MCID: MDL003
MIFTS: 39

Medullomyoblastoma malady

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Medullomyoblastoma

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Aliases & Descriptions for Medullomyoblastoma:

Name: Medullomyoblastoma 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:3861
MeSH36 D008527
SNOMED-CT59 24604009
NCIt42 C3706
UMLS65 C0205833

Summaries for Medullomyoblastoma

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MalaCards based summary: Medullomyoblastoma is related to rhabdomyosarcoma and medulloblastoma, and has symptoms including gait ataxia, vomiting and headache. An important gene associated with Medullomyoblastoma is MB (Myoglobin), and among its related pathways are Notch Pathway and Spinal Cord Injury. Affiliated tissues include brain, colon and lung, and related mouse phenotypes are vision/eye and embryo.

Related Diseases for Medullomyoblastoma

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Diseases related to Medullomyoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma29.6MB, MYCN, MYOD1, MYOG
2medulloblastoma28.9GFAP, MYC, MYCN, OTX2, SMARCB1, SYP
3gastrointestinal adenoma10.8MB, SYP
4supratentorial primitive neuroectodermal tumor10.8INA, SYP
5pediculus humanus capitis infestation10.8GFAP, SYP
6adult malignant schwannoma10.8GFAP, SYP
7skin glomus tumor10.8GFAP, SYP
8anovulation10.8GFAP, SYP
9benign ependymoma10.8GFAP, SYP
10freemartinism10.8MYC, SYP
11peritoneal serous adenocarcinoma10.8SYP, TP63
12mixed glioma10.8GFAP, SYP
13familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis with severe ocular involvement10.7GFAP, SYP
14bone benign neoplasm10.7MB, SYP
15focal chorioretinitis10.7MB, SYP
16pilomyxoid astrocytoma10.7GFAP, SYP
17bilateral hyperactive labyrinth10.7GFAP, SYP
18visual verbal agnosia10.7MB, SYP
19rectum kaposi's sarcoma10.7SMARCB1, SYP
20childhood cerebellar neoplasm10.7GFAP, SMARCB1
21spindle cell liposarcoma10.7MB, TP53
22sarcomatosis10.7MB, TP53
23ependymoblastoma10.7GFAP, SYP
24brain glioma10.7SYP, TP53
25thrombophlebitis10.6GFAP, SMARCB1
26external ear squamous cell carcinoma10.6MB, TP53
27anal gland neoplasm10.6SMARCB1, SYP
28alveoli adenoma10.6GFAP, TP53
29pineal gland astrocytoma10.6GFAP, TP53
30ovarian mucinous cystadenofibroma10.6GFAP, TP53
31fallopian tube serous papilloma10.6SYP, TP53
32congenital disorder of glycosylation, type if10.6GFAP, TP53
33cystic teratoma10.6SYP, TP63
34ischemia10.6MB, MYOG
35baby rattle pelvic dysplasia10.6MYC, TP53
36lateral ventricle meningioma10.6GFAP, TP53
37phagocyte bactericidal dysfunction10.6MB, MYOD1
38high molecular weight kininogen deficiency10.6TP53, TP63
39renal artery disease10.5GFAP, INA
40complement component 3 deficiency10.5GFAP, SMARCB1, SYP
41subependymal giant cell astrocytoma10.5GFAP, TP53
42papillary ependymoma10.5GFAP, SMARCB1, SYP
43eye disease10.5GFAP, TP53
44fibrosarcoma of bone10.5MYC, MYOD1
45vulval paget's disease10.5SMARCB1, TP53
46myoblastoma10.5GFAP, SAG, SYP
47behcet's syndrome arthropathy10.5GFAP, SAG, SYP
48fallopian tube teratoma10.5SYP, TP53
49sebaceous adenocarcinoma10.5GFAP, SMARCB1, TP63
50cerebellar medulloblastoma10.4GFAP, SYP, TP53

Graphical network of the top 20 diseases related to Medullomyoblastoma:



Diseases related to medullomyoblastoma

Symptoms for Medullomyoblastoma

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UMLS symptoms related to Medullomyoblastoma:


gait ataxia, vomiting, headache

Drugs & Therapeutics for Medullomyoblastoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Medullomyoblastoma

Genetic Tests for Medullomyoblastoma

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Anatomical Context for Medullomyoblastoma

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MalaCards organs/tissues related to Medullomyoblastoma:

33
Brain, Colon, Lung, Breast, Thyroid, Pineal, Ovary

Animal Models for Medullomyoblastoma or affiliated genes

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MGI Mouse Phenotypes related to Medullomyoblastoma:

38 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5GFAP, MYCN, OTX2, SAG, SMARCB1, TP53
2MP:00053808.3MB, MYC, MYCN, MYOG, OTX2, SMARCB1
3MP:00053828.2ENO2, MYC, MYCN, OTX2, TP53, TP63
4MP:00053817.9GFAP, MYC, MYCN, OTX2, PPP1R12A, SMARCB1
5MP:00053847.5ENO2, GFAP, MB, MYC, MYCN, OTX2
6MP:00028737.5GFAP, INA, MYC, MYCN, MYOD1, MYOG
7MP:00053887.4ENO2, MB, MYCN, MYOD1, MYOG, OTX2
8MP:00053867.3ENO2, GFAP, MYC, MYCN, MYOG, OTX2
9MP:00036317.2ENO2, GFAP, INA, MYC, MYCN, OTX2
10MP:00053856.9GFAP, MB, MYC, MYCN, MYOD1, OTX2
11MP:00053696.8GFAP, MB, MYC, MYCN, MYOD1, MYOG
12MP:00053766.8GFAP, MB, MYC, MYCN, MYOD1, MYOG
13MP:00107686.4GFAP, MB, MYC, MYCN, MYOD1, MYOG
14MP:00053785.5ENO2, GFAP, MB, MYC, MYCN, MYOD1

Publications for Medullomyoblastoma

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Articles related to Medullomyoblastoma:

(show all 34)
idTitleAuthorsYear
1
Medullomyoblastoma treated with craniospinal radiation and adjuvant chemotherapy: Report of 4 cases and review of the literature. (25936510)
2015
2
Medullomyoblastoma: a case report and literature review of a rare tumor entity. (23155263)
2012
3
Isochromosome 17q, MYC amplification and large cell/anaplastic phenotype in a case of medullomyoblastoma with extracranial metastases. (22147345)
2012
4
A case of medullomyoblastoma. (21696510)
2011
5
Medullomyoblastoma: a medulloblastoma with rhabdomyoblastic differentiation]. (20451073)
2010
6
Medullomyoblastoma: teratoid nature of a quite rare neoplasm. (18261773)
2008
7
The role of immunohistochemistry in medullomyoblastoma--a case series highlighting divergent differentiation. (18439235)
2008
8
Cerebellar medullomyoblastoma with melanotic tubular structures. (16550533)
2008
9
Medullomyoblastoma with calcification: a case report. (18181837)
2008
10
Concurrent gain of 17q and the MYC oncogene in a medullomyoblastoma. (18021376)
2007
11
A 3 1/2-year-old child with a posterior fossa mass. Pigmented medullomyoblastoma. (16594755)
2006
12
Unusually long survival in a case of medullomyoblastoma. (16326277)
2005
13
A case of medullomyoblastoma of cerebellopontine angle mimicking acoustic neuroma. (15344215)
2004
14
Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literature. (15368333)
2004
15
Medullomyoblastoma: case report. (11510933)
2001
16
Ultrastructural changes in medullomyoblastoma. Similarities with foetal rhabdomyoma. (10514575)
1999
17
Medullomyoblastoma: A case report. (10339710)
1999
18
Medullomyoblastoma: a histological, immunohistochemical, ultrastructural and molecular genetic study. (9498058)
1998
19
Medullomyoblastoma. A rare cerebellar tumour in children. (9726581)
1998
20
Development of medullomyoblastoma from classical medulloblastoma following a long term latency. (8867688)
1995
21
Medullomyoblastoma: report of two cases. (1327526)
1992
22
Cerebellar medullomyoblastoma with advanced neuronal differentiation and hamartomatous component. (1662856)
1991
23
Medullomyoblastoma. (2290468)
1990
24
Medullomyoblastoma in an adult. (2403482)
1990
25
Medullomyoblastoma: immunohistochemical and ultrastructural study]. (2281954)
1990
26
Medullomyoblastoma. A case report. (2561483)
1989
27
Medullomyoblastoma: a case report. (2819571)
1989
28
Pigmented primitive neuroectodermal tumor with multipotential differentiation in cerebellum (pigmented medullomyoblastoma). A case with light- and electron-microscopic, and immunohistochemical analysis. (3136447)
1987
29
Medullomyoblastoma. A teratoma. (3978542)
1985
30
Medullomyoblastoma. A histologic, immunohistochemical, and ultrastructural study. (6202392)
1984
31
Ultrastructural study of medullomyoblastoma. (230690)
1979
32
Primary cerebral rhabdomyosarcoma and the problem of medullomyoblastoma. (5049814)
1972
33
Embryonal rhabdomyosarcoma of the middle ear primary to so-called medullomyoblastoma of brain. (5446604)
1970
34
A CASE OF MEDULLOMYOBLASTOMA. (14190997)
1963

Variations for Medullomyoblastoma

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Expression for genes affiliated with Medullomyoblastoma

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Search GEO for disease gene expression data for Medullomyoblastoma.

Pathways for genes affiliated with Medullomyoblastoma

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Pathways related to Medullomyoblastoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8MYC, MYCN
29.5GFAP, MYC, TP53
3
Show member pathways
9.2MYC, OTX2, TP53, TP63

GO Terms for genes affiliated with Medullomyoblastoma

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Biological processes related to Medullomyoblastoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of mesenchymal cell proliferationGO:000205310.3MYC, MYCN
2response to gamma radiationGO:001033210.1MYC, TP53
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.1TP53, TP63
4intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:004277110.0TP53, TP63
5positive regulation of muscle cell differentiationGO:005114910.0MYOD1, MYOG
6positive regulation of myoblast fusionGO:190174110.0MYOD1, MYOG
7myotube differentiationGO:001490210.0MYOD1, MYOG
8skeletal muscle fiber developmentGO:00487419.9MYOD1, MYOG
9positive regulation of transcription, DNA-templatedGO:00458938.5MYC, MYOD1, MYOG, OTX2, TP53, TP63
10regulation of transcription, DNA-templatedGO:00063557.7MYC, MYCN, MYOD1, MYOG, OTX2, TP53
11positive regulation of transcription from RNA polymerase II promoterGO:00459446.9MYC, MYCN, MYOD1, MYOG, OTX2, PPP1R12A

Molecular functions related to Medullomyoblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00010779.4MYC, MYOG, TP63
2transcription factor activity, sequence-specific DNA bindingGO:00037008.9MYOD1, MYOG, OTX2

Sources for Medullomyoblastoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet