways related to Mediastinitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway37
9.1CRP, MPO

Compounds for genes affiliated with Mediastinitis

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Compounds related to Mediastinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1cefdinir44 1110.9MPO, LACTB
2cefaclor44 1110.9LACTB, MPO
3ampicillin44 1110.8LACTB, MPO
4linezolid44 1110.8F5, LACTB
5nafamostat mesilate449.8F5, MPO
6cefotaxime44 1110.8F5, LACTB
7vancomycin44 1110.8LACTB, F5
8bivalirudin44 1110.8MPO, F5
9taurine chloramine449.7MPO, F5
10erythromycin44 2 50 1112.7MPO, LACTB
11ofloxacin44 2 1111.7LACTB, F5
12penicillin449.7F5, LACTB
13ciprofloxacin44 50 1111.7LACTB, F5
14fluorescein44 1110.7F5, MPO
15dextran sulfate449.7F5, MPO
16kininogen449.6F5, MPO
17aopp449.6CRP, MPO
18azithromycin44 1110.5LACTB, CRP
19d penicillamine449.5CRP, MPO
20sulfasalazine28 44 50 1112.5CRP, MPO
218-isoprostane449.5MPO, CRP
22methacholine44 50 1111.5CRP, MPO
23gabexate mesilate449.4F5, CRP
24convulxin449.4CRP, F5
25tibolone449.4F5, CRP
26clozapine44 28 50 1112.4CRP, MPO
27vitamin b6449.4CRP, F5
28prednisolone44 28 1111.3CRP, MPO
29metformin44 50 1111.3F5, CRP
30uric acid44 2410.3F5, CRP
31homocysteine44 2410.3F5, CRP
32p002449.3CRP, F5
33atorvastatin44 50 28 24 1113.2F5, CRP
34citrate449.2CRP, F5
35simvastatin44 50 61 28 24 1114.1F5, CRP
36endotoxin449.1F5, CRP
37folate449.0F5, CRP
38chloramphenicol44 2 50 1112.0CRP, LACTB, MPO
39ceftriaxone44 1110.0F5, CRP, LACTB
40vitamin b12449.0F5, CRP, MPO
41malondialdehyde449.0MPO, CRP, F5
42polyethylene glycol449.0F5, CRP, MPO
43cyclophosphamide44 50 1110.9MPO, CRP, F5
44prostacyclin448.9CRP, F5
45ascorbic acid44 249.9F5, CRP, MPO
46lactate448.9F5, CRP, MPO
47creatinine448.9F5, CRP, MPO
48serine448.8F5, LACTB, MPO
49vegf448.8MPO, CRP, F5
50aspirin44 50 28 2411.7F5, CRP

GO Terms for genes affiliated with Mediastinitis

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Cellular components related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5F5, CRP, MPO

Biological processes related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1agingGO:0075689.1CRP, MPO

Products for genes affiliated with Mediastinitis

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Sources for Mediastinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet