MCID: MDL002
MIFTS: 45

Medulloepithelioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Medulloepithelioma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Medulloepithelioma is a rare, primitive, fast growing brain tumour thought to stem from cells of the... more...

MalaCards: Medulloepithelioma, also known as medulloepithelioma, central nervous system, is related to rhabdomyosarcoma and pineoblastoma. An important gene associated with Medulloepithelioma is NES (nestin), and among its related pathways is Cytoskeleton remodeling Neurofilaments. The compounds mucicarmine and n-acetylaspartate have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina, and related mouse phenotypes are normal and nervous system.

Aliases & Classifications for Medulloepithelioma

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8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
medulloepithelioma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

medulloepithelioma 8 10 48 60
medulloepithelioma, central nervous system 8
medulloepithelioma nos 8
diktyoma, malignant 8


External Ids:

Disease Ontology8 DOID:4790
MeSH34 D018242
SNOMED-CT56 39005004, 189932005
SNOMED-CT via Orphanet57 39005004

Related Diseases for Medulloepithelioma

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17GeneCards, 18GeneDecks
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Diseases related to Medulloepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma29.9NES
2pineoblastoma29.8GFAP, SYP
3retinoblastoma29.8SYP, GFAP, TERT
4adenoma29.8TERT, KRT20, SYP, NES
5malignant glioma29.8NES, SYP, GFAP, TERT
6adenocarcinoma29.8NES, SYP, KRT20, TERT
7cerebritis10.4
8intraocular medulloepithelioma10.2
9glaucoma10.2
10retinitis10.2
11blastoma10.1
12pleuropulmonary blastoma10.1
13uveitis10.1
14gastrointestinal stromal tumor10.0NES
15chordoma10.0GFAP
16giant cell glioblastoma10.0GFAP
17gliomatosis cerebri10.0GFAP
18dysembryoplastic neuroepithelial tumor10.0SYP
19neuroblastoma10.0SYP
20papilloma10.0KRT20
21syringoma10.0GFAP
22rhabdoid tumor10.0SYP
23anaplastic oligodendroglioma10.0GFAP
24melanotic neuroectodermal tumor10.0SYP
25leiomyoma10.0NES
26ganglioneuroblastoma10.0SYP
27granular cell tumor10.0SYP
28anaplastic astrocytoma10.0NES, GFAP
29neurofibroma10.0SYP
30merkel cell carcinoma10.0SYP
31subependymal giant cell astrocytoma10.0GFAP, SYP
32ganglioglioma10.0GFAP, SYP
33binswanger's disease10.0SYP, GFAP
34papillary ependymoma10.0SYP, GFAP
35central neurocytoma10.0SYP, GFAP
36paraganglioma10.0SYP, GFAP
37choroid plexus papilloma10.0GFAP, SYP
38pineocytoma10.0SYP, GFAP
39oligodendroglioma10.0GFAP, SYP
40tubular adenocarcinoma10.0KRT20, SYP
41prion disease10.0SYP, GFAP
42large cell carcinoma10.0KRT20, SYP
43neurilemmoma10.0NES, GFAP
44sarcoma10.0NES, TERT
45oxyphilic adenoma10.0SYP, KRT20
46neuroendocrine carcinoma10.0SYP, KRT20
47pituitary adenoma10.0NES, SYP
48ganglioneuroma10.0GFAP, SYP
49malignant peripheral nerve sheath tumor10.0TERT, NES
50neuroendocrine tumor10.0KRT20, SYP

Graphical network of the top 20 diseases related to Medulloepithelioma:



Diseases related to medulloepithelioma

Clinical Features for Medulloepithelioma

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Drugs & Therapeutics for Medulloepithelioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Medulloepithelioma

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Anatomical Context for Medulloepithelioma

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32MalaCards
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MalaCards organs/tissues related to Medulloepithelioma:

32
Eye, Brain, Retina, Bone, Spinal cord, Kidney, Pons

Animal Models for Medulloepithelioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Medulloepithelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.1TERT, GFAP, INA, SYP
2MP:00036317.3TERT, GFAP, INA, SYP, NES

Publications for Medulloepithelioma

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50PubMed
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Articles related to Medulloepithelioma:

(show top 50)    (show all 145)
idTitleAuthorsYear
1
Malignant teratoid medulloepithelioma with retinoblastic and rhabdomyoblastic differentiation. (23791415)
2013
2
Ciliary body medulloepithelioma associated with pleuropulmonary blastoma. (23613510)
2013
3
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. (24337497)
2013
4
Malignant teratoid ciliary body medulloepithelioma in a neonate. (24261320)
2013
5
The masquerades of a childhood ciliary body medulloepithelioma: a case of chronic uveitis, cataract, and secondary glaucoma. (22606494)
2012
6
Medulloepithelioma of the optic disc. (21676432)
2011
7
Curative treatment for central nervous system medulloepithelioma despite residual disease after resection. Report of two cases treated according to the GPHO Protocol HIT 2000 and review of the literature. (22037651)
2011
8
Fine needle aspiration cytology of metastatic ocular medulloepithelioma. (21062379)
2011
9
Ciliary body medulloepithelioma: four cases associated with pleuropulmonary blastoma--a report from the International Pleuropulmonary Blastoma Registry. (21156700)
2011
10
Conservative surgical treatment of medulloepithelioma of the ciliary body. (20212214)
2010
11
Malignant transformation of a medulloepithelioma of the optic nerve. (20497085)
2010
12
Growth of congenital malignant teratoid medulloepithelioma of the ciliary body: a case study. (19669095)
2010
13
Malignant medulloepithelioma of optic nerve head. (18525470)
2008
14
Long-term survival in a child with a central nervous system medulloepithelioma. (18976104)
2008
15
Presacral medulloepithelioma. (18723988)
2008
16
Medulloepithelioma: Two unusual locations. (17300673)
2007
17
Medulloepithelioma masquerading as chronic anterior granulomatous uveitis. (17508050)
2007
18
Intracranial medulloepithelioma. A case report and review of the literature. (17566306)
2007
19
Malignant non-teratoid medulloepithelioma with submandibular metastases. (16023738)
2006
20
Differential diagnosis of anterior chamber cysts with ultrasound biomicroscopy: ciliary body medulloepithelioma. (16445454)
2006
21
Diffuse retinal involvement in malignant nonteratoid medulloepithelioma of ciliary body in an adult. (16087851)
2005
22
Echographic features of a case of malignant intraocular medulloepithelioma. (15615759)
2005
23
Immunohistochemical characterization of a malignant intraocular teratoid medulloepithelioma in a cockatiel. (15644102)
2005
24
Medulloepithelioma of the optic nerve. (14974835)
2004
25
Medulloepithelioma: a case report. (14742946)
2003
26
Medulloepithelioma of the ciliary body. (12194573)
2002
27
Management of medulloepithelioma of the ciliary body with brachytherapy. (12036686)
2002
28
Pluripotent embryonic stem cells developed into medulloepithelioma in nude mice eyes. (15510674)
2002
29
Iris neovascularization in children as a manifestation of underlying medulloepithelioma. (11495310)
2001
30
Echographic features of medulloepithelioma. (11020423)
2000
31
Malignant nonteratoid medulloepithelioma. (9951466)
1999
32
Medulloepithelioma in a cat. (9560905)
1996
33
Fluorescein angiography and ultrasonography of malignant intraocular medulloepithelioma. (8771526)
1996
34
Congenital neoplasms of the nonpigmented ciliary epithelium (medulloepithelioma). (9003333)
1996
35
Ocular medulloepithelioma in a thoroughbred. (8276010)
1993
36
Unilateral benign medulloepithelioma associated with bilateral retinal detachment. (1594190)
1992
37
Ectopic intrapelvic medulloepithelioma: case report. (1528392)
1992
38
Medulloepithelioma of the ciliary body. (1927327)
1991
39
Malignant teratoid medulloepithelioma of the ciliary body. (2150850)
1990
40
Photoreceptor cell differentiation in intraocular medulloepithelioma: an immunohistopathologic study. (2181983)
1990
41
Cerebral medulloepithelioma--electron microscopy and immunohistochemistry. (2360414)
1990
42
Glioneuroma associated with colobomatous dysplasia of the anterior uvea and retina. A case simulating medulloepithelioma. (2622623)
1989
43
Recurrent medulloepithelioma of the ciliary body. Immunohistochemical characteristics. (3211466)
1988
44
Malignant intraocular medulloepithelioma in two cockatiels. (3505940)
1986
45
Cerebral medulloepithelioma with bone, cartilage, and striated muscle. Light microscopic and immunohistochemical study. (6302229)
1983
46
Cerebral medulloepithelioma. Report of a case with multiple divergent neuroepithelial differentiation. (446196)
1979
47
Medulloepithelioma of the ciliary body in the goldfish (Carassius auratus). (664187)
1978
48
Cerebral medulloepithelioma. (5080635)
1972
49
Cerebral medulloepithelioma. Histological and histochemical study of a case. (5010103)
1972
50
Cerebral medulloepithelioma. Case report. (6065130)
1967

Genetic Variations for Medulloepithelioma

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Expression for genes affiliated with Medulloepithelioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Medulloepithelioma

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Pathways for genes affiliated with Medulloepithelioma

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12EMD Millipore
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Pathways related to Medulloepithelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.6GFAP, INA, NES

Compounds for genes affiliated with Medulloepithelioma

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Medulloepithelioma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1mucicarmine449.8KRT20, SYP
2n-acetylaspartate449.7SYP, GFAP
3b 723449.7KRT20, SYP
4s 100449.7GFAP, SYP
5reticulin449.7SYP, GFAP
62-mercaptoethanol449.7GFAP, NES
7dutp449.6GFAP, SYP
8silver449.4GFAP, SYP
9streptozotocin449.4NES, SYP, GFAP
10ganglioside449.3NES, SYP, GFAP
11kainate44 2810.3GFAP, SYP, NES
12choline44 11 2411.3GFAP, SYP, NES
13gaba449.2NES, SYP, GFAP
14hematoxylin449.2KRT20, GFAP, SYP
15ganciclovir44 1110.2GFAP, TERT
16acetylcholine44 49 28 11 2413.2NES, SYP, GFAP
17formaldehyde44 2410.2KRT20, GFAP, SYP
18dbc-amp449.1GFAP, SYP
19dopamine44 28 11 2412.1NES, SYP, GFAP
20genistein44 28 59 2 11 2414.0SYP, GFAP, TERT
21cisplatin44 49 59 1111.9TERT, GFAP, SYP
22progesterone44 59 28 11 2412.8NES, SYP, GFAP, KRT20
23testosterone44 59 11 2411.7SYP, GFAP, KRT20, TERT
24lipid448.6TERT, GFAP, SYP, NES
25paraffin448.3TERT, KRT20, GFAP, SYP, NES
26vegf448.3NES, SYP, GFAP, KRT20, TERT
27estrogen448.3TERT, KRT20, GFAP, SYP, NES
28tyrosine448.2NES, SYP, GFAP, KRT20, TERT
29retinoic acid44 249.0NES, SYP, INA, GFAP, TERT

GO Terms for genes affiliated with Medulloepithelioma

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16Gene Ontology
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Cellular components related to Medulloepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.9KRT20, GFAP, NES

Biological processes related to Medulloepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:0451099.3KRT20, GFAP

Molecular functions related to Medulloepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052008.5KRT20, GFAP, INA

Products for genes affiliated with Medulloepithelioma

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  • Antibodies
  • Proteins
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Sources for Medulloepithelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet