AMKL
MCID: MGK001
MIFTS: 57

Megakaryocytic Leukemia (AMKL) malady

Blood diseases, Cancer diseases categories

Summaries for Megakaryocytic Leukemia

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers.

MalaCards: Megakaryocytic Leukemia, also known as acute megakaryoblastic leukemia, is related to leukemia and acute leukemia. An important gene associated with Megakaryocytic Leukemia is MKL1 (megakaryoblastic leukemia (translocation) 1), and among its related pathways are C-MYB transcription factor network and Platelet activation, signaling and aggregation. The compounds Sargramostim and ara-ctp have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and myeloid, and related mouse phenotypes are integument and endocrine/exocrine gland.

Aliases & Classifications for Megakaryocytic Leukemia

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Sources:
8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 42NIH Rare Diseases, 48Orphanet, 60UMLS, 9diseasecard, 46OMIM, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
acute megakaryoblastic leukemia:
Prevalence: <1/1000000; Age of onset: Childhood


Aliases & Descriptions:

megakaryocytic leukemia 8 10 30
acute megakaryoblastic leukemia 8 42 48
megakaryoblastic leukemia, acute 9 46
acute megakaryocytic leukemias 8 60
megakaryocytic leukemia without mention of remission 8
acute megakaryoblastic leukemia, morphology 8
acute megakaryoblastic leukaemia, fab m7 8
acute megakaryoblastic leukemia, fab m7 8
acute myeloblastic leukemia type 7 48
megakaryoblastic leukemia acute 44
megakaryocytic myelosis 8
thrombocytic leukaemia 8
amkl 48


External Ids:

Disease Ontology8 DOID:8761
MeSH34 D007947
NCIt39 C3170
ICD9CM27 207.2
ICD10 via Orphanet26 C94.2

Related Diseases for Megakaryocytic Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Megakaryocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.6IL3RA, CSF1R, GATA1, ITGA2B, MKL1, CBS
2acute leukemia31.4IL3RA, IL3, GATA1, CSF1R
3down syndrome30.7ETS2, CBS, GATA1
4myelofibrosis30.6GATA1, IL3
5myeloid leukemia30.3CSF1R, GATA1, IL3, IL3RA
6childhood leukemia10.5
7acute myeloblastic leukemia type 710.5
8adult syndrome10.3
9acute megakaryoblastic leukemia without down syndrome10.3
10acute megakaryoblastic leukemia in down syndrome10.3
11acute monocytic leukemia10.2
12hypercalcemia10.2
13monocytic leukemia10.2
14bone fracture10.2
15klinefelter's syndrome10.2
16xeroderma pigmentosum10.2
17gingival hypertrophy10.2
18gingivitis10.2
19lymphoid leukemia10.1
20acute myeloid leukemia10.1
21diabetes insipidus10.1
22neonatal leukemia10.1
23beckwith-wiedemann syndrome10.1
24chronic myeloid leukemia10.1
25hepatitis a10.1
26hepatitis10.1
27malignant teratoma10.1
28mediastinitis10.1
29osteosclerosis10.1
30periostitis10.1
31pneumonia10.1
32sarcoma10.1
33vasculitis10.1
34asthma10.0IL3
35prostate cancer10.0ETS2
36herpes simplex10.0GATA1
37leukemoid reaction10.0GATA1, IL3
38antiphospholipid syndrome10.0PF4
39intermediate coronary syndrome10.0ITGA2B
40hemorrhagic thrombocythemia10.0GATA1, PF4, IL3
41deficiency anemia10.0CSF1R, GATA1, IL3
42myelodysplastic syndromes10.0CSF1R, GATA1, IL3
43myeloproliferative disorder10.0IL3, PF4, GATA1
44arthritis10.0CSF1R
45ovarian cancer10.0IL3, ETS2, CSF1R
46thrombocytopenia10.0IL3, PF4, ITGA2B, GATA1
47acute erythroid leukemia10.0GATA1, ITGA2B, PF4, IL3
48acute lymphocytic leukemia10.0CSF1R, GATA1, IL3, IL3RA
49adenoma10.0IL11RA, ETS2
50glanzmann's thrombasthenia10.0PF4, ITGA2B

Graphical network of the top 20 diseases related to Megakaryocytic Leukemia:



Diseases related to megakaryocytic leukemia

Clinical Features for Megakaryocytic Leukemia

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Drugs & Therapeutics for Megakaryocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Megakaryocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Megakaryocytic Leukemia

Search NIH Clinical Center for Megakaryocytic Leukemia

Search CenterWatch for Megakaryocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Megakaryocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Megakaryocytic Leukemia

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Anatomical Context for Megakaryocytic Leukemia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Megakaryocytic Leukemia:

32
Bone, Bone marrow, Myeloid, Monocytes, Liver

Animal Models for Megakaryocytic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Megakaryocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.8SPEN, GFI1B, ETS2, CBS, MKL1, GATA1
2MP:00053799.6CSF1R, MKL1, CBS, ETS2, IL3
3MP:00053859.6GATA1, PIK3CD, ITGA2B, MKL1, CBS, ETS2
4MP:00053879.3CSF1R, CSF2RB, GATA1, BST2, PIK3CD, RBM15
5MP:00053769.3PIK3CD, GATA1, CSF2RB, CSF1R, TUBB1, ITGA2B
6MP:00107689.2CSF1R, GATA1, RBM15, NFYA, MKL1, CBS
7MP:00053979.2SPEN, TUBB1, CSF1R, CSF2RB, GATA1, BST2
8MP:00053849.2RBM15, PIK3CD, BST2, GATA1, CSF2RB, CSF1R

Publications for Megakaryocytic Leukemia

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Sources:
50PubMed
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Articles related to Megakaryocytic Leukemia:

(show top 50)    (show all 140)
idTitleAuthorsYear
1
Case study interpretation-New Orleans: case 1. Extramedullary acute megakaryocytic leukemia. (23283835)
2013
2
Overexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytic Leukemia. (23874683)
2013
3
Megakaryocytic leukemia 1 (MKL1) ties the epigenetic machinery to hypoxia-induced transactivation of endothelin-1. (23625963)
2013
4
MYC accelerates p21CIP-induced megakaryocytic differentiation involving early mitosis arrest in leukemia cells. (21769863)
2012
5
A rare case of GATA1 negative chemoresistant acute megakaryocytic leukemia in an 8-month-old infant with trisomy 21. (20108342)
2010
6
Megakaryocytic blast crisis in a chronic myeloid leukemia patient with a rare variant of Philadelphia rearrangement t(9;22;22) and a constitutional translocation t(3;7). (20417868)
2010
7
Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line. (19786835)
2009
8
RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia. (19638627)
2009
9
The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy. (18094719)
2008
10
Membrane type sialidase inhibits the megakaryocytic differentiation of human leukemia K562 cells. (18339327)
2008
11
Chronic megakaryocytic leukemia, misnamed chronic idiopathic myelofibrosis, has neoplastic not hyperplastic megakaryocytopoiesis. (17916755)
2007
12
Segregation of megakaryocytic or erythroid cells from a megakaryocytic leukemia cell line (JAS-R) by adhesion during culture. (17383723)
2007
13
Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia. (16249385)
2006
14
The role of GATA1 mutation in acute megakaryocytic leukemia]. (17176883)
2006
15
TEL/ETV6 accelerates erythroid differentiation and inhibits megakaryocytic maturation in a human leukemia cell line UT-7/GM. (15958056)
2005
16
Inhibition by Rho-kinase and protein kinase C of myosin phosphatase is involved in thrombin-induced shape change of megakaryocytic leukemia cell line UT-7/TPO. (15567063)
2005
17
Is it chronic idiopathic myelofibrosis, myelofibrosis with myeloid metaplasia, chronic megakaryocytic-granulocytic myelosis, or chronic megakaryocytic leukemia? Further thoughts on the nosology of the clonal myeloid disorders. (15902283)
2005
18
Reconstitution of erythroid, megakaryocyte and myeloid hematopoietic support function with neutralizing antibodies against IL-4 and TGFbeta1 in long-term bone marrow cultures infected with LP-BM5 murine leukemia virus. (15869820)
2005
19
Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis. (15307108)
2004
20
Transcriptional regulation of the cystathionine-beta -synthase gene in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines. (12393509)
2003
21
Thrombopoietin, interleukin-11, and early-acting megakaryocyte growth factors in human myeloid leukemia cells. (11426619)
2000
22
The role of p53 in megakaryocyte differentiation and the megakaryocytic leukemias of Down syndrome. (10616523)
2000
23
The effects of arsenic trioxide (As2O3) on human megakaryocytic leukemia cell lines. With a comparison of its effects on other cell lineages. (10811458)
2000
24
Hepatic involvement by congenital megakaryocytic leukemia in a neonate: sonographic features. (10511179)
1999
25
Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines. (10340400)
1999
26
Expression and function of the megakaryocyte growth and development factor receptor in acute myeloid leukemia blasts. (9711904)
1998
27
Effects of thrombopoietin on megakaryocyte colony formation from leukemic cells at diagnosis and from marrow cells after induction chemotherapy for acute leukemias. (9760150)
1998
28
Regulation of both erythroid and megakaryocytic differentiation of a human leukemia cell line, UT-7. (9587401)
1998
29
Increased methotrexate polyglutamylation in acute megakaryocytic leukemia (M7) compared to other subtypes of acute myelocytic leukemia. (9177445)
1997
30
I-131 localization in acute megakaryocytic leukemia. (8957609)
1996
31
Herbimycin A inhibits phorbol ester-induced morphologic changes, adhesion, and megakaryocytic differentiation of the leukemia cell line, MEG-01. (7539928)
1995
32
IL-3 and ribavirin induce high level expression of megakaryocytic markers and messages during long-term treatment of a megakaryocytic leukemia cell line. (8021297)
1994
33
Expression of platelet alpha-granule proteins in a human megakaryocytic leukemia cell line (CMK 11-5). (7693024)
1993
34
Induced megakaryocytic maturation of the human leukemia cell line UT-7 results in down-modulation of erythropoietin receptor gene expression. (8439961)
1993
35
Ultrastructural analysis of a human megakaryocytic leukemia cell line (CMK11-5) in response to platelet agonists. (8477065)
1993
36
Ultrastructural analysis of a human megakaryocytic leukemia cell line (CMK11-5) following prostaglandin E1 stimulation. (8148497)
1993
37
Acute megakaryocytic leukemia with the t(1;22)(p13;q13). (8220150)
1993
38
Induction of smg p21/rap1A p21/krev-1 p21 gene expression during phorbol ester-induced differentiation of a human megakaryocytic leukemia cell line. (1549353)
1992
39
Ultrastructural analysis of platelet-like particles from a human megakaryocytic leukemia cell line (CMK 11-5). (1391807)
1992
40
The translocation t(1;22)(p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children. (1596573)
1992
41
Expression of the heparin-binding growth factor receptor genes in human megakaryocytic leukemia cells. (1311927)
1992
42
Acute megakaryocytic leukemia (AMKL) with major myelofibrosis in an infant. Diagnosis by liver biopsy and response to treatment. (1945824)
1991
43
Platelet factor 4 gene expression in a human megakaryocytic leukemia cell line (CMK) and its differentiated subclone (CMK11-5). (1893970)
1991
44
Megakaryocytic leukemia cell lines and megakaryocytic leukemia]. (2381077)
1990
45
Distribution of cell surface glycoprotein CD9 (P24) antigen on megakaryocyte lineage leukemias and cell lines. (2389771)
1990
46
Flow cytometry shows recurrent aneuploid clone after remission in megakaryocytic leukemia. (3195626)
1988
47
Acute megakaryocytic leukemia. Flow cytometric analysis of DNA content at diagnosis and during the course of therapy. (3664428)
1987
48
Histopathological analysis of cases of megakaryocytic leukemia. (3475495)
1987
49
Recent advances in the study of megakaryocytic leukemia. (3915407)
1985
50
Aleukemic megakaryocytic leukemia. (14412375)
1960

Genetic Variations for Megakaryocytic Leukemia

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Expression for genes affiliated with Megakaryocytic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Megakaryocytic Leukemia

Search GEO for disease gene expression data for Megakaryocytic Leukemia.

Pathways for genes affiliated with Megakaryocytic Leukemia

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Sources:
37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG, 12EMD Millipore
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Pathways related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ETS2, GATA1, CSF1R
2
Hide members
10.1TUBB1, GATA1, ITGA2B, PF4
3
Hide members
10.0CSF2RB, PIK3CD, IL3, IL3RA
4
Hide members
10.0CSF2RB, PIK3CD, IL3, IL3RA
5
Immune response IL-2 activation and signaling pathway
Hide members
10.0IL3RA, IL3, PIK3CD, CSF2RB
6
Hide members
10.0IL3RA, IL3, PIK3CD, CSF2RB
7
Hide members
10.0IL3RA, IL3, CSF2RB, CSF1R
8
Hide members
10.0CSF2RB, ETS2, IL3, IL3RA
99.9CSF2RB, GATA1, PIK3CD, IL3, IL3RA
109.9CSF2RB, PIK3CD, IL3, IL11RA, IL3RA
11
Hide members
9.9CSF1R, CSF2RB, ITGA2B, IL11RA, IL3RA
129.9IL3RA, IL11RA, IL3, ITGA2B, CSF1R
139.9CSF1R, PIK3CD, ITGA2B, IL3, IL3RA
14
Hide members
9.8CSF1R, CSF2RB, PF4, IL3, IL11RA, IL3RA
15
Hide members
9.7CSF1R, CSF2RB, ITGA2B, PF4, IL3, IL11RA
16
Hide members
9.7TUBB1, IL3RA, IL11RA, IL3, PF4, CSF2RB
17
Hide members
9.5TUBB1, CSF1R, CSF2RB, ITGA2B, ETS2, PF4

Compounds for genes affiliated with Megakaryocytic Leukemia

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Sources:
11DrugBank, 44Novoseek, 24HMDB, 49PharmGKB
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Compounds related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1Sargramostim1110.5IL3RA, CSF2RB
2ara-ctp4410.4IL3, CBS
3aclarubicin4410.4IL3, GATA1
4thromboxane44 2411.4PF4, CBS, GATA1
5cytarabine44 49 1112.3CSF1R, GATA1, CBS, IL3
611-dehydrothromboxane b24410.3PF4, CBS
7tirofiban44 1111.2PF4, ITGA2B
8agar4410.2CSF1R, ETS2, PF4, IL3
9hydroxyurea44 49 1112.2GATA1, PF4, IL3
10serine4410.2CSF1R, GATA1, ITGA2B, NFYA, CBS
1112-o-tetradecanoylphorbol 13-acetate4410.1IL3RA, IL3, PF4, ITGA2B, GATA1, CSF1R
12gp 1304410.1IL3RA, IL11RA, IL3
13wortmannin449.7CSF1R, PIK3CD, PF4, IL3

GO Terms for genes affiliated with Megakaryocytic Leukemia

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16Gene Ontology
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Cellular components related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.9IL11RA, MAL, ITGA2B, BST2, CSF2RB, CSF1R

Biological processes related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.3PF4, GATA1
2interleukin-3-mediated signaling pathwayGO:03815610.3IL3RA, CSF2RB
3cellular response to interleukin-3GO:03601610.2IL3RA, CSF2RB
4embryonic hemopoiesisGO:03516210.0IL3, GATA1

Molecular functions related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-3 receptor activityGO:00491210.2IL3RA, CSF2RB
2RNA polymerase II transcription factor bindingGO:0010859.9SPEN, GFI1B, GATA1
3protein bindingGO:0055159.1ITGA2B, RBM15, PIK3CD, BST2, GATA1, NFYA

Products for genes affiliated with Megakaryocytic Leukemia

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  • Antibodies
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Sources for Megakaryocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet