Search MalaCards:
MCID: MLN008

Melanoma malady
25 drugs, 2079 genes, 32 tissues, 891 related diseases, 29 phenotypes, 6460 articles, clinical trials.

Summaries for Melanoma

about this section
Sources:
6Disease Ontology, 23MedlinePlus, 44Wikipedia, 33OMIM, 22MalaCards
See all sources

Export this MalaCard
MedlinePlus: Melanoma is the most serious type of skin cancer. often the first sign of melanoma is a change in the size, shape, color or feel of a mole. most melanomas have a black or black-blue area. melanoma may also appear as a new mole. it may be black, abnormal or "ugly looking." thinking of "abcd" can help you remember what to watch for: asymmetry - the shape of one half does not match the other border - the edges are ragged, blurred or irregular color - the color is uneven and may include shades of black, brown and tan diameter - there is a change in size, usually an increase melanoma can be cured if it is diagnosed and treated early. if melanoma is not removed in its early stages, cancer cells may grow downward from the skin surface and invade healthy tissue. if it spreads to other parts of the body it can be difficult to control.23

MalaCards: Melanoma, also known as malignant melanoma, is related to carcinoma and prostatitis. An important gene associated with Melanoma is CSPG4 (chondroitin sulfate proteoglycan 4), and among its related pathways are Antioxidant Action of Vitamin-C and Estrogen Pathway. The drugs interferon alfa 2-b and interferon alfacon-1 and the compounds cholesterol and paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are cardiovascular system and immune system.

Disease Ontology: A cell type cancer that has material basis in abnormally proliferating cells derived from melanocytes which are found in skin, the bowel and the eye.6

Wikipedia: Melanoma i/ˌmɛləˈnoʊmə/ (from Greek μέλας — melas, \"dark\") is a malignant tumor of...44 more...

OMIM: 609048

Aliases & Descriptions for Melanoma

about this section
Sources:
6Disease Ontology, 7diseasecard, 8DISEASES, 33OMIM, 32Novoseek , 23MedlinePlus, 43UMLS, 40SNOMED-CT, 27NCIt, 24MeSH
See all sources

Aliases & Descriptions:

melanoma 6 7 8 33 32 23 43
malignant melanoma 6 7
malignant melanoma, morphology (morphologic abnormality) 6
malignant melanoma nos (morphologic abnormality) 6
malignant melanoma (disorder) 6
cutaneous melanoma 43
naevocarcinoma 6

Related Diseases for Melanoma

about this section
Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to melanoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 888)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma378.2PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
2prostatitis300.1PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
3leukemia294.7PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
4neuronitis265.7PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5pancreatitis263.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
6adenocarcinoma249.6PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRAT
7hepatocellular carcinoma241.3PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, KL
8colorectal cancer239.0PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
9thyroiditis228.6PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
10gastric cancer219.9PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF5, KLF6
11breast carcinoma201.2PIK3CA, PIK3R1, PIK3CG, PI3, LRP1, NCEH1
12arthritis199.8PIK3CD, PIK3CG, LRP1, KL, KLF5, PDCD1
13colon cancer199.5PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, KLF5
14cervicitis198.3PIK3CA, PIK3CG, KL, NCL, PDCD1, PDCD1LG2
15neuroblastoma194.6PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRP1
16sarcoma193.3PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
17esophagitis188.1PIK3CB, PIK3CA, PIK3C2A, PIK3CG, KLF5, KLF6
18rheumatoid arthritis187.5PIK3CD, PIK3CG, LRP1, KL, KLF5, PDCD1
19hypoxia187.1PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
20myeloid leukemia172.1PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
21fibrosis161.6PIK3CA, PIK3CG, PI3, LRP1, KL, KLF6
22retinitis160.4PIK3CA, PIK3C2A, PIK3CG, LRAT, LRP1, KLF6
23ovarian carcinoma156.8PIK3CA, PIK3CG, PI3, NDN, NCOA3, RECK
24lung carcinoma150.3PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
25cerebritis147.0PIK3R1, PIK3C2A, PIK3CG, LRP1, KLF6, NCAM1
26colon carcinoma145.1PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, KL
27cholesterol142.9PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
28cervical cancer142.5PIK3CA, PIK3CG, NCL, PDCD1, RELA, VTN
29astrocytoma138.4PIK3CA, PIK3R1, PIK3CG, LRP1, KLF6, NCAM1
30osteosarcoma138.2PIK3CB, PIK3CA, PIK3CG, PDE1C, PDE3A, PDE3B
31tuberculosis128.4PIK3CG, NCEH1, PDCD1, PDCD1LG2, PDE3B, RELA
32acute myeloid leukemia128.3PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
33oral squamous cell carcinoma126.6PIK3CA, PIK3C2A, PDCD1, PDCD1LG2, RECK, VTN
34nasopharyngitis121.6PIK3CA, PIK3CG, KLF5, KLF6, NCAPG, NCOA3
35malaria121.6PIGG, LRP1, RFC5, NCL, PDE1C, PDE3A
36retinoblastoma121.4PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLF6
37gonococcal synovitis118.9PIK3CB, PIK3CA, PIK3R1, PIK3CG, PI3, LRP1
38peritonitis115.5PIK3C2A, LRP1, PDE3B, RELA, RELB, RET
39psoriasis113.8PI3, LRP1, PDE4A, KIR3DL2, KIR2DL1, KIR2DL3
40endometrial cancer110.0PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
41thyroid carcinoma108.0PIK3CA, PIK3CG, PI3, RET, KIR3DL2, KITLG
42anemia108.0NCAM1, PDCD1, RELA, KIT, KITLG, VWF
43myeloma106.7PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, NCAM1
44malignant glioma106.5PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
45alzheimer's disease103.9PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRAT
46influenza103.0PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
47renal cell carcinoma100.6PIK3CA, PDCD1, RELA, RET, KIT, KISS1
48thyroid cancer100.6PIK3CA, PIK3R1, PIK3CG, NCOA3, RET, KIT
49cholangiocarcinoma97.0PIK3CA, PIK3CG, NCAM1, RECK, KIT, SFN
50adenoma96.0PIK3CA, NCAM1, NCOA2, NCOA3, PDE4A, RECK

Graphical network of the top 20 diseases related to melanoma:



Graphical network of diseases related to melanoma

Clinical Features for Melanoma

about this section
Sources:
33OMIM
See all sources
Clinical features from OMIM: 609048

Drugs & Therapeutics for Melanoma

about this section
Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for melanoma

Drug clinical trials:

Search ClinicalTrials for melanoma

Search NIH Clinical Center for melanoma

Search CenterWatch for melanoma

Inferred drug relations via UMLS/NDF-RT:

43 28 aldesleukin, bleomycin, bleomycin sulfate, carmustine, dacarbazine, dactinomycin, docetaxel, hydroxyurea, interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, lomustine, peginterferon alfa-2a, peginterferon alfa-2b, procarbazine, procarbazine hydrochloride, temozolomide

Genetic Tests for Melanoma

about this section

Anatomical Context for Melanoma

about this section
Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to melanoma:

22
Bone marrow, Whole blood, Lymph node, Spleen, Brain, Retina, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Breast, Skin, Ovary, Placenta, Prostate, Testis, Cervix, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid, Pineal, Testis germ

Phenotypes for genes affiliated with Melanoma

about this section
Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to melanoma:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1cardiovascular system phenotypeMP:000538599.3PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
2immune system phenotypeMP:000538789.1PIK3CD, PIK3R5, LRP1, KL, KLF5, NCEH1
3hematopoietic system phenotypeMP:000539772.6KLF6, PDCD1, PDCD1LG2, CNTF, KIT, KISS1R
4integument phenotypeMP:001077170.0PIK3CG, KL, KLF6, NDN, NCOA2, NCOA3
5vision/eye phenotypeMP:000539168.0PIK3CA, LRAT, NCAM1, PDCD1, RELA, KIT
6tumorigenesisMP:000200666.2PIK3CB, PIK3CA, PIK3R2, PIK3R1, NCOA3, PDCD1LG2
7normal phenotypeMP:000287365.5PIK3R1, LRP1, KLF5, NDN, NCK1, NCK2
8muscle phenotypeMP:000536961.6PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, KL
9skeleton phenotypeMP:000539059.6PIK3CD, PIK3CG, LRP1, RECK, REL, RELA
10embryogenesis phenotypeMP:000538058.3PIK3CB, PIK3CA, PIR, KLF5, KLF6, NCK1
11digestive/alimentary phenotypeMP:000538156.4KL, KLF5, NCOA3, REL, RELB, RET
12renal/urinary system phenotypeMP:000536744.4KL, NCK1, NCK2, NCOA3, PDCD1, RET
13limbs/digits/tail phenotypeMP:000537141.8KL, RECK, RELA, RELB, RET, KIT
14no phenotypic analysisMP:000301239.8PIK3CD, PIK3R1, NDN, NCOA2, PDCD1LG2, RET
15craniofacial phenotypeMP:000538235.7NCOA3, KIT, KITLG, RBL1, NBN, LPAR1
16hearing/vestibular/ear phenotypeMP:000537734.5NCOA3, KIT, KITLG, SFN, RB1, RBP1
17adipose tissue phenotypeMP:000537532.5PIK3CA, PIK3R1, PIK3C2A, LRP1, KL, NCOA3
18respiratory system phenotypeMP:000538829.8KL, KLF5, NDN, REL, RELB, RET
19pigmentation phenotypeMP:000118628.2PDE3B, KIT, KITLG, RB1, RBP1, SERPINF1
20other phenotypeMP:000539521.8KL, KLC1, RECK, RELB, BUB1, RARA
21liver/biliary system phenotypeMP:0005370INFKLF6, NCOA3, RECK, REL, RELB, KIT
22reproductive system phenotypeMP:0005389INFPIK3CA, LRAT, KLF6, NCOA2, NCOA3, PDE3A
23cellular phenotypeMP:0005384INFPIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3R5, PIK3CG
24mortality/agingMP:0010768INFPIK3CB, PIK3CA, PIK3C2A, LRP1, KL, KLF5
25growth/size phenotypeMP:0005378INFPIK3CB, PIK3CA, PIK3R1, PIR, PIK3C2A, PIK3CG
26nervous system phenotypeMP:0003631INFLRAT, LRP1, KL, KLC1, NDN, NCK1
27behavior/neurological phenotypeMP:0005386INFPIK3CA, LRP1, KL, KLC1, NDN, NCAM1
28endocrine/exocrine gland phenotypeMP:0005379INFKL, KLF5, NCOA2, RELB, RET, KISS1
29homeostasis/metabolism phenotypeMP:0005376INFPIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A

Publications for genes affiliated with Melanoma

about this section
Sources:
35PubMed
See all sources

Articles related to melanoma:

(show top 50)    (show all 6460)
idTitleAuthorsYearAffiliating Genes
1FoxP3 expression on melanoma cells is related to earl y visceral spreading in melanoma patients treated by electrochemotherapy. (21696572)Quaglino P.... Bernengo M.G.2011FOXP3
2Changes in oligosaccharide chains of autoantibodies t o GRP78 expressed during progression of malignant melanoma stimulate melanoma c ell growth and survival. (21597391)Selim M.A.... Gonzalez-Gronow M.2011HSPA5
3Ultraviolet exposure of melanoma cells induces fibrob last activation protein-I+ in fibroblasts: Implications for melanoma invasion. (21491083)WAoster P.... Seifert O.2011FAP
4mRNA expression and BRAF mutation in circulating melanoma cells isolated from peripheral blood with high molecular weight melanoma-associated antigen-specific monoclonal antibody beads. (19233913)Kitago M.... Hoon D.S.2009MITF, MLANA
5The gallium complex KP46 exerts strong activity again st primary explanted melanoma cells and induces apoptosis in melanoma cell line s. (19584767)Valiahdi S.M.... Keppler B.K.2009PARP1, CASP9
6Cadherin-7 interacts with melanoma inhibitory activity protein and negatively modulates melanoma cell migration. (19200257)Winklmeier A.... Bosserhoff A.K.2009CDH7
7Cytoplasmic beta-catenin is lacking in a subset of melanoma-associated naevi, but is detectable in naevus-associated melanomas: potential implications for melanoma tumorigenesis? (19183173)De Panfilis G.... Santini M.2009CTNNB1
8Occurrence of ocular melanoma thirteen years after skin melanoma: two separate primaries or metastatic disease? A case solved with NRAS and CDKN2A (INK4A-ARF) mutational analysis. (18205010)Kusters-Vandevelde H.V.... Blokx W.A.2008NRAS
9The Gln/Gln genotype of XPD codon 751 as a genetic marker for melanoma risk and Lys/Gln as an important predictor for melanoma progression: a case control study in the Swedish population. (18575735)Kertat K.... Zhang H.2008ERCC2
10Melanoma inhibiting activity protein (MIA), beta-2 microglobulin and lactate dehydrogenase (LDH) in metastatic melanoma. (17348447)Cao M.G.... Puig S.2007S100B, B2M, MIA
11Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma. (17384650)Zhuang L.... Hersey P.2007BCL2, STAT3, BCL2L1
12Are all melanomas the same? Spitzoid melanoma is a distinct subtype of melanoma. (16421887)Lee D.A.... Celebi J.T.2006HRAS
13Targeting melanoma cells with human high molecular weight-melanoma associated antigen-specific antibodies elicited by a peptide mimotope: functional effects. (16670313)Luo W.... Ferrone S.2006ANKRD36B
14Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma Study. (16258177)Millikan R.C.... Berwick M.2006ERCC2, XPC, ERCC6
15NGFR-positive desmoplastic melanomas with focal or absent S-100 staining: Further evidence supporting the use of both NGFR and S-100 as a primary immunohistochemical panel for the diagnosis of desmoplastic melanomas. (16625082)Radfar A.... Bhawan J.2006S100B, NGFR
16Expression of the human endogenous retrovirus-K transmembrane envelope, Rec and Np9 proteins in melanomas and melanoma cell lines. (16718269)BA1scher K.... Denner J.2006ERVK-6
17Clusterin (CLU) and melanoma growth: CLU is expressed in malignant melanoma and 1,25-dihydroxyvitamin D3 modulates expression of CLU in melanoma cell lines in vitro. (16886681)Shannan B.... Reichrath J.2006CLU
18Microtubule-associated protein 2, a marker of neuronal differentiation, induces mitotic defects, inhibits growth of melanoma cells, and predicts metastatic potential of cutaneous melanoma. (15920168)Soltani M.H.... Setaluri V.2005MAP2
19Clinical value of protein S100 and melanoma-inhibitory activity (MIA) in malignant melanoma. (15170138)Tas F.... Topuz E.2004S100B
20Comparative histopathology of grey-horse-melanoma and human malignant melanoma. (15541026)Seltenhammer M.H.... Niebauer G.W.2004PCNA, CD44, MKI67
21Immunohistochemical study of melanocytic differentiation antigens in cutaneous malignant melanoma. A comparison of six commercial antibodies and one non-commercial antibody in nodular melanoma, superficially spreading melanoma and lentigo maligna melanoma. (15233017)Kocan P.... Kromydaki A.2004S100B, MITF, MLANA
22Negative association of melanoma differentiation-associated gene (mda-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells. (12533668)Ekmekcioglu S.... Grimm E.A.2003NOS2, IL24
23Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas. (12778069)Edmunds S.C.... Kelsell D.P.2003BRAF
24CD95/Fas signaling in human melanoma cells: conditional expression of CD95L/FasL overcomes the intrinsic apoptosis resistance of malignant melanoma and inhibits growth and progression of human melanoma xenotransplants. (14668794)Eberle J.... Geilen C.C.2003FAS, FASLG
25Immunophenotype of conjunctival melanomas: comparisons with uveal and cutaneous melanomas. (12470134)Iwamoto S.... Schmidt R.2002TYR
26Quantitative RT-PCR assessment of melanoma cells in peripheral blood during immunotherapy for metastatic melanoma. (12459648)Schmidt H.... Nexo E.2002IL2, MLANA
27Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene. (12072203)Moritake H.... Kuroda H.2002MYC, MLANA
28Chromosome 7 aneusomy. A marker for metastatic melanoma? Expression of the epidermal growth factor receptor gene and chromosome 7 aneusomy in nevi, primary malignant melanomas and metastases. (11494118)Udart M.... Peter R.U.2001EGFR
29Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. (11278606)Iida J.... McCarthy J.B.2001MMP16, CD36, CSPG4
30High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families. (10922411)Borg A.... Ingvar C.2000CDK4, CDKN2A
31Melanomas and melanoma cell lines do not express HLA-G, and the expression cannot be induced by gammaIFN treatment. (10958353)Frumento G.... Ferrara G.B.2000HLA-G, IFNA1
32Development of a polynucleotide vaccine from melanoma antigen recognized by T cells-1 and recombinant protein from melanoma antigen recognized by T cells-1 for melanoma vaccine clinical trials. (10838667)Lee S.W.... Conry R.M.2000HLA-A, MLANA
33TRAG-3, a novel cancer/testis antigen, is overexpressed in the majority of melanoma cell lines and malignant melanoma. (11205240)Feller A.J.... Seiden M.V.2000CSAG2, CSAG3
34The emerging role of cytokines in the treatment of advanced melanoma. For the EORTC Melanoma Cooperative Group. (10705235)Keilholz U.... Eggermont A.M.2000IL2, IFNA1
35Expression of catenins and p120cas in melanocytic nevi and cutaneous melanoma: deficient alpha-catenin expression is associated with melanoma progression. (10503270)Zhang X.D.... Hersey P.1999CDH1, CTNNB1, JUP
36Expression of tyrosinase, TRP-1 and TRP-2 in ultraviolet-irradiated human melanomas and melanocytes: TRP-2 protects melanoma cells from ultraviolet B induced apoptosis. (10596909)Nishioka E.... Ichihashi M.1999TYRP1, DCT
37Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study. (9667667)MAPller P.... Schadendorf D.1998IL7
38Antibody responses to melanoma/melanocyte autoantigens in melanoma patients. (9764850)Huang S.K.... Hoon D.S.1998TYRP1, DCT
39Immunomodulatory function of interferon-gamma in patients with metastatic melanoma: results of a phase II-B trial in subjects with metastatic melanoma, ECOG study E 4987. Eastern Cooperative Oncology Group. (9087387)Kirkwood J.M.... Whiteside T.L.1997IFNG
40Expression of E and P-cadherin by melanoma cells decreases in progressive melanomas and following ultraviolet radiation. (8752677)Seline P.C.... Morelli J.G.1996CDH1, CDH3
41Generation of tumor-specific CTLs from melanoma patients by using peripheral blood stimulated with allogeneic melanoma tumor cell lines. Fine specificity and MART-1 melanoma antigen recognition. (7814882)Stevens E.J.... Yannelli J.R.1995IL4
42Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. (8545104)Jiang H.... Fisher P.B.1995IFNB1, IL24
43Suppression of human melanoma cell growth and metastasis by the melanoma-associated antigen CD63 (ME491). (7665237)Radford K.J.... Hersey P.1995CD63
44Phenotype of glutathione S-transferase Mu (GSTM1) and susceptibility to malignant melanoma. MMM group. Multidisciplinary Malignant Melanoma Group. (7640212)Lafuente A.... Trias M.1995GSTM1
45Reactivity of autologous CD4+ T lymphocytes against h uman melanoma. Evidence for a shared melanoma antigen presented by HLA-DR15. (7814883)Takahashi T.... Houghton A.N.1995LINC00328
46Human high molecular weight-melanoma associated antig en mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: modulation of th e immunogenicity in patients with malignant melanoma. (9816036)Mittelman A.... Ferrone S.1995ANKRD36B
47p53 expression in cutaneous malignant melanoma: an immunohistochemical study of 87 cases of primary, recurrent, and metastatic melanoma. (7937717)Barnhill R.L.... Thor A.D.1994TP53
48Decreased expression of human melanoma-associated antigen ME491 along the progression of melanoma pre-canceroses to invasive and metastatic melanomas. (8219756)Kondoh M.... Mishima Y.1993CD63
49Cytotoxic activity toward mouse melanoma following im munization of mice with transfected cells expressing a human melanoma-associate d antigen. (1674672)Nowak J.... Graf L.H.1991ICAM1
50Differential expression of melanoma associated antigens in acral lentiginous melanoma and in nodular melanoma lesions. (1671829)Kageshita T.... Ferrone S.1991TFRC, ANKRD36B

Expression for genes affiliated with Melanoma

about this section
Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Melanoma

Pathways for genes affiliated with Melanoma

about this section
Sources:
36QIAGEN, 20KEGG, 3Cell Signaling Technology, 41Thomson Reuters, 10EMD Millipore, 34PharmGKB
See all sources

Pathways related to melanoma according to GeneDecks:

(show top 50)    (show all 409)
idPathwayScoreTop Affiliating Genes
1Antioxidant Action of Vitamin-C3644.8KIT, KITLG, VEGFB, VEGFC, MYO5A, MYH7B
2Estrogen Pathway3631.7PIK3R3, PIK3R2, PIK3R1, NCOA2, NCOA3, KIT
3cAMP Pathway3630.9PIK3R3, PIK3R2, PIK3R1, PDE1C, PDE3A, PDE3B
4Renin-Angiotensin Pathway3629.9PIK3R3, PIK3R2, PIK3R1, KIT, KITLG, VEGFB
5Endothelin-1 Signaling Pathway3629.6PIK3R3, PIK3R2, PIK3R1, KIT, BRAF, MYC
6Breast Cancer Regulation by Stathmin13626.1PIK3R3, PIK3R2, PIK3R1, VEGFB, BMP2, BMP4
7P2Y Receptor Signaling3624.7PIK3R3, PIK3R2, PIK3R1, KIT, BRAF, VEGFB
8Cell cycle2021.0SFN, PCNA, BUB1, BUB1B, RB1, RBL2
9FAK1 Signaling3620.8PIK3R3, PIK3R2, PIK3R1, BRAF, VCL, RAF1
10Tyrosine Kinases / Adaptors320.8NCK1, RET, KIT, KITLG, VEGFB, VEGFC
11Lymphocyte Signaling319.5NCAM1, NCK1, KIT, KITLG, MYD88, BMI1
12Immune response_IL-2 activation and signaling pathway4119.5PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, REL
13Development_VEGF signaling via VEGFR2 - generic cascades4119.2PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
14RhoGDI Pathway3618.7PIK3R3, PIK3R2, PIK3R1, VEGFB, VEGFC, MYO5A
15Immune response ICOS pathway in T-helper cell1018.0PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
16Signal transduction IP3 signaling1017.9PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
17Actin-Based Motility by Rho Family GTPases3617.4BMP4, BMP7, PAK1, PAK7, ITGA2B, ITGA4
18Development Flt3 signaling1017.3PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, VAV1
19Immune response Fc epsilon RI pathway1017.2PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
20MAP Kinase Signaling317.2BRAF, RASGRP3, RAF1, RAC1, LGALS1, ATF2
21Development_A2A receptor signaling4117.1PIK3CB, PIK3CD, PIK3CA, REL, RELA, RELB
22IL-4 Pathway3617.0PIK3R3, PIK3R2, PIK3R1, BRAF, RAF1, BCL2
23Development_A3 receptor signaling4117.0PIK3R5, PIK3CG, REL, RELA, RELB, MYC
24Endometrial cancer2017.0PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
25NGF Pathway3616.9PIK3R3, PIK3R2, PIK3R1, BRAF, MYC, RAP1A
26Viral myocarditis2016.9MYH7B, RAC1, BID, LAMA2, FYN, CD28
27Apoptosis and survival_Role of CDK5 in neuronal death and survival4116.8PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
28Mucin expression in CF via TLRs, EGFR signaling pathways4116.8REL, RELA, RELB, MYD88, RAF1, CHUK
29Fc gamma R-mediated phagocytosis2016.6PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
30Immune response Oncostatin M signaling via MAPK in human cells1016.6RAF1, RAC1, CEBPB, ATF2, JUN, JUNB
31Selected targets of p531016.6SERPINB5, SEMA3F, LIF, BCL2, BAX, S100A2
32IL-3 Pathway3616.2PIK3R3, PIK3R2, PIK3R1, BRAF, RAF1, BCL2L1
33Intestinal immune network for IgA production2016.1CD28, CD86, CD40LG, CD80, CD40, ITGA4
34B cell receptor signaling pathway2016.1PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
35Transcription_Androgen Receptor nuclear signaling4116.0NCOA2, RAF1, FZD2, CDKN1A, MMP2, AR
36VEGF Pathway3615.9PIK3R3, PIK3R2, PIK3R1, VEGFC, RAF1, KDR
37Development_Angiopoietin - Tie2 signaling4115.9PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
38Development A2B receptor- action via G-protein alpha s1015.9PIK3CB, PIK3CD, PIK3CA, REL, RELA, RELB
39Development_PDGF signaling via MAPK cascades4115.9PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
40Fc epsilon RI signaling pathway2015.2PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
41Development GDNF family signaling1015.2PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, NCK1
42Development_ERBB-family signaling4115.1PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
43Transcription_Receptor-mediated HIF regulation4115.1PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
44Pathway_PA1659800503414.9BRAF, MYC, RAF1, KDR, JUN, FLT1
45Development CNTF receptor signaling1014.8PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
46G-protein signaling_Ras family GTPases in kinase cascades (scheme)4114.6BRAF, RAP1A, RAF1, RAC1, PAK1, CEBPB
47Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR14113.9PIK3CB, PIK3CD, PIK3R2, PIK3R1, BAD, MAP2K2
48Immune response Role of DAP12 receptors in NK cells1012.8KIR2DL1, KIR2DL2, VAV2, ZAP70, ARPC1B, HLA-B
49Pancreatic cancer2012.3PIK3R3, PIK3R2, PIK3R5, BRCA2, RALGDS, CDK6
50Translation Regulation activity of EIF4F1012.1PIK3CB, PIK3CD, PIK3R3, PIK3R2, PAK1, MAPK12

Compounds for genes affiliated with Melanoma

about this section
Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
See all sources

Compounds related to melanoma according to GeneDecks:

(show top 50)    (show all 417)
idCompoundScoreTop Affiliating Genes
1cholesterol32 9 18 9 52.9PIK3CB, PIK3CA, PIK3R1, PIK3C2A, LRAT, LRP1
2paclitaxel32 34 9 9 51.8PIK3CA, PIK3CG, NCL, KIT, KITLG, PCNA
3progesterone32 42 9 18 9 52.0PIK3CA, PIK3R1, LRAT, NCAM1, NCOA2, NCOA3
4forskolin32 42 9 9 42.7PIK3R1, PDE3A, PDE3B, PDE4A, PDE4B, CNTF
5ribonucleic acid32 34.3KLF6, RET, KIT, KITLG, SFTPC, SERPINB2
6gtp32 33.0PIK3CA, PIK3R1, PIK3C2A, PDE3B, RECK, VTI1B
7fmlp32 29.9PIK3CG, PDE4A, SELP, SERPINA3, VIM, VCAM1
8resveratrol32 9 18 9 32.6PIK3CA, PIK3CG, PCNA, RB1, BSG, BRCA1
9bromodeoxyuridine32 28.7PIK3CA, PIK3R1, NCAM1, NCOA3, CNTF, KITLG
10adriamycin32 28.6RB1, VIM, BRCA1, BRCA2, VDR, MYC
11potassium32 9 18 9 28.1PIK3CA, PIK3C2A, NCAM1, PDE3B, PDE4A, CNTF
12pdtc32 24.7PIK3CA, PIK3CG, SELE, SETD2, SERPINB5, VCAM1
13gf 109203x32 42 25.1PIK3CB, PIK3CG, KITLG, VEGFA, VCL, RAP1A
14histidine32 23.3PDE3B, PDE4A, KITLG, RARA, KCNH2, SCT
15sucrose32 9 18 9 25.2LRP1, RECK, BSG, VDAC1, VCL, MYO5A
16hydrocortisone32 9 9 22.8KITLG, VIM, BMP6, LIF, PBX1, KDR
17trastuzumab32 34 9 9 23.4PIK3CA, PIK3R1, PIK3CG, KIT, VEGFC, RAF1
18vanadate32 20.1NCK1, SETD2, VCL, BLZF1, KCNMA1, LCK
19thalidomide32 42 9 9 23.0PDE4A, VTN, VEGFA, BIRC2, BIRC3, BIRC5
20carbohydrates32 19.8RECK, SELE, SELP, BSG, VCAM1, BLZF1
21leukotriene b432 42 18 21.8PDE4A, SELP, RAC1, LAP3, ITGAL, ITGAM
22procollagen32 19.5PCNA, VIM, BMP2, BMP6, LGALS1, P4HB
23depsipeptide32 19.1KITLG, RB1, SERPINB5, BRAF, MYC, RAF1
24bleomycin32 9 9 21.0SFTPC, BRCA1, BRCA2, MVP, LAP3, XRCC1
25pge132 18.9PIK3C2A, PDE3B, PDE4A, VWF, SERPINE1, VIP
26silymarin32 18.4PCNA, VEGFA, BMP6, BIRC5, PARP1, CHUK
27atorvastatin32 34 9 18 9 22.4PIK3C2A, VWF, SELE, SELP, VEGFA, LPL
28silver32 17.8NCL, RECK, PCNA, SERPINA3, RAB27A, BLZF1
29ornithine32 18 18.6SERPINB2, MYC, MYCN, RARA, CLU, MXI1
30methylcellulose32 17.4KIT, KITLG, VCL, VAV1, MYB, BMP2
31tarc32 17.2CD4, CDH1, ITGA4, IL10, IL13, IL18
32leptomycin b32 17.2BRCA1, RANBP2, RAN, BIRC5, LGALS3, CDKN1A
33sulforaphane32 17.2PIK3CG, RB1, PARP1, JUN, CDKN1A, CDC25C
34nifedipine32 9 9 19.1PIK3CG, SELE, SERPINE1, VIP, BMP2, BMP6
35mevalonate32 16.7SERPINE1, VCAM1, BMP2, RAP1A, RAC1, BCL2L1
36poly(i-c)32 16.5VCAM1, CHUK, CD69, IRF1, IL15, IL18
37menadione32 9 18 9 19.4XDH, CDK2, CDC25C, CDK4, CDK1, IRAK1
38sorafenib32 9 9 18.2RET, KIT, BRAF, VEGFA, RAF1, BIRC3
39guanidine hydrochloride32 15.6CNTF, VWF, SERPINA3, LPL, VDAC1, BMP2
40erythromycin32 9 9 17.5PIK3C2A, VIP, VCAM1, BCL2L1, KCNH2, CD40LG
41radicicol32 42 9 9 17.9PIK3CG, VEGFA, RAF1, JUN, AR, GSN
42phenylephrine32 9 18 9 17.9LPL, RAF1, RAC1, LIF, KCNMA1, LEP
43bisindolylmaleimide32 14.6PIK3CB, RAF1, RAC1, S100B, CFLAR, ITGA2
44titanium32 14.5VTN, VIM, VCL, BMP2, BMP4, BMP7
45manumycin32 13.7RAF1, CHUK, INSR, ANXA5, MAPK8, MAPK14
46cyclophosphamide32 34 9 9 15.1MVP, ITGA4, ITGAL, ITGB2, F8, TRB@
47threonine32 INFREL, RET, RBL2, NBN, LPAR3, BMP2
48calcium32 9 18 9 INFPIK3CD, PIK3C2A, PI3, LRP1, KL, NCL
49atp32 INFPIK3CB, PIK3CA, PIK3C2A, LRAT, NCAM1, NCL
50glucose32 INFPDE4A, CNTF, KIT, KISS1, SETD2, SERPINF1

GO Terms for genes affiliated with Melanoma

about this section
Sources:
12Gene Ontology
See all sources

Cellular components related to melanoma according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:005737INFPIR, PIK3R5, PIK3C2A, PIK3CG, LRP1, KLF6
2plasma membraneGO:00588688.8PIK3CD, PIK3R1, PIK3C2A, PIK3CG, PIGU, KL
3extracellular regionGO:00557658.5KL, NCAM1, PDCD1LG2, KISS1, KITLG, VWF
4integral to plasma membraneGO:00588749.1LRP1, KL, RET, KIR3DL2, KIR2DL1, KIR2DL3
5nucleoplasmGO:00565440.5RFC5, NCOA2, NCOA3, REL, RELA, PCNA
6membraneGO:01602029.4PIK3R5, PIK3CG, PDE3B, PDE4A, RECK, GCNT2
7external side of plasma membraneGO:00989724.8NCAM1, KIT, VWF, SELP, SEMA7A, VCAM1
8extracellular matrixGO:03101217.9VWF, VTN, SFRP2, SERPINF1, SERPINE1, LPL
9platelet alpha granule lumenGO:03109314.3VWF, SERPINA1, SERPINE1, VEGFA, VEGFB, VEGFC
10extracellular spaceGO:005615INFKL, CNTF, KIT, KITLG, VTN, SFN
11perinuclear region of cytoplasmGO:048471INFLRAT, PDE4A, PDE4B, BUB1B, SELE, LPXN
12cytosolGO:005829INFPIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
13nucleusGO:005634INFPIK3CB, PIR, PIK3R5, PIK3C2A, LRP1, KLF5
14cell surfaceGO:009986INFNCAM1, KISS1R, VEGFA, LPAR1, LPL, VCAM1

Biological processes related to melanoma according to GeneDecks:

(show top 50)    (show all 86)
idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:00691543.3PDCD1, SFN, BUB1, BUB1B, NBN, VIM
2blood coagulationGO:00759637.6PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
3positive regulation of cell proliferationGO:00828434.7KLF5, CNTF, KIT, SFRP2, NBN, VIP
4immune responseGO:00695532.0PDCD1LG2, KIR2DL1, KIR2DL3, KIR3DL1, VTN, SEMA7A
5negative regulation of apoptotic processGO:04306630.3PIK3CG, PDE3A, RELA, SERPINE1, BRAF, VEGFA
6virus-host interactionGO:01904828.7PIK3R1, RELA, KIN, BUB1, BTRC, RB1
7cell adhesionGO:00715528.6NCAM1, KITLG, VWF, VTN, PCDHB11, SELP
8response to drugGO:04249328.5PDE3A, PDE4A, SFRP2, NBN, VEGFC, LPL
9cell proliferationGO:00828328.2KITLG, KIF2C, VTI1B, SFN, PCNA, BUB1
10inflammatory responseGO:00695427.9PIK3CD, PIK3CG, RELA, KIT, SELE, SELP
11negative regulation of transcription from RNA polymerase II promoterGO:00012227.7NCOA2, VDR, MYC, MYB, BMI1, BMP2
12innate immune responseGO:04508727.4PIK3CD, PIK3CG, RELA, MYD88, CLEC4C, CLU
13cell-cell signalingGO:00726725.7SFRP2, BMP2, S100A9, CGA, CEACAM6, FZD2
14angiogenesisGO:00152525.4PIK3CA, PIK3CG, KLF5, NCL, PDE3B, WARS
15cytokine-mediated signaling pathwayGO:01922125.2KLF6, NCAM1, RELA, KIT, VCAM1, MYD88
16platelet activationGO:03016825.1PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
17axon guidanceGO:00741125.0NCAM1, NCK1, NCK2, SEMA7A, SEMA3F, VAV2
18nerve growth factor receptor signaling pathwayGO:04801124.0PIK3CB, PIK3CA, PIK3R2, PIK3R1, NDN, PDE1C
19positive regulation of apoptotic processGO:04306523.3SFRP2, LPAR1, BMP2, BMP4, RARB, LILRB1
20protein phosphorylationGO:00646823.0PIK3CD, RET, BRAF, RARA, RAF1, BIRC5
21induction of apoptosisGO:00691722.0NACC1, BOK, PAWR, BCL2L11, BBC3, LCK
22fibroblast growth factor receptor signaling pathwayGO:00854321.4PIK3CA, PIK3R1, KL, PDE1C, BRAF, RAF1
23response to hypoxiaGO:00166621.1SERPINA1, VEGFA, VCAM1, BMP2, RAF1, PAK1
24cell surface receptor signaling pathwayGO:00716620.7BSG, MYD88, BIRC2, BIRC3, CLEC4A, LEPR
25leukocyte migrationGO:05090020.3PIK3CB, PIK3CA, PIK3R2, PIK3R1, SELP, BSG
26positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312320.3REL, RELA, LPAR1, MYD88, BIRC2, BIRC3
27positive regulation of cell migrationGO:03033520.2RET, VEGFA, BMP2, KDR, BCAR1, LEF1
28insulin receptor signaling pathwayGO:00828620.2PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3C2A
29epidermal growth factor receptor signaling pathwayGO:00717319.9PIK3CA, PIK3R1, PIK3C2A, NCK2, PDE1C, RAF1
30cell cycle arrestGO:00705019.6RB1, NBN, MYC, RASSF1, MSH2, ATM
31positive regulation of ERK1 and ERK2 cascadeGO:07037419.4SEMA7A, BRAF, VEGFB, BMP2, BMP4, KDR
32response to organic cyclic compoundGO:01407019.1SELP, SERPINA1, BMP4, LEF1, BAK1, P2RX7
33chemotaxisGO:00693518.8PIK3CB, S100A8, S100A9, L1CAM, FOSL1, FGF2
34positive regulation of gene expressionGO:01062818.4NCOA3, RELB, KIT, BRAF, VEGFA, VDR
35agingGO:00756818.1KL, SERPINF1, VDR, VCAM1, BAK1, P2RY1
36activation of MAPK activityGO:00018717.9PIK3CB, KIT, LPAR1, LPAR3, UBC, P2RX7
37activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691917.9PDCD6, BOK, MYC, BCL2L11, BBC3, LCK
38positive regulation of peptidyl-tyrosine phosphorylationGO:05073117.1KITLG, VTN, VEGFA, VEGFB, LIF, MTOR
39type I interferon-mediated signaling pathwayGO:06033716.7USP18, XAF1, JAK1, ISG15, ISG20, IRF1
40phosphatidylinositol-mediated signalingGO:04801516.5PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3C2A, PCNA
41positive regulation of MAPK cascadeGO:04341016.2CNTF, KIT, LPAR1, LPAR3, LIF, KDR
42MAPK cascadeGO:00016516.0RET, MYC, RASGRP3, RAF1, PAK1, CDK1
43positive regulation of cell divisionGO:05178115.9VEGFA, VEGFB, VEGFC, YBX1, FIGF, FGF1
44response to ethanolGO:04547115.8BCL2, BAK1, S100A8, S100A9, FYN, CDK1
45positive regulation of protein kinase B signaling cascadeGO:05189715.8PIK3R5, PIK3CG, VEGFB, CHI3L1, MTDH, MTOR
46activation of MAPKK activityGO:00018613.3KIDINS220, KISS1R, BMP4, RAF1, JAK2, GRM1
47anti-apoptosisGO:006916INFPIK3CA, RELA, SERPINB9, SERPINB2, BRAF, VEGFB
48negative regulation of cell proliferationGO:008285INFNDN, NCK2, WARS, KISS1R, SFN, SFRP2
49signal transductionGO:007165INFPIK3CB, PIK3CD, NCK2, PDCD1, PDE1C, PDE4A
50cell migrationGO:016477INFPIK3CB, NCK2, VAV2, PAK7, BCAR1, BAMBI

Molecular functions related to melanoma according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00552444.3PIK3CB, PIK3CD, PIK3CA, PIK3C2A, PIK3CG, RFC5
2protein homodimerization activityGO:04280331.2PDCD6, KIT, VWF, SFTPC, GCA, VEGFA
3receptor bindingGO:00510224.1NCK1, SERPINE1, LPL, BMP2, RARA, RAB8B
4cytokine activityGO:00512523.9CNTF, KITLG, VEGFA, BMP2, BMP4, BMP6
5growth factor activityGO:00808323.0CNTF, KITLG, VEGFA, VEGFB, VEGFC, BMP2
6protein heterodimerization activityGO:04698222.9GCA, BRAF, VEGFA, VEGFB, BOK, MYC
7transcription factor bindingGO:00813420.8RELA, RB1, RBL1, NBN, NAB2, MYC
8enzyme bindingGO:01989919.9RFC5, BRCA1, RARA, RAC1, BLZF1, BIRC5
9receptor activityGO:00487219.7LRP1, RET, KIR2DL1, KIR2DL3, SEMA7A, SEMA3F
10heparin bindingGO:00820117.9VTN, SELP, VEGFA, VEGFB, LPL, BMP4
11protein bindingGO:005515INFPIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIR
12protein kinase bindingGO:019901INFRELA, VIM, LLGL1, ZFP36, PAK1, BCAR1
13integrin bindingGO:005178INFVWF, VTN, SFRP2, SEMA7A, VCAM1, KDR
14identical protein bindingGO:042802INFRELA, PCNA, VIM, MYD88, RAF1, RASSF1

Sources for Melanoma

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
Browse MalaCards: 1-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z