MDB
MCID: MDL005
MIFTS: 82

Medulloblastoma (MDB) malady

Neuronal diseases, Cancer diseases categories

Summaries for Medulloblastoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Medulloblastoma is a highly malignant primary brain tumor that originates in the cerebellum or posterior... more...

MalaCards: Medulloblastoma, also known as medulloblastoma with extensive nodularity, is related to childhood medulloblastoma and astrocytoma. An important gene associated with Medulloblastoma is PTCH2 (patched 2), and among its related pathways are Rho Family GTPases and Signaling by GPCR. The drug carmustine and the compounds tyrosine and paraffin have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and bone, and related mouse phenotypes are nervous system and mortality/aging.

Description from OMIM:46 155255

Aliases & Classifications for Medulloblastoma

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Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 22GTR, 39NCIt, 56SNOMED-CT, 34MeSH, 57SNOMED-CT via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
desmoplastic/nodular medulloblastoma:
Inheritance: Sporadic; Age of onset: Neonatal/infancy
medulloblastoma with extensive nodularity:
Inheritance: Sporadic; Age of onset: Neonatal/infancy
medulloblastoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

medulloblastoma 8 9 42 46 10 44 48 60
medulloblastoma with extensive nodularity 48 60
classic medulloblastoma 48 60
medulloblastomas 8 22
desmoplastic/nodular medulloblastoma 48
cerebellar neuroblastoma 48
medulloblastoma nos 8
mdb 42


External Ids:

Disease Ontology8 DOID:3858
OMIM46 155255
NCIt39 C3222
MeSH34 D008527
SNOMED-CT via Orphanet57 32456001, 443333004, 83217000
MESH via Orphanet35 D008527
UMLS via Orphanet61 C0025149

Related Diseases for Medulloblastoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Medulloblastoma family:

Adult Medulloblastoma Medulloblastoma, Sufu-Related

Diseases related to Medulloblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1childhood medulloblastoma31.3ERBB4, ERBB3, MYC
2astrocytoma30.7DMBT1, NGFR, GFAP, ERBB3
3basal cell carcinoma30.6CTNNB1, SUFU, PTCH1
4nevoid basal cell carcinoma syndrome30.6PTCH1, PTCH2, SUFU
5meningioma30.3PTCH1, GFAP
6neuroblastoma30.2NGFR, MYC
7turcot syndrome30.2CTNNB1, APC
8medulloblastoma, desmoplastic30.1NTRK3, GFAP, PTCH1
9rhabdomyosarcoma30.1ERBB3, PTCH1
10ganglioneuroma30.0NGFR, GFAP
11adenocarcinoma30.0BRCA2, APC, CTNNB1, DMBT1, NTRK3, MYC
12brain cancer29.9APC, DMBT1, NTRK3, NGFR, GFAP, PTCH1
13retinoblastoma29.9BRCA2, SAG, APC, MYC, NGFR, GFAP
14adenoma29.9SAG, APC, CTNNB1, MYC
15malignant glioma29.9DMBT1, NGFR, GFAP
16sarcoma29.9BRCA2, ERBB3
17glioblastoma multiforme29.9ERBB3, GFAP, DMBT1
18pineoblastoma29.9SAG, GFAP
19breast cancer29.7BRCA2, CTNNB1, NTRK3, MYC, NGFR, PTCH1
20multiple sclerosis29.7SAG, NGFR, GFAP
21oligodendroglioma29.7GFAP, DMBT1
22retinitis29.7SAG
23pituitary adenoma29.7APC
24cerebellar medulloblastoma10.9
25adult medulloblastoma10.8
26primitive neuroectodermal tumor10.6
27brain medulloblastoma10.6
28neuronitis10.5
29large cell medulloblastoma10.4
30melanotic medulloblastoma10.4
31supratentorial primitive neuroectodermal tumor10.4
32atypical teratoid rhabdoid tumor10.4
33nodular medulloblastoma10.3
34mutism10.2
35cerebellar astrocytoma10.2
36leukemia10.2
37thyroiditis10.2
38syringomyelia10.1
39cerebritis10.1
40cerebellar liponeurocytoma10.1
41nijmegen breakage syndrome10.1
42adult brain medulloblastoma10.1
43cerebellar vermis medulloblastoma10.1
44encephalitis10.1
45pediatric ependymoma10.1
46gangliocytoma10.1
47cerebellar disease10.1
48ependymoblastoma10.1
49cerebral neuroblastoma10.0
50squamous cell carcinoma10.0APC, CTNNB1, DMBT1, MYC, NGFR, PTCH1

Graphical network of the top 20 diseases related to Medulloblastoma:



Diseases related to medulloblastoma

Clinical Features for Medulloblastoma

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46OMIM
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Clinical features from OMIM:

155255

Clinical synopsis from OMIM:

155255

Drugs & Therapeutics for Medulloblastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Medulloblastoma

Drug clinical trials:

Search ClinicalTrials for Medulloblastoma

Search NIH Clinical Center for Medulloblastoma

Search CenterWatch for Medulloblastoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Medulloblastoma

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22GTR
See all sources

Genetic tests related to Medulloblastoma:

id Genetic test Affiliating Genes
1 Medulloblastoma22

Anatomical Context for Medulloblastoma

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32MalaCards
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MalaCards organs/tissues related to Medulloblastoma:

32
Brain, Cerebellum, Bone, Thyroid, Breast, Bone marrow, Pituitary, Myeloid, Fetal brain, Testes, Kidney, Heart, Skin, Pineal, Colon, Liver, Endothelial, T cells, Spinal cord, Parietal lobe

Animal Models for Medulloblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Medulloblastoma:

36 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363112.9ERBB4, KLC1, ZIC1, BRCA2, SAG, APC
2MP:001076812.6NTRK3, DMBT1, CTNNB1, APC, BRCA2, ZIC1
3MP:000287312.6NGFR, MYC, NTRK3, CTNNB1, APC, BRCA2
4MP:000538612.5NTRK3, CTNNB1, APC, BRCA2, ZIC1, KLC1
5MP:000537812.4CTNNB1, APC, BRCA2, ZIC1, KLC1, NTRK3
6MP:000538112.3BRCA2, APC, CTNNB1, DMBT1, MYC, NGFR
7MP:000538512.3APC, CTNNB1, NTRK3, MYC, NGFR, GFAP
8MP:000538412.2DMBT1, CTNNB1, APC, BRCA2, KLC1, MYC
9MP:000536912.2ZIC1, APC, CTNNB1, MYC, NGFR, GFAP
10MP:000538712.0BRCA2, APC, CTNNB1, DMBT1, MYC, NGFR
11MP:000538012.0BRCA2, APC, CTNNB1, DMBT1, MYC, OTX2
12MP:000537711.8APC, CTNNB1, DMBT1, NTRK3, MYC, NGFR
13MP:001077111.7BRCA2, APC, CTNNB1, MYC, SUFU, PTCH2
14MP:000538211.7APC, CTNNB1, MYC, NGFR, OTX2, SUFU
15MP:000539111.7SAG, APC, CTNNB1, NTRK3, NGFR, GFAP
16MP:000537911.6BRCA2, APC, CTNNB1, MYC, OTX2, PTCH1
17MP:000539011.6ZIC1, BRCA2, APC, CTNNB1, MYC, OTX2
18MP:000538911.5BRCA2, APC, CTNNB1, MYC, OTX2, PTCH2
19MP:000200611.4CTNNB1, DMBT1, SUFU, PTCH2, PTCH1
20MP:000538811.3CTNNB1, NTRK3, NGFR, OTX2, ERBB3, ERBB4
21MP:000301211.2CTNNB1, NTRK3, MYC, SUFU, PTCH1, APC
22MP:000539711.2BRCA2, APC, CTNNB1, MYC, NGFR, PTCH2
23MP:000537611.1BRCA2, DMBT1, NGFR, GFAP, OTX2, SUFU
24MP:000118611.0SUFU, OTX2
25MP:000537110.7BRCA2

Publications for Medulloblastoma

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50PubMed
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Articles related to Medulloblastoma:

(show top 50)    (show all 1252)
idTitleAuthorsYear
1
Evaluation of amifostine for protection against cisplatin-induced serious hearing loss in children treated for average-risk or high-risk medulloblastoma. (24414535)
2014
2
CRX/OTX3: a useful marker in the differential diagnosis of tumors of the pineal region and indicator of photoreceptor differentiation in medulloblastomas and atypical teratoid rhabdoid tumors. (23235340)
2013
3
Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression. (24145352)
2013
4
Final height and insulin-like growth factor-1 in children with medulloblastoma treated with growth hormone. (23775040)
2013
5
Signaling pathway and molecular subgroups of medulloblastoma. (23826403)
2013
6
Overexpression of HMGA1 deregulates tumor growth via cdc25A and alters migration/invasion through a cdc25A-independent pathway in medulloblastoma. (22249617)
2012
7
Distinct patterns of human medulloblastoma dissemination in the developing chick embryo nervous system. (22322278)
2012
8
Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy. (22188814)
2012
9
Medulloblastoma: progress over time. (22498198)
2012
10
Role of Epidermal Growth Factor-Triggered PI3K/Akt Signaling in the Migration of Medulloblastoma-Derived Cells. (24273611)
2012
11
Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor. (22682621)
2012
12
Myogenic and melanotic differentiated medulloblastoma: case report. (21845588)
2011
13
Heparanase Modulates Shh and Wnt3a Signaling in Human Medulloblastoma Cells. (21442027)
2011
14
The estrogen receptor beta agonist diarylpropionitrile (DPN) inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways. (21636213)
2011
15
Combination chemotherapy with ifosfamide, cisplatin, and etoposide for medulloblastoma: single-institute experience and differences in efficacy for subgroups of medulloblastoma. (21590299)
2011
16
Reirradiation and concomitant metronomic temozolomide: an efficient combination for local control in medulloblastoma disease? (22042276)
2011
17
PRAME gene expression profile in medulloblastoma. (21359415)
2011
18
SPARC stimulates neuronal differentiation of medulloblastoma cells via the Notch1/STAT3 pathway. (21613407)
2011
19
Finding the perfect partner for medulloblastoma prognostication. (21911713)
2011
20
Metastatic spread outside the central nervous system of anaplastic medulloblastoma associated with a spinal-peritoneal shunt immediately after radiotherapy. (22213777)
2011
21
Medulloblastoma with myogenic differentiation: long-term survival in a patient treated with aggressive combination therapy and autologous stem cell transplantation. (21688181)
2011
22
Lu]-DOTA-Tyr-octreotate: A Potential Targeted Radiotherapeutic for the Treatment of Medulloblastoma. (21243098)
2010
23
Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD. (20053783)
2010
24
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. (20414201)
2010
25
Complete sequencing and oxidative modification of manganese superoxide dismutase in medulloblastoma cells. (19676086)
2009
26
The gene expression profiles of medulloblastoma cell lines resistant to preactivated cyclophosphamide. (18473730)
2008
27
Sinonasal carcinoma after irradiation for medulloblastoma in nevoid basal cell carcinoma syndrome. (17826543)
2007
28
Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity. (17361331)
2007
29
Molecular array analyses of 51 pediatric tumors shows overlap between malignant intracranial ectomesenchymoma and MPNST but not medulloblastoma or atypical teratoid rhabdoid tumor. (17431644)
2007
30
Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses. (17206475)
2007
31
Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma. (16570196)
2006
32
Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus. (15717928)
2005
33
Anaplasia is rare and does not influence prognosis in adult medulloblastoma. (16215458)
2005
34
Diffusion-weighted MR imaging and pathologic findings in adult cerebellar medulloblastoma. (15356452)
2004
35
Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival. (15126347)
2004
36
Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells. (14871995)
2004
37
Resveratrol promotes differentiation and induces Fas-independent apoptosis of human medulloblastoma cells. (14583387)
2003
38
Childhood medulloblastoma in northwest England 1954 to 1997: incidence and survival. (12729144)
2003
39
Familial medulloblastoma: case report of one family and review of the literature. (12182422)
2002
40
Neurotrophins and neuronal versus glial differentiation in medulloblastomas and other pediatric brain tumors. (9560008)
1998
41
Animal model of human medulloblastoma: clinical, magnetic resonance imaging, and histopathological findings after intra-cisternal injection of MHH-MED-1 cells into nude rats. (9180909)
1997
42
Expression of N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptor genes in neuroblastoma, medulloblastoma, and other cells lines. (8915893)
1996
43
Prognostic factors in adult medulloblastoma. A clinico-pathologic study. (8804450)
1995
44
M4 protocol for cerebellar medulloblastoma: supratentorial radiotherapy may not be avoided. (1512166)
1992
45
Voltage-gated sodium channels expressed in the human cerebellar medulloblastoma cell line TE671. (2160039)
1990
46
Seasonal variation in incidence of cerebellar medulloblastoma. (4083392)
1985
47
Congenital cerebellar medulloblastoma. (3964981)
1985
48
Cerebellar medulloblastoma in adults. (6716169)
1984
49
Cerebellar medulloblastoma. An analysis of four cases of extraneural metastasis. (717292)
1978
50
Diagnosis and management of skeletal metastases from cerebellar medulloblastoma. (1277952)
1976

Genetic Variations for Medulloblastoma

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Medulloblastoma:

62
id Symbol AA change Variation ID SNP ID
1APCp.Ala1296ValVAR_017653
2APCp.Val1472IleVAR_017654
3APCp.Ser1495GlyVAR_017655
4CTNNB1p.Ser33PheVAR_017617
5CTNNB1p.Ser37AlaVAR_017624

Expression for genes affiliated with Medulloblastoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Medulloblastoma

Search GEO for disease gene expression data for Medulloblastoma.

Pathways for genes affiliated with Medulloblastoma

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 4Cell Signaling Technology, 12EMD Millipore, 37NCBI BioSystems Database, 59Tocris Bioscience, 52R&D Systems, 55SinoBiological, 49PharmGKB
See all sources

Pathways related to Medulloblastoma according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.7APC, CTNNB1, NTRK3, MYC, NGFR, GFAP
2
Hide members
11.7SAG, APC, CTNNB1, MYC, NGFR, GFAP
311.3BRCA2, APC, CTNNB1, MYC, SUFU, PTCH2
4
Hide members
11.3CTNNB1, NTRK3, NGFR, SUFU, PTCH2, ERBB3
511.2PTCH1, APC, CTNNB1, OTX2, SUFU, PTCH2
6
Hide members
11.2APC, CTNNB1, NTRK3, MYC, NGFR, ERBB3
7
Hide members
11.2BRCA2, NTRK3, MYC, NGFR, ERBB3, ERBB4
8
Hide members
11.1APC, CTNNB1, SUFU, PTCH2, PTCH1
911.1ERBB4, ERBB3, PTCH1, MYC, CTNNB1
1011.1SAG, NTRK3, NGFR, GFAP, OTX2
11
Hide members
11.1CTNNB1, NTRK3, NGFR, ERBB3, ERBB4
12
Hide members
11.1ERBB4, ERBB3, NGFR, MYC, NTRK3
13
Hide members
11.1ERBB4, ERBB3, NGFR, MYC, NTRK3
1411.0BRCA2, APC, CTNNB1, MYC
15
Hide members
11.0APC, CTNNB1, NTRK3, ERBB4
1611.0APC, CTNNB1, NTRK3, NGFR
17
Hide members
11.0ERBB3, MYC, CTNNB1, BRCA2
1811.0ZIC1, CTNNB1, MYC, GFAP
19
Hide members
11.0ERBB4, ERBB3, MYC, CTNNB1
2011.0NTRK3, MYC, ERBB3, ERBB4
21
Hide members
10.8PTCH1, PTCH2, SUFU
2210.8APC, CTNNB1, MYC
2310.8APC, CTNNB1, MYC
2410.8MYC, CTNNB1, APC
2510.8ERBB4, ERBB3, CTNNB1
2610.8ERBB4, ERBB3, NTRK3
27
Hide members
10.8MYC, ERBB3, ERBB4
2810.8GFAP, NGFR, MYC
29
Hide members
10.7ERBB4, ERBB3

Compounds for genes affiliated with Medulloblastoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 49PharmGKB
See all sources

Compounds related to Medulloblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1tyrosine4412.1SAG, APC, CTNNB1, NTRK3, MYC, NGFR
2paraffin4412.0ERBB3, BRCA2, SAG, APC, CTNNB1, MYC
3phosphatidylinositol4411.9BRCA2, APC, CTNNB1, NTRK3, MYC, NGFR
4threonine4411.9SAG, APC, CTNNB1, NTRK3, MYC, NGFR
5serine4411.8SAG, APC, CTNNB1, DMBT1, MYC, NGFR
6progesterone44 59 28 11 2415.8BRCA2, APC, CTNNB1, NGFR, GFAP, ERBB3
7oligonucleotide4411.8BRCA2, APC, CTNNB1, MYC, NGFR, OTX2
8vegf4411.7CTNNB1, NTRK3, MYC, NGFR, GFAP, ERBB3
9retinoic acid44 2412.7BRCA2, APC, CTNNB1, NTRK3, MYC, NGFR
10agar4411.7CTNNB1, MYC, NGFR, GFAP, ERBB3, ERBB4
11nmda44 2812.7APC, CTNNB1, NTRK3, NGFR, GFAP, ERBB4
12phosphoinositide4411.6SAG, APC, CTNNB1, NGFR, ERBB3, ERBB4
13genistein44 28 59 2 11 2416.6BRCA2, CTNNB1, MYC, GFAP, ERBB3, ERBB4
14dopamine44 28 11 2414.6SAG, APC, CTNNB1, NGFR, GFAP, ERBB4
15cycloheximide4411.6BRCA2, APC, CTNNB1, NTRK3, MYC, GFAP
16testosterone44 59 11 2414.6BRCA2, APC, CTNNB1, NTRK3, GFAP, ERBB3
17matrigel4411.5BRCA2, CTNNB1, NTRK3, NGFR, GFAP
18glutamine4411.4BRCA2, SAG, APC, CTNNB1, GFAP
19cisplatin44 49 59 1114.4BRCA2, CTNNB1, MYC, GFAP, ERBB4
20thymidine44 2412.4GFAP, NGFR, MYC, CTNNB1, BRCA2
21hrgbeta14411.3MYC, ERBB3, ERBB4
22cyclopamine44 5912.3CTNNB1, MYC, PTCH1
23cetuximab44 49 1113.2CTNNB1, ERBB3, ERBB4
24polyacrylamide4411.2BRCA2, APC, NGFR, GFAP
25retinoid4411.2NGFR, MYC, CTNNB1, SAG
26tamoxifen44 49 28 1114.1ERBB4, CTNNB1
27methylazoxymethanol acetate4411.1APC, CTNNB1
281-hydroxyanthraquinone4411.1APC, CTNNB1
29neurotrophin-32811.1NTRK3, NGFR
30phosphotyrosine4411.1ERBB4, ERBB3, NGFR, CTNNB1
31neuregulin-22811.1ERBB3, ERBB4
32neuregulin-12811.1ERBB3, ERBB4
33trastuzumab44 49 1113.1ERBB4, ERBB3, CTNNB1
34samp4411.1CTNNB1, APC
35jnj 28871063 hydrochloride5911.1ERBB3, ERBB4
36ag 4905911.1ERBB3, ERBB4
37ag 1478 hydrochloride5911.1ERBB3, ERBB4
38iressa5911.0ERBB3, ERBB4
394-hydroxytamoxifen4411.0BRCA2, CTNNB1, MYC
401,2-dimethylhydrazine4411.0APC, CTNNB1
41estrogen4411.0GFAP
42pertuzumab44 49 1113.0ERBB3, ERBB4
43o-tyrosine4411.0NTRK3, ERBB3
44paclitaxel44 49 1113.0BRCA2, CTNNB1, MYC, GFAP
45acetylcholine44 49 28 11 2415.0ERBB4, ERBB3, GFAP, NGFR
46gefitinib44 49 1113.0CTNNB1, ERBB3, ERBB4
47azoxymethane4410.9CTNNB1, APC
48ethanol44 49 11 2413.9ERBB4, ERBB3, GFAP, NGFR
492-amino-3-methylimidazo(4,5-f)quinoline4410.8CTNNB1, APC
50linoleic acid44 28 2412.5APC, CTNNB1, ERBB3

GO Terms for genes affiliated with Medulloblastoma

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16Gene Ontology
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Cellular components related to Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.7CTNNB1, APC
2lateral plasma membraneGO:01632810.5ERBB3, CTNNB1, APC

Biological processes related to Medulloblastoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-dependentGO:04589311.5ZIC1, BRCA2, CTNNB1, MYC, OTX2, ERBB4
2regulation of smoothened signaling pathwayGO:00858911.1PTCH1, OTX2, ZIC1
3negative regulation of smoothened signaling pathwayGO:04587911.1PTCH1, PTCH2, SUFU
4dorsal/ventral pattern formationGO:00995311.1PTCH1, OTX2, APC
5branching involved in ureteric bud morphogenesisGO:00165811.0CTNNB1, MYC, PTCH1
6transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716911.0ERBB4, ERBB3, NTRK3
7negative regulation of cell divisionGO:05178210.9PTCH1, MYC
8canonical Wnt receptor signaling pathwayGO:06007010.9APC, CTNNB1, MYC
9positive regulation of epithelial cell differentiationGO:03085810.8DMBT1, APC
10chromosome organizationGO:05127610.7MYC, APC
11mammary gland epithelial cell differentiationGO:06064410.7ERBB4, PTCH1
12inner cell mass cell proliferationGO:00183310.6DMBT1, BRCA2
13cell fate specificationGO:00170810.4OTX2, CTNNB1

Molecular functions related to Medulloblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.8DMBT1, CTNNB1, APC, BRCA2, KLC1, MYC
2smoothened bindingGO:00511910.7PTCH1, PTCH2
3hedgehog receptor activityGO:00815810.7PTCH1, PTCH2
4hedgehog family protein bindingGO:09710810.6PTCH1, PTCH2

Products for genes affiliated with Medulloblastoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Medulloblastoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet