MCID: MLN003
MIFTS: 46

Melancholia malady

Summaries for Melancholia

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Melancholia (from Greek μελαγχολία melancholia \"sadness\", literally black bile), also... more...

MalaCards: Melancholia is related to endogenous depression and mood disorder. An important gene associated with Melancholia is AVPR1B (arginine vasopressin receptor 1B), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Development Leptin signaling via JAK/STAT and MAPK cascades. The compounds gnrh and hcrh have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and eye, and related mouse phenotypes are integument and endocrine/exocrine gland.

Aliases & Classifications for Melancholia

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
See all sources

Aliases & Descriptions:

melancholia 8 10 60


External Ids:

Disease Ontology8 DOID:2848
NCIt39 C34812
SNOMED-CT56 35489007
MeSH34 D003866

Related Diseases for Melancholia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Melancholia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1endogenous depression30.7CRH, SLC6A4
2mood disorder30.4CRH, TRH, POMC, MAOA, SLC6A4
3bipolar disorder30.2CRH, MAOA, SLC6A4
4addison's disease29.9POMC, CRH
5seasonal affective disorder29.9SLC6A4, CRH
6thyroiditis29.9TRH, POMC
7borderline personality disorder29.9SLC6A4, MAOA
8personality disorder29.9MAOA, SLC6A4
9dementia29.9TRH, MAOA, PLP1
10multiple sclerosis29.9TNF, POMC, PLP1
11schizophrenia29.8PRL, TRH, MAOA, PLP1, SLC6A4
12major depressive disorder10.3
13cerebritis10.2
14asthma10.1
15mental depression10.1
16parkinson's disease10.0MAOA
17cerebrovascular disease10.0TRH
18hyperthyroxinemia10.0TRH
19euthyroid sick syndrome10.0TRH
20exophthalmos10.0TRH
21leukodystrophy10.0PLP1
22cerebral palsy10.0PLP1
23prion disease10.0POMC
24serotonin syndrome10.0MAOA
25myasthenia gravis10.0PLP1
26adrenal carcinoma10.0POMC
27psoriatic arthritis10.0TNF
28myocardial infarction10.0SLC6A4
29acute myocardial infarction10.0SLC6A4
30ulcerative colitis10.0TNF
31sudden infant death syndrome10.0SLC6A4
32premature ejaculation10.0SLC6A4
33carney complex10.0POMC
34anovulation10.0PRL
35infertility10.0PRL
36pheochromocytoma10.0POMC, CRH
37adrenal adenoma10.0POMC, CRH
38substance dependence10.0SLC6A4
39fibromyalgia10.0SLC6A4, CRH
40substance abuse10.0SLC6A4, CRH
41hypokalemia10.0POMC
42gonadal disease10.0CRH, POMC
43cushing's syndrome10.0CRH, POMC
44irritable bowel syndrome10.0CRH, SLC6A4
45infantile epileptic encephalopathy10.0CRH, POMC
46bulimia nervosa10.0SLC6A4, MAOA
47obsessive-compulsive disorder10.0SLC6A4, MAOA
48hypoadrenalism10.0CRH, POMC
49severe pre-eclampsia10.0MAOA
50encephalomyelitis10.0PLP1, TNF

Graphical network of the top 20 diseases related to Melancholia:



Diseases related to melancholia

Clinical Features for Melancholia

About this section

Drugs & Therapeutics for Melancholia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Melancholia

Drug clinical trials:

Search ClinicalTrials for Melancholia

Search NIH Clinical Center for Melancholia

Search CenterWatch for Melancholia

Genetic Tests for Melancholia

About this section

Anatomical Context for Melancholia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Melancholia:

32
Testes, Pituitary, Eye, Brain, Cortex, Thyroid, Prostate, Prefrontal cortex

Animal Models for Melancholia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Melancholia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.7SLC6A4, POMC, PRL, CRH, TNF
2MP:00053796.6TNF, CRH, PRL, TRH, POMC, AVPR1B
3MP:00053866.5TNF, CRH, PRL, POMC, MAOA, AVPR1B
4MP:00036316.1SLC6A4, TNF, CRH, PRL, TRH, POMC
5MP:00053766.1TNF, CRH, PRL, TRH, POMC, MAOA

Publications for Melancholia

About this section
Sources:
50PubMed
See all sources

Articles related to Melancholia:

(show top 50)    (show all 328)
idTitleAuthorsYear
1
Antidepressant treatment of melancholia in older adults. (24119858)
2014
2
Mapping melancholia: the continuing typological challenge for major depression. (21377737)
2012
3
Restoring melancholia in the classification of mood disorders. (17659352)
2008
4
Prospective relations between melancholia and substance use disorders. (18428068)
2008
5
Mourning and melancholia revisited: correspondences between principles of Freudian metapsychology and empirical findings in neuropsychiatry. (18652673)
2008
6
Electroconvulsive therapy in melancholia: the role of hippocampal neurogenesis. (17280579)
2007
7
The empirical status of melancholia: implications for psychology. (15596079)
2005
8
Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia. (15919819)
2005
9
Melancholia in the writing of a sixteenth-century Spanish nun. (15590577)
2004
10
Treatment of melancholia in Germany by acupuncture method for resuscitation. (15119164)
2004
11
Mourning beyond melancholia: Freud's psychoanalysis of loss. (15089015)
2004
12
Gender differences in severity, symptomatology and distribution of melancholia in major depression. (14504455)
2003
13
Variability in the serotonin transporter gene and increased risk for major depression with melancholia. (9799087)
1998
14
Melancholia with onset during treatment with SSRIs. (9988059)
1998
15
Sub-typing depression, III. Development of a clinical algorithm for melancholia and comparison with other diagnostic measures. (7480461)
1995
16
An augmented escape of androstenedione from suppression by dexamethasone in melancholia: relationships to intact ACTH and cortisol nonsuppression. (8550955)
1995
17
Increased limbic blood flow and total sleep deprivation in major depression with melancholia. (10711798)
1994
18
The loss of appetite during depression with melancholia: a qualitative and quantitative analysis. (8473722)
1993
19
Are there any differences between bipolar and unipolar melancholia? (1644992)
1992
20
Time estimation and the experience of time in endogenous depression (Melancholia): an experimental investigation. (2023986)
1991
21
Prediction of ECT Response in Melancholia. (11941106)
1991
22
Coexisting dysregulations of both the sympathoadrenal system and hypothalamic-pituitary-adrenal-axis in melancholia. (1930881)
1991
23
Respiratory depression and melancholia. (2086525)
1990
24
Historical melancholia. (2692770)
1989
25
Frequency of symptoms in melancholia (depressive illness) (2775946)
1989
26
Subtypes in major depression without melancholia. (3135603)
1988
27
Why not treat melancholia with melatonin and tryptophan and treat seasonal affective disorders with bright light? (3226357)
1988
28
Melancholia and depression during the 19th century: a conceptual history. (3074848)
1988
29
Cognitive dysfunction in melancholia. (3602228)
1987
30
Major depression with melancholia: a comparison of middle-aged and elderly adults. (3655175)
1987
31
ECT-induced EEG asymmetry and therapeutic response in melancholia: relation to treatment electrode placement. (3826432)
1987
32
Construct validity of the DSM-III and RDC classification of melancholia (endogenous depression). (3806424)
1986
33
Elevated plasma homovanillic acid in depressed females with melancholia and psychosis. (3859880)
1985
34
Comparative diagnostic criteria for melancholia and endogenous depression. (6721673)
1984
35
Neuroendocrine aspects of the relief of melancholia by induced seizures (electroconvulsive treatment). (6205561)
1984
36
Drug-responsive symptoms in melancholia. (6732425)
1984
37
Mourning distinct from melancholia: the resolution of bereavement. (6518144)
1984
38
The dexamethasone suppression test in depressed outpatients with and without melancholia. (6837794)
1983
39
The Melancholia Scale and the Newcastle Scales. Item-combinations and inter-observer reliability. (6882994)
1983
40
The importance of mood-incongruent psychotic symptoms in melancholia. (6222097)
1983
41
The dexamethasone suppression test for melancholia. (7093598)
1982
42
Mourning and the prevention of melancholia. (737142)
1978
43
Involutional melancholia. (5201790)
1970
44
Melancholia: diagnostic hints. (13863481)
1962
45
Investigations on the aetiology of involutional melancholia. (14430414)
1959
46
The relationship between glucose tolerance, body weight, and clinical state in melancholia. (13621152)
1958
47
Organic syndromes presenting as involutional melancholia. (13172515)
1954
48
Melancholia. (13063036)
1953
49
Involutional melancholia and convulsive therapy. (18135401)
1949
50
A Case of Melancholia, Associated with, and Perhaps Due to, Addison's Disease. (20744702)
1867

Genetic Variations for Melancholia

About this section

Expression for genes affiliated with Melancholia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Melancholia

Search GEO for disease gene expression data for Melancholia.

Pathways for genes affiliated with Melancholia

About this section
Sources:
49PharmGKB, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 53Reactome
See all sources

Pathways related to Melancholia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CRH, POMC
2
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
9.5POMC, TRH
39.1SLC6A4, TNF
4
Hide members
8.9MAOA, CRH, TNF
58.3SLC6A4, PLP1, MAOA, TNF
6
Hide members
8.2CRH, PRL, TRH, POMC, AVPR1B

Compounds for genes affiliated with Melancholia

About this section
Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Melancholia according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1gnrh4410.3TRH
2hcrh449.8CRH, POMC
3pitressin449.7POMC, CRH
45-hydroxyindoleacetic acid44 2410.5MAOA, CRH, SLC6A4
5desmopressin44 59 28 1112.5AVPR1B, CRH, POMC
6alprazolam44 1110.5POMC, MAOA, CRH
7acth 1-24449.4PRL, CRH, POMC
8maoa449.4MAOA, POMC, SLC6A4
911 deoxycortisol449.4PRL, POMC, CRH
10hexarelin44 2810.4PRL, CRH, POMC
11citalopram49 44 11 2412.4PRL, MAOA, SLC6A4
12naltrexone44 49 28 1112.3POMC, PRL, CRH
13pyridostigmine44 1110.3PRL, TRH, CRH
14mdma449.3SLC6A4, PRL, MAOA
155-hydroxytryptophan449.3SLC6A4, PRL, CRH
16sulpiride44 28 1111.3TRH, PRL, CRH
1717-hydroxyprogesterone44 2410.3CRH, PRL, POMC
18sertraline44 28 49 11 2413.2POMC, CRH, SLC6A4, MAOA
19paroxetine44 49 28 1112.1MAOA, PRL, SLC6A4
20desipramine44 49 1111.1SLC6A4, MAOA, TRH, CRH
21mhpg449.1MAOA, CRH, PRL, SLC6A4
22dehydroepiandrosterone sulfate449.1CRH, POMC, PRL
23homovanillic acid44 2410.1SLC6A4, MAOA, PRL, CRH
24diazepam44 49 28 1112.1CRH, TRH, POMC
25clomipramine44 49 1111.0SLC6A4, MAOA, PRL, CRH
26fluoxetine49 44 28 1112.0PRL, MAOA, CRH, SLC6A4
27mirtazapine49 44 1111.0PRL, POMC, SLC6A4, CRH
28bromocriptine28 44 1110.9PRL, POMC, TRH
29naloxone44 49 28 1111.9PRL, POMC, CRH, TRH
30octreotide44 59 28 1111.9CRH, POMC, TRH, PRL
31opiate448.9PRL, SLC6A4, CRH, POMC
32amphetamine44 119.8POMC, MAOA, SLC6A4
33thyroxine44 249.8PRL, POMC, CRH, TRH
34clonidine44 28 1110.7PRL, TRH, POMC, SLC6A4
35haloperidol44 28 2 49 1112.7SLC6A4, POMC, TRH, PRL
36corticosterone44 59 2410.6CRH, SLC6A4, AVPR1B, POMC, PRL
37carbamazepine44 49 1110.6CRH, PRL, POMC, TNF
38acth448.6POMC, TRH, PRL, CRH, AVPR1B
395-hydroxytryptamine448.6POMC, PRL, CRH, MAOA, SLC6A4
40epinephrine44 11 2410.5PRL, POMC, MAOA, CRH, SLC6A4
41fenfluramine28 44 1110.5CRH, PRL, TRH, POMC, SLC6A4
42gaba448.3TRH, SLC6A4, PLP1, CRH, MAOA, POMC
43hydrocortisone44 2 59 1111.1POMC, CRH, PRL, TRH, TNF
44norepinephrine44 11 2410.1SLC6A4, MAOA, POMC, PRL, TRH, CRH
45dopamine44 28 11 2411.1TRH, CRH, PRL, SLC6A4, POMC, MAOA
46cocaine44 119.0TRH, POMC, PRL, CRH, SLC6A4, PLP1
47testosterone44 59 11 2411.0SLC6A4, CRH, PRL, TRH, POMC, MAOA
48estrogen447.9CRH, MAOA, PRL, TRH, POMC, SLC6A4
49arginine447.7PRL, SLC6A4, TRH, POMC, AVPR1B, PLP1
50dexamethasone44 49 28 1110.7POMC, CRH, TRH, TNF, MAOA, PRL

GO Terms for genes affiliated with Melancholia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.6POMC, TRH, PRL
2extracellular regionGO:0055767.7POMC, TRH, PRL, CRH, TNF

Biological processes related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to corticosterone stimulusGO:0514129.6TRH, CRH
2parturitionGO:0075679.5CRH, PRL
3positive regulation of gene expressionGO:0106289.1SLC6A4, PLP1, CRH
4response to ethanolGO:0454719.1TRH, PRL, CRH
5response to hypoxiaGO:0016668.3SLC6A4, TRH, TNF
6response to drugGO:0424938.3SLC6A4, PRL, CRH, TNF

Molecular functions related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6TRH, CRH
2hormone activityGO:0051798.8POMC, PRL, CRH

Products for genes affiliated with Melancholia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Melancholia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet