Medulloblastoma malady

Wikipedia: Medulloblastoma is a highly malignant primary brain tumor that originates in the cerebellum or posterior...⁴⁴ more...

MalaCards: Medulloblastoma, also known as medulloblastoma nos (morphologic abnormality), is related to neuronitis and carcinoma. An important gene associated with Medulloblastoma is NTRK3 (neurotrophic tyrosine kinase, receptor, type 3), and among its related pathways are Wnt / Hedgehog / Notch and CREB Pathway. The drug carmustine and the compounds dopamine and guanine have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and heart, and related mouse phenotypes are reproductive system and hematopoietic system.

OMIM: 155255

Aliases & Descriptions:

medulloblastoma 6 7 30 33 8 32 43 medulloblastoma nos (morphologic abnormality) 6 medulloblastoma (morphologic abnormality) 6

medulloblastomas 6 mdb 30

Diseases related to medulloblastoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 766)

id	Related Disease	Score	Top Affiliating Genes
1	neuronitis	40.3	PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLC1, KLF4
2	carcinoma	38.9	PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLF4, NCAM1
3	neuroectodermal tumors	37.5	NCAM1, KIT, RB1, SERPINF1, VIM, VIP
4	large cell medulloblastoma	35.8	MYC, RAB11FIP3, RAB18, SAG, JKAMP, MET
5	childhood medulloblastoma	35.8	MYC, MYCN, MGMT, ERBB3, ERBB4
6	cerebellar medulloblastoma	34.3	PCNA, BTRC, RBP3, CHRND, SAG, AXIN1
7	astrocytoma	33.9	PIK3CA, PIK3R1, PIK3CG, NCAM1, KIT, PCNA
8	neuroblastoma	33.7	PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLF4, NCAM1
9	rhabdomyosarcoma	33.7	NCAM1, KIR2DS4, PCNA, RB1, NBN, VIM
10	glioblastoma	33.5	PIK3CA, PIK3CG, RB1, MYCN, RAC1, BIRC5
11	adult medulloblastoma	33.2	MTIF2, MDM2, FAM83H, TP53, TNFSF10
12	supratentorial primitive neuroectodermal tumor	33.1	MYC, MYCN, MYB, RASSF1, S100B, TP53
13	ependymoma	32.5	NCAM1, RB1, VIM, RASSF1, BIRC5, PAX5
14	rhabdoid tumors	32.3	VIM, MUC1, IGF1R, IGF2, PTPRC, SMARCB1
15	atypical teratoid rhabdoid tumor	32.2	VIM, RASSF1, MUC1, CDH2, INA, CCND1
16	basal cell carcinoma	32.0	BCL2, JUP, CD44, ITGB1, MMP12, FOXM1
17	leukemia	31.4	PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLF4, NCAM1
18	cerebellar liponeurocytoma	31.0	APC, TP53, PTCH1, CTNNB1, GFAP, SYP
19	nevus	30.9	PIK3CA, KIT, PCNA, VIM, MYB, BCL2
20	breast carcinoma	30.7	PIK3CA, PIK3R1, PIK3CG, KIT, SFRP1, PCGF2
21	pilocytic astrocytoma	30.6	KDR, S100A4, S100A6, S100B, CDKN1A, CDKN2A
22	retinoblastoma	30.6	PIK3CD, PIK3CA, PIK3R1, PIK3CG, NCAM1, KIT
23	herpes simplex	30.6	PIK3CA, PIK3CG, REST, PCNA, VIM, MYC
24	meningioma	29.9	PIK3CG, NCAM1, SFRP1, PCNA, RB1, NBN
25	nevoid basal cell carcinoma syndrome	29.7	PCNA, GSTM1, GLI1, HPSE, TP53, PTCH1
26	wilms tumor	29.6	NCAM1, KIR2DS4, PCNA, BTRC, SET, SERPINF1
27	craniopharyngioma	29.4	PCNA, VIM, S100A6, INS, MAP2, IGF1R
28	retinitis	29.3	PIK3CA, PIK3CG, KIT, SFRP1, SFRP2, PCNA
29	anaplastic oligodendroglioma	29.3	PIK3CA, RB1, KDR, CDKN2C, CDKN2B, CDKN2A
30	thyroiditis	29.0	PIK3CA, PIK3R1, PIK3CG, KLF4, NCAM1, KIT
31	nijmegen breakage syndrome	28.6	NBN, RAD51, LIG4, ATM, CDKN1A, MDM2
32	oligodendroglioma	28.6	CDKN2C, CDKN2B, CDKN2A, MGMT, TP73, PTEN
33	lissencephaly	28.6	SERPINF1, PAFAH1B1, YWHAE, MNT, RPH3AL, ABR
34	blastoma	28.4	RB1, VIM, MYCN, BIRC5, BCL2, MMP9
35	hypoxia	28.1	PIK3CD, PIK3CA, PIK3R1, PIK3CG, KIT, SFRP1
36	adenomatous polyposis coli	28.0	PIK3CG, KLF4, BTRC, MYC, BIRC5, BCL2
37	encephalitis	27.9	PIK3CG, PAWR, BCL2, BCL2L1, S100B, JUN
38	dna topoisomerase ii	27.4	PCNA, MYC, BCL2L1, JUN, CDKN1A, CCNB1
39	cholera	27.2	VIP, PARP1, MOAP1, CDKN2A, FOS, INS
40	polyposis	27.1	PIK3CG, KLF4, SFRP1, PCNA, BTRC, RB1
41	malignant glioma	26.8	PIK3CA, PIK3CG, KIT, SFRP1, SFRP2, PCNA
42	melanoma	17.1	PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLC1, NCAM1
43	prostatitis	17.1	PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLF4, NCAM1
44	pancreatitis	16.6	PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLC1, KLF4
45	adenocarcinoma	16.3	PIK3CA, PIK3R1, PIK3CG, KLF4, NCAM1, KIT
46	sarcoma	16.3	PIK3CD, PIK3CA, PIK3R1, PIK3CG, NCAM1, KIT
47	ganglioglioma	15.8	MYCN, BIRC5, BCL2L1, S100B, GRIN1, ENO2
48	burkitt's lymphoma	15.7	MYC, MYCN, MYB, BMI1, RASSF1, BIRC5
49	adrenocortical tumor	15.7	MYC, AXIN2, AURKA, CDKN2A, CDK4, MDM2
50	osteosarcoma	15.6	PIK3CA, PIK3CG, KIT, PCNA, RB1, RBL1

Clinical features from OMIM: 155255

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine

MalaCards organs/tissues related to medulloblastoma:

²²

MGI Mouse Phenotypes related to medulloblastoma:

²⁵ (show all 30)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	reproductive system phenotype	MP:0005389	13.7	PIK3CA, KLF4, SFRP2, BTRC, RBL1, NBN
2	hematopoietic system phenotype	MP:0005397	13.6	KIT, SFRP1, PCGF2, PCNA, BTRC, RBL1
3	growth/size phenotype	MP:0005378	13.5	PIK3CA, PIK3R1, PIK3CG, KLC1, REST, KIT
4	normal phenotype	MP:0002873	13.3	PIK3R1, KLF4, SFRP2, RBL1, VIP, VCAN
5	behavior/neurological phenotype	MP:0005386	13.1	PIK3CA, KLC1, KLF4, NCAM1, KIT, RB1
6	craniofacial phenotype	MP:0005382	12.9	KLF4, KIT, PCGF2, RBL1, NBN, MYCN
7	endocrine/exocrine gland phenotype	MP:0005379	12.5	KLF4, SFRP2, RBL1, NBN, VIPR1, PAFAH1B1
8	skeleton phenotype	MP:0005390	11.6	PIK3CD, PIK3CG, KIT, SFRP1, BTG2, RB1
9	pigmentation phenotype	MP:0001186	11.1	KIT, RB1, SERPINF1, MYC, BMP7, RAC1
10	no phenotypic analysis	MP:0003012	11.1	PIK3CD, PIK3R1, REST, SFRP1, SFRP2, PCNA
11	hearing/vestibular/ear phenotype	MP:0005377	10.7	KIT, RB1, MYC, BMP2, BMP7, PAX5
12	taste/olfaction phenotype	MP:0005394	10.6	PAX6, ENO2, MAPT, MAPK1, CASP3, CASP9
13	vision/eye phenotype	MP:0005391	10.3	PIK3CA, NCAM1, REST, KIT, PCGF2, RB1
14	other phenotype	MP:0005395	9.6	KLC1, KDR, AXIN1, CDKN2A, ITGB1, MAPT
15	adipose tissue phenotype	MP:0005375	8.4	PIK3CA, PIK3R1, SFRP1, RB1, RBL1, VIPR2
16	renal/urinary system phenotype	MP:0005367	INF	KIT, MYCN, BMP7, PAX3, PAX6, BCL2
17	integument phenotype	MP:0010771	INF	PIK3CG, KLF4, KIT, RB1, RBL1, MYC
18	cardiovascular system phenotype	MP:0005385	INF	PIK3CD, PIK3CA, PIK3R1, PIK3CG, KIT, SFRP1
19	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLF4, KIT
20	cellular phenotype	MP:0005384	INF	PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLC1, KLF4
21	immune system phenotype	MP:0005387	INF	PIK3CD, KIT, SFRP1, PCGF2, BTRC, RBL1
22	respiratory system phenotype	MP:0005388	INF	MYCN, RAI1, LIF, PAX3, PAX6, KCNK9
23	liver/biliary system phenotype	MP:0005370	INF	KIT, RBL1, MYCN, MYB, LIG4, LIF
24	tumorigenesis	MP:0002006	INF	PIK3CA, PIK3R1, KLF4, KIT, BTRC, RB1
25	limbs/digits/tail phenotype	MP:0005371	INF	KIT, SFRP1, SFRP2, PCGF2, RB1, RBL1
26	muscle phenotype	MP:0005369	INF	PIK3CA, PIK3R1, PIK3CG, KIT, SFRP2, RB1
27	nervous system phenotype	MP:0003631	INF	KLC1, REST, KIT, SFRP1, SFRP2, PCGF2
28	embryogenesis phenotype	MP:0005380	INF	PIK3CA, REST, KIT, SFRP1, SFRP2, PCGF2
29	mortality/aging	MP:0010768	INF	PIK3CA, KLF4, NCAM1, REST, SFRP1, SFRP2
30	digestive/alimentary phenotype	MP:0005381	INF	KLF4, KIT, PCGF2, RB1, RBL1, SERPINF1

Articles related to medulloblastoma:

(show top 50)    (show all 458)

id	Title	Authors	Year	Affiliating Genes
1	Heterogeneity of familial medulloblastoma and contrib ution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma. (21188540)	Slade I.... Rahman N.	2011	PTCH1, SUFU
2	c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patien ts. (21324178)	von Bueren A.O.... Grotzer M.A.	2011	MYC
3	siRNA-mediated downregulation of MMP-9 and uPAR in co mbination with radiation induces G2/M cell-cycle arrest in Medulloblastoma. (21148633)	Nagaraju G.P.... Rao J.S.	2011	MMP9, PLAUR
4	KIT expression and methylation in medulloblastoma and PNET cell lines and tumors. (20853134)	Enguita-GermA!n M.... Castresana J.S.	2011	KIT
5	Disabling c-Myc in childhood medulloblastoma and atyp ical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD. (20053783)	Shalaby T.... Grotzer M.	2010	MYC
6	Regulation of sonic hedgehog-GLI1 downstream target g enes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma. (21059263)	Shahi M.H.... Castresana J.S.	2010	SHH, CCND2, JUP
7	Amplification and overexpression of KIT, PDGFRA, and VEGFR2 in medulloblastomas and primitive neuroectodermal tumors. (19779861)	Blom T.... Nupponen N.N.	2010	KDR, PDGFRA, KIT
8	OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas. (20028867)	Adamson D.C.... Yan H.	2010	OTX2
9	Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines. (20162618)	Caracciolo V.... Katsetos C.D.	2010	TUBG1, TUBB3
10	Notch signaling is not essential in sonic hedgehog-ac tivated medulloblastoma. (20440271)	Hatton B.A.... Olson J.M.	2010	SHH
11	Amplification and overexpression of Hsa-miR-30b, Hsa- miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma. (19584924)	Lu Y.... Clifford S.C.	2009	KHDRBS3
12	Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. (19164512)	Frappart P.O.... McKinnon P.J.	2009	TP53, LIG4, CCND2
13	YAP1 is amplified and up-regulated in hedgehog-associ ated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proli feration. (19952108)	Fernandez-L A.... Kenney A.M.	2009	SHH, YAP1
14	Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics. (19197950)	Fattet S.... Delattre O.	2009	CTNNB1
15	Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells. (18592012)	Yu L.J.... Liu J.	2008	BCL2, CCND1, STAT3
16	Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas. (18172656)	Schuller U.... Grasbon-Frodl E.	2008	AKT1
17	The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma. (18058815)	Pfister S.... Lichter P.	2008	KAT8
18	Differential expression and prognostic significance of SOX genes in pediatric medulloblastoma and ependymoma identified by microarray analysis. (18577562)	de Bont J.M.... Pieters R.	2008	SOX9, SOX4
19	Episomal amplification of MYCN in a case of medulloblastoma. (18286303)	Surace C.... Storlazzi C.T.	2008	MYCN, MYCNOS
20	Differential expression of Notch1 and Notch2 in astrocytoma and medulloblastoma (19035115)	Xu P.... Wang G.X.	2008	NOTCH1, NOTCH2
21	Overlay analysis of the oligonucleotide array gene expression profiles and copy number abnormalities as determined by array comparative genomic hybridization in medulloblastomas. (17044047)	Lo K.C.... Cowell J.K.	2007	DDX1
22	All-trans-retinoic acid induces cell growth arrest in a human medulloblastoma cell line. (17453147)	Chang Q.... Gu J.	2007	MYC
23	Human parathyroid hormone-related protein and human parathyroid hormone receptor type 1 are expressed in human medulloblastomas and regulate cell proliferation and apoptosis in medulloblastoma-derived cell lines. (17372745)	Gessi M.... Ranelletti F.O.	2007	PTH1R
24	Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3. (17371797)	Farioli-Vecchioli S.... Tirone F.	2007	BTG2
25	Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY. (16368187)	Azizi A.A.... Lubec G.	2006	OVCA2
26	c-Myc downregulation: a critical molecular event in resveratrol-induced cell cycle arrest and apoptosis of human medulloblastoma cells. (16724266)	Zhang P.... Liu J.	2006	MYC
27	Radiation-induced cerebellar glioblastoma at the site of a treated medulloblastoma: case report. (15926395)	Yang S.Y.... Kim S.K.	2005	TP53, SYP
28	Differentiation of classic medulloblastoma into metastatic large cell medulloblastoma with focal rhabdoid differentiation in the absence of posterior fossa recurrence. (15759130)	Donner L.R.	2005	DES
29	PTEN and DMBT1 homozygous deletion and expression in medulloblastomas and supratentorial primitive neuroectodermal tumors. (15547761)	Inda M.M.... Castresana J.S.	2004	PTEN, DMBT1
30	Differential patterns of insulin-like growth factor-I and -II mRNA expression in medulloblastoma. (15488026)	Van Doorn J.... van Buul-Offers S.C.	2004	IGF2
31	On the neuronal/neuroblastic nature of medulloblastomas: a tribute to Pio del Rio Hortega and Moises Polak. (12471454)	Katsetos C.D.... MAPrk S.J.	2003	NTRK3
32	Transcriptional profiling of medulloblastoma in children. (12959442)	Park P.C.... Rutka J.T.	2003	FGFR2, ODC1, CCND2
33	Medulloblastoma displays distinct regional matrix metalloprotease expression. (11716074)	Vince G.H.... Tonn J.C.	2001	MMP9, MMP12
34	Expression of the neurotrophin receptor p75NTR in medulloblastomas is correlated with distinct histological and clinical features: evidence for a medulloblastoma subtype derived from the external granule cell layer. (10744061)	BA1hren J.... Pietsch T.	2000	NGFR
35	Expression of leukemia-inhibitory factor as an autocrinal growth factor in human medulloblastomas. (10480339)	Liu J.... Li H.	1999	IL6R, IL6ST, LIF
36	Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)1-nitrosourea. (10589786)	Kokkinakis D.M.... Schold S.C.	1999	MGMT
37	Activity of fotemustine in medulloblastoma and malignant glioma xenografts in relation to O6-alkylguanine-DNA alkyltransferase and alkylpurine-DNA N-glycosylase activity. (9516937)	Vassal G.... Gouyette A.	1998	PPAT
38	Polysialylated NCAM in CSF, a marker for invasive medulloblastoma (9759372)	Dubois C.... Rampini C.	1998	NCAM1
39	Interferon yield and MHC antigen expression of human medulloblastoma cells and its suppression during dibutyryl cyclic AMP-induced differentiation: do medulloblastoma cells derive from bipotent neuronal and glial progenitors? (9777250)	Park K.C.... Hayakawa T.	1998	IFNB1
40	Animal model of human medulloblastoma: clinical, magnetic resonance imaging, and histopathological findings after intra-cisternal injection of MHH-MED-1 cells into nude rats. (9180909)	Schabet M.... Pietsch T.	1997	GFAP
41	Altered neural cell fates and medulloblastoma in mouse patched mutants. (9262482)	Goodrich L.V.... Scott M.P.	1997	PTCH1
42	Functional analysis of trk proto-oncogene product in medulloblastoma cells. (9420431)	Kokunai T.... Tamaki N.	1996	NGF
43	Variable imprinting of H19 and IGF2 in fetal cerebellum and medulloblastoma. (8957451)	Albrecht S.... Pietsch T.	1996	IGF2, H19
44	New approach for the treatment of medulloblastoma by transfection with glial fibrillary acidic protein gene. (8853241)	Sadatomo T.... Sugita K.	1996	GFAP
45	Deregulated expression of PAX5 in medulloblastoma. (7777574)	Kozmik Z.... Aguzzi A.	1995	PAX6, PAX5, EN2
46	Calbindin-D28k in subsets of medulloblastomas and in the human medulloblastoma cell line D283 Med. (7646332)	Katsetos C.D.... Urich H.	1995	CALB1
47	Transthyretin expression in medulloblastomas and medulloblastoma cell lines. (8632835)	Albrecht S.... Pietsch T.	1995	TTR
48	Physical mapping of chromosome 17p13.3 in the region of a putative tumor suppressor gene important in medulloblastoma. (7829075)	McDonald J.D.... Cogen P.H.	1994	ABR
49	Nerve growth factor receptor expression in medulloblastomas and the potential role of nerve growth factor as a differentiating agent in medulloblastoma cell lines. (8437665)	Keles G.E.... Bothwell M.	1993	NGFR, NGF
50	An embryonic origin for medulloblastoma. (2065021)	Valtz N.L.... McKay R.D.	1991	NES

Genes related to medulloblastoma according to GeneCards:

(show top 50)    (show all 377)

id	Symbol	Description	Score	GeneCards Section Context
1	NTRK3	neurotrophic tyrosine kinase, receptor, type 3	11.1	Summaries, Publications
2	SUFU	suppressor of fused homolog (Drosophila)	11.0	Summaries, Publications
3	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications, Summaries
4	ZIC1	Zic family member 1	11.0	Summaries, Publications, Expressions, Functions
5	OTX2	orthodenticle homeobox 2	11.0	Summaries, Publications
6	DMBT1	deleted in malignant brain tumors 1	11.0	Publications, Summaries
7	JKAMP	JNK1/MAPK8-associated membrane protein	11.0	Publications, Aliases & Descriptions
8	SRRM4	serine/arginine repetitive matrix 4	11.0	Aliases & Descriptions, Publications
9	PTCH2	patched 2	11.0	Summaries, Functions, Publications
10	H2AFY	H2A histone family, member Y	11.0	Publications, Aliases & Descriptions
11	KLC1	kinesin light chain 1	11.0	Publications, Aliases & Descriptions
12	PTCH1	patched 1	11.0	Publications
13	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
14	GFAP	glial fibrillary acidic protein	11.0	Publications
15	SAG	S-antigen; retina and pineal gland (arrestin)	11.0	Publications
16	ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	11.0	Publications
17	ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	11.0	Publications
18	PRDM13	PR domain containing 13	11.0	Publications
19	RAB18	RAB18, member RAS oncogene family	11.0	Publications
20	SYP	synaptophysin	11.0	Publications
21	CROCC	ciliary rootlet coiled-coil, rootletin	11.0	Publications
22	NGFR	nerve growth factor receptor	11.0	Publications
23	MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	11.0	Publications
24	AXIN1	axin 1	11.0	Publications
25	SSTR2	somatostatin receptor 2	11.0	Publications
26	RAB11FIP3	RAB11 family interacting protein 3 (class II)	11.0	Publications
27	FAM184A	family with sequence similarity 184, member A	11.0
28	DES	desmin	11.0	Publications
29	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
30	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	11.0	Publications
31	APC	adenomatous polyposis coli	11.0	Publications
32	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
33	CASP9	caspase 9, apoptosis-related cysteine peptidase	11.0	Publications
34	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
35	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
36	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	11.0	Publications
37	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.0	Publications
38	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0	Publications
39	TP53	tumor protein p53	11.0	Publications
40	HIC1	hypermethylated in cancer 1	11.0	Publications
41	NRBP2	nuclear receptor binding protein 2	11.0
42	CHRND	cholinergic receptor, nicotinic, delta (muscle)	11.0	Publications
43	GLI1	GLI family zinc finger 1	11.0	Publications
44	NEUROG1	neurogenin 1	11.0	Publications
45	BAP1	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	11.0	Publications
46	CACNG8	calcium channel, voltage-dependent, gamma subunit 8	11.0
47	OR4C12	olfactory receptor, family 4, subfamily C, member 12	11.0
48	SYNM	synemin, intermediate filament protein	11.0	Publications
49	RBP3	retinol binding protein 3, interstitial	11.0	Publications
50	MTIF2	mitochondrial translational initiation factor 2	11.0	Publications

Pathways related to medulloblastoma according to GeneDecks:

(show top 50)    (show all 407)

id	Pathway	Score	Top Affiliating Genes
1	Wnt / Hedgehog / Notch3	12.2	KLF4, SFRP1, NANOG, BMI1, BMP7, PAX5
2	CREB Pathway36	12.0	PIK3R1, KIT, VEGFB, BMP2, BMP7, KDR
3	14-3-3 Induced Intracellular Signaling36	12.0	PIK3R1, VEGFB, BMP2, BMP7, LIFR, YWHAE
4	PAK Pathway36	11.6	PIK3R1, KIT, VEGFB, BMP2, BMP7, RAC1
5	Nanog in Mammalian ESC Pluripotency36	11.5	KIT, NANOG, VEGFB, BMP2, BMP7, LIFR
6	JAK-STAT Pathway36	11.4	PIK3R1, KIT, VEGFB, MYC, BMP2, BMP7
7	Apoptosis20	11.4	PIK3CD, PIK3CA, PIK3R1, PIK3CG, BCL2, BCL2L1
8	ERK5 Signaling36	11.4	KIT, VEGFB, MYC, BMP2, BMP7, KDR
9	Development_Neurotrophin family signaling41	11.4	PIK3CD, PIK3CA, PIK3R1, RAC1, JUN, MAP2K2
10	Tec Kinases Signaling36	11.4	PIK3R1, VEGFB, BMP2, BMP7, RAC1, LIFR
11	Mitochondrial Apoptosis36	11.3	PIK3R1, KIT, VEGFB, BMP2, BMP7, KDR
12	Epithelial Adherens Junctions36	11.2	VEGFB, BMP2, BMP7, RAC1, JUP, CDH2
13	Glioma Invasiveness36	11.2	VEGFB, BMP2, BMP7, CD44, ITGA9, ITGAV
14	STAT3 Pathway36	11.2	MYC, BMP2, BMP7, RAC1, LIF, LIFR
15	p53 signaling pathway20	11.1	ATM, CDK6, CDKN1A, CDKN2A, CDK4, MDM2
16	Apoptosis and survival Role of CDK5 in neuronal death and survival10	11.1	BCL2, CASP9, AKT3, ERBB3, NTRK1, NGF
17	Development_Ligand-independent activation of ESR1 and ESR241	11.0	PIK3CD, PIK3CA, PIK3R1, IRS1, MAP2K2, MAPK3
18	Telomerase Components in Cell Signaling36	11.0	KIT, RB1, VEGFB, MYC, BMP2, BMP7
19	TRKA Signaling36	11.0	PIK3R1, MYC, RAC1, JUN, MAP2K2, MAPK3
20	PTEN Pathway36	11.0	PIK3R1, KIT, VEGFB, BMP2, BMP7, RAC1
21	Nuclear Receptor Activation by Vitamin-A36	10.9	KIT, VEGFB, BMP2, BMP7, KDR, FGF6
22	DHA Signaling36	10.9	PIK3R1, KIT, SERPINF1, VEGFB, BMP2, BMP7
23	Development Prolactin receptor signaling10	10.9	PIK3CD, PIK3CA, PIK3R1, MYC, RAC1, BCL2
24	Pancreatic Adenocarcinoma36	10.9	PIK3R1, KIT, RB1, VEGFB, BMP2, BMP7
25	Germ Cell-Sertoli Cell Junction Dynamics36	10.8	RAC1, PAK1, AXIN1, JUP, CDH2, ITGB1
26	Signal transduction AKT signaling10	10.8	PIK3CD, PIK3R1, IRS1, GSK3B
27	GPCR Pathway36	10.7	PIK3R1, KIT, VEGFB, BMP2, BMP7, RAC1
28	Development VEGF-family signaling10	10.7	PIK3CD, PIK3CA, PIK3R1, VEGFB, KDR, ITGAV
29	PPAR Pathway36	10.7	PIK3R1, KIT, VEGFB, BMP2, ITGA9, ITGAV
30	Rho Family GTPases36	10.6	PIK3R1, KIT, VIM, VEGFB, BMP2, BMP7
31	Non-small cell lung cancer20	10.6	PIK3CD, PIK3CA, PIK3R1, PIK3CG, RB1, RASSF1
32	p53 Signaling36	10.5	BCL2, ATM, CDKN1A, CDK4, FOS, MDM2
33	Small cell lung cancer20	10.5	PIK3CD, PIK3CA, PIK3R1, PIK3CG, RB1, MYC
34	Development_HGF signaling pathway41	10.4	PIK3CD, PIK3CA, PIK3R1, RAC1, JUN, CDH1
35	Phospholipase-C Pathway36	10.4	KIT, VEGFB, BMP2, BMP7, RAC1, KDR
36	Paxillin Interactions36	10.3	PIK3R1, KIT, VEGFB, BMP2, RAC1, LIFR
37	Glioblastoma Multiforme36	10.3	PIK3R1, RB1, RAC1, AXIN1, CDK6, CDKN1A
38	MAPK Family Pathway36	10.2	PIK3R1, VEGFB, BMP2, BMP7, RAC1, PAK1
39	Development Thrombopoietin-regulated cell processes10	10.2	PIK3CD, PIK3CA, PIK3R1, MYC, RAC1, BIRC5
40	Development_Thrombopoietin-regulated cell processes41	10.2	PIK3CD, PIK3CA, PIK3R1, MYC, RAC1, BIRC5
41	eIF2 Pathway36	10.2	PIK3R1, KIT, BMP7, INS, GSK3B, FGF6
42	TGF-Beta Pathway36	10.2	PIK3R1, VEGFB, BMP2, BMP7, KDR, BCL2
43	G1-S Phase Transition36	10.1	RB1, ATM, CDK6, CDKN1A, CDKN2C, CDKN2B
44	Development Ligand-independent activation of ESR1 and ESR210	10.1	PIK3CA, PIK3R1, IRS1, MAP2K2, MAPK1, MAP2K1
45	Colorectal Cancer Metastasis36	10.0	PIK3R1, MYC, BIRC5, BCL2L1, AXIN2, CDKN1A
46	mTOR Pathway36	10.0	PIK3R1, VEGFB, BMP2, BMP7, RAC1, IRS1
47	Focal adhesion20	9.9	PIK3CD, PIK3CA, PIK3R1, PIK3CG, VEGFB, RAC1
48	CDC42 Pathway36	9.9	KIT, LIFR, PAK1, KDR, JUN, CDH1
49	ErbB signaling pathway20	9.5	PIK3CD, PIK3CA, PIK3R1, PIK3CG, MYC, PAK1
50	EGF Pathway36	9.5	PIK3R1, MYC, RAC1, PAK1, MUC1, JUN

Compounds related to medulloblastoma according to GeneDecks:

(show top 50)    (show all 412)

id	Compound	Score	Top Affiliating Genes
1	dopamine32 9 18 9	15.4	PIK3CA, NCAM1, VIP, MYCN, BMP2, LIF
2	guanine32 9 18 9	15.3	VIP, MYB, RAD51, RAC1, BIRC5, SAG
3	glycogen32 18	13.2	PIK3CA, PIK3R1, PIK3CG, KIT, SFRP1, BTRC
4	alanine32	12.0	NCAM1, PCNA, RBL1, VIP, VIPR1, MYC
5	superoxide32 18	12.8	PIK3CA, PIK3R1, RB1, RAC1, LIF, BIRC5
6	leucine32	11.8	PIK3CA, PIK3R1, KIT, RB1, RBL1, RBP3
7	adenylate32	11.7	PIK3CA, PIK3CG, VIM, VIP, VIPR1, VIPR2
8	o6-methylguanine32	11.5	PCNA, RAD51, RASSF1, CDKN2B, CDKN2A, CDH1
9	gaba32 42	12.4	NCAM1, VIM, VIP, S100B, GSR, GRIA1
10	cholesterol32 9 18 9	14.4	PIK3CA, PIK3R1, RB1, BMP2, RAC1, LIF
11	glutamine32	11.3	PIK3CG, NCAM1, KIT, PCNA, RBP3, VIM
12	ceramide32	11.2	PIK3CA, PIK3R1, RB1, PAWR, BCL2L1, UGCG
13	melphalan32 9 9	13.2	RAD51, BIRC5, BCL2L1, MGMT, MAPK3, CCNB1
14	p00232	11.1	KIT, RB1, BIRC5, JUP, CD44, CDH1
15	phenylalanine32	11.1	PIK3R1, SCG5, ASCL1, TUBB, PNMT, TTR
16	norepinephrine32 9 18 9	14.0	VIP, LIF, S100A6, S100B, MMP9, INS
17	creatinine32	10.8	NCAM1, PCNA, BMP2, BMP7, MUC1, S100B
18	oxygen32 18	11.8	RB1, SERPINF1, VEGFB, MYB, BMP2, RAC1
19	sulindac32 9 9	12.8	PCNA, BIRC5, BCL2, BCL2L1, CDKN1A, CDH1
20	thalidomide32 42 9 9	13.7	BIRC5, KDR, BCL2L1, CD36, FGFR2, IL6R
21	12-o-tetradecanoylphorbol 13-acetate32	10.7	NCAM1, RB1, MYC, LIF, CDKN1A, CDKN1B
22	n acetylcysteine32	10.6	PCNA, BIRC5, KDR, ATM, CDKN1A, CDKN1B
23	ascorbic acid32 18	11.5	PIK3CG, PCNA, BMP2, BMP7, RAC1, LIF
24	valine32	10.5	KIT, VIM, VIP, RAC1, BCAT1, S100B
25	fludarabine32 9 9	12.4	BIRC5, PARP1, BCL2, BCL2L1, CDKN1B, CDK4
26	matrigel32	10.4	PIK3CA, PIK3R1, PIK3CG, NCAM1, RB1, SERPINF1
27	lovastatin32 42 9 9	13.3	RB1, RBL1, BMP2, RAC1, CDK6, CDKN1A
28	nocodazole32 42 9 9	13.2	VIM, RAC1, BIRC5, CDKN1A, CDH1, GTDC2
29	hyaluronic acid32 18	11.2	VIM, VCAN, MYC, RAC1, MUC1, CD36
30	carboplatin32 34 9 9	13.1	RB1, LIF, PARP1, KDR, BCL2, CDK4
31	mitomycin c32	10.0	PCNA, RB1, NBN, RAD51, BIRC5, ATM
32	lactate32	10.0	PIK3CA, NCAM1, KIT, PCNA, VIM, VIP
33	noxa32	9.9	BIRC5, BCL2, BCL2L1, CDKN1A, MDM2, FAS
34	cd 43732	9.8	MYC, PARP1, BCL2, BCL2L1, JUN, CDKN1A
35	rottlerin32 42	10.8	PIK3R1, PIK3CG, RAC1, PARP1, JUN, CDK6
36	oxaliplatin32 34 9 9	12.7	BIRC5, BCL2L1, CDKN1A, MGMT, GSTM1, GSTT1
37	5fluorouracil32	9.6	PIK3CA, PIK3CG, KIT, PCNA, RB1, RBL1
38	cytarabine32 34 9 9	12.6	KIT, PCNA, RB1, VIM, MYC, LIF
39	celecoxib32 42 34 9 18 9	14.5	PIK3R1, PIK3CG, PCNA, BIRC5, PARP1, KDR
40	sulforaphane32	9.4	PIK3CG, RB1, PARP1, JUN, CDKN1A, MGMT
41	sb 20358032 42	10.3	RB1, VIM, BMP2, RAC1, LIF, BIRC5
42	actinomycin d32	9.3	PIK3CA, PIK3CG, KIT, RB1, VIM, VIPR1
43	ciglitazone32	9.3	PARP1, BCL2L1, JUN, CDKN1A, CDKN1B, MMP9
44	calcitriol32 42 9 18 9	13.2	RB1, MYC, BMP2, BMP7, LIF, PAX5
45	herbimycin a32 42	10.0	PIK3CG, MYC, JUN, CDK6, CD36, CDK4
46	cysteine32	INF	KIR2DS4, PCNA, SERPINF1, MYB, RAC1, LIF
47	agar32	INF	PIK3CA, PIK3R1, RB1, VIM, MYCN, RASSF1
48	arginine32	INF	PIK3CA, REST, RBL1, VIP, MYCNOS, MYB
49	lysine32	INF	SET, MYB, KCNK9, KCNK3, SAG, S100A6
50	atp32	INF	PIK3CA, NCAM1, KIT, RB1, RBL1, RAD51

Cellular components related to medulloblastoma according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	INF	TUBB3, SSTR2, SPINT2, CTNNB1, CTNNBIP1, NRBP2
2	nucleolus	GO:005730	12.6	TP53, TNR, TERT, SUFU, DDX1, ERBB4
3	cytosol	GO:005829	12.1	PIK3CG, XRCC4, S100A6, AXIN1, AURKA, JUN
4	integral to plasma membrane	GO:005887	11.3	PLAUR, NTRK3, NTRK2, NTRK1, SSTR2, PTPRC
5	Axin-APC-beta-catenin-GSK3B complex	GO:034747	10.9	CTNNBIP1, CTNNB1, APC, GSK3B, AXIN2, AXIN1
6	perinuclear region of cytoplasm	GO:048471	10.9	HRAS, HMGB2, ERBB2, PTCH1, CTNNB1, SNCG
7	neuronal cell body	GO:043025	10.8	SORT1, S100B, ASCL1, GSK3B, MET, GRIA1
8	nucleoplasm	GO:005654	10.7	MAPK1, NOTCH2, NGFR, WT1, EGR1, HIF1A
9	extracellular region	GO:005576	10.5	NTF3, SNCA, PLAUR, NOTCH1, NOTCH2, SPINT2
10	growth cone	GO:030426	10.3	SNCA, TSC1, DPYSL3, CXCR4, NTRK2, OTX2
11	extracellular space	GO:005615	10.2	SHH, PDGFC, PDGFA, NGF, COL1A2, SST
12	protein complex	GO:043234	10.1	MDM2, MMP9, CDKN2A, PAK1, BMP2, MYC
13	plasma membrane	GO:005886	10.1	PTGER1, PTH1R, PTGER3, PTEN, PTCH1, PTGER4
14	cell surface	GO:009986	9.2	NCAM1, SFRP1, PDGFA, PDGFB, SHH, ABCB1
15	nucleus	GO:005634	INF	IRS1, MAGEA1, MAPK3, MAPK14, MAPK1, MAP2K1

Biological processes related to medulloblastoma according to GeneDecks:

(show top 50)    (show all 121)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of protein phosphorylation	GO:001934	12.0	BMP2, AXIN1, AXIN2, FAM129A, MAPK3, CCND2
2	negative regulation of cell proliferation	GO:008285	11.9	KLF4, REST, SFRP1, SFRP2, BTG2, BMP2
3	apoptotic process	GO:006915	11.6	NBN, VIM, RAC1, BIRC5, PAWR, PAK1
4	phosphatidylinositol-mediated signaling	GO:048015	11.6	PIK3CA, PIK3R1, PCNA, AURKA, CDKN1B, FOXO1
5	response to wounding	GO:009611	11.6	RAC1, PAX6, MET, CASP3, TNC, SMO
6	positive regulation of cell proliferation	GO:008284	11.5	KIT, SFRP1, SFRP2, NBN, VIP, VIPR1
7	positive regulation of ERK1 and ERK2 cascade	GO:070374	11.4	VEGFB, BMP2, KDR, CD44, FGFR2, MAPK3
8	negative regulation of canonical Wnt receptor signaling pathway	GO:090090	11.3	SFRP1, SFRP2, AXIN2, FRZB, CDH2, GSK3B
9	cell cycle arrest	GO:007050	11.2	RB1, NBN, MYC, RASSF1, ATM, CDK6
10	cell proliferation	GO:008283	11.2	PCNA, NBN, SERPINF1, NANOG, LIG4, BCAT1
11	response to DNA damage stimulus	GO:006974	11.2	BTG2, MYC, RASSF1, BCL2, YAP1, ATM
12	heart development	GO:007507	11.1	PCNA, VCAN, BMP2, ATM, MEF2A, MAP2K5
13	nerve growth factor receptor signaling pathway	GO:048011	11.1	PIK3CA, PIK3R1, RAC1, YWHAE, CDKN1B, FOXO1
14	negative regulation of neuron differentiation	GO:045665	11.1	REST, NBN, BMP7, PAX6, ITGB1, ASCL1
15	positive regulation of cell division	GO:051781	11.0	VEGFB, FGF6, FGFR2, APC, IGF2, PDGFA
16	virus-host interaction	GO:019048	10.9	PIK3R1, BTRC, RB1, RBL1, VIM, KDR
17	negative regulation of smoothened signaling pathway	GO:045879	10.9	BTRC, RB1, KCTD11, GLI3, PTCH1, PTCH2
18	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.9	MYC, MOAP1, CDKN1B, CDKN2A, FASLG, FAS
19	epithelial to mesenchymal transition	GO:001837	10.9	BMP2, BMP7, S100A4, GSK3B, CTNNB1, NOTCH1
20	response to estradiol stimulus	GO:032355	10.9	AURKA, MMP9, ENO2, CCND2, F3, CASP8
21	positive regulation of epithelial cell proliferation	GO:050679	10.8	SFRP1, MYC, FGFR2, MAP2K5, CCND2, HRAS
22	fibroblast growth factor receptor signaling pathway	GO:008543	10.8	PIK3CA, PIK3R1, CDKN1B, FOXO1, GSK3B, FGF6
23	positive regulation of peptidyl-serine phosphorylation	GO:033138	10.8	PIK3CA, SFRP2, LIF, PAK1, BCL2, AXIN1
24	protein autophosphorylation	GO:046777	10.8	KIT, PAK1, KDR, AURKA, ATM, FGFR2
25	positive regulation of neuroblast proliferation	GO:002052	10.8	PAX6, ASPM, GLI3, CTNNB1, NOTCH1, SHH
26	signal transduction	GO:007165	10.7	PIK3CD, KIT, BTRC, VIPR2, CHRND, S100A6
27	negative regulation of epithelial cell proliferation	GO:050680	10.7	SFRP1, SFRP2, RB1, PAX6, CDK6, CDKN2B
28	regulation of gene expression	GO:010468	10.7	NANOG, BMI1, CDK6, CDK4, IRS1, NGFR
29	positive regulation of MAPK cascade	GO:043410	10.7	KIT, LIF, KDR, CD36, CDH2, ITGB1
30	anti-apoptosis	GO:006916	10.6	PIK3CA, VEGFB, BIRC5, BCL2, BCL2L1, MUC1
31	positive regulation of fibroblast proliferation	GO:048146	10.6	MYC, BMI1, LIG4, XRCC4, S100A6, JUN
32	negative regulation of neuron apoptotic process	GO:043524	10.6	SET, VEGFB, LIG4, BCL2, BCL2L1, BARHL1
33	induction of apoptosis by intracellular signals	GO:008629	10.6	MYC, BCL2, BCL2L1, CDKN1A, CASP7, CASP3
34	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.6	KIT, KDR, INS, ERBB3, NTRK2, PDGFA
35	Ras protein signal transduction	GO:007265	10.5	RB1, RASSF1, CDKN1A, CDKN2A, MAP2K2, MAPK3
36	response to organic cyclic compound	GO:014070	10.5	SFRP1, BTG2, JUN, CDKN1A, MET, ENO2
37	axon guidance	GO:007411	10.4	NCAM1, RAC1, PAK1, PAX6, ITGA9, ITGAV
38	positive regulation of neuron apoptotic process	GO:043525	10.4	ATM, JUN, ASCL1, FASLG, CASP7, CASP3
39	positive regulation of apoptotic process	GO:043065	10.4	REST, SFRP1, SFRP2, BMP2, PAWR, ATM
40	positive regulation of cell migration	GO:030335	10.3	BMP2, KDR, ITGAV, ITGB1, IRS1, INS
41	activation of MAPK activity	GO:000187	10.2	KIT, MET, GRM4, MAP2K2, MAPK3, MAPK14
42	response to drug	GO:042493	10.2	SFRP1, SFRP2, NBN, MYC, BCL2, KCNK3
43	negative regulation of apoptotic process	GO:043066	10.1	PIK3CG, SFRP1, PCGF2, BTG2, MYC, KDR
44	positive regulation of DNA replication	GO:045740	10.1	JUN, INS, MET, IGF1R, GLI1, GLI2
45	release of cytochrome c from mitochondria	GO:001836	10.0	MYC, BCL2, BCL2L1, JUN, CASP7, CASP3
46	epidermal growth factor receptor signaling pathway	GO:007173	9.8	PIK3CA, PIK3R1, CDKN1B, FOXO1, GSK3B, MDM2
47	negative regulation of transcription from RNA polymerase II promoter	GO:000122	INF	KLF4, REST, PCGF2, MYC, MYB, BMI1
48	positive regulation of transcription, DNA-dependent	GO:045893	INF	KLF4, REST, SFRP1, BTRC, RB1, MYC
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	KLF4, SFRP2, RB1, RBM14, RBL1, NANOG
50	negative regulation of transcription, DNA-dependent	GO:045892	INF	KLF4, REST, SFRP1, SFRP2, BTRC, RB1

Molecular functions related to medulloblastoma according to GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding transcription factor activity	GO:003700	12.4	HIC1, EGR1, WT1, NOTCH1, CREBZF, CREBBP
2	protein homodimerization activity	GO:042803	11.6	SLIT2, ERBB4, ERBB3, HMGCR, CADM1, ALDH9A1
3	protein kinase binding	GO:019901	11.3	CCND1, CCND2, CCNB1, MAPT, APC, TP53
4	transcription regulatory region DNA binding	GO:044212	11.1	WT1, HIF1A, AHR, THRA, TFAP2A, STAT3
5	growth factor activity	GO:008083	11.1	PDGFB, PDGFC, EGF, TGFA, TGFB2, DKK1
6	sequence-specific DNA binding	GO:043565	11.1	HIC1, EGR1, WT1, CREBZF, PPARA, OTX2
7	protein heterodimerization activity	GO:046982	11.1	TP53, OTX2, PDGFA, PDGFB, EGFR, HIF1A
8	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive	GO:001077	11.1	HIF1A, TFAP2A, SOX11, SOX4, SOX9, WT1
9	identical protein binding	GO:042802	11.1	TP73, TP53, ERBB2, AKT1, CASP8, DAZL
10	beta-catenin binding	GO:008013	11.0	SOX9, CTNNBIP1, SUFU, GLI3, APC, MET
11	transcription factor binding	GO:008134	11.0	TNFRSF10A, SUFU, CTNNB1, CREBBP, HIF1A, AHR
12	protein C-terminus binding	GO:008022	10.6	HRAS, ERBB2, ERCC4, CTNNB1, TOP2A, CADM1
13	transmembrane receptor protein tyrosine kinase activity	GO:004714	10.6	EGFR, PDGFRA, NTRK3, NTRK1, ERBB2, ERBB4
14	protein tyrosine kinase activity	GO:004713	10.5	ERBB3, ERBB4, ERBB2, PDGFRB, EGFR, IGF1R
15	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.4	CASP3, CDKN2A, CDKN1B, CDKN2B, CDKN2C, CDKN1A
16	histone deacetylase binding	GO:042826	10.1	HDAC9, HDAC3, TOP2B, TOP2A, HIF1A, HIC1
17	enzyme binding	GO:019899	9.9	PTEN, PTGS2, CTNNB1, PLAUR, NOTCH1, EGFR
18	double-stranded DNA binding	GO:003690	9.8	WT1, EGFR, EGR1, POU3F4, CTNNB1, HMGB2
19	protein binding	GO:005515	INF	DKK1, ABCB1, EGR1, EGFR, EGF, SHH
20	ATP binding	GO:005524	INF	DAPK3, DAPK1, DDX1, TBK1, TP53, ERBB2
21	chromatin binding	GO:003682	INF	TOP2A, TOP1, H2AFY, , TOP2B, TGIF1