MCID: MGS004
MIFTS: 45

Meige Syndrome malady

Categories: Rare diseases, Neuronal diseases, Reproductive diseases, Blood diseases, Oral diseases

Aliases & Classifications for Meige Syndrome

About this section
Sources:
11Disease Ontology, 13DISEASES, 30ICD10 via Orphanet, 38MeSH, 47NIH Rare Diseases, 49Novoseek, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Meige Syndrome:

Name: Meige Syndrome 11 47 53 38 13 67
Meigs Syndrome 53 49 67
Blepharospasm-Oromandibular Dystonia Syndrome 47 53
Meige Dystonia 47 53
Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome 47
Blepharospasm - Oromandibular Dystonia 47
 
Blepharospasm-Oromandibular Dystonia 47
Segmental Cranial Dystonia 47
Demons-Meigs Syndrome 53
Oral Facial Dystonia 47
Brueghel Syndrome 47
Meige's Syndrome 47

Characteristics:

Orphanet epidemiological data:

53
meigs syndrome:
Inheritance: Not applicable; Age of onset: Adult

Classifications:



External Ids:

Disease Ontology11 DOID:3982
MeSH38 D008538
SNOMED-CT61 230325003
ICD10 via Orphanet30 D27, G24.8
UMLS via Orphanet68 C0025184

Summaries for Meige Syndrome

About this section
Disease Ontology:11 A cranio-facial dystonia that is accompanied by blepharospasm.

MalaCards based summary: Meige Syndrome, also known as meigs syndrome, is related to oromandibular dystonia and segmental dystonia, and has symptoms including torticollis, hypokinesia and bradykinesia. An important gene associated with Meige Syndrome is DRD5 (Dopamine Receptor D5), and among its related pathways is Heart Development. Affiliated tissues include ovary, brain and colon, and related mouse phenotypes are normal and vision/eye.

Related Diseases for Meige Syndrome

About this section

Diseases in the Meige Syndrome family:

Pseudo-Meigs Syndrome

Diseases related to Meige Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1oromandibular dystonia29.8DRD5, THAP1, TOR1A
2segmental dystonia29.2DRD5, SGCE, THAP1, TOR1A
3cervical dystonia29.0GCH1, SGCE, THAP1, TOR1A
4pseudo-meigs syndrome12.0
5atypical meigs syndrome12.0
6blepharospasm, primary benign10.9
7adie pupil10.4FOXC2, SOX18
8handigodu joint disease10.4FOXC1, FOXC2
9long qt syndrome-1110.3SGCE, TOR1A
10aberrant subclavian artery10.3THAP1, TOR1A
11x-linked dystonia-parkinsonism/lubag10.3THAP1, TOR1A
12hemidystonia10.3THAP1, TOR1A
13miyoshi muscular dystrophy 210.3FOXC2, SOX18
14otitis externa10.2DRD5, KANTR
15lymphoid leukemia10.2FOXC2, GJC2, SOX18
16pediatric infratentorial ependymoma10.2FOXC2, GJC2
17struma ovarii10.2
18gummatous syphilis10.2FOXC1, FOXC2, GJC2
19leiomyoma10.2
20fibroma10.2
21blepharospasm10.1
22thiamine metabolism dysfunction syndrome 210.1GCH1, TOR1A
23multifocal dystonia10.1THAP1, TOR1A
24spasmodic dystonia10.0GCH1, KANTR
25ovarian fibroma10.0
26oculogyric crisis10.0DRD5, GCH1, TOR1A
27miller fisher syndrome10.0ATXN3, SGCE
28dystonia10.0
29cranio-facial dystonia10.0GCH1, THAP1, TOR1A
30retinitis pigmentosa 3110.0FOXC2, SOX18
31peritonitis9.9
32schizophrenia9.8
33systemic lupus erythematosus9.8
34breast cancer9.8
35cystadenoma9.8
36adenocarcinoma9.8
37lupus erythematosus9.8
38ovarian germ cell tumor9.8
39hemifacial spasm9.8
40endotheliitis9.8
41ovarian fibrothecoma9.8
42histiocytoid hemangioma9.8GCH1, KANTR
43extrahepatic bile duct leiomyosarcoma9.8DRD5, GCH1, THAP1, TOR1A
44gastric cancer9.7
45hemangioma9.7
46urinary tract papillary transitional cell benign neoplasm9.7GCH1, SGCE, THAP1, TOR1A
47angiomyolipoma9.6ATXN3, KANTR, TOR1A
48colorectal cancer9.6
49ebstein anomaly9.6
50takayasu arteritis9.6

Graphical network of the top 20 diseases related to Meige Syndrome:



Diseases related to meige syndrome

Symptoms for Meige Syndrome

About this section

UMLS symptoms related to Meige Syndrome:


torticollis, hypokinesia, bradykinesia, clumsiness, fumbling, neonatal dyskinesia, akathisia, posturing, respiratory dyskinesia, cachexia, cancer pain, tumor pain, metastatic pain, breakthrough pain, hepatic hydrothorax

Drugs & Therapeutics for Meige Syndrome

About this section

Drugs for Meige Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Dihydroxyphenylalanine140

Interventional clinical trials:

idNameStatusNCT IDPhase
1Brain Stimulation to Treat Blepharospasm or Meige SyndromeCompletedNCT00411255Phase 2
2The Dystonia Coalition Natural History and Biospecimen Repository for Isolated DystoniasRecruitingNCT01373424

Search NIH Clinical Center for Meige Syndrome


Cochrane evidence based reviews: meige syndrome

Genetic Tests for Meige Syndrome

About this section

Anatomical Context for Meige Syndrome

About this section

MalaCards organs/tissues related to Meige Syndrome:

35
Ovary, Brain, Colon, Breast, Endothelial, Globus pallidus, Uterus

Animal Models for Meige Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Meige Syndrome:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.8DRD5, FOXC1, FOXC2, GJC2, GLI2, SOX18
2MP:00053918.3DRD5, FOXC1, FOXC2, GJC2, GLI2, TOR1A
3MP:00036318.2ATXN3, DRD5, FOXC1, FOXC2, GJC2, GLI2

Publications for Meige Syndrome

About this section

Articles related to Meige Syndrome:

(show top 50)    (show all 259)
idTitleAuthorsYear
1
A case of Meigs' syndrome with preceding pericardial effusion in advance of pleural effusion. (27160723)
2016
2
Long-term survival in pseudo-Meigs' syndrome caused by ovarian metastases from colon cancer. (27842595)
2016
3
Pseudo-Meigs' syndrome secondary to metachronous ovarian metastases from transverse colon cancer. (27182170)
2016
4
Combination therapy for segmental craniocervical dystonia (Meige syndrome) with aripiprazole, trihexyphenidyl, and botulinum toxin: three cases reports. (25151364)
2015
5
A case of mixed connective tissue disease with pseudo-pseudo Meigs' syndrome (PPMS)-like features. (26377236)
2015
6
Massive ascites caused by a large pedunculated subserosal uterine leiomyoma that has feeding arteries from peripheral tissues and exhibits elevated CA125: A case report of atypical Pseudo-Meigs' syndrome. (24359072)
2014
7
Pseudo-Meigs' syndrome secondary to endodermal sinus tumour. (24359073)
2014
8
Long-term botulinum toxin treatment of benign essential blepharospasm, hemifacial spasm, and Meige syndrome. (23541393)
2013
9
Misdiagnosis of gossypiboma as Meigs' syndrome. (23096267)
2013
10
Uterine Angioleiomyoma with Atypia, Raised CA-125 Levels, and Pseudo-Meigs Syndrome: An Alarming Presentation. (22953135)
2012
11
Sudden death associated with Meigs syndrome: an autopsy case report. (20634668)
2012
12
Dementia with lewy bodies in meige syndrome. (22984651)
2012
13
Parasitic fibroid and pseudo-Meigs' syndrome: co-existence of two rare entities. (22519502)
2012
14
Bilateral pallidal deep brain stimulation in primary Meige syndrome. (21147544)
2011
15
Pseudo-Meigs' syndrome caused by a uterine leiomyosarcoma: a new clinical condition. (21625074)
2011
16
Clinical experience of Pseudo-Meigs' Syndrome due to colon cancer. (21912477)
2011
17
Long-term suppression of Meige syndrome after pallidal stimulation: a 10-year follow-up study. (20589876)
2010
18
Struma ovarii associated with hyperthyroidism, elevated CA 125 and pseudo-Meigs syndrome may mimic advanced ovarian cancer. (18618418)
2008
19
Abdominal hypertension in Meigs' syndrome. (17905563)
2008
20
Successful treatment of the Meige syndrome with oral zolpidem monotherapy. (18581473)
2008
21
Cystic struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125 levels. A case report and review of the literature. (18334015)
2008
22
Pseudo-Meigs' syndrome caused by uterine smooth muscle tumor of uncertain malignant potential with low vascular endothelial growth factor expression. (17944915)
2008
23
Struma ovarii with pseudo-Meigs' syndrome and elevated CA125 levels. (17365481)
2007
24
Elevated CA125 level associated with Meigs' syndrome: case report and review of the literature. (16515612)
2006
25
Pseudo-Meigs' syndrome caused by breast cancer metastasis to both ovaries. (17146160)
2006
26
Meigs' syndrome in a young woman with a normal serum CA-125 level. (16265850)
2005
27
Ovarian dysgerminoma associated with Pseudo-Meigs' syndrome and functioning ovarian stroma: a case report. (15863182)
2005
28
Pseudo-Meigs' syndrome associated with malignant struma ovarii: a case report. (15262148)
2004
29
DVT in Meigs' syndrome. (12144916)
2002
30
The role of inflammatory cytokines in Meigs' syndrome. (11975958)
2002
31
Meigs' syndrome with an elevated CA 125 from benign Brenner tumors. (11704231)
2001
32
Cumulative dosage effect of a RAD51L1/HMGA2 fusion and RAD51L1 loss in a case of pseudo-Meigs' syndrome. (11746973)
2001
33
Pseudo-Meigs' syndrome]. (10827530)
2000
34
Pseudo-Meigs syndrome with elevated CA 125 levels. (9645834)
1998
35
Meigs' syndrome and pseudo-Meigs' syndrome. (20894667)
1987
36
Meigs' syndrome and pseudo-Meigs' syndrome. (3585894)
1987
37
Blepharospasm and Meige syndrome: a review of diagnostic, aetiological and treatment approaches. (3920392)
1985
38
Blepharospasm, Meige syndrome, and hemifacial spasm: treatment with botulinum toxin. (4033932)
1985
39
Atypical endometrioid cystadenofibroma with Meigs' syndrome: ultrastructure and S-phase fraction. (7059908)
1982
40
Pseudo-Meigs syndrome with resulting papillary adenocarcinomas of the ovary and fallopian tube. (6109647)
1980
41
Amylase-producing ovarian neoplasm with pseudo-Meigs' syndrome and elevated pleural fluid amylase: case report and ultrastructure. (498043)
1979
42
Lymphangiogram of Meigs' syndrome. Report of a case. (4316584)
1968
43
Meigs' syndrome--an incomplete form with severe hydrothorax. (5910412)
1966
44
Hydrothorax associated with ovarian carcinoma, simulating Meigs' syndrome. Report of two cases. (13917415)
1962
45
Malignant ovarian tumor with ascites and hydrothorax simulating Meigs' syndrome. (13508986)
1958
46
Meigs' syndrome; apparent cardiac manifestations. (13141064)
1953
47
CLINICAL conference on metabolic problems; hypothyroidism and Meigs' syndrome. (13002076)
1952
48
A case of Meigs' syndrome. (14916191)
1952
49
A case of Meigs' syndrome. (18148205)
1949
50
Fibroma of the ovary associated with ascites and hydrothorax (Meigs' syndrome); report of a case and review of the literature. (20275659)
1946

Variations for Meige Syndrome

About this section

Expression for genes affiliated with Meige Syndrome

About this section
Search GEO for disease gene expression data for Meige Syndrome.

Pathways for genes affiliated with Meige Syndrome

About this section

Pathways related to Meige Syndrome according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8FOXC1, FOXC2

GO Terms for genes affiliated with Meige Syndrome

About this section

Biological processes related to Meige Syndrome according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic process involved in outflow tract morphogenesisGO:190225710.5FOXC1, FOXC2
2lymphangiogenesisGO:000194610.5FOXC2, SOX18
3paraxial mesoderm formationGO:004834110.5FOXC1, FOXC2
4regulation of blood vessel sizeGO:005088010.4FOXC1, FOXC2
5cardiac muscle cell proliferationGO:006003810.4FOXC1, FOXC2
6regulation of organ growthGO:004662010.4FOXC1, FOXC2
7artery morphogenesisGO:004884410.4FOXC1, FOXC2
8ventricular cardiac muscle tissue morphogenesisGO:005501010.3FOXC1, FOXC2
9neural crest cell developmentGO:001403210.3FOXC1, FOXC2
10ureteric bud developmentGO:000165710.2FOXC1, FOXC2
11heart morphogenesisGO:000300710.1FOXC1, FOXC2
12lymph vessel developmentGO:000194510.1FOXC1, FOXC2, SOX18
13somitogenesisGO:000175610.1FOXC1, FOXC2
14blood vessel remodelingGO:000197410.0FOXC1, FOXC2
15collagen fibril organizationGO:00301999.9FOXC1, FOXC2
16embryonic heart tube developmentGO:00350509.9FOXC1, FOXC2, SOX18
17intermediate filament cytoskeleton organizationGO:00451049.9ATXN3, TOR1A
18blood vessel developmentGO:00015689.9FOXC1, FOXC2, SOX18
19negative regulation of blood pressureGO:00457769.8DRD5, GCH1
20kidney developmentGO:00018229.7FOXC1, FOXC2, GLI2
21in utero embryonic developmentGO:00017019.7FOXC1, GLI2, SOX18
22skeletal system developmentGO:00015019.5FOXC1, FOXC2, GLI2
23positive regulation of transcription, DNA-templatedGO:00458939.2FOXC1, FOXC2, GLI2, SOX18
24heart developmentGO:00075078.9FOXC1, FOXC2, GLI2, SOX18

Molecular functions related to Meige Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00010779.7FOXC2, GLI2, SOX18
2transcription regulatory region DNA bindingGO:00442128.9FOXC1, FOXC2, GLI2, SOX18
3sequence-specific DNA bindingGO:00435658.7FOXC1, FOXC2, GLI2, SOX18, THAP1

Sources for Meige Syndrome

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet