Megakaryocytic Leukemia malady

Disease Ontology: A leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers.⁶

MalaCards: Megakaryocytic Leukemia, also known as acute megakaryocytic leukemias, is related to acute megakaryoblastic leukemia and down syndrome. An important gene associated with Megakaryocytic Leukemia is MKL1 (megakaryoblastic leukemia (translocation) 1), and among its related pathways are Colorectal cancer and Apoptosis and survival Role of CDK5 in neuronal death and survival. The compounds pge2 and threonine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, monocytes and t cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

megakaryocytic leukemia 6 8 acute megakaryocytic leukemias 6 43 acute megakaryoblastic leukemia, morphology (morphologic abnormality) 6 acute megakaryoblastic leukemia (morphologic abnormality) 6 megakaryocytic leukemia without mention of remission 6 acute megakaryoblastic leukemia, fab m7 (disorder) 6

acute megakaryoblastic leukemia (fab type m7) 6 acute megakaryoblastic leukaemia, fab m7 6 megakaryocytic leukemia (disorder) 6 megakaryocytic myelosis 6 thrombocytic leukaemia 6

Diseases related to megakaryocytic leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 380)

id	Related Disease	Score	Top Affiliating Genes
1	acute megakaryoblastic leukemia	30.1	RBM15, MKL1
2	down syndrome	27.9	NCAM1, KITLG, BST2, MPO, JAK2, CD36
3	megakaryoblastic leukemia	23.6	KITLG, VWF, RBM15, RBM6, MPO, JAK2
4	leukemia	22.7	PIK3CD, NCAM1, KITLG, VWF, RBM15, RBM6
5	acute leukemia	21.1	NCAM1, KITLG, VWF, BCL2, MPO, JAK2
6	macrothrombocytopenia	13.4	CD36, ITGA2B, TUBB1, GATA1
7	joint disorders	13.4	IL11, IL6R, TNFRSF11B
8	leukemoid reaction	13.4	KITLG, IL3, CSF2, GATA1
9	beta thalassemia	13.3	ANXA5, TNFRSF11B, GATA1
10	corneal neovascularization	13.3	CD36, PF4, THBS1
11	dyserythropoietic anemia with thrombocytopenia	13.3	KITLG, IL11, IL3, CSF2
12	pulmonary alveolar proteinosis	13.2	IL3, CASP3, CSF2, CSF2RB
13	pseudoachondroplasia	13.2	CD36, THBS1, ADAMTSL1
14	acute myeloid leukemia, adult	13.2	IL3, TP53
15	aplastic anemia	13.2	KITLG, IL11, IL3, CSF2, GATA1
16	schizophrenia	13.2	IL3, IL3RA, AKT1, CSF2RB
17	protein c deficiency	13.2	JAK2, CBS, PF4, ADAMTSL1
18	acute myelomonocytic leukemia	13.2	MPO, CSF1R, RUNX1
19	arteriosclerosis	13.1	ITGA2B, ANXA5, CBS, PF4, CSF1R, CSF2
20	cerebral malaria	13.1	CD36, THBS1, ADAMTSL1
21	renal osteodystrophy	13.1	CD36, IL11, IL6R, TNFRSF11B
22	myelofibrosis	13.1	JAK2, IL3, TNFRSF11B, GATA1
23	autoimmune thrombocytopenic purpura	13.1	VWF, ITGA2B, IL11, PF4
24	secondary syphilis	13.1	CD36, IL11, IL6R, TNFRSF11B
25	osteoporosis, postmenopausal	13.1	CD36, IL11, TNFRSF11B
26	stem cell leukemia	13.0	MPO, RUNX1, GATA1
27	osteolysis	13.0	CD36, IL11, TNFRSF11B, CSF1R
28	erythrocytosis	13.0	KITLG, JAK2, IL11, IL3
29	blood platelet disease	13.0	VWF, PF4, RUNX1
30	myoepithelioma	13.0	KITLG, TP53, THBS1
31	thrombasthenia	13.0	VWF, ITGA2B, PF4, THBS1
32	von willebrand's disease	13.0	VWF, ITGA2B, IL11, ADAMTSL1
33	glanzmann's thrombasthenia	13.0	VWF, ITGA2B, PF4, THBS1
34	plasmodium falciparum malaria	13.0	KITLG, CD36, IL3, CSF2
35	thrombotic thrombocytopenic purpura, acquired	13.0	VWF, THBS1, ADAMTSL1
36	chronic granulomatous disease	12.9	MPO, AKT1, CSF2
37	periostitis	12.9	CD36, FGFR2, IL11, TNFRSF11B
38	dyskeratosis congenita	12.9	KITLG, IL3, TP53, CSF2
39	skin carcinoma	12.9	TP53, THBS1, CSF2
40	dyskeratosis	12.9	KITLG, IL3, TP53, CSF2
41	nephrosclerosis	12.9	MPO, THBS1, ADAMTSL1
42	factor v leiden thrombophilia	12.8	VWF, ITGA2B, ANXA5, TUBB1, THBS1
43	sm-ahnmd	12.8	PIK3CD, KITLG, MPO, JAK2
44	poems syndrome	12.8	NCAM1, CD36, TNFRSF11B
45	antiphospholipid syndrome	12.8	VWF, ITGA2B, IL3, ANXA5, PF4
46	gliomatosis cerebri	12.7	CDKN1A, FGFR2, TP53
47	hemorrhagic disease	12.7	VWF, CD36, PF4, RUNX1
48	venous thrombosis	12.7	VWF, JAK2, CBS, PF4
49	retinal vein occlusion	12.7	VWF, JAK2, ITGA2B, CBS
50	hairy cell leukemia	12.7	IL3, IL3RA, ANXA5, TP53, CSF1R, CSF2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to megakaryocytic leukemia:

²²

MGI Mouse Phenotypes related to megakaryocytic leukemia:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	GATA1, CSF2RB, CBS
2	endocrine/exocrine gland phenotype	MP:0005379	9.9	CSF1R, OPRK1, FGFR2, MKL1
3	craniofacial phenotype	MP:0005382	9.4	CSF2, CBS, FGFR2, KITLG
4	embryogenesis phenotype	MP:0005380	9.3	GATA1, RUNX1, CSF2, GFI1B, ETS2, CBS
5	reproductive system phenotype	MP:0005389	9.2	CSF2, CSF1R, THBS1, AKT1, CASP3, CBS
6	renal/urinary system phenotype	MP:0005367	8.3	LYN, THBS1, CASP3, CBS, FGFR2, CDKN1A
7	liver/biliary system phenotype	MP:0005370	8.1	GATA1, LYN, RUNX1, TP53, AKT1, CBS
8	hematopoietic system phenotype	MP:0005397	7.6	RBM15, PML, CSF2RB, CSF2, CSF1R, GFI1B
9	immune system phenotype	MP:0005387	7.2	GATA1, LYN, PIK3CD, RUNX1, CSF2RB, CSF2
10	integument phenotype	MP:0010771	7.0	GATA1, RUNX1, CSF2, CSF1R, OPRK1, GFI1B
11	adipose tissue phenotype	MP:0005375	6.7	CSF2, TP53, AKT1, IL6R, FGFR2, CD36
12	skeleton phenotype	MP:0005390	6.7	TNFRSF11B, THBS1, CSF1R, CSF2, RUNX1, GATA1
13	tumorigenesis	MP:0002006	6.7	RUNX1, PML, CSF2, THBS1, TP53, AKT1
14	vision/eye phenotype	MP:0005391	6.5	TP53, CASP3, CBS, FGFR2, CD36, CDKN1A
15	digestive/alimentary phenotype	MP:0005381	6.1	IL11RA, CASP3, TP53, THBS1, OPRK1, LYN
16	growth/size phenotype	MP:0005378	5.8	AKT1, TP53, TNFRSF11B, THBS1, CSF1R, CSF2
17	mortality/aging	MP:0010768	4.7	TP53, TNFRSF11B, PPP1R12A, NFYA, GFI1B, CSF1R
18	cardiovascular system phenotype	MP:0005385	4.6	TP53, AKT1, ETS2, CASP3, TNFRSF11B, GFI1B
19	homeostasis/metabolism phenotype	MP:0005376	3.4	ETS2, AKT1, TUBB1, TP53, PF4, GFI1B
20	cellular phenotype	MP:0005384	3.3	GATA1, FGFR2, MKL1, ITGA2B, CD36, CDKN1A

Articles related to megakaryocytic leukemia:

(show all 29)

id	Title	Authors	Year	Affiliating Genes
1	RUNX1 regulates phosphoinositide 3-kinase/AKT pathway : role in chemotherapy sensitivity in acute megakaryocytic leukemia. (19638627)	Edwards H.... Ge Y.	2009	AKT1, PIK3CD, RUNX1
2	The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy. (18094719)	Ge Y.... Taub J.W.	2008	GATA1, ETS2
3	The role of GATA1 mutation in acute megakaryocytic leukemia (17176883)	Ito E.	2006	GATA1
4	Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia. (16249385)	Ge Y.... Taub J.W.	2006	GATA1, BST2
5	JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. (16037387)	Jelinek J.... Issa J.P.	2005	JAK2
6	Inhibition by Rho-kinase and protein kinase C of myosin phosphatase is involved in thrombin-induced shape change of megakaryocytic leukemia cell line UT-7/TPO. (15567063)	Yazaki A.... Nishikawa M.	2005	PPP1R12A
7	GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia. (15687366)	Ge Y.... Taub J.W.	2005	GATA1
8	Arsenic trioxide mediates intrinsic and extrinsic pathways of apoptosis and cell cycle arrest in acute megakaryocytic leukemia. (16010437)	Lam H.K.... Yuen P.M.	2005	CASP3, ANXA5
9	Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. (15317736)	Taub J.W.... Crispino J.D.	2004	GATA1
10	Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis. (15307108)	Sato T.... Niitsu Y.	2004	TNFRSF11B, IL11
11	Transcriptional regulation of the cystathionine-beta -synthase gene in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines. (12393509)	Ge Y.... Taub J.W.	2003	CBS, NFYA
12	AML1 overexpression and/or mutations should be checked in trisomy 21 patients with megakaryocytic leukemia. (12835737)	Huret J.L.... LAconard C.	2003	RUNX1
13	Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. (11344311)	Mercher T.... Bernard O.A.	2001	MKL1, RBM15
14	Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience. (11001891)	Tallman M.S.... Rowe J.M.	2000	MPO
15	The role of p53 in megakaryocyte differentiation and the megakaryocytic leukemias of Down syndrome. (10616523)	Malkin D.... Zipursky A.	2000	TP53
16	The effects of arsenic trioxide (As2O3) on human megakaryocytic leukemia cell lines. With a comparison of its effects on other cell lineages. (10811458)	Alemany M.... Levin J.	2000	BCL2, PML
17	IL-3 and ribavirin induce differentiation and growth suppression during long-term treatment of a megakaryocytic leukemia cell line. (7593232)	Majumdar A.... Seidman M.M.	1995	IL3
18	Association between Lyn protein tyrosine kinase (p53/56lyn) and the beta subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human megakaryocytic leukemia cell line (M-07e). (7636265)	Li Y.... Chen B.	1995	LYN, CSF1R, CSF2RB
19	IL-3 and ribavirin induce high level expression of megakaryocytic markers and messages during long-term treatment of a megakaryocytic leukemia cell line. (8021297)	Majumdar A.... Seidman M.M.	1994	IL3
20	Expression of platelet alpha-granule proteins in a human megakaryocytic leukemia cell line (CMK 11-5). (7693024)	Hamamoto K.... Sato T.	1993	VWF, THBS1, ADAMTSL1
21	Human stem cell factor (c-kit ligand) induces an autocrine loop of growth in a GM-CSF-dependent megakaryocytic leukemia cell line. (7678880)	Kiss C.... Santoli D.	1993	KITLG, IL3, CSF2
22	Induction of smg p21/rap1A p21/krev-1 p21 gene expression during phorbol ester-induced differentiation of a human megakaryocytic leukemia cell line. (1549353)	Adachi M.... Kaibuchi K.	1992	CDKN1A
23	Megakaryocytic leukemia and platelet factor 4. (1337850)	Ryo R.... Yamaguchi N.	1992	PF4
24	Modulation of GM-CSF receptor beta-subunit and interleukin-6 receptor mRNA expression in a human megakaryocytic leukemia cell line. (1290964)	Yasunaga M.... Yamaguchi N.	1992	IL6R, IL3, IL3RA
25	Expression of the heparin-binding growth factor receptor genes in human megakaryocytic leukemia cells. (1311927)	Katoh O.... Terada M.	1992	FGFR2
26	Platelet factor 4 gene expression in a human megakaryocytic leukemia cell line (CMK) and its differentiated subclone (CMK11-5). (1893970)	Adachi M.... Yamaguchi N.	1991	ITGA2B, PF4
27	Expression of CD56/NCAM on hematopoietic malignant cells. A useful marker for acute monocytic and megakaryocytic leukemias. (1721853)	Ikushima S.... Imashuku S.	1991	NCAM1
28	Different expression of CD36 antigen molecule on the surface of megakaryocyte lineage leukemias and megakaryocyte leukemia cell lines MEG-01 and HEL. (1695706)	Imamura N.... Kuramoto A.	1990	CD36
29	Megakaryocytic leukemia cell lines and megakaryocytic leukemia (2381077)	Ryo R.... Yamaguchi N.	1990	PF4, ADAMTSL1

Genes related to megakaryocytic leukemia according to GeneCards:

(show all 44)

id	Symbol	Description	Score	GeneCards Section Context
1	MKL1	megakaryoblastic leukemia (translocation) 1	11.1	Summaries, Publications
2	BST2	bone marrow stromal cell antigen 2	11.0	Publications
3	IL3RA	interleukin 3 receptor, alpha (low affinity)	11.0	Publications
4	GATA1	GATA binding protein 1 (globin transcription factor 1)	11.0	Publications
5	GFI1B	growth factor independent 1B transcription repressor	11.0	Expressions
6	IL11RA	interleukin 11 receptor, alpha	11.0	Expressions
7	NFYA	nuclear transcription factor Y, alpha	11.0	Publications
8	CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	11.0	Publications
9	ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	11.0	Publications
10	RBM15	RNA binding motif protein 15	11.0	Publications
11	PF4	platelet factor 4	11.0	Publications
12	ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	11.0	Publications
13	ST7L	suppression of tumorigenicity 7 like	11.0	Disorders
14	NSUN5	NOP2/Sun domain family, member 5	11.0	Publications
15	TUBB1	tubulin, beta 1 class VI	11.0
16	PML	promyelocytic leukemia	11.0	Publications
17	THBS1	thrombospondin 1	11.0	Publications
18	IL6R	interleukin 6 receptor	11.0	Publications
19	PPP1R12A	protein phosphatase 1, regulatory subunit 12A	11.0	Publications
20	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	11.0	Publications
21	IL11	interleukin 11	11.0	Publications
22	RBM6	RNA binding motif protein 6	11.0
23	CSF1R	colony stimulating factor 1 receptor	11.0	Publications
24	CBS	cystathionine-beta-synthase	11.0	Publications
25	OPRK1	opioid receptor, kappa 1	11.0
26	KITLG	KIT ligand	11.0	Publications
27	ANXA5	annexin A5	11.0	Publications
28	RUNX1	runt-related transcription factor 1	11.0	Publications
29	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
30	ADAMTSL1	ADAMTS-like 1	11.0	Publications
31	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
32	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	11.0	Publications
33	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
34	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications
35	AKT1	v-akt murine thymoma viral oncogene homolog 1	11.0	Publications
36	JAK2	Janus kinase 2	11.0	Publications
37	VWF	von Willebrand factor	11.0	Publications
38	FGFR2	fibroblast growth factor receptor 2	11.0	Publications
39	NCAM1	neural cell adhesion molecule 1	11.0	Publications
40	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
41	MPO	myeloperoxidase	11.0	Publications
42	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
43	TP53	tumor protein p53	11.0	Publications
44	BCL2	B-cell CLL/lymphoma 2	11.0	Publications

Pathways related to megakaryocytic leukemia according to GeneDecks:

(show top 50)    (show all 86)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer20	10.6	PIK3CD
2	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.3	BCL2
3	Fc epsilon RI signaling pathway20	10.3	PIK3CD, LYN
4	Breast Cancer Regulation by Stathmin136	10.1	PPP1R12A, TUBB1, FGFR2
5	Immune response_IL-3 activation and signaling pathway41	9.8	CSF2RB, IL3RA, IL3, JAK2
6	Immune response IL-3 activation and signaling pathway10	9.8	CSF2RB, IL3RA, IL3, JAK2
7	IL-3 Pathway36	9.7	CSF2RB, AKT1, IL3RA, IL3, JAK2
8	Akt Signaling36	9.7	CSF2RB, ITGA2B, IL11, IL11RA, IL6R, AKT1
9	Lymphocyte Signaling3	9.6	GATA1, LYN, RUNX1, GFI1B, KITLG, NCAM1
10	IL-6 Pathway36	9.5	CSF2, PF4, PPP1R12A, AKT1, IL6R, IL3
11	PGC1Alpha Pathway36	9.5	CSF2RB, IL6R, IL3RA, IL3, IL11, BCL2
12	Endothelin-1 Signaling Pathway36	9.5	CSF1R, PF4, CASP3, IL3, IL11, FGFR2
13	ERK Signaling36	9.3	CSF1R, PF4, PPP1R12A, IL3, IL11, FGFR2
14	Development_Thrombopoietin-regulated cell processes41	9.2	AKT1, CDKN1A, JAK2, PIK3CD
15	Tyrosine Kinases / Adaptors3	9.2	LYN, CSF1R, FGFR2, JAK2, KITLG
16	Development Thrombopoietin-regulated cell processes10	9.1	AKT1, CDKN1A, JAK2, PIK3CD
17	PEDF Induced Signaling36	9.1	BCL2, IL11, IL3, AKT1, PF4, CSF2
18	Cytokine-cytokine receptor interaction20	9.1	CSF2RB, CSF2, CSF1R, PF4, TNFRSF11B, IL6R
19	Focal adhesion20	9.1	THBS1, PPP1R12A, AKT1, ITGA2B, BCL2, VWF
20	Jak-STAT signaling pathway20	9.0	CSF2RB, CSF2, AKT1, IL6R, IL3RA, IL3
21	Glucocorticoid Receptor Signaling36	9.0	CDKN1A, IL11, IL3, IL3RA, IL6R, CSF2RB
22	p70S6K Signaling36	9.0	LYN, CSF2RB, AKT1, IL3RA, IL3, FGFR2
23	MAPK Family Pathway36	8.9	CSF2RB, IL6R, IL3RA, IL3, IL11RA, IL11
24	Hematopoietic cell lineage20	8.8	IL3RA, IL6R, CSF1R, CSF2, IL3, IL11RA
25	Immune System38	8.8	PML, CSF2RB, CSF2, IL6R, IL3RA, IL3
26	Chronic myeloid leukemia20	8.8	RUNX1, TP53, AKT1, CDKN1A, PIK3CD
27	Signal transduction PTEN pathway10	8.8	TP53, AKT1, CASP3, CDKN1A, PIK3CD
28	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	8.8	TP53, AKT1, CASP3, BCL2, PIK3CD
29	Small cell lung cancer20	8.8	TP53, AKT1, ITGA2B, BCL2, PIK3CD
30	TGF-Beta Pathway36	8.7	CSF2RB, AKT1, IL6R, IL3RA, IL3, IL11
31	DHA Signaling36	8.7	AKT1, CASP3, IL3, FGFR2, BCL2, KITLG
32	MIF Regulation of Innate Immune Cells36	8.6	CSF2, PF4, TP53, IL3, IL11, BCL2
33	PAK Pathway36	8.6	CSF2, PF4, PPP1R12A, CASP3, IL3, IL11
34	Selected targets of p5310	8.5	BCL2, CDKN1A, TP53, THBS1
35	Rho Family GTPases36	8.5	CSF2, CSF1R, PF4, KITLG, BCL2, ITGA2B
36	Apoptosis20	8.4	CSF2RB, TP53, AKT1, CASP3, IL3RA, IL3
37	Tec Kinases Signaling36	8.3	IL3, IL3RA, IL6R, CSF1R, CSF2RB, IL11RA
38	JNK Pathway36	8.3	CSF1R, TP53, IL6R, IL3RA, IL3, FGFR2
39	JAK-STAT Pathway36	8.2	CSF2RB, CSF1R, AKT1, IL6R, IL3RA, IL3
40	STAT3 Pathway36	8.2	IL6R, PF4, CSF1R, CSF2, CSF2RB, IL3RA
41	p53 Signaling36	8.2	PML, THBS1, TP53, AKT1, CASP3, CDKN1A
42	Prostate cancer20	8.2	TP53, AKT1, FGFR2, CDKN1A, BCL2, PIK3CD
43	Antioxidant Action of Vitamin-C36	8.1	IL6R, PF4, CSF1R, CSF2, CSF2RB, IL3RA
44	p53 Mediated Apoptosis36	8.1	KITLG, BCL2, FGFR2, IL3, CASP3, AKT1
45	Mitochondrial Apoptosis36	8.1	TP53, AKT1, CASP3, IL3, FGFR2, BCL2
46	Cellular Apoptosis Pathway36	8.0	PML, TP53, AKT1, CASP3, IL3, FGFR2
47	Pancreatic Adenocarcinoma36	7.5	CSF1R, TP53, AKT1, IL3, FGFR2, CDKN1A
48	Pathways in cancer20	7.4	TP53, CSF1R, PML, RUNX1, AKT1, CASP3
49	p38 Signaling36	7.3	CASP3, TP53, PF4, CSF1R, CSF2, CSF2RB
50	Molecular Mechanisms of Cancer36	6.6	PF4, CSF1R, CSF2RB, TP53, TUBB1, AKT1

Compounds related to megakaryocytic leukemia according to GeneDecks:

(show top 50)    (show all 203)

id	Compound	Score	Top Affiliating Genes
1	pge232	10.4	TNFRSF11B, PF4
2	threonine32	10.0	CSF1R, IL3RA, FGFR2
3	vincristine32 34 9 9	12.8	ANXA5, CSF2, NCAM1
4	rapamycin32 42	10.6	KITLG, JAK2, AKT1
5	ly29400232	9.5	LYN, THBS1, TNFRSF11B, AKT1, CASP3, ANXA5
6	gp 13032	9.5	IL6R, IL3RA, JAK2, IL3, CSF2, TNFRSF11B
7	phosphatidylserine32 9 9	11.4	THBS1, VWF, BCL2, ADAMTSL1
8	dmso32	9.3	THBS1, GATA1, RUNX1, KITLG, CSF1R, PF4
9	agar32	9.1	THBS1, PF4, AKT1, ETS2, FGFR2, JAK2
10	estrogen32	9.0	ADAMTSL1, VWF, CD36, FGFR2, IL11, THBS1
11	fibrinogen32	9.0	ITGA2B, IL11, IL6R, ANXA5, CBS, PF4
12	cysteine32	8.8	FGFR2, IL11, CASP3, AKT1, PF4, THBS1
13	amifostine32 9 9	10.8	CSF2, IL11, TP53, IL3, KITLG
14	thalidomide32 42 9 9	11.8	IL6R, IL11, FGFR2, TNFRSF11B, THBS1, CSF2
15	cyclosporin a32 42	9.5	ADAMTSL1, THBS1, KITLG, VWF, JAK2, IL11
16	sb 20358032 42	9.3	CDKN1A, BCL2, THBS1, TNFRSF11B, CD36, ANXA5
17	tgf beta132	8.3	CD36, IL11, PF4, THBS1, TNFRSF11B, ADAMTSL1
18	hydroxyurea32 9 9	10.2	CSF2, KITLG, CDKN1A, IL3, TP53, PF4
19	depsipeptide32	8.0	TP53, KITLG, BCL2, CDKN1A, IL3, ANXA5
20	daunorubicin32 9 9	10.0	ANXA5, IL3, CSF2, CD36, MPO, BCL2
21	imatinib32 34 9 9	10.9	JAK2, CDKN1A, IL3, BCL2, KITLG, ANXA5
22	histamine32 18	8.8	IL6R, IL3, IL11, MPO, PF4, CSF2
23	vitamin d32	7.8	CD36, IL3, IL11, CSF1R, CDKN1A, CSF2
24	doxorubicin32 34 9 9	10.7	GATA1, THBS1, TNFRSF11B, TP53, AKT1, CASP3
25	h2o232	7.7	ADAMTSL1, LYN, PML, CSF2, CBS, ANXA5
26	etoposide32 42 9 9	10.5	CSF1R, RUNX1, PF4, TP53, CASP3, AKT1
27	12-o-tetradecanoylphorbol 13-acetate32	7.5	NCAM1, JAK2, CDKN1A, ITGA2B, FGFR2, IL3
28	arsenite32 18	8.4	BCL2, PML, RUNX1, JAK2, CDKN1A, ANXA5
29	pd 98,05932	7.3	CSF2, CSF1R, THBS1, AKT1, ETS2, CASP3
30	heparin32 9 18 9	10.1	VWF, ADAMTSL1, CSF2, TNFRSF11B, IL3, IL11
31	wortmannin32 42	8.0	LYN, CSF2, CSF1R, THBS1, PF4, AKT1
32	paclitaxel32 34 9 9	10.0	KITLG, FGFR2, THBS1, TP53, TUBB1, AKT1
33	actinomycin d32	7.0	BCL2, JAK2, PML, CDKN1A, IL3, ANXA5
34	thymidine32 18	7.9	KITLG, IL3RA, IL3, IL11, FGFR2, JAK2
35	lipid32	6.6	FGFR2, PIK3CD, NCAM1, JAK2, KITLG, IL6R
36	oligonucleotide32	6.5	ADAMTSL1, ETS2, FGFR2, RUNX1, JAK2, CDKN1A
37	genistein32 9 18 9	9.5	LYN, CASP3, AKT1, TNFRSF11B, THBS1, ANXA5
38	phosphatidylinositol32	6.4	IL6R, LYN, ANXA5, CASP3, AKT1, TNFRSF11B
39	dexamethasone32 42 34 9 9	10.4	THBS1, BCL2, JAK2, CD36, IL11, IL3
40	n acetylcysteine32	6.2	BCL2, JAK2, VWF, CDKN1A, CASP3, IL3
41	cisplatin32 34 9 9	9.1	IL3, ANXA5, AKT1, TP53, CSF2, LYN
42	5fluorouracil32	6.0	ANXA5, IL3, IL11, FGFR2, CD36, CDKN1A
43	cytarabine32 34 9 9	8.9	MPO, CDKN1A, CD36, IL11, IL3, ANXA5
44	paraffin32	5.9	CSF1R, MPO, BCL2, VWF, KITLG, CDKN1A
45	butyrate32	5.8	CSF2, CDKN1A, IL11, IL3, IL6R, ANXA5
46	tyrosine32	5.6	CSF1R, CSF2, FGFR2, AKT1, NSUN5, THBS1
47	cycloheximide32	5.5	ADAMTSL1, IL11, CD36, CDKN1A, JAK2, TP53
48	vegf32	3.8	TNFRSF11B, NCAM1, KITLG, VWF, TP53, AKT1
49	serine32	3.1	IL3, IL11, FGFR2, ITGA2B, CD36, CDKN1A
50	retinoic acid32 42 18	5.0	ADAMTSL1, IL6R, IL3, IL11, FGFR2, CD36

Cellular components related to megakaryocytic leukemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nuclear matrix	GO:016363	9.1	JAK2, TP53, GFI1B, PML
2	external side of plasma membrane	GO:009897	8.5	NCAM1, THBS1, ANXA5, ITGA2B, CD36, VWF
3	extracellular space	GO:005615	8.2	CSF2, THBS1, PF4, TNFRSF11B, IL6R, IL3

Biological processes related to megakaryocytic leukemia according to GeneDecks:

(show all 37)

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-3-mediated signaling pathway	GO:038156	10.5	IL3RA, CSF2RB
2	cellular response to interleukin-3	GO:036016	10.4	CSF2RB, IL3RA
3	negative regulation of cytolysis	GO:045918	10.3	CSF2, PF4
4	dendritic cell differentiation	GO:097028	10.3	CSF2, LYN, GATA1
5	positive regulation of mast cell proliferation	GO:070668	10.2	LYN, KITLG
6	regulation of glycoprotein biosynthetic process	GO:010559	10.1	BCL2, GATA1
7	embryonic hemopoiesis	GO:035162	10.1	GATA1, RUNX1, IL3, KITLG
8	positive regulation of tyrosine phosphorylation of Stat3 protein	GO:042517	10.1	JAK2, IL6R, CSF1R
9	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	10.0	JAK2, IL3, CSF2
10	positive regulation of macrophage derived foam cell differentiation	GO:010744	9.8	CSF2, PF4, CD36
11	positive regulation of anti-apoptosis	GO:045768	9.8	GATA1, AKT1, IL6R, CDKN1A
12	peptidyl-tyrosine phosphorylation	GO:018108	9.7	LYN, CSF1R, FGFR2, JAK2
13	B cell homeostasis	GO:001782	9.7	LYN, CASP3, BCL2, PIK3CD
14	cell fate commitment	GO:045165	9.6	PML, CASP3, FGFR2
15	B cell receptor signaling pathway	GO:050853	9.5	LYN, BCL2, PIK3CD
16	cytokine-mediated signaling pathway	GO:019221	9.5	PML, CSF1R, PF4, IL6R, JAK2, NCAM1
17	positive regulation of MAPK cascade	GO:043410	9.5	IL6R, IL11, FGFR2, CD36
18	protein autophosphorylation	GO:046777	9.3	LYN, CSF1R, AKT1, FGFR2, JAK2
19	platelet degranulation	GO:002576	9.3	LYN, THBS1, PF4, ITGA2B, CD36, VWF
20	cell aging	GO:007569	9.1	BCL2, TP53, PML
21	release of cytochrome c from mitochondria	GO:001836	9.1	TP53, CASP3, BCL2
22	anti-apoptosis	GO:006916	9.1	THBS1, AKT1, ANXA5, MKL1, MPO, BCL2
23	positive regulation of cell proliferation	GO:008284	8.9	LYN, CSF2, CSF1R, IL6R, IL3, IL11
24	neuron apoptotic process	GO:051402	8.9	TP53, CASP3, BCL2
25	platelet activation	GO:030168	8.8	LYN, THBS1, PF4, AKT1, IL11, ITGA2B
26	positive regulation of reactive oxygen species metabolic process	GO:2000379	8.8	THBS1, TP53, CD36, CDKN1A
27	cell proliferation	GO:008283	8.8	KITLG, BST2, AKT1, TP53, GFI1B, CSF1R
28	negative regulation of cell growth	GO:030308	8.7	PML, ST7L, TP53, CDKN1A, BCL2, BST2
29	response to gamma radiation	GO:010332	8.7	PML, TP53, BCL2
30	signal transduction	GO:007165	8.6	LYN, CSF2RB, CSF1R, PPP1R12A, TNFRSF11B, AKT1
31	induction of apoptosis by intracellular signals	GO:008629	8.5	BCL2, CDKN1A, CASP3, AKT1, TP53
32	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.4	GATA1, RUNX1, NFYA, PPP1R12A, TP53, AKT1
33	response to DNA damage stimulus	GO:006974	8.4	LYN, TP53, CASP3, CDKN1A, BCL2
34	negative regulation of cell proliferation	GO:008285	8.4	GATA1, LYN, PML, TP53, FGFR2, CDKN1A
35	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.3	KITLG, GATA1, TP53, IL6R, IL3, IL11
36	negative regulation of apoptotic process	GO:043066	7.9	GATA1, CSF2, THBS1, PF4, TP53, AKT1
37	blood coagulation	GO:007596	7.6	GATA1, LYN, THBS1, PF4, TP53, AKT1

Molecular functions related to megakaryocytic leukemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-3 receptor activity	GO:004912	10.2	CSF2RB, IL3RA
2	RNA polymerase II transcription factor binding	GO:001085	9.5	TP53, GFI1B, GATA1
3	cytokine activity	GO:005125	9.1	KITLG, IL11, IL3, TNFRSF11B, CSF2
4	ubiquitin protein ligase binding	GO:031625	8.6	LYN, PML, TP53, CBS, BCL2
5	protein homodimerization activity	GO:042803	8.4	RUNX1, PML, CSF1R, CBS, IL6R, FGFR2
6	protein binding	GO:005515	4.3	GATA1, AKT1, TP53, PPP1R12A, NFYA, GFI1B