MCID: MLN008
MIFTS: 65

Melanoma malady

Cancer diseases category

Summaries for Melanoma

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Sources:
8Disease Ontology, 33MedlinePlus, 45Novus Biologicals, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Melanoma is the most serious type of skin cancer. often the first sign of melanoma is a change in the size, shape, color, or feel of a mole. most melanomas have a black or black-blue area. melanoma may also appear as a new mole. it may be black, abnormal, or "ugly looking." thinking of "abcde" can help you remember what to watch for: asymmetry - the shape of one half does not match the other border - the edges are ragged, blurred or irregular color - the color is uneven and may include shades of black, brown and tan diameter - there is a change in size, usually an increase evolving - the mole has changed over the past few weeks or months surgery is the first treatment of all stages of melanoma. other treatments include chemotherapy and radiation, biologic, and targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Melanoma, also known as malignant melanoma, is related to intraocular melanoma and sarcoma. An important gene associated with Melanoma is MFI2 (antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5). The drugs carmustine and dacarbazine and the compound hemocyanin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lymph node, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A cell type cancer that has material basis in abnormally proliferating cells derived from melanocytes which are found in skin, the bowel and the eye.

Novus Biologicals:45 Melanoma is a malignant tumor that results from uncontrolled growth of pigmented cells, called melanocytes. Several types of melanoma exist, including superficial spreading melanoma, nodular melanoma and lentigo melanoma. Melanoma diagnosis is traditionally supported by the presence of the S-100 protein marker and HMB-45, however research has determined the sensitivity and specificity of three novel antibodies as markers for melanoma: Mitf, Melan-A and tyrosinase.

Wikipedia:63 Melanoma (i/ˌmɛləˈnoʊmə/; from Greek μέλας melas, \"dark\") is a malignant tumor of... more...

Description from OMIM:46 155600

Aliases & Classifications for Melanoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

melanoma 8 10 44 33 30 60
malignant melanoma 8
cutaneous melanoma 60
naevocarcinoma 8


External Ids:

Disease Ontology8 DOID:1909
MeSH34 D008545
NCIt39 C3224
OMIM46 155600
ICD1025 D03.9

Related Diseases for Melanoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Melanoma family:

Familial Melanoma

Diseases related to Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 601)
idRelated DiseaseScoreTop Affiliating Genes
1intraocular melanoma31.0PMEL, MAGEA3, MAGEA1
2sarcoma31.0MAGEA3, MAGEA1
3breast cancer30.7KISS1, IL24, CD63, CXCL1, MAGEA1, MAGEA3
4leukemia30.5CSPG4, PRAME, MRPL28, MAGEA3, MAGEA1, CXCL1
5lung cancer30.4MAGEA3
6oculocutaneous albinism30.3SLC45A2
7albinism30.3SLC45A2
8ocular melanoma30.3MAGEA3, MAGEA1
9prostate cancer30.3MCAM, KISS1, IL24, CD63, CXCL1
10hepatocellular carcinoma30.3MAGEA1, MAGEA3, CD63, KISS1
11arthritis30.1CXCL1
12ovarian cancer30.0MAGEA1, MAGEA3, CXCL1, IL24
13angiomyolipoma29.9PMEL
14rheumatoid arthritis29.9CXCL1
15influenza29.7MAGEA3, IL24, MRPL28, IFIH1, PMEL
16cholangiocarcinoma29.5MAGEA3
17skin melanoma11.0
18familial melanoma10.9
19amelanotic melanoma10.9
20choroiditis10.8
21acral lentiginous melanoma10.7
22posterior uveal melanoma10.7
23clear cell sarcoma10.6
24dysplastic nevus syndrome10.6
25microphthalmia10.5
26renal cell carcinoma10.5
27vulvar melanoma10.5
28hepatitis10.5
29nodular malignant melanoma10.5
30basal cell carcinoma10.5
31keratosis10.4
32vitiligo10.4
33squamous cell carcinoma10.4
34malignant choroid melanoma10.4
35pancreatitis10.4
36retinal melanoma10.4
37malignant breast melanoma10.4
38burns10.3
39meningeal melanoma10.3
40retinitis10.3
41burn scar10.3
42xeroderma pigmentosum10.3
43cystic teratoma10.3
44retinoblastoma10.3
45thyroiditis10.3
46malignant teratoma10.3
47seborrheic keratosis10.3
48adenocarcinoma10.3
49meningitis10.3
50pancreatic cancer10.3

Graphical network of the top 20 diseases related to Melanoma:



Diseases related to melanoma

Clinical Features for Melanoma

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Sources:
46OMIM
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Clinical features from OMIM:

155600

Drugs & Therapeutics for Melanoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Melanoma

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Anatomical Context for Melanoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Melanoma:

32
Skin, T cells, Lymph node, Endothelial, Eye, Lung, Breast, Brain, Liver, Testes, Bone, Monocytes, Colon, Testis, Thyroid, Kidney, Prostate, Nk cells, Bone marrow, Pancreas, B cells, Myeloid, Cervix, Ovary, Spinal cord, Pituitary, Placenta, Small intestine, Tongue, Whole blood, Retina, Heart, Pineal, Smooth muscle, Uterus, Adrenal gland, Spleen, Adipocyte

Animal Models for Melanoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Melanoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.5SLC45A2, KISS1, IL24, MCAM, CD63, MFI2

Publications for Melanoma

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Sources:
50PubMed
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Articles related to Melanoma:

(show top 50)    (show all 9933)
idTitleAuthorsYear
1
Temporal and spatial melanoma trends in austria: an ecological study. (24398911)
2014
2
Predictive factors for the development of brain metastases in patients with malignant melanoma: a study by the Anatolian society of medical oncology. (24292400)
2014
3
A probabilistic analysis of mitotic counts in melanoma. (24436268)
2014
4
Analysis of the B-RafV600E mutation in cutaneous melanoma patients with occupational sun exposure. (24424406)
2014
5
Unusual Morphologic Presentations of Blastic Plasmacytoid Dendritic Cell Neoplasm: Report of Two Cases Misdiagnosed as Melanoma and Leprosy. (23515558)
2013
6
Recurrent lentigo maligna melanoma commingling the tumour nests of a basal cell carcinoma. (23623186)
2013
7
Medical approaches to non-melanoma skin cancer. (24236820)
2013
8
Prevalence of the E318K MITF germline mutation in Italian melanoma patients: associations with histological subtypes and family cancer history. (23167872)
2013
9
Melanoma cells use Thy-1 (CD90) on endothelial cells for metastasis formation. (23159525)
2013
10
Stem cell marker CD271 is expressed by vasculogenic mimicry-forming uveal melanoma cells in three-dimensional cultures. (22419851)
2012
11
Melanoma-associated cancer-testis antigen 16 (CT16) regulates the expression of apoptotic and antiapoptotic genes and promotes cell survival. (23028975)
2012
12
Functional effects of GRM1 suppression in human melanoma cells. (22798429)
2012
13
Cutaneous halo nevi following plaque radiotherapy for uveal melanoma. (22084224)
2011
14
In situ expression of tumor antigens by messenger RNA-electroporated dendritic cells in lymph nodes of melanoma patients. (19318559)
2009
15
Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells. (19483722)
2009
16
GAB2 amplifications refine molecular classification of melanoma. (19509136)
2009
17
Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. (19470611)
2009
18
Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells. (19667161)
2009
19
Unusual presentation of metastatic amelanotic melanoma of unknown primary origin as a solitary breast lump. (18971788)
2008
20
Versican overexpression in cutaneous malignant melanoma. (19073385)
2008
21
Molecular genetic analysis of NBS1 in German melanoma patients. (17496786)
2007
22
GM-CSF plus antigenic peptide vaccination in locally advanced melanoma patients. (17803450)
2007
23
Multitarget fluorescence in situ hybridization and melanoma antigen genes analysis in primary bladder carcinoma. (16364760)
2006
24
Enhanced survival associated with vitiligo expression during maintenance biotherapy for metastatic melanoma. (16946711)
2006
25
Therapeutic targets in melanoma: map kinase pathway. (16901402)
2006
26
Recurrent patterns of dual RB and p53 pathway inactivation in melanoma. (16354195)
2005
27
Phase II trial of intralesional therapy with interleukin-2 in soft-tissue melanoma metastases. (14583759)
2003
28
IL-12 or IL-15, unlike IL-2, does not interact with histamine in augmenting cytotoxicity of splenocytes against melanoma cells and YAC-1 cells. (11836621)
2002
29
Expression of angiogenic factors Cyr61 and tissue factor in uveal melanoma. (12470148)
2002
30
Hemoglobin binds melanoma cell tissue factor and enhances its procoagulant activity. (11943929)
2002
31
Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3- expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. (11870224)
2002
32
Diagnostic utility of microphthalmia transcription factor in malignant melanoma and other tumors. (11556535)
2001
33
Histopathologic features of malignant peripheral nerve sheath tumor are not restricted to metastatic malignant melanoma and can be found in primary malignant melanoma also. (11023110)
2000
34
Plasma Fas ligand, an inducer of apoptosis, and plasma soluble Fas, an inhibitor of apoptosis, in advanced melanoma. (11095407)
2000
35
Interleukin-2 enhances the growth of human melanoma cells derived form primary but not from metastatic tumours. (11125310)
2000
36
Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression. (10555745)
1999
37
Involvement of CD44 in matrix metalloproteinase-2 regulation in human melanoma cells. (9935179)
1999
38
Identification of two distinct deletion targets at 11q23 in cutaneous malignant melanoma. (9935201)
1999
39
Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells. (9872567)
1998
40
Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers. (9324133)
1997
41
T-cell recognition of melanoma antigens and its therapeutic applications. (9266280)
1997
42
Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors. (8832418)
1996
43
Blood-ocular barrier breakdown in eyes with ocular melanoma. A potential role for vascular endothelial growth factor/vascular permeability factor. (7485392)
1995
44
Immunohistochemical analysis of Bcl-2 protein regulation in cutaneous melanoma. (7534042)
1995
45
Phenotype of glutathione S-transferase Mu (GSTM1) and susceptibility to malignant melanoma. MMM group. Multidisciplinary Malignant Melanoma Group. (7640212)
1995
46
In vitro sensitivity of human melanoma cells to chemotherapeutic agents and interferons. (7524835)
1994
47
MUC18, a melanoma-progression associated molecule, and its potential role in tumor vascularization and hematogenous spread. (7923217)
1994
48
Isolation of naturally processed peptides recognized by cytolytic T lymphocytes (CTL) on human melanoma cells in association with HLA-A2.1. (8169004)
1994
49
CEA immunoreactivity in metastatic malignant melanoma. (1495947)
1992
50
Plasmodium falciparum: the effect of pH and Ca2+ concentration on the in vitro cytoadherence of infected erythrocytes to amelanotic melanoma cells. (1915750)
1991

Genetic Variations for Melanoma

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Expression for genes affiliated with Melanoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Melanoma

Search GEO for disease gene expression data for Melanoma.

Pathways for genes affiliated with Melanoma

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Compounds for genes affiliated with Melanoma

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44Novoseek
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Compounds related to Melanoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hemocyanin4410.9MAGEA3, PMEL

GO Terms for genes affiliated with Melanoma

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16Gene Ontology
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Biological processes related to Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanin biosynthetic processGO:04243810.9SLC45A2, PMEL

Products for genes affiliated with Melanoma

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Sources for Melanoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet