MCID: MDL002
MIFTS: 45

Medulloepithelioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Medulloepithelioma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Medulloepithelioma is a rare, primitive, fast growing brain tumour thought to stem from cells of the... more...

MalaCards: Medulloepithelioma, also known as medulloepithelioma, central nervous system, is related to rhabdomyosarcoma and pineoblastoma. An important gene associated with Medulloepithelioma is NES (nestin), and among its related pathways is Cytoskeleton remodeling Neurofilaments. The compounds mucicarmine and n-acetylaspartate have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina, and related mouse phenotypes are normal and nervous system.

Aliases & Classifications for Medulloepithelioma

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8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
medulloepithelioma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

medulloepithelioma 8 10 48 60
medulloepithelioma, central nervous system 8
medulloepithelioma nos 8
diktyoma, malignant 8


External Ids:

Disease Ontology8 DOID:4790
MeSH34 D018242
SNOMED-CT56 39005004, 189932005
SNOMED-CT via Orphanet57 39005004

Related Diseases for Medulloepithelioma

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17GeneCards, 18GeneDecks
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Diseases related to Medulloepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma29.9NES
2pineoblastoma29.8GFAP, SYP
3retinoblastoma29.8SYP, GFAP, TERT
4adenoma29.8TERT, KRT20, SYP, NES
5malignant glioma29.8NES, SYP, GFAP, TERT
6adenocarcinoma29.8NES, SYP, KRT20, TERT
7cerebritis10.4
8intraocular medulloepithelioma10.2
9glaucoma10.2
10retinitis10.2
11blastoma10.1
12pleuropulmonary blastoma10.1
13uveitis10.1
14gastrointestinal stromal tumor10.0NES
15chordoma10.0GFAP
16giant cell glioblastoma10.0GFAP
17gliomatosis cerebri10.0GFAP
18dysembryoplastic neuroepithelial tumor10.0SYP
19neuroblastoma10.0SYP
20papilloma10.0KRT20
21syringoma10.0GFAP
22rhabdoid tumor10.0SYP
23anaplastic oligodendroglioma10.0GFAP
24melanotic neuroectodermal tumor10.0SYP
25leiomyoma10.0NES
26ganglioneuroblastoma10.0SYP
27granular cell tumor10.0SYP
28anaplastic astrocytoma10.0NES, GFAP
29neurofibroma10.0SYP
30merkel cell carcinoma10.0SYP
31subependymal giant cell astrocytoma10.0GFAP, SYP
32ganglioglioma10.0GFAP, SYP
33binswanger's disease10.0SYP, GFAP
34papillary ependymoma10.0SYP, GFAP
35central neurocytoma10.0SYP, GFAP
36paraganglioma10.0SYP, GFAP
37choroid plexus papilloma10.0GFAP, SYP
38pineocytoma10.0SYP, GFAP
39oligodendroglioma10.0GFAP, SYP
40tubular adenocarcinoma10.0KRT20, SYP
41prion disease10.0SYP, GFAP
42large cell carcinoma10.0KRT20, SYP
43neurilemmoma10.0NES, GFAP
44sarcoma10.0NES, TERT
45oxyphilic adenoma10.0SYP, KRT20
46neuroendocrine carcinoma10.0SYP, KRT20
47pituitary adenoma10.0NES, SYP
48ganglioneuroma10.0GFAP, SYP
49malignant peripheral nerve sheath tumor10.0TERT, NES
50neuroendocrine tumor10.0KRT20, SYP

Graphical network of the top 20 diseases related to Medulloepithelioma:



Diseases related to medulloepithelioma

Clinical Features for Medulloepithelioma

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Drugs & Therapeutics for Medulloepithelioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Medulloepithelioma

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Anatomical Context for Medulloepithelioma

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32MalaCards
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MalaCards organs/tissues related to Medulloepithelioma:

32
Eye, Brain, Retina, Bone, Spinal cord, Kidney, Pons

Animal Models for Medulloepithelioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Medulloepithelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.1TERT, GFAP, INA, SYP
2MP:00036317.3TERT, GFAP, INA, SYP, NES

Publications for Medulloepithelioma

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50PubMed
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Articles related to Medulloepithelioma:

(show top 50)    (show all 145)
idTitleAuthorsYear
1
Ciliary body medulloepithelioma in an adult. (23218809)
2013
2
Primitive neuroectodermal tumour in a striped dolphin (Stenella coeruleoalba) with features of ependymoma and neural tube differentiation (Medulloepithelioma). (24011906)
2013
3
Benign intraocular teratoid medulloepithelioma causing glaucoma in an 11-year-old Arabian mare. (23025750)
2013
4
Medulloepithelioma in DICER1 syndrome treated with resection. (23640610)
2013
5
Ciliary body medulloepithelioma in a 10-year-old boy. (22776925)
2012
6
Atypical clinical presentation and long-term survival in a patient with optic nerve medulloepithelioma: a case report. (22571440)
2012
7
Ciliary body medulloepithelioma with neoplastic cyclitic membrane imaging with fluorescein angiography and ultrasound biomicroscopy. (21505878)
2011
8
Medulloepithelioma of the ciliary body: the delay in diagnosis and frequent initial mismanagement. (21995988)
2011
9
Chemosensitivity of medulloepithelioma. (21724057)
2011
10
Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation. (19563506)
2010
11
Ocular medulloepithelioma chemosensitivity. (20947172)
2010
12
Cerebral medulloepithelioma with long survival. (17895618)
2007
13
Intraocular malignant teratoid medulloepithelioma in an adult: clinicopathological case report and review of the literature. (16637848)
2006
14
Intraocular rhabdomyosarcoma in the sibling of a patient with a cerebellar medulloepithelioma. (16825997)
2006
15
Possible shared pathogenesis of the retinoinvasive phenotype of malignant medulloepithelioma and malignant melanoma of the ciliary body. (16832040)
2006
16
Presacral medulloepithelioma--de novo or teratomatous? (14660310)
2004
17
Pigmented malignant medulloepithelioma of the ciliary body. (15609523)
2004
18
Peripheral medulloepithelioma: an immunohistochemical, ultrastructural, and cytogenetic study of a rare, chemotherapy-sensitive, pediatric tumor. (12826895)
2003
19
Intracerebral medulloepithelioma with a long survival. (12365722)
2002
20
Sellar and suprasellar medulloepithelioma. (11550774)
2001
21
Bilateral ectopia lentis as a presenting feature of medulloepithelioma. (11507586)
2001
22
Presumed bilateral medulloepithelioma. (11231783)
2001
23
Metastatic malignant teratoid medulloepithelioma - a case report and review of the literature. (12045966)
2000
24
Medulloepithelioma of the optic nerve with intradural extension--report of two cases and a review of the literature. (10933227)
2000
25
Malignant teratoid medulloepithelioma in a llama. (11105963)
2000
26
Teratoid malignant medulloepithelioma of the optic nerve: report of a case and review of the literature. (12045984)
1999
27
Malignant nonteratoid medulloepithelioma of the ciliary body in an adult. (9544630)
1998
28
Pigmented medulloepithelioma: report of a case and review of the literature. (9548346)
1998
29
A case of medulloepithelioma of the left eye. (10214448)
1998
30
Medulloepithelioma of the optic nerve head. (9338683)
1997
31
Immunohistochemistry of medulloepithelioma and neural tube. (9353831)
1997
32
Non-rubeotic angle-closure glaucoma associated with ciliary medulloepithelioma. (8876394)
1996
33
Nonteratoid medulloepithelioma of the retina with electron microscopic and immunohistochemical characterization. (9025863)
1996
34
Cytogenetic analysis in a case of intraocular medulloepithelioma. (8976372)
1996
35
Malignant teratoid medulloepithelioma: a case report. (8157327)
1993
36
Concurrent benign teratoid medulloepithelioma and pineoblastoma. (1513537)
1992
37
Basic fibroblast growth factor and somatomedin C in human medulloepithelioma. (1855180)
1991
38
Malignant teratoid medulloepithelioma of the ciliary body simulating persistent hyperplastic primary vitreous. (2923158)
1989
39
Medulloepithelioma: MRI appearances. (3248094)
1988
40
Medulloepithelioma of the ciliary body. (3841866)
1985
41
Malignant teratoid medulloepithelioma manifesting as a black epibulbar mass with expulsive hemorrhage. (6487119)
1984
42
Nonteratoid medulloepithelioma of the ciliary body. (6493721)
1984
43
Intraocular medulloepithelioma in a 79-year-old man. (7177573)
1982
44
Malignant teratoid medulloepithelioma in an adult. (426684)
1979
45
Malignant medulloepithelioma of the optic nerve in a horse. (695223)
1978
46
Teratoid intraocular medulloepithelioma. (677212)
1978
47
Medulloepithelioma (diktyoma) presenting as a perforated, infected eye. (851523)
1977
48
Malignant teratoid medulloepithelioma of the optic nerve. (4827430)
1974
49
Primary malignant medulloepithelioma of the retinal stalk. (4206617)
1974
50
Cerebral medulloepithelioma with maturation into ependymal cells and ganglion cells. (5788941)
1969

Genetic Variations for Medulloepithelioma

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Expression for genes affiliated with Medulloepithelioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Medulloepithelioma

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Pathways for genes affiliated with Medulloepithelioma

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12EMD Millipore
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Pathways related to Medulloepithelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.6GFAP, INA, NES

Compounds for genes affiliated with Medulloepithelioma

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Medulloepithelioma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1mucicarmine449.8KRT20, SYP
2n-acetylaspartate449.7SYP, GFAP
3b 723449.7KRT20, SYP
4s 100449.7GFAP, SYP
5reticulin449.7SYP, GFAP
62-mercaptoethanol449.7GFAP, NES
7dutp449.6GFAP, SYP
8silver449.4GFAP, SYP
9streptozotocin449.4NES, SYP, GFAP
10ganglioside449.3NES, SYP, GFAP
11kainate44 2810.3GFAP, SYP, NES
12choline44 11 2411.3GFAP, SYP, NES
13gaba449.2NES, SYP, GFAP
14hematoxylin449.2KRT20, GFAP, SYP
15ganciclovir44 1110.2GFAP, TERT
16acetylcholine44 49 28 11 2413.2NES, SYP, GFAP
17formaldehyde44 2410.2KRT20, GFAP, SYP
18dbc-amp449.1GFAP, SYP
19dopamine44 28 11 2412.1NES, SYP, GFAP
20genistein44 28 59 2 11 2414.0SYP, GFAP, TERT
21cisplatin44 49 59 1111.9TERT, GFAP, SYP
22progesterone44 59 28 11 2412.8NES, SYP, GFAP, KRT20
23testosterone44 59 11 2411.7SYP, GFAP, KRT20, TERT
24lipid448.6TERT, GFAP, SYP, NES
25paraffin448.3TERT, KRT20, GFAP, SYP, NES
26vegf448.3NES, SYP, GFAP, KRT20, TERT
27estrogen448.3TERT, KRT20, GFAP, SYP, NES
28tyrosine448.2NES, SYP, GFAP, KRT20, TERT
29retinoic acid44 249.0NES, SYP, INA, GFAP, TERT

GO Terms for genes affiliated with Medulloepithelioma

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16Gene Ontology
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Cellular components related to Medulloepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.9KRT20, GFAP, NES

Biological processes related to Medulloepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:0451099.3KRT20, GFAP

Molecular functions related to Medulloepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052008.5KRT20, GFAP, INA

Products for genes affiliated with Medulloepithelioma

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Medulloepithelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet