MCID: MLN003
MIFTS: 34

Melancholia malady

Categories: Mental diseases

Aliases & Classifications for Melancholia

Aliases & Descriptions for Melancholia:

Name: Melancholia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2848
MeSH 42 D003866
NCIt 47 C34812
SNOMED-CT 64 35489007
UMLS 69 C0025193

Summaries for Melancholia

MalaCards based summary : Melancholia is related to endogenous depression and intermittent squint. An important gene associated with Melancholia is CRH (Corticotropin Releasing Hormone). The drugs Lamotrigine and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and brain, and related phenotype is homeostasis/metabolism.

Wikipedia : 71 Melancholia (from Greek: µέλαινα χολή, melaina chole), also lugubriousness, from the Latin... more...

Related Diseases for Melancholia

Diseases related to Melancholia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
id Related Disease Score Top Affiliating Genes
1 endogenous depression 11.2
2 intermittent squint 10.2 CRH PRL
3 nonparalytic poliomyelitis 10.2 CRH PRL
4 dacryoadenitis 10.2 CRH PRL
5 merkel cell carcinoma 10.2 CRH PRL
6 esophagus squamous cell papilloma 10.2 CRH PRL
7 infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations 10.2 CRH PRL
8 adult i blood group with or without congenital cataract 10.2 CRH PRL
9 immune system organ benign neoplasm 10.2 CRH PRL
10 adrenal cortical adenocarcinoma 10.2 CRH PRL
11 urethra clear cell adenocarcinoma 10.2 CRH PRL
12 fatty liver disease 10.2 CRH PRL
13 acute gonococcal salpingitis 10.2 CRH PRL
14 hypoglycemic coma 10.2 CRH IER3IP1
15 capillary lymphangioma 10.2 CRH PRL
16 cervix squamous papilloma 10.2 CRH PRL
17 alzheimer disease 17 10.2 CRH PRL
18 endocrine organ benign neoplasm 10.1 CRH PRL
19 xfe progeroid syndrome 10.1 HP TF
20 ivic syndrome 10.1 HP TF
21 maturity-onset diabetes of the young, type 14 10.1 HP TF
22 facial paresis, hereditary congenital, 1 10.1 HP TF
23 keratosis 10.1 CRH IER3IP1
24 larynx sarcoma 10.1 HP TF
25 fanconi anemia, complementation group c 10.1 HP TF
26 focal epithelial hyperplasia 10.1 HP TF
27 mucinous adenocarcinoma 10.1 PRL TF
28 meningeal melanocytoma 10.1 HP TF
29 alopecia 10.1 PRL TF
30 adamantinous craniopharyngioma 10.1 CRH PRL
31 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 10.1 CRH PRL
32 luxation of globe 10.0 CRP PRL
33 poems syndrome 10.0 CRP TF
34 harp syndrome 10.0 CRP TF
35 chronic eosinophilic pneumonia 10.0 CRH IER3IP1 PRL
36 astroblastoma 10.0 CRH HP PRL
37 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 10.0 CRP TF
38 breast hemangiopericytoma 10.0 CRP PRL
39 acro coxo mesomelic dysplasia 10.0 CRP HP
40 mood disorder 10.0
41 blind hypotensive eye 10.0 CRP TF
42 allergic bronchopulmonary aspergillosis 10.0 CRP IER3IP1
43 female breast upper-inner quadrant cancer 10.0 CRP HP
44 pigmentation disease 10.0 HP TF
45 brain injury 10.0 CRP IER3IP1
46 central nervous system leiomyoma 9.9 CRP TF
47 familial nephrotic syndrome 9.9 CRP TF
48 bile duct mucoepidermoid carcinoma 9.9 CRP TF
49 calcinosis 9.9 CRH CRP TF
50 cerebritis 9.9

Graphical network of the top 20 diseases related to Melancholia:



Diseases related to Melancholia

Symptoms & Phenotypes for Melancholia

MGI Mouse Phenotypes related to Melancholia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 AVPR1B CRH CRP HP PRL TF

Drugs & Therapeutics for Melancholia

Drugs for Melancholia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamotrigine Approved, Investigational Phase 4,Phase 3 84057-84-1 3878
2
Citalopram Approved Phase 4 59729-33-8 2771
3
Sertraline Approved Phase 4 79617-96-2 68617
4
Nortriptyline Approved Phase 4 72-69-5 4543
5
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
6
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
7
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
8
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
9 Quetiapine Fumarate Phase 4 111974-72-2
10 calcium channel blockers Phase 4,Phase 3
11
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
12 Serotonin Agents Phase 4,Phase 3,Phase 2
13 Adrenergic Agents Phase 4
14 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 2
15 Sodium Channel Blockers Phase 4,Phase 3
16 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
17 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
18 Tranquilizing Agents Phase 4,Phase 3,Phase 2
19 Diuretics, Potassium Sparing Phase 4,Phase 3
20 Duloxetine Hydrochloride Phase 4,Phase 3
21 Excitatory Amino Acid Antagonists Phase 4,Phase 3
22 Excitatory Amino Acids Phase 4,Phase 3
23 Anticonvulsants Phase 4,Phase 3
24 Antidepressive Agents Phase 4,Phase 3,Phase 2
25 Antidepressive Agents, Tricyclic Phase 4
26 Psychotropic Drugs Phase 4,Phase 3,Phase 2
27 Antipsychotic Agents Phase 4,Phase 3
28 Calcium, Dietary Phase 4,Phase 3
29 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
30 Vilazodone Hydrochloride Phase 4 163521-08-2
31 Desvenlafaxine Succinate Phase 4 386750-22-7
32 Venlafaxine Hydrochloride Phase 4
33
Norepinephrine Approved Phase 3 51-41-2 439260
34
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
35
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
36
Ziprasidone Approved Phase 3 146939-27-7 60854
37
Vortioxetine Approved Phase 3,Phase 2 508233-74-7 9966051
38 Analgesics Phase 3
39 Serotonin 5-HT1 Receptor Agonists Phase 3,Phase 2
40 Serotonin 5-HT3 Receptor Antagonists Phase 3,Phase 2
41 Serotonin Antagonists Phase 3,Phase 2
42 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
43 Peripheral Nervous System Agents Phase 3
44 Dopamine Agents Phase 3
45 Dopamine Antagonists Phase 3
46 Anti-Anxiety Agents Phase 3,Phase 2
47
Substance P Investigational Phase 2 33507-63-0 44359816
48 neurokinin A Phase 2
49
Epinephrine Approved, Vet_approved 51-43-4 5816
50
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311

Interventional clinical trials:

(show all 25)
id Name Status NCT ID Phase
1 Antidepressant Treatment of Melancholia in Late Life Completed NCT00000378 Phase 4
2 Quetiapine in Melancholic Depression Completed NCT01200901 Phase 4
3 Melancholic Symptoms in Bipolar Depression and Responsiveness to Lamotrigine Active, not recruiting NCT02989727 Phase 4
4 Effects of Treatment on Decision-making in Major Depression Active, not recruiting NCT01916824 Phase 4
5 Duloxetine in the Treatment of Melancholic Depression Completed NCT00191685 Phase 3
6 Depression And Bipolar Disorder Completed NCT00274677 Phase 3
7 Bipolar Disorder Study for Men and Women Completed NCT00056277 Phase 3
8 Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder Completed NCT00072774 Phase 3
9 Safety and Tolerability of Vortioxetine (LuAA21004) - Open Label Extension Study Completed NCT01152996 Phase 3
10 Efficacy and Safety Study of Vortioxetine (Lu AA21004) for Treatment of Major Depressive Disorder Completed NCT01255787 Phase 2, Phase 3
11 Efficacy and Safety Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT01163266 Phase 3
12 Safety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT01153009 Phase 3
13 A Study of the Effectiveness and Safety of Risperidone to Augment SSRI Therapy in Patients With Treatment-resistant Depression Completed NCT00044681 Phase 3
14 Safety and Tolerability of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT00707980 Phase 3
15 Efficacy Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT00735709 Phase 3
16 A Six-Week Flexible Dose Study Evaluating the Efficacy and Safety of Geodon in Patients With Bipolar I Depression. Completed NCT00282464 Phase 3
17 A Six-Week Study Evaluating The Efficacy And Safety Of Geodon In Patients With A Diagnosis Of Bipolar I Depression Completed NCT00141271 Phase 3
18 Serotonin Transporter Density in Late-life Depression With and Without Dementia Completed NCT01548937 Phase 2
19 Safety and Efficacy Study in Patients With Major Depressive Disorder Completed NCT00896363 Phase 2
20 A Study Of The Efficacy And Safety Of CP-601,927 Augmentation Of Antidepressant Therapy In Major Depression Terminated NCT01098240 Phase 2
21 A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed Dose Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder Terminated NCT00880399 Phase 2
22 A Randomised, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder Terminated NCT00880048 Phase 2
23 Effects of 3 Months of Selective Serotonin Reuptake Inhibitor (SSRI)-Treatment on Metabolism and Hypothalamic-pituitary-adrenal (HPA)-Axis in Young Men Born With Low Birth Weight Completed NCT00971815
24 Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression Completed NCT00001479
25 Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions Terminated NCT01307475

Search NIH Clinical Center for Melancholia

Genetic Tests for Melancholia

Anatomical Context for Melancholia

MalaCards organs/tissues related to Melancholia:

39
Testes, Pituitary, Brain, Eye, Thyroid, Cortex, Prefrontal Cortex

Publications for Melancholia

Articles related to Melancholia:

(show top 50) (show all 359)
id Title Authors Year
1
Retrospective: Pursuing melancholia - The Australian contribution. ( 28030975 )
2017
2
The properties and utility of the CORE measure of melancholia. ( 27721186 )
2017
3
Postpartum Psychosis: Madness, Mania, and Melancholia in Motherhood. ( 27609245 )
2016
4
The History of Melancholia Disease. ( 27840541 )
2016
5
Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression. ( 27259838 )
2016
6
Anticipatory Reward Deficits in Melancholia. ( 27175986 )
2016
7
Melancholia, Narcissism and Depression. ( 27377400 )
2016
8
THE SORROWS OF YOUNG WERTHER AND GOETHE'S UNDERSTANDING OF MELANCHOLIA. ( 26784722 )
2016
9
Associations of Serum Cytokine Receptor Levels with Melancholia, Staging of Illness, Depressive and Manic Phases, and Severity of Depression in Bipolar Disorder. ( 27660275 )
2016
10
The History of Melancholia Disease. ( 27516703 )
2016
11
Inaccessible Masturbation, Impossible Mourning: Collective Melancholia, the Prohibition on Female Sexual Subjects in India, and Masturbation Fantasy as a Zone of the Strange. ( 26653059 )
2015
12
Scene unseen: Disrupted neuronal adaptation in melancholia during emotional film viewing. ( 26740919 )
2015
13
Melancholia and catatonia: disorders or specifiers? ( 25417594 )
2015
14
Disrupted effective connectivity of cortical systems supporting attention and interoception in melancholia. ( 25692565 )
2015
15
Agoraphobia and Melancholia: Thoughts on Milrod's "Emptiness in Agoraphobia Patients". ( 26263925 )
2015
16
ON LOVE AND MELANCHOLIA IN MARGUERITE DURAS'S AUTOFICTION. ( 26198607 )
2015
17
Melancholia. ( 26499302 )
2015
18
Melancholia before the twentieth century: fear and sorrow or partial insanity? ( 25691879 )
2015
19
Melancholia Associated With Severe Cognitive Disorders as the Expression of Late-Onset Postpartum Anti-N-Methyl-d-Aspartic Acid Receptor Limbic Encephalitis. ( 25923872 )
2015
20
Association between core-assigned melancholia and the melancholia subscale of the HAM-D. ( 25451414 )
2014
21
Right temporal activation differs between melancholia and nonmelancholic depression: a multichannel near-infrared spectroscopy study. ( 24780385 )
2014
22
Melancholia: definition and management. ( 24270479 )
2014
23
Melancholia in medieval Persian literature: The view of Hidayat of Al-Akhawayni. ( 25019055 )
2014
24
Melancholia in later life: late and early onset differences in presentation, course, and dementia risk. ( 24677247 )
2014
25
Antidepressant treatment of melancholia in older adults. ( 24119858 )
2014
26
The impact of melancholia versus non-melancholia on resting-state, EEG alpha asymmetry: electrophysiological evidence for depression heterogeneity. ( 24467874 )
2014
27
Fewer study participants needed to demonstrate superior antidepressant efficacy when using the Hamilton melancholia subscale (HAM-D6) as outcome measure. ( 25487682 )
2014
28
Psychometric analysis of the Melancholia Scale in trials with non-pharmacological augmentation of patients with therapy-resistant depression. ( 25142191 )
2014
29
Brief, unidimensional melancholia rating scales are highly sensitive to the effect of citalopram and may have biological validity: implications for the research domain criteria (RDoC). ( 24836083 )
2014
30
Sifting through the sands of time: mourning and melancholia revisited via the documentary Nostalgia for the Light (2011). ( 24628289 )
2014
31
Microbiota, the immune system, black moods and the brain-melancholia updated. ( 25309394 )
2014
32
Major depressive disorder with melancholia displays robust alterations in resting state heart rate and its variability: implications for future morbidity and mortality. ( 25505893 )
2014
33
Loss of light in the eyes: a window to melancholia. ( 23751309 )
2013
34
Should psychomotor disturbance be an essential criterion for a DSM-5 diagnosis of melancholia? ( 23724792 )
2013
35
A case for reprising and redefining melancholia. ( 23547640 )
2013
36
Validation of a new prototypic measure of melancholia. ( 23602392 )
2013
37
The morbidity and mortality linked to melancholia: two cohorts compared, 1875-1924 and 1995-2005. ( 24572794 )
2013
38
Melancholia: a distinct entity? ( 23547639 )
2013
39
Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias. ( 23639523 )
2013
40
Treating melancholia at home: theoretical wisdom and grim reality in the career of E.C. Seguin. ( 23628930 )
2013
41
From Statistics to Diagnostics: Medical Certificates, Melancholia, and "Suicidal Propensities" in Victorian Psychiatry. ( 24293701 )
2013
42
Melancholia: past and present. ( 23547641 )
2013
43
Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression. ( 21945535 )
2012
44
Melancholia in Janet Frame's Faces in the Water. ( 22870608 )
2012
45
Mapping melancholia: the continuing typological challenge for major depression. ( 21377737 )
2012
46
Psychometric validation and clinical validity of the Minor Melancholia Mood Checklist (MMCL-32). ( 22244379 )
2012
47
The interdependence of subtype and severity: contributions of clinical and neuropsychological features to melancholia and non-melancholia in an outpatient sample. ( 22300644 )
2012
48
Melancholia. ( 22156933 )
2012
49
From mania and melancholia to the bipolar disorders spectrum: a brief history of controversy. ( 22508590 )
2012
50
Bringing melancholia out of the shadows. ( 23429807 )
2012

Variations for Melancholia

Expression for Melancholia

Search GEO for disease gene expression data for Melancholia.

Pathways for Melancholia

GO Terms for Melancholia

Cellular components related to Melancholia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 CRH CRP HP PRL TF

Biological processes related to Melancholia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.32 CRH PRL
2 cellular response to hormone stimulus GO:0032870 9.26 AVPR1B PRL
3 positive regulation of cell death GO:0010942 9.16 CRH HP
4 acute-phase response GO:0006953 8.96 CRP HP
5 parturition GO:0007567 8.62 CRH PRL

Molecular functions related to Melancholia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CRH PRL

Sources for Melancholia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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