MCID: MLN003
MIFTS: 46

Melancholia malady

Summaries for Melancholia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Melancholia (from Greek μελαγχολία melancholia \"sadness\", literally black bile), also... more...

MalaCards: Melancholia is related to endogenous depression and mood disorder. An important gene associated with Melancholia is AVPR1B (arginine vasopressin receptor 1B), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Development Leptin signaling via JAK/STAT and MAPK cascades. The compounds gnrh and hcrh have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and eye, and related mouse phenotypes are integument and endocrine/exocrine gland.

Aliases & Classifications for Melancholia

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

melancholia 8 10 60


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Disease Ontology8 DOID:2848
NCIt39 C34812
SNOMED-CT56 35489007
MeSH34 D003866

Related Diseases for Melancholia

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17GeneCards, 18GeneDecks
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Diseases related to Melancholia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1endogenous depression30.7CRH, SLC6A4
2mood disorder30.4CRH, TRH, POMC, MAOA, SLC6A4
3bipolar disorder30.2CRH, MAOA, SLC6A4
4addison's disease29.9POMC, CRH
5seasonal affective disorder29.9SLC6A4, CRH
6thyroiditis29.9TRH, POMC
7borderline personality disorder29.9SLC6A4, MAOA
8personality disorder29.9MAOA, SLC6A4
9dementia29.9TRH, MAOA, PLP1
10multiple sclerosis29.9TNF, POMC, PLP1
11schizophrenia29.8PRL, TRH, MAOA, PLP1, SLC6A4
12major depressive disorder10.3
13cerebritis10.2
14asthma10.1
15mental depression10.1
16parkinson's disease10.0MAOA
17cerebrovascular disease10.0TRH
18hyperthyroxinemia10.0TRH
19euthyroid sick syndrome10.0TRH
20exophthalmos10.0TRH
21leukodystrophy10.0PLP1
22cerebral palsy10.0PLP1
23prion disease10.0POMC
24serotonin syndrome10.0MAOA
25myasthenia gravis10.0PLP1
26adrenal carcinoma10.0POMC
27psoriatic arthritis10.0TNF
28myocardial infarction10.0SLC6A4
29acute myocardial infarction10.0SLC6A4
30ulcerative colitis10.0TNF
31sudden infant death syndrome10.0SLC6A4
32premature ejaculation10.0SLC6A4
33carney complex10.0POMC
34anovulation10.0PRL
35infertility10.0PRL
36pheochromocytoma10.0POMC, CRH
37adrenal adenoma10.0POMC, CRH
38substance dependence10.0SLC6A4
39fibromyalgia10.0SLC6A4, CRH
40substance abuse10.0SLC6A4, CRH
41hypokalemia10.0POMC
42gonadal disease10.0CRH, POMC
43cushing's syndrome10.0CRH, POMC
44irritable bowel syndrome10.0CRH, SLC6A4
45infantile epileptic encephalopathy10.0CRH, POMC
46bulimia nervosa10.0SLC6A4, MAOA
47obsessive-compulsive disorder10.0SLC6A4, MAOA
48hypoadrenalism10.0CRH, POMC
49severe pre-eclampsia10.0MAOA
50encephalomyelitis10.0PLP1, TNF

Graphical network of the top 20 diseases related to Melancholia:



Diseases related to melancholia

Clinical Features for Melancholia

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Drugs & Therapeutics for Melancholia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Melancholia

Drug clinical trials:

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Search NIH Clinical Center for Melancholia

Search CenterWatch for Melancholia

Genetic Tests for Melancholia

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Anatomical Context for Melancholia

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32MalaCards
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MalaCards organs/tissues related to Melancholia:

32
Testes, Pituitary, Eye, Brain, Cortex, Thyroid, Prostate, Prefrontal cortex

Animal Models for Melancholia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Melancholia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.7SLC6A4, POMC, PRL, CRH, TNF
2MP:00053796.6TNF, CRH, PRL, TRH, POMC, AVPR1B
3MP:00053866.5TNF, CRH, PRL, POMC, MAOA, AVPR1B
4MP:00036316.1SLC6A4, TNF, CRH, PRL, TRH, POMC
5MP:00053766.1TNF, CRH, PRL, TRH, POMC, MAOA

Publications for Melancholia

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50PubMed
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Articles related to Melancholia:

(show top 50)    (show all 328)
idTitleAuthorsYear
1
Validation of a new prototypic measure of melancholia. (23602392)
2013
2
Melancholia: a distinct entity? (23547639)
2013
3
Should psychomotor disturbance be an essential criterion for a DSM-5 diagnosis of melancholia? (23724792)
2013
4
The interdependence of subtype and severity: contributions of clinical and neuropsychological features to melancholia and non-melancholia in an outpatient sample. (22300644)
2012
5
Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression. (21945535)
2012
6
Melancholia. (22156933)
2012
7
Electroconvulsive therapy and melancholia: review of the literature and suggestions for further study. (21673591)
2011
8
The incidence and prevalence of admissions for melancholia in two cohorts (1875-1924 and 1995-2005). (21733576)
2011
9
Melancholia in Latin American studies: a distinct mood disorder for the ICD-11. (21845334)
2011
10
Venlafaxine plus mirtazapine as first-line treatment for melancholia: preliminary results. (21138931)
2010
11
Melancholia as a useful subtype of major depression. (19818258)
2009
12
Naming the nonexistent: melancholia as mourning over a possible object. (18315463)
2008
13
Atypical depression: current status and relevance to melancholia. (17280572)
2007
14
Defining melancholia: the primacy of psychomotor disturbance. (17280567)
2007
15
Melancholia: restoration in psychiatric classification recommended. (17244171)
2007
16
As a prelude: bringing melancholia to book. (16878733)
2006
17
Mania, dementia and melancholia in the 1870s: admissions to a Cornwall asylum. (12835458)
2003
18
The Bech-Rafaelsen Melancholia Scale (MES) in clinical trials of therapies in depressive disorders: a 20-year review of its use as outcome measure. (12225492)
2002
19
Dimensionality of depression in acute schizophrenia: a methodological study using the Bech-Rafaelsen Melancholia Scale (BRMES). (9844953)
1998
20
Utilising molecular biological and histopathological techniques to study the dopaminergic system in patients with melancholia. (9088483)
1997
21
Bilateral ECT and autobiographical memory of subjective experiences related to melancholia: a pilot study. (8938200)
1996
22
Music and melancholia. (7636831)
1995
23
Defining melancholia: properties of a refined sign-based measure. (8199785)
1994
24
Diurnal variation of mood and neuropsychological function in major depression with melancholia. (7897090)
1994
25
Prediction of response to antidepressant medication by a sign-based index of melancholia. (8481171)
1993
26
The anatomy of melancholia--focal abnormalities of cerebral blood flow in major depression. (1410086)
1992
27
Time experience in melancholia: a comparison between findings based on phenomenology and experimental psychology. (1935022)
1991
28
Platelet alpha-2 adrenoreceptor activity pre-treatment and post-treatment in major depressive disorder with melancholia. (1666199)
1991
29
Distinguishing psychotic and non-psychotic melancholia. (1918657)
1991
30
Abnormal pituitary function during melancholia: reduced alpha-melanocyte-stimulating hormone secretion and increased intact ACTH non-suppression. (1655852)
1991
31
Melancholia and MRI. (1675713)
1991
32
Corticotropin, cortisol and beta-endorphin responses to the human corticotropin-releasing hormone during melancholia and after unilateral electroconvulsive therapy. (2174200)
1990
33
Does melancholia predict response in major depression? (2139060)
1990
34
Abnormal visual evoked response in melancholia. (2923938)
1989
35
The Diagnostic Melancholia Scale (DMS): dimensions of endogenous and reactive depression with relationship to the Newcastle Scales. (2966830)
1988
36
Effect of ECT on Cerebral Blood Flow in Melancholia Assessed with SPECT. (11940943)
1988
37
Nocturnal prolactin and cortisol secretion and recovery from melancholia. (3659229)
1987
38
Compatibility between ICD-9 and DSM-III classification of endogenous depression (melancholia). (3703924)
1986
39
Specificity of the combined dexamethasone suppression and TRH/TSH tests in melancholia. (3937177)
1985
40
Cerebrospinal fluid monoamine and monoamine metabolite concentrations in melancholia. (2415996)
1985
41
Biological correlations of suicide and aggressivity in major depressions (with melancholia): 5-hydroxyindoleacetic acid and cortisol in cerebral spinal fluid, dexamethasone suppression test and therapeutic response to 5-hydroxytryptophan. (2418384)
1985
42
Involutional melancholia revisited. (6691457)
1984
43
Failure to mourn, and melancholia. (7171907)
1982
44
Dexamethasone suppression test and diagnosis of melancholia. (7125852)
1982
45
Mental hospital admissions in England and Wales 1950-60 for all diagnoses, manic depressive reaction and involutional melancholia. (6072175)
1967
46
Involutional melancholia: an etiologic, clinical and social study of endogenous depression in later life, with special reference to genetic factors. (13626607)
1959
47
Involutional melancholia as a disease of adaptation. (13481105)
1957
48
Pruritus in melancholia. (13209169)
1954
49
Anxiety after electroshock therapy in involutional melancholia. (13093924)
1953
50
Climate or Environment as a Factor in the Repair of Neurasthenia and Melancholia. (21409145)
1897

Genetic Variations for Melancholia

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Expression for genes affiliated with Melancholia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Melancholia

Search GEO for disease gene expression data for Melancholia.

Pathways for genes affiliated with Melancholia

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49PharmGKB, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 53Reactome
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Pathways related to Melancholia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CRH, POMC
2
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.5POMC, TRH
39.1SLC6A4, TNF
4
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8.9MAOA, CRH, TNF
58.3SLC6A4, PLP1, MAOA, TNF
6
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8.2CRH, PRL, TRH, POMC, AVPR1B

Compounds for genes affiliated with Melancholia

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Melancholia according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1gnrh4410.3TRH
2hcrh449.8CRH, POMC
3pitressin449.7POMC, CRH
45-hydroxyindoleacetic acid44 2410.5MAOA, CRH, SLC6A4
5desmopressin44 59 28 1112.5AVPR1B, CRH, POMC
6alprazolam44 1110.5POMC, MAOA, CRH
7acth 1-24449.4PRL, CRH, POMC
8maoa449.4MAOA, POMC, SLC6A4
911 deoxycortisol449.4PRL, POMC, CRH
10hexarelin44 2810.4PRL, CRH, POMC
11citalopram49 44 11 2412.4PRL, MAOA, SLC6A4
12naltrexone44 49 28 1112.3POMC, PRL, CRH
13pyridostigmine44 1110.3PRL, TRH, CRH
14mdma449.3SLC6A4, PRL, MAOA
155-hydroxytryptophan449.3SLC6A4, PRL, CRH
16sulpiride44 28 1111.3TRH, PRL, CRH
1717-hydroxyprogesterone44 2410.3CRH, PRL, POMC
18sertraline44 28 49 11 2413.2POMC, CRH, SLC6A4, MAOA
19paroxetine44 49 28 1112.1MAOA, PRL, SLC6A4
20desipramine44 49 1111.1SLC6A4, MAOA, TRH, CRH
21mhpg449.1MAOA, CRH, PRL, SLC6A4
22dehydroepiandrosterone sulfate449.1CRH, POMC, PRL
23homovanillic acid44 2410.1SLC6A4, MAOA, PRL, CRH
24diazepam44 49 28 1112.1CRH, TRH, POMC
25clomipramine44 49 1111.0SLC6A4, MAOA, PRL, CRH
26fluoxetine49 44 28 1112.0PRL, MAOA, CRH, SLC6A4
27mirtazapine49 44 1111.0PRL, POMC, SLC6A4, CRH
28bromocriptine28 44 1110.9PRL, POMC, TRH
29naloxone44 49 28 1111.9PRL, POMC, CRH, TRH
30octreotide44 59 28 1111.9CRH, POMC, TRH, PRL
31opiate448.9PRL, SLC6A4, CRH, POMC
32amphetamine44 119.8POMC, MAOA, SLC6A4
33thyroxine44 249.8PRL, POMC, CRH, TRH
34clonidine44 28 1110.7PRL, TRH, POMC, SLC6A4
35haloperidol44 28 2 49 1112.7SLC6A4, POMC, TRH, PRL
36corticosterone44 59 2410.6CRH, SLC6A4, AVPR1B, POMC, PRL
37carbamazepine44 49 1110.6CRH, PRL, POMC, TNF
38acth448.6POMC, TRH, PRL, CRH, AVPR1B
395-hydroxytryptamine448.6POMC, PRL, CRH, MAOA, SLC6A4
40epinephrine44 11 2410.5PRL, POMC, MAOA, CRH, SLC6A4
41fenfluramine28 44 1110.5CRH, PRL, TRH, POMC, SLC6A4
42gaba448.3TRH, SLC6A4, PLP1, CRH, MAOA, POMC
43hydrocortisone44 2 59 1111.1POMC, CRH, PRL, TRH, TNF
44norepinephrine44 11 2410.1SLC6A4, MAOA, POMC, PRL, TRH, CRH
45dopamine44 28 11 2411.1TRH, CRH, PRL, SLC6A4, POMC, MAOA
46cocaine44 119.0TRH, POMC, PRL, CRH, SLC6A4, PLP1
47testosterone44 59 11 2411.0SLC6A4, CRH, PRL, TRH, POMC, MAOA
48estrogen447.9CRH, MAOA, PRL, TRH, POMC, SLC6A4
49arginine447.7PRL, SLC6A4, TRH, POMC, AVPR1B, PLP1
50dexamethasone44 49 28 1110.7POMC, CRH, TRH, TNF, MAOA, PRL

GO Terms for genes affiliated with Melancholia

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16Gene Ontology
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Cellular components related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.6POMC, TRH, PRL
2extracellular regionGO:0055767.7POMC, TRH, PRL, CRH, TNF

Biological processes related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to corticosterone stimulusGO:0514129.6TRH, CRH
2parturitionGO:0075679.5CRH, PRL
3positive regulation of gene expressionGO:0106289.1SLC6A4, PLP1, CRH
4response to ethanolGO:0454719.1TRH, PRL, CRH
5response to hypoxiaGO:0016668.3SLC6A4, TRH, TNF
6response to drugGO:0424938.3SLC6A4, PRL, CRH, TNF

Molecular functions related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6TRH, CRH
2hormone activityGO:0051798.8POMC, PRL, CRH

Products for genes affiliated with Melancholia

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Sources for Melancholia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet