MCID: MLN003
MIFTS: 48

Melancholia malady

Mental diseases category

Summaries for Melancholia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Melancholia (from Greek ?????????? melancholia \"sadness\", literally black bile), also lugubriousness,... more...

MalaCards: Melancholia is related to endogenous depression and mood disorder. An important gene associated with Melancholia is AVPR1B (arginine vasopressin receptor 1B), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Cytochrome P450 - arranged by substrate type. The compounds pitressin and acth 1-24 have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and brain, and related mouse phenotypes are growth/size/body and integument.

Aliases & Classifications for Melancholia

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

melancholia 9 11 63


External Ids:

Disease Ontology9 DOID:2848
NCIt41 C34812
SNOMED-CT59 35489007
MeSH36 D003866

Related Diseases for Melancholia

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18GeneCards, 19GeneDecks
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Diseases related to Melancholia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1endogenous depression30.8SLC6A4, CRH
2mood disorder30.3POMC, MAOA, CRH, SLC6A4, TRH
3thyroiditis30.1POMC, TRH
4addison's disease30.0CRH, POMC
5seasonal affective disorder30.0SLC6A4, CRH
6personality disorder30.0MAOA, SLC6A4
7borderline personality disorder30.0MAOA, SLC6A4
8bipolar disorder30.0SLC6A4, CRH, MAOA
9schizophrenia29.9PRL, MAOA, SLC6A4, TRH
10blindness10.4
11major depressive disorder10.3
12cerebritis10.2
13asthma10.1
14exophthalmos10.1TRH
15euthyroid sick syndrome10.1TRH
16hyperthyroxinemia10.1TRH
17serotonin syndrome10.1MAOA
18adrenal carcinoma10.1POMC
19skin disease10.1POMC
20premature ejaculation10.1SLC6A4
21pervasive developmental disorder10.1SLC6A4
22asperger syndrome10.1SLC6A4
23gonadal disease10.1POMC, CRH
24cushing's syndrome10.1POMC, CRH
25hypoadrenalism10.1POMC, CRH
26infantile epileptic encephalopathy10.1POMC, CRH
27hypothalamic disease10.0PRL, CRH
28congenital adrenal hyperplasia10.0CRH, POMC
29pituitary carcinoma10.0PRL, POMC
30neurogenic diabetes insipidus10.0POMC, PRL
31thyrotropin deficiency, isolated10.0POMC, PRL
32panhypopituitarism10.0POMC, PRL
33substance abuse10.0CRH, SLC6A4
34klinefelter's syndrome10.0PRL, TRH
35adrenocortical carcinoma10.0CRH, POMC
36antisocial personality disorder10.0MAOA, SLC6A4
37vitiligo10.0MAOA, POMC
38precocious puberty10.0POMC, PRL
39adrenal adenoma10.0CRH, POMC
40social phobia10.0MAOA, SLC6A4
41primary hyperoxaluria10.0POMC, CRH, TRH
42fibromyalgia10.0CRH, SLC6A4
43pain agnosia10.0POMC, CRH
44drug dependence10.0MAOA, SLC6A4
45generalized anxiety disorder10.0MAOA, SLC6A4
46conduct disorder10.0MAOA, SLC6A4
47bulimia nervosa10.0MAOA, SLC6A4
48gilles de la tourette syndrome10.0MAOA, SLC6A4
49irritable bowel syndrome10.0CRH, SLC6A4
50obsessive-compulsive disorder10.0MAOA, SLC6A4

Graphical network of the top 20 diseases related to Melancholia:



Diseases related to melancholia

Symptoms for Melancholia

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Drugs & Therapeutics for Melancholia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Melancholia

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Anatomical Context for Melancholia

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34MalaCards
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MalaCards organs/tissues related to Melancholia:

34
Testes, Pituitary, Brain, Eye, Thyroid, Cortex, Prefrontal cortex

Animal Models for Melancholia or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Melancholia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.7TRH, SLC6A4, CRH, POMC, TNF
2MP:00107717.4TNF, POMC, PRL, CRH, SLC6A4
3MP:00053796.9AVPR1B, TNF, POMC, PRL, CRH, SLC6A4
4MP:00053866.8AVPR1B, TNF, POMC, PRL, MAOA, CRH
5MP:00036316.5TRH, AVPR1B, TNF, POMC, PRL, MAOA
6MP:00053766.4AVPR1B, TNF, POMC, PRL, MAOA, CRH

Publications for Melancholia

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53PubMed
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Articles related to Melancholia:

(show top 50)    (show all 321)
idTitleAuthorsYear
1
Melancholia: past and present. (23547641)
2013
2
The interdependence of subtype and severity: contributions of clinical and neuropsychological features to melancholia and non-melancholia in an outpatient sample. (22300644)
2012
3
Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression. (21945535)
2012
4
Electroconvulsive therapy and melancholia: review of the literature and suggestions for further study. (21673591)
2011
5
The incidence and prevalence of admissions for melancholia in two cohorts (1875-1924 and 1995-2005). (21733576)
2011
6
Issues for DSM-5: whither melancholia? The case for its classification as a distinct mood disorder. (20595426)
2010
7
Mother, melancholia, and humor in Erik H. Erikson's earliest writings. (19105029)
2008
8
A mixed state core for melancholia: an exploration in history, art and clinical science. (17280570)
2007
9
Resurrecting melancholia. (17280566)
2007
10
In search of Aristotle: temperament, human nature, melancholia, creativity and eminence. (17499855)
2007
11
As a prelude: bringing melancholia to book. (16878733)
2006
12
Black bile and psychomotor retardation: shades of melancholia in Dante's Inferno. (15370340)
2004
13
Functional but not structural subgenual prefrontal cortex abnormalities in melancholia. (14699431)
2004
14
The prolactin response to fenfluramine in depression: effects of melancholia and baseline cortisol. (12680745)
2003
15
The stress response and the hypothalamic-pituitary-adrenal axis: from molecule to melancholia. (10873181)
2000
16
TCM treatment with the modified wendan tang in 40 cases of melancholia. (10921137)
1999
17
Once vs. three times weekly ECT in melancholia: a randomized controlled trial. (9821454)
1998
18
Variability in the serotonin transporter gene and increased risk for major depression with melancholia. (9799087)
1998
19
Sub-typing depression, III. Development of a clinical algorithm for melancholia and comparison with other diagnostic measures. (7480461)
1995
20
Music and melancholia. (7853306)
1994
21
A double-blind comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia. The Venlafaxine French Inpatient Study Group. (7814822)
1994
22
A modern melancholia: Van Gogh's portrait of Dr Gachet. (8234566)
1993
23
Response to somatic treatment and placebo in patients with melancholia/endogenous depression. (8280275)
1993
24
The anatomy of melancholia--focal abnormalities of cerebral blood flow in major depression. (1410086)
1992
25
Time experience in melancholia: a comparison between findings based on phenomenology and experimental psychology. (1935022)
1991
26
Time estimation and the experience of time in endogenous depression (Melancholia): an experimental investigation. (2023986)
1991
27
Prediction of ECT Response in Melancholia. (11941106)
1991
28
Factor study of the Hamilton Rating Scale for Depression and the Bech Melancholia Scale. (2239363)
1990
29
Corticotropin, cortisol and beta-endorphin responses to the human corticotropin-releasing hormone during melancholia and after unilateral electroconvulsive therapy. (2174200)
1990
30
Results of the 8 a.m. dexamethasone suppression test constitute a suitable tool for confirming the diagnosis of melancholia. A test unaffected by the variations in the bioavailability of dexamethasone. (2639285)
1989
31
The current age of youthful melancholia. Evidence for increase in depression among adolescents and young adults. (3167377)
1988
32
Relationships of the dexamethasone suppression test to clinical severity and degree of melancholia. (3697434)
1986
33
Hypochondriacal fears and beliefs in DSM-III melancholia. Changes with amitriptyline. (2939120)
1986
34
DSM-III melancholia: do the criteria accurately and reliably distinguish endogenous pattern depression? (2943772)
1986
35
The tyramine challenge test as a marker for melancholia. (6732426)
1984
36
Attribution style, the dexamethasone suppression test, and the diagnosis of melancholia in depressed inpatients. (6512083)
1984
37
Comparative diagnostic criteria for melancholia and endogenous depression. (6721673)
1984
38
Dexamethasone suppression tests in antidepressant treatment of melancholia. The process of normalization and test-retest reproducibility. (6340634)
1983
39
The "myth' of involutional melancholia. (7043302)
1982
40
Fluctuating postdexamethasone cortisol levels in a patient with melancholia. (7055259)
1982
41
Depression: a multivariate study of Sir Aubrey Lewis's data on melancholia. (336020)
1977
42
Mental hospital admissions in England and Wales 1950-60 for all diagnoses, manic depressive reaction and involutional melancholia. (6072175)
1967
43
Melancholia: diagnostic hints. (13863481)
1962
44
Investigations on the aetiology of involutional melancholia. (14430414)
1959
45
Iproniazid chemotherapy in melancholia. (13583240)
1958
46
Involutional melancholia and depressive states: results of treatment over a 5-year period. (14888627)
1951
47
Involutional melancholia and convulsive therapy. (18135401)
1949
48
Personality adjustment following hospital treatment in patients with involutional psychosis, melancholia. (18911132)
1948
49
The prognosis and treatment of melancholia. (20287236)
1947
50
A Case of Melancholia, Associated with, and Perhaps Due to, Addison's Disease. (20744702)
1867

Variations for Melancholia

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Expression for genes affiliated with Melancholia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Melancholia

Search GEO for disease gene expression data for Melancholia.

Pathways for genes affiliated with Melancholia

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Sources:
51PathCards, 52PharmGKB, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG
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Pathways related to Melancholia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CRH, POMC
2
Show member pathways
9.6MAOA, POMC
39.5PRL, POMC
4
Show member pathways
9.5POMC, TRH
59.4MAOA, SLC6A4
69.2POMC, TNF
78.6TNF, MAOA, SLC6A4
8
Show member pathways
Serotonin Transporter Activity39
8.6SLC6A4, MAOA, TNF
9
Show member pathways
8.3CRH, MAOA, PRL, TNF
10
Show member pathways
8.3TRH, CRH, PRL, POMC, AVPR1B
11
Show member pathways
8.3AVPR1B, POMC, PRL, CRH, TRH

Compounds for genes affiliated with Melancholia

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Sources:
46Novoseek, 30IUPHAR, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Melancholia according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1pitressin469.6POMC, CRH
2acth 1-24469.5CRH, PRL, POMC
311 deoxycortisol469.5PRL, CRH, POMC
4hexarelin46 3010.5POMC, PRL, CRH
5desmopressin46 62 30 1212.4CRH, POMC, AVPR1B
6alprazolam46 1210.4CRH, MAOA, POMC
7naltrexone46 30 52 1212.4POMC, PRL, CRH
8pyridostigmine46 1210.4TRH, CRH, PRL
9sulpiride46 30 1211.4TRH, CRH, PRL
10hcrh469.3CRH, POMC
1117-hydroxyprogesterone46 2510.3PRL, POMC, CRH
125-hydroxyindoleacetic acid46 2510.3SLC6A4, CRH, MAOA
135-hydroxytryptophan469.3CRH, PRL, SLC6A4
14mdma469.3PRL, MAOA, SLC6A4
15maoa469.3SLC6A4, MAOA, POMC
16dehydroepiandrosterone sulfate469.2PRL, POMC, CRH
17diazepam46 30 52 1212.1TRH, CRH, POMC
18paroxetine46 52 30 1212.1SLC6A4, MAOA, PRL
19bromocriptine46 30 1211.1PRL, TRH, POMC
20sertraline46 30 52 25 1213.1SLC6A4, CRH, MAOA, POMC
21naloxone46 30 52 1212.0CRH, TRH, POMC, PRL
22mhpg469.0CRH, MAOA, SLC6A4, PRL
23homovanillic acid46 2510.0CRH, MAOA, PRL, SLC6A4
24clomipramine46 52 1211.0SLC6A4, PRL, MAOA, CRH
25octreotide46 62 30 1212.0CRH, POMC, PRL, TRH
26desipramine46 52 1211.0CRH, TRH, SLC6A4, MAOA
27fluoxetine46 52 30 1212.0SLC6A4, CRH, MAOA, PRL
28citalopram46 52 25 1211.9CRH, PRL, SLC6A4, MAOA
29mirtazapine46 52 1210.9SLC6A4, CRH, PRL, POMC
30amphetamine46 52 1210.9SLC6A4, MAOA, POMC
31opiate468.9PRL, SLC6A4, POMC, CRH
32thyroxine46 259.8TRH, CRH, POMC, PRL
33clonidine46 52 30 1211.7TRH, POMC, PRL, SLC6A4
34haloperidol46 52 30 3 1212.7TRH, POMC, PRL, SLC6A4
35carbamazepine46 52 1210.7POMC, PRL, CRH, TNF
36acth468.7POMC, TRH, CRH, PRL, AVPR1B
37corticosterone46 62 2510.6SLC6A4, CRH, PRL, POMC, AVPR1B
385-hydroxytryptamine468.5POMC, MAOA, PRL, CRH, SLC6A4
39gaba468.5POMC, MAOA, CRH, SLC6A4, TRH
40epinephrine46 25 1210.5PRL, MAOA, SLC6A4, CRH, POMC
41fenfluramine46 30 1210.4TRH, CRH, POMC, PRL, SLC6A4
42cocaine46 129.4PRL, CRH, SLC6A4, TRH, POMC
43gnrh468.4POMC, PRL, CRH, SLC6A4, TRH
44hydrocortisone46 3 62 1211.2TNF, TRH, CRH, PRL, POMC
45norepinephrine46 25 1210.0TRH, MAOA, SLC6A4, POMC, CRH, PRL
46dopamine46 30 25 1211.0POMC, TRH, SLC6A4, CRH, MAOA, PRL
47arginine468.0AVPR1B, PRL, CRH, SLC6A4, TRH, POMC
48testosterone46 62 25 1211.0SLC6A4, POMC, PRL, TRH, CRH, MAOA
49estrogen467.9TRH, POMC, SLC6A4, CRH, MAOA, PRL
50dexamethasone46 52 30 1210.7TNF, POMC, PRL, MAOA, CRH, TRH

GO Terms for genes affiliated with Melancholia

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17Gene Ontology
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Cellular components related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.5TRH, POMC
2extracellular regionGO:0055768.8TRH, CRH, POMC

Biological processes related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to corticosteroneGO:0514129.6TRH, CRH
2response to ethanolGO:0454719.6TRH, CRH
3female pregnancyGO:0075659.3CRH, PRL
4negative regulation of gene expressionGO:0106299.2CRH, TNF
5response to drugGO:0424938.7TNF, CRH, SLC6A4
6response to hypoxiaGO:0016668.6TRH, SLC6A4, TNF

Molecular functions related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6TRH, CRH
2hormone activityGO:0051798.8CRH, PRL, POMC

Products for genes affiliated with Melancholia

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Sources for Melancholia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet