MCID: MLN003
MIFTS: 48

Melancholia malady

Mental diseases category
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Summaries for Melancholia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Melancholia (from Greek ?????????? melancholia \"sadness\", literally black bile), also lugubriousness,... more...

MalaCards: Melancholia is related to endogenous depression and mood disorder. An important gene associated with Melancholia is AVPR1B (arginine vasopressin receptor 1B), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Cytochrome P450 - arranged by substrate type. The compounds pitressin and acth 1-24 have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and brain, and related mouse phenotypes are growth/size/body and integument.

Aliases & Classifications for Melancholia

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8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

melancholia 8 10 62


External Ids:

Disease Ontology8 DOID:2848
NCIt40 C34812
SNOMED-CT58 35489007
MeSH35 D003866

Related Diseases for Melancholia

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17GeneCards, 18GeneDecks
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Diseases related to Melancholia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1endogenous depression30.8SLC6A4, CRH
2mood disorder30.3POMC, MAOA, CRH, SLC6A4, TRH
3thyroiditis30.1POMC, TRH
4addison's disease30.0CRH, POMC
5seasonal affective disorder30.0SLC6A4, CRH
6personality disorder30.0MAOA, SLC6A4
7borderline personality disorder30.0MAOA, SLC6A4
8bipolar disorder30.0SLC6A4, CRH, MAOA
9schizophrenia29.9PRL, MAOA, SLC6A4, TRH
10blindness10.4
11major depressive disorder10.3
12cerebritis10.2
13asthma10.1
14exophthalmos10.1TRH
15euthyroid sick syndrome10.1TRH
16hyperthyroxinemia10.1TRH
17serotonin syndrome10.1MAOA
18adrenal carcinoma10.1POMC
19skin disease10.1POMC
20premature ejaculation10.1SLC6A4
21pervasive developmental disorder10.1SLC6A4
22asperger syndrome10.1SLC6A4
23gonadal disease10.1POMC, CRH
24cushing's syndrome10.1POMC, CRH
25hypoadrenalism10.1POMC, CRH
26infantile epileptic encephalopathy10.1POMC, CRH
27hypothalamic disease10.0PRL, CRH
28congenital adrenal hyperplasia10.0CRH, POMC
29pituitary carcinoma10.0PRL, POMC
30neurogenic diabetes insipidus10.0POMC, PRL
31thyrotropin deficiency, isolated10.0POMC, PRL
32panhypopituitarism10.0POMC, PRL
33substance abuse10.0CRH, SLC6A4
34klinefelter's syndrome10.0PRL, TRH
35adrenocortical carcinoma10.0CRH, POMC
36antisocial personality disorder10.0MAOA, SLC6A4
37vitiligo10.0MAOA, POMC
38precocious puberty10.0POMC, PRL
39adrenal adenoma10.0CRH, POMC
40social phobia10.0MAOA, SLC6A4
41primary hyperoxaluria10.0POMC, CRH, TRH
42fibromyalgia10.0CRH, SLC6A4
43pain agnosia10.0POMC, CRH
44drug dependence10.0MAOA, SLC6A4
45generalized anxiety disorder10.0MAOA, SLC6A4
46conduct disorder10.0MAOA, SLC6A4
47bulimia nervosa10.0MAOA, SLC6A4
48gilles de la tourette syndrome10.0MAOA, SLC6A4
49irritable bowel syndrome10.0CRH, SLC6A4
50obsessive-compulsive disorder10.0MAOA, SLC6A4

Graphical network of the top 20 diseases related to Melancholia:



Diseases related to melancholia

Symptoms for Melancholia

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Drugs & Therapeutics for Melancholia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Melancholia

Search NIH Clinical Center for Melancholia

Genetic Tests for Melancholia

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Anatomical Context for Melancholia

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33MalaCards
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MalaCards organs/tissues related to Melancholia:

33
Testes, Pituitary, Brain, Eye, Thyroid, Cortex, Prefrontal cortex

Animal Models for Melancholia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Melancholia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.7TRH, SLC6A4, CRH, POMC, TNF
2MP:00107717.4TNF, POMC, PRL, CRH, SLC6A4
3MP:00053796.9AVPR1B, TNF, POMC, PRL, CRH, SLC6A4
4MP:00053866.8AVPR1B, TNF, POMC, PRL, MAOA, CRH
5MP:00036316.5TRH, AVPR1B, TNF, POMC, PRL, MAOA
6MP:00053766.4AVPR1B, TNF, POMC, PRL, MAOA, CRH

Publications for Melancholia

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Sources:
52PubMed
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Articles related to Melancholia:

(show top 50)    (show all 321)
idTitleAuthorsYear
1
Melancholia: past and present. (23547641)
2013
2
The interdependence of subtype and severity: contributions of clinical and neuropsychological features to melancholia and non-melancholia in an outpatient sample. (22300644)
2012
3
Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression. (21945535)
2012
4
Electroconvulsive therapy and melancholia: review of the literature and suggestions for further study. (21673591)
2011
5
The incidence and prevalence of admissions for melancholia in two cohorts (1875-1924 and 1995-2005). (21733576)
2011
6
Issues for DSM-5: whither melancholia? The case for its classification as a distinct mood disorder. (20595426)
2010
7
Mother, melancholia, and humor in Erik H. Erikson's earliest writings. (19105029)
2008
8
A mixed state core for melancholia: an exploration in history, art and clinical science. (17280570)
2007
9
Resurrecting melancholia. (17280566)
2007
10
In search of Aristotle: temperament, human nature, melancholia, creativity and eminence. (17499855)
2007
11
As a prelude: bringing melancholia to book. (16878733)
2006
12
Black bile and psychomotor retardation: shades of melancholia in Dante's Inferno. (15370340)
2004
13
Functional but not structural subgenual prefrontal cortex abnormalities in melancholia. (14699431)
2004
14
The prolactin response to fenfluramine in depression: effects of melancholia and baseline cortisol. (12680745)
2003
15
The stress response and the hypothalamic-pituitary-adrenal axis: from molecule to melancholia. (10873181)
2000
16
TCM treatment with the modified wendan tang in 40 cases of melancholia. (10921137)
1999
17
Once vs. three times weekly ECT in melancholia: a randomized controlled trial. (9821454)
1998
18
Variability in the serotonin transporter gene and increased risk for major depression with melancholia. (9799087)
1998
19
Sub-typing depression, III. Development of a clinical algorithm for melancholia and comparison with other diagnostic measures. (7480461)
1995
20
Music and melancholia. (7853306)
1994
21
A double-blind comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia. The Venlafaxine French Inpatient Study Group. (7814822)
1994
22
A modern melancholia: Van Gogh's portrait of Dr Gachet. (8234566)
1993
23
Response to somatic treatment and placebo in patients with melancholia/endogenous depression. (8280275)
1993
24
The anatomy of melancholia--focal abnormalities of cerebral blood flow in major depression. (1410086)
1992
25
Time experience in melancholia: a comparison between findings based on phenomenology and experimental psychology. (1935022)
1991
26
Time estimation and the experience of time in endogenous depression (Melancholia): an experimental investigation. (2023986)
1991
27
Prediction of ECT Response in Melancholia. (11941106)
1991
28
Factor study of the Hamilton Rating Scale for Depression and the Bech Melancholia Scale. (2239363)
1990
29
Corticotropin, cortisol and beta-endorphin responses to the human corticotropin-releasing hormone during melancholia and after unilateral electroconvulsive therapy. (2174200)
1990
30
Results of the 8 a.m. dexamethasone suppression test constitute a suitable tool for confirming the diagnosis of melancholia. A test unaffected by the variations in the bioavailability of dexamethasone. (2639285)
1989
31
The current age of youthful melancholia. Evidence for increase in depression among adolescents and young adults. (3167377)
1988
32
Relationships of the dexamethasone suppression test to clinical severity and degree of melancholia. (3697434)
1986
33
Hypochondriacal fears and beliefs in DSM-III melancholia. Changes with amitriptyline. (2939120)
1986
34
DSM-III melancholia: do the criteria accurately and reliably distinguish endogenous pattern depression? (2943772)
1986
35
The tyramine challenge test as a marker for melancholia. (6732426)
1984
36
Attribution style, the dexamethasone suppression test, and the diagnosis of melancholia in depressed inpatients. (6512083)
1984
37
Comparative diagnostic criteria for melancholia and endogenous depression. (6721673)
1984
38
Dexamethasone suppression tests in antidepressant treatment of melancholia. The process of normalization and test-retest reproducibility. (6340634)
1983
39
The "myth' of involutional melancholia. (7043302)
1982
40
Fluctuating postdexamethasone cortisol levels in a patient with melancholia. (7055259)
1982
41
Depression: a multivariate study of Sir Aubrey Lewis's data on melancholia. (336020)
1977
42
Mental hospital admissions in England and Wales 1950-60 for all diagnoses, manic depressive reaction and involutional melancholia. (6072175)
1967
43
Melancholia: diagnostic hints. (13863481)
1962
44
Investigations on the aetiology of involutional melancholia. (14430414)
1959
45
Iproniazid chemotherapy in melancholia. (13583240)
1958
46
Involutional melancholia and depressive states: results of treatment over a 5-year period. (14888627)
1951
47
Involutional melancholia and convulsive therapy. (18135401)
1949
48
Personality adjustment following hospital treatment in patients with involutional psychosis, melancholia. (18911132)
1948
49
The prognosis and treatment of melancholia. (20287236)
1947
50
A Case of Melancholia, Associated with, and Perhaps Due to, Addison's Disease. (20744702)
1867

Variations for Melancholia

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Expression for genes affiliated with Melancholia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Melancholia

Search GEO for disease gene expression data for Melancholia.

Pathways for genes affiliated with Melancholia

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Sources:
50PathCards, 51PharmGKB, 55Reactome, 38NCBI BioSystems Database, 60Thomson Reuters, 30KEGG
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Pathways related to Melancholia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CRH, POMC
2
Show member pathways
9.6MAOA, POMC
39.5PRL, POMC
4
Show member pathways
9.5POMC, TRH
59.4MAOA, SLC6A4
69.2POMC, TNF
78.6TNF, MAOA, SLC6A4
8
Show member pathways
Serotonin Transporter Activity38
8.6SLC6A4, MAOA, TNF
9
Show member pathways
8.3CRH, MAOA, PRL, TNF
10
Show member pathways
8.3TRH, CRH, PRL, POMC, AVPR1B
11
Show member pathways
8.3AVPR1B, POMC, PRL, CRH, TRH

Compounds for genes affiliated with Melancholia

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Melancholia according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1pitressin459.6POMC, CRH
2acth 1-24459.5CRH, PRL, POMC
311 deoxycortisol459.5PRL, CRH, POMC
4hexarelin45 2910.5POMC, PRL, CRH
5desmopressin45 61 29 1112.4CRH, POMC, AVPR1B
6alprazolam45 1110.4CRH, MAOA, POMC
7naltrexone45 29 51 1112.4POMC, PRL, CRH
8pyridostigmine45 1110.4TRH, CRH, PRL
9sulpiride45 29 1111.4TRH, CRH, PRL
10hcrh459.3CRH, POMC
1117-hydroxyprogesterone45 2410.3PRL, POMC, CRH
125-hydroxyindoleacetic acid45 2410.3SLC6A4, CRH, MAOA
135-hydroxytryptophan459.3CRH, PRL, SLC6A4
14mdma459.3PRL, MAOA, SLC6A4
15maoa459.3SLC6A4, MAOA, POMC
16dehydroepiandrosterone sulfate459.2PRL, POMC, CRH
17diazepam45 29 51 1112.1TRH, CRH, POMC
18paroxetine45 51 29 1112.1SLC6A4, MAOA, PRL
19bromocriptine45 29 1111.1PRL, TRH, POMC
20sertraline45 29 51 24 1113.1SLC6A4, CRH, MAOA, POMC
21naloxone45 29 51 1112.0CRH, TRH, POMC, PRL
22mhpg459.0CRH, MAOA, SLC6A4, PRL
23homovanillic acid45 2410.0CRH, MAOA, PRL, SLC6A4
24clomipramine45 51 1111.0SLC6A4, PRL, MAOA, CRH
25octreotide45 61 29 1112.0CRH, POMC, PRL, TRH
26desipramine45 51 1111.0CRH, TRH, SLC6A4, MAOA
27fluoxetine45 51 29 1112.0SLC6A4, CRH, MAOA, PRL
28citalopram45 51 24 1111.9CRH, PRL, SLC6A4, MAOA
29mirtazapine45 51 1110.9SLC6A4, CRH, PRL, POMC
30amphetamine45 51 1110.9SLC6A4, MAOA, POMC
31opiate458.9PRL, SLC6A4, POMC, CRH
32thyroxine45 249.8TRH, CRH, POMC, PRL
33clonidine45 51 29 1111.7TRH, POMC, PRL, SLC6A4
34haloperidol45 51 29 3 1112.7TRH, POMC, PRL, SLC6A4
35carbamazepine45 51 1110.7POMC, PRL, CRH, TNF
36acth458.7POMC, TRH, CRH, PRL, AVPR1B
37corticosterone45 61 2410.6SLC6A4, CRH, PRL, POMC, AVPR1B
385-hydroxytryptamine458.5POMC, MAOA, PRL, CRH, SLC6A4
39gaba458.5POMC, MAOA, CRH, SLC6A4, TRH
40epinephrine45 24 1110.5PRL, MAOA, SLC6A4, CRH, POMC
41fenfluramine45 29 1110.4TRH, CRH, POMC, PRL, SLC6A4
42cocaine45 119.4PRL, CRH, SLC6A4, TRH, POMC
43gnrh458.4POMC, PRL, CRH, SLC6A4, TRH
44hydrocortisone45 3 61 1111.2TNF, TRH, CRH, PRL, POMC
45norepinephrine45 24 1110.0TRH, MAOA, SLC6A4, POMC, CRH, PRL
46dopamine45 29 24 1111.0POMC, TRH, SLC6A4, CRH, MAOA, PRL
47arginine458.0AVPR1B, PRL, CRH, SLC6A4, TRH, POMC
48testosterone45 61 24 1111.0SLC6A4, POMC, PRL, TRH, CRH, MAOA
49estrogen457.9TRH, POMC, SLC6A4, CRH, MAOA, PRL
50dexamethasone45 51 29 1110.7TNF, POMC, PRL, MAOA, CRH, TRH

GO Terms for genes affiliated with Melancholia

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16Gene Ontology
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Cellular components related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.5TRH, POMC
2extracellular regionGO:0055768.8TRH, CRH, POMC

Biological processes related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to corticosteroneGO:0514129.6TRH, CRH
2response to ethanolGO:0454719.6TRH, CRH
3female pregnancyGO:0075659.3CRH, PRL
4negative regulation of gene expressionGO:0106299.2CRH, TNF
5response to drugGO:0424938.7TNF, CRH, SLC6A4
6response to hypoxiaGO:0016668.6TRH, SLC6A4, TNF

Molecular functions related to Melancholia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6TRH, CRH
2hormone activityGO:0051798.8CRH, PRL, POMC

Products for genes affiliated with Melancholia

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Sources for Melancholia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet