MCID: MDL002
MIFTS: 43

Medulloepithelioma malady

Neuronal diseases, Cancer diseases, Rare diseases categories
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Summaries for Medulloepithelioma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Medulloepithelioma is a rare, primitive, fast growing brain tumour thought to stem from cells of the... more...

MalaCards: Medulloepithelioma, also known as medulloepithelioma, central nervous system, is related to ependymoma and malignant glioma. An important gene associated with Medulloepithelioma is NES (nestin), and among its related pathways is Cytoplasmic microtubules. The compounds streptozotocin and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina, and related mouse phenotype nervous system.

Aliases & Classifications for Medulloepithelioma

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8Disease Ontology, 10DISEASES, 49Orphanet, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT, 63UMLS via Orphanet, 59SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
medulloepithelioma:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


Aliases & Descriptions:

medulloepithelioma 8 10 49 62
medulloepithelioma, central nervous system 8
medulloepithelioma nos 8
diktyoma, malignant 8


External Ids:

Disease Ontology8 DOID:4790
MeSH35 D018242
SNOMED-CT58 39005004, 189932005
UMLS via Orphanet63 C0334596
SNOMED-CT via Orphanet59 39005004

Related Diseases for Medulloepithelioma

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17GeneCards, 18GeneDecks
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Diseases related to Medulloepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1ependymoma30.0SYP, NES
2malignant glioma29.9TERT, NES, SYP
3adenoma29.8TERT, NES, SYP, KRT20
4adenocarcinoma29.8KRT20, SYP, NES, TERT
5intraocular medulloepithelioma10.5
6cerebritis10.4
7glaucoma10.2
8retinitis10.2
9blastoma10.1
10pleuropulmonary blastoma10.1
11uveitis10.1
12subependymal giant cell astrocytoma10.1SYP
13dysembryoplastic neuroepithelial tumor10.1SYP
14ganglioglioma10.1SYP
15malignant peripheral nerve sheath tumor10.0TERT, NES
16stroke, ischemic10.0NES, INA
17teratoma10.0NES, TERT
18hemangioblastoma10.0SYP, NES
19brain cancer10.0SYP, NES
20pilocytic astrocytoma10.0SYP, NES
21tuberous sclerosis10.0SYP, NES
22glioblastoma multiforme10.0NES, TERT
23pituitary adenoma10.0NES, SYP
24non-small cell lung carcinoma10.0SYP, TERT
25meningioma10.0SYP, TERT
26merkel cell carcinoma10.0SYP, KRT20
27tubular adenocarcinoma10.0KRT20, SYP
28large cell carcinoma10.0SYP, KRT20
29cholangiocarcinoma10.0KRT20, TERT
30amyotrophic lateral sclerosis10.0SYP, NES
31neuroendocrine carcinoma10.0SYP, KRT20
32oxyphilic adenoma10.0SYP, KRT20
33bladder carcinoma10.0KRT20, TERT
34neuroendocrine tumor10.0KRT20, SYP
35pheochromocytoma10.0SYP, TERT
36papillary carcinoma10.0KRT20, SYP
37carcinoid syndrome10.0KRT20, SYP
38astrocytoma10.0SYP, NES, INA
39pancreatic cancer10.0SYP, NES, TERT
40medulloblastoma10.0TERT, NES, SYP
41cataract10.0
42ependymoblastoma10.0
43mediastinitis10.0
44melanoma10.0
45pineoblastoma10.0
46retinal detachment10.0
47retinoblastoma10.0
48rhabdomyosarcoma10.0
49persistent hyperplastic primary vitreous10.0
50lung adenocarcinoma10.0KRT20, TERT

Graphical network of the top 20 diseases related to Medulloepithelioma:



Diseases related to medulloepithelioma

Symptoms for Medulloepithelioma

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Drugs & Therapeutics for Medulloepithelioma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Medulloepithelioma

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Anatomical Context for Medulloepithelioma

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33MalaCards
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MalaCards organs/tissues related to Medulloepithelioma:

33
Eye, Brain, Retina, Bone, Spinal cord, Kidney, Pons

Animal Models for Medulloepithelioma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Medulloepithelioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1SYP, NES, INA, TERT

Publications for Medulloepithelioma

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52PubMed
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Articles related to Medulloepithelioma:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Ciliary body medulloepithelioma in an adult. (23218809)
2013
2
Malignant teratoid medulloepithelioma with retinoblastic and rhabdomyoblastic differentiation. (23791415)
2013
3
Ciliary body medulloepithelioma associated with pleuropulmonary blastoma. (23613510)
2013
4
Ciliary body medulloepithelioma in a 10-year-old boy. (22776925)
2012
5
The masquerades of a childhood ciliary body medulloepithelioma: a case of chronic uveitis, cataract, and secondary glaucoma. (22606494)
2012
6
Ciliary body medulloepithelioma with neoplastic cyclitic membrane imaging with fluorescein angiography and ultrasound biomicroscopy. (21505878)
2011
7
Medulloepithelioma of the optic disc. (21676432)
2011
8
Curative treatment for central nervous system medulloepithelioma despite residual disease after resection. Report of two cases treated according to the GPHO Protocol HIT 2000 and review of the literature. (22037651)
2011
9
Malignant non-teratoid medulloepithelioma of the optic nerve with intraocular extension. (20497433)
2010
10
Conservative surgical treatment of medulloepithelioma of the ciliary body. (20212214)
2010
11
Malignant medulloepithelioma of optic nerve head. (18525470)
2008
12
Diffuse retinal involvement in malignant nonteratoid medulloepithelioma of ciliary body in an adult. (16087851)
2005
13
Echographic features of a case of malignant intraocular medulloepithelioma. (15615759)
2005
14
Immunohistochemical characterization of a malignant intraocular teratoid medulloepithelioma in a cockatiel. (15644102)
2005
15
What's your diagnosis? Ciliary body medulloepithelioma. (15724891)
2005
16
Medulloepithelioma of the optic nerve. (14974835)
2004
17
Intracerebral medulloepithelioma with a long survival. (12365722)
2002
18
Pigmented medulloepithelioma of the ciliary body. (11831926)
2002
19
Malignant teratoid medulloepithelioma: clinical-echographic-histopathologic correlation. (11753262)
2001
20
Iris neovascularization in children as a manifestation of underlying medulloepithelioma. (11495310)
2001
21
Sellar and suprasellar medulloepithelioma. (11550774)
2001
22
Bilateral ectopia lentis as a presenting feature of medulloepithelioma. (11507586)
2001
23
Presumed bilateral medulloepithelioma. (11231783)
2001
24
Successful therapy in a child with a congenital peripheral medulloepithelioma and disruption of hindquarter development. (10206465)
1999
25
Malignant nonteratoid medulloepithelioma of the ciliary body in an adult. (9544630)
1998
26
Medulloepithelioma of the optic nerve head. (9338683)
1997
27
Immunohistochemistry of medulloepithelioma and neural tube. (9353831)
1997
28
Medulloepithelioma in a cat. (9560905)
1996
29
Non-rubeotic angle-closure glaucoma associated with ciliary medulloepithelioma. (8876394)
1996
30
Fluorescein angiography and ultrasonography of malignant intraocular medulloepithelioma. (8771526)
1996
31
Basic fibroblast growth factor and somatomedin C in human medulloepithelioma. (1855180)
1991
32
Medulloepithelioma of the ciliary body. (1927327)
1991
33
Malignant teratoid medulloepithelioma of the ciliary body. (2150850)
1990
34
Glioneuroma associated with colobomatous dysplasia of the anterior uvea and retina. A case simulating medulloepithelioma. (2622623)
1989
35
Medulloepithelioma (diktyoma). (3056510)
1988
36
Medulloepithelioma: MRI appearances. (3248094)
1988
37
Patterns of epithelial metaplasia in malignant gliomas. I. Papillary formations mimicking medulloepithelioma. (2828555)
1988
38
Medulloepithelioma of the ciliary body. (3841866)
1985
39
Malignant teratoid medulloepithelioma manifesting as a black epibulbar mass with expulsive hemorrhage. (6487119)
1984
40
Spinal cord medulloepithelioma in a dog. (6501052)
1984
41
Cerebral medulloepithelioma with bone, cartilage, and striated muscle. Light microscopic and immunohistochemical study. (6302229)
1983
42
Medulloepithelioma diagnosed by ultrasound and vitreous aspirate. Electron microscopic observations. (6677853)
1983
43
Intraocular medulloepithelioma in a 79-year-old man. (7177573)
1982
44
Fine structure of medulloepithelioma. (886367)
1977
45
Electron microscopic diagnosis of medulloepithelioma. (1115200)
1975
46
Malignant teratoid medulloepithelioma of the optic nerve. (4827430)
1974
47
Primary malignant medulloepithelioma of the retinal stalk. (4206617)
1974
48
Medulloepithelioma: definition of an entity. (5060129)
1972
49
Cerebral medulloepithelioma. Case report. (6065130)
1967
50
An autopsy case of metastasizing mediastinal medulloepithelioma. (12998897)
1952

Variations for Medulloepithelioma

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Expression for genes affiliated with Medulloepithelioma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Medulloepithelioma

Search GEO for disease gene expression data for Medulloepithelioma.

Pathways for genes affiliated with Medulloepithelioma

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50PathCards, 12EMD Millipore, 60Thomson Reuters
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Pathways related to Medulloepithelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.2NES, INA

Compounds for genes affiliated with Medulloepithelioma

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Medulloepithelioma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1streptozotocin459.7NES, SYP
2mucicarmine459.7KRT20, SYP
3b 723459.7SYP, KRT20
4ganglioside459.6SYP, NES
5hematoxylin459.6KRT20, SYP
6kainate45 2910.6SYP, NES
7choline45 24 1111.5SYP, NES
8formaldehyde45 2410.3SYP, KRT20
9progesterone45 29 61 24 1113.2KRT20, SYP, NES
10sucrose45 24 1111.1KRT20, SYP
11nitric oxide45 24 1111.0TERT, NES, SYP
12testosterone45 61 24 1112.0TERT, SYP, KRT20
13lipid458.9SYP, NES, TERT
14paraffin458.7KRT20, SYP, NES, TERT
15vegf458.7TERT, NES, SYP, KRT20
16estrogen458.7KRT20, SYP, NES, TERT
17tyrosine458.6KRT20, SYP, NES, TERT
18retinoic acid45 249.3TERT, INA, NES, SYP

GO Terms for genes affiliated with Medulloepithelioma

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16Gene Ontology
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Cellular components related to Medulloepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.5KRT20, NES

Molecular functions related to Medulloepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.1KRT20, INA

Products for genes affiliated with Medulloepithelioma

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Sources for Medulloepithelioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet