Aliases & Classifications for Melancholia

MalaCards integrated aliases for Melancholia:

Name: Melancholia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2848
MeSH 41 D003866
NCIt 46 C34812
SNOMED-CT 64 35489007
UMLS 69 C0025193

Summaries for Melancholia

MalaCards based summary : Melancholia is related to endogenous depression and major depressive disorder. An important gene associated with Melancholia is CRH (Corticotropin Releasing Hormone), and among its related pathways/superpathways are amb2 Integrin signaling and Overview of nanoparticle effects. The drugs Nortriptyline and Sertraline have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and brain.

Wikipedia : 72 Melancholia (from Greek: µέλαινα χολή, melaina chole), also lugubriousness, from the Latin lugere, to... more...

Related Diseases for Melancholia

Diseases related to Melancholia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 endogenous depression 32.4 CRH IER3IP1
2 major depressive disorder 29.9 CRH PRL TNF
3 hypothalamic disease 10.4 CRH PRL
4 nelson syndrome 10.4 CRH PRL
5 sheehan syndrome 10.4 CRH PRL
6 acth-secreting pituitary adenoma 10.4 CRH PRL
7 adrenal cortex disease 10.4 CRH PRL
8 adrenal gland disease 10.4 CRH PRL
9 postpartum depression 10.4 CRH PRL
10 pituitary-dependent cushing's disease 10.4 CRH PRL
11 endocrine organ benign neoplasm 10.4 CRH PRL
12 adrenal gland hyperfunction 10.4 CRH PRL
13 pituitary gland disease 10.3 CRH PRL
14 diabetes insipidus 10.3 CRH PRL
15 amenorrhea 10.3 CRH PRL
16 mental depression 10.3 CRH IER3IP1
17 hypopituitarism 10.3 CRH PRL
18 congenital disorder of glycosylation, type ia 10.3 HP TF
19 epileptic encephalopathy, early infantile, 36 10.2 HP TF
20 bulimia nervosa 2 10.2 CRH PRL
21 substance abuse 10.2 PRL TF
22 fructose intolerance, hereditary 10.2 HP TF
23 atransferrinemia 10.2 HP TF
24 testicular yolk sac tumor 10.2 HP TF
25 intermittent explosive disorder 10.2 CRP PRL
26 sleeping sickness 10.2 HP TF
27 hemoglobinopathy 10.2 HP TF
28 folic acid deficiency anemia 10.2 CRP TF
29 congenital hemolytic anemia 10.2 HP TF
30 sleep disorder 10.2 CRP PRL
31 analbuminemia 10.2 CRP TF
32 alcohol abuse 10.2 PRL TF
33 acquired angioedema 10.1 CRP HP
34 aging 10.1
35 mood disorder 10.1
36 iron deficiency anemia 10.1 CRP TF
37 acute cystitis 10.1 CRP IER3IP1
38 dirofilariasis 10.1 CRP HP
39 skeletal tuberculosis 10.1 CRP HP
40 burns 10.1 CRH TNF
41 bladder disease 10.1 CRP IER3IP1
42 post-traumatic stress disorder 10.1 CRH CRP
43 nutritional deficiency disease 10.1 CRP TF
44 inherited metabolic disorder 10.0 CRP TF
45 haemophilus influenzae 10.0 TF TNF
46 radiation proctitis 10.0 TF TNF
47 eales disease 10.0 TF TNF
48 premenstrual tension 10.0 CRH HP PRL
49 irritable bowel syndrome 10.0 CRH TNF
50 protein-energy malnutrition 10.0 TF TNF

Graphical network of the top 20 diseases related to Melancholia:



Diseases related to Melancholia

Symptoms & Phenotypes for Melancholia

Drugs & Therapeutics for Melancholia

Drugs for Melancholia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nortriptyline Approved Phase 4 72-69-5 4543
2
Sertraline Approved Phase 4 79617-96-2 68617
3
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
4
Citalopram Approved Phase 4 59729-33-8 2771
5
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
6
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
7
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
8
Lamotrigine Approved, Investigational Phase 4,Phase 3 84057-84-1 3878
9 Adrenergic Agents Phase 4
10 Antidepressive Agents Phase 4,Phase 3,Phase 2
11 Antidepressive Agents, Tricyclic Phase 4
12 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
13 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
14 Psychotropic Drugs Phase 4,Phase 3,Phase 2
15
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
16 Serotonin Agents Phase 4,Phase 3,Phase 2
17 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 2
18 Antipsychotic Agents Phase 4,Phase 3
19 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
20 Quetiapine Fumarate Phase 4 111974-72-2
21 Tranquilizing Agents Phase 4,Phase 3,Phase 2
22 Desvenlafaxine Succinate Phase 4 386750-22-7
23 Duloxetine Hydrochloride Phase 4,Phase 3
24 Venlafaxine Hydrochloride Phase 4
25 Vilazodone Hydrochloride Phase 4 163521-08-2
26 Anticonvulsants Phase 4,Phase 3
27 calcium channel blockers Phase 4,Phase 3
28 Calcium, Dietary Phase 4,Phase 3
29 Diuretics, Potassium Sparing Phase 4,Phase 3
30 Excitatory Amino Acid Antagonists Phase 4,Phase 3
31 Excitatory Amino Acids Phase 4,Phase 3
32 Sodium Channel Blockers Phase 4,Phase 3
33
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
34
Norepinephrine Approved Phase 3 51-41-2 439260
35
Vortioxetine Approved, Investigational Phase 3,Phase 2 508233-74-7 9966051
36
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
37
Ziprasidone Approved Phase 3 146939-27-7 60854
38 Analgesics Phase 3
39 Dopamine Agents Phase 3
40 Peripheral Nervous System Agents Phase 3
41 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
42 Anti-Anxiety Agents Phase 3,Phase 2
43 Serotonin 5-HT1 Receptor Agonists Phase 3,Phase 2
44 Serotonin 5-HT3 Receptor Antagonists Phase 3,Phase 2
45 Serotonin Antagonists Phase 3,Phase 2
46 Dopamine Antagonists Phase 3
47
Substance P Investigational Phase 2 33507-63-0 44359816
48 neurokinin A Phase 2
49
Epinephrine Approved, Vet_approved 51-43-4 5816
50 Racepinephrine Approved 329-65-7

Interventional clinical trials:

(show all 29)

# Name Status NCT ID Phase Drugs
1 Antidepressant Treatment of Melancholia in Late Life Completed NCT00000378 Phase 4 Sertraline;Nortriptyline
2 Quetiapine in Melancholic Depression Completed NCT01200901 Phase 4 Quetiapine
3 Effects of Treatment on Decision-making in Major Depression Completed NCT01916824 Phase 4 Any FDA Approved Antidepressant
4 Melancholic Depression and Insomnia as Predictors of Response to Quetiapine in Patients With Major Depression Active, not recruiting NCT03207438 Phase 4 Quetiapine 50 MG Extended Release Oral Tablet;Quetiapine Fumarate XR 150-300 mg;Placebos
5 Melancholic Symptoms in Bipolar Depression and Responsiveness to Lamotrigine Active, not recruiting NCT02989727 Phase 4 Lamotrigine;Placebos
6 Duloxetine in the Treatment of Melancholic Depression Completed NCT00191685 Phase 3 duloxetine
7 Depression And Bipolar Disorder Completed NCT00274677 Phase 3 Placebo;lamotrigine
8 Bipolar Disorder Study for Men and Women Completed NCT00056277 Phase 3 lamotrigine
9 Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder Completed NCT00072774 Phase 3 DVS-233 SR
10 Safety and Tolerability of Vortioxetine (LuAA21004) - Open Label Extension Study Completed NCT01152996 Phase 3 Vortioxetine
11 Efficacy and Safety Study of Vortioxetine (Lu AA21004) for Treatment of Major Depressive Disorder Completed NCT01255787 Phase 2, Phase 3 Vortioxetine;Placebo
12 Efficacy and Safety Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT01163266 Phase 3 Vortioxetine;Placebo
13 Safety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT01153009 Phase 3 Vortioxetine;Duloxetine;Placebo
14 A Study of the Effectiveness and Safety of Risperidone to Augment SSRI Therapy in Patients With Treatment-resistant Depression Completed NCT00044681 Phase 3 risperidone
15 Safety and Tolerability of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT00707980 Phase 3 Vortioxetine
16 Efficacy Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT00735709 Phase 3 Vortioxetine;Placebo
17 A Six-Week Flexible Dose Study Evaluating the Efficacy and Safety of Geodon in Patients With Bipolar I Depression. Completed NCT00282464 Phase 3 Placebo;Geodon (Ziprasidone)
18 A Six-Week Study Evaluating The Efficacy And Safety Of Geodon In Patients With A Diagnosis Of Bipolar I Depression Completed NCT00141271 Phase 3 Geodon (Ziprasidone);Geodon (Ziprasidone);Placebo
19 Serotonin Transporter Density in Late-life Depression With and Without Dementia Completed NCT01548937 Phase 2 I-123 ADAM
20 A Study of the Effects of a New Antidepressant Treatment (GSK561679) in Females With Major Depressive Disorder Completed NCT00733980 Phase 2 GSK561679
21 Safety and Efficacy Study in Patients With Major Depressive Disorder Completed NCT00896363 Phase 2 GSK163090 Tablets;GSK163090 Placebo Tablets
22 A Study Of The Efficacy And Safety Of CP-601,927 Augmentation Of Antidepressant Therapy In Major Depression Terminated NCT01098240 Phase 2 CP-601,927
23 A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed Dose Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder Terminated NCT00880399 Phase 2 orvepitant
24 A Randomised, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder Terminated NCT00880048 Phase 2 orvepitant
25 Effects of 3 Months of Selective Serotonin Reuptake Inhibitor (SSRI)-Treatment on Metabolism and Hypothalamic-pituitary-adrenal (HPA)-Axis in Young Men Born With Low Birth Weight Completed NCT00971815 Escitalopram;placebo
26 Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression Completed NCT00001479
27 Stepped Care aiTBS 2 Depression Study (Ghent) Recruiting NCT03288675 SSRI
28 Movement for Depression - An RCT Assessing the Effects of Physical Activity Promotion for People With MDD Recruiting NCT03403881
29 Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions Terminated NCT01307475

Search NIH Clinical Center for Melancholia

Genetic Tests for Melancholia

Anatomical Context for Melancholia

MalaCards organs/tissues related to Melancholia:

38
Testes, Pituitary, Brain, Eye, Prefrontal Cortex, Thyroid, Cortex

Publications for Melancholia

Articles related to Melancholia:

(show top 50) (show all 370)
# Title Authors Year
1
Lipid Peroxidation and Immune Biomarkers Are Associated with Major Depression and Its Phenotypes, Including Treatment-Resistant Depression and Melancholia. ( 29103192 )
2018
2
Putamen Volume Differences Among Older Adults: Depression Status, Melancholia, and Age. ( 29251178 )
2018
3
To define melancholia, follow the path of catatonia. ( 28691306 )
2017
4
Defining melancholia: A core mood disorder. ( 28599349 )
2017
5
Retrospective: Pursuing melancholia - The Australian contribution. ( 28030975 )
2017
6
The genealogy of major depression: symptoms and signs of melancholia from 1880 to 1900. ( 28785109 )
2017
7
The properties and utility of the CORE measure of melancholia. ( 27721186 )
2017
8
Love and melancholia in the analysis of women by women. ( 28671276 )
2017
9
Social death, melancholia, and zombies: Same patterns? ( 28351493 )
2017
10
The Devolution of Melancholia Into Psychosis: The Case of a Child Whose Mother Was Unable to Grieve. ( 29022850 )
2017
11
Debate on "Defining melancholia: A core mood disorder". ( 28987022 )
2017
12
Are there differences in lipid peroxidation and immune biomarkers between major depression and bipolar disorder: Effects of melancholia, atypical depression, severity of illness, episode number, suicidal ideation and prior suicide attempts. ( 28867391 )
2017
13
Melancholia, Narcissism and Depression. ( 27377400 )
2016
14
Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression. ( 27259838 )
2016
15
THE SORROWS OF YOUNG WERTHER AND GOETHE'S UNDERSTANDING OF MELANCHOLIA. ( 26784722 )
2016
16
The History of Melancholia Disease. ( 27516703 )
2016
17
Anticipatory Reward Deficits in Melancholia. ( 27175986 )
2016
18
Associations of Serum Cytokine Receptor Levels with Melancholia, Staging of Illness, Depressive and Manic Phases, and Severity of Depression in Bipolar Disorder. ( 27660275 )
2016
19
The History of Melancholia Disease. ( 27840541 )
2016
20
Melancholia, Narcissism and Depression. ( 28638134 )
2016
21
Postpartum Psychosis: Madness, Mania, and Melancholia in Motherhood. ( 27609245 )
2016
22
Scene unseen: Disrupted neuronal adaptation in melancholia during emotional film viewing. ( 26740919 )
2015
23
Melancholia. ( 26499302 )
2015
24
Inaccessible Masturbation, Impossible Mourning: Collective Melancholia, the Prohibition on Female Sexual Subjects in India, and Masturbation Fantasy as a Zone of the Strange. ( 26653059 )
2015
25
Melancholia Associated With Severe Cognitive Disorders as the Expression of Late-Onset Postpartum Anti-N-Methyl-d-Aspartic Acid Receptor Limbic Encephalitis. ( 25923872 )
2015
26
Melancholia before the twentieth century: fear and sorrow or partial insanity? ( 25691879 )
2015
27
Agoraphobia and Melancholia: Thoughts on Milrod's "Emptiness in Agoraphobia Patients". ( 26263925 )
2015
28
Melancholia and catatonia: disorders or specifiers? ( 25417594 )
2015
29
ON LOVE AND MELANCHOLIA IN MARGUERITE DURAS'S AUTOFICTION. ( 26198607 )
2015
30
Disrupted effective connectivity of cortical systems supporting attention and interoception in melancholia. ( 25692565 )
2015
31
Sifting through the sands of time: mourning and melancholia revisited via the documentary Nostalgia for the Light (2011). ( 24628289 )
2014
32
Melancholia in medieval Persian literature: The view of Hidayat of Al-Akhawayni. ( 25019055 )
2014
33
Psychometric analysis of the Melancholia Scale in trials with non-pharmacological augmentation of patients with therapy-resistant depression. ( 25142191 )
2014
34
Major depressive disorder with melancholia displays robust alterations in resting state heart rate and its variability: implications for future morbidity and mortality. ( 25505893 )
2014
35
Association between core-assigned melancholia and the melancholia subscale of the HAM-D. ( 25451414 )
2014
36
Microbiota, the immune system, black moods and the brain-melancholia updated. ( 25309394 )
2014
37
Antidepressant treatment of melancholia in older adults. ( 24119858 )
2014
38
The impact of melancholia versus non-melancholia on resting-state, EEG alpha asymmetry: electrophysiological evidence for depression heterogeneity. ( 24467874 )
2014
39
Melancholia: definition and management. ( 24270479 )
2014
40
Right temporal activation differs between melancholia and nonmelancholic depression: a multichannel near-infrared spectroscopy study. ( 24780385 )
2014
41
Brief, unidimensional melancholia rating scales are highly sensitive to the effect of citalopram and may have biological validity: implications for the research domain criteria (RDoC). ( 24836083 )
2014
42
Fewer study participants needed to demonstrate superior antidepressant efficacy when using the Hamilton melancholia subscale (HAM-D6) as outcome measure. ( 25487682 )
2014
43
Melancholia in later life: late and early onset differences in presentation, course, and dementia risk. ( 24677247 )
2014
44
A case for reprising and redefining melancholia. ( 23547640 )
2013
45
Melancholia: past and present. ( 23547641 )
2013
46
Should psychomotor disturbance be an essential criterion for a DSM-5 diagnosis of melancholia? ( 23724792 )
2013
47
Treating melancholia at home: theoretical wisdom and grim reality in the career of E.C. Seguin. ( 23628930 )
2013
48
From Statistics to Diagnostics: Medical Certificates, Melancholia, and "Suicidal Propensities" in Victorian Psychiatry. ( 24293701 )
2013
49
Loss of light in the eyes: a window to melancholia. ( 23751309 )
2013
50
Validation of a new prototypic measure of melancholia. ( 23602392 )
2013

Variations for Melancholia

Expression for Melancholia

Search GEO for disease gene expression data for Melancholia.

Pathways for Melancholia

Pathways related to Melancholia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.84 HP TNF
2 10.23 CRP TNF
3 9.58 PRL TNF

GO Terms for Melancholia

Cellular components related to Melancholia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CRH CRP HP TF TNF
2 extracellular region GO:0005576 9.1 CRH CRP HP PRL TF TNF

Biological processes related to Melancholia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.54 CRH CRP TNF
2 positive regulation of gene expression GO:0010628 9.5 CRH CRP TNF
3 positive regulation of cell death GO:0010942 9.26 CRH HP
4 negative regulation of endothelial cell proliferation GO:0001937 9.16 PRL TNF
5 acute-phase response GO:0006953 8.96 CRP HP
6 negative regulation of lipid storage GO:0010888 8.62 CRP TNF

Sources for Melancholia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....