MCID: MDL002
MIFTS: 39

Medulloepithelioma malady

Neuronal, Cancer categories

Summaries for Medulloepithelioma

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64Wikipedia, 33MalaCards
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Wikipedia:64 Medulloepithelioma is a rare, primitive, fast growing brain tumour thought to stem from cells of the... more...

MalaCards: Medulloepithelioma, also known as medulloepithelioma, central nervous system, is related to ependymoma and teratoma. An important gene associated with Medulloepithelioma is NES (nestin), and among its related pathways is Cytoskeleton remodeling Neurofilaments. The compounds mucicarmine and n-acetylaspartate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and kidney, and related mouse phenotypes are normal and nervous system.

Aliases & Classifications for Medulloepithelioma

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
medulloepithelioma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

medulloepithelioma 8 10 49 61
medulloepithelioma, central nervous system 8
medulloepithelioma nos 8
diktyoma, malignant 8


External Ids:

Disease Ontology8 DOID:4790
MeSH35 D018242
SNOMED-CT57 39005004, 189932005

Related Diseases for Medulloepithelioma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Medulloepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1ependymoma29.9NES, SYP, GFAP
2teratoma29.9TERT, GFAP, NES
3adenoma29.9TERT, KRT20, SYP, NES
4adenocarcinoma29.9NES, SYP, KRT20, TERT
5intraocular medulloepithelioma10.6
6blastoma10.1
7pleuropulmonary blastoma10.1
8uveitis10.1
9gastrointestinal stromal tumor10.0NES
10chordoma10.0GFAP
11giant cell glioblastoma10.0GFAP
12gliomatosis cerebri10.0GFAP
13dysembryoplastic neuroepithelial tumor10.0SYP
14papilloma10.0KRT20
15neuroblastoma10.0SYP
16syringoma10.0GFAP
17rhabdoid tumor10.0SYP
18melanotic neuroectodermal tumor10.0SYP
19anaplastic oligodendroglioma10.0GFAP
20leiomyoma10.0NES
21rhabdomyosarcoma10.0NES
22ganglioneuroblastoma10.0SYP
23granular cell tumor10.0SYP
24anaplastic astrocytoma10.0NES, GFAP
25neurofibroma10.0SYP
26merkel cell carcinoma10.0SYP
27subependymal giant cell astrocytoma10.0GFAP, SYP
28ganglioglioma10.0GFAP, SYP
29binswanger's disease10.0SYP, GFAP
30papillary ependymoma10.0SYP, GFAP
31central neurocytoma10.0SYP, GFAP
32paraganglioma10.0SYP, GFAP
33choroid plexus papilloma10.0GFAP, SYP
34coloboma10.0
35anterior uveitis10.0
36cataract-glaucoma10.0
37persistent hyperplastic primary vitreous10.0
38pineocytoma10.0SYP, GFAP
39oligodendroglioma10.0GFAP, SYP
40pineoblastoma10.0GFAP, SYP
41tubular adenocarcinoma10.0KRT20, SYP
42prion disease10.0SYP, GFAP
43large cell carcinoma10.0KRT20, SYP
44neurilemmoma10.0NES, GFAP
45sarcoma10.0NES, TERT
46oxyphilic adenoma10.0SYP, KRT20
47neuroendocrine carcinoma10.0SYP, KRT20
48pituitary adenoma10.0NES, SYP
49ganglioneuroma10.0GFAP, SYP
50malignant peripheral nerve sheath tumor10.0TERT, NES

Graphical network of the top 20 diseases related to Medulloepithelioma:



Diseases related to medulloepithelioma

Clinical Features for Medulloepithelioma

Drugs & Therapeutics for Medulloepithelioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Medulloepithelioma

Anatomical Context for Medulloepithelioma

Sources:
33MalaCards
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MalaCards organs/tissues related to Medulloepithelioma:

33
Spinal cord, Brain, Kidney, Bone marrow, Retina, Fetal brain, Ciliary ganglion, Pons

Animal Models for Medulloepithelioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Medulloepithelioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.1TERT, GFAP, INA, SYP
2MP:00036317.3TERT, GFAP, INA, SYP, NES

Publications for Medulloepithelioma

Sources:
51PubMed
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Articles related to Medulloepithelioma:

(show top 50)    (show all 145)
idTitleAuthorsYear
1
Ciliary body medulloepithelioma in an adult. (23218809)
2013
2
Primitive neuroectodermal tumour in a striped dolphin (Stenella coeruleoalba) with features of ependymoma and neural tube differentiation (Medulloepithelioma). (24011906)
2013
3
Benign intraocular teratoid medulloepithelioma causing glaucoma in an 11-year-old Arabian mare. (23025750)
2013
4
Imaging features of medulloepithelioma: report of four cases and review of the literature. (23989751)
2013
5
Ciliary body medulloepithelioma: analysis of 41 cases. (23796765)
2013
6
Medulloepithelioma in DICER1 syndrome treated with resection. (23640610)
2013
7
Ciliary body medulloepithelioma in a 10-year-old boy. (22776925)
2012
8
Dilemma in management of ocular medulloepithelioma in a child. (22340579)
2012
9
Ciliary body medulloepithelioma with neoplastic cyclitic membrane imaging with fluorescein angiography and ultrasound biomicroscopy. (21505878)
2011
10
Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation. (19563506)
2010
11
Intraoperative cytodiagnosis of ciliary body medulloepithelioma masquerading as anterior ciliary staphyloma. (20968164)
2010
12
Malignant non-teratoid medulloepithelioma of ciliary body with retinoblastic differentiation: a case report and review of literature. (18410270)
2008
13
Cerebral medulloepithelioma with long survival. (17895618)
2007
14
Unusual clinical and MRI features of a cerebellopontine angle medulloepithelioma. Case report and review of literature. (16902342)
2006
15
Intraocular malignant teratoid medulloepithelioma in an adult: clinicopathological case report and review of the literature. (16637848)
2006
16
Ciliary body medulloepithelioma: clinical, ultrasound biomicroscopic and histopathologic correlation. (16970765)
2006
17
Possible shared pathogenesis of the retinoinvasive phenotype of malignant medulloepithelioma and malignant melanoma of the ciliary body. (16832040)
2006
18
What's your diagnosis? Ciliary body medulloepithelioma. (15724891)
2005
19
Recurrent central nervous system medulloepithelioma: response and outcome following marrow-ablative chemotherapy with stem cell rescue. (15891561)
2005
20
Pigmented malignant medulloepithelioma of the ciliary body. (15609523)
2004
21
Malignant teratoid medulloepithelioma in eye. (16340262)
2003
22
Peripheral medulloepithelioma: an immunohistochemical, ultrastructural, and cytogenetic study of a rare, chemotherapy-sensitive, pediatric tumor. (12826895)
2003
23
Pigmented medulloepithelioma of the ciliary body. (11831926)
2002
24
Sellar and suprasellar medulloepithelioma. (11550774)
2001
25
Successful therapy in a child with a congenital peripheral medulloepithelioma and disruption of hindquarter development. (10206465)
1999
26
Non-rubeotic angle-closure glaucoma associated with ciliary medulloepithelioma. (8876394)
1996
27
Cytogenetic analysis in a case of intraocular medulloepithelioma. (8976372)
1996
28
Central nervous system medulloepithelioma: a series of eight cases including two arising in the pons. (8609554)
1996
29
Occurrence of sequential intraocular tumors: malignant medulloepithelioma subsequent to retinoblastoma. (8295368)
1993
30
Ultrastructural pleomorphism in medulloepithelioma of the ciliary body: a comparative study of tumour cells and fetal ciliary epithelium. (2079780)
1990
31
Malignant teratoid medulloepithelioma of the ciliary body simulating persistent hyperplastic primary vitreous. (2923158)
1989
32
Medulloepithelioma (diktyoma). (3056510)
1988
33
Medulloepithelioma: MRI appearances. (3248094)
1988
34
Malignant teratoid medulloepithelioma in a horse. (3558068)
1987
35
Medulloepithelioma of the ciliary body. (3841866)
1985
36
Spinal cord medulloepithelioma in a dog. (6501052)
1984
37
Medulloepithelioma (diktyoma) with glial differentiation. (6520564)
1984
38
Medulloepithelioma diagnosed by ultrasound and vitreous aspirate. Electron microscopic observations. (6677853)
1983
39
Peripheral medulloepithelioma. (7124342)
1982
40
Medulloepithelioma arising from the posterior pole. (7231881)
1980
41
Pathology of a unique type of teratoid medulloepithelioma. (427073)
1979
42
Malignant teratoid medulloepithelioma in an adult. (426684)
1979
43
Malignant medulloepithelioma of the optic nerve in a horse. (695223)
1978
44
Teratoid intraocular medulloepithelioma. (677212)
1978
45
Fine structure of medulloepithelioma. (886367)
1977
46
Electron microscopic diagnosis of medulloepithelioma. (1115200)
1975
47
Medulloepithelioma involving the iris. (1138856)
1975
48
Malignant teratoid medulloepithelioma of the optic nerve. (4827430)
1974
49
Primary malignant medulloepithelioma of the retinal stalk. (4206617)
1974
50
Medulloepithelioma: definition of an entity. (5060129)
1972

Genetic Variations for Medulloepithelioma

Expression for genes affiliated with Medulloepithelioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Medulloepithelioma

Search GEO for disease gene expression data for Medulloepithelioma.

Pathways for genes affiliated with Medulloepithelioma

Sources:
12EMD Millipore
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Pathways related to Medulloepithelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.6GFAP, INA, NES

Compounds for genes affiliated with Medulloepithelioma

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Medulloepithelioma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1mucicarmine459.8KRT20, SYP
2n-acetylaspartate459.7SYP, GFAP
3b 723459.7KRT20, SYP
4s 100459.7GFAP, SYP
5reticulin459.7SYP, GFAP
62-mercaptoethanol459.7GFAP, NES
7dutp459.6GFAP, SYP
8silver459.4GFAP, SYP
9streptozotocin459.4NES, SYP, GFAP
10ganglioside459.3NES, SYP, GFAP
11kainate45 2910.3GFAP, SYP, NES
12choline45 11 2411.3GFAP, SYP, NES
13gaba459.2NES, SYP, GFAP
14hematoxylin459.2KRT20, GFAP, SYP
15ganciclovir45 1110.2GFAP, TERT
16acetylcholine45 50 29 11 2413.2NES, SYP, GFAP
17formaldehyde45 2410.2KRT20, GFAP, SYP
18dbc-amp459.1GFAP, SYP
19dopamine45 29 11 2412.1NES, SYP, GFAP
20genistein45 29 60 2 11 2414.0SYP, GFAP, TERT
21cisplatin45 50 60 1111.9TERT, GFAP, SYP
22progesterone45 60 29 11 2412.8NES, SYP, GFAP, KRT20
23testosterone45 60 11 2411.7SYP, GFAP, KRT20, TERT
24lipid458.6TERT, GFAP, SYP, NES
25paraffin458.3TERT, KRT20, GFAP, SYP, NES
26vegf458.3NES, SYP, GFAP, KRT20, TERT
27estrogen458.3TERT, KRT20, GFAP, SYP, NES
28tyrosine458.2NES, SYP, GFAP, KRT20, TERT
29retinoic acid45 249.0NES, SYP, INA, GFAP, TERT

GO Terms for genes affiliated with Medulloepithelioma

Sources:
16Gene Ontology
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Cellular components related to Medulloepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.9KRT20, GFAP, NES

Biological processes related to Medulloepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:0451099.3KRT20, GFAP

Molecular functions related to Medulloepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052008.5KRT20, GFAP, INA

Products for genes affiliated with Medulloepithelioma

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  • Proteins
  • Lysates
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Sources for Medulloepithelioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet