MCID: MDS022
MIFTS: 56

Mediastinitis malady

Summaries for Mediastinitis

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

MalaCards: Mediastinitis is related to seminoma and sarcoma. An important gene associated with Mediastinitis is TNFAIP2 (tumor necrosis factor, alpha-induced protein 2), and among its related pathways are Rho Family GTPases and Development PDGF signaling via STATs and NF-kB. The compounds retinoic acid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include b cells, lymph node and lung, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Mediastinitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 27ICD9CM, 34MeSH, 56SNOMED-CT
See all sources

Aliases & Descriptions:

mediastinitis 8 10 60


External Ids:

Disease Ontology8 DOID:819
NCIt39 C26827
SNOMED-CT56 47597000
ICD9CM27 519.2
MeSH34 D008480

Related Diseases for Mediastinitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mediastinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 489)
idRelated DiseaseScoreTop Affiliating Genes
1seminoma30.7ALPPL2, AFP
2sarcoma30.7TP53, JAK2
3esophagitis30.7IL13
4leukemia30.5CSF3, JAK2, MLLT10, NFKB1, MYC, REL
5lung cancer30.5CSF3, MYC, TP53
6hodgkin's lymphoma30.4CSF3, JAK2, STAT6, REL, IL13, PAX5
7diffuse large b-cell lymphoma30.4MUM1
8acute leukemia30.3CSF3, JAK2, MLLT10, PAX5
9pancreatitis30.3ALPPL2
10graves' disease30.2IL13, STAT6
11myeloid leukemia30.2MYC, MLLT10, JAK2, CSF3
12lung small cell carcinoma30.2CSF3, MYC, PAX5, TP53
13plasmacytoma30.2MYC, PAX5, BCL6
14endodermal sinus tumor30.2AFP, ALPPL2
15hyperparathyroidism30.2ALPPL2
16choriocarcinoma30.1ALPPL2, AFP, JAK2
17adenocarcinoma30.1JAK2, AFP, MYC, TP53
18neuroblastoma30.1TP53, MYC
19hypercalcemia30.1ALPPL2
20burkitt's lymphoma29.9CSF3, JAK2, STAT6, MYC, REL, PAX5
21hepatitis29.9AFP
22anaplastic large cell lymphoma29.8BCL6, PAX5
23arthritis29.8STAT6, IL13, ALPPL2
24down syndrome29.8JAK2, AFP
25bronchiolitis29.8IL13
26myeloma29.6CSF3, JAK2, MYC, PAX5, BCL6, ALPPL2
27breast cancer29.6CSF3, JAK2, STAT6, NFKB1, MYC, REL
28rheumatoid arthritis29.6JAK2, STAT6, CD274, IL13
29multiple myeloma29.6TP53, CSF3
30non-hodgkin lymphoma29.6CSF3, JAK2, MYC, PAX5, BCL6
31colon cancer29.6JAK2, STAT6, MYC, ALPPL2, TP53
32central nervous system lymphoma29.6BCL6
33glioblastoma multiforme29.6JAK2, STAT6, MYC, IL13, TP53
34atherosclerosis29.6STAT6
35astrocytoma29.6TP53, PAX5, IL13
36dilated cardiomyopathy29.6STAT6
37hyperthyroidism29.6ALPPL2
38malt lymphoma29.6BCL6
39esophageal cancer29.6TP53
40adenoma10.6
41parathyroid adenoma10.6
42mediastinal cancer10.5
43mediastinal lipomatosis10.5
44lipomatosis10.5
45cervicitis10.4
46goiter10.4
47lymphangioma10.4
48lymphadenitis10.4
49mature teratoma10.4
50liposarcoma10.4

Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to mediastinitis

Clinical Features for Mediastinitis

About this section

Drugs & Therapeutics for Mediastinitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Mediastinitis

Drug clinical trials:

Search ClinicalTrials for Mediastinitis

Search NIH Clinical Center for Mediastinitis

Search CenterWatch for Mediastinitis

Genetic Tests for Mediastinitis

About this section

Anatomical Context for Mediastinitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Mediastinitis:

32
B cells, Lymph node, Lung, Heart, Thyroid, Myeloid, Bone, T cells, Liver, Skin, Breast, Colon, Tonsil, Trachea, Thymus, Bone marrow, Spinal cord, Ovary, Prostate, Pancreas, Pituitary, Brain, Kidney, Monocytes, Spleen, Testes

Animal Models for Mediastinitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Mediastinitis:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.8TP53, CSF3, FOXN1, JAK2, STAT6, NFKB1
2MP:000538710.8CSF3, FOXN1, JAK2, STAT6, NFKB1, MYC
3MP:000538410.8FOXN1, JAK2, STAT6, NFKB1, MYC, CD274
4MP:001077110.8FOXN1, STAT6, MYC, REL, IL13, TP53
5MP:001076810.8NFKB1, AFP, STAT6, JAK2, FOXN1, MYC
6MP:000537610.7FOXN1, JAK2, STAT6, AFP, NFKB1, MYC
7MP:000539010.7FOXN1, JAK2, MYC, PAX5
8MP:000537010.7FOXN1, STAT6, NFKB1, MYC, REL, BCL6
9MP:000538910.6FOXN1, STAT6, AFP, MYC, IL13, TP53
10MP:000537810.6FOXN1, JAK2, STAT6, NFKB1, MYC, REL
11MP:000537710.5IL13, FOXN1
12MP:000200610.4FOXN1, STAT6, AFP
13MP:000537910.2TP53, MYC, AFP, JAK2, FOXN1

Publications for Mediastinitis

About this section
Sources:
50PubMed
See all sources

Articles related to Mediastinitis:

(show top 50)    (show all 1742)
idTitleAuthorsYear
1
Primary closure using Redon drains for the treatment of post-sternotomy mediastinitis. (24071369)
2014
2
Mediastinal hemangioma: Masquerading as pleural effusion. (24347874)
2013
3
Video-assisted thoracoscopic surgery for ectopic middle mediastinal thymoma in a patient with myasthenia gravis. (23438567)
2013
4
Functional mediastinal pheochromocytoma. (23423879)
2013
5
Group A Streptococcus causing descending necrotizing mediastinitis: report of a case and literature review. (22316143)
2012
6
Spontaneous rupture of benign mediastinal teratoma: A report of two cases. (22988355)
2012
7
Mediastinitis after the use of the LMA-Supreme. (21970153)
2011
8
Simultaneous tumors: acute myeloid leukemia infiltrating mediastinal ganglioneuroblastoma. (20973101)
2011
9
Chronic esophageal foreign bodies and secondary mediastinitis in children. (21922979)
2011
10
Mediastinal gray zone lymphoma. (21454881)
2011
11
Mitral valve replacement via right thoracotomy approach for prevention of mediastinitis in a female patient with long-term uncontrolled diabetes mellitus: a case report. (20478046)
2010
12
Prognostic factors in patients with primary mediastinal germ cell tumors, a surgical multicenter retrospective study. (20709694)
2010
13
Sarcoidosis-associated fibrosing mediastinitis with resultant pulmonary hypertension: a case report and review of the literature. (19797887)
2010
14
Mediastinal epithelioid hemangioendothelioma metastatic to lymph nodes and pleural fluid: report of a case. (19688765)
2010
15
Hepatic pulmonary fusion in an infant with a right-sided congenital diaphragmatic hernia and contralateral mediastinal shift. (20105618)
2010
16
Relapse with malignant transformation after chemotherapy for primary mediastinal seminoma: case report. (19395465)
2009
17
Acute mediastinitis secondary to venous perforation by a peripherally inserted central venous catheter. (19201204)
2009
18
Radio-guided thoracoscopic surgery with (99m)Tc-methoxy-isobutylisonitrile for treating an ectopic mediastinal parathyroid adenoma in an adolescent girl. (20013101)
2009
19
Aspergillus mediastinitis diagnosed by EUS-guided FNA. (17981273)
2008
20
Metastatic malignant teratoma arising from mediastinal nonseminomatous germ cell tumor: a case report. (18472634)
2008
21
Thoracoscopic removal of a maternal mediastinal ectopic parathyroid adenoma causing neonatal hypocalcemia: a case report. (18989251)
2008
22
Sigmoid colon cancer with mediastinal lymph node metastases. (18050829)
2007
23
Cardiac sarcoidosis underlies idiopathic dilated cardiomyopathy: importance of mediastinal lymphadenopathy in differential diagnosis. (18037750)
2007
24
A case of CD56 positive T-cell lymphoma originating from mediastinal lymph nodes]. (17233392)
2006
25
Complication of mediastinal mass: acquired tracheoesophageal fistula associated with T-cell lymphoblastic lymphoma. (16703600)
2006
26
Thoracoscopic resection of a mediastinal intrathymic parathyroid adenoma. (16447483)
2005
27
Descending necrotizing mediastinitis: trends in a developing country. (15929325)
2005
28
Sealing of the mediastinum with a local hemostyptic agent reduces chest tube duration after complete mediastinal lymph node dissection for stage I and II non-small cell lung carcinoma. (14992920)
2004
29
Mediastinal recurrence of alveolar echinococcosis after liver transplantation. (12514779)
2003
30
Thoracoscopic excision of mediastinal bronchogenic cyst: a case report and review of literature. (12866638)
2003
31
Monocytic leukemia with CALM/AF10 rearrangement showing mediastinal emphysema. (12555219)
2003
32
Elevated preoperative fasting serum glucose levels increase the risk of postoperative mediastinitis in patients undergoing open heart surgery. (14587944)
2003
33
Descending necrotizing mediastinitis. (12518725)
2002
34
Posterior mediastinal neurofibrosarcoma in a patient with von Recklinghausen's disease. (10413818)
1999
35
CNS involvement in primary mediastinal large B-cell lymphoma. (10561312)
1999
36
Fibrosing mediastinitis associated with Riedel's thyroiditis--computed tomographic findings: case report. (9879270)
1998
37
Magnetic resonance imaging and 67Ga scan versus computed tomography in the staging and in the monitoring of mediastinal malignant lymphoma: a prospective pilot study. (9220410)
1996
38
A patient with combined mediastinal, mesenteric and retroperitoneal fibrosis. (8052346)
1994
39
Hemodynamic compromise secondary to a mediastinal bronchogenic cyst. (7774349)
1994
40
MEN type 1 associated with mediastinal carcinoid producing parathyroid hormone, calcitonin and chorionic gonadotropin. (7905624)
1993
41
Anterior mediastinal fibrosis with superior vena caval obstruction complicating the synovitis-acne-pustulosis-hyperostosis-osteomyelitis syndrome. (8495263)
1993
42
Chronic fibrosing mediastinitis and superior vena caval obstruction from blastomycosis. (1417237)
1992
43
Fatal necrotizing mediastinitis secondary to acute suppurative parotitis. (2030539)
1991
44
Superior vena cava syndrome due to chronic granulomatous mediastinitis. (2291317)
1990
45
Horner's syndrome due to superior-mediastinal schwannoma. (3236027)
1988
46
Klinefelter's syndrome associated with mediastinal germ cell neoplasms. (3040921)
1987
47
Circumflex retroesophageal right aortic arch simulating mediastinal tumor or dissecting aneurysm. (3484865)
1986
48
Pulmonary artery occlusion following fibrosing mediastinitis due to histoplasmosis. (421398)
1979
49
Right aortic arch simulating a mediastinal tumor: a case report. (14428443)
1959
50
An unusual case of paroxysmal auricular fibrillation due to mediastinal malignant lymphoma. (14818942)
1951

Genetic Variations for Mediastinitis

About this section

Expression for genes affiliated with Mediastinitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Pathways for genes affiliated with Mediastinitis

About this section
Sources:
51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 53Reactome
See all sources

Pathways related to Mediastinitis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CSF3, JAK2, STAT6, NFKB1, MYC, IL13
2
Development PDGF signaling via STATs and NF-kB
Hide members
10.5REL, MYC, NFKB1, STAT6, JAK2
310.5TP53, BCL6, PAX5, REL, MYC, NFKB1
4
Hide members
10.5CSF3, JAK2, STAT6, NFKB1, IL13, TP53
5
Hide members
10.5STAT6, NFKB1, REL, IL13, BCL6
6
Hide members
10.5CSF3, JAK2, NFKB1, MYC, IL13, TP53
710.5IL13, MYC, STAT6, JAK2, CSF3
8
Hide members
10.5JAK2, STAT6, NFKB1, REL
9
Hide members
10.5JAK2, STAT6, NFKB1, IL13
10
Hide members
10.5MYC, NFKB1, STAT6, JAK2
1110.5JAK2, STAT6, NFKB1, MYC
12
Hide members
10.5JAK2, STAT6, NFKB1, MYC
13
Hide members
10.5REL, MYC, NFKB1, JAK2
14
Development Prolactin receptor signaling
Hide members
10.5JAK2, NFKB1, MYC, REL
15
Immune response IL-2 activation and signaling pathway
Hide members
10.5JAK2, NFKB1, MYC, REL
1610.5TP53, IL13, NFKB1, AFP
17
Hide members
10.5TP53, MYC, NFKB1, STAT6
1810.5NFKB1, MYC, REL, TP53
19
Hide members
10.5TP53, REL, MYC, NFKB1
2010.5CSF3, JAK2, NFKB1, MYC, TP53
21
Cytokine production by Th17 cells in CF (Mouse model)
10.5CSF3, JAK2, NFKB1, REL
2210.5NFKB1, STAT6, JAK2
23
Hide members
10.5JAK2, STAT6, NFKB1
2410.5JAK2, STAT6, NFKB1
25
Mucin expression in CF via IL-6, IL-17 signaling pathways
Hide members
10.5REL, NFKB1, JAK2
26
Hide members
10.5REL, NFKB1, JAK2
27
Immune response Bacterial infections in normal airways
10.5JAK2, NFKB1, REL
2810.5REL, MYC, NFKB1
29
Development A3 receptor signaling
Hide members
10.5NFKB1, MYC, REL
30
Hide members
10.5NFKB1, MYC, BCL6, TP53
31
Transcription P53 signaling pathway
Hide members
10.5TP53, REL, NFKB1
32
Hide members
10.5TP53, REL, NFKB1
33
Development EPO-induced Jak-STAT pathway
Hide members
10.5JAK2, NFKB1, MYC
34
Hide members
10.5TP53, NFKB1, JAK2
35
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.5TP53, NFKB1, JAK2
36
Hide members
10.5IL13, STAT6
37
Hide members
10.5NFKB1, MYC, TP53
3810.5TP53, MYC, NFKB1
39
Hide members
10.5TP53, MYC, NFKB1
4010.5NFKB1, MYC, BCL6
4110.5NFKB1, REL

Compounds for genes affiliated with Mediastinitis

About this section
Sources:
44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Mediastinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.0TP53, CSF3, TNFAIP2, JAK2, STAT6, AFP
2tyrosine4411.0CSF3, JAK2, STAT6, AFP, MYC, REL
3dexamethasone44 49 28 1114.0IL13, REL, MYC, AFP, STAT6
4serine4411.0JAK2, STAT6, AFP, IL4I1, IL13
5actinomycin d4411.0JAK2, STAT6, AFP, MYC, IL13, TP53
6hydroxyurea44 49 1113.0CSF3, JAK2, MYC, IL13, TP53
7oligonucleotide4411.0JAK2, STAT6, AFP, MYC, REL, PAX5
8vincristine44 49 1113.0CSF3, AFP, MYC, BCL6, TP53
9cyclophosphamide44 49 1113.0CSF3, AFP, IL13, BCL6, TP53
10doxorubicin44 49 1113.0CSF3, AFP, MYC, IL13, BCL6, TP53
11cytidine44 11 2412.9BCL6, PAX5, MYC, STAT6
1210-hydroxycamptothecin4410.9AFP, MYC, TP53
13paraffin4410.9AFP, MYC, PAX5, BCL6, ALPPL2, TP53
14thymidine44 2411.9CSF3, JAK2, AFP, MYC, IL13, TP53
15melphalan44 1111.9CSF3, MYC, IL4I1, TP53
16rituximab44 49 1112.9CSF3, IL13, PAX5, BCL6
17bleomycin44 1111.9CSF3, AFP, IL13, TP53
18etoposide44 49 59 1113.9TP53, MYC, NFKB1, AFP, CSF3
19amifostine44 1111.9CSF3, ALPPL2, TP53
20mg 13244 5911.9JAK2, STAT6, MYC, TP53
21adriamycin4410.9TP53, MYC, AFP, CSF3
225-aza-2deoxycytidine4410.9JAK2, MAL, MYC, TP53
23cyclosporin a44 28 5912.9IL13, REL, MYC, JAK2, CSF3
24threonine4410.9JAK2, STAT6, AFP, MYC, REL, IL13
25butyrate4410.9JAK2, ALPPL2
26imatinib44 49 1112.9CSF3, JAK2, MYC, BCL6
27vegf4410.9CSF3, JAK2, AFP, MYC, IL13, TP53
28tachyplesin i4410.9MYC, AFP
29estrogen4410.9BCL6
30tanshinone iia4410.8MYC, TP53
31anti-fungal4410.8REL, AFP, CSF3
32cisplatin44 49 59 1113.8CSF3, JAK2, AFP, MYC, TP53
33chloramphenicol44 2 1112.8IL13, REL, MYC, AFP
34leucine4410.8JAK2, MLLT10, MYC, IL4I1, ALPPL2
35vinblastine44 49 1112.8TP53, AFP
36acnu4410.8TP53, CSF3
37irinotecan44 49 1112.8CSF3, AFP, TP53
38acetaminophen44 2 49 11 2414.8IL13, MYC, AFP
39n acetylcysteine4410.8JAK2, STAT6, MYC, TP53
40carboplatin44 49 1112.7TP53, AFP, CSF3
41aclarubicin4410.7CSF3, MYC
42sb 20358044 5911.7JAK2, STAT6, IL13, TP53
434-hydroperoxycyclophosphamide4410.7CSF3, MYC
44thalidomide44 49 59 1113.7IL13, NFKB1, AFP
45h2o24410.6JAK2, AFP, IL4I1, IL13, TP53
46vesnarinone4410.6MYC, CSF3
47paclitaxel44 49 1112.5CSF3, AFP, MYC, TP53
48mitomycin c4410.5TP53, AFP, CSF3
49gemcitabine44 49 1112.4TP53, MYC, CSF3
50gp 1304410.2CSF3, JAK2, IL13

GO Terms for genes affiliated with Mediastinitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.5TP53, BCL6

Biological processes related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:00012210.5TP53, FOXN1, STAT6, NFKB1, MYC, PAX5
2positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5TP53, JAK2, CSF3
3positive regulation of transcription from RNA polymerase II promoterGO:04594410.4CSF3, STAT6, MLLT10, NFKB1, MYC, PAX5
4negative regulation of type 2 immune responseGO:00282910.2BCL6, STAT6

Molecular functions related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:00813410.5TP53, MYC, NFKB1, FOXN1
2sequence-specific DNA binding transcription factor activityGO:00370010.2TP53, STAT6, MLLT10, NFKB1, MYC, REL

Products for genes affiliated with Mediastinitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mediastinitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet