MCID: MGC001
MIFTS: 45

Megacolon malady

Category: Gastrointestinal diseases

Aliases & Classifications for Megacolon

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Aliases & Descriptions for Megacolon:

Name: Megacolon 11 39 13 68
 
Dilatation of Colon 11

Classifications:



External Ids:

Disease Ontology11 DOID:11372
ICD1030 K59.3
MeSH39 D008531
NCIt45 C34810

Summaries for Megacolon

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Disease Ontology:11 A colonic disease that is characterized by an abnormal dilation of the colon.

MalaCards based summary: Megacolon, also known as dilatation of colon, is related to hirschsprung disease 1 and shprintzen-goldberg syndrome. An important gene associated with Megacolon is SOX10 (SRY-Box 10), and among its related pathways are Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) and Synthesis of PC. Affiliated tissues include colon, smooth muscle and spinal cord, and related mouse phenotypes are limbs/digits/tail and normal.

Related Diseases for Megacolon

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Diseases related to Megacolon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1hirschsprung disease 132.6EDNRB, GDNF, RET
2shprintzen-goldberg syndrome31.3EDN3, EDNRB, GDNF, KIF1BP, RET
3toxic megacolon12.4
4goldberg-shprintzen megacolon syndrome12.3
5hirschsprung disease 211.3
6ulcerative colitis11.2
7hirschsprung disease 610.7
8hirschsprung disease 910.7
9hirschsprung disease 310.7
10hirschsprung disease 510.7
11hirschsprung disease 810.7
12hirschsprung disease 710.7
13hirschsprung disease 410.7
14ifap syndrome with or without bresheck syndrome10.7
15autoimmune gastrointestinal dysmotility10.7
16colitis10.5
17deafness, mitochondrial, modifier of10.3EDNRB, SOX10
18epiphyseal dysplasia, multiple, 310.3EDN3, EDNRB
19waardenburg syndrome, type 4a10.2EDNRB, RET
20wdha syndrome10.2EDN3, EDNRB, SOX10
21waardenburg syndrome, type 310.2EDN3, SOX10
22apocrine adenoma10.2EDNRB, RET, SOX10
23cervical adenofibroma10.2EDN3, EDNRB, SOX10
24familial cold autoinflammatory syndrome 410.1ACHE, RET
25ceroid lipofuscinosis, neuronal, 510.1EDN3, EDNRB, RET, SOX10
26myopathy of extraocular muscle10.1EDN3, EDNRB, RET, SOX10
27meigel disease10.1GDNF, RET
28constipation10.1
29cytomegalic congenital adrenal hypoplasia10.1DRD2, HTR2A, SOX10
30uterine ligament clear cell adenocarcinoma10.0EDNRB, FOXP3, RET
31megaesophagus10.0
32neuronitis10.0
33teratoma with malignant transformation10.0DRD2, HTR2A
34hypoparathyroidism-intellectual disability-dysmorphism syndrome10.0ACHE, GDNF, RET
35crohn's disease10.0
36chagas disease10.0
37neutropenia, severe congenital, 5, autosomal recessive10.0EDNRB, GDNF, RET
38sweat gland cancer9.9EDNRB, GDNF, RET, VIP
39clostridium difficile colitis9.9
40splenic abscess9.9DRD2, HTR2A
41inflammatory bowel disease9.8
42cytomegalovirus infection9.8
43epithelioid type angiomyolipoma9.8ACHE, CHAT, GDNF, HTR2A
44piebaldism9.8
45crohn's colitis9.8
46myxedema9.8
47hypoganglionosis9.8
48hemochromatosis, type 2a9.8DRD2, GDNF, NRTN
49spinal cord injury9.7
50diarrhea9.7

Graphical network of the top 20 diseases related to Megacolon:



Diseases related to megacolon

Symptoms & Phenotypes for Megacolon

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MGI Mouse Phenotypes related to Megacolon according to GeneCards Suite gene sharing:

41 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.5CHAT, DRD2, EDNRB, FOXP3, RET, SOX10
2MP:00028738.9CHAT, DRD2, FOXP3, PHOX2B, RET, SOX10
3MP:00053698.7ACHE, CHAT, DRD2, EDNRB, GDNF, HTR2A
4MP:00053858.5CHAT, DRD2, EDNRB, FOXP3, GDNF, PHOX2B
5MP:00053798.5DRD2, EDNRB, FOXP3, GDNF, HTR2A, NRTN
6MP:00053888.3ACHE, CHAT, DRD2, EDNRB, FOXP3, PHOX2B
7MP:00053818.2CHAT, DRD2, EDN3, EDNRB, FOXP3, GDNF
8MP:00053898.0ACHE, CHAT, DRD2, FOXP3, GDNF, NRTN
9MP:00053917.9ACHE, CHAT, EDNRB, FOXP3, NRTN, PHOX2B
10MP:00053787.7ACHE, CHAT, DRD2, EDNRB, FOXP3, GDNF
11MP:00036317.5ACHE, CHAT, DRD2, EDN3, EDNRB, GDNF
12MP:00053867.1ACHE, CHAT, DRD2, EDN3, EDNRB, FOXP3
13MP:00107686.3ACHE, CHAT, DRD2, EDN3, EDNRB, FOXP3

Drugs & Therapeutics for Megacolon

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Drugs for Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
VancomycinapprovedPhase 4, Phase 2, Phase 33321404-90-6441141, 14969
Synonyms:
(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-Oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid
(2.2Sp,3.5sa,2.6sp)-O(4.2),C(3.4):c(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]
1404-90-6
1404-93-9 (hydrochloride)
64685-75-2 (sulfate)
AC1L24VU
AC1L9AMI
AC1Q29OH
BIDD:GT0353
C06689
C66H75Cl2N9O24
CHEBI:28001
CHEMBL262777
CID14969
CID441141
CID5311496
CID6426898
CID6917992
D00212
DB00512
EINECS 215-772-6
HSDB 3262
LMPK14000004
 
LS-161387
Lopac0_001267
MolPort-001-794-649
NCGC00162383-02
Prestwick0_000497
Prestwick1_000497
Prestwick2_000497
SPBio_002314
UNII-6Q205EH1VU
VAN
VANCOMYCIN
Vancocin
Vancocin (TN)
Vancocin HCL
Vancomicina
Vancomicina [INN-Spanish]
Vancomycin
Vancomycin (USP)
Vancomycin HCL
Vancomycin [USAN:INN:BAN]
Vancomycine
Vancomycine [INN-French]
Vancomycinum
Vancomycinum [INN-Latin]
nchembio.350-comp1
2Anti-Infective AgentsPhase 4, Phase 2, Phase 322062
3Anti-Bacterial AgentsPhase 4, Phase 2, Phase 311226
4VaccinesPhase 46611
5
MetronidazoleapprovedPhase 2, Phase 3486443-48-14173
Synonyms:
1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole
1-(β-ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(β-oxyethyl)-2-methyl-5-nitroimidazole
1-Hydroxyethyl-2-methyl-5-nitroimidazole
2-(2-methyl-5-nitroimidazol-1-yl)ethanol
2-Methyl-5-nitro-1-imidazoleethanol
2-Methyl-5-nitroimidazole-1-ethanol
2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole
2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole
2-methyl-5-nitroimidazole-1-ethanol
443-48-1
46461_FLUKA
46461_RIEDEL
69198-10-3 (mono-hydrochloride)
99616-64-5
AB00052046
AC-10556
AC1L1HKS
AC1Q2P2Z
AKOS000269646
APMN
ARONIS24285
Acromona
Anagiardil
Apo-Metronidazole
Arilin
Atrivyl
BAS 02983617
BAY-5360
BCBcMAP01_000184
BIDD:GT0107
BPBio1_000004
BRD-K52020312-001-05-2
BRN 0611683
BSPBio_000002
BSPBio_002031
Bayer 5360
Bexon
Bio-0694
CAS-443-48-1
CB-01-14 MMX
CCRIS 410
CHEBI:39845
CHEBI:6909
CHEMBL137
CID4173
CONT
CPD000058175
Caswell No. 579AA
Clont
D00409
DB00916
Danizol
Deflamon
Deflamon-wirkstoff
DivK1c_000007
EINECS 207-136-1
EPA Pesticide Chemical Code 120401
Efloran
Elyzol
Entizol
Eumin
FLAGYL I.V. RTU IN PLASTIC CONTAINER
Flagemona
Flagesol
Flagil
Flagyl
Flagyl (TN)
Flagyl 375
Flagyl Er
Flagyl I.V.
Flagyl I.V. RTU
Flegyl
Florazole
Fossyol
Giatricol
Ginefla vir
Gineflavir
HMS1568A04
HMS1920N19
HMS2051G07
HMS2090B19
HMS2091F14
HMS500A09
HMS547C19
HSDB 3129
I14-0667
IDI1_000007
IDR-90105
KBio1_000007
KBio2_001515
KBio2_004083
KBio2_006651
KBio3_001531
KBioGR_000559
KBioSS_001515
Klion
Klont
LS-1264
M0924
M1547_SIGMA
M3761_FLUKA
M3761_SIGMA
M9036_SIGMA
METRO I.V
METRONIDAZOLE USP
MLS000028590
MLS000758286
Maybridge1_001999
Meronidal
Methronidazole
Methyl-5-nitroimidazole-1-ethanol
 
Metric
Metric 21
Metro Cream
Metro Gel
Metro I.V.
Metro I.V. In Plastic Container
MetroCream
MetroGel
MetroGel-Vaginal
MetroLotion
Metrodzhil
Metrogel-vaginal (TN)
Metrogyl
Metrolag
Metrolyl
Metromidol
Metronidaz
Metronidazol
Metronidazol [INN-Spanish]
Metronidazole (JP15/USP/INN)
Metronidazole Benzoate
Metronidazole Monohydrochloride
Metronidazole Phosphoester
Metronidazole [USAN:INN:BAN:JAN]
Metronidazole in Plastic Container
Metronidazolo
Metronidazolo [DCIT]
Metronidazolum
Metronidazolum [INN-Latin]
Metrotop
Metrozine
Metryl
Mexibol
Mexibol 'silanes'
MolPort-000-141-892
MolPort-002-502-101
Monagyl
Monasin
NCGC00016446-01
NCGC00016446-02
NCGC00022059-03
NCGC00022059-04
NCGC00022059-05
NCIOpen2_000337
NIDA
NINDS_000007
NSC 50364
NSC 69587
NSC-50364
NSC50364
NSC69587
Nalox
Nidagel
Noritate
Noritate (TN)
Novonidazol
Orvagil
Prestwick0_000081
Prestwick1_000081
Prestwick2_000081
Prestwick3_000081
Prestwick_334
Protostat
RP 8823
RP-8823
Rathimed
Rosased
S1907_Selleck
SAM001247010
SBB041018
SC 10295
SMP1_000189
SMR000058175
SPBio_000666
SPBio_001941
SPECTRUM1500412
STK177359
Sanatrichom
Satric
Spectrum2_000883
Spectrum3_000506
Spectrum4_000060
Spectrum5_001289
Spectrum_001035
Takimetol
Trichazol
Trichex
Tricho cordes
Tricho-gynaedron
Trichocide
Trichomol
Trichomonacid 'pharmachim'
Trichopal
Trichopol
Tricocet
Tricom
Tricowas B
Trikacide
Trikamon
Trikojol
Trikozol
Trimeks
Trivazol
UNII-140QMO216E
Vagilen
Vagimid
Vandazole
Vertisal
WLN: T5N CNJ A2Q B1 ENW
WLN: T5N CNJA2Q B1 ENW
WLN: T6NTJ DQ ANU1- ET5N CNJ A1 BNW
Wagitran
ZERO/004064
ZINC00113442
Zadstat
Zidoval
giniflavir
metronidazole
neo-Tric
6Gastrointestinal AgentsPhase 2, Phase 38402
7Antibiotics, AntitubercularPhase 2, Phase 37180
8Antiprotozoal AgentsPhase 2, Phase 32051
9LaxativesPhase 2, Phase 3537
10Polyethylene glycol 3350Phase 2, Phase 396
11Antitubercular AgentsPhase 2, Phase 31343
12CatharticsPhase 2, Phase 3537
13Antiparasitic AgentsPhase 2, Phase 32199
14
Lactuloseapproved1014618-18-211333
Synonyms:
(2S,3R,4S,5R,6R)-2-[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
4-O-b-D-Galactopyranosyl-D-Fructofuranose
4-O-b-D-Galactopyranosyl-D-fructose
4-O-beta-D-Galactopyranosyl-D-Fructofuranose
4-O-beta-D-Galactopyranosyl-D-fructofuranose
4-O-beta-D-Galactopyranosyl-D-fructose
4-O-beta-delta-Galactopyranosyl-delta-Fructofuranose
4-O-beta-delta-Galactopyranosyl-delta-fructose
 
Bifiteral
Cephulac
D-Lactulose
Lactulosa
Lactulose
Lactulosum
delta-Lactulose
lactulosa
lactulosum
15
Pancrelipaseapproved97053608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
PA
 
Pancreatic alpha-amylase precursor
Pancrelipase (amylase
lipase
protease)
16Immunoglobulins6394
17Antibodies6394
18pancreatin970
19ColaNutraceuticalEarly Phase 11946

Interventional clinical trials:

(show all 23)
idNameStatusNCT IDPhase
1Optimal Treatment for Recurrent Clostridium DifficileRecruitingNCT02667418Phase 4
2Probiotics for Prophylaxis of Postoperative Hirschsprungs Associated EnterocolitisRecruitingNCT02343562Phase 4
3Immunodeficiency in Cartilage-hair Hypoplasia: Sub-project on Safety of Vaccination Against ChickenpoxEnrolling by invitationNCT02383797Phase 4
4Intestinal Lavage for the Treatment of Severe C. Difficile InfectionsRecruitingNCT02466698Phase 2, Phase 3
5Endoscopic Mucosal Resection (EMR) for Diagnosis of Hirschsprung's DiseaseUnknown statusNCT00671684Phase 1, Phase 2
6Probiotic Prophylaxis of Hirschprung's Disease Associated Enterocolitis (HAEC)CompletedNCT00630838Phase 2
7A Trial on Treatments of Hirschsprung Allied DiseaseUnknown statusNCT02212054Early Phase 1
8Fast-track Surgery in the Treatment of Hirschsprung's DiseaseUnknown statusNCT02350088
9A New Scoring System Improves Diagnostic Accuracy of Intestinal Dysganglionosis --a Prospective StudyUnknown statusNCT02216994
10Comparison of Circular(Soave) and Heart-shaped Anastomosis in Hirschsprung's Disease: A Prospective Multicenter Randomized Controlled TrialUnknown statusNCT02234219
11Host Immune Response to Clostridium Difficile Infection (ICD)CompletedNCT02440438
12A Trial on Conservative Treatment for Infants' Hirschsprung DiseaseCompletedNCT01985646Early Phase 1
13A Trial on Probiotics in Preventing Hirschsprung's Disease Associated EntercolitisCompletedNCT01934959Early Phase 1
14Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated ColitisRecruitingNCT01959048
15Genetic Mosaicism in Hirschsprung's DiseaseRecruitingNCT01927809
16Abdominal SepsiS Study: Epidemiology of Etiology and OutcomeRecruitingNCT02442596
17Enhanced Recovery After Surgery In Hirschsprung DiseaseRecruitingNCT02776176
18Hirschsprung Disease Genetic StudyRecruitingNCT00478712
193D High Resolution Anorectal Manometry in Children After Surgery for Anorectal DisordersRecruitingNCT02296008
20Endoscopic Mucosal Resection for the Diagnosis of a-Ganglionosis, a Controlled Prospective Trial (EDGE Trial)RecruitingNCT01515501
21MICROPRUNG : Intestinal Microbiota Analysis in Patients With or Without Hirschsprung's Associated EnteroColitisRecruitingNCT02857205
22Identification Genetic, Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung DiseaseRecruitingNCT02193685
23Electrophysiological Activity of the Anorectum in Children Suspected of Hirschsprung DiseaseNot yet recruitingNCT02342457

Search NIH Clinical Center for Megacolon


Cochrane evidence based reviews: megacolon

Genetic Tests for Megacolon

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Anatomical Context for Megacolon

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MalaCards organs/tissues related to Megacolon:

36
Colon, Smooth muscle, Spinal cord, Bone, Bone marrow, Skin, Myeloid

Publications for Megacolon

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Articles related to Megacolon:

(show top 50)    (show all 565)
idTitleAuthorsYear
1
Neurogenic Megacolon in Spinal Cord Injury. (27959751)
2016
2
Enteric Neuronal Damage, Intramuscular Denervation and Smooth Muscle Phenotype Changes as Mechanisms of Chagasic Megacolon: Evidence from a Long-Term Murine Model of Tripanosoma cruzi Infection. (27045678)
2016
3
Concomitant Laparoscopic Ileocolectomy and Ladd's Procedure for Crohn's Ileocolitis with Mesenteric Abscess and Congenital Megacolon. (27670550)
2016
4
Toxic Megacolon: A Review for Emergency Department Clinicians. (27185628)
2016
5
Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality. (27281569)
2016
6
Characteristics of chronic megacolon among patients diagnosed with multiple endocrine neoplasia type 2B. (27403312)
2016
7
Concomitant Laparoscopic Ileocolectomy and Ladds Procedure for Crohns Ileocolitis with Mesenteric Abscess and Congenital Megacolon. (27930275)
2016
8
Toxic megacolon and interstitial pneumonia caused by cytomegalovirus infection in a pediatric patient with acute lymphoblastic leukemia receiving chemotherapy. (28090493)
2016
9
Induction of potentially lethal hypermagnesemia, ischemic colitis, and toxic megacolon by a preoperative mechanical bowel preparation: report of a case. (26943694)
2016
10
Severe hyponatremia and repeated intestinal resections for intestinal dysmotility mimicking congenital aganglionic megacolon due to delay in the diagnosis of congenital hypothyroidism. (28164077)
2016
11
Campylobacter colitis: Rare cause of toxic megacolon. (27614338)
2016
12
Male-biased aganglionic megacolon in the TashT mouse line due to perturbation of silencer elements in a large gene desert of chromosome 10. (25786024)
2015
13
A megacolon with a skin lesion. (25858639)
2015
14
Treating congenital megacolon by transplanting GDNF and GFRI+-1 double genetically modified rat bone marrow mesenchymal stem cells. (26345878)
2015
15
Perianal neuroendocrine tumor with suspected lymph node metastasis causing colonic compression and subsequent megacolon. (25750442)
2015
16
Increasing Incidence of and Increased Mortality Associated With Clostridium difficile-Associated Megacolon. (26445319)
2015
17
Clinical Features and Colonic Motor Disturbances in Chronic Megacolon in Adults. (25868630)
2015
18
Goldberg-Shprintzen megacolon syndrome with associated sensory motor axonal neuropathy. (25846562)
2015
19
Fecal Microbiota Transplant for Clostridium difficile Colitis-Induced Toxic Megacolon. (25942309)
2015
20
Toxic colonoscopy--how investigating active inflammatory bowel disease can lead to the serious complication of toxic megacolon. (26202312)
2015
21
Trypanosomiasis-induced megacolon illustrates how myenteric neurons modulate the risk for colon cancer in rats and humans. (25884710)
2015
22
A case of toxic megacolon caused by clostridium difficile infection and treated with fecal microbiota transplantation. (25721003)
2015
23
Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. (25866348)
2015
24
Toxic megacolon during pregnancy in ulcerative colitis: A case report. (25942749)
2015
25
A case of perforated chronic idiopathic megacolon. (26411850)
2015
26
The Surgical Treatment of Toxic Megacolon in Hirschsprung Disease. (26181500)
2015
27
Minimally invasive approach to chagasic megacolon: laparoscopic rectosigmoidectomy with posterior end-to-side low colorectal anastomosis. (24710265)
2014
28
Could the complications of megacolon be avoided by monitoring the risk patients? cases report. (25149623)
2014
29
Fecal Transplant for Treatment of Toxic Megacolon Associated With Clostridium Difficile Colitis in a Patient With Duchenne Muscular Dystrophy. (24858336)
2014
30
Blood vessels in Ganglia in human esophagus might explain the higher frequency of megaesophagus compared with megacolon. (25351549)
2014
31
Surgical Management of Toxic Megacolon. (26176049)
2014
32
Toxic megacolon in ulcerative rectocolitis. Current trends in clinical evaluation, diagnosis and treatment. (24755987)
2014
33
Difficulties in the diagnostics and treatment of near-total congenital megacolon. (25375063)
2014
34
Toxic colitis with megacolon in a patient with malrotation. (25513909)
2014
35
Surgical treatment of chagasic megacolon with Duhamel-Habr-Gama technique modulated by frozen-section examination. (24824159)
2014
36
Histopathologic findings in patients with idiopathic megacolon: a comparison between dilated and non-dilated loops. (24387755)
2014
37
Colonic decompression and direct intraluminal medical therapy for Clostridium difficile-associated megacolon using a tube placed endoscopically in the proximal colon. (24134562)
2014
38
Oral tacrolimus for megacolon in patients with severe ulcerative colitis. (25130105)
2014
39
Toxic megacolon after abdominoplasty: a case report. (24667886)
2014
40
The KIT gene is associated with the english spotting coat color locus and congenital megacolon in Checkered Giant rabbits (Oryctolagus cuniculus). (24736498)
2014
41
Chagasic megacolon: enteric neurons and related structures. (25059649)
2014
42
Is really megacolon a contraindication to infliximab in Crohn's disease? (24592552)
2013
43
From impending toxic megacolon to multiple organ failure in severe ulcerative colitis. (22923362)
2013
44
Treatment of aganglionic megacolon mice via neural stem cell transplantation. (23512482)
2013
45
Megacolon for a giant faecaloma with unlucky outcome Case report and review of the literature. (23857039)
2013
46
Unusual Complication of Toxic Megacolon in Typhoid Colitis. (23900751)
2013
47
The development of chagasic megacolon requires severe denervation and the reduction in interstitial cells of Cajal number might be a contributing factor. (23224119)
2013
48
Nonresectional surgical approach to toxic megacolon with abdominal compartment syndrome. (24351341)
2013
49
Toxic Megacolon and Acute Ischemia of the Colon due to Sigmoid Stenosis Related to Diverticulitis. (24163654)
2013
50
Interstitial cells of Cajal: crucial for the development of megacolon in human Chagas' disease? (23810202)
2013

Variations for Megacolon

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Expression for genes affiliated with Megacolon

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Search GEO for disease gene expression data for Megacolon.

Pathways for genes affiliated with Megacolon

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GO Terms for genes affiliated with Megacolon

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Cellular components related to Megacolon according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304249.2DRD2, HTR2A, NRTN, RET

Biological processes related to Megacolon according to GeneCards Suite gene sharing:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1artery smooth muscle contractionGO:001482410.6EDN3, HTR2A
2neurotransmitter biosynthetic processGO:004213610.6ACHE, CHAT
3negative regulation of adenylate cyclase activityGO:000719410.6DRD2, EDNRB
4positive regulation of neuroblast proliferationGO:000205210.6DRD2, SOX10
5positive regulation of renal sodium excretionGO:003581510.5DRD2, EDNRB
6posterior midgut developmentGO:000749710.5EDNRB, RET
7melanocyte differentiationGO:003031810.5EDN3, EDNRB, SOX10
8response to painGO:004826510.5EDNRB, RET
9behavioral response to cocaineGO:004814810.5DRD2, HTR2A
10negative regulation of synaptic transmission, glutamatergicGO:005196710.5DRD2, HTR2A
11mRNA stabilizationGO:004825510.5GDNF, VIP
12developmental pigmentationGO:004806610.4EDNRB, ZEB2
13positive regulation of urine volumeGO:003581010.4DRD2, EDNRB
14peristalsisGO:003043210.3DRD2, GDNF
15peripheral nervous system developmentGO:000742210.3EDNRB, GDNF, SOX10
16regulation of dopamine secretionGO:001405910.2DRD2, HTR2A
17neuron differentiationGO:003018210.2EDN3, PHOX2B, RET
18regulation of dopamine uptake involved in synaptic transmissionGO:005158410.1DRD2, GDNF
19temperature homeostasisGO:000165910.1DRD2, HTR2A
20vasoconstrictionGO:004231010.1EDN3, EDNRB
21vein smooth muscle contractionGO:001482610.0EDN3, EDNRB
22sympathetic nervous system developmentGO:00484859.9GDNF, PHOX2B
23positive regulation of cell proliferationGO:00082849.6EDN3, EDNRB, GDNF, HTR2A, VIP
24enteric nervous system developmentGO:00484849.6EDNRB, GDNF, PHOX2B, RET, SOX10
25neural crest cell migrationGO:00017558.9EDN3, EDNRB, GDNF, NRTN, RET, SOX10
26positive regulation of transcription from RNA polymerase II promoterGO:00459448.4DRD2, FOXP3, GDNF, PHOX2B, SOX10, ZEB2
27nervous system developmentGO:00073998.3ACHE, EDNRB, GDNF, KIF1BP, NRTN, RET

Molecular functions related to Megacolon according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Ras guanyl-nucleotide exchange factor activityGO:000508810.1GDNF, NRTN, RET
2receptor bindingGO:00051029.1DRD2, EDN3, GDNF, NRTN

Sources for Megacolon

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet