AMKL
MCID: MGK001
MIFTS: 53

Megakaryocytic Leukemia (AMKL) malady

Blood, Cancer categories

Summaries for Megakaryocytic Leukemia

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers.

MalaCards: Megakaryocytic Leukemia, also known as acute megakaryoblastic leukemia, is related to acute leukemia and acute erythroid leukemia. An important gene associated with Megakaryocytic Leukemia is MKL1 (megakaryoblastic leukemia (translocation) 1), and among its related pathways are C-MYB transcription factor network and Platelet activation, signaling and aggregation. The compounds Sargramostim and ara-ctp have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and myeloid, and related mouse phenotypes are integument and endocrine/exocrine gland.

Aliases & Classifications for Megakaryocytic Leukemia

Sources:
8Disease Ontology, 10DISEASES, 31LifeMap Discovery™, 43NIH Rare Diseases, 49Orphanet, 61UMLS, 9diseasecard, 47OMIM, 45Novoseek, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
acute megakaryoblastic leukemia:
Prevalence: <1/1000000; Age of onset: Childhood


Aliases & Descriptions:

megakaryocytic leukemia 8 10 31
acute megakaryoblastic leukemia 8 43 49
megakaryoblastic leukemia, acute 9 47
acute megakaryocytic leukemias 8 61
megakaryocytic leukemia without mention of remission 8
acute megakaryoblastic leukemia, morphology 8
acute megakaryoblastic leukaemia, fab m7 8
acute megakaryoblastic leukemia, fab m7 8
acute myeloblastic leukemia type 7 49
megakaryoblastic leukemia acute 45
megakaryocytic myelosis 8
thrombocytic leukaemia 8
amkl 49


External Ids:

Disease Ontology8 DOID:8761
MeSH35 D007947
NCIt40 C3170
ICD9CM27 207.2
ICD10 via Orphanet26 C94.2

Related Diseases for Megakaryocytic Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Megakaryocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.4IL3RA, IL3, GATA1, CSF1R
2acute erythroid leukemia30.3GATA1, ITGA2B, PF4, IL3
3down syndrome30.3ETS2, CBS, GATA1
4myeloproliferative disorder30.1IL3, PF4, GATA1
5t-cell leukemia10.6
6acute myeloblastic leukemia type 710.5
7acute megakaryoblastic leukemia in down syndrome10.4
8adult syndrome10.4
9acute megakaryoblastic leukemia without down syndrome10.4
10refractory anemia10.4
11acute monocytic leukemia10.2
12acute t cell leukemia10.2
13hypercalcemia10.2
14bone fracture10.2
15klinefelter's syndrome10.2
16xeroderma pigmentosum10.2
17gingival hypertrophy10.2
18b cell deficiency10.2
19t cell deficiency10.2
20acute myeloid leukemia, childhood10.2
21leukemia, acute pre-b-cell10.2
22lymphoid leukemia10.1
23acute myeloid leukemia10.1
24diabetes insipidus10.1
25beckwith-wiedemann syndrome10.1
26chronic myeloid leukemia10.1
27urticaria10.1
28vasculitis10.1
29essential thrombocythemia10.1
30hypoxia10.1
31teratoma10.1
32hematopoietic stem cell transplantation10.1
33acquired central diabetes insipidus10.1
34asthma10.0IL3
35prostate cancer10.0ETS2
36herpes simplex10.0GATA1
37leukemoid reaction10.0GATA1, IL3
38antiphospholipid syndrome10.0PF4
39intermediate coronary syndrome10.0ITGA2B
40hemorrhagic thrombocythemia10.0GATA1, PF4, IL3
41deficiency anemia10.0CSF1R, GATA1, IL3
42myelodysplastic syndromes10.0CSF1R, GATA1, IL3
43arthritis10.0CSF1R
44myeloid leukemia10.0CSF1R, GATA1, IL3, IL3RA
45ovarian cancer10.0IL3, ETS2, CSF1R
46thrombocytopenia10.0IL3, PF4, ITGA2B, GATA1
47myelofibrosis10.0GATA1, IL3
48acute lymphocytic leukemia10.0CSF1R, GATA1, IL3, IL3RA
49adenoma10.0IL11RA, ETS2
50glanzmann's thrombasthenia10.0PF4, ITGA2B

Graphical network of the top 20 diseases related to Megakaryocytic Leukemia:



Diseases related to megakaryocytic leukemia

Clinical Features for Megakaryocytic Leukemia

Drugs & Therapeutics for Megakaryocytic Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Megakaryocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Megakaryocytic Leukemia

Search NIH Clinical Center for Megakaryocytic Leukemia

Search CenterWatch for Megakaryocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Megakaryocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Megakaryocytic Leukemia

Anatomical Context for Megakaryocytic Leukemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Megakaryocytic Leukemia:

33
Liver, Bone marrow, Myeloid, Monocytes, T cells, B cells

Animal Models for Megakaryocytic Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Megakaryocytic Leukemia

Sources:
51PubMed
See all sources

Articles related to Megakaryocytic Leukemia:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Case study interpretation-New Orleans: case 1. Extramedullary acute megakaryocytic leukemia. (23283835)
2013
2
Overexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytic Leukemia. (23874683)
2013
3
Megakaryocytic leukemia 1 (MKL1) ties the epigenetic machinery to hypoxia-induced transactivation of endothelin-1. (23625963)
2013
4
MYC accelerates p21CIP-induced megakaryocytic differentiation involving early mitosis arrest in leukemia cells. (21769863)
2012
5
Congenital acute megakaryocytic leukemia. (22557786)
2011
6
A rare case of GATA1 negative chemoresistant acute megakaryocytic leukemia in an 8-month-old infant with trisomy 21. (20108342)
2010
7
Megakaryocytic blast crisis in a chronic myeloid leukemia patient with a rare variant of Philadelphia rearrangement t(9;22;22) and a constitutional translocation t(3;7). (20417868)
2010
8
Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line. (19786835)
2009
9
Hypercalcemia in pediatric acute megakaryocytic leukemia: case report and review of the literature. (19415024)
2009
10
Unbalanced chromosome 1 abnormalities leading to partial trisomy 1q in four infants with Down syndrome and acute megakaryocytic leukemia. (19228396)
2009
11
The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy. (18094719)
2008
12
Impairment of erythroid and megakaryocytic differentiation by a leukemia-associated and t(9;9)-derived fusion gene product, SET/TAF-Ibeta-CAN/Nup214. (17620317)
2008
13
Massive periosteal reaction a presenting feature of acute megakaryocytic leukemia. (18045316)
2007
14
Inhibition by Rho-kinase and protein kinase C of myosin phosphatase is involved in thrombin-induced shape change of megakaryocytic leukemia cell line UT-7/TPO. (15567063)
2005
15
Hematopoietic stem cell transplantation for de novo acute megakaryocytic leukemia in first complete remission: a retrospective study of the European Group for Blood and Marrow Transplantation (EBMT). (15191953)
2005
16
Arsenic trioxide mediates intrinsic and extrinsic pathways of apoptosis and cell cycle arrest in acute megakaryocytic leukemia. (16010437)
2005
17
Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis. (15307108)
2004
18
Transcriptional regulation of the cystathionine-beta -synthase gene in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines. (12393509)
2003
19
AML1 overexpression and/or mutations should be checked in trisomy 21 patients with megakaryocytic leukemia. (12835737)
2003
20
The clinical and biological significance of megakaryocytic antigen expression in acute myeloid leukemia]. (11498838)
1999
21
Regulation of both erythroid and megakaryocytic differentiation of a human leukemia cell line, UT-7. (9587401)
1998
22
Induction of apoptosis in megakaryocytic leukemia cell lines by MX2, a morpholino anthracycline. (9293905)
1997
23
AML1a but not AML1b inhibits erythroid differentiation induced by sodium butyrate and enhances the megakaryocytic differentiation of K562 leukemia cells. (9056674)
1997
24
Aggressive bone destruction in acute megakaryocytic leukemia: a rare presentation. (8995161)
1997
25
I-131 localization in acute megakaryocytic leukemia. (8957609)
1996
26
IL-3 and ribavirin induce differentiation and growth suppression during long-term treatment of a megakaryocytic leukemia cell line. (7593232)
1995
27
Cytogenetic and molecular analysis of a ring (21) in a patient with partial trisomy 21 and megakaryocytic leukemia. (7573123)
1995
28
IL-3 and ribavirin induce high level expression of megakaryocytic markers and messages during long-term treatment of a megakaryocytic leukemia cell line. (8021297)
1994
29
Expression of platelet alpha-granule proteins in a human megakaryocytic leukemia cell line (CMK 11-5). (7693024)
1993
30
Human stem cell factor (c-kit ligand) induces an autocrine loop of growth in a GM-CSF-dependent megakaryocytic leukemia cell line. (7678880)
1993
31
Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells. (7686791)
1993
32
Induction of smg p21/rap1A p21/krev-1 p21 gene expression during phorbol ester-induced differentiation of a human megakaryocytic leukemia cell line. (1549353)
1992
33
Ultrastructural analysis of platelet-like particles from a human megakaryocytic leukemia cell line (CMK 11-5). (1391807)
1992
34
Acute megakaryocytic leukemia in children. Clinical, immunologic, and cytogenetic findings in two patients. (1833041)
1991
35
Acute megakaryocytic leukemia. (2353967)
1990
36
Acute megakaryocytic leukemia (M7) in children. (2531821)
1989
37
Evidence for clonal development and stem cell origin of M7 megakaryocytic leukemia. (3374169)
1988
38
Flow cytometry shows recurrent aneuploid clone after remission in megakaryocytic leukemia. (3195626)
1988
39
Cure of Curvularia pneumonia by amphotericin B in a patient with megakaryocytic leukemia. (3190400)
1988
40
Translocation t(1;22) in congenital acute megakaryocytic leukemia. (3165702)
1988
41
Acute megakaryocytic leukemia. Flow cytometric analysis of DNA content at diagnosis and during the course of therapy. (3664428)
1987
42
Histopathological analysis of cases of megakaryocytic leukemia. (3475495)
1987
43
Unusual cytogenetic, immunophenotypic and histochemical findings in a case of acute megakaryocytic leukemia. (3126106)
1987
44
Acute myelofibrosis. Immunohistochemical study of four cases and comparison with acute megakaryocytic leukemia. (3314470)
1987
45
Megakaryoblastic leukemia in an infant. Establishment of a megakaryocytic tumor cell line in athymic nude mice. (3719517)
1986
46
Acute megakaryocytic leukemia following chemotherapy for a malignant teratoma. (6198998)
1984
47
Megakaryocytic leukemia; identification utilizing anti-factor VIII immunoperoxidase. (6798857)
1982
48
Acute megakaryocytic leukemia. Description of a case initially seen as preleukemia syndrome. (565623)
1978
49
A case of thrombocythemia; megakaryocytic leukemia]. (13477900)
1957
50
Thrombocythemia in leukemic panmyelosis; megakaryocytic leukemia]. (13477899)
1957

Genetic Variations for Megakaryocytic Leukemia

Expression for genes affiliated with Megakaryocytic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Megakaryocytic Leukemia

Search GEO for disease gene expression data for Megakaryocytic Leukemia.

Pathways for genes affiliated with Megakaryocytic Leukemia

Sources:
38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ETS2, GATA1, CSF1R
2
Hide members
10.1TUBB1, GATA1, ITGA2B, PF4
3
Hide members
10.0CSF2RB, PIK3CD, IL3, IL3RA
4
Hide members
10.0CSF2RB, PIK3CD, IL3, IL3RA
5
Immune response IL-2 activation and signaling pathway
Hide members
10.0IL3RA, IL3, PIK3CD, CSF2RB
6
Hide members
10.0IL3RA, IL3, PIK3CD, CSF2RB
7
Hide members
10.0IL3RA, IL3, CSF2RB, CSF1R
8
Hide members
10.0CSF2RB, ETS2, IL3, IL3RA
99.9CSF2RB, GATA1, PIK3CD, IL3, IL3RA
109.9CSF2RB, PIK3CD, IL3, IL11RA, IL3RA
11
Hide members
9.9CSF1R, CSF2RB, ITGA2B, IL11RA, IL3RA
129.9IL3RA, IL11RA, IL3, ITGA2B, CSF1R
139.9CSF1R, PIK3CD, ITGA2B, IL3, IL3RA
14
Hide members
9.8CSF1R, CSF2RB, PF4, IL3, IL11RA, IL3RA
15
Hide members
9.7CSF1R, CSF2RB, ITGA2B, PF4, IL3, IL11RA
16
Hide members
9.7TUBB1, IL3RA, IL11RA, IL3, PF4, CSF2RB
17
Hide members
9.5TUBB1, CSF1R, CSF2RB, ITGA2B, ETS2, PF4

Compounds for genes affiliated with Megakaryocytic Leukemia

Sources:
11DrugBank, 45Novoseek, 24HMDB, 50PharmGKB
See all sources

Compounds related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1Sargramostim1110.5IL3RA, CSF2RB
2ara-ctp4510.4IL3, CBS
3aclarubicin4510.4IL3, GATA1
4thromboxane45 2411.4PF4, CBS, GATA1
5cytarabine45 50 1112.3CSF1R, GATA1, CBS, IL3
611-dehydrothromboxane b24510.3PF4, CBS
7tirofiban45 1111.2PF4, ITGA2B
8agar4510.2CSF1R, ETS2, PF4, IL3
9hydroxyurea45 50 1112.2GATA1, PF4, IL3
10serine4510.2CSF1R, GATA1, ITGA2B, NFYA, CBS
1112-o-tetradecanoylphorbol 13-acetate4510.1IL3RA, IL3, PF4, ITGA2B, GATA1, CSF1R
12gp 1304510.1IL3RA, IL11RA, IL3
13wortmannin459.7CSF1R, PIK3CD, PF4, IL3

GO Terms for genes affiliated with Megakaryocytic Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.9IL11RA, MAL, ITGA2B, BST2, CSF2RB, CSF1R

Biological processes related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.3PF4, GATA1
2interleukin-3-mediated signaling pathwayGO:03815610.3IL3RA, CSF2RB
3cellular response to interleukin-3GO:03601610.2IL3RA, CSF2RB
4embryonic hemopoiesisGO:03516210.0IL3, GATA1

Molecular functions related to Megakaryocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-3 receptor activityGO:00491210.2IL3RA, CSF2RB
2RNA polymerase II transcription factor bindingGO:0010859.9SPEN, GFI1B, GATA1
3protein bindingGO:0055159.1ITGA2B, RBM15, PIK3CD, BST2, GATA1, NFYA

Products for genes affiliated with Megakaryocytic Leukemia

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  • Lysates
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Sources for Megakaryocytic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet