MCID: MGC001
MIFTS: 45

Megacolon malady

Gastrointestinal diseases category

Aliases & Classifications for Megacolon

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Aliases & Descriptions for Megacolon:

Name: Megacolon 10 12 65 36
Megacolon, Not Hirschsprung's 10 65
Megacolon Excluding Hirschsprung's Disease 10
 
Megacolon, Other Than Hirschsprung's 10
Dilatation of Colon 10
Megacolon Nos 10


Classifications:



External Ids:

Disease Ontology10 DOID:11372
NCIt42 C34810
MeSH36 D008531
ICD1027 K59.3

Summaries for Megacolon

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Wikipedia:68 Megacolon is an abnormal dilation of the colon (also called the large intestine). The dilation is often... more...

MalaCards based summary: Megacolon, also known as megacolon, not hirschsprung's, is related to waardenburg syndrome, type 1 and multiple endocrine neoplasia iia. An important gene associated with Megacolon is SOX10 (SRY (Sex Determining Region Y)-Box 10), and among its related pathways are Biogenic Amine Synthesis and Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction). Affiliated tissues include colon, bone and smooth muscle, and related mouse phenotypes are pigmentation and digestive/alimentary.

Disease Ontology:10 A colonic disease that is characterized by an abnormal dilation of the colon.

Related Diseases for Megacolon

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Diseases related to Megacolon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1waardenburg syndrome, type 130.3EDN3, SOX10
2multiple endocrine neoplasia iia30.2EDNRB, GDNF, RET
3multiple endocrine neoplasia iib29.9EDNRB, GDNF, RET
4central hypoventilation syndrome, congenital29.7EDN3, EDNRB, GDNF, PHOX2B, RET
5pheochromocytoma29.6GDNF, RET, VIP
6intestinal perforation29.4ACHE, EDN3, EDNRB, GDNF, NRTN, RET
7hirschsprung disease 128.1ACHE, ECE1, EDN3, EDNRB, GDNF, KIF1BP
8toxic megacolon11.1
9colitis10.9
10ulcerative colitis10.7
11goldberg-shprintzen megacolon syndrome10.5
12megaesophagus10.5
13constipation10.5
14crohn's disease10.4
15chagas disease10.4
16neuronitis10.4
17clostridium difficile colitis10.3
18piebaldism10.3
19mowat-wilson syndrome10.2
20ifap syndrome with or without bresheck syndrome10.2
21myxedema10.2
22crohn's colitis10.2
23hypoganglionosis10.2
24cytomegalovirus infection10.2
25visceral myopathy10.1
26smith-lemli-opitz syndrome10.1
27hirschsprung disease 210.1
28mckusick-kaufman syndrome10.1
29pcwh syndrome10.1
30cerebral creatine deficiency syndrome 110.1
31neurofibromatosis10.1
32compartment syndrome10.1
33hirschsprung disease type d brachydactyly10.1
34ring chromosome 1010.1
35conjunctival intraepithelial neoplasm10.1EDN3, EDNRB, SOX10
36birdshot chorioretinopathy10.1ACHE, VIP
37ornithosis10.1GDNF, RET
38nontoxic goiter10.1NRG1, RET
39intracortical osteogenic sarcoma10.0L1CAM, SOX10
40colonic atresia10.0
41cartilage-hair hypoplasia10.0
42hirschsprung disease 510.0
43joubert syndrome 110.0
44rubinstein-taybi syndrome10.0
45fanconi anemia, complementation group a10.0
46duane-radial ray syndrome10.0
47velocardiofacial syndrome10.0
48metachromatic leukodystrophy10.0
49masa syndrome10.0
50corpus callosum, partial agenesis of10.0

Graphical network of the top 20 diseases related to Megacolon:



Diseases related to megacolon

Symptoms for Megacolon

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Drugs & Therapeutics for Megacolon

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Drugs for Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
VancomycinapprovedPhase 2, Phase 32861404-90-6441141, 14969
Synonyms:
(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-Oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid
(2.2Sp,3.5sa,2.6sp)-O(4.2),C(3.4):c(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]
1404-90-6
1404-93-9 (hydrochloride)
64685-75-2 (sulfate)
AC1L24VU
AC1L9AMI
AC1Q29OH
BIDD:GT0353
C06689
C66H75Cl2N9O24
CHEBI:28001
CHEMBL262777
CID14969
CID441141
CID5311496
CID6426898
CID6917992
D00212
DB00512
EINECS 215-772-6
HSDB 3262
LMPK14000004
LS-161387
 
Lopac0_001267
MolPort-001-794-649
NCGC00162383-02
Prestwick0_000497
Prestwick1_000497
Prestwick2_000497
SPBio_002314
UNII-6Q205EH1VU
VAN
VANCOMYCIN
Vancocin
Vancocin (TN)
Vancocin HCL
Vancomicina
Vancomicina [INN-Spanish]
Vancomycin
Vancomycin (USP)
Vancomycin HCL
Vancomycin Hydrochloride
Vancomycin [USAN:INN:BAN]
Vancomycine
Vancomycine [INN-French]
Vancomycinum
Vancomycinum [INN-Latin]
nchembio.350-comp1
2
MetronidazoleapprovedPhase 2, Phase 3389443-48-14173
Synonyms:
1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole
1-(β-ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(β-oxyethyl)-2-methyl-5-nitroimidazole
1-Hydroxyethyl-2-methyl-5-nitroimidazole
2-(2-methyl-5-nitroimidazol-1-yl)ethanol
2-Methyl-5-nitro-1-imidazoleethanol
2-Methyl-5-nitroimidazole-1-ethanol
2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole
2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole
2-methyl-5-nitroimidazole-1-ethanol
443-48-1
46461_FLUKA
46461_RIEDEL
69198-10-3 (mono-hydrochloride)
99616-64-5
AB00052046
AC-10556
AC1L1HKS
AC1Q2P2Z
AKOS000269646
APMN
ARONIS24285
Acromona
Anagiardil
Apo-Metronidazole
Arilin
Atrivyl
BAS 02983617
BAY-5360
BCBcMAP01_000184
BIDD:GT0107
BPBio1_000004
BRD-K52020312-001-05-2
BRN 0611683
BSPBio_000002
BSPBio_002031
Bayer 5360
Bexon
Bio-0694
CAS-443-48-1
CB-01-14 MMX
CCRIS 410
CHEBI:39845
CHEBI:6909
CHEMBL137
CID4173
CONT
CPD000058175
Caswell No. 579AA
Clont
D00409
DB00916
Danizol
Deflamon
Deflamon-wirkstoff
DivK1c_000007
EINECS 207-136-1
EPA Pesticide Chemical Code 120401
Efloran
Elyzol
Entizol
Eumin
FLAGYL I.V. RTU IN PLASTIC CONTAINER
Flagemona
Flagesol
Flagil
Flagyl
Flagyl (TN)
Flagyl 375
Flagyl Er
Flagyl I.V.
Flagyl I.V. RTU
Flegyl
Florazole
Fossyol
Giatricol
Ginefla vir
Gineflavir
HMS1568A04
HMS1920N19
HMS2051G07
HMS2090B19
HMS2091F14
HMS500A09
HMS547C19
HSDB 3129
I14-0667
IDI1_000007
IDR-90105
KBio1_000007
KBio2_001515
KBio2_004083
KBio2_006651
KBio3_001531
KBioGR_000559
KBioSS_001515
Klion
Klont
LS-1264
M0924
M1547_SIGMA
M3761_FLUKA
M3761_SIGMA
M9036_SIGMA
METRO I.V
METRONIDAZOLE USP
MLS000028590
MLS000758286
Maybridge1_001999
Meronidal
Methronidazole
Methyl-5-nitroimidazole-1-ethanol
Metric
Metric 21
Metro Cream
Metro Gel
 
Metro I.V.
Metro I.V. In Plastic Container
MetroCream
MetroGel
MetroGel-Vaginal
MetroLotion
Metrocream
Metrodzhil
Metrogel
Metrogel-vaginal
Metrogel-vaginal (TN)
Metrogyl
Metrolag
Metrolotion
Metrolyl
Metromidol
Metronidaz
Metronidazol
Metronidazol [INN-Spanish]
Metronidazole
Metronidazole (JP15/USP/INN)
Metronidazole Benzoate
Metronidazole Monohydrochloride
Metronidazole Phosphoester
Metronidazole Topical Gel
Metronidazole [USAN:INN:BAN:JAN]
Metronidazole hydrochloride
Metronidazole in Plastic Container
Metronidazolo
Metronidazolo [DCIT]
Metronidazolum
Metronidazolum [INN-Latin]
Metrotop
Metrozine
Metryl
Mexibol
Mexibol 'silanes'
MolPort-000-141-892
MolPort-002-502-101
Monagyl
Monasin
NCGC00016446-01
NCGC00016446-02
NCGC00022059-03
NCGC00022059-04
NCGC00022059-05
NCIOpen2_000337
NIDA
NINDS_000007
NSC 50364
NSC 69587
NSC-50364
NSC50364
NSC69587
Nalox
Nidagel
Noritate
Noritate (TN)
Novonidazol
Orvagil
Prestwick0_000081
Prestwick1_000081
Prestwick2_000081
Prestwick3_000081
Prestwick_334
Protostat
RP 8823
RP-8823
Rathimed
Rosadan
Rosased
S1907_Selleck
SAM001247010
SBB041018
SC 10295
SMP1_000189
SMR000058175
SPBio_000666
SPBio_001941
SPECTRUM1500412
STK177359
Sanatrichom
Satric
Spectrum2_000883
Spectrum3_000506
Spectrum4_000060
Spectrum5_001289
Spectrum_001035
Takimetol
Trichazol
Trichex
Tricho cordes
Tricho-gynaedron
Trichocide
Trichomol
Trichomonacid 'pharmachim'
Trichopal
Trichopol
Tricocet
Tricom
Tricowas B
Trikacide
Trikamon
Trikojol
Trikozol
Trimeks
Trivazol
UNII-140QMO216E
Vagilen
Vagimid
Vandazole
Vertisal
WLN: T5N CNJ A2Q B1 ENW
WLN: T5N CNJA2Q B1 ENW
WLN: T6NTJ DQ ANU1- ET5N CNJ A1 BNW
Wagitran
ZERO/004064
ZINC00113442
Zadstat
Zidoval
giniflavir
metronidazole
neo-Tric
3
Lactuloseapproved894618-18-211333
Synonyms:
(2S,3R,4S,5R,6R)-2-[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
4-O-b-D-Galactopyranosyl-D-Fructofuranose
4-O-b-D-Galactopyranosyl-D-fructose
4-O-beta-D-Galactopyranosyl-D-Fructofuranose
4-O-beta-D-Galactopyranosyl-D-fructofuranose
4-O-beta-D-Galactopyranosyl-D-fructose
4-O-beta-delta-Galactopyranosyl-delta-Fructofuranose
4-O-beta-delta-Galactopyranosyl-delta-fructose
Bifiteral
Cephulac
 
Constulose
D-Lactulose
Enulose
Generlac
Kristalose
Lactulosa
Lactulose
Lactulosum
delta-Lactulose
lactulosa
lactulosum
4
Pancrelipaseapproved83953608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
Creon
PA
Pancreatic alpha-amylase precursor
Pancreaze
 
Pancrelipase
Pertzye
Polocaine-mpf
Ultresa
Viokace
Zenpep
5pancreatin839
6ColaNutraceuticalPhase 01690

Interventional clinical trials:

(show all 21)
idNameStatusNCT IDPhase
1Optimal Treatment for Recurrent Clostridium DifficileRecruitingNCT02667418Phase 4
2Probiotics for Prophylaxis of Postoperative Hirschsprungs Associated EnterocolitisRecruitingNCT02343562Phase 4
3Immunodeficiency in Cartilage-hair Hypoplasia: Sub-project on Safety of Vaccination Against ChickenpoxEnrolling by invitationNCT02383797Phase 4
4Intestinal Lavage for the Treatment of Severe C. Difficile InfectionsNot yet recruitingNCT02466698Phase 2, Phase 3
5Probiotic Prophylaxis of Hirschprung's Disease Associated Enterocolitis (HAEC)CompletedNCT00630838Phase 2
6Endoscopic Mucosal Resection for the Diagnosis of a-Ganglionosis, a Controlled Prospective Trial (EDGE Trial)RecruitingNCT01515501Phase 2
7Endoscopic Mucosal Resection (EMR) for Diagnosis of Hirschsprung's DiseaseEnrolling by invitationNCT00671684Phase 1, Phase 2
8A Trial on Conservative Treatment for Infants' Hirschsprung DiseaseCompletedNCT01985646Phase 0
9A Trial on Probiotics in Preventing Hirschsprung's Disease Associated EntercolitisCompletedNCT01934959Phase 0
10A Trial on Treatments of Hirschsprung Allied DiseaseRecruitingNCT02212054Phase 0
11Genetic Mosaicism in Hirschsprung's DiseaseRecruitingNCT01927809
12Abdominal SepsiS Study: Epidemiology of Etiology and OutcomeRecruitingNCT02442596
13Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated ColitisRecruitingNCT01959048
14Host Immune Response to Clostridium Difficile InfectionRecruitingNCT02440438
15Fast-track Surgery in the Treatment of Hirschsprung's DiseaseRecruitingNCT02350088
163D High Resolution Anorectal Manometry in Children After Surgery for Anorectal DisordersRecruitingNCT02296008
17Comparison of Circular(Soave) and Heart-shaped Anastomosis in Hirschsprung's Disease: A Prospective Multicenter Randomized Controlled TrialRecruitingNCT02234219
18A New Scoring System Improves Diagnostic Accuracy of Intestinal Dysganglionosis --a Prospective StudyRecruitingNCT02216994
19Identification Genetic, Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung DiseaseRecruitingNCT02193685
20Hirschsprung Disease Genetic StudyRecruitingNCT00478712
21Electrophysiological Activity of the Anorectum in Children Suspected of Hirschsprung DiseaseNot yet recruitingNCT02342457

Search NIH Clinical Center for Megacolon


Cochrane evidence based reviews: Megacolon

Genetic Tests for Megacolon

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Anatomical Context for Megacolon

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MalaCards organs/tissues related to Megacolon:

33
Colon, Bone, Smooth muscle, Bone marrow, Spinal cord, Myeloid, Skin

Animal Models for Megacolon or affiliated genes

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MGI Mouse Phenotypes related to Megacolon:

38 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.2ECE1, EDN3, EDNRB, L1CAM, SOX10
2MP:00053818.9ECE1, EDN3, EDNRB, GDNF, NRTN, RET
3MP:00053828.5ACHE, ECE1, EDNRB, L1CAM, SOX10, ZEB2
4MP:00053798.3ECE1, GDNF, NRG1, NRTN, RET, SOX10
5MP:00053888.2ACHE, EDNRB, NRG1, PHOX2B, RET, SOX10
6MP:00053808.1ECE1, EDN3, EDNRB, NRG1, PHOX2B, RET
7MP:00053698.0ACHE, CHAT, ECE1, EDNRB, GDNF, NRG1
8MP:00053858.0CHAT, ECE1, EDNRB, GDNF, NRG1, PHOX2B
9MP:00053917.3ACHE, ECE1, EDNRB, L1CAM, NRG1, NRTN
10MP:00053767.1ACHE, CHAT, ECE1, EDNRB, NRG1, PHOX2B
11MP:00053786.9ACHE, CHAT, EDNRB, GDNF, L1CAM, NRG1
12MP:00053896.8ACHE, CHAT, GDNF, L1CAM, NRG1, NRTN
13MP:00053866.3ACHE, CHAT, EDN3, EDNRB, GDNF, L1CAM
14MP:00036315.7ACHE, CHAT, ECE1, EDN3, EDNRB, GDNF
15MP:00107685.1ACHE, CHAT, ECE1, EDN3, EDNRB, GDNF

Publications for Megacolon

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Articles related to Megacolon:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Trypanosomiasis-induced megacolon illustrates how myenteric neurons modulate the risk for colon cancer in rats and humans. (25884710)
2015
2
Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. (25866348)
2015
3
Clinical Features and Colonic Motor Disturbances in Chronic Megacolon in Adults. (25868630)
2015
4
The KIT gene is associated with the english spotting coat color locus and congenital megacolon in Checkered Giant rabbits (Oryctolagus cuniculus). (24736498)
2014
5
Histopathologic findings in patients with idiopathic megacolon: a comparison between dilated and non-dilated loops. (24387755)
2014
6
Is really megacolon a contraindication to infliximab in Crohn's disease? (24592552)
2013
7
Reduced population of interstitial cells of Cajal in Chagasic megacolon. (23435133)
2012
8
Acute colonic pseudo-obstruction in acromegalic patient with dolicho-megacolon mimicking colonic volvulus. (22798128)
2012
9
Preponderance of inhibitory versus excitatory intramuscular nerve fibres in human chagasic megacolon. (22729712)
2012
10
Long-term follow up of abdominal rectosigmoidectomy with posterior end-to-side stapled anastomosis for Chagas megacolon. (19906053)
2011
11
Megacolon from Chagas disease in an ancient Texan. Diagnosis: Chagas disease causing mega-disease, in this case megacolon. (21640110)
2011
12
Megacystis, megacolon, and malrotation: a new syndromic association? (21739599)
2011
13
Chagasic megacolon associated with Trypanosoma cruzi I in a Colombian patient. (20502919)
2010
14
CMV infection in a pregnant woman complicated by toxic megacolon and mesenteric vein thrombosis. (19821211)
2009
15
Expression of caspase-3 in enteric cells is related to development of chagasic megacolon. (19289186)
2009
16
Morbidity and mortality assessment of modified Duhamel operation with immediate mechanical end-to-side colorectal anastomosis for chagasic megacolon: the role of the diverting stoma. (17394005)
2008
17
Toxic megacolon in children with inflammatory bowel disease: clinical and radiographic characteristics. (18510624)
2008
18
The enteric nervous system in chagasic and idiopathic megacolon. (17325489)
2007
19
Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon. (16048580)
2005
20
Advances in the diagnosis and management of toxic megacolon. (15776138)
2005
21
Congenital megacolon: diagnosis using size of sub-mucosal nerve trunk as a criteria. (12081127)
2002
22
Megacolon in pigs due to segmental colon aganglionosis. (11449915)
2001
23
Successful treatment of megacolon associated with colitis with a nitric oxide synthase inhibitor. (11467676)
2001
24
Sub-total colectomy for perforated toxic megacolon in pregnancy. (15512196)
1998
25
Sciatica as a manifestation of idiopathic megacolon: a previously undescribed causal relationship. (9738732)
1998
26
Megacolon in cats. The role of colectomy. (8503161)
1993
27
Surgery of chagasic megacolon. (1903231)
1991
28
Toxic megacolon and perforation caused by Salmonella. (2302504)
1990
29
Megacolon in rats. (2373271)
1990
30
Toxic megacolon and perforation caused by Shigella. (2688808)
1989
31
Megaesophagus, megacolon and cancer. (3151134)
1988
32
Waardenburg syndrome, Hirschsprung megacolon, and Marcus Gunn ptosis. (3631139)
1987
33
Megacolon in Zimbabwe: is there a new idiopathic variety? A preliminary report. (3792253)
1986
34
Toxic megacolon complicating Campylobacter enterocolitis. (3734370)
1986
35
Megacolon in adults. (4041749)
1985
36
Funnel anus and megacolon in an adult. (4064858)
1985
37
Toxic megacolon in typhoid fever. (4062466)
1985
38
Intracolonic formation of struvite crystals in a patient with congenital megacolon. (6976282)
1982
39
Observations on the immunocytes and macrophages in megacolon. (7044725)
1982
40
Toxic megacolon. Part I: Pathogenesis, diagnosis and treatment. (6265121)
1981
41
An assessment of anorectal motility in the management of adult megacolon. (7427031)
1980
42
Toxic megacolon--unusual complication of pseudomembranous colitis. (589788)
1977
43
Diagnosis, surgical management and prognosis of toxic megacolon, a complication of ulcerative colitis. (866982)
1977
44
Acquired aganglionic megacolon in a premature infant: report of a case. (1172231)
1975
45
Hirschsprung's disease, aganglionic or hypoganglionic megacolon. Animal model: aganglionic megacolon in piebald and spotted mutant mouse strains. (1124798)
1975
46
Electrical activity of the intestine of mice with hereditary megacolon and absence of enteric ganglion cells. (4705095)
1973
47
Diagnosis of congenital megacolon: an analysis of 501 patients. (4752993)
1973
48
Radiographic evaluation of toxic megacolon in acute ulcerative colitis. (4484006)
1972
49
Toxic megacolon. A surgical disease. (5546331)
1971
50
Non-tropical sprue as a cause of megacolon. Report of a case. (5492579)
1970

Variations for Megacolon

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Expression for genes affiliated with Megacolon

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Search GEO for disease gene expression data for Megacolon.

Pathways for genes affiliated with Megacolon

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Pathways related to Megacolon according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6ACHE, CHAT
29.6ACHE, CHAT
39.6ACHE, CHAT
48.9CHAT, ECE1, PHOX2B, RET

GO Terms for genes affiliated with Megacolon

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Biological processes related to Megacolon according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1posterior midgut developmentGO:000749710.7EDNRB, RET
2vein smooth muscle contractionGO:001482610.6EDN3, EDNRB
3positive regulation of penile erectionGO:006040610.5EDNRB, VIP
4vasoconstrictionGO:004231010.5EDN3, EDNRB
5mRNA stabilizationGO:004825510.4GDNF, VIP
6regulation of sensory perception of painGO:005193010.4EDNRB, VIP
7developmental pigmentationGO:004806610.4EDNRB, ZEB2
8regulation of systemic arterial blood pressure by endothelinGO:000310010.3ECE1, EDN3
9oligodendrocyte differentiationGO:004870910.3NRG1, SOX10
10response to painGO:004826510.3EDNRB, RET
11regulation of vasoconstrictionGO:001922910.2ECE1, EDN3
12sympathetic nervous system developmentGO:004848510.2GDNF, PHOX2B
13melanocyte differentiationGO:003031810.1EDN3, EDNRB, SOX10
14phosphatidylcholine biosynthetic processGO:000665610.0ACHE, CHAT
15positive regulation of axon extensionGO:004577310.0L1CAM, NRG1
16glial cell differentiationGO:00100019.9NRG1, PHOX2B
17neurotransmitter biosynthetic processGO:00421369.8ACHE, CHAT
18peripheral nervous system developmentGO:00074229.8EDNRB, GDNF, NRG1, SOX10
19transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.7NRG1, NRTN, RET
20enteric nervous system developmentGO:00484849.5EDNRB, GDNF, PHOX2B, RET, SOX10
21neuron differentiationGO:00301829.5EDN3, PHOX2B, RET
22neural crest cell migrationGO:00017559.0EDN3, EDNRB, GDNF, NRTN, RET, SOX10
23neuron projection developmentGO:00311759.0GDNF, L1CAM, NRTN
24nervous system developmentGO:00073996.7ACHE, EDNRB, GDNF, KIF1BP, L1CAM, NRG1

Molecular functions related to Megacolon according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone bindingGO:001704610.1ECE1, EDNRB
2growth factor activityGO:00080839.7GDNF, NRG1, NRTN
3receptor bindingGO:00051029.0EDN3, GDNF, NRG1, NRTN, VIP

Sources for Megacolon

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet