Aliases & Classifications for Melancholia

MalaCards integrated aliases for Melancholia:

Name: Melancholia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2848
MeSH 42 D003866
NCIt 47 C34812
SNOMED-CT 64 35489007
UMLS 69 C0025193

Summaries for Melancholia

MalaCards based summary : Melancholia is related to endogenous depression and intermittent squint. An important gene associated with Melancholia is CRH (Corticotropin Releasing Hormone), and among its related pathways/superpathways are amb2 Integrin signaling and Overview of nanoparticle effects. The drugs Nortriptyline and Sertraline have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and brain.

Wikipedia : 72 Melancholia (from Greek: µέλαινα χολή, melaina chole), also lugubriousness, from the Latin lugere, to... more...

Related Diseases for Melancholia

Diseases related to Melancholia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
id Related Disease Score Top Affiliating Genes
1 endogenous depression 31.8 HP TNF
2 intermittent squint 10.6 CRH PRL
3 actinobacillosis 10.6 CRH PRL
4 ulcerative blepharitis 10.6 CRH PRL
5 trabecular follicular adenocarcinoma 10.6 CRH PRL
6 bronchiectasis 10.6 CRH PRL
7 cold-induced sweating syndrome 2 10.6 CRH PRL
8 cardiovascular organ benign neoplasm 10.6 CRH PRL
9 acute myocarditis 10.6 CRH PRL
10 acute myeloid leukemia, susceptibility, gata2-related 10.6 CRH PRL
11 adrenal cortex disease 10.5 CRH PRL
12 vestibular gland benign neoplasm 10.5 CRH PRL
13 uterine ligament clear cell adenocarcinoma 10.5 CRH PRL
14 hypertensive encephalopathy 10.5 CRH PRL
15 acute gonococcal salpingitis 10.5 CRH PRL
16 keratosis 10.4 CRH IER3IP1
17 xeroderma pigmentosum, group f 10.4 HP TF
18 mental retardation, x-linked, syndromic 15 10.4 HP TF
19 hypoglycemic coma 10.4 CRH IER3IP1
20 colon mucinous adenocarcinoma 10.4 PRL TF
21 allergic asthma 10.4 CRH PRL
22 maturity-onset diabetes of the young, type 14 10.4 HP TF
23 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 10.4 HP TF
24 spinal muscular atrophy, lower extremity-predominant, 2, ad 10.4 HP TF
25 sleep disorder 10.4 HP TF
26 luxation of globe 10.3 CRP PRL
27 endometrial adenocarcinoma 10.3 HP TF
28 poems syndrome 10.3 CRP TF
29 harp syndrome 10.3 CRP TF
30 colonic disease 10.3 CRP PRL
31 microcephaly 8, primary, autosomal recessive 10.3 CRP TF
32 adult malignant mesenchymoma 10.3 HP TF
33 acquired hemophilia 10.3 CRP HP
34 mediastinum leiomyoma 10.2 CRP TF
35 alcoholic liver cirrhosis 10.2 PRL TF
36 allergic bronchopulmonary aspergillosis 10.2 CRP IER3IP1
37 female breast upper-inner quadrant cancer 10.2 CRP HP
38 blind hypotensive eye 10.2 CRP TF
39 cataract 10.2 CRH TNF
40 brain glioblastoma multiforme 10.2 CRP IER3IP1
41 hereditary multiple exostoses 10.2 CRH CRP
42 ovarian clear cell malignant adenofibroma 10.1 CRP TF
43 halal setton wang syndrome 10.1 TF TNF
44 segmental odontomaxillary dysplasia 10.1 TF TNF
45 uterine corpus adenocarcinofibroma 10.1 CRH HP PRL
46 early-onset zonular cataract 10.1 TF TNF
47 chronic dacryoadenitis 10.1 CRH IER3IP1 PRL
48 usher syndrome, type 1f 10.1 CRH PRL
49 myositis fibrosa 10.1 CRH TNF
50 spondylolysis 10.1 PRL TNF

Graphical network of the top 20 diseases related to Melancholia:



Diseases related to Melancholia

Symptoms & Phenotypes for Melancholia

Drugs & Therapeutics for Melancholia

Drugs for Melancholia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nortriptyline Approved Phase 4 72-69-5 4543
2
Sertraline Approved Phase 4 79617-96-2 68617
3
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
4
Citalopram Approved Phase 4 59729-33-8 2771
5
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
6
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
7
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
8
Lamotrigine Approved, Investigational Phase 4,Phase 3 84057-84-1 3878
9 Adrenergic Agents Phase 4
10 Antidepressive Agents Phase 4,Phase 3,Phase 2
11 Antidepressive Agents, Tricyclic Phase 4
12 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
13 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
14 Psychotropic Drugs Phase 4,Phase 3,Phase 2
15
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
16 Serotonin Agents Phase 4,Phase 3,Phase 2
17 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 2
18 Antipsychotic Agents Phase 4,Phase 3
19 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
20 Quetiapine Fumarate Phase 4 111974-72-2
21 Tranquilizing Agents Phase 4,Phase 3,Phase 2
22 Desvenlafaxine Succinate Phase 4 386750-22-7
23 Duloxetine Hydrochloride Phase 4,Phase 3
24 Venlafaxine Hydrochloride Phase 4
25 Vilazodone Hydrochloride Phase 4 163521-08-2
26 Anticonvulsants Phase 4,Phase 3
27 calcium channel blockers Phase 4,Phase 3
28 Calcium, Dietary Phase 4,Phase 3
29 Diuretics, Potassium Sparing Phase 4,Phase 3
30 Excitatory Amino Acid Antagonists Phase 4,Phase 3
31 Excitatory Amino Acids Phase 4,Phase 3
32 Sodium Channel Blockers Phase 4,Phase 3
33
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
34
Norepinephrine Approved Phase 3 51-41-2 439260
35
Vortioxetine Approved Phase 3,Phase 2 508233-74-7 9966051
36
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
37
Ziprasidone Approved Phase 3 146939-27-7 60854
38 Analgesics Phase 3
39 Dopamine Agents Phase 3
40 Peripheral Nervous System Agents Phase 3
41 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
42 Anti-Anxiety Agents Phase 3,Phase 2
43 Serotonin 5-HT1 Receptor Agonists Phase 3,Phase 2
44 Serotonin 5-HT3 Receptor Antagonists Phase 3,Phase 2
45 Serotonin Antagonists Phase 3,Phase 2
46 Dopamine Antagonists Phase 3
47
Substance P Investigational Phase 2 33507-63-0 44359816
48 neurokinin A Phase 2
49
Epinephrine Approved, Vet_approved 51-43-4 5816
50 Racepinephrine Approved

Interventional clinical trials:

(show all 27)

id Name Status NCT ID Phase Drugs
1 Antidepressant Treatment of Melancholia in Late Life Completed NCT00000378 Phase 4 Sertraline;Nortriptyline
2 Quetiapine in Melancholic Depression Completed NCT01200901 Phase 4 Quetiapine
3 Effects of Treatment on Decision-making in Major Depression Completed NCT01916824 Phase 4 Any FDA Approved Antidepressant
4 Melancholic Depression and Insomnia as Predictors of Response to Quetiapine in Patients With Major Depression Active, not recruiting NCT03207438 Phase 4 Quetiapine 50 MG Extended Release Oral Tablet;Quetiapine Fumarate XR 150-300 mg;Placebos
5 Melancholic Symptoms in Bipolar Depression and Responsiveness to Lamotrigine Active, not recruiting NCT02989727 Phase 4 Lamotrigine;Placebos
6 Duloxetine in the Treatment of Melancholic Depression Completed NCT00191685 Phase 3 duloxetine
7 Depression And Bipolar Disorder Completed NCT00274677 Phase 3 Placebo;lamotrigine
8 Bipolar Disorder Study for Men and Women Completed NCT00056277 Phase 3 lamotrigine
9 Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder Completed NCT00072774 Phase 3 DVS-233 SR
10 Safety and Tolerability of Vortioxetine (LuAA21004) - Open Label Extension Study Completed NCT01152996 Phase 3 Vortioxetine
11 Efficacy and Safety Study of Vortioxetine (Lu AA21004) for Treatment of Major Depressive Disorder Completed NCT01255787 Phase 2, Phase 3 Vortioxetine;Placebo
12 Efficacy and Safety Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT01163266 Phase 3 Vortioxetine;Placebo
13 Safety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT01153009 Phase 3 Vortioxetine;Duloxetine;Placebo
14 A Study of the Effectiveness and Safety of Risperidone to Augment SSRI Therapy in Patients With Treatment-resistant Depression Completed NCT00044681 Phase 3 risperidone
15 Safety and Tolerability of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT00707980 Phase 3 Vortioxetine
16 Efficacy Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT00735709 Phase 3 Vortioxetine;Placebo
17 A Six-Week Flexible Dose Study Evaluating the Efficacy and Safety of Geodon in Patients With Bipolar I Depression. Completed NCT00282464 Phase 3 Placebo;Geodon (Ziprasidone)
18 A Six-Week Study Evaluating The Efficacy And Safety Of Geodon In Patients With A Diagnosis Of Bipolar I Depression Completed NCT00141271 Phase 3 Geodon (Ziprasidone);Geodon (Ziprasidone);Placebo
19 Serotonin Transporter Density in Late-life Depression With and Without Dementia Completed NCT01548937 Phase 2 I-123 ADAM
20 Safety and Efficacy Study in Patients With Major Depressive Disorder Completed NCT00896363 Phase 2 GSK163090 Tablets;GSK163090 Placebo Tablets
21 A Study Of The Efficacy And Safety Of CP-601,927 Augmentation Of Antidepressant Therapy In Major Depression Terminated NCT01098240 Phase 2 CP-601,927
22 A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed Dose Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder Terminated NCT00880399 Phase 2 orvepitant
23 A Randomised, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder Terminated NCT00880048 Phase 2 orvepitant
24 Effects of 3 Months of Selective Serotonin Reuptake Inhibitor (SSRI)-Treatment on Metabolism and Hypothalamic-pituitary-adrenal (HPA)-Axis in Young Men Born With Low Birth Weight Completed NCT00971815 Escitalopram;placebo
25 Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression Completed NCT00001479
26 Stepped Care aiTBS 2 Depression Study (Ghent) Recruiting NCT03288675 SSRI
27 Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions Terminated NCT01307475

Search NIH Clinical Center for Melancholia

Genetic Tests for Melancholia

Anatomical Context for Melancholia

MalaCards organs/tissues related to Melancholia:

39
Testes, Pituitary, Brain, Eye, Thyroid, Cortex, Prefrontal Cortex

Publications for Melancholia

Articles related to Melancholia:

(show top 50) (show all 366)
id Title Authors Year
1
Love and melancholia in the analysis of women by women. ( 28671276 )
2017
2
The genealogy of major depression: symptoms and signs of melancholia from 1880 to 1900. ( 28785109 )
2017
3
Defining melancholia: A core mood disorder. ( 28599349 )
2017
4
Are there differences in lipid peroxidation and immune biomarkers between major depression and bipolar disorder: Effects of melancholia, atypical depression, severity of illness, episode number, suicidal ideation and prior suicide attempts. ( 28867391 )
2017
5
Retrospective: Pursuing melancholia - The Australian contribution. ( 28030975 )
2017
6
To define melancholia, follow the path of catatonia. ( 28691306 )
2017
7
Social death, melancholia, and zombies: Same patterns? ( 28351493 )
2017
8
The properties and utility of the CORE measure of melancholia. ( 27721186 )
2017
9
The History of Melancholia Disease. ( 27840541 )
2016
10
Melancholia, Narcissism and Depression. ( 28638134 )
2016
11
Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression. ( 27259838 )
2016
12
THE SORROWS OF YOUNG WERTHER AND GOETHE'S UNDERSTANDING OF MELANCHOLIA. ( 26784722 )
2016
13
Anticipatory Reward Deficits in Melancholia. ( 27175986 )
2016
14
Melancholia, Narcissism and Depression. ( 27377400 )
2016
15
Associations of Serum Cytokine Receptor Levels with Melancholia, Staging of Illness, Depressive and Manic Phases, and Severity of Depression in Bipolar Disorder. ( 27660275 )
2016
16
The History of Melancholia Disease. ( 27516703 )
2016
17
Postpartum Psychosis: Madness, Mania, and Melancholia in Motherhood. ( 27609245 )
2016
18
Agoraphobia and Melancholia: Thoughts on Milrod's "Emptiness in Agoraphobia Patients". ( 26263925 )
2015
19
Melancholia. ( 26499302 )
2015
20
ON LOVE AND MELANCHOLIA IN MARGUERITE DURAS'S AUTOFICTION. ( 26198607 )
2015
21
Melancholia before the twentieth century: fear and sorrow or partial insanity? ( 25691879 )
2015
22
Scene unseen: Disrupted neuronal adaptation in melancholia during emotional film viewing. ( 26740919 )
2015
23
Inaccessible Masturbation, Impossible Mourning: Collective Melancholia, the Prohibition on Female Sexual Subjects in India, and Masturbation Fantasy as a Zone of the Strange. ( 26653059 )
2015
24
Disrupted effective connectivity of cortical systems supporting attention and interoception in melancholia. ( 25692565 )
2015
25
Melancholia Associated With Severe Cognitive Disorders as the Expression of Late-Onset Postpartum Anti-N-Methyl-d-Aspartic Acid Receptor Limbic Encephalitis. ( 25923872 )
2015
26
Melancholia and catatonia: disorders or specifiers? ( 25417594 )
2015
27
Melancholia in later life: late and early onset differences in presentation, course, and dementia risk. ( 24677247 )
2014
28
Antidepressant treatment of melancholia in older adults. ( 24119858 )
2014
29
Psychometric analysis of the Melancholia Scale in trials with non-pharmacological augmentation of patients with therapy-resistant depression. ( 25142191 )
2014
30
Right temporal activation differs between melancholia and nonmelancholic depression: a multichannel near-infrared spectroscopy study. ( 24780385 )
2014
31
Association between core-assigned melancholia and the melancholia subscale of the HAM-D. ( 25451414 )
2014
32
Microbiota, the immune system, black moods and the brain-melancholia updated. ( 25309394 )
2014
33
Brief, unidimensional melancholia rating scales are highly sensitive to the effect of citalopram and may have biological validity: implications for the research domain criteria (RDoC). ( 24836083 )
2014
34
Sifting through the sands of time: mourning and melancholia revisited via the documentary Nostalgia for the Light (2011). ( 24628289 )
2014
35
The impact of melancholia versus non-melancholia on resting-state, EEG alpha asymmetry: electrophysiological evidence for depression heterogeneity. ( 24467874 )
2014
36
Fewer study participants needed to demonstrate superior antidepressant efficacy when using the Hamilton melancholia subscale (HAM-D6) as outcome measure. ( 25487682 )
2014
37
Major depressive disorder with melancholia displays robust alterations in resting state heart rate and its variability: implications for future morbidity and mortality. ( 25505893 )
2014
38
Melancholia: definition and management. ( 24270479 )
2014
39
Melancholia in medieval Persian literature: The view of Hidayat of Al-Akhawayni. ( 25019055 )
2014
40
A case for reprising and redefining melancholia. ( 23547640 )
2013
41
Melancholia: past and present. ( 23547641 )
2013
42
Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias. ( 23639523 )
2013
43
Should psychomotor disturbance be an essential criterion for a DSM-5 diagnosis of melancholia? ( 23724792 )
2013
44
Validation of a new prototypic measure of melancholia. ( 23602392 )
2013
45
Loss of light in the eyes: a window to melancholia. ( 23751309 )
2013
46
The morbidity and mortality linked to melancholia: two cohorts compared, 1875-1924 and 1995-2005. ( 24572794 )
2013
47
Melancholia: a distinct entity? ( 23547639 )
2013
48
From Statistics to Diagnostics: Medical Certificates, Melancholia, and "Suicidal Propensities" in Victorian Psychiatry. ( 24293701 )
2013
49
Treating melancholia at home: theoretical wisdom and grim reality in the career of E.C. Seguin. ( 23628930 )
2013
50
Bringing back melancholia. ( 22329467 )
2012

Variations for Melancholia

Expression for Melancholia

Search GEO for disease gene expression data for Melancholia.

Pathways for Melancholia

Pathways related to Melancholia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.84 HP TNF
2 10.23 CRP TNF
3 9.58 PRL TNF

GO Terms for Melancholia

Cellular components related to Melancholia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CRH CRP HP TF TNF
2 extracellular region GO:0005576 9.1 CRH CRP HP PRL TF TNF

Biological processes related to Melancholia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.5 CRH CRP TNF
2 positive regulation of gene expression GO:0010628 9.43 CRH CRP TNF
3 positive regulation of cell death GO:0010942 9.16 CRH HP
4 acute-phase response GO:0006953 8.96 CRP HP
5 negative regulation of lipid storage GO:0010888 8.62 CRP TNF

Sources for Melancholia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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