Search MalaCards:
MCID: MDS022

Mediastinitis malady
116 genes, 11 tissues, 915 related diseases, 24 phenotypes, 116 articles, clinical trials.

Summaries for Mediastinitis

about this section
Sources:
44Wikipedia, 22MalaCards
See all sources

Export this MalaCard
Wikipedia: Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or...44 more...

MalaCards: Mediastinitis, also known as mediastinitis (disorder), is related to b-cell lymphomas and hodgkin's lymphoma. An important gene associated with Mediastinitis is AFP (alpha-fetoprotein), and among its related pathways are EGFR Inhibitor Pathway, Pharmacodynamics and ErbB2-ErbB3 Heterodimers. The compounds glucose and dmso have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and liver, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Aliases & Descriptions for Mediastinitis

about this section
Sources:
6Disease Ontology, 8DISEASES, 43UMLS, 40SNOMED-CT, 24MeSH, 19ICD9CM, 27NCIt
See all sources

Aliases & Descriptions:

mediastinitis 6 8 43
mediastinitis (disorder) 6

External Ids:

ICD9CM19 519.2
SNOMED-CT40 47597000

Related Diseases for Mediastinitis

about this section
Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to mediastinitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 912)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas32.4REL, MYC, CLU, PAX5, BCL6, BCR
2hodgkin's lymphoma29.5PIK3CG, REL, PAX5, BCL6, BCR, CHRDL1
3dendritic cell sarcoma28.2VIM, CLU, CD68, FCER2, IL2RA, TP53
4germ cell tumor28.1KIT, PCNA, CGA, CGB, MLH1, MLL
5teratoma28.1KIT, PCNA, VIM, CGA, CGB, JUN
6primary hyperparathyroidism27.6PAX5, ALPP, CALCA, PTH
7neuroendocrine tumor27.6SDHD, CEACAM3, ENO2, CALCA, SST, KRT19
8rosai-dorfman disease27.3S100A1, CD163, F3, ALPP, CRP
9lymphoblastic lymphoma27.3PAX5, BCL6, MPO, MLL, ENO2, TRB@
10chronic granulomatous disease27.2MPO, AKT1, CYBB, ADA
11klebsiella27.2LACTB, MPO, CD79A, IL1R1, CSF3
12hemangioendothelioma27.0IFNA2, CALB2, CRP, PGR, AFP
13follicular lymphoma27.0REL, MYC, MYB, PAX5, BCL6, BCR
14seminoma26.9KIT, SELE, VIM, VEGFC, MYC, CHKB
15follicular dendritic cell sarcoma26.8VIM, CLU, FCER2, IL2RA, TP53
16klinefelter's syndrome26.7CGA, CGB, IL6, F5, CRP, EPO
17non-small cell lung carcinoma26.3PCNA, VEGFC, MYC, JUN, ENO2, TP53
18myxoma26.3KIT, VIM, S100A1, IL6, CALB2, AKT1
19thymic carcinoma25.8KIT, VIM, VEGFC, S100A1, CEACAM3, CD5
20pulmonary sarcoidosis25.5IL2RA, IL4, IL6, CCL5, TRB@, PTPRC
21chordoma25.4VIM, S100A1, CEACAM3, AKT1, TP53, PLAU
22emphysema25.1PCNA, SDHB, MPO, MLLT10, IL13, CALCA
23t-cell leukemia25.0PIK3CG, REL, MYC, MYB, JUN, FCER2
24carcinoid tumors25.0PCNA, SDHD, CGA, CGB, CEACAM3, ENO2
25immunodeficiency24.9BCR, CD79A, CD274, IL13, IL2RA, IL4
26hypercalcemia24.8VIM, IL6, ALPP, ALPPL2, CALCA, PTH
27sepsis24.5SELE, LACTB, MPO, CD163, IL1R1, IL6
28common variable immunodeficiency24.5BCL6, MPO, CD79A, IL1R1, IL2RA, IL4
29choriocarcinoma24.3PIK3CG, PCNA, MYC, CGA, CGB, JUN
30cushing's syndrome24.3PCNA, CGA, IL2RA, IL6, ENO2, CALCA
31diffuse large b-cell lymphoma24.3PIK3CG, REL, KIT, SELE, VEGFC, MYC
32pulmonary tuberculosis24.2CD79A, CD5, IL13, IL1R1, IL2RA, IL4
33chronic myeloid leukemia24.0PIK3CG, KIT, MYC, MYB, BCR, MPO
34lung carcinoma24.0PIK3CG, PCNA, VEGFC, MYC, MYB, BCR
35paraganglioma23.9KIT, PCNA, VIM, SDHB, SDHD, S100A1
36malignant pleural mesothelioma23.6KIT, VIM, CEACAM3, IL6, IFNA2, CALB2
37hemangioma23.3SELE, MYC, CLU, SDHB, SDHD, CEACAM3
38monocytic leukemia23.3VIM, MYC, MPO, JUN, MLL, MLLT10
39angiomyolipoma23.0KIT, VIM, MYC, S100A1, CD68, IL6
40tuberous sclerosis22.8PIK3CG, PCNA, VIM, MYC, AKT1, ESR1
41sarcoidosis22.2SELE, VIM, CD79A, CD68, FCER2, IL13
42hyperparathyroidism22.1PCNA, SELE, PAX5, SDHB, SDHD, IL2RA
43pheochromocytoma21.5KIT, MYC, SDHB, SDHD, S100A1, JUN
44graves' disease19.9SELE, MYC, CHKB, CGA, MPO, CD79A
45tuberculosis18.8PIK3CG, VIM, SDHB, SDHD, LACTB, CGB
46pneumonia18.7SELE, VIM, VEGFC, BCL6, CHKB, LACTB
47noonan syndrome18.4PIK3CG, PCNA, CLU, CHKB, S100A1, MPO
48thyroid carcinoma18.1PIK3CG, PCNA, SELE, VIM, VEGFC, MYC
49adenoma16.2KIT, PCNA, VIM, VEGFC, MYC, MYB
50sarcoma15.2PIK3CG, KIT, PCNA, SELE, VIM, VEGFC

Graphical network of the top 20 diseases related to mediastinitis:



Graphical network of diseases related to mediastinitis

Clinical Features for Mediastinitis

about this section

Drugs & Therapeutics for Mediastinitis

about this section
Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for mediastinitis

Drug clinical trials:

Search ClinicalTrials for mediastinitis

Search NIH Clinical Center for mediastinitis

Search CenterWatch for mediastinitis

Genetic Tests for Mediastinitis

about this section

Anatomical Context for Mediastinitis

about this section
Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to mediastinitis:

22
Bone marrow, Lymph node, Liver, Lung, Thyroid, Breast, Myeloid, Monocytes, T cells, B lymphoblasts, B cells

Phenotypes for genes affiliated with Mediastinitis

about this section
Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to mediastinitis:

25 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:000537910.6AFP, NKX2-1, PTH, AMPH, FOXN1
2respiratory system phenotypeMP:000538810.2ADA, ADORA1, POU2F2, STAT6, CRH, CYSLTR1
3reproductive system phenotypeMP:00053898.5PTPN11, KRT19, TSC1, TSHR, TCL1A, STAT6
4embryogenesis phenotypeMP:00053808.3CCNE1, ALPP, PTPN11, KRT19, EGFR, NME1
5renal/urinary system phenotypeMP:00053678.2EGFR, TSC1, SOCS1, POU2AF1, LYN, ADORA1
6digestive/alimentary phenotypeMP:00053817.5CYBB, SST, PLAU, KRT19, EGFR, STAT1
7liver/biliary system phenotypeMP:00053707.3EPO, IL1R1, IL6, FABP3, AKT1, TRB@
8vision/eye phenotypeMP:00053917.2F3, TP53, PTPN11, SPI1, PLAU, EGFR
9hearing/vestibular/ear phenotypeMP:00053777.2PLAU, NFKB1, EGFR, ABCB1, TSHR, DNM1
10nervous system phenotypeMP:00036317.0REL, RERE, KIT, MYC, PAX5, SPI1
11integument phenotypeMP:00107716.6MYB, CD274, FOXN1, MLH1, MLL, IL13
12behavior/neurological phenotypeMP:00053866.2PLAUR, SST, CYBB, PTGDS, AKT1, CALCA
13tumorigenesisMP:00020066.0KIT, MYC, PTPRC, CYBB, SPI1, PLAU
14mortality/agingMP:00107685.4PTPN11, NKX2-1, LYN, ADA, AFP, NME1
15skeleton phenotypeMP:00053905.4TNFAIP3, PTH, PTPN11, PTPRC, SPI1, PLAU
16muscle phenotypeMP:00053695.3ESR1, TP53, PTPN11, CYBB, PLAU, PLAUR
17growth/size phenotypeMP:00053785.1F3, EGFR, TSC1, TSHR, STAT6, STAT1
18cardiovascular system phenotypeMP:00053853.0RERE, FABP3, CCNE1, F5, F3, CALCA
19homeostasis/metabolism phenotypeMP:00053762.0EGFR, ADA, EPO, AFP, ADORA1, LYN
20cellular phenotypeMP:0005384INFPIK3CG, REL, KIT, PCNA, SELE, VIM
21hematopoietic system phenotypeMP:0005397INFKIT, PCNA, BLNK, BCL11A, CD274,
22no phenotypic analysisMP:0003012INFTNFAIP3, PTPN11, SST, SPI1, KRT19, EGFR
23immune system phenotypeMP:0005387INFREL, PTGDS, PTPN11, PTPRC, CYSLTR1, CYBB
24normal phenotypeMP:0002873INFJAK2, CD79A, , FOXN1, GRB2, IL4

Publications for genes affiliated with Mediastinitis

about this section
Sources:
35PubMed
See all sources

Articles related to mediastinitis:

(show top 50)    (show all 116)
idTitleAuthorsYearAffiliating Genes
1Mediastinal lymphangiomyoma in an adult: Report of a case. (20339992)Ota H.... Ogawa J.2010PGR
2The value of CD23 expression as an additional marker in distinguishing mediastinal (thymic) large B-cell lymphoma from Hodgkin lymph oma. (19223373)Salama M.E.... Perkins S.L.2010FCER2
3T-cell leukemia 1 expression in nodal Epstein-Barr vi rus-negative diffuse large B-cell lymphoma and primary mediastinal B-cell lymph oma. (20382409)Gualco G.... Bacchi C.E.2010TCL1A
4An adolescent with a mediastinal mass, diagnosed with Graves disease and thymic hyperplasia. (20100762)Kubicky R.A.... De Luca F.2010TSHR
5TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. (19380639)Schmitz R.... KA1ppers R.2009TNFAIP3
6No evidence for the JAK2 (V617F) or JAK2 exon 12 muta tions in primary mediastinal large B-cell lymphoma. (19704259)Wu D.... Kutok J.L.2009JAK2
7Recurrent mutations of the STAT6 DNA binding domain i n primary mediastinal B-cell lymphoma. (19423726)Ritz O.... Leroy K.2009STAT6
8Identification of a chemokine receptor profile charac teristic for mediastinal large B-cell lymphoma. (19536742)Rehm A.... HAPpken U.E.2009CCBP2, CCR7, CXCR5
9Primary mediastinal large B-cell lymphoma. (18774728)Martelli M.... Johnson P.2008TP53, MYC, BCL6
10Unusual features of malignant pleural mesothelioma metastatic to the mediastinal lymph nodes. (18301236)Wagner D.... Xu H.2008CALB2, NKX2-1
11Recurrent pure mucinous carcinoma of the breast with mediastinal great vessel invasion: HER-2/neu confers aggressiveness. (18306859)Adair J.D.... Yanish G.2008PGR, ESR1
12Recursive Partitioning Analysis of Mediastinal N2 Lym ph Node Involvement with Selected Biological Markers in Operable Non-small Cell Lung Cancer: A Correlative Study. (19662216)Bozcuk H.... Demircan A.2007ABCB1
13Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma. (17120029)Ikeda J.... Aozasa K.2007VEGFC
14Systematic mediastinal lymphadenectomy does not increase postoperative immune response after major lung resections. (17923413)Szczesny T.J.... OlesiA8ska-GrodA_ A.2007IL6, IL1R1
15Target sequence accessibility limits activation-induced cytidine deaminase activity in primary mediastinal B-cell lymphoma. (17638864)Popov S.W.... Leithauser F.2007AICDA
16Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma. (16871282)Weniger M.A.... Barth T.F.2006BCL11A
17Treatment of mediastinal immature teratoma in a child with precocious puberty and Klinefelter's syndrome. (17062277)Chen C.K.... Lee Y.C.2006CGB
18Mediastinal follicular dendritic cell sarcoma involving bone marrow: a case report and review of the literature. (17126255)Jiang L.... Bueso-Ramos C.E.2006VIM, CLU, FCER2
19A case of CD56 positive T-cell lymphoma originating from mediastinal lymph nodes (17233392)Tanigawa M.... Saito K.2006ADA
20Combined therapy of teicoplanin and caffeic acid phenethyl ester (CAPE) in the treatment of experimental mediastinitis in the rat. (17129837)Aytacoglu B.N.... Dikmengil M.2006MPO
21Downregulation of internal enhancer activity contributes to abnormally low immunoglobulin expression in the MedB-1 mediastinal B-cell lymphoma cell line. (15682441)Ritz O.... Wirth T.2005POU2F2
22Expression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma. (15744341)Marafioti T.... Mason D.Y.2005SYK, LYN, PLCG2
23Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line. (15572583)Melzner I.... Moller P.2005JAK2, SOCS1
24Effects of autotransfusion of mediastinal shed blood on biochemical markers of myocardial damage in coronary surgery. (16146460)Pleym H.... Stenseth R.2005FABP3
25Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in MedB-1 mediastinal lymphoma line (18035697)Barth T.F.... Moller P.2005JAK2, SOCS1
26Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma. (15044251)Guiter C.... Castellano F.2004STAT6, IL13
27Mutational analysis of IgVH and BCL-6 genes suggests thymic B-cells origin of mediastinal (thymic) B-cell lymphoma. (15370257)Csernus B.... Matolcsy A.2004BCL6
28Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulins. (12507907)Pileri S.A.... Cavalli F.2003BCL6, SPI1
29Pathobiology of primary mediastinal B-cell lymphoma. (15202521)Pileri S.A.... Cavalli F.2003SPI1, SLC22A2
30Primary mediastinal seminomas: evidence of single and multiple KIT mutations. (12379771)Przygodzki R.M.... O'Leary T.J.2002KIT
31Alteration of chromosome arm 6p is characteristic of primary mediastinal B-cell lymphoma, as identified by genome-wide allelotyping. (11319807)Rigaud G.... Scarpa A.2001MYB
32Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma: evidence for derivation from germinal center B cells? (11688462)de Leval L.... Harris N.L.2001BCL6
33Prognostic significance of proliferative activity in pN2 non-small-cell lung carcinomas and their mediastinal lymph node metastases. (10862203)Fukuse T.... Wada H.2000PCNA
34Alpha-fetoprotein production by pancreatic tumors exhibiting acinar cell differentiation: study of five cases, one arising in a mediastinal teratoma. (10987254)Cingolani N.... Rosai J.2000AFP
35Repeat mediastinal lymph-node dissection for palliation in advanced medullary thyroid carcinoma. (10437616)Machens A.... Dralle H.1999CALCA
36Transcription of the nude gene (WHN) in human normal organs and mediastinal and pulmonary tumors. (10483588)Gattenlohner S.... Marx A.1999FOXN1
37Mediastinal germ-cell tumor associated with AML (M7)--the syndrome of mediastinal germ-cell tumors associated with hematologic neoplasia? (9796404)Kitazume K.... Urabe A.1998MLL
38Primary germ cell tumors of the mediastinum: II. Mediastinal seminomas--a clinicopathologic and immunohistochemical study of 120 cases. (9264352)Moran C.A.... Koss M.N.1997ALPP, CGA
39Application of rearrangements of T cell receptor gene in the diagnosis of mediastinal T-lymphoblastic lymphoma: a case report. (9175304)Change K.E.... Chen P.M.1997DNTT
40The usefulness of cardio-vascular visualization in the localization of mediastinal pheochromocytomas with I-131-MIBG. (8814718)BaA9oA9lu T.... Bertrand A.1996OXA1L
41Common variable immunodeficiency presenting in a girl as lung infiltrates and mediastinal adenopathies leading to severe 'super ior vena caval' syndrome. (8880119)Sacco O.... Rossi G.A.1996CD79A
42Imaging of a mediastinal thymic carcinoid tumor with radiolabeled somatostatin analogue. (8744192)Cadigan D.G.... Ur E.1996SST
43Do neuron-specific enolase levels discriminate between small-cell lung cancer and mediastinal tumors? (8938952)Ebert W.... Drings P.1996ENO2
44Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype. (7718322)Fontanini G.... Bevilacqua G.1995EGFR
45Increased CD45RO expression on T lymphocytes in mediastinal lymph node and pulmonary lesions of patients with pulmonary sarcoidosis. (8137547)Fazel S.B.... Lamb D.1994PTPRC
46Diagnosis of mediastinal neoplasms using mediastinoscopy and CT-guided needle biopsy supported by gene analysis (8515159)Chiba W.... Ikei N.1993TRB@
47Interstitial lattice shadow and mediastinal lymphadenopathy with an elevation of carcinoembryonic antigen in severe pulmonary alveolar proteinosis. (1611200)Usui Y.... Kimula Y.1992CEACAM3
48Primary hyperparathyroidism caused by a mediastinal adenoma with intermittent hypercalcemia and severe bone disease (1343071)Araya A.V.... Gac A.1992PTH
49A case of mediastinal yolk sac tumor successfully treated with chemotherapy and surgery (2348134)Okada S.... Nakada T.1990AFP
50Cushing's syndrome in CRF-producing mediastinal carcinoid (2307101)Gerl H.... Martin H.1990CRH

Expression for genes affiliated with Mediastinitis

about this section
Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Mediastinitis

Pathways for genes affiliated with Mediastinitis

about this section
Sources:
34PharmGKB, 36QIAGEN, 10EMD Millipore, 3Cell Signaling Technology, 41Thomson Reuters, 20KEGG
See all sources

Pathways related to mediastinitis according to GeneDecks:

(show top 50)    (show all 184)
idPathwayScoreTop Affiliating Genes
1EGFR Inhibitor Pathway, Pharmacodynamics3410.8PLCG2
2ErbB2-ErbB3 Heterodimers3610.5STAT1, GRB2
3Signal transduction AKT signaling1010.5REL
4Lymphocyte Signaling310.2LYN, PLCG2, SYK, KIT, BLNK, PAX5
5Fc-Gamma-RIIB Signaling in B-Cells3610.2CD79A, LYN, SYK, BLNK
6Development_EPO-induced Jak-STAT pathway4110.0GRB2, LYN, SOCS1, STAT1, JAK2, MYC
7Fc epsilon RI signaling pathway209.9LYN, IL4, GRB2, PIK3CG
8Development EPO-induced Jak-STAT pathway109.9EPO, MYC, PTPN11, LYN, SOCS1, STAT1
9Immune response IL-4 signaling pathway109.8AKT1, NFKB1, STAT6, IL4, REL, GRB2
10Immune response_IL-4 signaling pathway419.8AKT1, REL, IL4, FCER2, GRB2, NFKB1
11Immune response IL-2 activation and signaling pathway109.8SYK, JUN, PTPN11, AKT1, MYC, REL
12Development PDGF signaling via STATs and NF-kB109.8STAT1, REL, MYC, STAT6, NFKB1, GRB2
13Development_PDGF signaling via STATs and NF-kB419.7NFKB1, REL, MYC, JAK2, GRB2, AKT1
14B cell receptor signaling pathway209.7SYK, LYN, NFKB1, PLCG2, AKT1, GRB2
15Immune response BCR pathway109.7BCL6, NFKB1, SYK, BLNK, LYN, PTPRC
16Immune response_BCR pathway419.7PTPRC, GRB2, LYN, NFKB1, PLCG2, AKT1
17Immune response Fc epsilon RI pathway109.6BLNK, REL, PLCG2, SYK, NFKB1, AKT1
18Immune response NFAT in immune response109.6TRB@, CD79A, AKT1, NFKB1, SYK, LYN
19Immune response_Fc epsilon RI pathway419.6LYN, SYK, NFKB1, PLCG2, GRB2, AKT1
20Development EPO-induced MAPK pathway109.5JUN, LYN, SYK, PLCG2, GRB2, JAK2
21Development_EPO-induced MAPK pathway419.5PIK3CG, JUN, JAK2, GRB2, PLCG2, SYK
22PI3K Signaling in B-Lymphocyte369.4AKT1, PTPRC, LYN, SYK, JUN, NFKB1
23IL-3 Pathway369.4AKT1, NFKB1, GRB2, JAK2, STAT6, STAT1
24Development Prolactin receptor signaling109.4AKT1, JUN, JAK2, SOCS1, STAT1, GRB2
25Development_Prolactin receptor signaling419.4MYC, GRB2, JUN, JAK2, PLCG2, NFKB1
26Osteoclast differentiation209.4PLCG2, SPI1, NFKB1, SYK, STAT1, SOCS1
27Acute myeloid leukemia209.3KIT, PIK3CG, GRB2, AKT1, SPI1, MYC
28Immune response_IL-2 activation and signaling pathway419.3GRB2, JUN, MYC, REL, NFKB1, SYK
29Tyrosine Kinases / Adaptors39.3LYN, KIT, BCR, SYK, IL2RA, VEGFC
30Development_EGFR signaling pathway419.2MYC, GRB2, STAT1, AKT1, EGFR, JUN
31IL-2 Pathway369.2NFKB1, SYK, IL2RA, GRB2, JUN, MYC
32Chronic myeloid leukemia208.9MYC, BCR, AKT1, TP53, PTPN11, PIK3CG
33Jak-STAT signaling pathway208.9SOCS1, IL2RA, STAT6, IL4, IFNA2, AKT1
34Measles208.9IFNA2, JAK2, IL13, IL2RA, IL4, IL6
35Akt Signaling368.9TNFRSF8, TSC1, PIK3CG, IL2RA, KIT, VEGFC
36STAT3 Pathway368.9IL2RA, IL1R1, JAK2, MYC, IL4, IL13
37EGF Pathway368.7MYC, GRB2, STAT1, AKT1, NFKB1, JAK2
38Signal transduction_AKT signaling418.5REL, TSC1, NFKB1, TP53, AKT1, MYC
39Pathways in cancer208.5PIK3CG, MYC, BCR, EGFR, JUN, GRB2
40Endometrial cancer208.5EGFR, PIK3CG, MYC, MLH1, GRB2, AKT1
41p70S6K Signaling368.2IL2RA, IL6, GRB2, JAK2, VEGFC, LYN
42Tec Kinases Signaling368.1TNFRSF8, IL13, IL1R1, IL2RA, IL4, IL6
43NFAT in Immune Response368.0JUN, CD79A, IL6, BLNK, KIT, VEGFC
44Cytokine-cytokine receptor interaction208.0IL1R1, IL2RA, CCR7, IL6, IL4, IL13
45Pancreatic Adenocarcinoma368.0CCNE1, IL6, GRB2, JAK2, VEGFC, KIT
46Antioxidant Action of Vitamin-C367.7NFKB1, PLCG2, CSF3, EGFR, JUN, KIT
47Molecular Mechanisms of Cancer367.6CCL5, CCR7, TP53, AKT1, VEGFC, PIK3CG
48p38 Signaling367.4IL1R1, CSF3, STAT1, EGFR, PLCG2, GRB2
49JAK-STAT Pathway366.9CCL5, AKT1, EPO, IL1R1, IL2RA, IL4
50Hematopoietic cell lineage20INFDNTT, CSF3, KIT, , FCER2, IL1R1

Compounds for genes affiliated with Mediastinitis

about this section
Sources:
32Novoseek , 42Tocris Bioscience, 9DrugBank, 18HMDB, 34PharmGKB
See all sources

Compounds related to mediastinitis according to GeneDecks:

(show top 50)    (show all 377)
idCompoundScoreTop Affiliating Genes
1glucose32 10.3KIT, VEGFC, CGB, IL4I1, IFNA2, PTH
2dmso32 10.1VIM, SDHB, CGA, F3, ALPP, CYBB
3polyethylene glycol32 9.7SELE, CHKB, MPO, IFNA2, ALPP, TSHR
412-o-tetradecanoylphorbol 13-acetate32 8.9MYC, BCL6, JAK2, GRB2, FCER2, IL1R1
5cysteine32 8.9REL, PCNA, MYB, CLU, SDHB, CHKB
6calcitriol32 42 9 18 9 12.8MYC, CLU, PAX5, JUN, MLL, FCER2
7pge232 8.8SELE, CGA, FCER2, IL13, IL1R1, CCL5
8epinephrine32 9 18 9 11.7SELE, SDHB, CHKB, CGA, JAK2, CD79A
9glutamate32 8.7PCNA, VIM, CLU, SDHB, JAK2, CD79A
10aspartate32 8.7PCNA, VIM, SDHB, CHKB, CGA, CEACAM3
11h2o232 8.7PIK3CG, MYB, BLNK, CLU, BCR, SDHB
12thyroxine32 18 9.7PCNA, CHKB, CGA, CGB, CEACAM3, CD79A
13ribonucleic acid32 8.5KIT, VEGFC, MYC, CLU, CGA, IL1R1
14estradiol32 9 18 9 11.4PCNA, VIM, VEGFC, MYB, CHKB, CGA
15arginine32 8.1MYB, SDHB, CHKB, CGA, CD79A, MLH1
16fibrinogen32 8.1SELE, CLU, CHKB, CEACAM3, CD79A, IL1R1
17butyrate32 8.1PCNA, VIM, MYC, MYB, CLU, MPO
18phosphoinositide32 8.0PIK3CG, KIT, VIM, BLNK, BCR, JUN
19cyclosporin a32 42 8.8PIK3CG, REL, MYC, MYB, SDHB, CHKB
20ly29400232 7.8PIK3CG, SELE, BCR, JUN, GRB2, IL13
21n acetylcysteine32 7.8PCNA, SELE, CLU, JAK2, CD79A, GRB2
22imatinib32 34 9 9 10.6PIK3CG, KIT, MYC, MYB, BCL6, BCR
23cholesterol32 9 18 9 10.6SELE, CLU, PAX5, BCR, SDHB, CHKB
24nitric oxide32 9 18 9 10.6REL, KIT, SELE, VEGFC, CHKB, S100A1
25etoposide32 42 9 9 10.6PIK3CG, PCNA, SELE, MYC, CLU, CGA
26estrogen32 7.6PCNA, VEGFC, CLU, CHKB, S100A1, CGA
27aspirin32 34 18 9.6PCNA, SELE, CHKB, CGA, JAK2, CD79A
28phosphatidylinositol32 7.5PIK3CG, KIT, VEGFC, MYC, BCR, JAK2
29prednisolone32 9 9 9.5MYC, CHKB, MPO, CD79A, MLL, IL13
30vitamin d32 7.4VIM, CLU, PAX5, CHKB, CGA, JUN
31lipid32 7.3PIK3CG, SELE, VIM, VEGFC, MYB, CLU
32creatinine32 7.2PCNA, SELE, SDHB, CGA, CGB, CEACAM3
33cytarabine32 34 9 9 9.9KIT, PCNA, VIM, MYC, BCR, MPO
34histamine32 18 7.8KIT, PCNA, SELE, VIM, CGA, MPO
35alanine32 6.6PCNA, SELE, MYC, MYB, CHKB, CGA
365fluorouracil32 6.3PIK3CG, KIT, PCNA, SELE, CEACAM3, MPO
37cisplatin32 34 9 9 9.1PCNA, MYC, CLU, CGA, CGB, MPO
38methotrexate32 34 42 9 9 10.1KIT, PCNA, SELE, VIM, CHKB, CGA
39indomethacin32 9 9 8.0PCNA, VIM, MYC, CGA, MPO, JAK2
40doxorubicin32 34 9 9 8.8PIK3CG, KIT, SELE, VIM, MYB, CLU
41tamoxifen32 34 9 9 8.7PCNA, SELE, VIM, MYC, CLU, CHKB
42actinomycin d32 5.7PIK3CG, KIT, SELE, VIM, MYC, MYB
43dexamethasone32 42 34 9 9 9.7REL, PCNA, VIM, VEGFC, MYC, MYB
44paclitaxel32 34 9 9 8.6PIK3CG, KIT, PCNA, VIM, MYC, CLU
45genistein32 9 18 9 8.2PIK3CG, PCNA, SELE, VIM, MYC, BCR
46retinoic acid32 42 18 6.8PIK3CG, REL, KIT, VEGFC, MYC, MYB
47testosterone32 9 18 9 7.6KIT, PCNA, SELE, VIM, VEGFC, CLU
48cycloheximide32 4.3PIK3CG, KIT, SELE, VIM, MYC, MYB
49paraffin32 INFKIT, PCNA, VIM, VEGFC, MYC, CLU
50calcium32 9 18 9 INFREL, KIT, VEGFC, MYB, BLNK, PAX5

GO Terms for genes affiliated with Mediastinitis

about this section
Sources:
12Gene Ontology
See all sources

Cellular components related to mediastinitis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.2LYN, EGFR, PTPRC, MAL, CD79A, JAK2
2cytosolGO:0058297.8TSC1, NFKB1, PLCG2, PTPN11, TNFAIP3, SYK
3extracellular regionGO:0055767.3F5, CALCA, PTH, PTGDS, SST, CRH
4extracellular spaceGO:0056155.9KIT, PTH, PTGDS, SST, CRH, CRP
5cytoplasmGO:0057375.6TSC1, EGFR, NFKB1, PPP6R2, PTPN11, TNFRSF8
6plasma membraneGO:005886INFEGFR, PLCG2, PLAUR, PLAU, CYSLTR1, PTPRC
7external side of plasma membraneGO:009897INFIL4, CCR7, PTPRC, ADA, IL13, FCER2

Biological processes related to mediastinitis according to GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1regulation of interferon-gamma-mediated signaling pathwayGO:06033410.5JAK2, PTPN11, STAT1, SOCS1
2induction of apoptosis by hormonesGO:00862810.5CRH, SST, PTH
3JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.4LYN, SOCS1, STAT1, JAK2
4regulation of inflammatory responseGO:05072710.4LYN, CALCA, JAK2, BCL6, SELE
5leukocyte cell-cell adhesionGO:00715910.3SYK, PTPRC, CALCA, CCL5, SELE
6B cell receptor signaling pathwayGO:05085310.3LYN, SYK, PLCG2, PTPRC, CD79A
7positive regulation of B cell proliferationGO:03089010.2ADA, PTPRC, IL4, IL13, BCL6
8regulation of cell adhesion mediated by integrinGO:03362810.2LYN, PLAU, PTPN11, PIK3CG
9B cell differentiationGO:03018310.1TSHR, PLCG2, PTPRC, AICDA, IL4, CD79A
10humoral immune responseGO:00695910.1POU2F2, POU2AF1, IL6, PAX5, BLNK
11protein import into nucleus, translocationGO:00006010.1ABRA, TP53, AKT1, BCL6
12regulation of type I interferon-mediated signaling pathwayGO:06033810.0SOCS1, STAT1, PTPN11, IFNA2
13positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.0EPO, IL4, JAK2, KIT
14agingGO:0075689.7EPO, ADA, CALCA, F3, CCL5, GRB2
15response to lipopolysaccharideGO:0324969.7EPO, NKX2-1, SOCS1, PLCG2, F3, CCR7
16release of cytochrome c from mitochondriaGO:0018369.6TP53, JUN, CLU, MYC
17positive regulation of smooth muscle cell proliferationGO:0486619.6IL13, IL6, CCL5, STAT1, JUN
18cell-cell signalingGO:0072679.6PTH, SST, TSHR, PGR, ADORA1, CALCA
19positive regulation of cell migrationGO:0303359.4CGA, JAK2, CCL5, F3, EGFR, LYN
20innate immune responseGO:0450879.3LYN, SYK, NFKB1, CYBB, TNFAIP3, IFNA2
21negative regulation of transcription from RNA polymerase II promoterGO:0001229.3NKX2-1, STAT1, NFKB1, SPI1, PTH, TP53
22negative regulation of gene expressionGO:0106299.3PGR, PLAUR, ESR1, IFNA2, BCL11A
23cell surface receptor signaling pathwayGO:0071669.3EGFR, SST, PTPRC, IFNA2, IL2RA, IL1R1
24cytokine-mediated signaling pathwayGO:0192219.2CSF3, SOCS1, STAT1, PTPN11, IFNA2, IL6
25negative regulation of cell proliferationGO:0082859.1ADORA1, LYN, NME1, TSC1, SST, TNFRSF8
26response to drugGO:0424939.0SST, ABCB1, SOCS1, NME1, LYN, CCL5
27platelet activationGO:0301688.9LYN, SYK, PLCG2, AKT1, F5, IL6
28positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.7ABRA, ESR1, AKT1, IL6, IL4, JAK2
29positive regulation of nitric oxide biosynthetic processGO:0454298.4EGFR, ESR1, AKT1, JAK2
30blood coagulationGO:0075968.3TP53, PTPN11, PLAU, PLAUR, PLCG2, SYK
31positive regulation of cell proliferationGO:0082848.3TSHR, CSF3, LYN, EPO, EGFR, IL6
32positive regulation of transcription, DNA-dependentGO:0458938.2SPI1, NFKB1, STAT1, POU2F2, NKX2-1, EPO
33inflammatory responseGO:0069547.9PIK3CG, ADORA1, NFKB1, CRP, CRH, CYBB
34negative regulation of apoptotic processGO:0430667.8PLAUR, EGFR, ADORA1, EPO, TP53, AKT1
35signal transductionGO:0071657.3CRH, PLAU, PLAUR, EGFR, STAT6, PGR
36positive regulation of transcription from RNA polymerase II promoterGO:0459447.3ESR1, TP53, PTH, SPI1, NFKB1, ABRA
37T cell costimulationGO:031295INFCD274, , GRB2, AKT1, PTPN11, LYN

Molecular functions related to mediastinitis according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.8EPO, CRH, SST, PTH, CALCA, CGB
2receptor signaling protein tyrosine kinase activityGO:0047169.6LYN, SYK, EGFR, KIT
3protease bindingGO:0020209.3TNFAIP3, TP53, F3, IL1R1, KIT
4nitric-oxide synthase regulator activityGO:0302358.7AKT1, ESR1, EGFR
5enzyme bindingGO:0198997.8LYN, PGR, CSF3, STAT1, EGFR, PLAUR
6sequence-specific DNA binding transcription factor activityGO:0037007.7SPI1, NFKB1, STAT6, STAT1, POU2F2, NKX2-1
7identical protein bindingGO:0428027.7NME1, STAT6, DNM1, EGFR, TP53, ESR1
8protein bindingGO:005515INFEPO, PLCG2, PLAUR, PLAU, CRP, CRH
9transmembrane signaling receptor activityGO:004888INFSELE, CD79A, , IL1R1, TNFRSF8, EGFR

Sources for Mediastinitis

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
Browse MalaCards: 1-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z