MCID: MLN003
MIFTS: 49

Melancholia malady

Mental diseases category
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Summaries for Melancholia

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Wikipedia:65 Melancholia (from Greek ?????????? melancholia \"sadness\", literally black bile), also lugubriousness,... more...

MalaCards based summary: Melancholia is related to endogenous depression and thyroiditis. An important gene associated with Melancholia is AVPR1B (arginine vasopressin receptor 1B), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Cytochrome P450 - arranged by substrate type. The compounds pitressin and acth 1-24 have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and brain, and related mouse phenotypes are growth/size/body and integument.

Aliases & Classifications for Melancholia

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Melancholia, Aliases & Descriptions:

Name: Melancholia 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:2848
MeSH34 D003866
SNOMED-CT57 35489007
NCIt39 C34812

Related Diseases for Melancholia

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Diseases related to Melancholia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1endogenous depression31.0SLC6A4, CRH
2thyroiditis30.3POMC, TRH
3addison's disease30.2CRH, POMC
4seasonal affective disorder30.2SLC6A4, CRH
5personality disorder30.1MAOA, SLC6A4
6borderline personality disorder30.1MAOA, SLC6A4
7bipolar disorder29.9SLC6A4, CRH, MAOA
8mood disorder29.9POMC, MAOA, CRH, SLC6A4, TRH
9schizophrenia29.5PRL, MAOA, SLC6A4, TRH
10exophthalmos10.5TRH
11euthyroid sick syndrome10.5TRH
12hyperthyroxinemia10.5TRH
13serotonin syndrome10.4MAOA
14blindness10.4
15adrenal carcinoma10.4POMC
16major depressive disorder10.3
17skin disease10.3POMC
18premature ejaculation10.3SLC6A4
19pervasive developmental disorder10.3SLC6A4
20asperger syndrome10.3SLC6A4
21gonadal disease10.3POMC, CRH
22cushing's syndrome10.3POMC, CRH
23hypoadrenalism10.3POMC, CRH
24infantile epileptic encephalopathy10.2POMC, CRH
25cerebritis10.2
26hypothalamic disease10.2PRL, CRH
27adrenal adenoma10.2POMC, CRH
28congenital adrenal hyperplasia10.2CRH, POMC
29pituitary carcinoma10.2PRL, POMC
30neurogenic diabetes insipidus10.2POMC, PRL
31thyrotropin deficiency, isolated10.2POMC, PRL
32asthma10.1
33dementia10.1
34panhypopituitarism10.1POMC, PRL
35substance abuse10.1CRH, SLC6A4
36klinefelter's syndrome10.1PRL, TRH
37adrenocortical carcinoma10.1CRH, POMC
38antisocial personality disorder10.1MAOA, SLC6A4
39vitiligo10.1MAOA, POMC
40precocious puberty10.1POMC, PRL
41adrenal cortical adenoma10.1CRH, POMC
42social phobia10.1MAOA, SLC6A4
43primary hyperoxaluria10.1POMC, CRH, TRH
44fibromyalgia10.1CRH, SLC6A4
45pain agnosia10.1POMC, CRH
46drug dependence10.1MAOA, SLC6A4
47generalized anxiety disorder10.1MAOA, SLC6A4
48conduct disorder10.1MAOA, SLC6A4
49bulimia nervosa10.1MAOA, SLC6A4
50gilles de la tourette syndrome10.1MAOA, SLC6A4

Graphical network of the top 20 diseases related to Melancholia:



Diseases related to melancholia

Symptoms for Melancholia

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Drugs & Therapeutics for Melancholia

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Drug clinical trials:

Search ClinicalTrials for Melancholia

Search NIH Clinical Center for Melancholia

Genetic Tests for Melancholia

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Anatomical Context for Melancholia

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MalaCards organs/tissues related to Melancholia:

32
Testes, Pituitary, Brain, Eye, Cortex, Thyroid, Prostate, Prefrontal cortex

Animal Models for Melancholia or affiliated genes

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MGI Mouse Phenotypes related to Melancholia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.7TRH, SLC6A4, CRH, POMC, TNF
2MP:00107717.4TNF, POMC, PRL, CRH, SLC6A4
3MP:00053796.9AVPR1B, TNF, POMC, PRL, CRH, SLC6A4
4MP:00053866.8AVPR1B, TNF, POMC, PRL, MAOA, CRH
5MP:00036316.5TRH, AVPR1B, TNF, POMC, PRL, MAOA
6MP:00053766.4AVPR1B, TNF, POMC, PRL, MAOA, CRH

Publications for Melancholia

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Articles related to Melancholia:

(show top 50)    (show all 333)
idTitleAuthorsYear
1
Melancholia: past and present. (23547641)
2013
2
The interdependence of subtype and severity: contributions of clinical and neuropsychological features to melancholia and non-melancholia in an outpatient sample. (22300644)
2012
3
Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression. (21945535)
2012
4
Electroconvulsive therapy and melancholia: review of the literature and suggestions for further study. (21673591)
2011
5
The incidence and prevalence of admissions for melancholia in two cohorts (1875-1924 and 1995-2005). (21733576)
2011
6
Issues for DSM-5: whither melancholia? The case for its classification as a distinct mood disorder. (20595426)
2010
7
Mother, melancholia, and humor in Erik H. Erikson's earliest writings. (19105029)
2008
8
A mixed state core for melancholia: an exploration in history, art and clinical science. (17280570)
2007
9
Resurrecting melancholia. (17280566)
2007
10
In search of Aristotle: temperament, human nature, melancholia, creativity and eminence. (17499855)
2007
11
As a prelude: bringing melancholia to book. (16878733)
2006
12
Black bile and psychomotor retardation: shades of melancholia in Dante's Inferno. (15370340)
2004
13
Functional but not structural subgenual prefrontal cortex abnormalities in melancholia. (14699431)
2004
14
The prolactin response to fenfluramine in depression: effects of melancholia and baseline cortisol. (12680745)
2003
15
The stress response and the hypothalamic-pituitary-adrenal axis: from molecule to melancholia. (10873181)
2000
16
TCM treatment with the modified wendan tang in 40 cases of melancholia. (10921137)
1999
17
Once vs. three times weekly ECT in melancholia: a randomized controlled trial. (9821454)
1998
18
Functional neuroimaging studies of depression: the anatomy of melancholia. (9509268)
1998
19
Variability in the serotonin transporter gene and increased risk for major depression with melancholia. (9799087)
1998
20
Sub-typing depression, III. Development of a clinical algorithm for melancholia and comparison with other diagnostic measures. (7480461)
1995
21
Music and melancholia. (7853306)
1994
22
A double-blind comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia. The Venlafaxine French Inpatient Study Group. (7814822)
1994
23
A modern melancholia: Van Gogh's portrait of Dr Gachet. (8234566)
1993
24
The anatomy of melancholia--focal abnormalities of cerebral blood flow in major depression. (1410086)
1992
25
Time experience in melancholia: a comparison between findings based on phenomenology and experimental psychology. (1935022)
1991
26
Time estimation and the experience of time in endogenous depression (Melancholia): an experimental investigation. (2023986)
1991
27
Prediction of ECT Response in Melancholia. (11941106)
1991
28
Factor study of the Hamilton Rating Scale for Depression and the Bech Melancholia Scale. (2239363)
1990
29
Corticotropin, cortisol and beta-endorphin responses to the human corticotropin-releasing hormone during melancholia and after unilateral electroconvulsive therapy. (2174200)
1990
30
Results of the 8 a.m. dexamethasone suppression test constitute a suitable tool for confirming the diagnosis of melancholia. A test unaffected by the variations in the bioavailability of dexamethasone. (2639285)
1989
31
The current age of youthful melancholia. Evidence for increase in depression among adolescents and young adults. (3167377)
1988
32
Relationships of the dexamethasone suppression test to clinical severity and degree of melancholia. (3697434)
1986
33
Hypochondriacal fears and beliefs in DSM-III melancholia. Changes with amitriptyline. (2939120)
1986
34
DSM-III melancholia: do the criteria accurately and reliably distinguish endogenous pattern depression? (2943772)
1986
35
Ruminative thinking. A distinctive sign of melancholia. (3160746)
1985
36
The tyramine challenge test as a marker for melancholia. (6732426)
1984
37
Attribution style, the dexamethasone suppression test, and the diagnosis of melancholia in depressed inpatients. (6512083)
1984
38
Comparative diagnostic criteria for melancholia and endogenous depression. (6721673)
1984
39
Dexamethasone suppression tests in antidepressant treatment of melancholia. The process of normalization and test-retest reproducibility. (6340634)
1983
40
The "myth' of involutional melancholia. (7043302)
1982
41
Fluctuating postdexamethasone cortisol levels in a patient with melancholia. (7055259)
1982
42
Depression: a multivariate study of Sir Aubrey Lewis's data on melancholia. (336020)
1977
43
Mental hospital admissions in England and Wales 1950-60 for all diagnoses, manic depressive reaction and involutional melancholia. (6072175)
1967
44
Melancholia: diagnostic hints. (13863481)
1962
45
Investigations on the aetiology of involutional melancholia. (14430414)
1959
46
Involutional melancholia and depressive states: results of treatment over a 5-year period. (14888627)
1951
47
Involutional melancholia and convulsive therapy. (18135401)
1949
48
Personality adjustment following hospital treatment in patients with involutional psychosis, melancholia. (18911132)
1948
49
The prognosis and treatment of melancholia. (20287236)
1947
50
A Case of Melancholia, Associated with, and Perhaps Due to, Addison's Disease. (20744702)
1867

Variations for Melancholia

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Expression for genes affiliated with Melancholia

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Expression patterns in normal tissues for genes affiliated with Melancholia

Search GEO for disease gene expression data for Melancholia.

Pathways for genes affiliated with Melancholia

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Pathways related to Melancholia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CRH, POMC
2
Show member pathways
9.6MAOA, POMC
39.5PRL, POMC
4
Show member pathways
9.5POMC, TRH
59.4MAOA, SLC6A4
69.2POMC, TNF
78.6TNF, MAOA, SLC6A4
8
Show member pathways
Serotonin Transporter Activity37
8.6SLC6A4, MAOA, TNF
9
Show member pathways
8.3CRH, MAOA, PRL, TNF
10
Show member pathways
8.3TRH, CRH, PRL, POMC, AVPR1B
11
Show member pathways
8.3AVPR1B, POMC, PRL, CRH, TRH

Compounds for genes affiliated with Melancholia

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Compounds related to Melancholia according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1pitressin449.6POMC, CRH
2acth 1-24449.5CRH, PRL, POMC
311 deoxycortisol449.5PRL, CRH, POMC
4hexarelin44 2810.5POMC, PRL, CRH
5desmopressin44 61 28 1112.4CRH, POMC, AVPR1B
6alprazolam44 1110.4CRH, MAOA, POMC
7naltrexone44 28 50 1112.4POMC, PRL, CRH
8pyridostigmine44 1110.4TRH, CRH, PRL
9sulpiride44 28 1111.4TRH, CRH, PRL
10hcrh449.3CRH, POMC
1117-hydroxyprogesterone44 2410.3PRL, POMC, CRH
125-hydroxyindoleacetic acid44 2410.3SLC6A4, CRH, MAOA
135-hydroxytryptophan449.3CRH, PRL, SLC6A4
14mdma449.3PRL, MAOA, SLC6A4
15maoa449.3SLC6A4, MAOA, POMC
16dehydroepiandrosterone sulfate449.2PRL, POMC, CRH
17diazepam44 28 50 1112.1TRH, CRH, POMC
18paroxetine44 50 28 1112.1SLC6A4, MAOA, PRL
19bromocriptine44 28 1111.1PRL, TRH, POMC
20sertraline44 28 50 24 1113.1SLC6A4, CRH, MAOA, POMC
21naloxone44 28 50 1112.0CRH, TRH, POMC, PRL
22mhpg449.0CRH, MAOA, SLC6A4, PRL
23homovanillic acid44 2410.0CRH, MAOA, PRL, SLC6A4
24clomipramine44 50 1111.0SLC6A4, PRL, MAOA, CRH
25octreotide44 61 28 1112.0CRH, POMC, PRL, TRH
26desipramine44 50 1111.0CRH, TRH, SLC6A4, MAOA
27fluoxetine44 50 28 1112.0SLC6A4, CRH, MAOA, PRL
28citalopram44 50 24 1111.9CRH, PRL, SLC6A4, MAOA
29mirtazapine44 50 1110.9SLC6A4, CRH, PRL, POMC
30amphetamine44 50 1110.9SLC6A4, MAOA, POMC
31opiate448.9PRL, SLC6A4, POMC, CRH
32thyroxine44 249.8TRH, CRH, POMC, PRL
33clonidine44 50 28 1111.7TRH, POMC, PRL, SLC6A4
34haloperidol44 50 28 2 1112.7TRH, POMC, PRL, SLC6A4
35carbamazepine44 50 1110.7POMC, PRL, CRH, TNF
36acth448.7POMC, TRH, CRH, PRL, AVPR1B
37corticosterone44 61 2410.6SLC6A4, CRH, PRL, POMC, AVPR1B
385-hydroxytryptamine448.5POMC, MAOA, PRL, CRH, SLC6A4
39gaba448.5POMC, MAOA, CRH, SLC6A4, TRH
40epinephrine44 24 1110.5PRL, MAOA, SLC6A4, CRH, POMC
41fenfluramine44 28 1110.4TRH, CRH, POMC, PRL, SLC6A4
42cocaine44 119.4PRL, CRH, SLC6A4, TRH, POMC
43gnrh448.4POMC, PRL, CRH, SLC6A4, TRH
44hydrocortisone44 2 61 1111.2TNF, TRH, CRH, PRL, POMC
45norepinephrine44 24 1110.0TRH, MAOA, SLC6A4, POMC, CRH, PRL
46dopamine44 28 24 1111.0POMC, TRH, SLC6A4, CRH, MAOA, PRL
47arginine448.0AVPR1B, PRL, CRH, SLC6A4, TRH, POMC
48testosterone44 61 24 1111.0SLC6A4, POMC, PRL, TRH, CRH, MAOA
49estrogen447.9TRH, POMC, SLC6A4, CRH, MAOA, PRL
50dexamethasone44 50 28 1110.7TNF, POMC, PRL, MAOA, CRH, TRH

GO Terms for genes affiliated with Melancholia

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Cellular components related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.5TRH, POMC
2extracellular regionGO:0055768.8TRH, CRH, POMC

Biological processes related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to corticosteroneGO:0514129.6TRH, CRH
2response to ethanolGO:0454719.6TRH, CRH
3female pregnancyGO:0075659.3CRH, PRL
4negative regulation of gene expressionGO:0106299.2CRH, TNF
5response to drugGO:0424938.7TNF, CRH, SLC6A4
6response to hypoxiaGO:0016668.6TRH, SLC6A4, TNF

Molecular functions related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6TRH, CRH
2hormone activityGO:0051798.8CRH, PRL, POMC

Products for genes affiliated with Melancholia

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Sources for Melancholia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet