MCID: MDS022
MIFTS: 49

Mediastinitis malady

Summaries for Mediastinitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

MalaCards: Mediastinitis is related to lymphoma, diffuse large cell and acute leukemia. An important gene associated with Mediastinitis is TNFAIP2 (tumor necrosis factor, alpha-induced protein 2), and among its related pathways are Rho Family GTPases and Development PDGF signaling via STATs and NF-kB. The compounds retinoic acid and tyrosine have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Mediastinitis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt, 27ICD9CM, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

mediastinitis 8 10 61


External Ids:

Disease Ontology8 DOID:819
NCIt40 C26827
SNOMED-CT57 47597000
ICD9CM27 519.2
MeSH35 D008480

Related Diseases for Mediastinitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mediastinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 496)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma, diffuse large cell30.4MLLT10, MYC, PAX5, BCL6
2acute leukemia30.4CSF3, PAX5, JAK2, MLLT10
3graves' disease30.3STAT6, IL13
4adenocarcinoma30.1TP53, MYC, AFP, JAK2
5hypercalcemia30.1ALPPL2
6germ cell cancer30.0AFP, ALPPL2
7diffuse large b-cell lymphoma29.8MUM1
8anaplastic large cell lymphoma29.8PAX5, BCL6
9arthritis29.8ALPPL2, IL13, STAT6
10follicular lymphoma29.8PAX5, MYC, REL, BCL6
11bronchiolitis29.8IL13
12b-cell lymphomas29.6MYC, TP53, STAT6, BCL6, PAX5, IL4I1
13burkitt's lymphoma29.6JAK2, TP53, BCL6, PAX5, REL, MYC
14central nervous system lymphoma29.6BCL6
15atherosclerosis29.6STAT6
16astrocytoma29.6TP53, PAX5, IL13
17lymphoma, malt, somatic29.6BCL6
18central nervous system lymphoma, primary29.6BCL6, PAX5
19asthma29.6STAT6, IL13
20fibrosing mediastinitis10.8
21teratoma10.7
22adenoma10.7
23bronchogenic cyst10.5
24mediastinal lipomatosis10.5
25superior vena cava syndrome10.5
26germ cell tumors10.4
27tuberculosis10.4
28bronchogenic carcinoma10.4
29n syndrome10.4
30lymphoblastic lymphoma10.4
31klinefelter's syndrome10.4
32mediastinal gray zone lymphoma10.4
33ganglioneuroma10.4
34thymoma10.4
35cystic lymphangioma10.3
36primary mediastinal large b-cell lymphoma10.3
37parathyroid carcinoma10.3
38synovial sarcoma10.3
39nonseminomatous germ cell tumor10.3
40malignant germ cell tumor10.3
41paraganglioma10.3
42hemangioendothelioma10.3
43small cell carcinoma10.3
44lipoblastoma10.3
45necrotizing fasciitis10.2
46germinoma10.2
47thymic hyperplasia10.2
48dysphagia10.2
49growing teratoma syndrome10.2
50cardiac tamponade10.2

Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to mediastinitis

Clinical Features for Mediastinitis

Drugs & Therapeutics for Mediastinitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Mediastinitis

Drug clinical trials:

Search ClinicalTrials for Mediastinitis

Search NIH Clinical Center for Mediastinitis

Search CenterWatch for Mediastinitis

Genetic Tests for Mediastinitis

Anatomical Context for Mediastinitis

Animal Models for Mediastinitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Mediastinitis

Sources:
51PubMed
See all sources

Articles related to Mediastinitis:

(show top 50)    (show all 575)
idTitleAuthorsYear
1
Descending necrotizing Mediastinitis caused by Kocuria rosea: a case report. (24112281)
2013
2
Ozone therapy as an adjunct to vancomycin enhances bacterial elimination in methicillin resistant Staphylococcus aureus mediastinitis. (23809152)
2013
3
Fulminant mediastinitis due to extended-spectrum beta-lactamase-producing Klebsiella pneumoniae: atypical presentation and spreading following cardiac surgery. (23416348)
2013
4
Proteus Mediastinitis Causing Fatal Pseudoaneurysm following Aortic Valve Replacement. (24369472)
2013
5
Descending necrotizing mediastinitis associated with spinal cord abscess. (23430432)
2013
6
Descending necrotizing mediastinitis and thoracic cellulitis due to varicella. (22371953)
2012
7
Management of sterno-mediastinitis. (23439488)
2012
8
Fatal post-operative Trichoderma longibrachiatum mediastinitis and peritonitis in a paediatric patient with complex congenital cardiac disease on peritoneal dialysis. (21799200)
2011
9
Bilateral breast enlargement: an unusual presentation of superior vena cava obstruction in a hemodialysis patient with fibrosing mediastinitis. (19949792)
2011
10
Successfully treated descending necrotizing mediastinitis through thoracotomy using a pedicled muscular serratus anterior flap. (21791516)
2011
11
A case of mediastinitis after radiofrequency ablation for Barrett's esophagus. (22000796)
2011
12
Update on necrotizing mediastinitis: causes, approaches to management, and outcomes. (21369879)
2011
13
Poststernotomy sternal osteomyelitis and mediastinitis by Trichosporon asahii: a rare occurrence with a grave prognosis. (19761488)
2010
14
Octreotide, a somatostatin analogue, in the treatment of chylothorax associated with idiopathic fibrosing mediastinitis. (20814178)
2010
15
Descending necrotising mediastinitis: two case reports and review of the literature. (20956183)
2010
16
The role of omental transposition for the management of postoperative mediastinitis: a case series. (19236690)
2009
17
Mediastinitis in infants from deep neck space infections. (19467419)
2009
18
Lecompte's closed drainage method combined with omentoplasty: an elective treatment for acute mediastinitis after prosthetic replacement of the ascending aorta?--two successfully treated cases. (19341214)
2009
19
Does bilateral pedicle internal thoracic artery harvest increase the risk of mediastinitis? (19259352)
2009
20
Acinetobacter baumannii mediastinitis after cardiopulmonary bypass: case report and literature review. (18426353)
2008
21
Post-operative mediastinitis, pleuritis and pericarditis due to Mycoplasma hominis and Ureaplasma urealyticum with a fatal outcome. (18436601)
2008
22
Vacuum-assisted sternal closure after a 'depression induced ischemic test' in severe mediastinitis. (18475132)
2008
23
Fibrosing mediastinitis mimicking malignancy at CT: negative FDG uptake in integrated FDG PET/CT imaging. (16944162)
2007
24
Omental flap for recurrent deep sternal wound infection and mediastinitis after cardiac surgery. (17721846)
2007
25
Gemella morbillorum mediastinitis and osteomyelitis following transesophageal endoscopic ultrasound-guided fine-needle aspiration of a posterior mediastinal lymph node. (17440855)
2007
26
Cultures of sternal wound and mediastinum taken at the end of heart surgery do not predict postsurgical mediastinitis. (16930920)
2006
27
Unilateral pulmonary edema due to pulmonary venous obstruction from fibrosing mediastinitis. (16520136)
2006
28
Sclerosing mediastinitis in the differential diagnosis of mediastinal tumors. (17273573)
2006
29
High-pressure irrigation and gentian-violet application for mediastinitis following replacement of ascending aorta and aortic valve. (17143718)
2006
30
Mediastinitis and pseudoaneurysm of brachiocephalic artery long after the resection of invasive thymoma and postoperative irradiation. (16153964)
2005
31
Is video-assisted thoracoscopic surgery an optimal approach for descending necrotizing mediastinitis? (15680891)
2005
32
Pseudomonas mediastinitis at the aortic cannulation site. (15061644)
2004
33
Aspergillus mediastinitis following orthotopic heart transplantation: case report and review of the literature. (15569230)
2004
34
A report of four cases of acute mediastinitis occurring following tracheoesophageal puncture in laryngectomees. (16027490)
2004
35
Successful treatment of methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis in a heart transplant recipient. (15145023)
2004
36
Management with closed irrigation for post-sternotomy mediastinitis: experience with the use of electrolyzed strong acid aqueous solution. (14621012)
2003
37
Thoracoscopic drainage with wound edge protector for descending necrotizing mediastinitis. (17669988)
2003
38
Right ventricular rupture during use of high-pressure suction drainage in the management of poststernotomy mediastinitis. (12963251)
2003
39
Mediastinitis complicating a percutaneous endoscopic gastrostomy: a case report. (12791167)
2003
40
Mediastinitis presenting as pyrexia of unknown origin. (12723660)
2003
41
Poststernotomy mediastinitis due to methicillin-resistant Staphylococcus aureus endemic in a hospital. (12942400)
2003
42
A rare complication of tooth abscess--Ludwig's angina and mediastinitis. (11450295)
2001
43
Acute mediastinitis. (16389322)
2000
44
A case of fibrosing mediastinitis with obstruction of superior vena cava and downhill esophageal varices: a rare cause of upper gastrointestinal hemorrhage. (10192621)
1999
45
Fibrosing mediastinitis: CT and MR findings. (9867275)
1998
46
Fibrosing mediastinitis causing nonvisualization of one lung on pulmonary scintigraphy. (8344031)
1993
47
Cervical manifestations of fibrosing mediastinitis: a diagnostic and therapeutic dilemma. (8253566)
1993
48
Fibrosing mediastinitis. (3226451)
1988
49
CT of fibrosing mediastinitis: findings and their utility. (6603112)
1983
50
Pulmonary scintigraphy in fibrosing mediastinitis due to histoplasmosis. (7205381)
1981

Genetic Variations for Mediastinitis

Expression for genes affiliated with Mediastinitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Pathways for genes affiliated with Mediastinitis

Sources:
52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 53R&D Systems, 54Reactome
See all sources

Pathways related to Mediastinitis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CSF3, JAK2, STAT6, NFKB1, MYC, IL13
2
Development PDGF signaling via STATs and NF-kB
Hide members
10.5REL, MYC, NFKB1, STAT6, JAK2
310.5TP53, BCL6, PAX5, REL, MYC, NFKB1
4
Hide members
10.5CSF3, JAK2, STAT6, NFKB1, IL13, TP53
5
Hide members
10.5STAT6, NFKB1, REL, IL13, BCL6
6
Hide members
10.5CSF3, JAK2, NFKB1, MYC, IL13, TP53
710.5IL13, MYC, STAT6, JAK2, CSF3
8
Hide members
10.5JAK2, STAT6, NFKB1, REL
9
Hide members
10.5JAK2, STAT6, NFKB1, IL13
10
Hide members
10.5MYC, NFKB1, STAT6, JAK2
1110.5JAK2, STAT6, NFKB1, MYC
12
Hide members
10.5JAK2, STAT6, NFKB1, MYC
13
Hide members
10.5REL, MYC, NFKB1, JAK2
14
Development Prolactin receptor signaling
Hide members
10.5JAK2, NFKB1, MYC, REL
15
Immune response IL-2 activation and signaling pathway
Hide members
10.5JAK2, NFKB1, MYC, REL
1610.5TP53, IL13, NFKB1, AFP
17
Hide members
10.5TP53, MYC, NFKB1, STAT6
1810.5NFKB1, MYC, REL, TP53
19
Hide members
10.5TP53, REL, MYC, NFKB1
2010.5CSF3, JAK2, NFKB1, MYC, TP53
21
Cytokine production by Th17 cells in CF (Mouse model)
10.5CSF3, JAK2, NFKB1, REL
2210.5NFKB1, STAT6, JAK2
23
Hide members
10.5JAK2, STAT6, NFKB1
2410.5JAK2, STAT6, NFKB1
25
Mucin expression in CF via IL-6, IL-17 signaling pathways
Hide members
10.5REL, NFKB1, JAK2
26
Hide members
10.5REL, NFKB1, JAK2
27
Immune response Bacterial infections in normal airways
10.5JAK2, NFKB1, REL
2810.5REL, MYC, NFKB1
29
Development A3 receptor signaling
Hide members
10.5NFKB1, MYC, REL
30
Hide members
10.5NFKB1, MYC, BCL6, TP53
31
Transcription P53 signaling pathway
Hide members
10.5TP53, REL, NFKB1
32
Hide members
10.5TP53, REL, NFKB1
33
Development EPO-induced Jak-STAT pathway
Hide members
10.5JAK2, NFKB1, MYC
34
Hide members
10.5TP53, NFKB1, JAK2
35
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.5TP53, NFKB1, JAK2
36
Hide members
10.5IL13, STAT6
37
Hide members
10.5NFKB1, MYC, TP53
3810.5TP53, MYC, NFKB1
39
Hide members
10.5TP53, MYC, NFKB1
4010.5NFKB1, MYC, BCL6
4110.5NFKB1, REL

Compounds for genes affiliated with Mediastinitis

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Mediastinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2412.0TP53, CSF3, TNFAIP2, JAK2, STAT6, AFP
2tyrosine4511.0REL, MYC, AFP, STAT6, JAK2, CSF3
3dexamethasone45 50 29 1114.0STAT6, AFP, MYC, REL, IL13
4serine4511.0IL4I1, STAT6, AFP, IL13, JAK2
5actinomycin d4511.0TP53, AFP, STAT6, JAK2, MYC, IL13
6hydroxyurea45 50 1113.0MYC, CSF3, JAK2, TP53, IL13
7oligonucleotide4511.0REL, PAX5, JAK2, STAT6, AFP, MYC
8vincristine45 50 1113.0CSF3, AFP, MYC, BCL6, TP53
9cyclophosphamide45 50 1113.0AFP, TP53, IL13, BCL6, CSF3
10doxorubicin45 50 1113.0TP53, BCL6, MYC, CSF3, AFP, IL13
11cytidine45 11 2412.9MYC, PAX5, BCL6, STAT6
1210-hydroxycamptothecin4510.9MYC, TP53, AFP
13paraffin4510.9PAX5, AFP, BCL6, ALPPL2, MYC, TP53
14thymidine45 2411.9TP53, MYC, CSF3, IL13, AFP, JAK2
15melphalan45 1111.9IL4I1, TP53, CSF3, MYC
16rituximab45 50 1112.9IL13, PAX5, CSF3, BCL6
17bleomycin45 1111.9IL13, AFP, TP53, CSF3
18etoposide45 50 60 1113.9AFP, TP53, MYC, CSF3, NFKB1
19amifostine45 1111.9ALPPL2, CSF3, TP53
20mg 13245 6011.9MYC, JAK2, TP53, STAT6
21adriamycin4510.9AFP, MYC, TP53, CSF3
225-aza-2deoxycytidine4510.9MYC, TP53, JAK2, MAL
23cyclosporin a45 29 6012.9CSF3, MYC, JAK2, REL, IL13
24threonine4510.9STAT6, REL, AFP, MYC, IL13, JAK2
25butyrate4510.9ALPPL2, JAK2
26imatinib45 50 1112.9MYC, BCL6, CSF3, JAK2
27vegf4510.9AFP, MYC, IL13, TP53, CSF3, JAK2
28tachyplesin i4510.9MYC, AFP
29estrogen4510.9BCL6
30tanshinone iia4510.8MYC, TP53
31anti-fungal4510.8CSF3, AFP, REL
32cisplatin45 50 60 1113.8JAK2, TP53, AFP, CSF3, MYC
33chloramphenicol45 2 1112.8AFP, MYC, IL13, REL
34leucine4510.8MYC, MLLT10, JAK2, IL4I1, ALPPL2
35vinblastine45 50 1112.8TP53, AFP
36acnu4510.8TP53, CSF3
37irinotecan45 50 1112.8TP53, AFP, CSF3
38acetaminophen45 2 50 11 2414.8IL13, MYC, AFP
39n acetylcysteine4510.8STAT6, MYC, JAK2, TP53
40carboplatin45 50 1112.7TP53, CSF3, AFP
414-hydroperoxycyclophosphamide4510.7CSF3, MYC
42sb 20358045 6011.7JAK2, TP53, IL13, STAT6
43aclarubicin4510.7CSF3, MYC
44thalidomide45 50 60 1113.7AFP, NFKB1, IL13
45h2o24510.6IL4I1, JAK2, AFP, IL13, TP53
46vesnarinone4510.6MYC, CSF3
47paclitaxel45 50 1112.5CSF3, AFP, TP53, MYC
48mitomycin c4510.5CSF3, AFP, TP53
49gemcitabine45 50 1112.4CSF3, TP53, MYC
50gp 1304510.2JAK2, IL13, CSF3

GO Terms for genes affiliated with Mediastinitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.5TP53, BCL6

Biological processes related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:00012210.5TP53, FOXN1, STAT6, NFKB1, MYC, PAX5
2positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5TP53, JAK2, CSF3
3positive regulation of transcription from RNA polymerase II promoterGO:04594410.4CSF3, STAT6, MLLT10, NFKB1, MYC, PAX5
4negative regulation of type 2 immune responseGO:00282910.2BCL6, STAT6

Molecular functions related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:00813410.5TP53, MYC, NFKB1, FOXN1
2sequence-specific DNA binding transcription factor activityGO:00370010.2TP53, STAT6, MLLT10, NFKB1, MYC, REL

Products for genes affiliated with Mediastinitis

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  • Lysates
  • Antibodies

Sources for Mediastinitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet