MCID: MLN003
MIFTS: 46

Melancholia malady

Summaries for Melancholia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Melancholia (from Greek μελαγχολία melancholia \"sadness\", literally black bile), also... more...

MalaCards: Melancholia is related to endogenous depression and mood disorder. An important gene associated with Melancholia is AVPR1B (arginine vasopressin receptor 1B), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Development Leptin signaling via JAK/STAT and MAPK cascades. The compounds gnrh and hcrh have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and eye, and related mouse phenotypes are integument and endocrine/exocrine gland.

Aliases & Classifications for Melancholia

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

melancholia 8 10 60


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Disease Ontology8 DOID:2848
NCIt39 C34812
SNOMED-CT56 35489007
MeSH34 D003866

Related Diseases for Melancholia

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17GeneCards, 18GeneDecks
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Diseases related to Melancholia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1endogenous depression30.7CRH, SLC6A4
2mood disorder30.4CRH, TRH, POMC, MAOA, SLC6A4
3bipolar disorder30.2CRH, MAOA, SLC6A4
4addison's disease29.9POMC, CRH
5seasonal affective disorder29.9SLC6A4, CRH
6thyroiditis29.9TRH, POMC
7borderline personality disorder29.9SLC6A4, MAOA
8personality disorder29.9MAOA, SLC6A4
9dementia29.9TRH, MAOA, PLP1
10multiple sclerosis29.9TNF, POMC, PLP1
11schizophrenia29.8PRL, TRH, MAOA, PLP1, SLC6A4
12major depressive disorder10.3
13cerebritis10.2
14asthma10.1
15mental depression10.1
16parkinson's disease10.0MAOA
17cerebrovascular disease10.0TRH
18hyperthyroxinemia10.0TRH
19euthyroid sick syndrome10.0TRH
20exophthalmos10.0TRH
21leukodystrophy10.0PLP1
22cerebral palsy10.0PLP1
23prion disease10.0POMC
24serotonin syndrome10.0MAOA
25myasthenia gravis10.0PLP1
26adrenal carcinoma10.0POMC
27psoriatic arthritis10.0TNF
28myocardial infarction10.0SLC6A4
29acute myocardial infarction10.0SLC6A4
30ulcerative colitis10.0TNF
31sudden infant death syndrome10.0SLC6A4
32premature ejaculation10.0SLC6A4
33carney complex10.0POMC
34anovulation10.0PRL
35infertility10.0PRL
36pheochromocytoma10.0POMC, CRH
37adrenal adenoma10.0POMC, CRH
38substance dependence10.0SLC6A4
39fibromyalgia10.0SLC6A4, CRH
40substance abuse10.0SLC6A4, CRH
41hypokalemia10.0POMC
42gonadal disease10.0CRH, POMC
43cushing's syndrome10.0CRH, POMC
44irritable bowel syndrome10.0CRH, SLC6A4
45infantile epileptic encephalopathy10.0CRH, POMC
46bulimia nervosa10.0SLC6A4, MAOA
47obsessive-compulsive disorder10.0SLC6A4, MAOA
48hypoadrenalism10.0CRH, POMC
49severe pre-eclampsia10.0MAOA
50encephalomyelitis10.0PLP1, TNF

Graphical network of the top 20 diseases related to Melancholia:



Diseases related to melancholia

Clinical Features for Melancholia

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Drugs & Therapeutics for Melancholia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Melancholia

Search CenterWatch for Melancholia

Genetic Tests for Melancholia

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Anatomical Context for Melancholia

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32MalaCards
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MalaCards organs/tissues related to Melancholia:

32
Testes, Pituitary, Eye, Brain, Cortex, Thyroid, Prostate, Prefrontal cortex

Animal Models for Melancholia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Melancholia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.7SLC6A4, POMC, PRL, CRH, TNF
2MP:00053796.6TNF, CRH, PRL, TRH, POMC, AVPR1B
3MP:00053866.5TNF, CRH, PRL, POMC, MAOA, AVPR1B
4MP:00036316.1SLC6A4, TNF, CRH, PRL, TRH, POMC
5MP:00053766.1TNF, CRH, PRL, TRH, POMC, MAOA

Publications for Melancholia

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50PubMed
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Articles related to Melancholia:

(show top 50)    (show all 328)
idTitleAuthorsYear
1
High-dose tricyclics potentiation with mirtazapine, lithium and partial sleep-deprivation: why not tricyclics in combination strategies for resistant melancholia? (23983953)
2012
2
Melancholia in Janet Frame's Faces in the Water. (22870608)
2012
3
Validity of the definite and semidefinite questionnaire version of the Hamilton Depression Scale, the Hamilton Subscale and the Melancholia Scale. Part I. (20195869)
2011
4
Issues for DSM-5: whither melancholia? The case for its classification as a distinct mood disorder. (20595426)
2010
5
Measuring melancholia: the utility of a prototypic symptom approach. (18796174)
2009
6
Mother, melancholia, and humor in Erik H. Erikson's earliest writings. (19105029)
2008
7
Examining age effects on prototypic melancholic symptoms as a strategy for refining definition of melancholia. (18162189)
2008
8
Mother, melancholia, and dreams in Erik H. Erikson's Insight and Responsibility. (19105005)
2008
9
Melancholia agitata and mixed depression. (17280571)
2007
10
Melancholia: the importance of validity. (17415069)
2007
11
The stress response and the hypothalamic-pituitary-adrenal axis: from molecule to melancholia. (10873181)
2000
12
Antidepressant efficacy of Sudarshan Kriya Yoga (SKY) in melancholia: a randomized comparison with electroconvulsive therapy (ECT) and imipramine. (10708840)
2000
13
Increased remission rates with venlafaxine compared with fluoxetine in hospitalized patients with major depression and melancholia. (10836283)
2000
14
Double-blind comparison of citalopram and placebo in depressed outpatients with melancholia. (10207659)
1999
15
Melancholia and response to ECT. (7625490)
1995
16
Whose enlightenment? Medicine, witchcraft, melancholia and pathology. (7781281)
1995
17
Music and melancholia. (7853306)
1994
18
Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia. (7977878)
1994
19
Response to somatic treatment and placebo in patients with melancholia/endogenous depression. (8280275)
1993
20
Twice versus thrice weekly ECT in melancholia: a double-blind prospective comparison. (8509527)
1993
21
Paroxetine in the treatment of melancholia and severe depression. (1487627)
1992
22
Carbamazepine for treatment-resistant melancholia. (1744065)
1991
23
Predictors of antidepressant treatment outcome in melancholia: psychosocial, clinical and biological indicators. (1829739)
1991
24
Results of the 8 a.m. dexamethasone suppression test constitute a suitable tool for confirming the diagnosis of melancholia. A test unaffected by the variations in the bioavailability of dexamethasone. (2639285)
1989
25
Melancholia: from DSM-III to DSM-III-R. (2643354)
1989
26
The current age of youthful melancholia. Evidence for increase in depression among adolescents and young adults. (3167377)
1988
27
Enhanced binding of [3H] (-) adrenaline to platelets of depressed patients with melancholia: effect of long-term clomipramine treatment. (3031932)
1987
28
Development of melancholia during carbamazepine treatment in borderline personality disorder. (3525615)
1986
29
The "Melancholia Rating Scale": a useful instrument for the assessment of affective disorders. Validity and reliability of the Spanish adaptation. (3960972)
1986
30
Treatment responses in primary and secondary melancholia: a preliminary report. (4019421)
1985
31
6-Sulphatoxy melatonin in melancholia. (3966574)
1985
32
Attribution style, the dexamethasone suppression test, and the diagnosis of melancholia in depressed inpatients. (6512083)
1984
33
The clinical utility of family history for the diagnosis of melancholia. (6690653)
1984
34
Fluctuating postdexamethasone cortisol levels in a patient with melancholia. (7055259)
1982
35
Depression: a multivariate study of Sir Aubrey Lewis's data on melancholia. (336020)
1977
36
Melancholia, a model in madness: a discussion of recent psychobiologic research into depressive illness. (4591395)
1973
37
Changes in the treatment of involutional melancholia. (4891804)
1969
38
Mental hospital admissions for rural districts of England and Wales (1950-60) for all diagnoses, manic depressive reaction and involutional melancholia. (6072053)
1967
39
COMPARATIVE RESULTS OF THE TREATMENT OF MELANCHOLIA BY ELECTROSHOCK AND ANTIDEPRESSANT DRUGS. (14167687)
1964
40
The aetiology of involutional melancholia. (13916840)
1961
41
Iproniazid chemotherapy in melancholia. (13583240)
1958
42
Melancholia, glucose tolerance and body weight. (13564146)
1958
43
Changing Aspects of Melancholia. (20325447)
1957
44
Agitated melancholia. (14909907)
1952
45
Involutional melancholia. (14855111)
1951
46
Melancholia; clinical study of 50 selected cases. (15399769)
1950
47
On respiration in melancholia. (14770912)
1950
48
Personality adjustment following hospital treatment in patients with involutional psychosis, melancholia. (18911132)
1948
49
NOTES ON THE ANALYSIS OF A CASE OF MELANCHOLIA. (21611457)
1921
50
Artificial Feeding in Acute Melancholia. (20754634)
1894

Genetic Variations for Melancholia

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Expression for genes affiliated with Melancholia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Melancholia

Search GEO for disease gene expression data for Melancholia.

Pathways for genes affiliated with Melancholia

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49PharmGKB, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 53Reactome
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Pathways related to Melancholia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CRH, POMC
2
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.5POMC, TRH
39.1SLC6A4, TNF
4
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8.9MAOA, CRH, TNF
58.3SLC6A4, PLP1, MAOA, TNF
6
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8.2CRH, PRL, TRH, POMC, AVPR1B

Compounds for genes affiliated with Melancholia

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Melancholia according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1gnrh4410.3TRH
2hcrh449.8CRH, POMC
3pitressin449.7POMC, CRH
45-hydroxyindoleacetic acid44 2410.5MAOA, CRH, SLC6A4
5desmopressin44 59 28 1112.5AVPR1B, CRH, POMC
6alprazolam44 1110.5POMC, MAOA, CRH
7acth 1-24449.4PRL, CRH, POMC
8maoa449.4MAOA, POMC, SLC6A4
911 deoxycortisol449.4PRL, POMC, CRH
10hexarelin44 2810.4PRL, CRH, POMC
11citalopram49 44 11 2412.4PRL, MAOA, SLC6A4
12naltrexone44 49 28 1112.3POMC, PRL, CRH
13pyridostigmine44 1110.3PRL, TRH, CRH
14mdma449.3SLC6A4, PRL, MAOA
155-hydroxytryptophan449.3SLC6A4, PRL, CRH
16sulpiride44 28 1111.3TRH, PRL, CRH
1717-hydroxyprogesterone44 2410.3CRH, PRL, POMC
18sertraline44 28 49 11 2413.2POMC, CRH, SLC6A4, MAOA
19paroxetine44 49 28 1112.1MAOA, PRL, SLC6A4
20desipramine44 49 1111.1SLC6A4, MAOA, TRH, CRH
21mhpg449.1MAOA, CRH, PRL, SLC6A4
22dehydroepiandrosterone sulfate449.1CRH, POMC, PRL
23homovanillic acid44 2410.1SLC6A4, MAOA, PRL, CRH
24diazepam44 49 28 1112.1CRH, TRH, POMC
25clomipramine44 49 1111.0SLC6A4, MAOA, PRL, CRH
26fluoxetine49 44 28 1112.0PRL, MAOA, CRH, SLC6A4
27mirtazapine49 44 1111.0PRL, POMC, SLC6A4, CRH
28bromocriptine28 44 1110.9PRL, POMC, TRH
29naloxone44 49 28 1111.9PRL, POMC, CRH, TRH
30octreotide44 59 28 1111.9CRH, POMC, TRH, PRL
31opiate448.9PRL, SLC6A4, CRH, POMC
32amphetamine44 119.8POMC, MAOA, SLC6A4
33thyroxine44 249.8PRL, POMC, CRH, TRH
34clonidine44 28 1110.7PRL, TRH, POMC, SLC6A4
35haloperidol44 28 2 49 1112.7SLC6A4, POMC, TRH, PRL
36corticosterone44 59 2410.6CRH, SLC6A4, AVPR1B, POMC, PRL
37carbamazepine44 49 1110.6CRH, PRL, POMC, TNF
38acth448.6POMC, TRH, PRL, CRH, AVPR1B
395-hydroxytryptamine448.6POMC, PRL, CRH, MAOA, SLC6A4
40epinephrine44 11 2410.5PRL, POMC, MAOA, CRH, SLC6A4
41fenfluramine28 44 1110.5CRH, PRL, TRH, POMC, SLC6A4
42gaba448.3TRH, SLC6A4, PLP1, CRH, MAOA, POMC
43hydrocortisone44 2 59 1111.1POMC, CRH, PRL, TRH, TNF
44norepinephrine44 11 2410.1SLC6A4, MAOA, POMC, PRL, TRH, CRH
45dopamine44 28 11 2411.1TRH, CRH, PRL, SLC6A4, POMC, MAOA
46cocaine44 119.0TRH, POMC, PRL, CRH, SLC6A4, PLP1
47testosterone44 59 11 2411.0SLC6A4, CRH, PRL, TRH, POMC, MAOA
48estrogen447.9CRH, MAOA, PRL, TRH, POMC, SLC6A4
49arginine447.7PRL, SLC6A4, TRH, POMC, AVPR1B, PLP1
50dexamethasone44 49 28 1110.7POMC, CRH, TRH, TNF, MAOA, PRL

GO Terms for genes affiliated with Melancholia

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16Gene Ontology
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Cellular components related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.6POMC, TRH, PRL
2extracellular regionGO:0055767.7POMC, TRH, PRL, CRH, TNF

Biological processes related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to corticosterone stimulusGO:0514129.6TRH, CRH
2parturitionGO:0075679.5CRH, PRL
3positive regulation of gene expressionGO:0106289.1SLC6A4, PLP1, CRH
4response to ethanolGO:0454719.1TRH, PRL, CRH
5response to hypoxiaGO:0016668.3SLC6A4, TRH, TNF
6response to drugGO:0424938.3SLC6A4, PRL, CRH, TNF

Molecular functions related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6TRH, CRH
2hormone activityGO:0051798.8POMC, PRL, CRH

Products for genes affiliated with Melancholia

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Sources for Melancholia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet