MCID: MLN008
MIFTS: 56

Melanoma malady

Cancer category

Summaries for Melanoma

Sources:
8Disease Ontology, 34MedlinePlus, 46Novus Biologicals, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Melanoma is the most serious type of skin cancer. often the first sign of melanoma is a change in the size, shape, color, or feel of a mole. most melanomas have a black or black-blue area. melanoma may also appear as a new mole. it may be black, abnormal, or "ugly looking." thinking of "abcde" can help you remember what to watch for: asymmetry - the shape of one half does not match the other border - the edges are ragged, blurred or irregular color - the color is uneven and may include shades of black, brown and tan diameter - there is a change in size, usually an increase evolving - the mole has changed over the past few weeks or months surgery is the first treatment of all stages of melanoma. other treatments include chemotherapy and radiation, biologic, and targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Melanoma, also known as malignant melanoma, is related to ocular melanoma and oculocutaneous albinism. An important gene associated with Melanoma is MFI2 (antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5). The drugs temozolomide and carmustine and the compound hemocyanin have been mentioned in the context of this disorder. Related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A cell type cancer that has material basis in abnormally proliferating cells derived from melanocytes which are found in skin, the bowel and the eye.

Novus Biologicals:46 Melanoma is a malignant tumor that results from uncontrolled growth of pigmented cells, called melanocytes. Several types of melanoma exist, including superficial spreading melanoma, nodular melanoma and lentigo melanoma. Melanoma diagnosis is traditionally supported by the presence of the S-100 protein marker and HMB-45, however research has determined the sensitivity and specificity of three novel antibodies as markers for melanoma: Mitf, Melan-A and tyrosinase.

Wikipedia:64 Melanoma i/ˌmɛləˈnoʊmə/ (from Greek μέλας — melas, \"dark\") is a malignant tumor of... more...

Description from OMIM:47 155600

Aliases & Classifications for Melanoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 47OMIM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

melanoma 8 10 45 34 31 61
malignant melanoma 8
cutaneous melanoma 61
naevocarcinoma 8


External Ids:

Disease Ontology8 DOID:1909
MeSH35 D008545
NCIt40 C3224
OMIM47 155600
ICD1025 D03.9

Related Diseases for Melanoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Melanoma family:

familial melanoma

Diseases related to Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 512)
idRelated DiseaseScoreTop Affiliating Genes
1ocular melanoma31.5MAGEA3, MAGEA1
2oculocutaneous albinism30.4SLC45A2
3albinism30.4SLC45A2
4arthritis30.1CXCL1
5angiomyolipoma29.9PMEL
6cutaneous malignant melanoma11.1
7amelanotic melanoma10.9
8familial melanoma10.8
9lentigo maligna melanoma10.8
10acral lentiginous melanoma10.8
11posterior uveal melanoma10.7
12superficial spreading melanoma10.7
13n syndrome10.6
14clear cell sarcoma10.6
15dysplastic nevus syndrome10.6
16microphthalmia10.6
17vulvar melanoma10.5
18hypoxia10.5
19orbital melanoma10.5
20nodular malignant melanoma10.5
21basal cell carcinoma10.5
22spitz nevus10.5
23squamous cell carcinoma10.5
24melanoma, cutaneous malignant, 110.5
25vitiligo10.5
26atypical mole syndrome10.4
27retinal melanoma10.4
28malignant breast melanoma10.4
29soft tissue sarcoma10.4
30burn scar10.4
31neurocutaneous melanosis10.4
32xeroderma pigmentosum10.4
33teratoma10.4
34malignant conjunctiva melanoma10.4
35melanoma, malignant, somatic10.4
36adenocarcinoma10.3
37melanoma, cutaneous malignant, 210.3
38esophagus melanoma10.3
39primary gastrointestinal melanoma10.3
40colorectal cancer10.3
41neovascular glaucoma10.3
42ovarian cystic teratoma10.3
43malignant spindle cell melanoma10.3
44malignant ovarian cyst10.3
45melanoma astrocytoma syndrome10.2
46cervix melanoma10.2
47melanoma-pancreatic cancer syndrome10.2
48vaccinia10.2
49gallbladder melanoma10.2
50primary malignant melanoma of the cervix10.2

Graphical network of the top 20 diseases related to Melanoma:



Diseases related to melanoma

Clinical Features for Melanoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

155600

Drugs & Therapeutics for Melanoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Melanoma

Anatomical Context for Melanoma

Animal Models for Melanoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Melanoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.5SLC45A2, KISS1, IL24, MCAM, CD63, MFI2

Publications for Melanoma

Sources:
51PubMed
See all sources

Articles related to Melanoma:

(show top 50)    (show all 9982)
idTitleAuthorsYear
1
CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and I^1-integrin signaling pathways. (22832488)
2013
2
The use of high dose rate brachytherapy palliation after failed palliative external beam radiotherapy for a cutaneous malignant melanoma of the foot: a case report. (21469995)
2011
3
Post-transcriptional regulation controlled by E-cadherin is important for c-Jun activity in melanoma. (20977688)
2011
4
Lentivector prime and vaccinia virus vector boost generate high-quality CD8 memory T cells and prevent autochthonous mouse melanoma. (21746967)
2011
5
Evaluation of EMMPRIN and MMP-2 in the prognosis of primary cutaneous malignant melanoma. (19921476)
2010
6
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. (21179167)
2010
7
Osteopontin and 'melanoma inhibitory activity': comparison of two serological tumor markers in metastatic uveal melanoma patients. (19270465)
2009
8
Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt. (19412428)
2009
9
Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant. (18813352)
2008
10
Malignant amelanotic melanoma behind the left eye in a female Crj:CD(SD)IGS rat: a case report. (18725473)
2008
11
PAX4 has the potential to function as a tumor suppressor in human melanoma. (18949370)
2008
12
Transcriptional regulation of ASK/Dbf4 in cutaneous melanoma is dependent on E2F1. (18503552)
2008
13
Imatinib targeting of KIT-mutant oncoprotein in melanoma. (19047099)
2008
14
Phosphorylation of ectopically expressed L-plastin enhances invasiveness of human melanoma cells. (17290393)
2007
15
Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. (17611626)
2007
16
Promoter methylation status of multiple genes in uveal melanoma. (17898258)
2007
17
Analysis of neovasculature in uveal melanoma by targeting the TGFbeta-binding receptor endoglin: is there prognostic relevance of proliferating endothelium? (16523306)
2006
18
The Raf inhibitor BAY 43-9006 (Sorafenib) induces caspase-independent apoptosis in melanoma cells. (16452220)
2006
19
Sympathetic ophthalmia after surgical resection of iridociliary melanoma. A case report. (16523295)
2006
20
Melanocortin receptor-1 gene polymorphisms and the risk of cutaneous melanoma in a low-risk southern European population. (16601669)
2006
21
Adoptive transfer of tumor-reactive Melan-A-specific CTL clones in melanoma patients is followed by increased frequencies of additional Melan-A-specific T cells. (16177129)
2005
22
Notch and NOXA-related pathways in melanoma cells. (16363061)
2005
23
Nevus distribution in a Utah melanoma kindred with a temperature-sensitive CDKN2A mutation. (16354203)
2005
24
Phosphorothioate oligodeoxynucleotides and G3139 induce apoptosis in 518A2 melanoma cells. (15713901)
2005
25
Expression of the c-kit receptor in choroidal melanomas. (12690299)
2003
26
Regulation of melanoma cell migration and invasion by laminin-5 and alpha3beta1 integrin (VLA-3). (11964076)
2002
27
Interferon stimulated gene 15 constitutively produced by melanoma cells induces e-cadherin expression on human dendritic cells. (12067988)
2002
28
The p75 neurotrophin receptor, relative to other Schwann cell and melanoma markers, is abundantly Expressed in spindled melanomas. (11481518)
2001
29
Facts and pitfalls in the detection of tyrosinase mRNA in the blood of melanoma patients by RT-PCR. (11092037)
2001
30
Microvascular permeability of human melanoma xenografts to macromolecules: relationships to tumor volumetric growth rate, tumor angiogenesis, and VEGF expression. (11254398)
2001
31
Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model. (11156402)
2000
32
Effects of betulinic acid alone and in combination with irradiation in human melanoma cells. (10771474)
2000
33
Immunodetection of gastrin-releasing peptide in malignant melanoma cells. (10985675)
2000
34
Selective deletion of exon 1 beta of the p19ARF gene in metastatic melanoma cell lines. (9790510)
1998
35
Immunochemotherapy with recombinant interferon-alpha 2b plus dacarbazine in the treatment of advanced malignant melanoma. (9429226)
1997
36
Analysis of MAGE-3-specific cytolytic T lymphocytes in human leukocyte antigen-A2 melanoma patients. (9044853)
1997
37
Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro. (9139875)
1997
38
Expression and activity of signaling molecules in T lymphocytes obtained from patients with metastatic melanoma before and after interleukin 2 therapy. (9816296)
1996
39
Amelanotic lentigo maligna melanoma: a diagnostic conundrum-- presentation of four new cases. (8640669)
1996
40
Lymphocyte-melanoma interaction: role of surface molecules. (7597291)
1995
41
Efficient transduction of early passage human melanoma to secrete IL-4. (7602147)
1995
42
Establishment of a melanoma cell line with metastatic characteristics. (8652447)
1995
43
Elevated serum levels of interleukin-10 in patients with metastatic malignant melanoma. (7734958)
1995
44
Visual function following enucleation or episcleral plaque radiotherapy for posterior uveal melanoma. (8002837)
1994
45
Phorbol ester induced rapid attachment and spreading of melanoma cells and the role of extracellular matrix proteins. (7515859)
1994
46
PC-10 immunostaining of proliferating cell nuclear antigen in posterior uveal melanoma. Enucleation versus enucleation postirradiation groups. (7905616)
1994
47
Characterization of autologous tumor-specific T-helper 2 cells in tumor-infiltrating lymphocytes from a patient with metastatic melanoma. (7914181)
1994
48
Phase II trial of recombinant tumor necrosis factor in disseminated malignant melanoma. (1590281)
1992
49
Acral lentiginous melanoma of the oral cavity. (6841121)
1983
50
Occult ocular melanoma. (1082080)
1975

Genetic Variations for Melanoma

Expression for genes affiliated with Melanoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Melanoma

Search GEO for disease gene expression data for Melanoma.

Pathways for genes affiliated with Melanoma

Compounds for genes affiliated with Melanoma

Sources:
45Novoseek
See all sources

Compounds related to Melanoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hemocyanin4510.9MAGEA3, PMEL

GO Terms for genes affiliated with Melanoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanin biosynthetic processGO:04243810.9SLC45A2, PMEL

Products for genes affiliated with Melanoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Melanoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet