Aliases & Classifications for Megacolon

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Aliases & Descriptions for Megacolon:

Name: Megacolon 11 13 37 66
Megacolon, Not Hirschsprung's 11 66
Megacolon Excluding Hirschsprung's Disease 11
 
Megacolon, Other Than Hirschsprung's 11
Dilatation of Colon 11
Megacolon Nos 11

Classifications:



External Ids:

Disease Ontology11 DOID:11372
ICD1028 K59.3
MeSH37 D008531
NCIt43 C34810

Summaries for Megacolon

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Wikipedia:69 Megacolon is an abnormal dilation of the colon (also called the large intestine). The dilation is often... more...

MalaCards based summary: Megacolon, also known as megacolon, not hirschsprung's, is related to hirschsprung disease 1 and shprintzen-goldberg syndrome, and has symptoms including constipation and vomiting following gastrointestinal surgery. An important gene associated with Megacolon is SOX10 (SRY-Box 10), and among its related pathways are Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) and Acetylcholine Synthesis. Affiliated tissues include colon, heart and smooth muscle, and related mouse phenotypes are embryo and limbs/digits/tail.

Disease Ontology:11 A colonic disease that is characterized by an abnormal dilation of the colon.

Related Diseases for Megacolon

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Diseases related to Megacolon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1hirschsprung disease 131.2EDN3, EDNRB, GDNF, PHOX2B, RET
2shprintzen-goldberg syndrome31.1EDN3, EDNRB, GDNF, RET
3toxic megacolon12.4
4goldberg-shprintzen megacolon syndrome12.3
5hirschsprung disease 211.2
6ulcerative colitis10.9
7colitis10.6
8splenic disease10.5DRD2, HTR2A
9waardenburg syndrome, type 110.4EDN3, SOX10
10motility-related diarrhea10.4FOXP3, VIP
11lipedematous scalp10.4DRD2, HTR2A
12herpes gestationis10.3DRD2, HTR2A
13hirschsprung nail hypoplasia dysmorphism10.3EDN3, EDNRB, SOX10
14siberian tick typhus10.3ACHE, CHAT
15placental insufficiency10.3EDNRB, RET, SOX10
16maternal uniparental disomy of chromosome 1310.3DRD2, HTR2A, SOX10
17conjunctival cancer10.3EDN3, EDNRB, SOX10
18constipation10.2
19megaesophagus10.2
20neuronitis10.2
21rectum leiomyosarcoma10.2EDNRB, FOXP3, RET
22crohn's disease10.1
23chagas disease10.1
24calabro syndrome10.1GDNF, RET
25kernicterus due to isoimmunization10.1DRD2, HTR2A
26clostridium difficile colitis10.1
27diabetes mellitus, noninsulin-dependent, 510.0EDN3, EDNRB, RET, SOX10
28homocystinuria9.9EDN3, EDNRB, RET, SOX10
29vascular cancer9.9DRD2, HTR2A
30piebaldism9.9
31crohn's colitis9.9
32myxedema9.9
33hypoganglionosis9.9
34cytomegalovirus infection9.9
35ileocolitis9.9GDNF, GFRA1
36hypogonadism cardiomyopathy9.9ACHE, GDNF, RET
37diarrhea9.9
38compartment syndrome9.9
39neurofibromatosis9.9
40multiple endocrine neoplasia9.9
41perineocele9.9GDNF, RET
42hirschsprung disease 69.8
43hirschsprung disease 99.8
44hirschsprung disease 39.8
45hirschsprung disease 59.8
46hirschsprung disease 89.8
47hirschsprung disease 79.8
48hirschsprung disease 49.8
49ifap syndrome with or without bresheck syndrome9.8
50autoimmune gastrointestinal dysmotility9.8

Comorbidity relations with Megacolon via Phenotypic Disease Network (PDN):


Deficiency AnemiaFamilial Atrial Fibrillation
Heart DiseaseIntestinal Obstruction
Intestinal VolvulusActive Peptic Ulcer Disease
Acute CystitisDecubitus Ulcer
Paralytic IleusParkinson Disease, Late-Onset
Protein-Energy MalnutritionSchizophreniform Disorder

Graphical network of the top 20 diseases related to Megacolon:



Diseases related to megacolon

Symptoms for Megacolon

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UMLS symptoms related to Megacolon:


constipation, vomiting following gastrointestinal surgery

Drugs & Therapeutics for Megacolon

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Drugs for Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
VancomycinPhase 4, Phase 2, Phase 33161404-90-6441141, 14969
Synonyms:
(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-Oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid
(2.2Sp,3.5sa,2.6sp)-O(4.2),C(3.4):c(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]
1404-90-6
1404-93-9 (hydrochloride)
64685-75-2 (sulfate)
AC1L24VU
AC1L9AMI
AC1Q29OH
BIDD:GT0353
C06689
C66H75Cl2N9O24
CHEBI:28001
CHEMBL262777
CID14969
CID441141
CID5311496
CID6426898
CID6917992
D00212
DB00512
EINECS 215-772-6
HSDB 3262
LMPK14000004
 
LS-161387
Lopac0_001267
MolPort-001-794-649
NCGC00162383-02
Prestwick0_000497
Prestwick1_000497
Prestwick2_000497
SPBio_002314
UNII-6Q205EH1VU
VAN
VANCOMYCIN
Vancocin
Vancocin (TN)
Vancocin HCL
Vancomicina
Vancomicina [INN-Spanish]
Vancomycin
Vancomycin (USP)
Vancomycin HCL
Vancomycin [USAN:INN:BAN]
Vancomycine
Vancomycine [INN-French]
Vancomycinum
Vancomycinum [INN-Latin]
nchembio.350-comp1
2
MetronidazolePhase 2, Phase 3438443-48-14173
Synonyms:
1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole
1-(β-ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(β-oxyethyl)-2-methyl-5-nitroimidazole
1-Hydroxyethyl-2-methyl-5-nitroimidazole
2-(2-methyl-5-nitroimidazol-1-yl)ethanol
2-Methyl-5-nitro-1-imidazoleethanol
2-Methyl-5-nitroimidazole-1-ethanol
2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole
2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole
2-methyl-5-nitroimidazole-1-ethanol
443-48-1
46461_FLUKA
46461_RIEDEL
69198-10-3 (mono-hydrochloride)
99616-64-5
AB00052046
AC-10556
AC1L1HKS
AC1Q2P2Z
AKOS000269646
APMN
ARONIS24285
Acromona
Anagiardil
Apo-Metronidazole
Arilin
Atrivyl
BAS 02983617
BAY-5360
BCBcMAP01_000184
BIDD:GT0107
BPBio1_000004
BRD-K52020312-001-05-2
BRN 0611683
BSPBio_000002
BSPBio_002031
Bayer 5360
Bexon
Bio-0694
CAS-443-48-1
CB-01-14 MMX
CCRIS 410
CHEBI:39845
CHEBI:6909
CHEMBL137
CID4173
CONT
CPD000058175
Caswell No. 579AA
Clont
D00409
DB00916
Danizol
Deflamon
Deflamon-wirkstoff
DivK1c_000007
EINECS 207-136-1
EPA Pesticide Chemical Code 120401
Efloran
Elyzol
Entizol
Eumin
FLAGYL I.V. RTU IN PLASTIC CONTAINER
Flagemona
Flagesol
Flagil
Flagyl
Flagyl (TN)
Flagyl 375
Flagyl Er
Flagyl I.V.
Flagyl I.V. RTU
Flegyl
Florazole
Fossyol
Giatricol
Ginefla vir
Gineflavir
HMS1568A04
HMS1920N19
HMS2051G07
HMS2090B19
HMS2091F14
HMS500A09
HMS547C19
HSDB 3129
I14-0667
IDI1_000007
IDR-90105
KBio1_000007
KBio2_001515
KBio2_004083
KBio2_006651
KBio3_001531
KBioGR_000559
KBioSS_001515
Klion
Klont
LS-1264
M0924
M1547_SIGMA
M3761_FLUKA
M3761_SIGMA
M9036_SIGMA
METRO I.V
METRONIDAZOLE USP
MLS000028590
MLS000758286
Maybridge1_001999
Meronidal
Methronidazole
Methyl-5-nitroimidazole-1-ethanol
 
Metric
Metric 21
Metro Cream
Metro Gel
Metro I.V.
Metro I.V. In Plastic Container
MetroCream
MetroGel
MetroGel-Vaginal
MetroLotion
Metrodzhil
Metrogel-vaginal (TN)
Metrogyl
Metrolag
Metrolyl
Metromidol
Metronidaz
Metronidazol
Metronidazol [INN-Spanish]
Metronidazole (JP15/USP/INN)
Metronidazole Benzoate
Metronidazole Monohydrochloride
Metronidazole Phosphoester
Metronidazole [USAN:INN:BAN:JAN]
Metronidazole in Plastic Container
Metronidazolo
Metronidazolo [DCIT]
Metronidazolum
Metronidazolum [INN-Latin]
Metrotop
Metrozine
Metryl
Mexibol
Mexibol 'silanes'
MolPort-000-141-892
MolPort-002-502-101
Monagyl
Monasin
NCGC00016446-01
NCGC00016446-02
NCGC00022059-03
NCGC00022059-04
NCGC00022059-05
NCIOpen2_000337
NIDA
NINDS_000007
NSC 50364
NSC 69587
NSC-50364
NSC50364
NSC69587
Nalox
Nidagel
Noritate
Noritate (TN)
Novonidazol
Orvagil
Prestwick0_000081
Prestwick1_000081
Prestwick2_000081
Prestwick3_000081
Prestwick_334
Protostat
RP 8823
RP-8823
Rathimed
Rosased
S1907_Selleck
SAM001247010
SBB041018
SC 10295
SMP1_000189
SMR000058175
SPBio_000666
SPBio_001941
SPECTRUM1500412
STK177359
Sanatrichom
Satric
Spectrum2_000883
Spectrum3_000506
Spectrum4_000060
Spectrum5_001289
Spectrum_001035
Takimetol
Trichazol
Trichex
Tricho cordes
Tricho-gynaedron
Trichocide
Trichomol
Trichomonacid 'pharmachim'
Trichopal
Trichopol
Tricocet
Tricom
Tricowas B
Trikacide
Trikamon
Trikojol
Trikozol
Trimeks
Trivazol
UNII-140QMO216E
Vagilen
Vagimid
Vandazole
Vertisal
WLN: T5N CNJ A2Q B1 ENW
WLN: T5N CNJA2Q B1 ENW
WLN: T6NTJ DQ ANU1- ET5N CNJ A1 BNW
Wagitran
ZERO/004064
ZINC00113442
Zadstat
Zidoval
giniflavir
metronidazole
neo-Tric
3
Pancrelipase91753608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
PA
 
Pancreatic alpha-amylase precursor
Pancrelipase (amylase
lipase
protease)
4
Lactulose924618-18-211333
Synonyms:
(2S,3R,4S,5R,6R)-2-[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
4-O-b-D-Galactopyranosyl-D-Fructofuranose
4-O-b-D-Galactopyranosyl-D-fructose
4-O-beta-D-Galactopyranosyl-D-Fructofuranose
4-O-beta-D-Galactopyranosyl-D-fructofuranose
4-O-beta-D-Galactopyranosyl-D-fructose
4-O-beta-delta-Galactopyranosyl-delta-Fructofuranose
4-O-beta-delta-Galactopyranosyl-delta-fructose
 
Bifiteral
Cephulac
D-Lactulose
Lactulosa
Lactulose
Lactulosum
delta-Lactulose
lactulosa
lactulosum
5pancreatin917
6COLANutraceuticalPhase 01824

Interventional clinical trials:

(show all 23)
idNameStatusNCT IDPhase
1Optimal Treatment for Recurrent Clostridium DifficileRecruitingNCT02667418Phase 4
2Probiotics for Prophylaxis of Postoperative Hirschsprungs Associated EnterocolitisRecruitingNCT02343562Phase 4
3Immunodeficiency in Cartilage-hair Hypoplasia: Sub-project on Safety of Vaccination Against ChickenpoxEnrolling by invitationNCT02383797Phase 4
4Intestinal Lavage for the Treatment of Severe C. Difficile InfectionsRecruitingNCT02466698Phase 2, Phase 3
5Probiotic Prophylaxis of Hirschprung's Disease Associated Enterocolitis (HAEC)CompletedNCT00630838Phase 2
6Endoscopic Mucosal Resection for the Diagnosis of a-Ganglionosis, a Controlled Prospective Trial (EDGE Trial)RecruitingNCT01515501Phase 2
7Endoscopic Mucosal Resection (EMR) for Diagnosis of Hirschsprung's DiseaseEnrolling by invitationNCT00671684Phase 1, Phase 2
8Host Immune Response to Clostridium Difficile Infection (ICD)CompletedNCT02440438
9A Trial on Conservative Treatment for Infants' Hirschsprung DiseaseCompletedNCT01985646Phase 0
10A Trial on Probiotics in Preventing Hirschsprung's Disease Associated EntercolitisCompletedNCT01934959Phase 0
11A Trial on Treatments of Hirschsprung Allied DiseaseRecruitingNCT02212054Phase 0
12Genetic Mosaicism in Hirschsprung's DiseaseRecruitingNCT01927809
13Abdominal SepsiS Study: Epidemiology of Etiology and OutcomeRecruitingNCT02442596
14Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated ColitisRecruitingNCT01959048
15MICROPRUNG : Intestinal Microbiota Analysis in Patients With or Without Hirschsprung's Associated EnteroColitisRecruitingNCT02857205
16Enhanced Recovery After Surgery In Hirschsprung DiseaseRecruitingNCT02776176
17Fast-track Surgery in the Treatment of Hirschsprung's DiseaseRecruitingNCT02350088
183D High Resolution Anorectal Manometry in Children After Surgery for Anorectal DisordersRecruitingNCT02296008
19Comparison of Circular(Soave) and Heart-shaped Anastomosis in Hirschsprung's Disease: A Prospective Multicenter Randomized Controlled TrialRecruitingNCT02234219
20A New Scoring System Improves Diagnostic Accuracy of Intestinal Dysganglionosis --a Prospective StudyRecruitingNCT02216994
21Identification Genetic, Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung DiseaseRecruitingNCT02193685
22Hirschsprung Disease Genetic StudyRecruitingNCT00478712
23Electrophysiological Activity of the Anorectum in Children Suspected of Hirschsprung DiseaseNot yet recruitingNCT02342457

Search NIH Clinical Center for Megacolon


Cochrane evidence based reviews: megacolon

Genetic Tests for Megacolon

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Anatomical Context for Megacolon

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MalaCards organs/tissues related to Megacolon:

34
Colon, Heart, Smooth muscle, Spinal cord, Bone, Bone marrow, Myeloid

Animal Models for Megacolon or affiliated genes

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MGI Mouse Phenotypes related to Megacolon:

39 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.6EDN3, EDNRB, GFRA1, PHOX2B, RET, SOX10
2MP:00053718.0CHAT, DRD2, EDNRB, FOXP3, RET, SOX10
3MP:00053917.8ACHE, CHAT, EDNRB, FOXP3, NRTN, PHOX2B
4MP:00053677.7DRD2, EDNRB, FOXP3, GDNF, GFRA1, RET
5MP:00053887.6ACHE, DRD2, EDNRB, FOXP3, PHOX2B, RET
6MP:00053857.4CHAT, DRD2, EDNRB, FOXP3, GDNF, PHOX2B
7MP:00028737.3CHAT, DRD2, FOXP3, GFRA1, PHOX2B, RET
8MP:00053697.1ACHE, CHAT, DRD2, EDNRB, GDNF, GFRA1
9MP:00053847.1DRD2, EDNRB, FOXP3, GDNF, GFRA1, PHOX2B
10MP:00053797.1DRD2, EDNRB, FOXP3, GDNF, HTR2A, NRTN
11MP:00053897.0ACHE, CHAT, DRD2, FOXP3, GDNF, NRTN
12MP:00053816.4CHAT, DRD2, EDN3, EDNRB, FOXP3, GDNF
13MP:00053786.3ACHE, CHAT, DRD2, EDNRB, FOXP3, GDNF
14MP:00036316.1ACHE, CHAT, DRD2, EDN3, EDNRB, GDNF
15MP:00107685.5ACHE, CHAT, DRD2, EDN3, EDNRB, FOXP3
16MP:00053864.7ACHE, CHAT, DRD2, EDN3, EDNRB, FOXP3

Publications for Megacolon

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Articles related to Megacolon:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
Enteric Neuronal Damage, Intramuscular Denervation and Smooth Muscle Phenotype Changes as Mechanisms of Chagasic Megacolon: Evidence from a Long-Term Murine Model of Tripanosoma cruzi Infection. (27045678)
2016
2
Trypanosomiasis-induced megacolon illustrates how myenteric neurons modulate the risk for colon cancer in rats and humans. (25884710)
2015
3
Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. (25866348)
2015
4
Clinical Features and Colonic Motor Disturbances in Chronic Megacolon in Adults. (25868630)
2015
5
Male-biased aganglionic megacolon in the TashT mouse line due to perturbation of silencer elements in a large gene desert of chromosome 10. (25786024)
2015
6
Is really megacolon a contraindication to infliximab in Crohn's disease? (24592552)
2013
7
Unusual Complication of Toxic Megacolon in Typhoid Colitis. (23900751)
2013
8
Reduced population of interstitial cells of Cajal in Chagasic megacolon. (23435133)
2012
9
Preponderance of inhibitory versus excitatory intramuscular nerve fibres in human chagasic megacolon. (22729712)
2012
10
Long-term follow up of abdominal rectosigmoidectomy with posterior end-to-side stapled anastomosis for Chagas megacolon. (19906053)
2011
11
Chagas disease in the differential diagnosis of megacolon. (22054277)
2011
12
Toxic megacolon due to fulminant Clostridium Difficile colitis. (21861326)
2011
13
CMV infection in a pregnant woman complicated by toxic megacolon and mesenteric vein thrombosis. (19821211)
2009
14
Toxic megacolon in children with inflammatory bowel disease: clinical and radiographic characteristics. (18510624)
2008
15
Invasive aspergillosis localised to the colon presenting as toxic megacolon. (17328784)
2007
16
Surgical treatment of Chagasic megacolon by abdominal rectosigmoidectomy with immediate posterior end-to-side stapling (Habr-Gama technique). (16897331)
2006
17
Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon. (16048580)
2005
18
Advances in the diagnosis and management of toxic megacolon. (15776138)
2005
19
Successful treatment of megacolon associated with colitis with a nitric oxide synthase inhibitor. (11467676)
2001
20
Cell-mediated immune response in megacolon from patients with chronic Chagas' disease. (11496080)
2001
21
Chagasic megacolon associated with colon cancer. (9230785)
1997
22
Refractory constipation and megacolon in MEN 2b. (8943978)
1996
23
Megacolon in rats. (2373271)
1990
24
Toxic megacolon and perforation caused by Shigella. (2688808)
1989
25
Toxic megacolon and perforation caused by Salmonella. (2765830)
1989
26
Function of the striated anal sphincter during straining in control subjects and constipated patients with a radiologically normal rectum or idiopathic megacolon. (3198990)
1988
27
Megaesophagus, megacolon and cancer. (3151134)
1988
28
Treatment of acute nontoxic megacolon during colonoscopy: tube placement versus simple decompression. (3350299)
1988
29
Idiopathic megacolon presenting with fatal inferior vena caval obstruction and colonic perforation. Case report. (3213371)
1988
30
Waardenburg syndrome, Hirschsprung megacolon, and Marcus Gunn ptosis. (3631139)
1987
31
Pathology: rectal suction biopsy in the diagnosis of congenital megacolon. (18750075)
1986
32
Toxic megacolon due to Campylobacter colitis. (3598315)
1986
33
Megacolon in adults. (4041749)
1985
34
Funnel anus and megacolon in an adult. (4064858)
1985
35
Toxic megacolon in typhoid fever. (4062466)
1985
36
Computerized tomographic demonstration of toxic megacolon: report of a case. (6641190)
1983
37
Intracolonic formation of struvite crystals in a patient with congenital megacolon. (6976282)
1982
38
Observations on the immunocytes and macrophages in megacolon. (7044725)
1982
39
Sigmoid volvulus with and without megacolon. (7128369)
1982
40
Clostridium difficile in toxic megacolon. (6814650)
1982
41
Toxic megacolon. Part I: Pathogenesis, diagnosis and treatment. (6265121)
1981
42
Lower oesophageal sphincter response to pentagastrin in chagasic patients with megaoesophagus and megacolon. (6769753)
1980
43
An assessment of anorectal motility in the management of adult megacolon. (7427031)
1980
44
Partial colectomy in the treatment of recurrent obstipation/megacolon in the cat. (250327)
1978
45
Hirschsprung's disease, aganglionic or hypoganglionic megacolon. Animal model: aganglionic megacolon in piebald and spotted mutant mouse strains. (1124798)
1975
46
Radiographic evaluation of toxic megacolon in acute ulcerative colitis. (4484006)
1972
47
Toxic megacolon. A surgical disease. (5546331)
1971
48
Surgical treatment of toxic megacolon. Ileostomy and colostomy to prepare patients for colectomy. (5570601)
1971
49
Non-tropical sprue as a cause of megacolon. Report of a case. (5492579)
1970
50
TOXIC MEGACOLON COMPLICATING CHRONIC ULCERATIVE COLITIS. (14315434)
1965

Variations for Megacolon

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Expression for genes affiliated with Megacolon

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Search GEO for disease gene expression data for Megacolon.

Pathways for genes affiliated with Megacolon

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GO Terms for genes affiliated with Megacolon

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Cellular components related to Megacolon according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304248.7DRD2, HTR2A, NRTN, RET
2intracellularGO:00056228.1EDN3, FOXP3, GDNF, GFRA1, NRTN

Biological processes related to Megacolon according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1vein smooth muscle contractionGO:001482610.8EDN3, EDNRB
2posterior midgut developmentGO:000749710.7EDNRB, RET
3vasoconstrictionGO:004231010.6EDN3, EDNRB
4response to painGO:004826510.5EDNRB, RET
5mRNA stabilizationGO:004825510.4GDNF, VIP
6artery smooth muscle contractionGO:001482410.4EDN3, HTR2A
7sympathetic nervous system developmentGO:004848510.4GDNF, PHOX2B
8melanocyte differentiationGO:003031810.4EDN3, EDNRB, SOX10
9negative regulation of potassium ion transportGO:004326710.4HTR2A, VIP
10developmental pigmentationGO:004806610.4EDNRB, ZEB2
11peripheral nervous system developmentGO:000742210.2EDNRB, GDNF, SOX10
12phosphatidylcholine biosynthetic processGO:000665610.2ACHE, CHAT
13positive regulation of penile erectionGO:00604069.9EDNRB, VIP
14positive regulation of neuroblast proliferationGO:00020529.8DRD2, SOX10
15enteric nervous system developmentGO:00484849.7EDNRB, GDNF, PHOX2B, RET, SOX10
16positive regulation of urine volumeGO:00358109.7DRD2, EDNRB
17neuron differentiationGO:00301829.6EDN3, PHOX2B, RET
18peristalsisGO:00304329.6DRD2, GDNF
19positive regulation of renal sodium excretionGO:00358159.6DRD2, EDNRB
20temperature homeostasisGO:00016599.6DRD2, HTR2A
21regulation of dopamine uptake involved in synaptic transmissionGO:00515849.5DRD2, GDNF
22MAPK cascadeGO:00001659.5GDNF, GFRA1, NRTN, RET
23negative regulation of synaptic transmission, glutamatergicGO:00519679.5DRD2, HTR2A
24regulation of dopamine secretionGO:00140599.5DRD2, HTR2A
25negative regulation of adenylate cyclase activityGO:00071949.4DRD2, EDNRB
26behavioral response to cocaineGO:00481489.3DRD2, HTR2A
27neural crest cell migrationGO:00017559.1EDN3, EDNRB, GDNF, NRTN, RET, SOX10
28positive regulation of cell proliferationGO:00082849.0EDN3, EDNRB, GDNF, HTR2A, VIP
29response to drugGO:00424938.9CHAT, DRD2, HTR2A, RET
30positive regulation of transcription from RNA polymerase II promoterGO:00459447.8DRD2, FOXP3, GDNF, PHOX2B, SOX10, ZEB2
31nervous system developmentGO:00073997.6ACHE, EDNRB, GDNF, GFRA1, NRTN, RET

Molecular functions related to Megacolon according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Ras guanyl-nucleotide exchange factor activityGO:00050889.2GDNF, GFRA1, NRTN, RET
2receptor bindingGO:00051028.2DRD2, EDN3, GDNF, GFRA1, NRTN

Sources for Megacolon

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet