Melanoma of Soft Tissue

Categories: Rare diseases, Skin diseases, Muscle diseases, Cancer diseases

Aliases & Classifications for Melanoma of Soft Tissue

MalaCards integrated aliases for Melanoma of Soft Tissue:

Name: Melanoma of Soft Tissue 56
Clear Cell Sarcoma of the Tendons and Aponeuroses 56


External Ids:

Orphanet 56 ORPHA97338
UMLS via Orphanet 70 C0206651

Summaries for Melanoma of Soft Tissue

MalaCards based summary : Melanoma of Soft Tissue, also known as clear cell sarcoma of the tendons and aponeuroses, is related to clear cell sarcoma and melanoma. An important gene associated with Melanoma of Soft Tissue is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways are Myometrial Relaxation and Contraction Pathways and HTLV-I infection. The drugs Cyclophosphamide and Morphine have been mentioned in the context of this disorder. Affiliated tissues include t cells, liver and testes.

Wikipedia : 72 Clear-cell sarcoma (formerly known as malignant melanoma of the soft parts) is a rare form of cancer... more...

Related Diseases for Melanoma of Soft Tissue

Diseases related to Melanoma of Soft Tissue via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
id Related Disease Score Top Affiliating Genes
1 clear cell sarcoma 11.4
2 melanoma 10.0
3 sarcoma 9.9
4 kala-azar 1 9.7 ATF1 EWSR1
5 hunter carpenter macdonald syndrome 9.5 ATF1 CREB1
6 vitamin d-dependent rickets, type i 9.4 ATF1 EWSR1
7 necatoriasis 9.3 CREB1 EWSR1
8 parkinsonism with dementia of guadeloupe 9.1 ATF1 CREB1 EWSR1
9 kidney sarcoma 9.0 ATF1 CREB1 EWSR1
10 malignant adenofibroma 9.0 ATF1 CREB1 EWSR1
11 spindle cell sarcoma 8.9 ATF1 CREB1 EWSR1

Graphical network of the top 20 diseases related to Melanoma of Soft Tissue:

Diseases related to Melanoma of Soft Tissue

Symptoms & Phenotypes for Melanoma of Soft Tissue

Drugs & Therapeutics for Melanoma of Soft Tissue

Drugs for Melanoma of Soft Tissue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 141)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Cyclophosphamide Approved, Investigational Phase 3,Phase 1,Phase 2 50-18-0, 6055-19-2 2907
Morphine Approved, Investigational Phase 3 57-27-2 5288826
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
5 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
6 Liver Extracts Phase 3,Phase 1,Phase 2,Early Phase 1
7 Interleukin-2 Phase 3,Phase 2,Phase 1
8 Epoetin alfa Phase 3 113427-24-0
9 Analgesics Phase 3,Phase 2,Phase 1
10 Central Nervous System Depressants Phase 3
11 Adjuvants, Anesthesia Phase 3
12 Narcotics Phase 3
13 Analgesics, Non-Narcotic Phase 3,Phase 2,Phase 1
14 Analgesics, Opioid Phase 3
15 Anesthetics Phase 3
16 Anesthetics, General Phase 3
17 Anesthetics, Intravenous Phase 3
18 Vaccines Phase 3,Phase 1,Phase 2
19 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
20 Cola Nutraceutical Phase 3,Phase 1,Early Phase 1
Doxorubicin Approved, Investigational Phase 1, Phase 2 23214-92-8 31703
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
Melphalan Approved Phase 2,Phase 1 148-82-3 4053 460612
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
Dactinomycin Approved Phase 2 50-76-0 2019 457193
Dabrafenib Approved Phase 1, Phase 2 44462760 44516822
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
Trametinib Approved Phase 1, Phase 2 871700-17-3 11707110
nivolumab Approved Phase 1, Phase 2 946414-94-4
Edetic Acid Approved, Vet_approved Phase 2 60-00-4, 62-33-9 6049
Trabectedin Approved, Investigational Phase 1, Phase 2 114899-77-3 108150
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
Acetaminophen Approved Phase 2 103-90-2 1983
Diphenhydramine Approved Phase 2 58-73-1, 147-24-0 3100
Leuprolide Approved, Investigational Phase 2 53714-56-0 3911 657181
Promethazine Approved Phase 2 60-87-7 4927
Propranolol Approved, Investigational Phase 1, Phase 2 525-66-6 4946
Iodine Investigational Phase 2,Phase 1 7553-56-2 807
Doxil Approved June 1999 Phase 1, Phase 2 31703
40 Alkylating Agents Phase 2,Phase 1
41 Immunosuppressive Agents Phase 2,Phase 1
42 cadexomer iodine Phase 2,Phase 1
43 Albumin-Bound Paclitaxel Phase 1, Phase 2
44 Topoisomerase Inhibitors Phase 1, Phase 2
45 Nucleic Acid Synthesis Inhibitors Phase 2
46 Anti-Bacterial Agents Phase 2,Phase 1
47 Anti-HIV Agents Phase 2
48 Anti-Infective Agents Phase 2,Phase 1
49 Immunoglobulins Phase 2,Phase 1
50 Antibodies, Monoclonal Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 85)

id Name Status NCT ID Phase Drugs
1 Cryoablation or External-Beam Radiation Therapy in Treating Patients With Painful Bone Metastases Completed NCT00540969 Phase 3
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 E-MOSAIC Electronic Tool to Monitor Symptoms Completed NCT00477919 Phase 3
4 An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation Completed NCT00132704 Phase 3
5 Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy Active, not recruiting NCT01223248 Phase 3
6 M-Vax + Low Dose Interleukin-2 Versus Placebo Vaccine in Metastatic Melanoma in Patients With Stage IV Melanoma Not yet recruiting NCT00477906 Phase 3
7 Intralesional Treatment With Interleukin-2 (Proleukin) in Soft Tissue Melanoma Metastases Completed NCT00204581 Phase 2 Interleukin-2 (Proleukin)
8 Isolated Limb Infusion of Chemotherapy in Treating Patients With Melanoma or Soft Tissue Sarcoma of the Arm or Leg That Cannot Be Removed By Surgery Completed NCT00004250 Phase 2 isolated limb perfusion;melphalan
9 A Phase II Study to Evaluate Safety and Efficacy of Combined Treatment With Ipilimumab and Intratumoral Interleukin-2 Completed NCT01480323 Phase 2 Interleukin-2;Ipilimumab
10 Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma Completed NCT00003308 Phase 2
11 Intratumoral Application of L19IL2 in Patients With Malignant Melanoma Completed NCT01253096 Phase 2 Intratumoral injections of L19IL2
12 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
13 Magnetic-Targeted Doxorubicin in Treating Patients With Cancer Metastatic to the Liver Completed NCT00041808 Phase 1, Phase 2 MTC-DOX for Injection
14 Radiotherapy & Combi in Metastatic Melanoma Recruiting NCT02392871 Phase 1, Phase 2 Dabrafenib and trametinib (combination)
15 Trabectedin, Ipilimumab and Nivolumab as First Line Treatment for Advanced Soft Tissue Sarcoma Recruiting NCT03138161 Phase 1, Phase 2 Trabectedin;Ipilimumab;Nivolumab
16 A Study Comparing Lymphoseek® and Vital Blue Dye as Lymphoid Tissue Targeting Agents in Pediatric Patients With Melanoma, Rhabdomyosarcoma, or Other Solid Tumors Who Are Undergoing Lymph Node Mapping Recruiting NCT02509598 Phase 2 Tc99m tilmanocept;Vital Blue Dye
17 Induction Therapy With Vemurafenib and Cobimetinib to Optimize Nivolumab and Ipilimumab Therapy Recruiting NCT02968303 Phase 2 Vemurafenib and Cobimetinib
18 Study of Neoadjuvant Checkpoint Blockade in Patients With Surgically Resectable Undifferentiated Pleomorphic Sarcoma and Dedifferentiated Liposarcoma Recruiting NCT03307616 Phase 2 Nivolumab;Ipilimumab
19 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
20 Salvage Radiotherapy Combined With Hormonotherapy in Oligometastatic Pelvic Node Relapses of Prostate Cancer Active, not recruiting NCT02274779 Phase 2 ELIGARD
21 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
22 To Find a Safe Dose and Show Early Clinical Activity of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent/ Refractory Solid Tumors Active, not recruiting NCT01962103 Phase 1, Phase 2 nab-paclitaxel
23 A Combination Clinical Study of PLX3397 and Pembrolizumab To Treat Advanced Melanoma and Other Solid Tumors Active, not recruiting NCT02452424 Phase 1, Phase 2 PLX3397
24 Dose-Finding of Propranolol in Combination With Metronomic Fixed Oral Cyclophosphamide Based on Bivariate Efficacy-tolerability Outcome in Patients With Locally Advanced or Metastatic Angiosarcoma: A Collaborative and Innovative Phase I-II Sequential Tria Not yet recruiting NCT02732678 Phase 1, Phase 2 PROPRANOLOL
25 Study of 18F-Fluorodeoxyglucose (FluGlucoScan) in Patients With Known or Suspected Soft Tissue Sarcoma Terminated NCT00123786 Phase 2
26 Conformal Radiation Therapy in Treating Patients With Metastatic Cancer Outside the Brain Terminated NCT00550654 Phase 2
27 HYPAZ: Hypertension Induced by Pazopanib Terminated NCT01392352 Phase 2 Pazopanib
28 SARC029: Trametinib and Pazopanib in Patients With GIST (Gastrointestinal Stromal Tumor) Withdrawn NCT02342600 Phase 2 Pazopanib;Trametinib
29 Experimental Therapeutic Cancer Vaccine Created In-situ in Patients With Stage II-Stage IV Cancer Withdrawn NCT01065441 Phase 1, Phase 2
30 Safety Study of Dacarbazine and Bortezomib in Melanoma and Soft Tissue Sarcoma Completed NCT00580320 Phase 1 Dacarbazine and bortezomib
31 Phase I Study of Docetaxel and Temsirolimus in Resistant Solid Malignancies Completed NCT00703625 Phase 1 Temsirolimus;Docetaxel
32 Vaccine Therapy in Treating Patients With Metastatic Cancer Completed NCT00020267 Phase 1 interleukin-2;MAGE-12 peptide vaccine;Montanide ISA-51
33 Phase I Study of DOXIL and Temsirolimus in Resistant Solid Malignancies Completed NCT00703170 Phase 1 Temsirolimus;Pegylated liposomal doxorubicin
34 Biological Therapy in Treating Children With Refractory or Recurrent Neuroblastoma or Other Tumors Completed NCT00003750 Phase 1
35 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
36 Tumor Cell Vaccine for Patients Undergoing Surgery for Sarcomas, Melanomas, Germ Cell Tumors, or Malignancies That Have Metastasized to the Lungs, Pleura, or Mediastinum Completed NCT01313429 Phase 1 Cyclophosphamide;Celecoxib
37 Combination Chemotherapy Plus Filgrastim in Treating Patients With Advanced Solid Tumors Completed NCT00014456 Phase 1 docetaxel;gemcitabine hydrochloride
38 A Phase I Trial Of The Humanized Anti-GD2 Antibody In Children And Adolescents With Neuroblastoma, Osteosarcoma, Ewing Sarcoma and Melanoma Completed NCT00743496 Phase 1
39 Pilot Study of a Double Isolation Perfusion Schedule Using Melphalan Alone for Intransit Melanoma or Unresectable Sarcoma of the Extremity Completed NCT00001577 Phase 1
40 A Phase 1 Trial of NY-ESO-1 With GLA-SE in Patients With Unresectable or Metastatic Cancer Completed NCT02015416 Phase 1
41 Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer. Completed NCT00423254 Phase 1
42 Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor Completed NCT00161187 Phase 1
43 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
44 High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Cancer Completed NCT00002854 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;mesna;paclitaxel
45 Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas Completed NCT00101270 Phase 1 irinotecan hydrochloride;oxaliplatin
46 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
47 Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors Completed NCT00003597 Phase 1 carboplatin;etoposide;ifosfamide
48 Use of Racotumomab in Patients With Pediatric Tumors Expressing N-glycolylated Gangliosides Completed NCT01598454 Phase 1 racotumomab
49 A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors Completed NCT02107963 Phase 1 AP1903;Cyclophosphamide
50 To Evaluate the Efficacy of NY-ESO-1-specific T Cell Receptor (TCR) Affinity Enhancing Specific T Cell in Solid Tumors Recruiting NCT03159585 Phase 1 Cyclophosphamide

Search NIH Clinical Center for Melanoma of Soft Tissue

Genetic Tests for Melanoma of Soft Tissue

Anatomical Context for Melanoma of Soft Tissue

MalaCards organs/tissues related to Melanoma of Soft Tissue:

T Cells, Liver, Testes, Brain, Lung, Endothelial, Lymph Node

Publications for Melanoma of Soft Tissue

Articles related to Melanoma of Soft Tissue:

id Title Authors Year
Lessons to be learned: a case study approach. Malignant melanoma of soft tissue. ( 15712852 )
Malignant melanoma of soft tissues (clear cell sarcoma) of the foot. Is MRI able to perform a specific diagnosis? Report of one case and review of the radiological literature. ( 11268490 )
Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft tissue). A case report. ( 2149419 )
Clear cell sarcoma of tendons and aponeuroses: malignant melanoma of soft tissues? Report of four cases. ( 556273 )

Variations for Melanoma of Soft Tissue

Expression for Melanoma of Soft Tissue

Search GEO for disease gene expression data for Melanoma of Soft Tissue.

Pathways for Melanoma of Soft Tissue

GO Terms for Melanoma of Soft Tissue

Cellular components related to Melanoma of Soft Tissue according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.62 ATF1 CREB1

Molecular functions related to Melanoma of Soft Tissue according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 8.62 ATF1 CREB1

Sources for Melanoma of Soft Tissue

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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