Summaries for Melancholia

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Wikipedia:63 Black bile (Greek: more...

MalaCards based summary: Melancholia is related to endogenous depression and thyroiditis. An important gene associated with Melancholia is AVPR1B (arginine vasopressin receptor 1B), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Cytochrome P450 - arranged by substrate type. The compounds pitressin and acth 1-24 have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and brain, and related mouse phenotypes are growth/size/body and integument.

Aliases & Classifications for Melancholia

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Melancholia, Aliases & Descriptions:

Name: Melancholia 9 11 60


External Ids:

Disease Ontology9 DOID:2848
MeSH33 D003866
SNOMED-CT55 35489007
NCIt38 C34812

Related Diseases for Melancholia

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Diseases related to Melancholia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1endogenous depression30.5TRH, SLC6A4, CRH, MAOA
2thyroiditis30.3POMC, TRH
3addison's disease30.2CRH, POMC
4personality disorder30.1MAOA, SLC6A4
5borderline personality disorder30.1MAOA, SLC6A4
6schizophrenia30.0SLC6A4, PRL
7bipolar disorder29.9SLC6A4, CRH, MAOA
8mood disorder29.9POMC, MAOA, CRH, SLC6A4, TRH
9exophthalmos10.5TRH
10euthyroid sick syndrome10.5TRH
11hyperthyroxinemia10.5TRH
12blindness10.4
13serotonin syndrome10.4MAOA
14adrenal carcinoma10.4POMC
15skin disease10.3POMC
16premature ejaculation10.3SLC6A4
17pervasive developmental disorder10.3SLC6A4
18asperger syndrome10.3SLC6A4
19gonadal disease10.3POMC, CRH
20cushing's syndrome10.2POMC, CRH
21cerebritis10.2
22hypoadrenalism10.2POMC, CRH
23west syndrome10.2POMC, CRH
24hypothalamic disease10.2PRL, CRH
25adrenal adenoma10.2POMC, CRH
26congenital adrenal hyperplasia10.2CRH, POMC
27pituitary carcinoma10.2PRL, POMC
28asthma10.2
29dementia10.2
30diabetes insipidus, neurohypophyseal10.2POMC, PRL
31oligomenorrhea10.2POMC, PRL
32hypothryoidism, congenital, nongoitrous 410.1POMC, PRL
33pituitary hormone deficiency, combined, 210.1POMC, PRL
34substance abuse10.1CRH, SLC6A4
35klinefelter's syndrome10.1PRL, TRH
36major depressive disorder and accelerated response to antidepressant drug treatment10.1SLC6A4, CRH
37antisocial personality disorder10.1MAOA, SLC6A4
38adrenocortical carcinoma10.1CRH, POMC
39precocious puberty10.1POMC, PRL
40vitiligo-associated multiple autoimmune disease susceptibility 110.1MAOA, POMC
41social phobia10.1MAOA, SLC6A4
42primary hyperoxaluria10.1POMC, CRH, TRH
43adrenal cortical adenoma10.1CRH, POMC
44fibromyalgia10.1CRH, SLC6A4
45drug dependence10.1MAOA, SLC6A4
46generalized anxiety disorder10.1MAOA, SLC6A4
47conduct disorder10.1MAOA, SLC6A4
48bulimia nervosa10.1MAOA, SLC6A4
49gilles de la tourette syndrome10.1MAOA, SLC6A4
50pain agnosia10.1POMC, CRH

Graphical network of the top 20 diseases related to Melancholia:



Diseases related to melancholia

Symptoms for Melancholia

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Drugs & Therapeutics for Melancholia

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Drug clinical trials:

Search ClinicalTrials for Melancholia

Search NIH Clinical Center for Melancholia

Genetic Tests for Melancholia

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Anatomical Context for Melancholia

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MalaCards organs/tissues related to Melancholia:

31
Testes, Pituitary, Brain, Eye, Cortex, Heart, Thyroid, Prostate, Prefrontal cortex

Animal Models for Melancholia or affiliated genes

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MGI Mouse Phenotypes related to Melancholia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.7TRH, SLC6A4, CRH, POMC, TNF
2MP:00107717.4TNF, POMC, PRL, CRH, SLC6A4
3MP:00053796.9AVPR1B, TNF, POMC, PRL, CRH, SLC6A4
4MP:00053866.8AVPR1B, TNF, POMC, PRL, MAOA, CRH
5MP:00036316.5TRH, AVPR1B, TNF, POMC, PRL, MAOA
6MP:00053766.4AVPR1B, TNF, POMC, PRL, MAOA, CRH

Publications for Melancholia

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Articles related to Melancholia:

(show top 50)    (show all 340)
idTitleAuthorsYear
1
Melancholia: past and present. (23547641)
2013
2
The interdependence of subtype and severity: contributions of clinical and neuropsychological features to melancholia and non-melancholia in an outpatient sample. (22300644)
2012
3
Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression. (21945535)
2012
4
Electroconvulsive therapy and melancholia: review of the literature and suggestions for further study. (21673591)
2011
5
The incidence and prevalence of admissions for melancholia in two cohorts (1875-1924 and 1995-2005). (21733576)
2011
6
Issues for DSM-5: whither melancholia? The case for its classification as a distinct mood disorder. (20595426)
2010
7
Mother, melancholia, and humor in Erik H. Erikson's earliest writings. (19105029)
2008
8
A mixed state core for melancholia: an exploration in history, art and clinical science. (17280570)
2007
9
Resurrecting melancholia. (17280566)
2007
10
In search of Aristotle: temperament, human nature, melancholia, creativity and eminence. (17499855)
2007
11
As a prelude: bringing melancholia to book. (16878733)
2006
12
Black bile and psychomotor retardation: shades of melancholia in Dante's Inferno. (15370340)
2004
13
Functional but not structural subgenual prefrontal cortex abnormalities in melancholia. (14699431)
2004
14
The prolactin response to fenfluramine in depression: effects of melancholia and baseline cortisol. (12680745)
2003
15
The stress response and the hypothalamic-pituitary-adrenal axis: from molecule to melancholia. (10873181)
2000
16
TCM treatment with the modified wendan tang in 40 cases of melancholia. (10921137)
1999
17
Once vs. three times weekly ECT in melancholia: a randomized controlled trial. (9821454)
1998
18
Functional neuroimaging studies of depression: the anatomy of melancholia. (9509268)
1998
19
Variability in the serotonin transporter gene and increased risk for major depression with melancholia. (9799087)
1998
20
Sub-typing depression, III. Development of a clinical algorithm for melancholia and comparison with other diagnostic measures. (7480461)
1995
21
Music and melancholia. (7853306)
1994
22
A double-blind comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia. The Venlafaxine French Inpatient Study Group. (7814822)
1994
23
A modern melancholia: Van Gogh's portrait of Dr Gachet. (8234566)
1993
24
The anatomy of melancholia--focal abnormalities of cerebral blood flow in major depression. (1410086)
1992
25
Time experience in melancholia: a comparison between findings based on phenomenology and experimental psychology. (1935022)
1991
26
Time estimation and the experience of time in endogenous depression (Melancholia): an experimental investigation. (2023986)
1991
27
Prediction of ECT Response in Melancholia. (11941106)
1991
28
Factor study of the Hamilton Rating Scale for Depression and the Bech Melancholia Scale. (2239363)
1990
29
Corticotropin, cortisol and beta-endorphin responses to the human corticotropin-releasing hormone during melancholia and after unilateral electroconvulsive therapy. (2174200)
1990
30
Results of the 8 a.m. dexamethasone suppression test constitute a suitable tool for confirming the diagnosis of melancholia. A test unaffected by the variations in the bioavailability of dexamethasone. (2639285)
1989
31
The current age of youthful melancholia. Evidence for increase in depression among adolescents and young adults. (3167377)
1988
32
Relationships of the dexamethasone suppression test to clinical severity and degree of melancholia. (3697434)
1986
33
Hypochondriacal fears and beliefs in DSM-III melancholia. Changes with amitriptyline. (2939120)
1986
34
DSM-III melancholia: do the criteria accurately and reliably distinguish endogenous pattern depression? (2943772)
1986
35
Ruminative thinking. A distinctive sign of melancholia. (3160746)
1985
36
The tyramine challenge test as a marker for melancholia. (6732426)
1984
37
Attribution style, the dexamethasone suppression test, and the diagnosis of melancholia in depressed inpatients. (6512083)
1984
38
Comparative diagnostic criteria for melancholia and endogenous depression. (6721673)
1984
39
Dexamethasone suppression tests in antidepressant treatment of melancholia. The process of normalization and test-retest reproducibility. (6340634)
1983
40
The "myth' of involutional melancholia. (7043302)
1982
41
Fluctuating postdexamethasone cortisol levels in a patient with melancholia. (7055259)
1982
42
Depression: a multivariate study of Sir Aubrey Lewis's data on melancholia. (336020)
1977
43
Mental hospital admissions in England and Wales 1950-60 for all diagnoses, manic depressive reaction and involutional melancholia. (6072175)
1967
44
Melancholia: diagnostic hints. (13863481)
1962
45
Investigations on the aetiology of involutional melancholia. (14430414)
1959
46
Involutional melancholia and depressive states: results of treatment over a 5-year period. (14888627)
1951
47
Involutional melancholia and convulsive therapy. (18135401)
1949
48
Personality adjustment following hospital treatment in patients with involutional psychosis, melancholia. (18911132)
1948
49
The prognosis and treatment of melancholia. (20287236)
1947
50
A Case of Melancholia, Associated with, and Perhaps Due to, Addison's Disease. (20744702)
1867

Variations for Melancholia

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Expression for genes affiliated with Melancholia

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Search GEO for disease gene expression data for Melancholia.

Pathways for genes affiliated with Melancholia

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Pathways related to Melancholia according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CRH, POMC
2
Show member pathways
9.6MAOA, POMC
39.5PRL, POMC
4
Show member pathways
9.5POMC, TRH
59.4MAOA, SLC6A4
69.2POMC, TNF
78.6TNF, MAOA, SLC6A4
8
Show member pathways
Serotonin Transporter Activity36
8.6SLC6A4, MAOA, TNF
9
Show member pathways
8.3CRH, MAOA, PRL, TNF
10
Show member pathways
8.3TRH, CRH, PRL, POMC, AVPR1B
11
Show member pathways
8.3AVPR1B, POMC, PRL, CRH, TRH

Compounds for genes affiliated with Melancholia

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Compounds related to Melancholia according to GeneCards Suite gene sharing:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1pitressin439.6POMC, CRH
2acth 1-24439.5CRH, PRL, POMC
311 deoxycortisol439.5PRL, CRH, POMC
4hexarelin43 2810.5POMC, PRL, CRH
5desmopressin43 59 28 1212.4CRH, POMC, AVPR1B
6alprazolam43 1210.4CRH, MAOA, POMC
7naltrexone43 28 49 1212.4POMC, PRL, CRH
8pyridostigmine43 1210.4TRH, CRH, PRL
9sulpiride43 28 1211.4TRH, CRH, PRL
10hcrh439.3CRH, POMC
1117-hydroxyprogesterone43 2410.3PRL, POMC, CRH
125-hydroxyindoleacetic acid43 2410.3SLC6A4, CRH, MAOA
135-hydroxytryptophan439.3CRH, PRL, SLC6A4
14mdma439.3PRL, MAOA, SLC6A4
15maoa439.3SLC6A4, MAOA, POMC
16dehydroepiandrosterone sulfate439.2PRL, POMC, CRH
17diazepam43 28 49 1212.1TRH, CRH, POMC
18paroxetine43 49 28 1212.1SLC6A4, MAOA, PRL
19bromocriptine43 28 1211.1PRL, TRH, POMC
20sertraline43 28 49 24 1213.1SLC6A4, CRH, MAOA, POMC
21naloxone43 28 49 1212.0CRH, TRH, POMC, PRL
22mhpg439.0CRH, MAOA, SLC6A4, PRL
23homovanillic acid43 2410.0CRH, MAOA, PRL, SLC6A4
24clomipramine43 49 1211.0SLC6A4, PRL, MAOA, CRH
25octreotide43 59 28 1212.0CRH, POMC, PRL, TRH
26desipramine43 49 1211.0CRH, TRH, SLC6A4, MAOA
27fluoxetine43 49 28 1212.0SLC6A4, CRH, MAOA, PRL
28citalopram43 49 24 1211.9CRH, PRL, SLC6A4, MAOA
29mirtazapine43 49 1210.9SLC6A4, CRH, PRL, POMC
30amphetamine43 49 1210.9SLC6A4, MAOA, POMC
31opiate438.9PRL, SLC6A4, POMC, CRH
32thyroxine43 249.8TRH, CRH, POMC, PRL
33clonidine43 49 28 1211.7TRH, POMC, PRL, SLC6A4
34haloperidol43 49 28 2 1212.7TRH, POMC, PRL, SLC6A4
35carbamazepine43 49 1210.7POMC, PRL, CRH, TNF
36acth438.7POMC, TRH, CRH, PRL, AVPR1B
37corticosterone43 59 2410.6SLC6A4, CRH, PRL, POMC, AVPR1B
385-hydroxytryptamine438.5POMC, MAOA, PRL, CRH, SLC6A4
39gaba438.5POMC, MAOA, CRH, SLC6A4, TRH
40epinephrine43 24 1210.5PRL, MAOA, SLC6A4, CRH, POMC
41fenfluramine43 28 1210.4TRH, CRH, POMC, PRL, SLC6A4
42cocaine43 129.4PRL, CRH, SLC6A4, TRH, POMC
43gnrh438.4POMC, PRL, CRH, SLC6A4, TRH
44hydrocortisone43 2 59 1211.2TNF, TRH, CRH, PRL, POMC
45norepinephrine43 24 1210.0TRH, MAOA, SLC6A4, POMC, CRH, PRL
46dopamine43 28 24 1211.0POMC, TRH, SLC6A4, CRH, MAOA, PRL
47arginine438.0AVPR1B, PRL, CRH, SLC6A4, TRH, POMC
48testosterone43 59 24 1211.0SLC6A4, POMC, PRL, TRH, CRH, MAOA
49estrogen437.9TRH, POMC, SLC6A4, CRH, MAOA, PRL
50dexamethasone43 49 28 1210.7TNF, POMC, PRL, MAOA, CRH, TRH

GO Terms for genes affiliated with Melancholia

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Cellular components related to Melancholia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.5TRH, POMC
2extracellular regionGO:00055768.8TRH, CRH, POMC

Biological processes related to Melancholia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to corticosteroneGO:00514129.6TRH, CRH
2response to ethanolGO:00454719.6TRH, CRH
3female pregnancyGO:00075659.3CRH, PRL
4negative regulation of gene expressionGO:00106299.2CRH, TNF
5response to drugGO:00424938.7TNF, CRH, SLC6A4
6response to hypoxiaGO:00016668.6TRH, SLC6A4, TNF

Molecular functions related to Melancholia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.6TRH, CRH
2hormone activityGO:00051798.8CRH, PRL, POMC

Products for genes affiliated with Melancholia

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Sources for Melancholia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet