Aliases & Classifications for Mediastinitis

MalaCards integrated aliases for Mediastinitis:

Name: Mediastinitis 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:819
ICD10 32 J98.5
ICD9CM 34 519.2
MeSH 41 D008480
NCIt 46 C26827
SNOMED-CT 64 47597000
UMLS 69 C0025064

Summaries for Mediastinitis

MalaCards based summary : Mediastinitis is related to pleural disease and diaphragmatic eventration, and has symptoms including signs and symptoms and chest pain. An important gene associated with Mediastinitis is MPO (Myeloperoxidase), and among its related pathways/superpathways is Selenium Micronutrient Network. The drugs Clopidogrel and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include b cells, lymph node and lung, and related phenotypes are Increased shRNA abundance and cardiovascular system

Wikipedia : 72 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

Related Diseases for Mediastinitis

Diseases related to Mediastinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 610)
# Related Disease Score Top Affiliating Genes
1 pleural disease 29.5 CRP MPO
2 diaphragmatic eventration 29.4 NKX2-6 TEF
3 pulmonary embolism 29.3 CRP F5
4 myocardial infarction 28.9 CRP F5 INS MPO
5 aortitis 28.7 CRP MPO RERE
6 fibrosing mediastinitis 12.4
7 primary mediastinal large b-cell lymphoma 12.2
8 mediastinal cancer 12.1
9 malignant mediastinal neurogenic neoplasm 12.0
10 mediastinal lipomatosis 12.0
11 mediastinal gray zone lymphoma 12.0
12 mediastinal malignant lymphoma 12.0
13 mediastinal granular cell myoblastoma 12.0
14 mediastinal endodermal sinus tumors 12.0
15 benign mediastinal neurilemmoma 12.0
16 mediastinal neurilemmoma 12.0
17 childhood mediastinal neurogenic tumor 11.8
18 mediastinal osteogenic sarcoma 11.8
19 mediastinal melanocytic neurilemmoma 11.8
20 benign mediastinal psammomatous neurilemmoma 11.8
21 mediastinal mesenchymal tumor 11.8
22 gray zone lymphoma 11.2
23 igg4-related disease 11.1
24 fibrosclerosis, multifocal 11.1
25 lipomatosis, multiple symmetric 10.9
26 pagod syndrome 10.9
27 anemia, congenital dyserythropoietic, type ii 10.9
28 carney triad 10.9
29 mediastinum neuroblastoma 10.9
30 mediastinum sarcoma 10.9
31 malignant melanocytic peripheral nerve sheath tumor of mediastinum 10.8
32 lymphoma 10.6
33 b-cell lymphomas 10.5
34 teratoma 10.4
35 mononeuritis multiplex 10.4 CRP MPO
36 rapidly progressive glomerulonephritis 10.3 CRP MPO
37 acquired angioedema 10.3 CRP F5
38 hypersensitivity vasculitis 10.3 CRP MPO
39 pulmonary aspergilloma 10.3 CRP MPO
40 hypersensitivity reaction type iii disease 10.3 CRP MPO
41 adenoma 10.3
42 parathyroid adenoma 10.3
43 peripheral vertigo 10.3 CRP F5
44 polyarteritis nodosa 10.3 CRP MPO
45 proctitis 10.3 CRP MPO
46 multiple cranial nerve palsy 10.3 CRP MPO
47 suppurative cholangitis 10.3 CRP MPO
48 pleurisy 10.3 CRP MPO
49 appendicitis 10.3 CRP MPO
50 idiopathic edema 10.2 INS MPO

Comorbidity relations with Mediastinitis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to Mediastinitis

Symptoms & Phenotypes for Mediastinitis

UMLS symptoms related to Mediastinitis:


signs and symptoms, chest pain

GenomeRNAi Phenotypes related to Mediastinitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 F5 INS RERE

MGI Mouse Phenotypes related to Mediastinitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 RERE CRP DNM1 F5 INS MPO
2 embryo MP:0005380 9.55 F5 INS MAPKAPK3 NKX2-6 RERE
3 homeostasis/metabolism MP:0005376 9.5 CRP DNM1 F5 INS MPO NKX2-6
4 mortality/aging MP:0010768 9.23 DNM1 F5 INS MAPKAPK3 MPO NKX2-6

Drugs & Therapeutics for Mediastinitis

Drugs for Mediastinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
2
Ticlopidine Approved Phase 4 55142-85-3 5472
3
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
4 tannic acid Approved, Nutraceutical Phase 4
5 Coagulants Phase 4
6 Hemostatics Phase 4
7 Fibrinolytic Agents Phase 4
8 Neurotransmitter Agents Phase 4
9 Cytochrome P-450 Enzyme Inhibitors Phase 4
10 Platelet Aggregation Inhibitors Phase 4
11 Purinergic P2 Receptor Antagonists Phase 4
12 Purinergic P2Y Receptor Antagonists Phase 4
13 insulin Phase 4
14 Hypoglycemic Agents Phase 4
15 Insulin, Globin Zinc Phase 4
16
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
17
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
18 Prednisolone acetate Phase 3
19 glucocorticoids Phase 3
20 Methylprednisolone acetate Phase 3
21 Methylprednisolone Hemisuccinate Phase 3
22 Gastrointestinal Agents Phase 3
23 Neuroprotective Agents Phase 3
24 Hormone Antagonists Phase 3
25 Hormones Phase 3
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
27 Peripheral Nervous System Agents Phase 3
28 Antiemetics Phase 3
29 Prednisolone hemisuccinate Phase 3
30 Prednisolone phosphate Phase 3
31 Anti-Inflammatory Agents Phase 3
32 Protective Agents Phase 3
33 Antineoplastic Agents, Hormonal Phase 3
34 Autonomic Agents Phase 3
35 Vaccines Phase 2, Phase 3
36
Vancomycin Approved 1404-90-6 14969 441141
37
Cefuroxime Approved 55268-75-2 5479529 5361202
38 Anti-Bacterial Agents
39 Antibiotics, Antitubercular
40 methicillin
41 cefuroxime axetil
42 Anti-Infective Agents

Interventional clinical trials:

(show all 23)

# Name Status NCT ID Phase Drugs
1 Improvement of Hemostasis Techniques After Median Sternotomy Unknown status NCT01134471 Phase 4
2 Rapid Sternal Closure System (TALON) Completed NCT00638014 Phase 4
3 Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery. Completed NCT00724880 Phase 4 Clopidogrel;Clopidogrel;Clopidogrel
4 Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery Terminated NCT00394303 Phase 4 Intraoperative continuous insulin infusion
5 SOLAR & ATRILAZE Atrial Fibrillation Trial Unknown status NCT00734058 Phase 3
6 STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery Recruiting NCT03229538 Phase 3 Methylprednisolone;Isotonic saline
7 Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2) Terminated NCT00518687 Phase 2, Phase 3
8 The eMESH 1 Feasibility Study Recruiting NCT01676376 Phase 1, Phase 2
9 Delayed Primary Versus Late Secondary Wound Closure in Sternum Infections Unknown status NCT01473979
10 Endoscopic-vacuum Assisted Closure of Intrathoracic Postsurgical Leaks Unknown status NCT00876551
11 Intra-aortic Balloon Counterpulsation in Patients Undergoing Cardiac Surgery Unknown status NCT02143544
12 Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft Completed NCT00711685
13 Physiotherapy Exercises in Patients With Sternal Instability After Cardiovascular Surgery Completed NCT02513576
14 Evaluation of Primary Plating in Sternotomy Patients for Osteosynthesis and Pain Completed NCT00819286
15 Perioperative Intra-Aortic Balloon Pump (IABP) in Coronary Artery Bypass Grafting (CABG) Operations in Patients With Severely Depressed Left Ventricular Function Completed NCT00881192
16 Pharmacokinetics of Cefuroxime in Cardiac Surgery With Cardiopulmonary Bypass Completed NCT01228825
17 Mediastinitis and Staphylococcus Aureus Recruiting NCT03262558
18 Factors Associated With Complications of Cervical Necrotizing Fasciitis Recruiting NCT02847234
19 Study of the Combined Influence of Sepsis and Mechanical Ventilation on the Human Diaphragm Recruiting NCT03371602
20 Registry for the Improvement of Postoperative OutcomeS in Cardiac and Thoracic surgEry Recruiting NCT03209674
21 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2 Active, not recruiting NCT02073760
22 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery Active, not recruiting NCT02068716
23 Effects of a New Antimicrobial Dressing on Wound Healing and Incidence of Sternal Wound Infections Terminated NCT00203541

Search NIH Clinical Center for Mediastinitis

Cochrane evidence based reviews: mediastinitis

Genetic Tests for Mediastinitis

Anatomical Context for Mediastinitis

MalaCards organs/tissues related to Mediastinitis:

38
B Cells, Lymph Node, Lung, Heart, Thyroid, Myeloid, T Cells

Publications for Mediastinitis

Articles related to Mediastinitis:

(show top 50) (show all 2225)
# Title Authors Year
1
Extended surgery using anterior mediastinal tracheostomy for recurrent mediastinal liposarcoma. ( 29415198 )
2018
2
Near-infrared intraoperative imaging during resection of an anterior mediastinal soft tissue sarcoma. ( 29387401 )
2018
3
A Migratory Mishap: Giant Mediastinal Parathyroid Adenoma. ( 29360437 )
2018
4
Med-Score 24: A multivariable prediction model for poststernotomy mediastinitis 24A hours after admission to the intensive care unit. ( 29273422 )
2018
5
Fibrosing mediastinitis with pulmonary hypertension as a complication of pulmonary vein stenosis: A case report and review of the literature. ( 29369193 )
2018
6
Endovascular Management of SVC Syndrome due to Fibrosing Mediastinitis-A Feasibility and Safety Analysis. ( 29433409 )
2018
7
SurgicelAr packing remnants mimicking mediastinitis after adult cardiac surgery. ( 29365109 )
2018
8
Curious case of a black pleural effusion: Mediastinal teratoma presenting as massive pleural effusion. ( 29319045 )
2018
9
Study of the radiologic features of Legionnaires' disease with mediastinal adenopathy: Legionella or lymphoma? ( 29383455 )
2018
10
Effect of chlorhexidine skin disinfection and retrosternal gentamicin sponge on post-sternotomy mediastinitis: results from a prospective controlled registry of 2340 patients. ( 29409978 )
2018
11
Dieulafoy's disease with mediastinal arteriovenous malformation. ( 29353256 )
2018
12
Poststernotomy mediastinitis: Early risk factors identified but hard to modify. ( 29113644 )
2018
13
Core Needle Biopsy of an Anterior Mediastinal Thymoma: Creation of a Safe Access Route by Hydrodissection. ( 29373145 )
2018
14
Percutaneous therapy of a mediastinal lymphangioma with fibrin glue: case report with clinical success after 4A years. ( 29361923 )
2018
15
Mediastinal lymphangioma in an adult. ( 29397964 )
2018
16
Expression pattern of PD-L1 and PD-L2 in classical Hodgkin lymphoma, primary mediastinal large B-cell lymphoma, and gray zone lymphoma. ( 29377256 )
2018
17
Primary mediastinal large B-cell lymphoma: Outcome of a series of pediatric patients treated with high-dose methotrexate and cytarabine plus anti-CD20. ( 29049862 )
2018
18
Clinical and imaging spectrum of tuberculosis-associated fibrosing mediastinitis. ( 29356415 )
2018
19
Mediastinal cystic mass as atypical location of visceral leishmaniasis. ( 29398008 )
2018
20
Interim FDG PET/CT in primary mediastinal diffuse large B-cell lymphoma: really almost useless procedure? ( 29397402 )
2018
21
Extracorporeal Membrane Oxygenation (ECMO)-Assisted Surgery for Mediastinal Goiter Removal. ( 29242007 )
2018
22
Bronchoscopic Management of Airway Compression due to Fibrosing Mediastinitis. ( 28719233 )
2017
23
Surgical excision is the treatment of choice for cervical lymphatic malformations with mediastinal expansion. ( 29173777 )
2017
24
Chest Necrotizing Fasciitis with Mediastinitis. ( 28674375 )
2017
25
Mediastinal syndrome from plasmablastic lymphoma in human immunodeficiency virus and human herpes virus 8 negative patient with polycythemia vera: a case report. ( 28320457 )
2017
26
Giant Cervical Goiter With Posterior Mediastinal Extension. ( 28929034 )
2017
27
Primary mediastinal seminoma presenting with superior vena caval obstruction. ( 28855218 )
2017
28
Solitary mediastinal angiomatosis: report of two cases and review of the literature. ( 29256416 )
2017
29
Predictors of Mediastinitis Risk after Coronary Artery Bypass Surgery: Applicability of Score in 1.322 Cases. ( 28832745 )
2017
30
Superior Vena Cava Syndrome Due to Mediastinal Tuberculous Lymphadenitis. ( 28572894 )
2017
31
Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association. ( 27758822 )
2017
32
Mediastinal cyst of mA1llerian origin: evidence for developmental endosalpingiosis. ( 27913049 )
2017
33
Pulmonary hypertension associated with combined fibrosing mediastinitis and bronchial anthracofibrosis: A retrospective analysis in a single Chinese hospital. ( 28419740 )
2017
34
An unusual case of sudden unexpected death due to massive hemopericardium from primary mediastinal seminoma. ( 28341006 )
2017
35
Dendritic Cell Markers and PD-L1 are Expressed in Mediastinal Gray Zone Lymphoma. ( 29189264 )
2017
36
Complete thoracoscopic excision of an infected bronchogenic cyst due to mediastinitis. ( 29268552 )
2017
37
Mediastinal seminoma presenting with superior vena cava syndrome. ( 28596199 )
2017
38
Mycobacterium kansasii Pneumonia with Mediastinal Lymphadenitis in a Patient with Acute Myeloid Leukemia: Successful Treatment to Stem Cell Transplantation. ( 28271647 )
2017
39
PD-1 Blockade in Mediastinal Gray-Zone Lymphoma. ( 28679093 )
2017
40
Safety and tolerability of pembrolizumab in patients with relapsed/refractory primary mediastinal large B-cell lymphoma. ( 28490569 )
2017
41
Concomitant occurrence of primary hyperparathyroidism (PHPT) due to mediastinal parathyroid adenoma and sublingual thyroid gland: the role of parathyroid technetium-99m-MIBI scintigraphy. ( 29152292 )
2017
42
Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma. ( 27879516 )
2017
43
Risk factors for delayed oral dietary intake in patients with deep neck infections including descending necrotizing mediastinitis. ( 28825131 )
2017
44
IgG4-Related Sclerosing Mediastinitis: Report of a Case with Distinct Ultrasound Findings. ( 28845480 )
2017
45
Complete response of mediastinal clear cell sarcoma to pembrolizumab with radiotherapy. ( 28725344 )
2017
46
Coexistence of Mediastinal Castleman Disease with Spindle Cell Carcinoma of the Lung. ( 28661181 )
2017
47
Primary mediastinal large B-cell lymphoma. ( 28318892 )
2017
48
Massive mediastinal enlargement due to extramedullary haematopoiesis in a patient with MYH9-related thrombocytopenia. ( 28516481 )
2017
49
Multinodular esophageal leiomyomatosis: An uncommon cause of mediastinal mass. ( 29033067 )
2017
50
Pleural and Mediastinal Lipomatosis with Subpleural Fat as a Mimicker of Pleural Effusion- A Rare Case Report. ( 28893005 )
2017

Variations for Mediastinitis

Expression for Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Pathways for Mediastinitis

Pathways related to Mediastinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 CRP INS MPO

GO Terms for Mediastinitis

Cellular components related to Mediastinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 8.62 F5 INS

Biological processes related to Mediastinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.96 CRP INS
2 negative regulation of blood vessel diameter GO:0097756 8.62 CRP INS

Sources for Mediastinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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