Aliases & Classifications for Mediastinitis

Aliases & Descriptions for Mediastinitis:

Name: Mediastinitis 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:819
ICD10 33 J98.5
ICD9CM 35 519.2
MeSH 42 D008480
NCIt 47 C26827
SNOMED-CT 64 47597000
UMLS 69 C0025064

Summaries for Mediastinitis

MalaCards based summary : Mediastinitis is related to pericarditis and artery disease, and has symptoms including chest pain and signs and symptoms. An important gene associated with Mediastinitis is MPO (Myeloperoxidase), and among its related pathways/superpathways are Folate Metabolism and FOXA1 transcription factor network. The drugs Ticlopidine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include b cells, lymph node and lung, and related phenotypes are Increased shRNA abundance and cardiovascular system

Wikipedia : 71 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

Related Diseases for Mediastinitis

Diseases related to Mediastinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 494)
id Related Disease Score Top Affiliating Genes
1 pericarditis 29.6 CRP F5 INS
2 artery disease 29.3 CRP NKX2-6
3 myocardial infarction 29.1 CRP F5 INS MPO
4 chondroma 28.9 CRP INS
5 fibrosing mediastinitis 12.3
6 primary mediastinal large b-cell lymphoma 12.1
7 mediastinal cancer 11.9
8 malignant mediastinal neurogenic neoplasm 11.9
9 mediastinal lipomatosis 11.9
10 mediastinal gray zone lymphoma 11.9
11 mediastinal malignant lymphoma 11.9
12 mediastinal endodermal sinus tumors 11.9
13 mediastinal neurilemmoma 11.9
14 childhood mediastinal neurogenic tumor 11.7
15 mediastinal granular cell myoblastoma 11.7
16 mediastinal osteogenic sarcoma 11.7
17 benign mediastinal psammomatous neurilemmoma 11.7
18 benign mediastinal neurilemmoma 11.7
19 mediastinal mesenchymal tumor 11.7
20 gray zone lymphoma 11.1
21 igg4-related disease 11.0
22 dyserythropoietic anemia, congenital, type ii 10.8
23 lipomatosis, multiple symmetric 10.8
24 mediastinum neuroblastoma 10.8
25 mediastinum sarcoma 10.8
26 aortopulmonary window 10.8
27 malignant melanocytic peripheral nerve sheath tumor of mediastinum 10.7
28 lymphoma 10.5
29 b-cell lymphomas 10.4
30 teratoma 10.3
31 cannabis dependence 10.2 CRP MPO
32 adenoma 10.2
33 acro coxo mesomelic dysplasia 10.2 CRP F5
34 tuberculous salpingitis 10.2 CRP MPO
35 subacute glomerulonephritis 10.2 CRP MPO
36 parathyroid adenoma 10.2
37 cyclotropia 10.2 CRP MPO
38 dermatomycosis 10.2 CRP MPO
39 houlston ironton temple syndrome 10.2 CRP F5
40 scalp dermatosis 10.2 CRP MPO
41 esotropia 10.2 CRP MPO
42 intestinal disaccharidase deficiency 10.2 CRP F5
43 acute infection of pinna 10.1 CRP INS
44 hypolipoproteinemia 10.1 CRP MPO
45 cataract 10.1 CRP INS
46 autoimmune disease 1 10.1 CRP INS
47 urticaria 10.1 CRP MPO
48 joint disorders 10.1 CRP INS
49 iida kannari syndrome 10.1 INS MPO
50 bronchogenic cyst 10.1

Comorbidity relations with Mediastinitis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to Mediastinitis

Symptoms & Phenotypes for Mediastinitis

UMLS symptoms related to Mediastinitis:


chest pain, signs and symptoms

GenomeRNAi Phenotypes related to Mediastinitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 F5 INS RERE

MGI Mouse Phenotypes related to Mediastinitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 RERE CRP DNM1 F5 INS MPO
2 embryo MP:0005380 9.02 F5 INS MAPKAPK3 NKX2-6 RERE

Drugs & Therapeutics for Mediastinitis

Drugs for Mediastinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticlopidine Approved Phase 4 55142-85-3 5472
2
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
3
Clopidogrel Approved, Nutraceutical Phase 4 120202-66-6, 113665-84-2 60606
4 tannic acid Approved, Nutraceutical Phase 4
5 Coagulants Phase 4
6 Hemostatics Phase 4
7 Neurotransmitter Agents Phase 4
8 Cytochrome P-450 Enzyme Inhibitors Phase 4
9 Platelet Aggregation Inhibitors Phase 4
10 Fibrinolytic Agents Phase 4
11 Purinergic P2 Receptor Antagonists Phase 4
12 Purinergic P2Y Receptor Antagonists Phase 4
13 insulin Phase 4
14 Hypoglycemic Agents Phase 4
15 Insulin, Globin Zinc Phase 4
16 Vaccines Phase 2, Phase 3
17
Vancomycin Approved 1404-90-6 441141 14969
18
Cefuroxime Approved 55268-75-2 5361202 5479529
19 Anti-Bacterial Agents
20 Antibiotics, Antitubercular
21 methicillin
22 cefuroxime axetil
23 Anti-Infective Agents

Interventional clinical trials:

(show all 19)
id Name Status NCT ID Phase
1 Improvement of Hemostasis Techniques After Median Sternotomy Unknown status NCT01134471 Phase 4
2 Rapid Sternal Closure System (TALON) Completed NCT00638014 Phase 4
3 Evaluation of Primary Plating in Sternotomy Patients for Osteosynthesis and Pain Completed NCT00819286 Phase 4
4 Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery. Completed NCT00724880 Phase 4
5 Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery Terminated NCT00394303 Phase 4
6 SOLAR & ATRILAZE Atrial Fibrillation Trial Unknown status NCT00734058 Phase 3
7 Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2) Terminated NCT00518687 Phase 2, Phase 3
8 The eMESH 1 Feasibility Study Recruiting NCT01676376 Phase 1, Phase 2
9 Delayed Primary Versus Late Secondary Wound Closure in Sternum Infections Unknown status NCT01473979
10 Endoscopic-vacuum Assisted Closure of Intrathoracic Postsurgical Leaks Unknown status NCT00876551
11 Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft Completed NCT00711685
12 Physiotherapy Exercises in Patients With Sternal Instability After Cardiovascular Surgery Completed NCT02513576
13 Perioperative Intra-Aortic Balloon Pump (IABP) in Coronary Artery Bypass Grafting (CABG) Operations in Patients With Severely Depressed Left Ventricular Function Completed NCT00881192
14 Pharmacokinetics of Cefuroxime in Cardiac Surgery With Cardiopulmonary Bypass Completed NCT01228825
15 Factors Associated With Complications of Cervical Necrotizing Fasciitis Recruiting NCT02847234
16 Intra-aortic Balloon Counterpulsation in Patients Undergoing Cardiac Surgery Recruiting NCT02143544
17 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2 Active, not recruiting NCT02073760
18 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery Active, not recruiting NCT02068716
19 Effects of a New Antimicrobial Dressing on Wound Healing and Incidence of Sternal Wound Infections Terminated NCT00203541

Search NIH Clinical Center for Mediastinitis

Cochrane evidence based reviews: mediastinitis

Genetic Tests for Mediastinitis

Anatomical Context for Mediastinitis

MalaCards organs/tissues related to Mediastinitis:

39
B Cells, Lymph Node, Lung, Heart, Thyroid, Bone, Myeloid

Publications for Mediastinitis

Articles related to Mediastinitis:

(show top 50) (show all 2097)
id Title Authors Year
1
Mediastinal seminoma associated with multilocular thymic cyst. ( 28054283 )
2017
2
Resection of giant mediastinal liposarcoma via 'a8L shape' incision. ( 28044001 )
2017
3
Benign cystic mediastinal teratoma presenting as a massive pleural effusion in a 17-year-old boy. ( 28073871 )
2017
4
Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association. ( 27758822 )
2017
5
Repeated loss of target surface antigen after immunotherapy in primary mediastinal large B cell lymphoma. ( 27779774 )
2017
6
Role of Transbronchial Needle Aspiration (Conventional and EBUS Guided) in the Diagnosis of Histoplasmosis in Patients Presenting with Mediastinal Lymphadenopathy. ( 28052172 )
2017
7
European Association for Cardio-Thoracic Surgery expert consensus statement on the prevention and management of mediastinitis. ( 28077503 )
2017
8
Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma. ( 27879516 )
2017
9
Second cancer risk assessments after involved-site radiotherapy for mediastinal Hodgkin lymphoma. ( 28493609 )
2017
10
Primary mediastinal clear cell sarcoma: a case report and review of the literature. ( 28086809 )
2017
11
Mediastinal cyst of mA1llerian origin: evidence for developmental endosalpingiosis. ( 27913049 )
2017
12
Myasthenia Gravis, Mediastinal Goiter, and Crohn's Disease. ( 28528037 )
2017
13
A case report of mediastinal ectopic parathyroid adenoma presented as parathyroid crisis localized by SPECT/CT. ( 27741147 )
2016
14
Video Assisted Thoracoscopic Surgery (VATS) for Excision of an Ectopic Anterior Mediastinal Intra-Thymic Parathyroid Adenoma. ( 27504353 )
2016
15
Invasive Esophageal Candidiasis with Chronic Mediastinal Abscess and Fatal Pneumomediastinum. ( 27389822 )
2016
16
An uncommon presentation of Kikuchi-Fujimoto disease as mediastinal lymphadenopathy. ( 27162693 )
2016
17
Primary Mediastinal Large B-cell Lymphoma Exhibiting Endobronchial Involvement. ( 27803409 )
2016
18
Candida famata mediastinitis. A rare complication of open heart surgery. Case report and brief review. ( 27419075 )
2016
19
Descending necrotizing mediastinitis complicating hyperimmunoglobulin E syndrome. ( 27512566 )
2016
20
Mediastinal giant parathyroid adenoma-a minimally invasive mediastinal surgical approach for an emergency presentation. ( 26904438 )
2016
21
Severe descending necrotizing mediastinitis: vacuum-assisted dressing did wonder. ( 27016203 )
2016
22
A Case of Nocardia farcinica Pneumonia and Mediastinitis in an Immunocompetent Patient. ( 27066088 )
2016
23
Rare mediastinal leiomyoma in a child. ( 27640051 )
2016
24
Surgical treatment for mediastinal parathyroid adenoma causing primary hyperparathyroidism. ( 27056365 )
2016
25
Mediastinitis, pseudo-aneurysm formation, aortic bleed, and death from endoscopic botulinum toxin injection. ( 27213973 )
2016
26
The immunophenotypic spectrum of primary mediastinal large B-cell lymphoma reveals prognostic biomarkers associated with outcome. ( 27419920 )
2016
27
Primary Mediastinal Large B-Cell Lymphoma With Translocations Involving BCL6 and MYC (Double-Hit Lymphoma). ( 27124935 )
2016
28
A single-institution retrospective analysis of outcomes for stage I-II primary mediastinal large B-cell lymphoma treated with immunochemotherapy with or without radiotherapy. ( 26159046 )
2016
29
Mediastinal nodular AL-amyloidosis with progressive calcification. ( 27521579 )
2016
30
Ludwig's angina complicated by fatal cervicofascial and mediastinal necrotizing fasciitis. ( 27077024 )
2016
31
Mediastinal Lipomatosis with Dyslipidemia: Cause of Dyspnea. ( 27805346 )
2016
32
Mediastinal bronchogenic cyst mimicking congenital lobar emphysema. ( 27609589 )
2016
33
Traumatic Rupture of A Posterior Mediastinal Teratoma following Motor-Vehicle Accident. ( 27660731 )
2016
34
Clinical Manifestations of Fibrosing Mediastinitis in Chinese Patients. ( 27824002 )
2016
35
Primary mediastinal large B-cell lymphoma: transcriptional regulation by miR-92a through FOXP1 targeting. ( 27806315 )
2016
36
Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? ( 26957476 )
2016
37
A case of anterior mediastinitis and bilateral multiple lung abscesses occurring after trans-subxiphoid video-assisted thoracoscopic extended thymectomy for thymoma with myasthenia gravis. ( 27747038 )
2016
38
Primary mediastinal dedifferentiated liposarcoma resected by lateral thoracotomy with video-assisted thoracoscopic surgery. ( 26724326 )
2016
39
Clinicopathological characteristics of mediastinal follicular dendritic cell sarcoma: report of three cases. ( 27068522 )
2016
40
Bilateral mammary artery grafting increases postoperative mediastinitis without survival benefit in obese patients. ( 27229669 )
2016
41
Surgical treatment of mediastinitis with omentoplasty in ventricular assist device patients: report of referral center experience. ( 27465093 )
2016
42
Primary Mediastinal Synovial Sarcoma with subsequent development of Primary Adenoid Cystic Carcinoma of Lung presenting as superior vena cava syndrome. ( 26992072 )
2016
43
Chylopericardium presenting as cardiac tamponade secondary to mediastinal lymphangioma. ( 27388545 )
2016
44
An Unusual Cause of Airway Compromise in the Emergency Department: Mediastinal Bronchogenic Cyst. ( 27986331 )
2016
45
Three-stage treatment of late mediastinitis after implantation of left ventricular assist device. ( 27017437 )
2016
46
Perioperative Morbidity and Mortality Associated With Bleomycin in Primary Mediastinal Nonseminomatous Germ Cell Tumor. ( 27621392 )
2016
47
Pyoderma gangrenosum mimicking mediastinitis after cardiac surgery: a case study. ( 27286670 )
2016
48
Mediastinal Mass with Hyper-eosinophilia in a Young Boy -A Diagnostic Dilemma. ( 27630938 )
2016
49
Pleural irregularities and mediastinal pleural involvement in early stages of malignant pleural mesothelioma and benign asbestos pleural effusion. ( 27501894 )
2016
50
Bilateral simultaneous VATS for complete resection of bilateral posterior mediastinal bronchogenic cyst: A case report. ( 27710876 )
2016

Variations for Mediastinitis

Expression for Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Pathways for Mediastinitis

Pathways related to Mediastinitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 CRP INS MPO
2
Show member pathways
10.62 CYP2C18 INS

GO Terms for Mediastinitis

Cellular components related to Mediastinitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 8.62 F5 INS

Biological processes related to Mediastinitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.96 CRP INS
2 negative regulation of vasodilation GO:0045908 8.62 CRP INS

Sources for Mediastinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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