MCID: MGS004
MIFTS: 50

Meige Syndrome malady

Categories: Rare diseases, Neuronal diseases, Reproductive diseases, Cancer diseases, Oral diseases

Aliases & Classifications for Meige Syndrome

About this section
Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 47Novoseek, 59SNOMED-CT, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Meige Syndrome:

Name: Meige Syndrome 10 45 12 51 36 65
Meigs Syndrome 47 51 65
Blepharospasm-Oromandibular Dystonia Syndrome 45 51
Meige Dystonia 45 51
Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome 45
Blepharospasm - Oromandibular Dystonia 45
 
Blepharospasm-Oromandibular Dystonia 45
Segmental Cranial Dystonia 45
Demons-Meigs Syndrome 51
Oral Facial Dystonia 45
Brueghel Syndrome 45
Meige's Syndrome 45

Characteristics:

Orphanet epidemiological data:

51
meigs syndrome:
Inheritance: Not applicable; Age of onset: Adult

Classifications:



External Ids:

Disease Ontology10 DOID:3982
MeSH36 D008538
Orphanet51 314451, 93964
SNOMED-CT59 230325003
ICD10 via Orphanet28 D27, G24.8
UMLS via Orphanet66 C0025184
UMLS65 C0025183, C0025184

Summaries for Meige Syndrome

About this section
NIH Rare Diseases:45 Meige syndrome is a rare, neurological condition characterized by blepharospasm (abnormal movement of the eyelids); oromandibular dystonia (spasms in the jaw and tongue); and sometimes, cervical dystonia. symptoms and severity can vary. the exact cause of meige syndrome is unknown, but researchers suspect that it is due to a combination of genetic and environmental factors. treatment focuses on each person's symptoms and may include drug therapy and/or botulinum a toxin (botox) injections. other treatment options, such as deep brain stimulation, are currently being considered. last updated: 2/17/2015

MalaCards based summary: Meige Syndrome, also known as meigs syndrome, is related to segmental dystonia and pseudo-meigs syndrome, and has symptoms including hepatic hydrothorax, breakthrough pain and metastatic pain. An important gene associated with Meige Syndrome is DRD5 (Dopamine Receptor D5), and among its related pathways are Heart Development and Folate biosynthesis. Affiliated tissues include brain, tongue and ovary, and related mouse phenotypes are pigmentation and vision/eye.

Disease Ontology:10 A cranio-facial dystonia that is accompanied by blepharospasm.

Related Diseases for Meige Syndrome

About this section

Diseases in the Meige Syndrome family:

Pseudo-Meigs Syndrome

Diseases related to Meige Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1segmental dystonia29.1GCH1, SGCE, THAP1, TOR1A
2pseudo-meigs syndrome12.1
3atypical meigs syndrome12.1
415q13.3 microduplication syndrome10.7FOXC2, SOX18
5weill-marchesani syndrome10.5FOXC2, SOX18
6long qt syndrome-1110.4SGCE, TOR1A
7spastic angina with healthy coronary artery10.4THAP1, TOR1A
8cranio-facial dystonia10.3THAP1, TOR1A
9struma ovarii10.3
10leiomyoma10.3
11miyoshi muscular dystrophy 210.3FOXC2, SOX18
12fibroma10.3
13peptic ulcer disease10.3FOXC2, GJC2
14focal dystonia10.2THAP1, TOR1A
15blepharospasm10.2
16lymphoblastic lymphoma10.2FOXC2, GJC2, SOX18
17oculogyric crisis10.2DRD5, THAP1, TOR1A
18brachydactyly10.2FOXC1, FOXC2, GJC2
19ovarian fibroma10.2
20dystonia10.1
21thiamine metabolism dysfunction syndrome 210.1GCH1, TOR1A
22focal hand dystonia10.0DRD5, GCH1, TOR1A
23hypochondriasis10.0ATXN3, SGCE
24peritonitis10.0
25retinitis pigmentosa 3110.0FOXC2, SOX18
26spasmodic dystonia10.0GCH1, THAP1, TOR1A
27hereditary lymphedema10.0
28central nervous system hereditary degenerative disease10.0GCH1, SGCE, TOR1A
29multifocal dystonia10.0DRD5, SGCE, THAP1, TOR1A
30breast cancer9.9
31cystadenoma9.9
32adenocarcinoma9.9
33ovarian germ cell tumor9.9
34hemifacial spasm9.9
35endotheliitis9.9
36ovarian fibrothecoma9.9
37torsion dystonia with onset in infancy9.9GCH1, THAP1, TOR1A
38schizophrenia9.9
39systemic lupus erythematosus9.9
40hemangioma9.9
41oromandibular dystonia9.9
42lupus erythematosus9.9
43guizar vasquez sanchez manzano syndrome9.8GCH1, PTS
44mediastinum leiomyosarcoma9.7DRD5, GCH1, THAP1, TOR1A
45anismus9.7GCH1, SGCE, THAP1, TOR1A
46sleep apnea9.7GCH1, SGCE, THAP1, TOR1A
47colorectal cancer9.7
48gastric cancer9.7
49hydrocephalus9.7
50cervical dystonia9.7

Graphical network of the top 20 diseases related to Meige Syndrome:



Diseases related to meige syndrome

Symptoms for Meige Syndrome

About this section

UMLS symptoms related to Meige Syndrome:


hepatic hydrothorax, breakthrough pain, metastatic pain, tumor pain, cancer pain, cachexia, respiratory dyskinesia, posturing, akathisia, neonatal dyskinesia, fumbling, clumsiness, bradykinesia, hypokinesia, torticollis

Drugs & Therapeutics for Meige Syndrome

About this section

Drugs for Meige Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Dihydroxyphenylalanine123

Interventional clinical trials:

idNameStatusNCT IDPhase
1Brain Stimulation to Treat Blepharospasm or Meige SyndromeCompletedNCT00411255Phase 2
2The Dystonia Coalition Natural History and Biospecimen Repository for Isolated DystoniasRecruitingNCT01373424

Search NIH Clinical Center for Meige Syndrome


Cochrane evidence based reviews: meige syndrome

Genetic Tests for Meige Syndrome

About this section

Anatomical Context for Meige Syndrome

About this section

MalaCards organs/tissues related to Meige Syndrome:

33
Brain, Tongue, Ovary, Lung, Breast, Prostate, Bone

Animal Models for Meige Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Meige Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.8FOXC1, FOXC2, PTS, SOX18
2MP:00053918.4DRD5, FOXC1, FOXC2, GJC2, GLI2, TOR1A
3MP:00028738.2DRD5, FOXC1, FOXC2, GJC2, GLI2, SOX18
4MP:00053697.9FOXC1, FOXC2, GLI2, PTS, SGCE, TOR1A
5MP:00036316.4ATXN3, DRD5, FOXC1, FOXC2, GJC2, GLI2

Publications for Meige Syndrome

About this section

Articles related to Meige Syndrome:

(show top 50)    (show all 255)
idTitleAuthorsYear
1
A case of Meigs' syndrome with preceding pericardial effusion in advance of pleural effusion. (27160723)
2016
2
Combination therapy for segmental craniocervical dystonia (Meige syndrome) with aripiprazole, trihexyphenidyl, and botulinum toxin: three cases reports. (25151364)
2015
3
Massive ascites caused by a large pedunculated subserosal uterine leiomyoma that has feeding arteries from peripheral tissues and exhibits elevated CA125: A case report of atypical Pseudo-Meigs' syndrome. (24359072)
2014
4
Meigs' syndrome with elevated serum CA 125 level in a case of ovarian fibrothecoma. (25556284)
2014
5
A rare case of bilateral ovarian fibroma presenting as Meigs syndrome. (23919874)
2013
6
A case of schizophrenia with meige syndrome induced by perospirone successfully treated with biperiden. (23487218)
2013
7
Uterine Angioleiomyoma with Atypia, Raised CA-125 Levels, and Pseudo-Meigs Syndrome: An Alarming Presentation. (22953135)
2012
8
Sudden death associated with Meigs syndrome: an autopsy case report. (20634668)
2012
9
A regressive Meigs syndrome after definitive adnexal torsion. (21714950)
2011
10
Bilateral pallidal deep brain stimulation in primary Meige syndrome. (21147544)
2011
11
Pseudo-Meigs' syndrome caused by a uterine leiomyosarcoma: a new clinical condition. (21625074)
2011
12
Meigs' syndrome with elevated serum cancer antigen 125 levels in a case of ovarian sclerosing stromal tumor. (21791307)
2011
13
Meigs' syndrome and virilizing ovarian fibrothecoma complicating pregnancy. A case report and review of the literature. (19675518)
2009
14
Struma ovarii associated with hyperthyroidism, elevated CA 125 and pseudo-Meigs syndrome may mimic advanced ovarian cancer. (18618418)
2008
15
Abdominal hypertension in Meigs' syndrome. (17905563)
2008
16
Ovarian capillary hemangioma presenting as pseudo-Meigs' syndrome: a case report. (17478373)
2007
17
Ovarian sclerosing stromal tumor presenting as Meigs' syndrome with elevated CA-125. (17100828)
2006
18
Pseudo-Meigs' syndrome caused by retroperitoneal tumor in a patient with Ebstein anomaly. (16136373)
2005
19
Meigs' syndrome in a young woman with a normal serum CA-125 level. (16265850)
2005
20
Pseudo-Meigs' syndrome associated with malignant struma ovarii: a case report. (15262148)
2004
21
Pseudo-Meigs' syndrome secondary to subserous myoma uteri: a case report. (12546324)
2002
22
DVT in Meigs' syndrome. (12144916)
2002
23
Pseudo-Meigs' syndrome]. (10827530)
2000
24
Leiomyoblastoma of the colon presenting as pseudo-Meigs' syndrome. (10419722)
1999
25
Pseudo-Meigs syndrome with elevated CA 125 levels. (9645834)
1998
26
Struma ovarii presenting as acute pseudo-Meigs syndrome with an elevated CA 125 level. (8883774)
1996
27
Meigs' syndrome with elevated serum CA 125 levels: two case reports and review of the literature. (8522265)
1995
28
Struma ovarii with pseudo-Meigs' syndrome: report of a case and review of the literature. (7958166)
1994
29
Amylase levels in pleural and peritoneal fluid in Meigs' syndrome. (2447277)
1987
30
Meigs' syndrome and pseudo-Meigs' syndrome. (20894667)
1987
31
Blepharospasm and Meige syndrome: a review of diagnostic, aetiological and treatment approaches. (3920392)
1985
32
Blepharospasm, Meige syndrome, and hemifacial spasm: treatment with botulinum toxin. (4033932)
1985
33
Atypical endometrioid cystadenofibroma with Meigs' syndrome: ultrastructure and S-phase fraction. (7059908)
1982
34
Primary ovarian lymphoma associated with Meigs' syndrome: a case report. (6950626)
1982
35
Pseudo-Meigs syndrome with resulting papillary adenocarcinomas of the ovary and fallopian tube. (6109647)
1980
36
ATYPICAL MEIGS' SYNDROME WITH HYPERTENSION AND ERYTHROCYTOSIS. (14115862)
1964
37
Hydrothorax associated with ovarian carcinoma, simulating Meigs' syndrome. Report of two cases. (13917415)
1962
38
Meigs' syndrome and pathogenesis of pleurisy and polyserositis. (13760748)
1960
39
Meigs' syndrome with report of a case. (13573289)
1958
40
Inoperable case or Meigs' syndrome]. (13296775)
1956
41
A case of Meigs syndrome. (13241376)
1955
42
Meigs' syndrome: a brief review of the condition and report of a case associated with a Brenner tumour. (13160404)
1954
43
Meigs' syndrome. (13011088)
1953
44
CLINICAL conference on metabolic problems; hypothyroidism and Meigs' syndrome. (13002076)
1952
45
A case of Meigs' syndrome. (14916191)
1952
46
Fibro-adenoma of the ovary with ascites and hydrothorax (Meigs' syndrome). (14814476)
1951
47
Meigs' Syndrome; a case report. (14802081)
1951
48
Meigs' syndrome; a report of 3 cases. (14779202)
1950
49
A case of Meigs' syndrome. (18148205)
1949
50

Variations for Meige Syndrome

About this section

Expression for genes affiliated with Meige Syndrome

About this section
Search GEO for disease gene expression data for Meige Syndrome.

Pathways for genes affiliated with Meige Syndrome

About this section

Pathways related to Meige Syndrome according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8FOXC1, FOXC2
29.1GCH1, PTS

GO Terms for genes affiliated with Meige Syndrome

About this section

Biological processes related to Meige Syndrome according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic process involved in outflow tract morphogenesisGO:190225710.5FOXC1, FOXC2
2paraxial mesoderm formationGO:004834110.4FOXC1, FOXC2
3ventricular cardiac muscle tissue morphogenesisGO:005501010.4FOXC1, FOXC2
4collagen fibril organizationGO:003019910.4FOXC1, FOXC2
5neural crest cell developmentGO:001403210.4FOXC1, FOXC2
6regulation of organ growthGO:004662010.4FOXC1, FOXC2
7blood vessel remodelingGO:000197410.4FOXC1, FOXC2
8artery morphogenesisGO:004884410.3FOXC1, FOXC2
9blood vessel developmentGO:000156810.3FOXC1, FOXC2
10somitogenesisGO:000175610.2FOXC1, FOXC2
11embryonic heart tube developmentGO:003505010.0FOXC1, FOXC2, SOX18
12lymph vessel developmentGO:000194510.0FOXC1, FOXC2, SOX18
13skeletal system developmentGO:00015019.8FOXC1, FOXC2
14heart developmentGO:00075079.7FOXC1, FOXC2, SOX18
15in utero embryonic developmentGO:00017019.7FOXC1, GLI2, SOX18
16kidney developmentGO:00018229.6FOXC1, FOXC2, GLI2
17negative regulation of blood pressureGO:00457769.6DRD5, GCH1
18positive regulation of transcription, DNA-templatedGO:00458939.4FOXC1, FOXC2, GLI2, SOX18
19nitric oxide metabolic processGO:00462099.3GCH1, PTS
20positive regulation of transcription from RNA polymerase II promoterGO:00459449.0FOXC1, FOXC2, GLI2, SOX18

Molecular functions related to Meige Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:00442129.3FOXC1, GLI2, SOX18

Sources for Meige Syndrome

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet