Megakaryoblastic Leukemia malady

MalaCards: Megakaryoblastic Leukemia, also known as acute megakaryocytic leukemias, is related to acute megakaryoblastic leukemia and down syndrome. An important gene associated with Megakaryoblastic Leukemia is MKL1 (megakaryoblastic leukemia (translocation) 1), and among its related pathways are Breast Cancer Regulation by Stathmin1 and IL-6 Pathway. The compounds threonine and methylcellulose have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, smooth muscle and skeletal muscle, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

megakaryoblastic leukemia 7 acute megakaryocytic leukemias 43

Diseases related to megakaryoblastic leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 606)

id	Related Disease	Score	Top Affiliating Genes
1	acute megakaryoblastic leukemia	37.4	MPO, CD36, MLL, MKL1, IL11, IL3
2	down syndrome	35.7	JAK2, MNX1, MLL, FLT3, ETV6, RUNX1
3	myelofibrosis	31.7	MPL, THPO, EPO
4	megakaryocytic leukemia	31.6	KITLG, VWF, RBM15, RBM6, MPO, JAK2
5	myeloproliferative disorder	30.8	KIT, KITLG, VWF, SELP, MPL, MPO
6	acute myeloid leukemia	30.6	PICALM, KIT, FLT3, RUNX1
7	twinning	27.7	VWF, VDR, MPO, CD36, MNX1, MLL
8	leukemia	23.6	PICALM, KIT, KITLG, VWF, RBM15, RBM15B
9	acute leukemia	23.3	PICALM, KIT, KITLG, VWF, SELP, BMP6
10	myeloid leukemia	19.9	PICALM, KIT, KITLG, VWF, RBM15, SELP
11	acute myelomonocytic leukemia	14.0	MPO, MLL, ETV6, CSF1R, RUNX1
12	congenital amegakaryocytic thrombocytopenia	13.9	MPL, IL3, THPO
13	essential thrombocythemia	13.9	MPL, JAK2, THPO
14	cyclic thrombocytopenia	13.9	IL3, IL6, THPO
15	myeloid sarcoma	13.9	KIT, MPO, MLL, FLT3
16	stem cell leukemia	13.9	KIT, MPO, FLT3, RUNX1, GATA1
17	cyclic hematopoiesis	13.9	IL3, CSF2, CSF3
18	severe congenital neutropenia	13.9	IL3, CSF2, CSF3
19	thrombocytopenia, x-linked	13.9	ZFPM1, THPO, GATA1
20	hemorrhagic thrombocythemia	13.8	MPL, JAK2, THPO
21	bone marrow cancer	13.8	KIT, FLT3, IL3
22	chronic neutrophilic leukemia	13.8	MLL, CSF2, CSF3
23	acute myeloid leukemia, adult	13.8	KIT, MLL, FLT3, ABCB1, ABCG2, NUP98
24	hemorrhagic disease	13.8	VWF, CD36, PF4, RUNX1
25	chronic myelomonocytic leukemia	13.8	MPO, JAK2, FLT3, IL3, ETV6, NUP98
26	leukemoid reaction	13.8	KITLG, IL3, CSF2, CSF3, GATA1
27	felty's syndrome	13.7	IL3, CSF2, CSF3
28	macrothrombocytopenia	13.7	CD36, ITGA2B, ITGB3, GP9, THPO, GATA1
29	mast-cell sarcoma	13.7	KIT, KITLG, MPO
30	acquired polycythemia	13.7	JAK2, EPO, EPOR
31	mast cell neoplasm	13.7	KIT, KITLG, FLT3, IL3
32	juvenile myelomonocytic leukemia	13.7	JAK2, FLT3, STAT5A, CSF2, RUNX1
33	myeloid malignancy	13.7	KIT, MPL, JAK2, MLL, FLT3, ETV6
34	gray platelet syndrome	13.7	SELP, CD36, GP9, GATA1
35	mast-cell leukemia	13.6	KIT, KITLG, MPO
36	bernard-soulier syndrome	13.6	VWF, ITGA2B, ITGB3, GP9, THPO
37	interleukin-7 receptor alpha deficiency	13.6	KIT, IL6R, STAT5A
38	aggressive systemic mastocytosis	13.6	KIT, KITLG, STAT5A
39	hypersplenism	13.6	IL11, THPO, CSF2, CSF3, EPO
40	protein c deficiency	13.6	JAK2, CBS, PF4, CSF3, ADAMTSL1
41	blood platelet disease	13.6	VWF, SELP, PF4, RUNX1
42	beta thalassemia	13.6	CD151, EPO, GATA1
43	thrombocytopenia due to platelet alloimmunization	13.6	SELP, MPL, ITGA2B, THPO
44	primary polycythemia	13.6	JAK2, STAT5A, EPO, EPOR
45	acute lymphoblastic leukemia, childhood	13.5	MLL, FLT3, ETV6, NR3C1, ABCB1, RUNX1
46	virus associated hemophagocytic syndrome	13.5	MLL, IL2, CSF3
47	malignant fibrous histiocytoma	13.5	KITLG, IL3, IL6, IL6R, ABCB1, CSF1R
48	dna topoisomerase ii	13.5	CDKN1A, MLL, SUMO1, ABCB1, NUP98, RUNX1
49	fibrous histiocytoma	13.5	KITLG, IL3, IL6, IL6R, ABCB1, CSF1R
50	lymphoblastic lymphoma	13.5	PICALM, BMP6, CDKN1A, MLL, ETV6, ABCB1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to megakaryoblastic leukemia:

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MGI Mouse Phenotypes related to megakaryoblastic leukemia:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.9	MNX1, IL2, ETV6, SPEN, CSF1R, MKL1
2	respiratory system phenotype	MP:0005388	9.8	CBS, MNX1, GATA1, SELP, SRF, ITGB3
3	craniofacial phenotype	MP:0005382	9.4	KITLG, MLL, KIT, CSF2, EDNRB, EDN1
4	embryogenesis phenotype	MP:0005380	9.2	ETV6, ERG, EDNRB, NUP98, RUNX1, CBS
5	liver/biliary system phenotype	MP:0005370	9.0	CD36, ZFPM1, KIT, PICALM, MLL, MKL2
6	no phenotypic analysis	MP:0003012	8.8	RUNX1, PML, SYK, EPOR, UBE2I, MLL
7	limbs/digits/tail phenotype	MP:0005371	8.7	MLL, VDR, KITLG, KIT, ESR1, CBS
8	renal/urinary system phenotype	MP:0005367	8.7	MLL, CD151, CD63, CDKN1A, SELP, MAP3K9
9	reproductive system phenotype	MP:0005389	8.4	TAGLN, PTK2, MLL, VDR, RAP1B, ADCY10
10	normal phenotype	MP:0002873	8.4	IL6R, MAP3K9, STAT5A, PML, ETV6, SUMO1
11	hematopoietic system phenotype	MP:0005397	8.3	ETV6, ERG, GATA1, TRAF3, EPOR, EPO
12	nervous system phenotype	MP:0003631	8.1	NR3C1, EDN1, RHOA, SELP, SPEN, GSN
13	integument phenotype	MP:0010771	8.0	PTK2, ETV6, CBS, GSN, MKL1, MLL
14	skeleton phenotype	MP:0005390	7.9	ITGB3, CDKN1A, JAK2, BMP6, VDR, KITLG
15	behavior/neurological phenotype	MP:0005386	7.9	MLL, MKL1, IL2, IL6, IL6R, MNX1
16	digestive/alimentary phenotype	MP:0005381	7.4	SUMO1, TAGLN, IL9, MAP3K9, ETV6, ESR1
17	muscle phenotype	MP:0005369	7.1	PRKCA, KIT, MYLK2, MYOCD, BACH1, MPO
18	tumorigenesis	MP:0002006	6.9	CD151, MLL, IL3, ETV6, ESR1, TNF
19	growth/size phenotype	MP:0005378	6.2	KIT, KITLG, SELP, VDR, MYOCD, BMP6
20	immune system phenotype	MP:0005387	6.2	PICALM, ITGA2B, MLL, FLT3, GSN, IL2
21	mortality/aging	MP:0010768	5.6	MKL1, SRF, SPEN, NR3C1, A4GALT, EDN1
22	homeostasis/metabolism phenotype	MP:0005376	4.4	ETV6, SYK, STAT5A, PRKCA, CSF1R, CSF2
23	cardiovascular system phenotype	MP:0005385	4.1	EDN1, GATA1, EDNRB, ABCB1, TAGLN, SYK
24	cellular phenotype	MP:0005384	3.9	ESR1, KIT, CDKN1A, CD36, CD151, MNX1

Articles related to megakaryoblastic leukemia:

(show top 50)    (show all 71)

id	Title	Authors	Year	Affiliating Genes
1	Acute megakaryoblastic leukemia without GATA1 mutatio n after transient myeloproliferative disorder in an infant without Down syndrom e. (21205752)	Inaba H.... Raimondi S.C.	2011	GATA1
2	Description of a novel Janus kinase 3 P132A mutation in acute megakaryoblastic leukemia and demonstration of previously reported Jan us kinase 3 mutations in normal subjects. (21599579)	Riera L.... Inghirami G.	2011	JAK3
3	Megakaryoblastic leukemia protein-1 (MKL1): Increasin g evidence for an involvement in cancer progression and metastasis. (20816842)	Scharenberg M.A.... Asparuhova M.B.	2010	MKL1
4	Megakaryoblastic leukemia factor-1 gene in the suscep tibility to coronary artery disease. (19513752)	Hinohara K.... Kimura A.	2009	MKL1
5	Activating mutations in human acute megakaryoblastic leukemia. (18755984)	Malinge S.... Bernard O.A.	2008	KIT, JAK2, JAK3
6	MNX1-ETV6 fusion gene in an acute megakaryoblastic leukemia and expression of the MNX1 gene in leukemia and normal B cell lines. (18940475)	Taketani T.... Hayashi Y.	2008	ETV6, MNX1
7	A novel mutation in the GATA1 gene associated with acute megakaryoblastic leukemia in a Korean Down syndrome patient. (19119459)	Kim I.S.... Chi H.S.	2008	GATA1
8	High incidence of CALM-AF10 fusion and the identification of a novel fusion transcript in acute megakaryoblastic leukemia in children without Down's syndrome. (17170719)	Abdelhaleem M.... Shago M.	2007	PICALM
9	JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults. (17252020)	Kiyoi H.... Naoe T.	2007	JAK3
10	A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia. (17360941)	Gu T.L.... Polakiewicz R.D.	2007	CSF1R, RBM6
11	JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model. (16804112)	Mercher T.... Gilliland D.G.	2006	JAK2, STAT5A
12	Acute megakaryoblastic leukemia and loss of the RUNX1 gene. (16364766)	Berger R.... Romana S.P.	2006	RUNX1
13	Activating alleles of JAK3 in acute megakaryoblastic leukemia. (16843266)	Walters D.K.... Druker B.J.	2006	JAK3
14	CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. (17071479)	Savasan S.... Ravindranath Y.	2006	CD36
15	Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome. (16628190)	Xu G.... Ito E.	2006	RUNX1, GATA1
16	Cloning and characterization of the novel chimeric gene p53/FXR2 in the acute megakaryoblastic leukemia cell line CMK11-5. (16778363)	Kanezaki R.... Ito E.	2006	FXR2
17	Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification. (16098147)	Nakagawa K.... Kuzumaki N.	2005	UBE2I, SUMO1, MKL1
18	GATA 1 mutations as clonal markers of minimal residual disease in acute megakaryoblastic leukemia of Down syndrome--a new tool with significant potential applications. (15925405)	Hitzler J.... Zipursky A.	2005	GATA1
19	Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in a NUP98-C6orf80 fusion in a case of acute megakaryoblastic leukemia. (16028218)	Tosi S.... Harbott J.	2005	NUP98, CCDC28A
20	MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia. (16111539)	Morerio C.... Panarello C.	2005	MLL
21	Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. (14970199)	Du K.L.... Parmacek M.S.	2004	TAGLN, MKL1, MYOCD
22	Fetal origin of the GATA1 mutation in identical twins with transient myeloproliferative disorder and acute megakaryoblastic leukemia accompanying Down syndrome. (14684662)	Shimada A.... Ito E.	2004	GATA1
23	The GATA1 mutation in an adult patient with acute megakaryoblastic leukemia not accompanying Down syndrome. (15070711)	Harigae H.... Ito E.	2004	GATA1
24	Megakaryoblastic leukemia cell line MOLM-16 derived from minimally differentiated acute leukemia with myeloid/NK precursor phenotype. (12526922)	Matsuo Y.... Orita K.	2003	ITGA2B, SELP, ITGB3
25	The potential effect of short-course high-dose steroid on the maturation and apoptosis of leukemic cells in a child with acute megakaryoblastic leukemia. (12854906)	Hicsonmez G.... Gurgey A.	2003	GP9
26	Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. (14565952)	Selvaraj A.... Prywes R.	2003	SRF, MKL1, MYOCD
27	GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome. (12586620)	Hitzler J.K.... Zipursky A.	2003	GATA1
28	Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. (12172547)	Wechsler J.... Crispino J.D.	2002	GATA1, ZFPM1
29	Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells. (11436981)	Watanabe M.... Higashihara M.	2001	MYL6, MYL12B
30	Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis. (11568009)	Zunino R.... Trifaro J.M.	2001	GSN, SCIN
31	Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. (11431691)	Ma Z.... Hitzler J.K.	2001	MKL1, RBM15
32	Outside-In signaling of soluble and solid-phase fibrinogen through integrin alphaIIbbeta3 is different and cooperative with each other in a megakaryoblastic leukemia cell line, CMK. (9694716)	Tohyama Y.... Yamamura H.	1998	PTK2, SYK
33	Proliferative effect of postapheresis platelet donor plasma on a megakaryoblastic leukemia cell line. (9402848)	Takanashi M.... Juji T.	1997	THPO
34	Endothelin expression in human megakaryoblastic leukemia cell lines and normal platelet precursors. (9110379)	Mathieu M.N.... Chevillard C.	1997	EDNRB, EDN1
35	Differential expression of low Mr GTP-binding proteins in human megakaryoblastic leukemia cell line, MEG-01, and their possible involvement in the differentiation process. (9157598)	Nagata K.... Nozawa Y.	1997	RAC2, RAP1B, RAB6A
36	Demonstration of vitamin D receptor expression in a human megakaryoblastic leukemia cell line: regulation of vitamin D receptor mRNA expression and responsiveness by forskolin. (8639462)	Song L.N.	1996	VDR
37	Protein kinase C isozymes in human megakaryoblastic leukemia cell line, MEG-01: possible involvement of the isozymes in the differentiation process of MEG-01 cells. (8703801)	Nagata K.I.... Nozawa Y.	1996	PRKCA, DYT10
38	Establishment and characterization of a novel human immature megakaryoblastic leukemia cell line, M-MOK, dependent on fibroblasts for its viability. (7589286)	Itano M.... Koike T.	1995	MPO
39	Raf-1 is a necessary component of the mitogenic response of the human megakaryoblastic leukemia cell line MO7 to human stem cell factor, granulocyte-macrophage colony-stimulating factor, interleukin 3, and interleukin 9. (7519043)	Brennscheidt U.... Herrmann F.	1994	KITLG, IL3, TRAF3
40	Immunolocalization of platelet-derived growth factor, transforming growth factor-beta, and fibronectin in acute megakaryoblastic leukemia manifesting tumor formation. (8026832)	Kitagawa M.... Kamiyama R.	1994	CD36
41	Glucocorticoid-induced growth inhibition and differentiation of a human megakaryoblastic leukemia cell line: involvement of glucocorticoid receptor. (8401254)	Song L.N.... Cheng T.	1993	NR3C1
42	Acute megakaryoblastic leukemia in one cat and two dogs. (8470339)	Colbatzky F.... Hermanns W.	1993	VWF, MPO
43	Shape change in human megakaryoblastic leukemia cells, MEG-01 (1613974)	Goto S.... Saito H.	1992	MYLK2
44	Stimulatory effect of tumor necrosis factor-alpha on the growth of CMK, a human megakaryoblastic leukemia cell line. (1313936)	Miura K.... Sato T.	1992	TNF
45	Induction of complete remission in a case of drug-resistant childhood acute megakaryoblastic leukemia by combination of G-CSF and chemotherapy (1374487)	Sugita K.... Miyauchi J.	1992	CSF3
46	Differentiation induction of blast cells in two cases of childhood acute megakaryoblastic leukemia in vitro by interleukin-3 and interleukin-6: an ultrastructural cytochemical study. (1655816)	Miyauchi J.... Shimizu K.	1991	IL6, IL3
47	Thrombin-induced translocation of protein kinase C in human megakaryoblastic leukemia cells (MEG-01). (1952935)	Ito T.... Saito H.	1991	DYT10
48	The production of transforming growth factor-beta in acute megakaryoblastic leukemia and its possible implications in myelofibrosis. (2317561)	Terui T.... Saito H.	1990	BMP6
49	Enhanced expression of thrombomodulin by intracellular cyclic AMP-increasing agents in two human megakaryoblastic leukemia cell lines. (2166972)	Ito T.... Saito H.	1990	ERVW-1
50	Beta-thromboglobulin and platelet factor 4 in a follow-up of acute myelofibrosis (megakaryoblastic leukemia) (2146451)	Palomera Bernal L.... GarcA-a DA-ez I.	1990	PF4

Genes related to megakaryoblastic leukemia according to GeneCards:

(show top 50)    (show all 87)

id	Symbol	Description	Score	GeneCards Section Context
1	MKL1	megakaryoblastic leukemia (translocation) 1	11.1	Transcripts, Publications, Aliases & Descriptions, Orthologs
2	MKL2	MKL/myocardin-like 2	11.1	Publications, Orthologs, Aliases & Descriptions
3	GATA1	GATA binding protein 1 (globin transcription factor 1)	11.0	Publications
4	RBM15	RNA binding motif protein 15	11.0	Publications, Orthologs
5	MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	11.0	Publications
6	RUNX1	runt-related transcription factor 1	11.0	Publications
7	MPO	myeloperoxidase	11.0	Publications
8	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
9	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
10	RBM15B	RNA binding motif protein 15B	11.0	Orthologs
11	CCDC28A	coiled-coil domain containing 28A	11.0	Publications
12	MNX1	motor neuron and pancreas homeobox 1	11.0	Publications
13	GP9	glycoprotein IX (platelet)	11.0	Publications
14	FXR2	fragile X mental retardation, autosomal homolog 2	11.0	Publications
15	BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	11.0	Publications
16	MPL	myeloproliferative leukemia virus oncogene	11.0	Publications
17	SPEN	spen homolog, transcriptional regulator (Drosophila)	11.0	Orthologs
18	SRF	serum response factor (c-fos serum response element-binding transcription factor)	11.0	Publications
19	RBM6	RNA binding motif protein 6	11.0	Publications
20	THPO	thrombopoietin	11.0	Publications
21	CSF1R	colony stimulating factor 1 receptor	11.0	Publications
22	NUP98	nucleoporin 98kDa	11.0	Publications
23	IL11	interleukin 11	11.0
24	PF4	platelet factor 4	11.0	Publications
25	PML	promyelocytic leukemia	11.0	Publications
26	CBS	cystathionine-beta-synthase	11.0
27	EPOR	erythropoietin receptor	11.0
28	PICALM	phosphatidylinositol binding clathrin assembly protein	11.0	Publications
29	FLT3	fms-related tyrosine kinase 3	11.0	Publications
30	IL6R	interleukin 6 receptor	11.0
31	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2	11.0	Publications
32	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
33	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
34	JAK2	Janus kinase 2	11.0	Publications
35	RHOA	ras homolog family member A	11.0
36	ETV6	ets variant 6	11.0	Publications
37	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	11.0	Publications
38	BMP6	bone morphogenetic protein 6	11.0	Publications
39	VWF	von Willebrand factor	11.0	Publications
40	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
41	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
42	MYL12B	myosin, light chain 12B, regulatory	11.0	Publications
43	GNLY	granulysin	11.0	Publications
44	A4GALT	alpha 1,4-galactosyltransferase	11.0	Publications
45	TAGLN	transgelin	11.0	Publications
46	MYLK2	myosin light chain kinase 2	11.0	Publications
47	RAP1B	RAP1B, member of RAS oncogene family	11.0	Publications
48	MYOCD	myocardin	11.0	Orthologs, Publications
49	CD63	CD63 molecule	11.0	Publications
50	CD151	CD151 molecule (Raph blood group)	11.0	Publications

Pathways related to megakaryoblastic leukemia according to GeneDecks:

(show top 50)    (show all 114)

id	Pathway	Score	Top Affiliating Genes
1	Breast Cancer Regulation by Stathmin136	10.6	RAC2, IL9
2	IL-6 Pathway36	10.3	CSF3, CSF2, PF4, IL6R, IL9, IL3
3	Ras Pathway36	10.1	IL3, KIT, RAC2, EPOR, CSF1R, IL9
4	Paxillin Interactions36	10.0	CSF1R, IL3, ITGA2B, ITGB3, FLT3, THPO
5	Actin-Based Motility by Rho Family GTPases36	9.9	RAC2, ITGA2B, GSN, IL2, THPO, IL9
6	RAR-Gamma-RXR-Alpha Degradation36	9.9	CSF3, IL9, IL2, CSF2, PF4, IL3
7	ILK Signaling36	9.8	CSF1R, EPOR, KIT, PTK2, IL3, FLT3
8	Glioma Invasiveness36	9.7	BMP6, IL9, IL3, THPO, KITLG, PTK2
9	Nanog in Mammalian ESC Pluripotency36	9.6	IL2, FLT3, BMP6, KIT, KITLG, IL3
10	JNK Pathway36	9.5	IL6, IL6R, KITLG, BMP6, FLT3, THPO
11	NFAT in Immune Response36	9.3	CSF1R, EPOR, IL2, KIT, KITLG, BMP6
12	PTEN Pathway36	9.3	IL2RA, PTK2, KIT, IL2, ITGA2B, RAC2
13	PEDF Induced Signaling36	9.3	IL2, IL3, TNF, IL11, BMP6, SRF
14	14-3-3 Induced Intracellular Signaling36	9.3	FLT3, KITLG, EPOR, CSF1R, THPO, TNF
15	MIF Regulation of Innate Immune Cells36	9.2	CSF3, PF4, BMP6, IL11, IL2, IL9
16	all-trans-Retinoic Acid Signaling in Brain36	9.2	CSF3, IL6, CSF2, PF4, IL9, BMP6
17	Jak-STAT signaling pathway20	9.2	CSF2, STAT5A, EPOR, EPO, CSF3, IL9
18	Pancreatic Adenocarcinoma36	9.2	IL3, IL6, KIT, KITLG, BMP6, JAK2
19	Telomerase Components in Cell Signaling36	9.1	KITLG, IL3, PRKCA, IL9, IL2, BMP6
20	MIF Mediated Glucocorticoid Regulation36	9.1	IL6, NR3C1, TNF, IL9, IL3, IL2
21	Pathways in cancer20	9.1	STAT5A, TRAF3, FLT3, ITGA2B, CDKN1A, RAC2
22	eNOS Signaling36	9.0	EPOR, CSF1R, THPO, ESR1, IL9, KIT
23	Glucocorticoid Receptor Signaling36	9.0	NR3C1, STAT5A, IL11, IL2, IL2RA, IL3
24	Rac1 Pathway36	9.0	KIT, KITLG, IL6, IL9, PTK2, THPO
25	Apoptotic Pathways in Synovial Fibroblasts36	8.9	IL2RA, THPO, TNF, IL6, IL3, BMP6
26	Activation of PKC through GPCR36	8.9	RAP1B, KIT, THPO, KITLG, PRKCA, IL9
27	p70S6K Signaling36	8.9	KIT, IL3, IL6, PRKCA, IL9, THPO
28	Mitochondrial Apoptosis36	8.8	PRKCA, KIT, KITLG, BMP6, IL2, IL2RA
29	JAK-STAT Pathway36	8.8	KIT, KITLG, BMP6, UBE2I, MPL, JAK2
30	PPAR Pathway36	8.7	IL6, THPO, TNF, IL9, IL3, IL2RA
31	Akt Signaling36	8.7	THPO, CSF2, EPOR, PF4, PTK2, KIT
32	Renin-Angiotensin Pathway36	8.7	THPO, JAK2, PTK2, IL9, IL6, IL3
33	Activation of PKA through GPCR36	8.7	RAP1B, FLT3, CSF1R, PRKCA, THPO, IL9
34	GPCR Pathway36	8.6	IL6, IL3, IL2, FLT3, RAC2, RAP1B
35	MAPK Family Pathway36	8.6	RAC2, IL11, IL2, IL2RA, IL3, IL6R
36	STAT3 Pathway36	8.6	TNF, BMP6, JAK2, IL9, MAP3K9, IL6R
37	Estrogen Pathway36	8.5	KIT, KITLG, THPO, ESR1, IL9, IL6
38	Cellular Apoptosis Pathway36	8.5	THPO, PML, KIT, BMP6, IL2, IL2RA
39	Molecular Mechanisms of Cancer36	8.5	PF4, PTK2, IL9, IL6R, IL6, IL3
40	Phospholipase-C Pathway36	8.4	KIT, PRKCA, IL3, SYK, THPO, IL9
41	PAK Pathway36	8.4	IL2RA, IL3, PF4, THPO, CSF3, CSF2
42	Hematopoietic cell lineage20	8.4	KIT, KITLG, IL6, IL3, IL2RA, IL11
43	Cytokine-cytokine receptor interaction20	8.4	EPOR, EPO, KIT, KITLG, MPL, FLT3
44	Endothelin-1 Signaling Pathway36	8.3	EPOR, CSF3, CSF2, CSF1R, IL11, BMP6
45	p38 Signaling36	8.2	PF4, BMP6, KITLG, KIT, PRKCA, THPO
46	Antioxidant Action of Vitamin-C36	8.1	IL2, CSF1R, KIT, KITLG, IL2RA, BMP6
47	Rho Family GTPases36	8.1	EPOR, ITGA2B, RAC2, BMP6, KITLG, KIT
48	MAPK Signaling36	7.6	BMP6, IL3, EPOR, IL2, KIT, KITLG
49	Tec Kinases Signaling36	7.4	TNF, IL9, IL6R, IL6, IL3, IL2RA
50	ERK Signaling36	7.2	IL6, IL3, IL2, IL11, FLT3, ITGB3

Compounds related to megakaryoblastic leukemia according to GeneDecks:

(show top 50)    (show all 303)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.6	MYLK2, MPL, MLL, FLT3, GP9, CSF1R
2	methylcellulose32	9.8	KIT, KITLG, FLT3, IL11, IL3, IL6
3	agar32	9.6	KITLG, JAK2, IL9, ETV6, ERVW-1, PF4
4	pge232	9.5	PTK2, PF4, RHOD, EDN1, EDNRB, ADCY10
5	pixy32132	9.5	KITLG, FLT3, IL11, IL3, IL6, THPO
6	gp 13032	9.4	KIT, BMP6, MPL, JAK2, FLT3, IL2RA
7	epinephrine32 9 18 9	12.4	KITLG, SELP, BMP6, RAP1B, JAK2, CD63
8	h2o232	9.3	KITLG, VWF, MPO, JAK2, IL2RA, IL3
9	ly29400232	9.3	RAP1B, IL6, TNF, PTK2, RHOD, SYK
10	etoposide32 42 9 9	12.2	CDKN1A, MLL, FLT3, IL3, PTK2, NR3C1
11	rapamycin32 42	10.0	KIT, KITLG, JAK2, IL2, PTK2, RHOD
12	cytarabine32 34 9 9	11.9	KIT, KITLG, MPO, CDKN1A, CD36, FLT3
13	fibrinogen32	8.9	SELP, CD63, CD9, CD151, ITGA2B, ITGB3
14	aspartate32	8.7	SELP, VDR, BMP6, MLL, IL11, GP9
15	doxorubicin32 34 9 9	11.6	KIT, KITLG, BMP6, MLL, FLT3, IL11
16	steroid32	8.6	KIT, KITLG, UBE2I, JAK2, ITGB3, GSN
17	prednisolone32 9 9	10.5	KITLG, VWF, BMP6, MPO, MLL, IL2
18	wortmannin32 42	9.4	KITLG, MYLK2, RAP1B, JAK2, CDKN1A, CD63
19	sb 20358032 42	9.3	VDR, BMP6, CDKN1A, CD36, IL6, TNF
20	estrogen32	8.2	VWF, VDR, CD36, ITGB3, IL11, ESR1
21	imatinib32 34 9 9	11.2	KIT, KITLG, BMP6, JAK2, CDKN1A, FLT3
22	calcitriol32 42 9 18 9	12.2	KITLG, VDR, BMP6, CDKN1A, CD36, MLL
23	cysteine32	8.1	SELP, VDR, RAB6A, UBE2I, BACH1, MPL
24	gm-csf32	8.1	KITLG, BMP6, IL11, IL2, IL3, IL6
25	5fluorouracil32	8.0	KIT, KITLG, VDR, MPL, MPO, CDKN1A
26	12-o-tetradecanoylphorbol 13-acetate32	8.0	BMP6, JAK2, CDKN1A, CD9, ITGA2B, IL3
27	hydrocortisone32 9 9	10.0	KITLG, BMP6, CD36, IL2, IL3, IL6
28	paclitaxel32 34 9 9	10.9	KIT, KITLG, BMP6, CDKN1A, GSN, IL11
29	fmlp32	7.8	SELP, RAC2, MPO, GSN, IL3, TNF
30	cyclosporin a32 42	8.8	KITLG, VWF, SELP, VDR, JAK2, IL11
31	butyrate32	7.8	KITLG, VDR, BMP6, MPO, JAK2, CDKN1A
32	alanine32	7.8	KITLG, VWF, VDR, MYLK2, BMP6, MPL
33	oligonucleotide32	7.8	KIT, VWF, BMP6, JAK2, CDKN1A, CD9
34	rantes32	7.6	KITLG, SELP, BMP6, CD63, CD9, IL11
35	herbimycin a32 42	8.5	KITLG, BMP6, JAK2, CD36, FLT3, IL11
36	pd 98,05932	7.5	KIT, KITLG, BMP6, JAK2, CDKN1A, IL3
37	actinomycin d32	7.1	KIT, KITLG, VDR, JAK2, CDKN1A, MLL
38	arachidonic acid32 9 18 9	10.1	KITLG, VWF, SELP, MYLK2, RAC2, JAK2
39	calcium32 9 18 9	9.7	KIT, KITLG, VWF, MYL6, MYLK2, MYOCD
40	adp32 18	7.6	KIT, VWF, SELP, MYLK2, RAP1B, MPL
41	thymidine32 18	7.5	KIT, KITLG, VDR, BMP6, JAK2, CDKN1A
42	dexamethasone32 42 34 9 9	10.4	KITLG, VWF, SELP, VDR, BMP6, JAK2
43	phosphatidylinositol32	6.3	KIT, KITLG, BMP6, RAB6A, RAP1B, RAC2
44	histamine32 18	7.2	KIT, KITLG, VWF, SELP, BMP6, SCIN
45	vegf32	6.2	KIT, KITLG, VWF, SELP, MPL, MPO
46	cycloheximide32	5.8	KIT, KITLG, VDR, BMP6, JAK2, CDKN1A
47	genistein32 9 18 9	8.7	KITLG, SELP, VDR, JAK2, CDKN1A, CD36
48	serine32	5.1	KIT, KITLG, VWF, VDR, MYLK2, BMP6
49	retinoic acid32 42 18	7.0	KIT, KITLG, VWF, SELP, VDR, MYOCD
50	tyrosine32	4.6	KIT, KITLG, VWF, SELP, BMP6, RAB6A

Cellular components related to megakaryoblastic leukemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule membrane	GO:031092	9.7	ITGA2B, CD9, CD36, SELP, ITGB3
2	external side of plasma membrane	GO:009897	8.9	TNF, KIT, VWF, SELP, CD36, CD9
3	integral to plasma membrane	GO:005887	8.4	EPOR, CSF1R, SELP, CD36, CD63, CD9
4	extracellular space	GO:005615	7.4	KIT, GNLY, TNF, PF4, EDN1, THPO
5	cytosol	GO:005829	5.8	RHOA, RHOD, SYK, STAT5A, PRKCA, NUP98
6	plasma membrane	GO:005886	5.7	ABCB1, ABCG2, SYK, PRKCA, CSF1R, ADCY10

Biological processes related to megakaryoblastic leukemia according to GeneDecks:

(show all 38)

id	Name	GO ID	Score	Top Affiliating Genes
1	myeloid progenitor cell differentiation	GO:002318	10.7	KIT, FLT3, RUNX1
2	dendritic cell differentiation	GO:097028	10.6	GATA1, FLT3, CSF2
3	megakaryocyte differentiation	GO:030219	10.6	ZFPM1, GATA1, IL11
4	megakaryocyte development	GO:035855	10.6	KIT, SRF, ZFPM1
5	positive regulation of tyrosine phosphorylation of Stat3 protein	GO:042517	10.6	KIT, CSF1R, JAK2, IL6, IL6R
6	platelet formation	GO:030220	10.5	ZFPM1, GATA1, SRF
7	positive regulation of MAPK cascade	GO:043410	10.5	KIT, CD36, FLT3, IL11, IL6, IL6R
8	hemopoiesis	GO:030097	10.4	KITLG, FLT3, KIT, CSF1R, RUNX1
9	embryonic hemopoiesis	GO:035162	10.4	GATA1, IL3, MLL, ZFPM1, KITLG, RUNX1
10	erythrocyte differentiation	GO:030218	10.4	ZFPM1, JAK2, GATA1, KIT
11	positive regulation of survival gene product expression	GO:045885	10.2	IL3, STAT5A, CSF2
12	virus-host interaction	GO:019048	10.0	NUP98, SPEN, ITGB3, UBE2I, RBM15B, RBM15
13	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.0	JAK2, GATA1, KITLG, SYK, CD36, ITGB3
14	peptidyl-tyrosine phosphorylation	GO:018108	10.0	PTK2, SYK, FLT3, STAT5A, JAK2, KIT
15	cytokine-mediated signaling pathway	GO:019221	10.0	CSF1R, CSF3, NUP98, STAT5A, PF4, SUMO1
16	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.0	KIT, FLT3, PTK2, SELP, JAK2
17	protein autophosphorylation	GO:046777	10.0	MYLK2, KIT, JAK2, FLT3, SYK, MAP3K9
18	positive regulation of DNA replication	GO:045740	9.9	IL3, EPO, CSF2, KITLG
19	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.9	IL3, EPO, CSF2, KIT, JAK2, IL2
20	negative regulation of lipid storage	GO:010888	9.9	IL6, ITGB3, TNF
21	positive regulation of interleukin-6 production	GO:032755	9.9	CD36, IL6, TNF, IL6R
22	defense response to Gram-positive bacterium	GO:050830	9.8	CD36, TNF, IL6R, IL6
23	negative regulation of heart contraction	GO:045822	9.8	JAK2, PRKCA, IL2
24	platelet degranulation	GO:002576	9.8	PF4, ITGB3, ITGA2B, CD9, CD63, CD36
25	positive regulation of anti-apoptosis	GO:045768	9.8	IL6R, IL6, GATA1, CDKN1A
26	positive regulation of inflammatory response	GO:050729	9.4	IL2, STAT5A, PRKCA, JAK2
27	positive regulation of smooth muscle cell proliferation	GO:048661	9.3	IL6R, PRKCA, EDN1, TNF, IL6
28	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	EDN1, JAK2, TNF, ESR1
29	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.3	ESR1, KIT, SRF, MYOCD, TNF, IL6
30	positive regulation of MAP kinase activity	GO:043406	9.2	EDN1, TNF, FLT3, KITLG
31	positive regulation of protein phosphorylation	GO:001934	9.0	CSF1R, PTK2, TNF, PRKCA, ITGB3
32	negative regulation of apoptotic process	GO:043066	9.0	TNF, GATA1, EPO, PF4, CDKN1A, CSF2
33	cell adhesion	GO:007155	8.7	PRKCA, GP9, IL2, ITGA2B, CD151, ITGB3
34	positive regulation of cell proliferation	GO:008284	8.7	IL3, IL6R, IL9, PTK2, EDN1, THPO
35	negative regulation of cell proliferation	GO:008285	8.6	MYOCD, VDR, SCIN, JAK2, IL6, CD9
36	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.5	GATA1, IL2, MKL2, MLL, BMP6, MYOCD
37	platelet activation	GO:030168	8.3	THPO, PF4, PTK2, GP9, IL6, ITGB3
38	blood coagulation	GO:007596	8.3	CD36, CD63, ITGA2B, ITGB3, GP9, PTK2

Molecular functions related to megakaryoblastic leukemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:042803	9.5	SRF, NR3C1, ABCG2, CSF1R, PML, CBS
2	growth factor activity	GO:008083	9.1	IL9, THPO, CSF2, CSF3, IL6, IL3
3	cytokine activity	GO:005125	8.4	CSF2, BMP6, IL11, IL2, IL3, IL6
4	protein binding	GO:005515	3.6	RHOA, FLT3, MKL2, MKL1, MLL, ITGB3