MCID: MLN045
MIFTS: 36

Melanoma of Soft Part malady

Cancer diseases, Muscle diseases categories

Summaries for Melanoma of Soft Part

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MalaCards: Melanoma of Soft Part, also known as clear cell sarcoma of the tendons and aponeuroses, is related to melanoma and clear cell sarcoma. An important gene associated with Melanoma of Soft Part is ATF1 (activating transcription factor 1), and among its related pathways are RSK activation and TOB in Osteoblast Signaling. The compounds pge2 and ciprofibrate have been mentioned in the context of this disorder. Related mouse phenotypes are pigmentation and embryogenesis.

Aliases & Classifications for Melanoma of Soft Part

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48Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Muscle diseases


Aliases & Descriptions:

melanoma of soft part 48
clear cell sarcoma of the tendons and aponeuroses 48
clear cell sarcoma of soft tissue 48


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SNOMED-CT via Orphanet57 402561003

Related Diseases for Melanoma of Soft Part

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17GeneCards, 18GeneDecks
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Diseases related to Melanoma of Soft Part via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma31.3BRAF, EWSR1, FLI1, ERBB3, MYC, NRG1
2clear cell sarcoma31.3BRAF, EWSR1, CREB1, ATF1, ERBB3
3sarcoma31.3ERBB3, BRAF, FLI1, EWSR1, MLANA, ATF1
4synovial sarcoma30.7FLI1, EWSR1
5epithelioid cell synovial sarcoma10.5
6arthritis10.5
7epithelioid sarcoma10.5
8ovary sarcoma10.3
9familial melanoma10.2
10lung sarcoma10.2
11pericardial effusion10.2
12nephroblastoma10.0EWSR1
13myoepithelioma10.0EWSR1
14angiosarcoma10.0FLI1
15leydig cell tumor10.0CREB1
16perivascular epithelioid cell tumor10.0MLANA
17neuroblastoma10.0MYC
18hemangioma10.0FLI1
19myxoid liposarcoma10.0ATF1, EWSR1
20gastrointestinal stromal tumor10.0DES
21endometriosis10.0FGF9
22glomus tumor10.0DES
23cerebral primitive neuroectodermal tumor10.0FLI1, EWSR1
24teratocarcinoma10.0CREB1
25desmoplastic small round cell tumor10.0EWSR1, DES
26connective tissue benign neoplasm10.0EWSR1, FLI1
27angiomyolipoma10.0DES, MLANA
28fibrous histiocytoma10.0DES, ATF1
29embryonal rhabdomyosarcoma10.0EWSR1, DES
30leiomyosarcoma10.0MLANA, DES
31uterine sarcoma10.0DES
32seminoma10.0BRAF
33thyroid cancer10.0BRAF
34childhood medulloblastoma10.0ERBB3, MYC
35astrocytoma10.0ERBB3, NRG1
36lung cancer10.0MYC, ERBB3
37neurofibromatosis10.0CREB1
38liposarcoma10.0EWSR1, DES, FLI1
39sertoli cell tumor10.0DES
40rubinstein-taybi syndrome10.0CREB1, CREBBP
41neuroepithelioma10.0MYC, FLI1, EWSR1
42peripheral primitive neuroectodermal tumor10.0FLI1, DES, EWSR1, ATF1
43acute leukemia10.0CREB1, EWSR1, CREBBP
44rhabdomyosarcoma10.0ERBB3, FLI1, DES, EWSR1
45choriocarcinoma10.0ERBB3, CREB1, CREBBP
46breast cancer10.0ERBB3, NRG1, MYC
47acute erythroid leukemia10.0FLI1, CREB1, MYC
48squamous cell carcinoma of the head and neck10.0MYC, NRG1, ERBB3
49myeloid leukemia10.0MYC, CREBBP, CREB1
50hepatocellular carcinoma10.0CREB1, ATF1, MYC, ERBB3

Graphical network of the top 20 diseases related to Melanoma of Soft Part:



Diseases related to melanoma of soft part

Clinical Features for Melanoma of Soft Part

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Drugs & Therapeutics for Melanoma of Soft Part

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Melanoma of Soft Part

Drug clinical trials:

Search ClinicalTrials for Melanoma of Soft Part

Search NIH Clinical Center for Melanoma of Soft Part

Search CenterWatch for Melanoma of Soft Part

Genetic Tests for Melanoma of Soft Part

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Anatomical Context for Melanoma of Soft Part

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Animal Models for Melanoma of Soft Part or affiliated genes

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36MGI
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Publications for Melanoma of Soft Part

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Genetic Variations for Melanoma of Soft Part

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Expression for genes affiliated with Melanoma of Soft Part

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Melanoma of Soft Part

Search GEO for disease gene expression data for Melanoma of Soft Part.

Pathways for genes affiliated with Melanoma of Soft Part

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Sources:
53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 52R&D Systems, 49PharmGKB
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Pathways related to Melanoma of Soft Part according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9CREB1, ATF1
29.7CREB1, CREBBP
39.7BRAF, CREB1
49.5MYC, BRAF
5
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9.5NRG1, ERBB3
69.5NRG1, ERBB3
79.5MYC, ATF1, CREB1
89.4BRAF, CREB1, ATF1
9
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9.4BRAF, CREB1, ATF1
10
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9.3MYC, CREB1, CREBBP
119.3MYC, CREB1, CREBBP
129.3MYC, CREB1, CREBBP
13
Development Prolactin receptor signaling
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9.3MYC, CREB1, CREBBP
149.2MYC, CREB1, BRAF
15
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9.2BRAF, CREBBP, CREB1
16
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9.2CREB1, CREBBP, BRAF
17
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9.0CREBBP, CREB1, ATF1, MYC
189.0CREBBP, CREB1, ATF1, MYC
199.0EWSR1, FLI1, ATF1, MYC
209.0MYC, ATF1, CREB1, BRAF
21
Hide members
9.0MYC, ATF1, CREB1, BRAF
229.0MYC, ATF1, CREB1, BRAF
239.0MYC, ATF1, CREB1, BRAF
24
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8.9ERBB3, FGF9, NRG1, CREB1
25
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8.9CREB1, NRG1, FGF9, ERBB3
26
Hide members
8.9CREB1, NRG1, FGF9, ERBB3
278.9ERBB3, FGF9, MYC, BRAF
28
Hide members
8.9BRAF, CREBBP, CREB1, ERBB3
29
Hide members
8.8MYC, CREB1, CREBBP, BRAF
30
Hide members
8.8BRAF, CREBBP, CREB1, MYC
318.8FGF9, MYC, CREBBP, BRAF
32
Development Ligand-independent activation of ESR1 and ESR2
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8.8CREBBP, CREB1, NRG1, ERBB3
33
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8.8CREBBP, CREB1, NRG1, ERBB3
34
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8.6BRAF, NRG1, MYC, ERBB3
35
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8.6BRAF, CREBBP, CREB1, NRG1
36
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8.5ERBB3, NRG1, CREBBP, BRAF
37
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8.5CREBBP, CREB1, ATF1, NRG1, FGF9
38
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8.4BRAF, CREBBP, CREB1, MYC, ERBB3
39
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8.3BRAF, CREB1, NRG1, MYC, ERBB3
40
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8.1BRAF, CREBBP, CREB1, MYC, FGF9, ERBB3
41
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8.1BRAF, CREB1, ATF1, NRG1, FGF9, ERBB3
428.0CREBBP, CREB1, NRG1, MYC, FGF9, ERBB3
43
Hide members
8.0BRAF, CREBBP, CREB1, ATF1, NRG1, ERBB3
44
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7.8BRAF, CREBBP, CREB1, NRG1, MYC, ERBB3
45
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7.8BRAF, CREBBP, CREB1, NRG1, MYC, ERBB3
46
Hide members
7.6ERBB3, BRAF, CREBBP, CREB1, ATF1, NRG1
47
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7.5BRAF, CREBBP, CREB1, NRG1, MYC, FGF9
48
Hide members
7.5BRAF, CREBBP, CREB1, NRG1, MYC, FGF9
49
Hide members
7.2MYC, NRG1, ATF1, CREB1, CREBBP, BRAF
50
Hide members
7.2BRAF, CREBBP, CREB1, ATF1, DES, NRG1

Compounds for genes affiliated with Melanoma of Soft Part

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Melanoma of Soft Part according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1pge24410.4ATF1
2ciprofibrate44 2810.8CREBBP, MYC
3hrgbeta1449.5ERBB3, MYC, NRG1
4p002449.5BRAF, DES, ERBB3
5adriamycin449.5MYC, DES, CREBBP
6okadaic acid44 5910.4CREBBP, CREB1, ATF1, MYC
7carbachol44 28 1111.4CREB1, NRG1, ERBB3
84-hydroxytamoxifen449.3CREBBP, NRG1, MYC
9estradiol44 11 2411.3ERBB3, DES, CREB1, CREBBP
10paclitaxel44 49 1111.2MYC, NRG1, BRAF
11bromodeoxyuridine449.2DES, NRG1, MYC
12lapatinib44 49 1111.2ERBB3, NRG1
13isoproterenol44 1110.2CREB1, CREBBP, BRAF
14acetylcholine44 49 28 11 2413.1CREB1, DES, NRG1, ERBB3
15imatinib44 49 1111.1BRAF, DES, MYC
16actinomycin d449.1CREB1, DES, NRG1, MYC
17etoposide44 49 59 1112.0CREBBP, CREB1, NRG1, MYC
18wortmannin449.0ERBB3, NRG1, CREB1, BRAF
19tamoxifen44 49 28 1112.0ERBB3, MYC, NRG1, CREBBP
20leucine448.9CREB1, ATF1, NRG1, MYC
21fatty acid448.9ERBB3, NRG1, CREBBP, BRAF
22glucose448.9ERBB3, NRG1, CREBBP, BRAF
23heparin44 28 11 2411.8ERBB3, FGF9, NRG1, DES
24phosphoinositide448.8BRAF, CREB1, ATF1, NRG1, ERBB3
25testosterone44 59 11 2411.7CREBBP, CREB1, DES, NRG1, ERBB3
26agar448.7BRAF, CREB1, NRG1, MYC, ERBB3
27rapamycin448.7BRAF, CREB1, NRG1, MYC, ERBB3
28ly294002448.7ERBB3, MYC, NRG1, CREB1, BRAF
29doxorubicin44 49 1110.7CREBBP, DES, NRG1, MYC, ERBB3
30cisplatin44 49 59 1111.6MYC, NRG1, CREBBP, BRAF
3112-o-tetradecanoylphorbol 13-acetate448.4BRAF, CREB1, ATF1, DES, NRG1, MYC
32alanine448.4BRAF, CREBBP, NRG1, MYC, ERBB3
33forskolin44 49 1110.4BRAF, CREBBP, CREB1, ATF1, NRG1, ERBB3
34pd 98,059448.3BRAF, CREBBP, CREB1, ATF1, NRG1, MYC
35progesterone44 59 28 11 2412.3BRAF, CREBBP, ATF1, DES, NRG1, ERBB3
36phosphatidylinositol448.2BRAF, CREBBP, CREB1, NRG1, MYC, ERBB3
37cyclic amp44 249.1BRAF, EWSR1, CREBBP, CREB1, ATF1, DES
38retinoic acid44 248.9BRAF, EWSR1, CREBBP, CREB1, DES, NRG1
39threonine447.9BRAF, CREBBP, CREB1, DES, NRG1, MYC
40steroid447.7CREBBP, CREB1, MLANA, ATF1, DES, NRG1
41oligonucleotide447.6BRAF, EWSR1, CREB1, FLI1, ATF1, NRG1
42vegf447.6BRAF, CREBBP, CREB1, DES, NRG1, MYC
43paraffin447.5BRAF, EWSR1, MLANA, DES, NRG1, MYC
44calcium44 49 11 2410.4BRAF, EWSR1, CREBBP, CREB1, ATF1, DES
45tyrosine447.3BRAF, EWSR1, CREBBP, CREB1, DES, NRG1
46serine446.8ERBB3, BRAF, EWSR1, CREBBP, CREB1, FLI1

GO Terms for genes affiliated with Melanoma of Soft Part

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16Gene Ontology
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Cellular components related to Melanoma of Soft Part according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.5ATF1, CREB1, CREBBP

Biological processes related to Melanoma of Soft Part according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of secretionGO:0510489.6ERBB3, NRG1
2positive regulation of cardiac muscle cell proliferationGO:0600459.5FGF9, NRG1
3Notch signaling pathwayGO:0072199.2MYC, CREB1, CREBBP
4positive regulation of protein tyrosine kinase activityGO:0610989.2ERBB3, NRG1
5phosphatidylinositol-mediated signalingGO:0480159.0CREB1, NRG1, FGF9, ERBB3
6Fc-epsilon receptor signaling pathwayGO:0380959.0CREB1, NRG1, FGF9, ERBB3
7epidermal growth factor receptor signaling pathwayGO:0071738.9CREB1, NRG1, FGF9, ERBB3
8fibroblast growth factor receptor signaling pathwayGO:0085438.6BRAF, CREB1, NRG1, FGF9, ERBB3
9innate immune responseGO:0450878.3CREBBP, CREB1, ATF1, NRG1, FGF9, ERBB3
10neurotrophin TRK receptor signaling pathwayGO:0480118.3ERBB3, FGF9, NRG1, ATF1, CREB1, BRAF

Molecular functions related to Melanoma of Soft Part according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activator activityGO:0302969.5NRG1, ERBB3
2RNA polymerase II distal enhancer sequence-specific DNA bindingGO:0009809.4CREB1, FLI1
3identical protein bindingGO:0428029.0ERBB3, DES, EWSR1, BRAF
4sequence-specific DNA binding transcription factor activityGO:0037008.4MYC, ATF1, FLI1, CREB1, CREBBP
5protein bindingGO:0055156.1ERBB3, BRAF, EWSR1, CREBBP, CREB1, MLANA

Products for genes affiliated with Melanoma of Soft Part

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Sources for Melanoma of Soft Part

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet