MDB
MCID: MDL005
MIFTS: 80

Medulloblastoma (MDB) malady

Genetic diseases, Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Medulloblastoma

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Disease Ontology:8 An infratentorial cancer that is located in the lower part of the brain and is a type of primitive neuroectodermal tumor.

MalaCards based summary: Medulloblastoma, also known as medulloblastoma with extensive nodularity, is related to childhood medulloblastoma and nevoid basal cell carcinoma syndrome, and has symptoms including An important gene associated with Medulloblastoma is PTCH2 (patched 2), and among its related pathways are Signaling events mediated by the Hedgehog family and TP53 network. The drug carmustine and the compounds methylazoxymethanol acetate and 1-hydroxyanthraquinone have been mentioned in the context of this disorder. Affiliated tissues include the lower part of the brain, brain and cerebellum, and related mouse phenotypes are pigmentation and hearing/vestibular/ear.

Wikipedia:65 Medulloblastoma is a highly malignant primary brain tumor (cancer) that originates in the part of the... more...

Description from OMIM:46 155255

Aliases & Classifications for Medulloblastoma

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Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt, 63UMLS via Orphanet, 35MESH via Orphanet
See all sources

Medulloblastoma, Aliases & Descriptions:

Name: Medulloblastoma 8 9 42 22 46 10 44 48 62
Medulloblastoma with Extensive Nodularity 48 62
Localized Primitive Neuroectodermal Tumor 8 62
Classic Medulloblastoma 48 62
Infratentorial Primitive Neuroectodermal Tumor 8
Desmoplastic Nodular Medulloblastoma 62
 
Desmoplastic/nodular Medulloblastoma 48
Neuroectodermal Tumor, Primitive 62
Cerebellar Neuroblastoma 48
Cns Pnet 8
Cpnet 8
Mdb 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
classic medulloblastoma:
Age of onset: Childhood
desmoplastic/nodular medulloblastoma:
Inheritance: Sporadic; Age of onset: Adulthood
medulloblastoma with extensive nodularity:
Inheritance: Sporadic; Age of onset: Neonatal/infancy; Age of death: Normal
medulloblastoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:0050902
NCIt39 C3222, C5398
OMIM46 155255
UMLS via Orphanet63 C0751291, C0025149
MESH via Orphanet35 D008527

Related Diseases for Medulloblastoma

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Diseases in the Medulloblastoma family:

Adult Medulloblastoma Medulloblastoma, Sufu-Related

Diseases related to Medulloblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1childhood medulloblastoma32.1ERBB3, ERBB4, MYC
2nevoid basal cell carcinoma syndrome31.5PTCH2, PTCH1, SUFU
3basal cell carcinoma31.4CTNNB1, SUFU, PTCH1
4glioblastoma31.3MYC, GFAP, ERBB3, DMBT1, PTCH1
5turcot syndrome31.1APC, CTNNB1
6meningioma31.0GFAP, PTCH1
7medulloblastoma, desmoplastic30.9PTCH1, NTRK3, GFAP
8glioblastoma multiforme30.7GFAP, DMBT1, ERBB3
9pineoblastoma30.7GFAP, SAG
10malignant glioma30.6ERBB4, ERBB3, GFAP, DMBT1, NTRK3
11adenoma30.5APC, MYC, SAG, CTNNB1
12retinoblastoma30.4BRCA2, MYC, GFAP, APC, SAG
13brain cancer30.4APC, NTRK3, PTCH1, GFAP, DMBT1, ERBB4
14adenocarcinoma30.1DMBT1, MYC, ERBB4, NTRK3, PTCH1, BRCA2
15breast cancer29.9ERBB3, CTNNB1, ERBB4, DMBT1, PTCH1, APC
16cerebellar medulloblastoma10.9
17adult medulloblastoma10.7
18neuroectodermal tumor10.7
19neuronitis10.6
20gardner syndrome10.6CTNNB1, APC
21basal cell carcinoma, somatic10.5PTCH1, PTCH2
22astrocytoma10.5
23intestinal neoplasm10.5APC, CTNNB1
24juvenile polyposis syndrome10.5APC
25hepatocellular adenoma10.5CTNNB1, APC
26desmoid tumor10.5APC, CTNNB1
27papillary thyroid carcinoma10.5PTCH1, APC, CTNNB1
28pineocytoma10.5GFAP, SAG
29familial adenomatous polyposis10.5CTNNB1, MYC, APC, PTCH1
30colorectal cancer, somatic10.5APC, CTNNB1
31large cell medulloblastoma10.4
32rhabdoid tumor10.4
33transitional cell carcinoma10.4ERBB3, PTCH1, ERBB4
34stomach cancer10.4ERBB3, APC, MYC, CTNNB1
35gastric adenocarcinoma10.4CTNNB1, MYC, APC
36prostate cancer10.4CTNNB1, ERBB4, MYC, ERBB3
37colorectal cancer10.4CTNNB1, APC, MYC, ERBB4, ERBB3
38atypical teratoid rhabdoid tumor10.4
39supratentorial primitive neuroectodermal tumor10.4
40ependymoma10.4
41non-small cell lung carcinoma10.4MYC, ERBB4, ERBB3, CTNNB1, APC
42melanotic medulloblastoma10.4
43fibromatosis10.3CTNNB1, APC
44male breast cancer10.3BRCA2, MYC
45peutz-jeghers syndrome10.3CTNNB1, BRCA2, APC
46tongue squamous cell carcinoma10.3DMBT1, CTNNB1, PTCH1, APC, MYC, ERBB3
47mutism10.3
48cerebellar astrocytoma10.3
49pancreatic cancer10.3ERBB3, CTNNB1, BRCA2
50endometrial carcinoma10.3BRCA2, ERBB3, CTNNB1, APC

Graphical network of the top 20 diseases related to Medulloblastoma:



Diseases related to medulloblastoma

Symptoms for Medulloblastoma

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Symptoms by clinical synopsis from OMIM:

155255

Clinical features from OMIM:

155255

HPO human phenotypes related to Medulloblastoma:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of metabolism/homeostasis HP:0001939
3 medulloblastoma HP:0002885

Drugs & Therapeutics for Medulloblastoma

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Drug clinical trials:

Search ClinicalTrials for Medulloblastoma

Search NIH Clinical Center for Medulloblastoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Medulloblastoma

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Genetic tests related to Medulloblastoma:

id Genetic test Affiliating Genes
1 Medulloblastoma22

Anatomical Context for Medulloblastoma

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MalaCards organs/tissues related to Medulloblastoma:

32
Brain, Cerebellum, Bone, Thyroid, Bone marrow, Breast, Pituitary, Kidney, Skin, Testes, Myeloid, Fetal brain, Spinal cord, Heart, Colon, Liver, T cells, Endothelial, Parietal lobe, Pineal

FMA organs/tissues related to Medulloblastoma:

14
The lower part of the brain

Animal Models for Medulloblastoma or affiliated genes

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MGI Mouse Phenotypes related to Medulloblastoma:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.1PTCH1, APC, SUFU, MYC, ERBB3, CTNNB1
2MP:000537710.1DMBT1, APC, MYC, SRRM4, NTRK3, CTNNB1
3MP:000537110.0CTNNB1, MYC, BRCA2, APC, PTCH1
4MP:000200610.0DMBT1, PTCH2, PTCH1, APC, SUFU, BRCA2
5MP:000538210.0PTCH1, APC, SUFU, MYC, ERBB4, CTNNB1
6MP:000539010.0PTCH1, APC, SUFU, BRCA2, MYC, ZIC1
7MP:00030129.9PTCH1, APC, SUFU, MYC, NTRK3, CTNNB1
8MP:00053799.9PTCH1, APC, BRCA2, MYC, ERBB3, ERBB4
9MP:00107719.9PTCH2, PTCH1, APC, SUFU, BRCA2, MYC
10MP:00053919.9GFAP, PTCH1, APC, SAG, NTRK3, CTNNB1
11MP:00053899.9PTCH2, PTCH1, APC, BRCA2, MYC, ERBB4
12MP:00053699.9GFAP, PTCH2, PTCH1, APC, MYC, ZIC1
13MP:00053809.8SUFU, APC, PTCH1, DMBT1, BRCA2, MYC
14MP:00053819.8DMBT1, GFAP, PTCH2, PTCH1, APC, SUFU
15MP:00053879.8DMBT1, GFAP, PTCH2, PTCH1, APC, BRCA2
16MP:00053859.7GFAP, PTCH2, PTCH1, APC, SUFU, MYC
17MP:00053849.6DMBT1, GFAP, PTCH1, APC, BRCA2, MYC
18MP:00053789.6BRCA2, SUFU, APC, PTCH1, GFAP, MYC
19MP:00028739.6GFAP, PTCH2, PTCH1, APC, H2AFY, SUFU
20MP:00053889.6OTX2, CTNNB1, ERBB4, ERBB3, NTRK3, PTCH1
21MP:00053769.6MYC, BRCA2, SUFU, APC, GFAP, DMBT1
22MP:00053869.5MYC, BRCA2, APC, PTCH1, GFAP, SRRM4
23MP:00107689.4SUFU, H2AFY, APC, PTCH1, GFAP, DMBT1
24MP:00036319.3OTX2, GFAP, PTCH2, PTCH1, APC, SUFU

Publications for Medulloblastoma

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Articles related to Medulloblastoma:

(show top 50)    (show all 1280)
idTitleAuthorsYear
1
Deep Sequencing Identifies IDH1 R132S Mutation in Adult Medulloblastoma. (24616312)
2014
2
Quality of Survival and Growth in Children and Young Adults in the PNET4 European Controlled Trial of Hyperfractionated Versus Conventional Radiation Therapy for Standard-Risk Medulloblastoma. (24239386)
2014
3
Multiplex meta-analysis of medulloblastoma expression studies with external controls. (24297537)
2014
4
Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma. (24280485)
2013
5
Time perception in children treated for a cerebellar medulloblastoma. (23063729)
2013
6
Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma. (23013267)
2013
7
Three down and one to go: modeling medulloblastoma subgroups. (22340583)
2012
8
Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells. (21685941)
2012
9
Genetic alterations in microRNAs in medulloblastomas. (21793975)
2012
10
Characterization of ectonucleotidases in human medulloblastoma cell lines: ecto-5'NT/CD73 in metastasis as potential prognostic factor. (23094051)
2012
11
Cerebrospinal fluid shunting and hearing loss in patients treated for medulloblastoma. (22462709)
2012
12
A tale of two tumors: pediatric and adult medulloblastoma. (23330354)
2012
13
Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a Children's Oncology Group Phase I/II study. (22665539)
2012
14
VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells. (21885916)
2011
15
Myogenic and melanotic differentiated medulloblastoma: case report. (21845588)
2011
16
Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients. (21918172)
2011
17
MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma. (21931765)
2011
18
Appraisal of the current staging system for residual medulloblastoma by volumetric analysis. (21814819)
2011
19
Medulloblastoma and gliomatosis cerebri: rare brain tumors in multiple sclerosis patients. (21234776)
2011
20
Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas. (18068533)
2008
21
Activation of PPARalpha inhibits IGF-I-mediated growth and survival responses in medulloblastoma cell lines. (18546270)
2008
22
Correlative analyses of notch signaling with resveratrol-induced differentiation and apoptosis of human medulloblastoma cells. (18456406)
2008
23
Two new patients with Curry-Jones syndrome with trichoblastoma and medulloblastoma suggest an etiologic role of the sonic hedgehog-patched-GLI pathway. (18798318)
2008
24
Differential prefrontal-like deficit in children after cerebellar astrocytoma and medulloblastoma tumor. (18412947)
2008
25
Implication of active Erk in the classic type of human medulloblastoma. (18587705)
2008
26
Rectal adenocarcinoma following cranio-spinal radiotherapy for cerebellar medulloblastoma. (17103217)
2007
27
Hedgehog signaling promotes medulloblastoma survival via Bc/II. (17200206)
2007
28
Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis. (17452456)
2007
29
Multifocal desmoplastic medulloblastoma in an african-american child with nevoid basal cell carcinoma (gorlin) syndrome. Case report. (17328283)
2006
30
Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16. (15767543)
2005
31
E, N-cadherins and beta-catenin expression in medulloblastoma and atypical teratoid/rhabdoid tumor. (15508347)
2004
32
Diffusion-weighted MR imaging and pathologic findings in adult cerebellar medulloblastoma. (15356452)
2004
33
Effects of radiation treatment planning and patient fixation on the results of postoperative radiotherapy of childhood medulloblastoma. (14652675)
2003
34
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. (12872164)
2003
35
MDM2 overexpression is associated with short survival in adults with medulloblastoma. (11916503)
2002
36
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. (11212243)
2001
37
Evolution of malignant cerebellar astrocytoma at the site of a treated medulloblastoma: report of two cases. (11534690)
2001
38
Intense p53 staining is a valuable prognostic indicator for poor prognosis in medulloblastoma/central nervous system primitive neuroectodermal tumors. (11451203)
2001
39
Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas. (9973222)
1999
40
Expression of leukemia-inhibitory factor as an autocrinal growth factor in human medulloblastomas. (10480339)
1999
41
Expression of platelet-derived growth factor transcripts in medulloblastomas and ependymomas. (8841077)
1996
42
Tumor suppressor genes and medulloblastoma. (8817421)
1996
43
Prognostic factors in adult medulloblastoma. A clinico-pathologic study. (8804450)
1995
44
Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines. (17180032)
1995
45
Immunocytochemical demonstration of interphotoreceptor retinoid-binding protein in cerebellar medulloblastoma. (1377856)
1992
46
Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes. (1756496)
1991
47
Establishment and characterization of human medulloblastoma xenograft line. (1864766)
1991
48
Medulloblastoma cells constitutively produce granulocyte colony-stimulating factor. (1697636)
1990
49
Cerebellar medulloblastoma: the importance of posterior fossa dose to survival and patterns of failure. (6818190)
1982
50
Unilateral papilloedema in cerebellar medulloblastoma. (756436)
1978

Variations for Medulloblastoma

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UniProtKB/Swiss-Prot genetic disease variations for Medulloblastoma:

64
id Symbol AA change Variation ID SNP ID
1APCp.Ala1296ValVAR_017653
2APCp.Val1472IleVAR_017654
3APCp.Ser1495GlyVAR_017655
4CTNNB1p.Ser33PheVAR_017617
5CTNNB1p.Ser37AlaVAR_017624

Clinvar genetic disease variations for Medulloblastoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1CTNNB1NM_001904.3(CTNNB1): c.98C> T (p.Ser33Phe)single nucleotide variantPathogenicrs121913400GRCh37Chr 3, 41266101: 41266101
2SUFUNM_016169.3(SUFU): c.44C> T (p.Pro15Leu)single nucleotide variantPathogenicrs28942088GRCh37Chr 10, 104263953: 104263953
3PTCH2NM_001166292.1(PTCH2): c.1172_1173delCT (p.Ser391Terfs)deletionPathogenicrs56126236GRCh37Chr 1, 45295116: 45295117
4BRCA2NM_000059.3(BRCA2): c.658_659delGT (p.Val220Ilefs)deletionPathogenicrs80359604GRCh37Chr 13, 32903606: 32903607
5BRCA2NM_000059.3(BRCA2): c.5645C> G (p.Ser1882Ter)single nucleotide variantPathogenicrs80358785GRCh37Chr 13, 32914137: 32914137

Expression for genes affiliated with Medulloblastoma

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Expression patterns in normal tissues for genes affiliated with Medulloblastoma

Search GEO for disease gene expression data for Medulloblastoma.

Pathways for genes affiliated with Medulloblastoma

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Pathways related to Medulloblastoma according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PTCH1, PTCH2
2
Show member pathways
10.3OTX2, MYC
3
Show member pathways
10.2SUFU, PTCH1, PTCH2
410.2CTNNB1, MYC, BRCA2
5
Show member pathways
Signal transduction PTEN pathway60
10.2APC, MYC, CTNNB1
610.2APC, MYC, CTNNB1
710.2APC, MYC, CTNNB1
810.2APC, MYC, CTNNB1
910.2CTNNB1, MYC, APC
1010.2CTNNB1, MYC, APC
11
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
10.2CTNNB1, MYC, APC
1210.2CTNNB1, NTRK3, APC
13
Show member pathways
10.2CTNNB1, NTRK3, APC
1410.2ERBB3, ERBB4, CTNNB1
15
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
10.2ERBB4, ERBB3, MYC
1610.1ERBB4, ERBB3, NTRK3
1710.1CTNNB1, MYC, BRCA2, APC
18
Show member pathways
Signaling Pathways in Glioblastoma37
10.1BRCA2, MYC, ERBB3, CTNNB1
1910.1CTNNB1, ZIC1, MYC, GFAP
20
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
10.1MYC, ERBB3, ERBB4, CTNNB1
2110.1OTX2, NTRK3, SAG, GFAP
22
Show member pathways
10.1NTRK3, ERBB3, ERBB4, CTNNB1
23
Show member pathways
10.1PTCH2, PTCH1, APC, SUFU, CTNNB1
2410.0MYC, NTRK3, ERBB3, ERBB4
25
Show member pathways
10.0APC, NTRK3, ERBB3, ERBB4, CTNNB1
2610.0PTCH1, MYC, ERBB3, ERBB4, CTNNB1
27
Show member pathways
10.0BRCA2, MYC, NTRK3, ERBB3, ERBB4
2810.0OTX2, CTNNB1, SUFU, APC, PTCH1, PTCH2
29
Show member pathways
9.9PTCH2, SUFU, NTRK3, ERBB3, ERBB4, CTNNB1
309.9PTCH2, PTCH1, APC, SUFU, BRCA2, MYC
31
Show member pathways
9.6GFAP, PTCH2, APC, SUFU, MYC, NTRK3
32
Show member pathways
9.6GFAP, PTCH2, PTCH1, APC, MYC, SAG

Compounds for genes affiliated with Medulloblastoma

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Compounds related to Medulloblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1methylazoxymethanol acetate4410.7APC, CTNNB1
21-hydroxyanthraquinone4410.7APC, CTNNB1
3samp4410.7APC, CTNNB1
4neuregulin-22810.7ERBB3, ERBB4
5neuregulin-12810.7ERBB3, ERBB4
61,2-dimethylhydrazine4410.6CTNNB1, APC
7cyclopamine44 6111.6MYC, CTNNB1, PTCH1
8jnj 28871063 hydrochloride6110.6ERBB4, ERBB3
9iressa6110.6ERBB4, ERBB3
10hrgbeta14410.6ERBB4, MYC, ERBB3
11ag 1478 hydrochloride6110.6ERBB4, ERBB3
12ag 4906110.6ERBB4, ERBB3
13pertuzumab44 50 1112.6ERBB3, ERBB4
14azoxymethane4410.6CTNNB1, APC
15cetuximab44 50 1112.6ERBB3, ERBB4, CTNNB1
16o-tyrosine4410.5NTRK3, ERBB3
174-hydroxytamoxifen4410.5BRCA2, CTNNB1, MYC
18trastuzumab44 50 1112.5ERBB3, ERBB4, CTNNB1
192-amino-3-methylimidazo(4,5-f)quinoline4410.5APC, CTNNB1
20tamoxifen44 50 28 1113.4ERBB4, BRCA2, ERBB3, MYC, CTNNB1
21gefitinib44 50 1112.4ERBB4, ERBB3, CTNNB1
22matrigel4410.4NTRK3, CTNNB1, BRCA2, GFAP
23glutamine4410.4GFAP, APC, BRCA2, SAG, CTNNB1
24agar4410.4ERBB3, ERBB4, GFAP, CTNNB1, MYC
25nmda44 2811.4CTNNB1, ERBB4, NTRK3, APC, GFAP
26linoleic acid28 44 2412.4ERBB3, APC, CTNNB1
27phosphoinositide4410.4CTNNB1, ERBB3, ERBB4, SAG, APC
28dopamine44 28 24 1113.4CTNNB1, ERBB4, SAG, GFAP, APC
29cycloheximide4410.3BRCA2, GFAP, MYC, NTRK3, APC, CTNNB1
30alpha-amanitin4410.3GFAP, MYC
31paclitaxel44 50 1112.3BRCA2, CTNNB1, GFAP, MYC
32genistein44 28 61 2 24 1115.3ERBB4, GFAP, MYC, CTNNB1, ERBB3, BRCA2
33oligonucleotide4410.3CTNNB1, OTX2, APC, ERBB3, MYC, BRCA2
34testosterone44 61 24 1113.3ERBB3, CTNNB1, NTRK3, BRCA2, APC, GFAP
35progesterone44 28 61 24 1114.3BRCA2, GFAP, APC, ERBB3, ERBB4, CTNNB1
36rapamycin4410.3CTNNB1, APC, MYC, ERBB3
37cisplatin44 50 61 1113.3KLC1, ERBB4, BRCA2, GFAP, CTNNB1, MYC
38retinoic acid44 2411.2APC, GFAP, BRCA2, MYC, NTRK3, CTNNB1
39phosphatidylinositol4410.2APC, BRCA2, NTRK3, ERBB3, ERBB4, MYC
40vegf4410.2CTNNB1, GFAP, ERBB3, MYC, ERBB4, NTRK3
41estrogen4410.2CTNNB1, ERBB4, ERBB3, MYC, BRCA2, APC
42threonine4410.2ERBB3, SAG, MYC, APC, CTNNB1, NTRK3
43adriamycin4410.2BRCA2, MYC, CTNNB1
44glycogen44 2411.2GFAP, APC, MYC, CTNNB1
45p0024410.2BRCA2, ERBB3, CTNNB1
46paraffin4410.2MYC, PTCH1, APC, BRCA2, SAG, ERBB3
47verapamil44 28 50 24 1114.1CTNNB1, GFAP, MYC
48serine4410.1CTNNB1, ERBB3, SAG, MYC, APC, GFAP
49exisulind4410.0APC, CTNNB1
50tyrosine4410.0GFAP, CTNNB1, ERBB4, ERBB3, NTRK3, SAG

GO Terms for genes affiliated with Medulloblastoma

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Cellular components related to Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.5CTNNB1, APC
2axonal growth coneGO:04429510.4APC, PTCH1
3lateral plasma membraneGO:01632810.4CTNNB1, ERBB3, APC
4primary ciliumGO:07237210.3SUFU, PTCH1
5receptor complexGO:04323510.2NTRK3, ERBB3, ERBB4
6basolateral plasma membraneGO:01632310.1ERBB3, ERBB4, CTNNB1
7nucleusGO:0056349.5APC, SUFU, BRCA2, MYC, PRDM13, SRRM4
8cytoplasmGO:0057379.4DMBT1, GFAP, APC, SUFU, BRCA2, NTRK3

Biological processes related to Medulloblastoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:04433610.5APC, CTNNB1
2negative regulation of cell divisionGO:05178210.5PTCH1, MYC
3negative regulation of smoothened signaling pathwayGO:04587910.5PTCH2, PTCH1, SUFU
4regulation of smoothened signaling pathwayGO:00858910.5OTX2, ZIC1, PTCH1
5positive regulation of epithelial cell differentiationGO:03085810.5APC, DMBT1
6dorsal/ventral pattern formationGO:00995310.5OTX2, APC, PTCH1
7branching involved in ureteric bud morphogenesisGO:00165810.5PTCH1, MYC, CTNNB1
8mammary gland epithelial cell differentiationGO:06064410.4ERBB4, PTCH1
9inner cell mass cell proliferationGO:00183310.4DMBT1, BRCA2
10canonical Wnt signaling pathwayGO:06007010.4APC, MYC, CTNNB1
11transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.3ERBB4, ERBB3, NTRK3
12cell fate specificationGO:00170810.3OTX2, CTNNB1
13positive regulation of transcription, DNA-templatedGO:04589310.2BRCA2, MYC, ZIC1, ERBB4, CTNNB1, OTX2
14brain developmentGO:00742010.2ZIC1, BRCA2, PTCH1
15chromosome organizationGO:05127610.2MYC, APC
16proximal/distal pattern formationGO:00995410.0APC, CTNNB1

Molecular functions related to Medulloblastoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1smoothened bindingGO:00511910.5PTCH1, PTCH2
2hedgehog family protein bindingGO:09710810.4PTCH1, PTCH2
3cadherin bindingGO:04529610.3CTNNB1, APC
4hedgehog receptor activityGO:00815810.3PTCH2, PTCH1
5protein complex bindingGO:03240310.1CTNNB1, MYC, PTCH1
6repressing transcription factor bindingGO:07049110.0CTNNB1, MYC
7protein bindingGO:0055159.3SUFU, H2AFY, APC, PTCH1, DMBT1, BRCA2

Products for genes affiliated with Medulloblastoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Medulloblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet