MCID: MGC001
MIFTS: 60

Megacolon malady

Gastrointestinal diseases category
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Summaries for Megacolon

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Wikipedia:65 Megacolon is an abnormal dilation of the colon (a part of the large intestine). The dilation is often... more...

MalaCards based summary: Megacolon, also known as megacolon excluding hirschsprung's disease, is related to toxic megacolon and constipation. An important gene associated with Megacolon is SOX10 (SRY (sex determining region Y)-box 10), and among its related pathways is Gastrin-CREB signalling pathway via PKC and MAPK. The compounds cinanserin and clotiapine have been mentioned in the context of this disorder. Affiliated tissues include colon, smooth muscle and spinal cord, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Disease Ontology:8 A colonic disease that is characterized by an abnormal dilation of the colon.

Aliases & Classifications for Megacolon

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Megacolon, Aliases & Descriptions:

Name: Megacolon 8 10 62
Megacolon Excluding Hirschsprung's Disease 8 62
Megacolon, Other Than Hirschsprung's 8
Megacolon, Not Hirschsprung's 8
 
Pathological Dilatation 62
Dilatation of Colon 8
Megacolon Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:11372
MeSH34 D008531
NCIt39 C34810
ICD1025 K59.3

Related Diseases for Megacolon

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Diseases related to Megacolon via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1toxic megacolon32.2TMC1, FLOT2
2constipation31.4VIP
3multiple endocrine neoplasia30.4VIP, GAST
4intestinal pseudo-obstruction30.2ACHE
5hirschsprung's disease30.2ACHE, VIP, SOX10, BLVRB, EDNRB, NRTN
6pheochromocytoma29.9VIP, DRD2, EDNRB
7achalasia29.8BLVRB, VIP, GAST, ACHE
8parkinson's disease29.1BLVRB, HTR2A, ACHE, DRD2, NRTN
9colitis10.9
10ulcerative colitis10.7
11goldberg-shprintzen megacolon syndrome10.4
12megaesophagus10.4
13huntington's disease10.4DRD2
14pathological gambling10.4DRD2
15intestinal obstruction10.4EDNRB
16neuroleptic malignant syndrome10.4DRD2
17crohn's disease10.4
18chagas disease10.4
19neuronitis10.4
20waardenburg syndrome type 410.4EDNRB, SOX10
21waardenburg's syndrome10.3SOX10, EDNRB
22impotence10.3EDNRB, VIP
23pancreatic islet cell tumors10.3VIP, GAST
24somatostatinoma10.3GAST, VIP
25endocrine gland cancer10.3GAST, VIP
26clostridium difficile colitis10.3
27vipoma10.3GAST, VIP
28glucagonoma10.3VIP, GAST
29pyloric stenosis10.3BLVRB, GAST
30hyperprolactinemia10.2VIP, DRD2
31sensorineural hearing loss10.2TMC1, EDNRB, SOX10
32gastrinoma10.2VIP, GAST
33piebaldism10.2
34binswanger's disease10.2VIP, ACHE
35myxedema10.2
36crohn's colitis10.2
37hypoganglionosis10.2
38cytomegalovirus infection10.2
39inflammatory bowel disease10.2
40movement disease10.2DRD2, NRTN
41bipolar disorder10.2HTR2A, DRD2
42antisocial personality disorder10.1HTR2A, DRD2
43gilles de la tourette syndrome10.1DRD2, HTR2A
44serotonin syndrome10.1GAST, HTR2A
45neurofibromatosis10.1
46colon cancer10.1
47compartment syndrome10.1
48diarrhea10.1
49obsessive-compulsive disorder10.1HTR2A, DRD2
50schizoaffective disorder10.1DRD2, HTR2A

Graphical network of the top 20 diseases related to Megacolon:



Diseases related to megacolon

Symptoms for Megacolon

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Drugs & Therapeutics for Megacolon

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Drug clinical trials:

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Genetic Tests for Megacolon

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Anatomical Context for Megacolon

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MalaCards organs/tissues related to Megacolon:

32
Colon, Smooth muscle, Spinal cord, Bone marrow, Bone, Heart, Lung, Myeloid

Animal Models for Megacolon or affiliated genes

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Publications for Megacolon

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Articles related to Megacolon:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
The KIT gene is associated with the english spotting coat color locus and congenital megacolon in Checkered Giant rabbits (Oryctolagus cuniculus). (24736498)
2014
2
Histopathologic findings in patients with idiopathic megacolon: a comparison between dilated and non-dilated loops. (24387755)
2014
3
Is really megacolon a contraindication to infliximab in Crohn's disease? (24592552)
2013
4
Reduced population of interstitial cells of Cajal in Chagasic megacolon. (23435133)
2012
5
Acute colonic pseudo-obstruction in acromegalic patient with dolicho-megacolon mimicking colonic volvulus. (22798128)
2012
6
Preponderance of inhibitory versus excitatory intramuscular nerve fibres in human chagasic megacolon. (22729712)
2012
7
Long-term follow up of abdominal rectosigmoidectomy with posterior end-to-side stapled anastomosis for Chagas megacolon. (19906053)
2011
8
Megacolon from Chagas disease in an ancient Texan. Diagnosis: Chagas disease causing mega-disease, in this case megacolon. (21640110)
2011
9
Megacystis, megacolon, and malrotation: a new syndromic association? (21739599)
2011
10
Chagasic megacolon associated with Trypanosoma cruzi I in a Colombian patient. (20502919)
2010
11
CMV infection in a pregnant woman complicated by toxic megacolon and mesenteric vein thrombosis. (19821211)
2009
12
Expression of caspase-3 in enteric cells is related to development of chagasic megacolon. (19289186)
2009
13
Morbidity and mortality assessment of modified Duhamel operation with immediate mechanical end-to-side colorectal anastomosis for chagasic megacolon: the role of the diverting stoma. (17394005)
2008
14
Toxic megacolon in children with inflammatory bowel disease: clinical and radiographic characteristics. (18510624)
2008
15
The enteric nervous system in chagasic and idiopathic megacolon. (17325489)
2007
16
Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon. (16048580)
2005
17
Advances in the diagnosis and management of toxic megacolon. (15776138)
2005
18
Congenital megacolon: diagnosis using size of sub-mucosal nerve trunk as a criteria. (12081127)
2002
19
Megacolon in pigs due to segmental colon aganglionosis. (11449915)
2001
20
Successful treatment of megacolon associated with colitis with a nitric oxide synthase inhibitor. (11467676)
2001
21
Sub-total colectomy for perforated toxic megacolon in pregnancy. (15512196)
1998
22
Sciatica as a manifestation of idiopathic megacolon: a previously undescribed causal relationship. (9738732)
1998
23
Megacolon in cats. The role of colectomy. (8503161)
1993
24
Surgery of chagasic megacolon. (1903231)
1991
25
Toxic megacolon and perforation caused by Salmonella. (2302504)
1990
26
Megacolon in rats. (2373271)
1990
27
Toxic megacolon and perforation caused by Shigella. (2688808)
1989
28
Function of the striated anal sphincter during straining in control subjects and constipated patients with a radiologically normal rectum or idiopathic megacolon. (3198990)
1988
29
Megaesophagus, megacolon and cancer. (3151134)
1988
30
Waardenburg syndrome, Hirschsprung megacolon, and Marcus Gunn ptosis. (3631139)
1987
31
Megacolon in Zimbabwe: is there a new idiopathic variety? A preliminary report. (3792253)
1986
32
Toxic megacolon complicating Campylobacter enterocolitis. (3734370)
1986
33
Megacolon in adults. (4041749)
1985
34
Funnel anus and megacolon in an adult. (4064858)
1985
35
Toxic megacolon in typhoid fever. (4062466)
1985
36
Intracolonic formation of struvite crystals in a patient with congenital megacolon. (6976282)
1982
37
Observations on the immunocytes and macrophages in megacolon. (7044725)
1982
38
Lower oesophageal sphincter response to pentagastrin in chagasic patients with megaoesophagus and megacolon. (6769753)
1980
39
Surgical treatment of toxic megacolon and proposal for a program of therapy. (7425218)
1980
40
An assessment of anorectal motility in the management of adult megacolon. (7427031)
1980
41
Toxic megacolon--unusual complication of pseudomembranous colitis. (589788)
1977
42
Diagnosis, surgical management and prognosis of toxic megacolon, a complication of ulcerative colitis. (866982)
1977
43
Acquired aganglionic megacolon in a premature infant: report of a case. (1172231)
1975
44
Hirschsprung's disease, aganglionic or hypoganglionic megacolon. Animal model: aganglionic megacolon in piebald and spotted mutant mouse strains. (1124798)
1975
45
Electrical activity of the intestine of mice with hereditary megacolon and absence of enteric ganglion cells. (4705095)
1973
46
Diagnosis of congenital megacolon: an analysis of 501 patients. (4752993)
1973
47
Radiographic evaluation of toxic megacolon in acute ulcerative colitis. (4484006)
1972
48
Megacolon, including Hirschsprung's disease. (4649366)
1972
49
Toxic megacolon. A surgical disease. (5546331)
1971
50
Non-tropical sprue as a cause of megacolon. Report of a case. (5492579)
1970

Variations for Megacolon

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Expression for genes affiliated with Megacolon

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Expression patterns in normal tissues for genes affiliated with Megacolon

Search GEO for disease gene expression data for Megacolon.

Pathways for genes affiliated with Megacolon

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Pathways related to Megacolon according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3GAST, HTR2A, EDNRB

Compounds for genes affiliated with Megacolon

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Compounds related to Megacolon according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1cinanserin4410.2ACHE, HTR2A
2clotiapine4410.2DRD2, HTR2A
3(11c)-n-methylspiperone4410.2DRD2, HTR2A
4l-741,62661 2811.2HTR2A, DRD2
5melperone4410.2HTR2A, DRD2
6amperozide4410.2DRD2, HTR2A
7eedq4410.2DRD2, HTR2A
8tiapride4410.2ACHE, DRD2
9amisulpride44 28 1112.2DRD2, HTR2A
10molindone28 1111.2DRD2, HTR2A
11zuclopenthixol44 50 1112.1HTR2A, DRD2
12hexamethonium44 2811.1ACHE, VIP
13(+)-butaclamol44 2811.1DRD2, HTR2A
14aniracetam44 28 1112.1HTR2A, DRD2
15thiothixene28 1111.1DRD2, HTR2A
16remoxipride44 1111.1HTR2A, DRD2
17loxapine28 44 1112.1DRD2, HTR2A
18fluspirilene28 44 1112.1DRD2, HTR2A
19flupenthixol44 50 1112.1HTR2A, DRD2
20minigastrin4410.1GAST, VIP
21raclopride44 2811.1DRD2, HTR2A
22granisetron50 44 1112.0HTR2A, DRD2
23roxindole28 4411.0HTR2A, DRD2
24amoxapine28 44 1112.0HTR2A, DRD2
256-hydroxydopamine4410.0DRD2, VIP, NRTN
26buspirone44 28 1112.0HTR2A, DRD2
27bromocriptine44 28 1111.9VIP, DRD2, HTR2A
28terguride44 2810.9DRD2, HTR2A
29fluphenazine28 44 50 1112.9HTR2A, DRD2
30minaprine44 1110.9DRD2, ACHE, HTR2A
31donepezil44 50 24 1112.9HTR2A, ACHE
32haloperidol44 50 28 2 1113.8DRD2, HTR2A, VIP
33piperazine44 1110.8DRD2, HTR2A
34ritanserin44 2810.8DRD2, HTR2A
35atropine44 28 1111.7VIP, ACHE, GAST
36octreotide44 61 28 1112.7DRD2, GAST, VIP
37promethazine44 1110.7HTR2A, DRD2
38yohimbine44 2 28 1112.7GAST, DRD2, HTR2A
39pirenzepine44 28 1111.7ACHE, GAST, DRD2
40apomorphine28 44 1111.6BLVRB, HTR2A, DRD2
41ng-nitro-l-arginine449.5BLVRB, GAST, VIP
42spiperone44 2810.5HTR2A, DRD2
43choline44 24 1111.4NRTN, BLVRB, ACHE, VIP
445-hydroxytryptamine449.2GAST, DRD2, HTR2A, VIP, EDNRB
45norepinephrine44 24 1111.2HTR2A, GAST, EDNRB, VIP, DRD2
46gaba449.1GAST, BLVRB, VIP, DRD2
47adenylate448.8DRD2, VIP, GAST, EDNRB, BLVRB
48acetylcholine44 50 28 24 1112.3BLVRB, EDNRB, VIP, ACHE, DRD2, NRTN
49glutamate448.2ACHE, BLVRB, GAST, EDNRB, NRTN, VIP
50dopamine44 28 24 1111.2DRD2, NRTN, GAST, ACHE, HTR2A, BLVRB

GO Terms for genes affiliated with Megacolon

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Cellular components related to Megacolon according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.2NRTN, DRD2, ACHE, HTR2A

Biological processes related to Megacolon according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of penile erectionGO:06040610.2VIP, EDNRB
2negative regulation of potassium ion transportGO:04326710.2HTR2A, VIP
3negative regulation of synaptic transmission, glutamatergicGO:05196710.0DRD2, HTR2A
4behavioral response to cocaineGO:04814810.0HTR2A, DRD2
5positive regulation of urine volumeGO:03581010.0DRD2, EDNRB
6regulation of sensory perception of painGO:05193010.0EDNRB, VIP
7positive regulation of neuroblast proliferationGO:00205210.0DRD2, SOX10
8neural crest cell migrationGO:00175510.0EDNRB, SOX10, NRTN
9positive regulation of renal sodium excretionGO:03581510.0DRD2, EDNRB
10peripheral nervous system developmentGO:00742210.0SOX10, EDNRB
11temperature homeostasisGO:0016599.9HTR2A, DRD2
12negative regulation of adenylate cyclase activityGO:0071949.8DRD2, EDNRB
13release of sequestered calcium ion into cytosolGO:0512099.7DRD2, HTR2A
14melanocyte differentiationGO:0303189.7SOX10, EDNRB
15nervous system developmentGO:0073999.6EDNRB, ACHE, NRTN, KIAA1279
16enteric nervous system developmentGO:0484848.9KIF26A, SOX10, TLX2, EDNRB

Molecular functions related to Megacolon according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ionotropic glutamate receptor bindingGO:0352559.3DRD2, FLOT2
2protein bindingGO:0055157.5SOX10, FLOT2, VIP, FOXP3, ACHE, DRD2

Products for genes affiliated with Megacolon

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Sources for Megacolon

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3CDC
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25ICD10
26ICD10 via Orphanet
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29KEGG
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36MGI
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