MCID: MLD001
MIFTS: 65

Melioidosis malady

Infectious diseases, Immune diseases categories

Summaries for Melioidosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection, has material basis in burkholderia pseudomallei, which is transmitted by contact with the contaminated water or soil. the infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.

MalaCards: Melioidosis, also known as acute and fulminating melioidosis, is related to pneumonia and tuberculosis, and has symptoms including stomach pain, chest pain and respiratory distress. An important gene associated with Melioidosis is TLR4 (toll-like receptor 4), and among its related pathways are MIF Action Through Endocytic Pathway and MSP-RON Signaling. The compounds gm-csf and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and skin, and related mouse phenotypes are tumorigenesis and liver/biliary system.

CDC:3 Melioidosis, also called Whitmore's disease, is an infectious disease that can infect humans or animals. The disease is caused by the bacterium Burkholderia pseudomallei.

Wikipedia:63 Melioidosis is an infectious disease caused by a Gram-negative bacterium, Burkholderia pseudomallei,... more...

Aliases & Classifications for Melioidosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Immune diseases


Aliases & Descriptions:

melioidosis 8 10 44 60
acute and fulminating melioidosis 8
subacute and chronic melioidosis 8
nightcliff gardener's disease 8
melioidosis, unspecified 8
epizootic lymphangitis 60
whitmore's disease 8
pseudoglanders 8


External Ids:

Disease Ontology8 DOID:5052
ICD9CM27 025
MeSH34 D008554

Related Diseases for Melioidosis

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17GeneCards, 18GeneDecks
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Diseases related to Melioidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.5TLR4, TLR2, TLR5, CSF3, IL10, TREM1
2tuberculosis30.4IL18, IL10, CXCL9, CXCR3, MIF, TREM1
3arthritis30.3IL18, IL10, CXCL9, CXCR3, MIF, TLR2
4cystic fibrosis30.0TLR4
5hepatitis30.0TLR2, IL18
6pulmonary tuberculosis30.0TLR2, IL18, IL10
7bronchiolitis29.8TLR4
8meningitis29.8TLR2
9bronchiolitis obliterans29.8CXCR3
10neutropenia29.8CSF3
11pancreatitis29.8IL10
12peritonitis29.8TLR2, IL15
13lupus erythematosus29.8F5, IL18
14leukemia29.7TLR2, TLR4, CXCR3, IL15, PLAUR, CSF3
15systemic lupus erythematosus29.7TLR2, TLR4, TLR5, IL18, CXCR3, IL10
16lymphangitis10.8
17histoplasmosis10.6
18glanders10.5
19melioidosis, susceptibilty to10.4
20splenic abscess10.3
21osteomyelitis10.2
22leptospirosis10.2
23septic arthritis10.2
24prostatitis10.2
25cellulitis10.1
26cerebritis10.1
27necrotizing fasciitis10.1
28fasciitis10.1
29orbital cellulitis10.0
30aortic aneurysm10.0
31mediastinitis10.0
32pericardial effusion10.0
33pericarditis10.0
34leprosy10.0TLR2
35measles10.0TLR2
36otitis media10.0TLR2
37herpes simplex10.0TLR2
38viral hepatitis10.0TLR2
39acute myocardial infarction10.0MIF
40pulmonary fibrosis10.0CXCR3
41skin disease10.0CXCL9
42visceral leishmaniasis10.0FAM120B
43aspergillosis10.0TLR4, TLR2
44graves' disease10.0CXCR3
45encephalitis10.0TLR2, CXCL9
46multiple myeloma10.0CSF3
47adenocarcinoma10.0PLAUR
48infertility10.0MIF
49filariasis10.0TLR2, TLR4
50celiac disease10.0IL15

Graphical network of the top 20 diseases related to Melioidosis:



Diseases related to melioidosis

Clinical Features for Melioidosis

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8Disease Ontology
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Symptoms:

8
  • stomach pain
  • chest pain
  • respiratory distress
  • fever

Drugs & Therapeutics for Melioidosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Melioidosis

Drug clinical trials:

Search ClinicalTrials for Melioidosis

Search NIH Clinical Center for Melioidosis

Search CenterWatch for Melioidosis

Genetic Tests for Melioidosis

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Anatomical Context for Melioidosis

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32MalaCards
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MalaCards organs/tissues related to Melioidosis:

32
Bone, Lung, Skin, Testes, Liver, Prostate, T cells, Whole blood, Breast, Myeloid, Monocytes, Endothelial, Kidney, Spinal cord, Brain, Spleen

Animal Models for Melioidosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Melioidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.4TREM1, MIF, CXCR3, IL10
2MP:00053709.2TLR2, TLR5, F5, IL10, PLAUR, TLR4
3MP:00053858.4TLR4, TLR2, TLR5, F5, CXCR3, IL15
4MP:00053848.1TLR4, TLR2, TLR5, TREM1, MIF, CXCR3
5MP:00053768.0TLR4, TLR2, TLR5, F5, TREM1, MIF
6MP:00053977.7TLR4, TLR2, TLR5, CSF3, IRAK3, TREM1
7MP:00053877.1PLAUR, TLR4, TLR2, TLR5, TLR1, CSF3

Publications for Melioidosis

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50PubMed
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Articles related to Melioidosis:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Mice Lacking the Lectin-Like Domain of Thrombomodulin Are Protected Against Melioidosis. (24399241)
2014
2
Environmental management procedures following fatal melioidosis in a captive chimpanzee (Pan troglodytes). (23805570)
2013
3
Screen of whole blood responses to flagellin identifies TLR5 variation associated with outcome in melioidosis. (24285178)
2013
4
Endogenous I+2-antiplasmin is protective during severe gram-negative sepsis (melioidosis). (23992406)
2013
5
Deficiency of protease-activated receptor-1 limits bacterial dissemination during severe Gram-negative sepsis (melioidosis). (24239704)
2013
6
Melioidosis in a returning traveller. (23605844)
2013
7
Impaired early cytokine responses at the site of infection in a murine model of type 2 diabetes and melioidosis comorbidity. (23208607)
2013
8
Melioidosis with a Pericardial Effusion, which Relapsed as a Chest Wall Abscess: A Rare Presentation. (23730667)
2013
9
Host responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling. (23383015)
2013
10
Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis). (23216621)
2013
11
Neonatal melioidosis: systematic review of the literature. (22739573)
2012
12
Burkholderia pseudomallei triggers altered inflammatory profiles in a whole-blood model of type 2 diabetes-melioidosis comorbidity. (22473609)
2012
13
Out of the ground: aerial and exotic habitats of the melioidosis bacterium Burkholderia pseudomallei in grasses in Australia. (22176696)
2012
14
A non-invasive intratracheal inoculation method for the study of pulmonary melioidosis. (23267442)
2012
15
Comparison of TaqMan PCR assays for detection of the melioidosis agent Burkholderia pseudomallei in clinical specimens. (22442327)
2012
16
Cranial melioidosis with extradural extension after a fall in the bathroom. (23024720)
2012
17
Epidemiology and investigation of melioidosis, Southern Arizona. (21762589)
2011
18
Melioidosis acquired by traveler to Nigeria. (21762592)
2011
19
Neutrophils are the predominant cell-type to associate with Burkholderia pseudomallei in a BALB/c mouse model of respiratory melioidosis. (21798336)
2011
20
Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis. (21633019)
2011
21
Burkholderia thailandensis whole cell antigen cross-reacts with B. pseudomallei antibodies from patients with melioidosis in an immunofluorescent assay. (20578523)
2010
22
Evaluation of azithromycin, trovafloxacin and grepafloxacin as prophylaxis for experimental murine melioidosis. (20462743)
2010
23
Melioidosis pericarditis mimicking tuberculous pericarditis. (20645861)
2010
24
Computerized tomographic findings of hepatic fascioliasis compared with melioidosis-caused liver abscesses. (20649065)
2010
25
Melioidosis in a tropical city state, Singapore. (19861063)
2009
26
Dosing regimens of cotrimoxazole (trimethoprim-sulfamethoxazole) for melioidosis. (19620336)
2009
27
CT findings of liver and splenic abscesses in melioidosis: comparison with those in non-melioidosis. (19938740)
2009
28
Rheumatological manifestations in patients with melioidosis. (19058601)
2008
29
Evaluation of recombinant antigens for diagnosis of melioidosis. (18657105)
2008
30
Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis. (17362501)
2007
31
Melioidosis presenting as genitourinary infection in two men with diabetes. (17495376)
2007
32
Paediatric melioidosis with septic shock in a previously-well child. (17384864)
2007
33
Melioidosis complicated by pericarditis. (17454903)
2007
34
Endogenous interleukin-18 improves the early antimicrobial host response in severe melioidosis. (17517876)
2007
35
Dural sinus thrombosis in melioidosis: the first case report. (16579013)
2006
36
Stent-graft for recurrent melioidosis mycotic aortic aneurysm. (16551809)
2006
37
Global map of growth-regulated gene expression in Burkholderia pseudomallei, the causative agent of melioidosis. (16997946)
2006
38
Extreme weather events and environmental contamination are associated with case-clusters of melioidosis in the Northern Territory of Australia. (16326823)
2006
39
Melioidosis with endophthalmitis. (17030726)
2006
40
Melioidosis in Pahang, Malaysia. (16515112)
2005
41
Melioidosis: an emerging infectious disease. (16006713)
2005
42
Melioidosis; the remarkable imitator: recent perspectives. (15656034)
2004
43
Further evaluation of a rapid diagnostic test for melioidosis in an area of endemicity. (15131200)
2004
44
Other bacterial diseases as a potential consequence of bioterrorism: Q fever, brucellosis, glanders, and melioidosis. (12833721)
2003
45
Melioidosis presenting as an infected intrathoracic subclavian artery pseudoaneurysm treated with femoral vein interposition graft. (11877708)
2002
46
Melioidosis in the Torres Strait islands of far North Queensland. (12206383)
2002
47
Cerebral melioidosis in Singapore: a review of five cases. (11926000)
2002
48
Demonstration of a cell-mediated immune response in melioidosis. (12134268)
2002
49
Reactivation of latent melioidosis in association with staphylococcal endocarditis. (11480478)
2001
50
Fulminant septic melioidosis after a vacation in Thailand. (11244616)
2000

Genetic Variations for Melioidosis

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Expression for genes affiliated with Melioidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Melioidosis

Search GEO for disease gene expression data for Melioidosis.

Pathways for genes affiliated with Melioidosis

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology, 53Reactome, 52R&D Systems, 59Tocris Bioscience, 55SinoBiological, 37NCBI BioSystems Database
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Pathways related to Melioidosis according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1MIF, TLR4
29.9IL18, TLR2, TLR4
39.9TLR4, TLR5, IL18
4
Hide members
9.9TLR4, IRAK3, MIF
59.9IL10, TLR2, TLR4
6
Immune response Bacterial infections in normal airways
9.8TLR4, TLR2, TLR5, TLR1
79.8IRAK3, TLR1, TLR2, TLR4
89.7IL18, TLR5, TLR2, TLR4
99.6TLR1, TLR10, TLR5, TLR2, TLR4
10
Hide members
9.6TLR4, TLR2, TLR5, TLR10, TLR1
119.6TLR4, TLR2, TLR5, TLR10, TLR1
12
Hide members
9.6TLR4, TLR2, TLR5, TLR10, TLR1
139.6TLR4, TLR2, TLR5, TLR10, TLR1
14
Hide members
9.6TLR4, TLR2, TLR5, TLR10, TLR1
159.6TLR4, TLR2, TLR5, TLR1, IRAK3
169.6IL18, IL10, IL15
17
Hide members
9.5IL18, IL15, TLR2, TLR4
189.5TLR4, TLR2, IL15, IL18
199.5TLR4, TLR2, TLR1, IL10, IL18
20
Hide members
9.5IL18, IL10, TLR5, TLR2, TLR4
21
Hide members
9.5IRAK3, CXCR3, IL15, IL18
22
Hide members
9.4TLR4, TLR2, TLR5, TLR10, TLR1, IRAK3
23
Hide members
9.4TLR4, TLR2, TLR5, TLR10, TLR1, IRAK3
24
Hide members
9.4TLR4, TLR2, TLR5, TLR10, TLR1, IL18
259.3CSF3, IL15, IL10
26
Hide members
9.2TLR4, TLR2, TLR5, TLR1, CXCL9, IL10
279.2TLR4, TLR2, CSF3, IL10, IL18
28
Hide members
9.1IL15, CXCL9, CXCR3, CSF3
29
Hide members
9.1TLR4, TLR2, TLR5, TLR10, TLR1, IL10
30
Hide members
9.1TLR4, TLR2, TLR5, TLR10, TLR1, IRAK3
31
Hide members
9.1TLR4, TLR2, TLR5, TLR10, TLR1, TREM1
32
Hide members
9.0TLR4, CSF3, CXCR3, CXCL9, IL15
33
Hide members
7.6IL18, TLR4, TLR2, TLR5, TLR10, TLR1

Compounds for genes affiliated with Melioidosis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Melioidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.6IL10
2cycloheximide4410.4TLR2, IL18
3pam2csk45910.4TLR1, TLR4, TLR2
4loxoribine44 2811.3TLR4, TLR5, TLR2
5pam3csk45910.3TLR4, TLR2, TLR1
6poly(i:c)5910.3TLR4, TLR2, TLR1
7resiquimod44 5911.3TLR2, TLR1, TLR4
8glucuronoxylomannan4410.2IL10, TLR4, TLR2
9dextran sulfate sodium4410.2IL18, TLR4, MIF
10imiquimod44 28 59 1112.9IL18, IL10, TLR4, TLR2, TLR1
11groalpha449.9CXCR3, IL18, CXCL9, IL10
12creatinine449.9F5, CXCR3, PLAUR, CXCL9
13flagellin44 2810.8IL18, TLR1, TLR2, TLR5, TLR4, CXCR3
14allergens449.8CXCR3, TLR4, IL10, IL18
15tuberculin449.8IL18, IL10, IL15, MIF
16tarc449.8CXCL9, CXCR3, IL18, IL10
17ifn-alpha449.8IL18, CXCR3, TLR4, CXCL9, IL10
18poly(i-c)449.7IL18, IL15, TLR5, TLR2, TLR4
19lipoteichoic acid449.7TLR5, IL18, TLR4, IL10, TLR1, TLR2
20etanercept44 49 1111.7CXCR3, IL15, IL10, IL18
21simvastatin44 49 59 28 11 2414.7IL18, TLR4, IL10, F5, TLR2
22polyinosinic-polycytidylic acid449.7TLR2, IL15, IL10, IL18, TLR4
23dexamethasone44 49 28 1112.6PLAUR, IL15, CXCL9, TLR2, TLR4
24infliximab44 49 1111.6IL18, TLR4, IL15, IL10, CXCR3
25ccl444 2810.6TLR2, CXCR3, CXCL9, IL15
26endotoxin449.6CSF3, CXCR3, F5, IRAK3, PLAUR
27mycophenolate mofetil44 49 1111.6F5, IL10, CSF3, IL18
28ribavirin44 49 1111.6IL18, IL10, CSF3, CXCR3
29anti-fungal449.6IL15, CSF3, TLR2, TLR4
30sb 20358044 5910.6PLAUR, IL18, IL10, MIF, TLR4, TLR2
31peptidoglycan44 2810.5TLR2, TLR5, TLR1, IL15, TLR4, IL10
32superoxide44 2410.5IL15, CSF3, CXCR3
33tgf beta1449.5IL15, TLR4, IL18, IL10, PLAUR
34chloroquine44 2 49 28 1113.4TLR4, IL10, IL18, IL15
35ionomycin449.4CXCL9, IL18, IL15, IL10, TLR2
36rantes449.3CXCR3, IL15, CSF3, TLR4, TLR2, TLR5
37cyclophosphamide44 49 1111.3IL15, F5, CSF3, MIF, CXCL9
38il-12449.3IL10, IL18, IL15
39tacrolimus44 49 1111.2TLR2, IL15, IL10, IL18, TLR4, F5
40il 10449.2CXCL9, IL18, IL15, IL10, CXCR3, TLR2
41histamine44 28 2411.2CXCR3, TLR2, CXCL9, IL15, IL10, IL18
42cyclosporin a44 28 5910.9IL15, CSF3, TLR2, IL10, TLR4, IL18
43thymidine44 249.8PLAUR, CSF3, MIF, CXCR3, IL18, IL10
44alanine448.8PLAUR, TLR4, TLR2, MIF, IL15, IL18
45ccl344 289.8IL10, TLR4, IL18, CXCR3, IL15, CXCL9
46phosphatidylinositol448.7PLAUR, IL15, CXCL9, TLR4, TLR2, TLR5
47retinoic acid44 249.5CSF3, TLR2, MIF, IL18, F5, TLR4
48nitric oxide44 11 2410.5TLR4, CXCR3, TLR2, F5, CXCL9, IL15
49vegf448.0TLR2, PLAUR, IL18, TLR4, IL10, IL15
50tyrosine448.0TLR5, TLR4, CSF3, PLAUR, TLR2, TREM1

GO Terms for genes affiliated with Melioidosis

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Sources:
16Gene Ontology
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Cellular components related to Melioidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.2TLR1, TLR2
2external side of plasma membraneGO:0098979.7TLR4, TLR2, CXCR3, CXCL9
3integral to plasma membraneGO:0058879.1PLAUR, IL15, CXCR3, TLR1, TLR2, TLR4
4extracellular spaceGO:0056158.5IL18, CSF3, F5, MIF, CXCL9, IL15
5extracellular regionGO:0055768.2F5, TREM1, MIF, CXCL9, IL15, IL18
6plasma membraneGO:0058868.2TLR4, TLR2, TLR5, TLR10, TLR1, F5

Biological processes related to Melioidosis according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1cellular response to triacyl bacterial lipopeptideGO:07172710.5TLR2, TLR1
2detection of triacyl bacterial lipopeptideGO:04249510.5TLR2, TLR1
3detection of diacyl bacterial lipopeptideGO:04249610.5TLR1, TLR2
4positive regulation of macrophage cytokine productionGO:06090710.4TLR4, TLR2
5positive regulation of toll-like receptor signaling pathwayGO:03412310.4TLR2, TLR5
6cellular response to lipoteichoic acidGO:07122310.4TLR2, TLR4
7positive regulation of tumor necrosis factor biosynthetic processGO:04253510.4TLR4, TLR2, TLR1
8regulation of cytokine secretionGO:05070710.4TLR1, TLR10, TLR4
9negative regulation of interleukin-17 productionGO:03270010.3TLR2, TLR4
10positive regulation of chemokine productionGO:03272210.3TLR4, TLR2, IL18
11T-helper 1 type immune responseGO:04208810.3IL18, TLR1, TLR4
12positive regulation of NF-kappaB import into nucleusGO:04234610.3IL18, TLR2, TLR4
13type 2 immune responseGO:04209210.3IL18, IL10
14positive regulation of MHC class II biosynthetic processGO:04534810.3IL10, TLR4
15macrophage activationGO:04211610.3TLR1, TLR4
16lipopolysaccharide-mediated signaling pathwayGO:03166310.3TLR4, TLR2, IL18
17positive regulation of tumor necrosis factor productionGO:03276010.3TLR4, TLR2, IL18
18negative regulation of interleukin-12 productionGO:03269510.2IL10, IRAK3, TLR2
19negative regulation of interleukin-6 productionGO:03271510.2IL10, IRAK3, TLR4
20positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.2TLR4, TLR2
21cellular response to mechanical stimulusGO:07126010.2IL18, TLR5, TLR4
22positive regulation of cytokine secretionGO:05071510.2TLR2, MIF, IL10
23negative regulation of tumor necrosis factor productionGO:03272010.2IL10, IRAK3, TLR4
24toll-like receptor signaling pathwayGO:00222410.2TLR10, TLR5, TLR2, TLR4
25positive regulation of interleukin-8 productionGO:03275710.1TLR4, TLR2, TLR5, IL18
26positive regulation of tissue remodelingGO:03410510.1IL15, IL18
27positive regulation of natural killer cell proliferationGO:03281910.1IL15, IL18
28I-kappaB phosphorylationGO:00725210.0TLR4, TLR2
29positive regulation of NF-kappaB transcription factor activityGO:0510929.9IRAK3, TLR2, TLR4
30positive regulation of interleukin-17 productionGO:0327409.8IL15, IL18
31MyD88-dependent toll-like receptor signaling pathwayGO:0027559.8TLR4, TLR2, TLR5, TLR10, TLR1, IRAK3
32cellular response to lipopolysaccharideGO:0712229.8TLR4, CSF3, IL10
33positive regulation of inflammatory responseGO:0507299.8TLR4, TLR2, TLR10, IL15, IL18
34negative regulation of growth of symbiont in hostGO:0441309.7IL10, TLR2
35innate immune responseGO:0450879.5TLR4, TLR2, TLR5, TLR10, TLR1, TREM1
36cell-cell signalingGO:0072679.4CXCL9, IL15, IL10, IL18
37immune responseGO:0069558.8TLR4, TLR2, TLR10, TLR1, CSF3, CXCL9
38inflammatory responseGO:0069548.6IL18, TLR2, TLR5, TLR10, TLR1, MIF

Molecular functions related to Melioidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor bindingGO:0051269.9IL15, MIF
2lipopolysaccharide receptor activityGO:0018759.8TLR2, TLR4
3transmembrane signaling receptor activityGO:0048889.7TLR4, TLR2, TLR10, TLR1
4receptor activityGO:0048729.4TLR4, TLR2, TLR1, TREM1, PLAUR
5cytokine activityGO:0051258.7IL18, IL10, IL15, CXCL9, MIF, CSF3

Products for genes affiliated with Melioidosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Melioidosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet