MDB
MCID: MDL005
MIFTS: 77

Medulloblastoma (MDB) malady

Genetic diseases, Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Medulloblastoma

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Medulloblastoma is a highly malignant primary brain tumor that originates in the cerebellum or posterior... more...

MalaCards: Medulloblastoma, also known as medulloblastoma with extensive nodularity, is related to childhood medulloblastoma and basal cell carcinoma. An important gene associated with Medulloblastoma is PTCH2 (patched 2), and among its related pathways are Signaling events mediated by the Hedgehog family and TP53 network. The drug carmustine and the compounds methylazoxymethanol acetate and 1-hydroxyanthraquinone have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and bone, and related mouse phenotypes are pigmentation and hearing/vestibular/ear.

Description from OMIM:48 155255

Aliases & Classifications for Medulloblastoma

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Sources:
9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 37MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
classic medulloblastoma:
Age of onset: Childhood
desmoplastic/nodular medulloblastoma:
Inheritance: Sporadic; Age of onset: Adulthood
medulloblastoma with extensive nodularity:
Inheritance: Sporadic; Age of onset: Neonatal/infancy; Age of death: Normal
medulloblastoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

medulloblastoma 9 10 44 48 11 46 50 63
medulloblastoma with extensive nodularity 50 63
classic medulloblastoma 50 63
medulloblastomas 9 23
desmoplastic/nodular medulloblastoma 50
cerebellar neuroblastoma 50
medulloblastoma nos 9
mdb 44


External Ids:

Disease Ontology9 DOID:3858
MeSH36 D008527
OMIM48 155255
NCIt41 C3222
SNOMED-CT via Orphanet60 32456001, 443333004, 83217000
UMLS via Orphanet64 C0751291, C0025149
MESH via Orphanet37 D008527

Related Diseases for Medulloblastoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Medulloblastoma family:

Adult Medulloblastoma Medulloblastoma, Sufu-Related

Diseases related to Medulloblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1childhood medulloblastoma31.5ERBB4, ERBB3, MYC
2basal cell carcinoma30.8CTNNB1, SUFU, PTCH1
3nevoid basal cell carcinoma syndrome30.8SUFU, PTCH1, PTCH2
4meningioma30.6SSTR2, PTCH1, GFAP
5turcot syndrome30.5APC, CTNNB1
6medulloblastoma, desmoplastic30.3GFAP, PTCH1, NTRK3
7pineoblastoma30.2GFAP, SAG
8adenoma30.1CTNNB1, SSTR2, SAG, MYC, APC
9glioblastoma multiforme30.1ERBB3, GFAP, DMBT1
10malignant glioma30.1DMBT1, GFAP, SSTR2, NTRK3, ERBB3, ERBB4
11retinoblastoma30.1GFAP, APC, BRCA2, MYC, SAG
12adenocarcinoma30.0DMBT1, PTCH1, APC, BRCA2, MYC, SSTR2
13brain cancer29.9DMBT1, ERBB4, NTRK3, APC, PTCH1, GFAP
14breast cancer29.8DMBT1, PTCH1, APC, BRCA2, MYC, SSTR2
15cerebellar medulloblastoma10.8
16adult medulloblastoma10.7
17primitive neuroectodermal tumor10.7
18neuronitis10.5
19astrocytoma10.5
20rhabdoid tumor10.4
21large cell medulloblastoma10.4
22atypical teratoid rhabdoid tumor10.4
23supratentorial primitive neuroectodermal tumor10.4
24ependymoma10.4
25melanotic medulloblastoma10.4
26mutism10.3
27cerebellar astrocytoma10.3
28nodular medulloblastoma10.2
29pilocytic astrocytoma10.2
30leukemia10.2
31thyroiditis10.2
32wilms tumor10.2
33syringomyelia10.2
34cerebellar liponeurocytoma10.2
35nijmegen breakage syndrome10.2
36cerebritis10.2
37cerebellar vermis medulloblastoma10.2
38encephalitis10.2
39neuroblastoma10.2
40anaplastic astrocytoma10.2
41gardner syndrome10.1APC, CTNNB1
42basal cell carcinoma, somatic10.1PTCH1, PTCH2
43intestinal neoplasm10.1APC, CTNNB1
44juvenile polyposis syndrome10.1APC
45hepatocellular adenoma10.1APC, CTNNB1
46desmoid tumor10.1CTNNB1, APC
47papillary thyroid carcinoma10.1PTCH1, APC, CTNNB1
48familial adenomatous polyposis10.1PTCH1, APC, MYC, CTNNB1
49pineocytoma10.1SAG, GFAP
50colorectal cancer, somatic10.1CTNNB1, APC

Graphical network of the top 20 diseases related to Medulloblastoma:



Diseases related to medulloblastoma

Symptoms for Medulloblastoma

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Sources:
48OMIM
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Symptoms by clinical synopsis from OMIM:

155255

Clinical features from OMIM:

155255

Drugs & Therapeutics for Medulloblastoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Medulloblastoma

Drug clinical trials:

Search ClinicalTrials for Medulloblastoma

Search NIH Clinical Center for Medulloblastoma

Search CenterWatch for Medulloblastoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Medulloblastoma

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23GTR
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Genetic tests related to Medulloblastoma:

id Genetic test Affiliating Genes
1 Medulloblastoma23

Anatomical Context for Medulloblastoma

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34MalaCards
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MalaCards organs/tissues related to Medulloblastoma:

34
Brain, Cerebellum, Bone, Thyroid, Bone marrow, Breast, Pituitary, Fetal brain, Myeloid, Testes, Kidney, Spinal cord, Pineal, Parietal lobe, Endothelial, T cells, Liver, Heart, Skin, Colon

Animal Models for Medulloblastoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Medulloblastoma:

38 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.1PTCH1, APC, SUFU, MYC, ERBB3, CTNNB1
2MP:000537710.1DMBT1, APC, MYC, SRRM4, NTRK3, CTNNB1
3MP:000537110.0CTNNB1, MYC, BRCA2, APC, PTCH1
4MP:000200610.0DMBT1, PTCH2, PTCH1, APC, SUFU, BRCA2
5MP:00053829.9PTCH1, APC, SUFU, MYC, ERBB4, CTNNB1
6MP:00053909.9PTCH1, APC, SUFU, BRCA2, MYC, ZIC1
7MP:00053919.9GFAP, PTCH1, APC, SAG, SSTR2, NTRK3
8MP:00053799.9PTCH1, APC, BRCA2, MYC, ERBB3, ERBB4
9MP:00107719.9PTCH2, PTCH1, APC, SUFU, BRCA2, MYC
10MP:00053699.9GFAP, PTCH2, PTCH1, APC, MYC, ZIC1
11MP:00053809.8DMBT1, PTCH1, APC, SUFU, BRCA2, MYC
12MP:00053899.8PTCH2, PTCH1, APC, BRCA2, MYC, ERBB4
13MP:00030129.8PTCH1, APC, SUFU, MYC, NTRK3, CTNNB1
14MP:00053879.7DMBT1, GFAP, PTCH2, PTCH1, APC, BRCA2
15MP:00053819.7DMBT1, GFAP, PTCH2, PTCH1, APC, SUFU
16MP:00053849.6DMBT1, GFAP, PTCH1, APC, BRCA2, MYC
17MP:00053859.6GFAP, PTCH2, PTCH1, APC, SUFU, MYC
18MP:00053789.6BRCA2, SUFU, APC, PTCH1, GFAP, MYC
19MP:00053889.6PTCH1, NTRK3, ERBB3, ERBB4, CTNNB1, OTX2
20MP:00028739.6H2AFY, APC, PTCH1, PTCH2, GFAP, SUFU
21MP:00053769.5DMBT1, GFAP, APC, SUFU, BRCA2, MYC
22MP:00107689.4SUFU, H2AFY, APC, PTCH1, GFAP, DMBT1
23MP:00053869.4SRRM4, MYC, BRCA2, APC, PTCH1, GFAP
24MP:00036319.1OTX2, GFAP, PTCH2, PTCH1, APC, SUFU

Publications for Medulloblastoma

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53PubMed
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Articles related to Medulloblastoma:

(show top 50)    (show all 1238)
idTitleAuthorsYear
1
Quality of Survival and Growth in Children and Young Adults in the PNET4 European Controlled Trial of Hyperfractionated Versus Conventional Radiation Therapy for Standard-Risk Medulloblastoma. (24239386)
2014
2
Multiplex meta-analysis of medulloblastoma expression studies with external controls. (24297537)
2014
3
Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma. (24280485)
2013
4
Time perception in children treated for a cerebellar medulloblastoma. (23063729)
2013
5
Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma. (23013267)
2013
6
Three down and one to go: modeling medulloblastoma subgroups. (22340583)
2012
7
Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells. (21685941)
2012
8
Genetic alterations in microRNAs in medulloblastomas. (21793975)
2012
9
Characterization of ectonucleotidases in human medulloblastoma cell lines: ecto-5'NT/CD73 in metastasis as potential prognostic factor. (23094051)
2012
10
Cerebrospinal fluid shunting and hearing loss in patients treated for medulloblastoma. (22462709)
2012
11
A tale of two tumors: pediatric and adult medulloblastoma. (23330354)
2012
12
Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a Children's Oncology Group Phase I/II study. (22665539)
2012
13
VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells. (21885916)
2011
14
Myogenic and melanotic differentiated medulloblastoma: case report. (21845588)
2011
15
Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients. (21918172)
2011
16
MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma. (21931765)
2011
17
Appraisal of the current staging system for residual medulloblastoma by volumetric analysis. (21814819)
2011
18
Medulloblastoma and gliomatosis cerebri: rare brain tumors in multiple sclerosis patients. (21234776)
2011
19
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. (19270706)
2009
20
Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas. (18068533)
2008
21
Activation of PPARalpha inhibits IGF-I-mediated growth and survival responses in medulloblastoma cell lines. (18546270)
2008
22
Correlative analyses of notch signaling with resveratrol-induced differentiation and apoptosis of human medulloblastoma cells. (18456406)
2008
23
Two new patients with Curry-Jones syndrome with trichoblastoma and medulloblastoma suggest an etiologic role of the sonic hedgehog-patched-GLI pathway. (18798318)
2008
24
Differential prefrontal-like deficit in children after cerebellar astrocytoma and medulloblastoma tumor. (18412947)
2008
25
Implication of active Erk in the classic type of human medulloblastoma. (18587705)
2008
26
Rectal adenocarcinoma following cranio-spinal radiotherapy for cerebellar medulloblastoma. (17103217)
2007
27
Hedgehog signaling promotes medulloblastoma survival via Bc/II. (17200206)
2007
28
Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis. (17452456)
2007
29
Multifocal desmoplastic medulloblastoma in an african-american child with nevoid basal cell carcinoma (gorlin) syndrome. Case report. (17328283)
2006
30
Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16. (15767543)
2005
31
E, N-cadherins and beta-catenin expression in medulloblastoma and atypical teratoid/rhabdoid tumor. (15508347)
2004
32
Diffusion-weighted MR imaging and pathologic findings in adult cerebellar medulloblastoma. (15356452)
2004
33
Effects of radiation treatment planning and patient fixation on the results of postoperative radiotherapy of childhood medulloblastoma. (14652675)
2003
34
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. (12872164)
2003
35
MDM2 overexpression is associated with short survival in adults with medulloblastoma. (11916503)
2002
36
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. (11212243)
2001
37
Evolution of malignant cerebellar astrocytoma at the site of a treated medulloblastoma: report of two cases. (11534690)
2001
38
Intense p53 staining is a valuable prognostic indicator for poor prognosis in medulloblastoma/central nervous system primitive neuroectodermal tumors. (11451203)
2001
39
Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas. (9973222)
1999
40
Expression of leukemia-inhibitory factor as an autocrinal growth factor in human medulloblastomas. (10480339)
1999
41
Expression of platelet-derived growth factor transcripts in medulloblastomas and ependymomas. (8841077)
1996
42
Tumor suppressor genes and medulloblastoma. (8817421)
1996
43
Prognostic factors in adult medulloblastoma. A clinico-pathologic study. (8804450)
1995
44
Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines. (17180032)
1995
45
Immunocytochemical demonstration of interphotoreceptor retinoid-binding protein in cerebellar medulloblastoma. (1377856)
1992
46
Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes. (1756496)
1991
47
Establishment and characterization of human medulloblastoma xenograft line. (1864766)
1991
48
Medulloblastoma cells constitutively produce granulocyte colony-stimulating factor. (1697636)
1990
49
Cerebellar medulloblastoma: the importance of posterior fossa dose to survival and patterns of failure. (6818190)
1982
50
Unilateral papilloedema in cerebellar medulloblastoma. (756436)
1978

Variations for Medulloblastoma

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Medulloblastoma:

65
id Symbol AA change Variation ID SNP ID
1APCp.Ala1296ValVAR_017653
2APCp.Val1472IleVAR_017654
3APCp.Ser1495GlyVAR_017655
4CTNNB1p.Ser33PheVAR_017617
5CTNNB1p.Ser37AlaVAR_017624

Clinvar genetic disease variations for Medulloblastoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1CTNNB1NM_001904.3(CTNNB1): c.98C> T (p.Ser33Phe)single nucleotide variantPathogenicrs121913400GRCh37Chr 3, 41266101: 41266101
2SUFUNM_016169.3(SUFU): c.44C> T (p.Pro15Leu)single nucleotide variantPathogenicrs28942088GRCh37Chr 10, 104263953: 104263953
3PTCH2NM_001166292.1(PTCH2): c.1172_1173delCT (p.Ser391Terfs)deletionPathogenicrs56126236GRCh37Chr 1, 45295116: 45295117
4BRCA2NM_000059.3(BRCA2): c.658_659delGT (p.Val220Ilefs)deletionPathogenic, risk factorrs80359604GRCh37Chr 13, 32903606: 32903607
5BRCA2NM_000059.3(BRCA2): c.5645C> G (p.Ser1882Ter)single nucleotide variantPathogenic, risk factorrs80358785GRCh37Chr 13, 32914137: 32914137

Expression for genes affiliated with Medulloblastoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Medulloblastoma

Search GEO for disease gene expression data for Medulloblastoma.

Pathways for genes affiliated with Medulloblastoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 61Thomson Reuters, 54QIAGEN, 62Tocris Bioscience, 58SinoBiological, 52PharmGKB, 5Cell Signaling Technology, 55R&D Systems
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Pathways related to Medulloblastoma according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PTCH2, PTCH1
2
Show member pathways
10.3OTX2, MYC
310.2CTNNB1, MYC, BRCA2
4
Show member pathways
Signal transduction PTEN pathway61
10.2MYC, APC, CTNNB1
510.2CTNNB1, MYC, APC
610.2CTNNB1, MYC, APC
710.2MYC, CTNNB1, APC
810.2APC, CTNNB1, MYC
9
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
10.2APC, CTNNB1, MYC
1010.2APC, MYC, CTNNB1
11
Show member pathways
10.2PTCH1, SUFU, PTCH2
12
Show member pathways
10.2CTNNB1, NTRK3, APC
1310.2APC, CTNNB1, NTRK3
1410.2ERBB3, ERBB4, CTNNB1
15
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
10.2ERBB4, ERBB3, MYC
1610.1APC, CTNNB1, BRCA2, MYC
1710.1NTRK3, ERBB3, ERBB4
18
Show member pathways
Signaling Pathways in Glioblastoma39
10.1MYC, ERBB3, BRCA2, CTNNB1
1910.1MYC, ZIC1, CTNNB1, GFAP
20
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
10.1MYC, ERBB4, CTNNB1, ERBB3
2110.1OTX2, NTRK3, GFAP, SAG
22
Show member pathways
10.1CTNNB1, ERBB3, NTRK3, ERBB4
23
Show member pathways
10.1PTCH1, PTCH2, SUFU, CTNNB1, APC
2410.0ERBB3, ERBB4, MYC, NTRK3
25
Show member pathways
10.0APC, NTRK3, ERBB3, ERBB4, CTNNB1
2610.0ERBB3, MYC, ERBB4, PTCH1, CTNNB1
27
Show member pathways
10.0NTRK3, ERBB4, ERBB3, MYC, BRCA2
2810.0PTCH2, PTCH1, CTNNB1, SUFU, APC, OTX2
29
Show member pathways
9.9NTRK3, SUFU, ERBB4, ERBB3, CTNNB1, PTCH2
309.9MYC, CTNNB1, PTCH1, BRCA2, SUFU, APC
31
Show member pathways
9.6ERBB4, ERBB3, NTRK3, MYC, SUFU, APC
32
Show member pathways
9.5CTNNB1, GFAP, PTCH2, PTCH1, APC, MYC

Compounds for genes affiliated with Medulloblastoma

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Sources:
46Novoseek, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB, 12DrugBank, 25HMDB, 3BitterDB
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Compounds related to Medulloblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1methylazoxymethanol acetate4610.7APC, CTNNB1
21-hydroxyanthraquinone4610.7APC, CTNNB1
3samp4610.7CTNNB1, APC
4neuregulin-23010.7ERBB3, ERBB4
5neuregulin-13010.6ERBB3, ERBB4
6cyclopamine46 6211.6CTNNB1, MYC, PTCH1
71,2-dimethylhydrazine4610.6APC, CTNNB1
8jnj 28871063 hydrochloride6210.6ERBB3, ERBB4
9hrgbeta14610.6MYC, ERBB3, ERBB4
10ag 4906210.6ERBB3, ERBB4
11ag 1478 hydrochloride6210.6ERBB3, ERBB4
12iressa6210.6ERBB3, ERBB4
13pertuzumab46 52 1212.6ERBB3, ERBB4
14cetuximab46 52 1212.5CTNNB1, ERBB4, ERBB3
15azoxymethane4610.5APC, CTNNB1
16o-tyrosine4610.5NTRK3, ERBB3
17trastuzumab46 52 1212.5CTNNB1, ERBB4, ERBB3
18guanine46 25 1212.4APC, SAG, SSTR2, CTNNB1
194-hydroxytamoxifen4610.4CTNNB1, MYC, BRCA2
20glutamine4610.4GFAP, APC, BRCA2, SAG, CTNNB1
21nmda46 3011.4GFAP, APC, NTRK3, ERBB4, CTNNB1
22agar4610.4GFAP, MYC, ERBB3, ERBB4, CTNNB1
23matrigel4610.4GFAP, BRCA2, NTRK3, CTNNB1
24phosphoinositide4610.4APC, SAG, ERBB3, ERBB4, CTNNB1
25thymidine46 2511.4GFAP, BRCA2, MYC, SSTR2, CTNNB1
26gefitinib46 52 1212.3CTNNB1, ERBB4, ERBB3
27cycloheximide4610.3GFAP, APC, BRCA2, MYC, NTRK3, CTNNB1
28genistein46 30 62 3 25 1215.3GFAP, BRCA2, MYC, ERBB3, ERBB4, CTNNB1
29oligonucleotide4610.3APC, BRCA2, MYC, ERBB3, CTNNB1, OTX2
30tamoxifen46 52 30 1213.3BRCA2, MYC, SSTR2, ERBB3, ERBB4, CTNNB1
31phosphotyrosine4610.3SSTR2, ERBB3, ERBB4, CTNNB1
32testosterone46 62 25 1213.3GFAP, APC, BRCA2, NTRK3, ERBB3, CTNNB1
332-amino-3-methylimidazo(4,5-f)quinoline4610.3CTNNB1, APC
34dopamine46 30 25 1213.3GFAP, APC, SAG, SSTR2, ERBB4, CTNNB1
35cisplatin46 52 62 1213.3GFAP, BRCA2, MYC, ERBB4, KLC1, CTNNB1
36linoleic acid30 46 2512.3APC, ERBB3, CTNNB1
37paclitaxel46 52 1212.3GFAP, BRCA2, MYC, CTNNB1
38phosphatidylinositol4610.2APC, BRCA2, MYC, NTRK3, ERBB3, ERBB4
39retinoic acid46 2511.2GFAP, APC, BRCA2, MYC, NTRK3, CTNNB1
40progesterone46 30 62 25 1214.2GFAP, APC, BRCA2, SSTR2, ERBB3, ERBB4
41rapamycin4610.2CTNNB1, ERBB3, MYC, APC
42threonine4610.2GFAP, APC, MYC, SAG, NTRK3, ERBB3
43p0024610.2CTNNB1, ERBB3, BRCA2
44vegf4610.2GFAP, MYC, SSTR2, NTRK3, ERBB3, ERBB4
45estrogen4610.1GFAP, APC, BRCA2, MYC, SSTR2, ERBB3
46paraffin4610.1CTNNB1, GFAP, PTCH1, APC, BRCA2, MYC
47serine4610.0DMBT1, GFAP, APC, MYC, SAG, ERBB3
48glycogen46 2511.0GFAP, APC, MYC, CTNNB1
49alpha-amanitin4610.0MYC, GFAP
50tyrosine469.9GFAP, PTCH1, APC, MYC, SAG, SSTR2

GO Terms for genes affiliated with Medulloblastoma

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17Gene Ontology
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Cellular components related to Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.4CTNNB1, APC
2lateral plasma membraneGO:01632810.4CTNNB1, ERBB3, APC
3axonal growth coneGO:04429510.3PTCH1, APC
4primary ciliumGO:07237210.3SUFU, PTCH1
5receptor complexGO:04323510.0ERBB4, ERBB3, NTRK3
6basolateral plasma membraneGO:0163239.9CTNNB1, ERBB4, ERBB3
7cytoplasmGO:0057379.7DMBT1, GFAP, APC, SUFU, BRCA2, SSTR2

Biological processes related to Medulloblastoma according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:04433610.6CTNNB1, APC
2negative regulation of cell divisionGO:05178210.5PTCH1, MYC
3regulation of smoothened signaling pathwayGO:00858910.5OTX2, ZIC1, PTCH1
4negative regulation of smoothened signaling pathwayGO:04587910.5PTCH2, PTCH1, SUFU
5positive regulation of epithelial cell differentiationGO:03085810.5APC, DMBT1
6dorsal/ventral pattern formationGO:00995310.5OTX2, APC, PTCH1
7branching involved in ureteric bud morphogenesisGO:00165810.5PTCH1, MYC, CTNNB1
8inner cell mass cell proliferationGO:00183310.4BRCA2, DMBT1
9mammary gland epithelial cell differentiationGO:06064410.4ERBB4, PTCH1
10canonical Wnt signaling pathwayGO:06007010.4APC, MYC, CTNNB1
11cell fate specificationGO:00170810.4CTNNB1, OTX2
12transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.4NTRK3, ERBB3, ERBB4
13positive regulation of transcription, DNA-templatedGO:04589310.2BRCA2, MYC, ZIC1, ERBB4, CTNNB1, OTX2
14brain developmentGO:00742010.2ZIC1, BRCA2, PTCH1
15chromosome organizationGO:05127610.2APC, MYC
16negative regulation of cell proliferationGO:00828510.1CTNNB1, ERBB4, SSTR2, APC
17proximal/distal pattern formationGO:00995410.0CTNNB1, APC

Molecular functions related to Medulloblastoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1hedgehog family protein bindingGO:09710810.4PTCH2, PTCH1
2smoothened bindingGO:00511910.4PTCH2, PTCH1
3cadherin bindingGO:04529610.3CTNNB1, APC
4hedgehog receptor activityGO:00815810.3PTCH1, PTCH2
5protein complex bindingGO:03240310.1PTCH1, MYC, CTNNB1
6repressing transcription factor bindingGO:07049110.0CTNNB1, MYC
7protein bindingGO:0055159.3OTX2, DMBT1, PTCH1, APC, H2AFY, SUFU

Products for genes affiliated with Medulloblastoma

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Sources for Medulloblastoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet