MCID: MDS022
MIFTS: 56

Mediastinitis malady

Summaries for Mediastinitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

MalaCards: Mediastinitis is related to seminoma and sarcoma. An important gene associated with Mediastinitis is TNFAIP2 (tumor necrosis factor, alpha-induced protein 2), and among its related pathways are Rho Family GTPases and Development PDGF signaling via STATs and NF-kB. The compounds retinoic acid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include b cells, lymph node and lung, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Mediastinitis

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 27ICD9CM, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

mediastinitis 8 10 60


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Disease Ontology8 DOID:819
NCIt39 C26827
SNOMED-CT56 47597000
ICD9CM27 519.2
MeSH34 D008480

Related Diseases for Mediastinitis

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17GeneCards, 18GeneDecks
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Diseases related to Mediastinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 489)
idRelated DiseaseScoreTop Affiliating Genes
1seminoma30.7ALPPL2, AFP
2sarcoma30.7TP53, JAK2
3esophagitis30.7IL13
4leukemia30.5CSF3, JAK2, MLLT10, NFKB1, MYC, REL
5lung cancer30.5CSF3, MYC, TP53
6hodgkin's lymphoma30.4CSF3, JAK2, STAT6, REL, IL13, PAX5
7diffuse large b-cell lymphoma30.4MUM1
8acute leukemia30.3CSF3, JAK2, MLLT10, PAX5
9pancreatitis30.3ALPPL2
10graves' disease30.2IL13, STAT6
11myeloid leukemia30.2MYC, MLLT10, JAK2, CSF3
12lung small cell carcinoma30.2CSF3, MYC, PAX5, TP53
13plasmacytoma30.2MYC, PAX5, BCL6
14endodermal sinus tumor30.2AFP, ALPPL2
15hyperparathyroidism30.2ALPPL2
16choriocarcinoma30.1ALPPL2, AFP, JAK2
17adenocarcinoma30.1JAK2, AFP, MYC, TP53
18neuroblastoma30.1TP53, MYC
19hypercalcemia30.1ALPPL2
20burkitt's lymphoma29.9CSF3, JAK2, STAT6, MYC, REL, PAX5
21hepatitis29.9AFP
22anaplastic large cell lymphoma29.8BCL6, PAX5
23arthritis29.8STAT6, IL13, ALPPL2
24down syndrome29.8JAK2, AFP
25bronchiolitis29.8IL13
26myeloma29.6CSF3, JAK2, MYC, PAX5, BCL6, ALPPL2
27breast cancer29.6CSF3, JAK2, STAT6, NFKB1, MYC, REL
28rheumatoid arthritis29.6JAK2, STAT6, CD274, IL13
29multiple myeloma29.6TP53, CSF3
30non-hodgkin lymphoma29.6CSF3, JAK2, MYC, PAX5, BCL6
31colon cancer29.6JAK2, STAT6, MYC, ALPPL2, TP53
32central nervous system lymphoma29.6BCL6
33glioblastoma multiforme29.6JAK2, STAT6, MYC, IL13, TP53
34atherosclerosis29.6STAT6
35astrocytoma29.6TP53, PAX5, IL13
36dilated cardiomyopathy29.6STAT6
37hyperthyroidism29.6ALPPL2
38malt lymphoma29.6BCL6
39esophageal cancer29.6TP53
40adenoma10.6
41parathyroid adenoma10.6
42mediastinal cancer10.5
43mediastinal lipomatosis10.5
44lipomatosis10.5
45cervicitis10.4
46goiter10.4
47lymphangioma10.4
48lymphadenitis10.4
49mature teratoma10.4
50liposarcoma10.4

Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to mediastinitis

Clinical Features for Mediastinitis

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Drugs & Therapeutics for Mediastinitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mediastinitis

Drug clinical trials:

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Search NIH Clinical Center for Mediastinitis

Search CenterWatch for Mediastinitis

Genetic Tests for Mediastinitis

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Anatomical Context for Mediastinitis

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32MalaCards
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MalaCards organs/tissues related to Mediastinitis:

32
B cells, Lymph node, Lung, Heart, Thyroid, Myeloid, T cells, Bone, Liver, Skin, Breast, Colon, Tonsil, Trachea, Bone marrow, Thymus, Spinal cord, Prostate, Testes, Kidney, Ovary, Monocytes, Brain, Pancreas, Spleen, Pituitary

Animal Models for Mediastinitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mediastinitis:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.8TP53, CSF3, FOXN1, JAK2, STAT6, NFKB1
2MP:000538710.8CSF3, FOXN1, JAK2, STAT6, NFKB1, MYC
3MP:000538410.8FOXN1, JAK2, STAT6, NFKB1, MYC, CD274
4MP:001077110.8FOXN1, STAT6, MYC, REL, IL13, TP53
5MP:001076810.8NFKB1, AFP, STAT6, JAK2, FOXN1, MYC
6MP:000537610.7FOXN1, JAK2, STAT6, AFP, NFKB1, MYC
7MP:000539010.7FOXN1, JAK2, MYC, PAX5
8MP:000537010.7FOXN1, STAT6, NFKB1, MYC, REL, BCL6
9MP:000538910.6FOXN1, STAT6, AFP, MYC, IL13, TP53
10MP:000537810.6FOXN1, JAK2, STAT6, NFKB1, MYC, REL
11MP:000537710.5IL13, FOXN1
12MP:000200610.4FOXN1, STAT6, AFP
13MP:000537910.2TP53, MYC, AFP, JAK2, FOXN1

Publications for Mediastinitis

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50PubMed
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Articles related to Mediastinitis:

(show top 50)    (show all 1742)
idTitleAuthorsYear
1
Tuberculosis vs. chronic lymphocytic leukaemia in mediastinal lymph nodes using computed tomography. (24429315)
2014
2
Embryonal rhabdomyosarcoma arising from a mediastinal teratoma: an unusual case report. (23487585)
2013
3
Facial paralysis and mediastinitis due to odontogenic infection and poor prognosis. (24220381)
2013
4
Propolis-induced descending necrotizing mediastinitis and aspiration pneumonia. (23522239)
2013
5
Descending necrotizing Mediastinitis caused by Kocuria rosea: a case report. (24112281)
2013
6
Open reduction internal fixation poststernotomy mediastinitis. (23970966)
2013
7
Fatal mediastinitis following botulinum toxin injection for esophageal spasm. (24285073)
2013
8
Differentiation of lymphoma versus sarcoidosis in the setting of mediastinal-hilar lymphadenopathy: assessment with diffusion-weighted MR imaging. (24003535)
2013
9
Cardiac tamponade as a manifestation of acute mediastinitis. (23606298)
2013
10
Proteus Mediastinitis Causing Fatal Pseudoaneurysm following Aortic Valve Replacement. (24369472)
2013
11
Floating left innominate vein neoplastic thrombus: A rare case of mediastinal extension of follicular thyroid carcinoma. (24335091)
2013
12
Anterior mediastinal paraganglioma: a case for preoperative embolization. (22759641)
2012
13
A rare case of bilateral massive hemothorax from spontaneous rupture of a primary mediastinal mixed germ cell tumor. (22269740)
2012
14
Chest wall stabilization following mediastinitis. (21885564)
2011
15
Primary mediastinal large B-cell lymphoma (PMLBCL) in Chinese patients: clinical characteristics and prognostic factors. (21800075)
2011
16
Treatment of severe mediastinitis following cardiac surgery with omental flaps. (22696731)
2011
17
Unusual cause of right ventricular outflow tract compression: mediastinal lipomatosis. (21052024)
2011
18
Successfully treated descending necrotizing mediastinitis through thoracotomy using a pedicled muscular serratus anterior flap. (21791516)
2011
19
Mediastinal mature cystic teratoma perforating into the lung. (20876619)
2010
20
Mediastinal lymphangiomyoma in an adult: Report of a case. (20339992)
2010
21
Risk score elaboration for mediastinitis after coronary artery bypass grafting. (20802905)
2010
22
Postoperative mediastinitis in cardiovascular surgery postoperation. Analysis of 1038 consecutive surgeries. (20563463)
2010
23
Symptomatic compression of the pulmonary artery by a posterior mediastinal bronchogenic cyst. (21095296)
2010
24
Extraluminal cardiac paraganglioma: unexpected diagnosis of a large mediastinal mass. (20153211)
2010
25
A large pericardial cyst complicated by a pericarditis in a young man with a mediastinal mass. (19632370)
2009
26
Spontaneous regression of a mediastinal thymoma. (19380006)
2009
27
Lecompte's closed drainage method combined with omentoplasty: an elective treatment for acute mediastinitis after prosthetic replacement of the ascending aorta?--two successfully treated cases. (19341214)
2009
28
Mediastinitis and mediastinitis-like symptoms associated with mal-positioning of a Port-A catheter. (19473373)
2009
29
Multidrug-resistant Klebsiella pneumoniae mediastinitis safely and effectively treated with prolonged administration of tigecycline. (18540810)
2008
30
Vacuum-assisted closure for mediastinitis after pediatric cardiac surgery. (18812337)
2008
31
Mediastinal pleomorphic liposarcoma diagnosed by fine needle aspiration biopsy: a case report. (17536551)
2007
32
Descending necrotizing mediastinitis: treatment of a delayed case. (17966551)
2007
33
Descending mediastinitis: a review. (17262162)
2006
34
An esophagobronchial fistula caused by an unusual foreign body in the esophagus leading to mediastinitis with fatal outcome. (16506109)
2006
35
Late presentation of poststernotomy mediastinitis 15 years after coronary artery bypass grafting. (17062271)
2006
36
Downregulation of internal enhancer activity contributes to abnormally low immunoglobulin expression in the MedB-1 mediastinal B-cell lymphoma cell line. (15682441)
2005
37
Ectopic mediastinal thyroid adenoma. (15201004)
2004
38
Lateral position prevents respiratory occlusion during surgical procedure under general anesthesia in the patient of huge anterior mediastinal lymphoblastic lymphoma. (15552973)
2004
39
Sternoclavicular joint infection and mediastinitis originally attributed to concomitant rotator cuff pathology. (15553955)
2004
40
Baritosis of the mediastinal lymph nodes. (12842570)
2003
41
Fibrosing mediastinitis and thrombosis of superior vena cava associated with BehAset's disease. (14680916)
2003
42
Case report: Spinal cord herniation into a mediastinal neurenteric cyst: CT and MRI findings. (12642283)
2003
43
Thymic hyperplasia presenting as anterior mediastinal mass in 2 patients with Graves disease. (12005000)
2002
44
Mediastinal lipomatosis. (9853734)
1998
45
Primary germ cell tumors of the mediastinum: II. Mediastinal seminomas--a clinicopathologic and immunohistochemical study of 120 cases. (9264352)
1997
46
Enlarged mediastinal lymph nodes in bronchogenic carcinoma: assessment with dynamic contrast-enhanced MR imaging. Work in progress. (8134585)
1994
47
Mediastinal lipomatosis: a complication of high dose steroid therapy in children. (3222066)
1988
48
Embryonal rhabdomyosarcoma of the hand. A case of mediastinal relapse 103 months after treatment. (6705329)
1984
49
Retropharyngeal abscess, mediastinitis, and pleural effusion complicating streptococcal facial erysipelas. (7022666)
1981
50
Mediastinal germ cell cancers in Klinefelter's syndrome. (7469226)
1981

Genetic Variations for Mediastinitis

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Expression for genes affiliated with Mediastinitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Pathways for genes affiliated with Mediastinitis

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51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 53Reactome
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Pathways related to Mediastinitis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CSF3, JAK2, STAT6, NFKB1, MYC, IL13
2
Development PDGF signaling via STATs and NF-kB
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10.5REL, MYC, NFKB1, STAT6, JAK2
310.5TP53, BCL6, PAX5, REL, MYC, NFKB1
4
Hide members
10.5CSF3, JAK2, STAT6, NFKB1, IL13, TP53
5
Hide members
10.5STAT6, NFKB1, REL, IL13, BCL6
6
Hide members
10.5CSF3, JAK2, NFKB1, MYC, IL13, TP53
710.5IL13, MYC, STAT6, JAK2, CSF3
8
Hide members
10.5JAK2, STAT6, NFKB1, REL
9
Hide members
10.5JAK2, STAT6, NFKB1, IL13
10
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10.5MYC, NFKB1, STAT6, JAK2
1110.5JAK2, STAT6, NFKB1, MYC
12
Hide members
10.5JAK2, STAT6, NFKB1, MYC
13
Hide members
10.5REL, MYC, NFKB1, JAK2
14
Development Prolactin receptor signaling
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10.5JAK2, NFKB1, MYC, REL
15
Immune response IL-2 activation and signaling pathway
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10.5JAK2, NFKB1, MYC, REL
1610.5TP53, IL13, NFKB1, AFP
17
Hide members
10.5TP53, MYC, NFKB1, STAT6
1810.5NFKB1, MYC, REL, TP53
19
Hide members
10.5TP53, REL, MYC, NFKB1
2010.5CSF3, JAK2, NFKB1, MYC, TP53
21
Cytokine production by Th17 cells in CF (Mouse model)
10.5CSF3, JAK2, NFKB1, REL
2210.5NFKB1, STAT6, JAK2
23
Hide members
10.5JAK2, STAT6, NFKB1
2410.5JAK2, STAT6, NFKB1
25
Mucin expression in CF via IL-6, IL-17 signaling pathways
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10.5REL, NFKB1, JAK2
26
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10.5REL, NFKB1, JAK2
27
Immune response Bacterial infections in normal airways
10.5JAK2, NFKB1, REL
2810.5REL, MYC, NFKB1
29
Development A3 receptor signaling
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10.5NFKB1, MYC, REL
30
Hide members
10.5NFKB1, MYC, BCL6, TP53
31
Transcription P53 signaling pathway
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10.5TP53, REL, NFKB1
32
Hide members
10.5TP53, REL, NFKB1
33
Development EPO-induced Jak-STAT pathway
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10.5JAK2, NFKB1, MYC
34
Hide members
10.5TP53, NFKB1, JAK2
35
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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10.5TP53, NFKB1, JAK2
36
Hide members
10.5IL13, STAT6
37
Hide members
10.5NFKB1, MYC, TP53
3810.5TP53, MYC, NFKB1
39
Hide members
10.5TP53, MYC, NFKB1
4010.5NFKB1, MYC, BCL6
4110.5NFKB1, REL

Compounds for genes affiliated with Mediastinitis

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 2BitterDB
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Compounds related to Mediastinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.0TP53, CSF3, TNFAIP2, JAK2, STAT6, AFP
2tyrosine4411.0REL, MYC, AFP, STAT6, JAK2, CSF3
3dexamethasone44 49 28 1114.0STAT6, AFP, MYC, REL, IL13
4serine4411.0IL4I1, STAT6, AFP, IL13, JAK2
5actinomycin d4411.0TP53, AFP, STAT6, JAK2, MYC, IL13
6hydroxyurea44 49 1113.0MYC, CSF3, JAK2, TP53, IL13
7oligonucleotide4411.0REL, PAX5, JAK2, STAT6, AFP, MYC
8vincristine44 49 1113.0CSF3, AFP, MYC, BCL6, TP53
9cyclophosphamide44 49 1113.0AFP, TP53, IL13, BCL6, CSF3
10doxorubicin44 49 1113.0TP53, BCL6, MYC, CSF3, AFP, IL13
11cytidine44 11 2412.9MYC, PAX5, BCL6, STAT6
1210-hydroxycamptothecin4410.9MYC, TP53, AFP
13paraffin4410.9PAX5, AFP, BCL6, ALPPL2, MYC, TP53
14thymidine44 2411.9TP53, MYC, CSF3, IL13, AFP, JAK2
15melphalan44 1111.9IL4I1, TP53, CSF3, MYC
16rituximab44 49 1112.9IL13, PAX5, CSF3, BCL6
17bleomycin44 1111.9IL13, AFP, TP53, CSF3
18etoposide44 49 59 1113.9AFP, TP53, MYC, CSF3, NFKB1
19amifostine44 1111.9ALPPL2, CSF3, TP53
20mg 13244 5911.9MYC, JAK2, TP53, STAT6
21adriamycin4410.9AFP, MYC, TP53, CSF3
225-aza-2deoxycytidine4410.9MYC, TP53, JAK2, MAL
23cyclosporin a44 28 5912.9CSF3, MYC, JAK2, REL, IL13
24threonine4410.9STAT6, REL, AFP, MYC, IL13, JAK2
25butyrate4410.9ALPPL2, JAK2
26imatinib44 49 1112.9MYC, BCL6, CSF3, JAK2
27vegf4410.9AFP, MYC, IL13, TP53, CSF3, JAK2
28tachyplesin i4410.9MYC, AFP
29estrogen4410.9BCL6
30tanshinone iia4410.8MYC, TP53
31anti-fungal4410.8CSF3, AFP, REL
32cisplatin44 49 59 1113.8JAK2, TP53, AFP, CSF3, MYC
33chloramphenicol44 2 1112.8AFP, MYC, IL13, REL
34leucine4410.8MYC, MLLT10, JAK2, IL4I1, ALPPL2
35vinblastine44 49 1112.8TP53, AFP
36acnu4410.8TP53, CSF3
37irinotecan44 49 1112.8TP53, AFP, CSF3
38acetaminophen44 2 49 11 2414.8IL13, MYC, AFP
39n acetylcysteine4410.8STAT6, MYC, JAK2, TP53
40carboplatin44 49 1112.7TP53, CSF3, AFP
414-hydroperoxycyclophosphamide4410.7CSF3, MYC
42sb 20358044 5911.7JAK2, TP53, IL13, STAT6
43aclarubicin4410.7CSF3, MYC
44thalidomide44 49 59 1113.7AFP, NFKB1, IL13
45h2o24410.6IL4I1, JAK2, AFP, IL13, TP53
46vesnarinone4410.6MYC, CSF3
47paclitaxel44 49 1112.5CSF3, AFP, TP53, MYC
48mitomycin c4410.5CSF3, AFP, TP53
49gemcitabine44 49 1112.4CSF3, TP53, MYC
50gp 1304410.2JAK2, IL13, CSF3

GO Terms for genes affiliated with Mediastinitis

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16Gene Ontology
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Cellular components related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.5TP53, BCL6

Biological processes related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:00012210.5TP53, FOXN1, STAT6, NFKB1, MYC, PAX5
2positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5TP53, JAK2, CSF3
3positive regulation of transcription from RNA polymerase II promoterGO:04594410.4CSF3, STAT6, MLLT10, NFKB1, MYC, PAX5
4negative regulation of type 2 immune responseGO:00282910.2BCL6, STAT6

Molecular functions related to Mediastinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:00813410.5TP53, MYC, NFKB1, FOXN1
2sequence-specific DNA binding transcription factor activityGO:00370010.2TP53, STAT6, MLLT10, NFKB1, MYC, REL

Products for genes affiliated with Mediastinitis

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  • Antibodies
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Sources for Mediastinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet