MCID: MGC001
MIFTS: 51

Megacolon malady

Gastrointestinal diseases category

Summaries for Megacolon

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Wikipedia:63 Megacolon is an abnormal dilation of the colon (a part of the large intestine). The dilation is often... more...

MalaCards based summary: Megacolon, also known as megacolon, not hirschsprung's, is related to toxic megacolon and constipation. An important gene associated with Megacolon is SOX10 (SRY (sex determining region Y)-box 10), and among its related pathways is Gastrin-CREB signalling pathway via PKC and MAPK. The compounds cinanserin and clotiapine have been mentioned in the context of this disorder. Affiliated tissues include colon, smooth muscle and bone marrow, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Disease Ontology:9 A colonic disease that is characterized by an abnormal dilation of the colon.

Aliases & Classifications for Megacolon

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Megacolon, Aliases & Descriptions:

Name: Megacolon 9 11 60
Megacolon, Not Hirschsprung's 9 60
Megacolon Excluding Hirschsprung's Disease 9
 
Megacolon, Other Than Hirschsprung's 9
Dilatation of Colon 9
Megacolon Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:11372
NCIt38 C34810
MeSH33 D008531
ICD1025 K59.3

Related Diseases for Megacolon

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Diseases related to Megacolon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 192)
idRelated DiseaseScoreTop Affiliating Genes
1toxic megacolon32.2FLOT2, TMC1
2constipation31.4VIP
3waardenburg's syndrome30.5EDNRB, SOX10
4multiple endocrine neoplasia30.3GAST, VIP
5intestinal pseudo-obstruction30.2ACHE
6hirschsprung disease 130.0EDNRB, BLVRB, SOX10, VIP, ACHE, NRTN
7neuroendocrine tumor29.9GAST, DRD2, VIP
8pheochromocytoma29.8DRD2, VIP, EDNRB
9achalasia29.7BLVRB, VIP, ACHE, GAST
10colitis10.8
11ulcerative colitis10.7
12goldberg-shprintzen megacolon syndrome10.5
13huntington disease10.4DRD2
14megaesophagus10.4
15pathological gambling10.4DRD2
16intestinal obstruction10.4EDNRB
17neuroleptic malignant syndrome10.4DRD2
18crohn's disease10.4
19neuronitis10.4
20chagas disease10.4
21waardenburg syndrome type 410.4EDNRB, SOX10
22impotence10.3EDNRB, VIP
23islet cell tumor10.3GAST, VIP
24endocrine gland cancer10.3VIP, GAST
25somatostatinoma10.3VIP, GAST
26piebaldism10.3
27clostridium difficile colitis10.3
28vipoma10.3VIP, GAST
29glucagonoma10.3VIP, GAST
30pyloric stenosis10.2GAST, BLVRB
31hyperprolactinemia10.2VIP, DRD2
32sensorineural hearing loss10.2SOX10, TMC1, EDNRB
33gastrinoma10.2VIP, GAST
34central hypoventilation syndrome, congenital10.2
35binswanger's disease10.2VIP, ACHE
36mowat-wilson syndrome10.2
37crohn's colitis10.2
38myxedema10.2
39hypoganglionosis10.2
40cytomegalovirus infection10.2
41inflammatory bowel disease10.2
42bipolar disorder10.1HTR2A, DRD2
43movement disease10.1NRTN, DRD2
44antisocial personality disorder10.1HTR2A, DRD2
45gilles de la tourette syndrome10.1HTR2A, DRD2
46visceral myopathy10.1
47smith-lemli-opitz syndrome10.1
48mckusick-kaufman syndrome10.1
49cerebral creatine deficiency syndrome 110.1
50multiple endocrine neoplasia iia10.1

Graphical network of the top 20 diseases related to Megacolon:



Diseases related to megacolon

Symptoms for Megacolon

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Drugs & Therapeutics for Megacolon

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Drug clinical trials:

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Search NIH Clinical Center for Megacolon

Genetic Tests for Megacolon

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Anatomical Context for Megacolon

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MalaCards organs/tissues related to Megacolon:

31
Colon, Smooth muscle, Bone marrow, Bone, Lymph node, Spinal cord, Heart, Lung, Skin, Myeloid

Animal Models for Megacolon or affiliated genes

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Publications for Megacolon

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Articles related to Megacolon:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Trypanosomiasis-induced megacolon illustrates how myenteric neurons modulate the risk for colon cancer in rats and humans. (25884710)
2015
2
Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. (25866348)
2015
3
The KIT gene is associated with the english spotting coat color locus and congenital megacolon in Checkered Giant rabbits (Oryctolagus cuniculus). (24736498)
2014
4
Histopathologic findings in patients with idiopathic megacolon: a comparison between dilated and non-dilated loops. (24387755)
2014
5
Is really megacolon a contraindication to infliximab in Crohn's disease? (24592552)
2013
6
Reduced population of interstitial cells of Cajal in Chagasic megacolon. (23435133)
2012
7
Acute colonic pseudo-obstruction in acromegalic patient with dolicho-megacolon mimicking colonic volvulus. (22798128)
2012
8
Preponderance of inhibitory versus excitatory intramuscular nerve fibres in human chagasic megacolon. (22729712)
2012
9
Long-term follow up of abdominal rectosigmoidectomy with posterior end-to-side stapled anastomosis for Chagas megacolon. (19906053)
2011
10
Megacolon from Chagas disease in an ancient Texan. Diagnosis: Chagas disease causing mega-disease, in this case megacolon. (21640110)
2011
11
Megacystis, megacolon, and malrotation: a new syndromic association? (21739599)
2011
12
Chagasic megacolon associated with Trypanosoma cruzi I in a Colombian patient. (20502919)
2010
13
CMV infection in a pregnant woman complicated by toxic megacolon and mesenteric vein thrombosis. (19821211)
2009
14
Morbidity and mortality assessment of modified Duhamel operation with immediate mechanical end-to-side colorectal anastomosis for chagasic megacolon: the role of the diverting stoma. (17394005)
2008
15
Toxic megacolon in children with inflammatory bowel disease: clinical and radiographic characteristics. (18510624)
2008
16
The enteric nervous system in chagasic and idiopathic megacolon. (17325489)
2007
17
Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon. (16048580)
2005
18
Advances in the diagnosis and management of toxic megacolon. (15776138)
2005
19
Congenital megacolon: diagnosis using size of sub-mucosal nerve trunk as a criteria. (12081127)
2002
20
Megacolon in pigs due to segmental colon aganglionosis. (11449915)
2001
21
Successful treatment of megacolon associated with colitis with a nitric oxide synthase inhibitor. (11467676)
2001
22
Sub-total colectomy for perforated toxic megacolon in pregnancy. (15512196)
1998
23
Sciatica as a manifestation of idiopathic megacolon: a previously undescribed causal relationship. (9738732)
1998
24
Megacolon in cats. The role of colectomy. (8503161)
1993
25
Surgery of chagasic megacolon. (1903231)
1991
26
Toxic megacolon and perforation caused by Salmonella. (2302504)
1990
27
Megacolon in rats. (2373271)
1990
28
Toxic megacolon and perforation caused by Shigella. (2688808)
1989
29
Function of the striated anal sphincter during straining in control subjects and constipated patients with a radiologically normal rectum or idiopathic megacolon. (3198990)
1988
30
Megaesophagus, megacolon and cancer. (3151134)
1988
31
Waardenburg syndrome, Hirschsprung megacolon, and Marcus Gunn ptosis. (3631139)
1987
32
Megacolon in Zimbabwe: is there a new idiopathic variety? A preliminary report. (3792253)
1986
33
Toxic megacolon complicating Campylobacter enterocolitis. (3734370)
1986
34
Megacolon in adults. (4041749)
1985
35
Funnel anus and megacolon in an adult. (4064858)
1985
36
Toxic megacolon in typhoid fever. (4062466)
1985
37
Intracolonic formation of struvite crystals in a patient with congenital megacolon. (6976282)
1982
38
Toxic megacolon. Part I: Pathogenesis, diagnosis and treatment. (6265121)
1981
39
Lower oesophageal sphincter response to pentagastrin in chagasic patients with megaoesophagus and megacolon. (6769753)
1980
40
Surgical treatment of toxic megacolon and proposal for a program of therapy. (7425218)
1980
41
An assessment of anorectal motility in the management of adult megacolon. (7427031)
1980
42
Toxic megacolon--unusual complication of pseudomembranous colitis. (589788)
1977
43
Diagnosis, surgical management and prognosis of toxic megacolon, a complication of ulcerative colitis. (866982)
1977
44
Acquired aganglionic megacolon in a premature infant: report of a case. (1172231)
1975
45
Hirschsprung's disease, aganglionic or hypoganglionic megacolon. Animal model: aganglionic megacolon in piebald and spotted mutant mouse strains. (1124798)
1975
46
Electrical activity of the intestine of mice with hereditary megacolon and absence of enteric ganglion cells. (4705095)
1973
47
Diagnosis of congenital megacolon: an analysis of 501 patients. (4752993)
1973
48
Radiographic evaluation of toxic megacolon in acute ulcerative colitis. (4484006)
1972
49
Toxic megacolon. A surgical disease. (5546331)
1971
50
Non-tropical sprue as a cause of megacolon. Report of a case. (5492579)
1970

Variations for Megacolon

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Expression for genes affiliated with Megacolon

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Search GEO for disease gene expression data for Megacolon.

Pathways for genes affiliated with Megacolon

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Pathways related to Megacolon according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3GAST, HTR2A, EDNRB

Compounds for genes affiliated with Megacolon

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Compounds related to Megacolon according to GeneCards Suite gene sharing:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1cinanserin4310.2HTR2A, ACHE
2clotiapine4310.2HTR2A, DRD2
3(11c)-n-methylspiperone4310.2HTR2A, DRD2
4l-741,62659 2811.2HTR2A, DRD2
5melperone4310.2HTR2A, DRD2
6amperozide4310.2HTR2A, DRD2
7eedq4310.2HTR2A, DRD2
8tiapride4310.2ACHE, DRD2
9molindone28 1211.2DRD2, HTR2A
10hexamethonium43 2811.2VIP, ACHE
11amisulpride43 28 1212.2DRD2, HTR2A
12zuclopenthixol43 49 1212.1HTR2A, DRD2
13(+)-butaclamol43 2811.1HTR2A, DRD2
14aniracetam43 28 1212.1HTR2A, DRD2
15remoxipride43 1211.1HTR2A, DRD2
16fluspirilene28 43 1212.1HTR2A, DRD2
17loxapine28 43 1212.1HTR2A, DRD2
18thiothixene28 1211.1HTR2A, DRD2
19flupenthixol43 49 1212.1DRD2, HTR2A
20minigastrin4310.1GAST, VIP
21granisetron49 43 1212.0HTR2A, DRD2
22raclopride43 2811.0HTR2A, DRD2
23roxindole28 4311.0DRD2, HTR2A
24amoxapine28 43 1212.0HTR2A, DRD2
256-hydroxydopamine4310.0NRTN, DRD2, VIP
26buspirone43 28 1212.0HTR2A, DRD2
27donepezil43 49 24 1213.0HTR2A, ACHE
28bromocriptine43 28 1211.9DRD2, HTR2A, VIP
29terguride43 2810.9HTR2A, DRD2
30minaprine43 1210.9DRD2, ACHE, HTR2A
31fluphenazine28 43 49 1212.8HTR2A, DRD2
32haloperidol43 49 28 2 1213.8VIP, HTR2A, DRD2
33ritanserin43 2810.8DRD2, HTR2A
34piperazine43 1210.8HTR2A, DRD2
35atropine43 28 1211.7GAST, ACHE, VIP
36octreotide43 59 28 1212.7VIP, DRD2, GAST
37spiperone43 2810.7HTR2A, DRD2
38yohimbine43 2 28 1212.7HTR2A, DRD2, GAST
39pirenzepine43 28 1211.7GAST, DRD2, ACHE
40apomorphine28 43 1211.6DRD2, HTR2A, BLVRB
41ng-nitro-l-arginine439.5GAST, VIP, BLVRB
42promethazine43 1210.5HTR2A, DRD2
43choline43 24 1211.4NRTN, ACHE, VIP, BLVRB
445-hydroxytryptamine439.2EDNRB, VIP, HTR2A, DRD2, GAST
45norepinephrine43 24 1211.2EDNRB, VIP, HTR2A, DRD2, GAST
46gaba439.1BLVRB, VIP, DRD2, GAST
47adenylate438.8EDNRB, BLVRB, VIP, DRD2, GAST
48acetylcholine43 49 28 24 1212.3GAST, EDNRB, BLVRB, VIP, ACHE, DRD2
49glutamate438.2EDNRB, BLVRB, VIP, ACHE, DRD2, NRTN
50dopamine43 28 24 1211.2BLVRB, VIP, HTR2A, ACHE, DRD2, NRTN

GO Terms for genes affiliated with Megacolon

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Cellular components related to Megacolon according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304249.2NRTN, DRD2, ACHE, HTR2A

Biological processes related to Megacolon according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of penile erectionGO:006040610.2VIP, EDNRB
2negative regulation of potassium ion transportGO:004326710.2HTR2A, VIP
3negative regulation of synaptic transmission, glutamatergicGO:005196710.0DRD2, HTR2A
4behavioral response to cocaineGO:004814810.0HTR2A, DRD2
5positive regulation of urine volumeGO:003581010.0DRD2, EDNRB
6regulation of sensory perception of painGO:005193010.0EDNRB, VIP
7positive regulation of neuroblast proliferationGO:000205210.0DRD2, SOX10
8neural crest cell migrationGO:000175510.0EDNRB, SOX10, NRTN
9positive regulation of renal sodium excretionGO:003581510.0DRD2, EDNRB
10peripheral nervous system developmentGO:000742210.0SOX10, EDNRB
11temperature homeostasisGO:00016599.9HTR2A, DRD2
12negative regulation of adenylate cyclase activityGO:00071949.8DRD2, EDNRB
13release of sequestered calcium ion into cytosolGO:00512099.7DRD2, HTR2A
14melanocyte differentiationGO:00303189.7SOX10, EDNRB
15nervous system developmentGO:00073999.6EDNRB, ACHE, NRTN, KIAA1279
16enteric nervous system developmentGO:00484848.9KIF26A, SOX10, TLX2, EDNRB

Molecular functions related to Megacolon according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ionotropic glutamate receptor bindingGO:00352559.3DRD2, FLOT2
2protein bindingGO:00055157.5SOX10, FLOT2, VIP, FOXP3, ACHE, DRD2

Products for genes affiliated with Megacolon

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Sources for Megacolon

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3CDC
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25ICD10
26ICD10 via Orphanet
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28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
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46OMIM via Orphanet
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51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet