MCID: MGK001
MIFTS: 47

Megakaryocytic Leukemia malady

Rare diseases, Cancer diseases, Blood diseases categories

Summaries for Megakaryocytic Leukemia

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Disease Ontology:10 A leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers.

MalaCards based summary: Megakaryocytic Leukemia, also known as acute megakaryoblastic leukemia, is related to leukemia and acute leukemia. An important gene associated with Megakaryocytic Leukemia is MKL1 (megakaryoblastic leukemia (translocation) 1), and among its related pathways are Lymphocyte Signaling and IL-3 Signaling Pathway. Affiliated tissues include bone, bone marrow and myeloid, and related mouse phenotypes are cardiovascular system and growth/size/body.

Aliases & Classifications for Megakaryocytic Leukemia

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Sources:
32LifeMap Discovery®, 10Disease Ontology, 11diseasecard, 43NIH Rare Diseases, 12DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 35MeSH, 29ICD9CM, 57SNOMED-CT, 40NCIt, 28ICD10 via Orphanet, 27ICD10
See all sources

Megakaryocytic Leukemia, Aliases & Descriptions:

Name: Megakaryocytic Leukemia 32 10 12
Acute Megakaryoblastic Leukemia 10 43 49
Acute Megakaryocytic Leukemias 10 62
Acute Megakaryoblastic Leukaemia, Fab M7 10
Acute Megakaryoblastic Leukemia, Fab M7 10
Acute Myeloblastic Leukemia Type 7 49
 
Acute Megakaryoblastic Leukaemia 62
Megakaryoblastic Leukemia, Acute 11
Megakaryoblastic Leukemia Acute 45
Megakaryocytic Myelosis 10
Thrombocytic Leukaemia 10
Amkl 49


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

49
acute megakaryoblastic leukemia:
Age of onset: Childhood


External Ids:

Disease Ontology10 DOID:8761
MeSH35 D007947
ICD9CM29 207.2
NCIt40 C3170
Orphanet49 518
ICD10 via Orphanet28 C94.2
ICD1027 C94.2

Related Diseases for Megakaryocytic Leukemia

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Graphical network of the top 20 diseases related to Megakaryocytic Leukemia:



Diseases related to megakaryocytic leukemia

Symptoms for Megakaryocytic Leukemia

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Drugs & Therapeutics for Megakaryocytic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Megakaryocytic Leukemia

Search NIH Clinical Center for Megakaryocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Megakaryocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Megakaryocytic Leukemia

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Anatomical Context for Megakaryocytic Leukemia

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MalaCards organs/tissues related to Megakaryocytic Leukemia:

33
Bone, Bone marrow, Myeloid, Monocytes, Liver

Animal Models for Megakaryocytic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Megakaryocytic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.6GATA1, IL11RA, GFI1B, MKL1
2MP:00053788.5TRIB1, GATA1, IL11RA, MKL1
3MP:00053768.2MKL1, GFI1B, CSF2RB, GATA1, TRIB1
4MP:00053848.1RBM15, GATA1, GFI1B, MKL1
5MP:00107687.9RBM15, GATA1, IL11RA, GFI1B, MKL1
6MP:00053977.3GFI1B, IL11RA, CSF2RB, GATA1, RBM15, TRIB1
7MP:00053877.2TRIB1, RBM15, GATA1, CSF2RB, IL11RA, GFI1B

Publications for Megakaryocytic Leukemia

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Articles related to Megakaryocytic Leukemia:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Acute megakaryocytic leukemia is associated with worse outcomes than other types of acute myeloid leukemia. (25498456)
2014
2
Extramedullary Tumor of Cerebral Falx: An Unusual Presentation of Acute Megakaryocytic Leukemia. (24663070)
2014
3
Case study interpretation-New Orleans: case 1. Extramedullary acute megakaryocytic leukemia. (23283835)
2013
4
Overexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytic Leukemia. (23874683)
2013
5
Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia. (22294728)
2012
6
A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy. (22110660)
2011
7
A rare case of GATA1 negative chemoresistant acute megakaryocytic leukemia in an 8-month-old infant with trisomy 21. (20108342)
2010
8
Hypercalcemia in pediatric acute megakaryocytic leukemia: case report and review of the literature. (19415024)
2009
9
The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy. (18094719)
2008
10
Distinct clones are associated with the development of transient myeloproliferative disorder and acute megakaryocytic leukemia in a patient with Down syndrome. (17988992)
2007
11
Massive periosteal reaction a presenting feature of acute megakaryocytic leukemia. (18045316)
2007
12
JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. (16037387)
2005
13
Inhibition by Rho-kinase and protein kinase C of myosin phosphatase is involved in thrombin-induced shape change of megakaryocytic leukemia cell line UT-7/TPO. (15567063)
2005
14
Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. (15317736)
2004
15
Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis. (15307108)
2004
16
Transcriptional regulation of the cystathionine-beta -synthase gene in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines. (12393509)
2003
17
Acute megakaryocytic leukemia presenting as hypercalcemia with skeletal lytic lesions. (12225399)
2002
18
Criteria for diagnosis of acute megakaryocytic leukemia. (11263442)
2001
19
Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience. (11001891)
2000
20
Hepatic involvement by congenital megakaryocytic leukemia in a neonate: sonographic features. (10511179)
1999
21
Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines. (10340400)
1999
22
I-131 localization in acute megakaryocytic leukemia. (8957609)
1996
23
Urticarial vasculitis as clinical presentation of megakaryocytic leukemia. (19078105)
1996
24
IL-3 and ribavirin induce differentiation and growth suppression during long-term treatment of a megakaryocytic leukemia cell line. (7593232)
1995
25
Association between Lyn protein tyrosine kinase (p53/56lyn) and the beta subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human megakaryocytic leukemia cell line (M-07e). (7636265)
1995
26
IL-3 and ribavirin induce high level expression of megakaryocytic markers and messages during long-term treatment of a megakaryocytic leukemia cell line. (8021297)
1994
27
Phenotypic characteristics of acute megakaryocytic leukemia and transient abnormal myelopoiesis. (8069184)
1994
28
Expression of platelet alpha-granule proteins in a human megakaryocytic leukemia cell line (CMK 11-5). (7693024)
1993
29
Human stem cell factor (c-kit ligand) induces an autocrine loop of growth in a GM-CSF-dependent megakaryocytic leukemia cell line. (7678880)
1993
30
Induction of smg p21/rap1A p21/krev-1 p21 gene expression during phorbol ester-induced differentiation of a human megakaryocytic leukemia cell line. (1549353)
1992
31
Ultrastructural analysis of platelet-like particles from a human megakaryocytic leukemia cell line (CMK 11-5). (1391807)
1992
32
Modulation of GM-CSF receptor beta-subunit and interleukin-6 receptor mRNA expression in a human megakaryocytic leukemia cell line. (1290964)
1992
33
The translocation t(1;22)(p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children. (1596573)
1992
34
Expression of CD56/NCAM on hematopoietic malignant cells. A useful marker for acute monocytic and megakaryocytic leukemias. (1721853)
1991
35
Different expression of CD36 antigen molecule on the surface of megakaryocyte lineage leukemias and megakaryocyte leukemia cell lines MEG-01 and HEL. (1695706)
1990
36
Cytosolic calcium mobilization and thromboxane synthesis in a human megakaryocytic leukemia cell. (2108872)
1990
37
Acute megakaryocytic leukemia. (2593724)
1989
38
Evidence for clonal development and stem cell origin of M7 megakaryocytic leukemia. (3374169)
1988
39
Flow cytometry shows recurrent aneuploid clone after remission in megakaryocytic leukemia. (3195626)
1988
40
Acute megakaryocytic leukemia with myeloid/monocytic differentiation. (3674284)
1987
41
Megakaryocytic leukemia--its basic and clinical aspects. Proceedings of the Study Group on Megakaryocytic Leukemia and Its Related Diseases. August 26, 1986. (3613389)
1987
42
Acute megakaryocytic leukemia. Flow cytometric analysis of DNA content at diagnosis and during the course of therapy. (3664428)
1987
43
Initial characterization of a human megakaryocytic leukemia cell line, EST-IU. (3725784)
1986
44
Acute megakaryocytic leukemia following chemotherapy for a malignant teratoma. (6198998)
1984
45
Megakaryocytic leukemia in a dog. (567874)
1978
46
Acute megakaryocytic leukemia. Description of a case initially seen as preleukemia syndrome. (565623)
1978
47
Aleukemic megakaryocytic leukemia. (14412375)
1960
48
A case of thrombocythemia; megakaryocytic leukemia]. (13477900)
1957
49
Three cases of megakaryocytic leukemia. (14789510)
1950
50
Acute megakaryocytic leukemia. (18899024)
1948

Variations for Megakaryocytic Leukemia

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Expression for genes affiliated with Megakaryocytic Leukemia

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Search GEO for disease gene expression data for Megakaryocytic Leukemia.

Pathways for genes affiliated with Megakaryocytic Leukemia

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Pathways related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GATA1, GFI1B
29.5GATA1, CSF2RB
3
Show member pathways
Type III interferon signaling38
9.4CSF2RB, IL11RA

Compounds for genes affiliated with Megakaryocytic Leukemia

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GO Terms for genes affiliated with Megakaryocytic Leukemia

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Cellular components related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:00056679.6GATA1, GFI1B
2nucleusGO:00056347.5TRIB1, RBM15, GATA1, GFI1B, MKL1

Biological processes related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:00324969.3TRIB1, CSF2RB

Molecular functions related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor bindingGO:00010859.5GATA1, GFI1B
2transcription regulatory region sequence-specific DNA bindingGO:00009769.4GATA1, MKL1
3protein bindingGO:00055157.9RBM15, GATA1, CSF2RB, GFI1B, MKL1

Products for genes affiliated with Megakaryocytic Leukemia

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Sources for Megakaryocytic Leukemia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet