MCID: MDL005
MIFTS: 71

Medulloblastoma malady

Genetic diseases, Rare diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Medulloblastoma

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Sources:
46OMIM, 8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 22GTR, 61UMLS, 39NCIt, 56SNOMED-CT, 33MeSH, 62UMLS via Orphanet, 34MESH via Orphanet
See all sources

Aliases & Descriptions for Medulloblastoma:

Name: Medulloblastoma 46 8 9 42 10 44 48 22 61
Localized Primitive Neuroectodermal Tumor 8 61
Infratentorial Primitive Neuroectodermal Tumor 8
Neuroectodermal Tumor, Primitive 61
Medulloblastoma, Desmoplastic 46
 
Medulloblastoma Desmoplastic 44
Cns Pnet 8
Cpnet 8
Mdb 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
medulloblastoma:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe),1-9/1000000 (United States); Age of onset: All ages; Age of death: adolescent,adult,early childhood,infantile,late childhood,young Adult


External Ids:

OMIM46 155255
Disease Ontology8 DOID:0050902
NCIt39 C3222, C5398
Orphanet48 616
UMLS via Orphanet62 C0025149
MESH via Orphanet34 D008527

Summaries for Medulloblastoma

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OMIM:46 Medulloblastoma is the most common brain tumor in children. It accounts for 16% of all pediatric brain tumors, and 40%... (155255) more...

MalaCards based summary: Medulloblastoma, also known as localized primitive neuroectodermal tumor, is related to childhood medulloblastoma and basal cell carcinoma, and has symptoms including autosomal dominant inheritance, abnormality of metabolism/homeostasis and medulloblastoma. An important gene associated with Medulloblastoma is SUFU (suppressor of fused homolog (Drosophila)), and among its related pathways are Signaling events mediated by the Hedgehog family and TP53 network. The drug carmustine and the compounds 1-hydroxyanthraquinone and methylazoxymethanol acetate have been mentioned in the context of this disorder. Affiliated tissues include the lower part of the brain, brain and cerebellum, and related mouse phenotypes are pigmentation and hearing/vestibular/ear.

Disease Ontology:8 An infratentorial cancer that is located in the lower part of the brain and is a type of primitive neuroectodermal tumor.

Wikipedia:64 Medulloblastoma is a highly malignant primary brain tumor (cancer) that originates in the part of the... more...

Related Diseases for Medulloblastoma

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Diseases in the Medulloblastoma family:

Adult Medulloblastoma Medulloblastoma, Sufu-Related

Diseases related to Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1childhood medulloblastoma32.1ERBB4, ERBB3, MYC
2basal cell carcinoma31.4CTNNB1, SUFU, PTCH1
3glioblastoma31.2DMBT1, GFAP, PTCH1, MYC, ERBB3
4basal cell nevus syndrome31.2SUFU, PTCH1, PTCH2
5mismatch repair cancer syndrome31.0APC, CTNNB1
6adenomatous polyposis coli30.8APC, CTNNB1
7pineoblastoma30.8GFAP, SAG
8glioblastoma multiforme30.7ERBB3, GFAP, DMBT1
9adenoma30.6CTNNB1, SSTR2, SAG, MYC, APC
10malignant glioma30.5DMBT1, GFAP, SSTR2, NTRK3, ERBB3, ERBB4
11brain cancer30.3DMBT1, ERBB4, NTRK3, APC, PTCH1, GFAP
12retinoblastoma30.3GFAP, APC, BRCA2, MYC, SAG
13breast cancer30.3BRCA2, MYC
14adenocarcinoma30.0DMBT1, PTCH1, APC, BRCA2, MYC, SSTR2
15cerebellar medulloblastoma10.9
16adult medulloblastoma10.7
17neuroectodermal tumor10.7
18neuronitis10.6
19astrocytoma10.6
20basal cell carcinoma, somatic10.5PTCH1, PTCH2
21intestinal neoplasm10.5APC, CTNNB1
22polyposis, juvenile intestinal10.5APC
23hepatocellular adenoma10.5APC, CTNNB1
24desmoid disease, hereditary10.5CTNNB1, APC
25meningioma, familial10.5SSTR2, PTCH1, GFAP
26large cell medulloblastoma10.5
27thyroid carcinoma, papillary10.5PTCH1, APC, CTNNB1
28rhabdoid tumor10.4
29gastric adenocarcinoma10.4APC, MYC, SSTR2, CTNNB1
30pineocytoma10.4SAG, GFAP
31colorectal cancer10.4CTNNB1, APC
32stomach cancer10.4APC, MYC, ERBB3, CTNNB1
33transitional cell carcinoma10.4ERBB4, ERBB3, PTCH1
34atypical teratoid rhabdoid tumor10.4
35supratentorial primitive neuroectodermal tumor10.4
36ependymoma10.4
37prostate cancer10.4MYC, ERBB3, ERBB4, CTNNB1
38melanotic medulloblastoma10.4
39classic medulloblastoma10.3
40gastrinoma10.3SSTR2, APC
41fibromatosis10.3APC, CTNNB1
42tongue squamous cell carcinoma10.3DMBT1, PTCH1, APC, MYC, ERBB3, ERBB4
43peutz-jeghers syndrome10.3CTNNB1, BRCA2, APC
44mutism10.3
45nodular medulloblastoma10.3
46cerebellar astrocytoma10.3
47pilocytic astrocytoma10.3
48medulloblastoma with extensive nodularity10.3
49pancreatic cancer10.3CTNNB1, ERBB3, SSTR2, BRCA2
50nijmegen breakage syndrome10.3

Graphical network of the top 20 diseases related to Medulloblastoma:



Diseases related to medulloblastoma

Symptoms for Medulloblastoma

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Symptoms by clinical synopsis from OMIM:

155255

Clinical features from OMIM:

155255

HPO human phenotypes related to Medulloblastoma:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of metabolism/homeostasis HP:0001939
3 medulloblastoma HP:0002885

Drugs & Therapeutics for Medulloblastoma

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Drug clinical trials:

Search ClinicalTrials for Medulloblastoma

Search NIH Clinical Center for Medulloblastoma

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Medulloblastoma

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Genetic tests related to Medulloblastoma:

id Genetic test Affiliating Genes
1 Medulloblastoma22

Anatomical Context for Medulloblastoma

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MalaCards organs/tissues related to Medulloblastoma:

31
Brain, Cerebellum, Bone, Bone marrow, Thyroid, Breast, Pituitary, Kidney, Skin, Testes, Myeloid, Endothelial, Fetal brain, Spinal cord, Heart, Colon, Liver, T cells, Parietal lobe, Pineal

FMA organs/tissues related to Medulloblastoma:

14
The lower part of the brain

Animal Models for Medulloblastoma or affiliated genes

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MGI Mouse Phenotypes related to Medulloblastoma:

35 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.1APC, PTCH1, SUFU, MYC, ERBB3, OTX2
2MP:000537710.1MYC, DMBT1, APC, NTRK3, CTNNB1, OTX2
3MP:000537110.0PTCH1, BRCA2, MYC, CTNNB1, APC
4MP:000200610.0BRCA2, ERBB3, DMBT1, PTCH2, PTCH1, APC
5MP:00053829.9CTNNB1, PTCH1, MYC, APC, ERBB4, SUFU
6MP:00053909.9OTX2, CTNNB1, ZIC1, MYC, PTCH1, SUFU
7MP:00053919.9CTNNB1, GFAP, NTRK3, OTX2, PTCH1, APC
8MP:00053799.9ERBB4, BRCA2, APC, PTCH1, OTX2, ERBB3
9MP:00107719.9MYC, PTCH2, PTCH1, APC, SUFU, CTNNB1
10MP:00053699.8OTX2, CTNNB1, ZIC1, MYC, ERBB3, APC
11MP:00053809.8CTNNB1, ERBB3, MYC, BRCA2, SUFU, APC
12MP:00030129.8MYC, CTNNB1, PTCH1, APC, SUFU, NTRK3
13MP:00053899.8OTX2, APC, PTCH2, PTCH1, BRCA2, MYC
14MP:00053879.7ERBB4, ERBB3, BRCA2, GFAP, PTCH2, PTCH1
15MP:00053819.7PTCH2, CTNNB1, ERBB3, DMBT1, GFAP, PTCH1
16MP:00053859.6MYC, ERBB3, NTRK3, SSTR2, SUFU, APC
17MP:00053849.6CTNNB1, GFAP, DMBT1, PTCH1, APC, BRCA2
18MP:00053789.6ERBB3, ZIC1, NTRK3, GFAP, MYC, BRCA2
19MP:00053889.6CTNNB1, PTCH1, ERBB3, OTX2, ERBB4, NTRK3
20MP:00028739.6GFAP, SUFU, ERBB3, ERBB4, CTNNB1, OTX2
21MP:00053769.5OTX2, MYC, SUFU, APC, GFAP, DMBT1
22MP:00107689.4PTCH1, DMBT1, OTX2, CTNNB1, APC, GFAP
23MP:00053869.4ZIC1, NTRK3, SSTR2, SRRM4, OTX2, CTNNB1
24MP:00036319.1OTX2, GFAP, PTCH2, PTCH1, APC, SUFU

Publications for Medulloblastoma

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Articles related to Medulloblastoma:

(show top 50)    (show all 1305)
idTitleAuthorsYear
1
Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma. (25821199)
2015
2
Deep Sequencing Identifies IDH1 R132S Mutation in Adult Medulloblastoma. (24616312)
2014
3
Quality of Survival and Growth in Children and Young Adults in the PNET4 European Controlled Trial of Hyperfractionated Versus Conventional Radiation Therapy for Standard-Risk Medulloblastoma. (24239386)
2014
4
Multiplex meta-analysis of medulloblastoma expression studies with external controls. (24297537)
2014
5
Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma. (24280485)
2013
6
Time perception in children treated for a cerebellar medulloblastoma. (23063729)
2013
7
Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma. (23013267)
2013
8
Three down and one to go: modeling medulloblastoma subgroups. (22340583)
2012
9
Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells. (21685941)
2012
10
Genetic alterations in microRNAs in medulloblastomas. (21793975)
2012
11
Characterization of ectonucleotidases in human medulloblastoma cell lines: ecto-5'NT/CD73 in metastasis as potential prognostic factor. (23094051)
2012
12
Cerebrospinal fluid shunting and hearing loss in patients treated for medulloblastoma. (22462709)
2012
13
A tale of two tumors: pediatric and adult medulloblastoma. (23330354)
2012
14
Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a Children's Oncology Group Phase I/II study. (22665539)
2012
15
VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells. (21885916)
2011
16
Myogenic and melanotic differentiated medulloblastoma: case report. (21845588)
2011
17
Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients. (21918172)
2011
18
MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma. (21931765)
2011
19
Appraisal of the current staging system for residual medulloblastoma by volumetric analysis. (21814819)
2011
20
Medulloblastoma and gliomatosis cerebri: rare brain tumors in multiple sclerosis patients. (21234776)
2011
21
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. (19270706)
2009
22
Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas. (18068533)
2008
23
Activation of PPARalpha inhibits IGF-I-mediated growth and survival responses in medulloblastoma cell lines. (18546270)
2008
24
Correlative analyses of notch signaling with resveratrol-induced differentiation and apoptosis of human medulloblastoma cells. (18456406)
2008
25
Two new patients with Curry-Jones syndrome with trichoblastoma and medulloblastoma suggest an etiologic role of the sonic hedgehog-patched-GLI pathway. (18798318)
2008
26
Differential prefrontal-like deficit in children after cerebellar astrocytoma and medulloblastoma tumor. (18412947)
2008
27
Implication of active Erk in the classic type of human medulloblastoma. (18587705)
2008
28
Rectal adenocarcinoma following cranio-spinal radiotherapy for cerebellar medulloblastoma. (17103217)
2007
29
Hedgehog signaling promotes medulloblastoma survival via Bc/II. (17200206)
2007
30
Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis. (17452456)
2007
31
Multifocal desmoplastic medulloblastoma in an african-american child with nevoid basal cell carcinoma (gorlin) syndrome. Case report. (17328283)
2006
32
Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16. (15767543)
2005
33
E, N-cadherins and beta-catenin expression in medulloblastoma and atypical teratoid/rhabdoid tumor. (15508347)
2004
34
Diffusion-weighted MR imaging and pathologic findings in adult cerebellar medulloblastoma. (15356452)
2004
35
Effects of radiation treatment planning and patient fixation on the results of postoperative radiotherapy of childhood medulloblastoma. (14652675)
2003
36
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. (12872164)
2003
37
MDM2 overexpression is associated with short survival in adults with medulloblastoma. (11916503)
2002
38
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. (11212243)
2001
39
Evolution of malignant cerebellar astrocytoma at the site of a treated medulloblastoma: report of two cases. (11534690)
2001
40
Intense p53 staining is a valuable prognostic indicator for poor prognosis in medulloblastoma/central nervous system primitive neuroectodermal tumors. (11451203)
2001
41
Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas. (9973222)
1999
42
Expression of platelet-derived growth factor transcripts in medulloblastomas and ependymomas. (8841077)
1996
43
Prognostic factors in adult medulloblastoma. A clinico-pathologic study. (8804450)
1995
44
Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines. (17180032)
1995
45
Immunocytochemical demonstration of interphotoreceptor retinoid-binding protein in cerebellar medulloblastoma. (1377856)
1992
46
Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes. (1756496)
1991
47
Establishment and characterization of human medulloblastoma xenograft line. (1864766)
1991
48
Medulloblastoma cells constitutively produce granulocyte colony-stimulating factor. (1697636)
1990
49
Cerebellar medulloblastoma: the importance of posterior fossa dose to survival and patterns of failure. (6818190)
1982
50
Unilateral papilloedema in cerebellar medulloblastoma. (756436)
1978

Variations for Medulloblastoma

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UniProtKB/Swiss-Prot genetic disease variations for Medulloblastoma:

63
id Symbol AA change Variation ID SNP ID
1APCp.Ala1296ValVAR_017653
2APCp.Val1472IleVAR_017654
3APCp.Ser1495GlyVAR_017655
4CTNNB1p.Ser33PheVAR_017617
5CTNNB1p.Ser37AlaVAR_017624

Clinvar genetic disease variations for Medulloblastoma:

5
id Gene Variation Type Significance SNP ID Assembly Location
1CTNNB1NM_001904.3(CTNNB1): c.98C> T (p.Ser33Phe)single nucleotide variantPathogenicrs121913400GRCh37Chr 3, 41266101: 41266101
2SUFUNM_016169.3(SUFU): c.44C> T (p.Pro15Leu)single nucleotide variantPathogenicrs28942088GRCh37Chr 10, 104263953: 104263953
3SUFUNM_016169.3(SUFU): c.1022+1G> Asingle nucleotide variantPathogenicGRCh37Chr 10, 104359302: 104359302
4PTCH2NM_001166292.1(PTCH2): c.1172_1173delCT (p.Ser391Terfs)deletionPathogenicrs56126236GRCh37Chr 1, 45295116: 45295117
5BRCA2NM_000059.3(BRCA2): c.658_659delGT (p.Val220Ilefs)deletionPathogenic, risk factorrs80359604GRCh37Chr 13, 32903606: 32903607
6BRCA2NM_000059.3(BRCA2): c.5645C> G (p.Ser1882Ter)single nucleotide variantPathogenic, risk factorrs80358785GRCh37Chr 13, 32914137: 32914137

Expression for genes affiliated with Medulloblastoma

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Search GEO for disease gene expression data for Medulloblastoma.

Pathways for genes affiliated with Medulloblastoma

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Pathways related to Medulloblastoma according to GeneCards Suite gene sharing:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PTCH2, PTCH1
2
Show member pathways
10.3OTX2, MYC
3
Show member pathways
10.2PTCH1, SUFU, PTCH2
410.2CTNNB1, MYC, BRCA2
5
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
10.2APC, CTNNB1, MYC
610.2MYC, CTNNB1, APC
710.2APC, MYC, CTNNB1
8
Show member pathways
Signal transduction PTEN pathway59
10.2MYC, APC, CTNNB1
910.2APC, CTNNB1, MYC
1010.2CTNNB1, MYC, APC
1110.2CTNNB1, MYC, APC
1210.2APC, CTNNB1, NTRK3
13
Show member pathways
10.2CTNNB1, NTRK3, APC
1410.2ERBB3, ERBB4, CTNNB1
15
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
10.2ERBB4, ERBB3, MYC
1610.1NTRK3, ERBB3, ERBB4
1710.1APC, CTNNB1, BRCA2, MYC
18
Show member pathways
Signaling Pathways in Glioblastoma36
10.1MYC, ERBB3, BRCA2, CTNNB1
1910.1MYC, ZIC1, CTNNB1, GFAP
20
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
10.1MYC, ERBB4, CTNNB1, ERBB3
2110.1OTX2, NTRK3, GFAP, SAG
22
Show member pathways
10.1CTNNB1, ERBB3, NTRK3, ERBB4
23
Show member pathways
10.1PTCH1, PTCH2, SUFU, CTNNB1, APC
2410.0ERBB3, ERBB4, MYC, NTRK3
25
Show member pathways
10.0APC, NTRK3, ERBB3, ERBB4, CTNNB1
2610.0ERBB3, MYC, ERBB4, PTCH1, CTNNB1
2710.0PTCH2, PTCH1, CTNNB1, SUFU, APC, OTX2
28
Show member pathways
10.0NTRK3, ERBB4, ERBB3, MYC, BRCA2
29
Show member pathways
9.9NTRK3, SUFU, ERBB4, ERBB3, CTNNB1, PTCH2
309.9MYC, CTNNB1, PTCH1, BRCA2, SUFU, APC
31
Show member pathways
9.6ERBB4, ERBB3, NTRK3, MYC, SUFU, APC
32
Show member pathways
9.5CTNNB1, GFAP, PTCH2, PTCH1, APC, MYC

Compounds for genes affiliated with Medulloblastoma

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Compounds related to Medulloblastoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
11-hydroxyanthraquinone4410.7APC, CTNNB1
2methylazoxymethanol acetate4410.7CTNNB1, APC
3samp4410.7CTNNB1, APC
4neuregulin-12810.6ERBB3, ERBB4
5neuregulin-22810.6ERBB4, ERBB3
6cyclopamine44 6011.6MYC, PTCH1, CTNNB1
71,2-dimethylhydrazine4410.6CTNNB1, APC
8iressa6010.6ERBB3, ERBB4
9hrgbeta14410.6MYC, ERBB3, ERBB4
10jnj 28871063 hydrochloride6010.6ERBB4, ERBB3
11ag 1478 hydrochloride6010.6ERBB3, ERBB4
12ag 4906010.6ERBB4, ERBB3
13pertuzumab44 50 1112.6ERBB3, ERBB4
14cetuximab44 50 1112.5ERBB3, ERBB4, CTNNB1
15o-tyrosine4410.5ERBB3, NTRK3
16azoxymethane4410.5APC, CTNNB1
17trastuzumab44 50 1112.5CTNNB1, ERBB4, ERBB3
18guanine44 24 1112.4CTNNB1, SSTR2, SAG, APC
194-hydroxytamoxifen4410.4BRCA2, CTNNB1, MYC
20glutamine4410.4BRCA2, APC, GFAP, SAG, CTNNB1
21nmda44 2811.4APC, CTNNB1, ERBB4, NTRK3, GFAP
22agar4410.4ERBB4, ERBB3, CTNNB1, GFAP, MYC
23matrigel4410.4BRCA2, CTNNB1, NTRK3, GFAP
24phosphoinositide4410.4ERBB3, SAG, ERBB4, CTNNB1, APC
25thymidine44 2411.4CTNNB1, SSTR2, MYC, BRCA2, GFAP
26gefitinib44 50 1112.3CTNNB1, ERBB4, ERBB3
27cycloheximide4410.3GFAP, CTNNB1, NTRK3, MYC, BRCA2, APC
28genistein44 28 60 1 24 1115.3MYC, CTNNB1, ERBB3, ERBB4, GFAP, BRCA2
29tamoxifen44 50 28 1113.3BRCA2, MYC, SSTR2, ERBB3, ERBB4, CTNNB1
30oligonucleotide4410.3ERBB3, CTNNB1, APC, BRCA2, MYC, OTX2
312-amino-3-methylimidazo(4,5-f)quinoline4410.3APC, CTNNB1
32testosterone44 60 24 1113.3GFAP, APC, BRCA2, ERBB3, NTRK3, CTNNB1
33phosphotyrosine4410.3ERBB3, CTNNB1, SSTR2, ERBB4
34dopamine44 28 24 1113.3CTNNB1, ERBB4, SSTR2, SAG, APC, GFAP
35cisplatin44 50 60 1113.3ERBB4, GFAP, BRCA2, KLC1, CTNNB1, MYC
36alpha-amanitin4410.3MYC, GFAP
37linoleic acid28 44 2412.3ERBB3, CTNNB1, APC
38paclitaxel44 50 1112.3GFAP, CTNNB1, BRCA2, MYC
39phosphatidylinositol4410.2APC, ERBB3, BRCA2, NTRK3, ERBB4, CTNNB1
40retinoic acid44 2411.2NTRK3, CTNNB1, MYC, BRCA2, APC, GFAP
41progesterone44 28 60 24 1114.2SSTR2, ERBB3, BRCA2, APC, GFAP, ERBB4
42rapamycin4410.2APC, MYC, CTNNB1, ERBB3
43threonine4410.2CTNNB1, NTRK3, SAG, APC, GFAP, ERBB3
44vegf4410.2SSTR2, GFAP, CTNNB1, ERBB3, NTRK3, MYC
45estrogen4410.1CTNNB1, SSTR2, ERBB4, GFAP, APC, ERBB3
46paraffin4410.0ERBB3, GFAP, SSTR2, PTCH1, APC, BRCA2
47serine4410.0MYC, CTNNB1, GFAP, APC, DMBT1, ERBB3
48glycogen44 2411.0MYC, CTNNB1, APC, GFAP
49p002449.9ERBB3, CTNNB1, BRCA2
50tyrosine449.9MYC, APC, PTCH1, GFAP, SAG, SSTR2

GO Terms for genes affiliated with Medulloblastoma

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Cellular components related to Medulloblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:003087710.4CTNNB1, APC
2lateral plasma membraneGO:001632810.3CTNNB1, ERBB3, APC
3primary ciliumGO:007237210.3SUFU, PTCH1
4axonal growth coneGO:004429510.3PTCH1, APC
5receptor complexGO:004323510.0ERBB4, ERBB3, NTRK3
6basolateral plasma membraneGO:00163239.9CTNNB1, ERBB4, ERBB3
7cytoplasmGO:00057379.7DMBT1, GFAP, APC, SUFU, BRCA2, SSTR2

Biological processes related to Medulloblastoma according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:004433610.5CTNNB1, APC
2negative regulation of cell divisionGO:005178210.5PTCH1, MYC
3negative regulation of smoothened signaling pathwayGO:004587910.5PTCH2, PTCH1, SUFU
4regulation of smoothened signaling pathwayGO:000858910.5OTX2, ZIC1, PTCH1
5positive regulation of epithelial cell differentiationGO:003085810.5APC, DMBT1
6dorsal/ventral pattern formationGO:000995310.5OTX2, APC, PTCH1
7branching involved in ureteric bud morphogenesisGO:000165810.5PTCH1, MYC, CTNNB1
8inner cell mass cell proliferationGO:000183310.4BRCA2, DMBT1
9mammary gland epithelial cell differentiationGO:006064410.4ERBB4, PTCH1
10canonical Wnt signaling pathwayGO:006007010.4APC, MYC, CTNNB1
11cell fate specificationGO:000170810.4CTNNB1, OTX2
12transmembrane receptor protein tyrosine kinase signaling pathwayGO:000716910.4NTRK3, ERBB3, ERBB4
13positive regulation of transcription, DNA-templatedGO:004589310.2BRCA2, MYC, ZIC1, ERBB4, CTNNB1, OTX2
14brain developmentGO:000742010.2ZIC1, BRCA2, PTCH1
15chromosome organizationGO:005127610.2APC, MYC
16negative regulation of cell proliferationGO:000828510.1CTNNB1, ERBB4, SSTR2, APC
17proximal/distal pattern formationGO:000995410.0CTNNB1, APC

Molecular functions related to Medulloblastoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1hedgehog family protein bindingGO:009710810.4PTCH2, PTCH1
2smoothened bindingGO:000511910.4PTCH2, PTCH1
3cadherin bindingGO:004529610.3CTNNB1, APC
4hedgehog receptor activityGO:000815810.3PTCH1, PTCH2
5protein complex bindingGO:003240310.1PTCH1, MYC, CTNNB1
6repressing transcription factor bindingGO:007049110.0CTNNB1, MYC
7protein bindingGO:00055159.3OTX2, DMBT1, PTCH1, APC, H2AFY, SUFU

Sources for Medulloblastoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet