MCID: MLD001
MIFTS: 73

Melioidosis

Categories: Genetic diseases, Rare diseases, Infectious diseases, Immune diseases

Aliases & Classifications for Melioidosis

MalaCards integrated aliases for Melioidosis:

Name: Melioidosis 53 12 72 49 55 51 3 41 14 69
Melioidosis, Susceptibility to 53 28
Nightcliff Gardener's Disease 12 49
Whitmore's Disease 12 3
Burkholderia Pseudomallei Infection 49
Acute and Fulminating Melioidosis 12
Subacute and Chronic Melioidosis 12
B Pseudomallei Infection 49
Epizootic Lymphangitis 69
Whitmore Disease 49
Pseudoglanders 12

Characteristics:

Orphanet epidemiological data:

55
melioidosis
Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

OMIM 53 615557
Disease Ontology 12 DOID:5052
ICD9CM 34 025
MeSH 41 D008554
Orphanet 55 ORPHA31202
MESH via Orphanet 42 D008554
UMLS via Orphanet 70 C0025229
ICD10 via Orphanet 33 A24.1 A24.2 A24.3 more

Summaries for Melioidosis

NIH Rare Diseases : 49 Melioidosis is an infectious disease caused by the bacteriaBurkholderia pseudomallei that are commonly found in the soil and water. Melioidosis is a rare disease in the United States, but it is common in tropical or subtropical areas of the world, including Southeast Asia, Africa, and Australia. The signs and symptoms of the disease can vary greatly and may mimic those of tuberculosis or common forms of pneumonia. Signs and symptoms may include pain or swelling, fever, abscess, cough, high fever, headache, trouble breathing, and more. Although healthy people can also experience signs and symptoms of the disease, people with certain conditions like diabetes, liver disease, kidney disease, lung disease, thalassemia, cancer, or certain autoimmune diseases are more severely affected. Diagnosis is made by collecting blood, sputum, urine, or pus samples and growing the bacteria. Current treatment is divided into two stages: an intravenous (IV) antibiotic stage and oral antibiotic maintenance stage to prevent recurrence. Last updated: 1/13/2016

MalaCards based summary : Melioidosis, also known as melioidosis, susceptibility to, is related to prostatitis and osteomyelitis, and has symptoms including fever, respiratory distress and chest pain. An important gene associated with Melioidosis is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotypes are Decreased viability in esophageal squamous lineage and hematopoietic system

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection, has material basis in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.

OMIM : 53 Melioidosis is infection caused by the gram-negative, flagellated soil saprophyte Burkholderia pseudomallei, which is endemic in parts of southeast Asia and northern Australia. Sepsis is a common clinical presentation of disease, and lung is the organ most commonly involved. In northern Thailand, where B. pseudomallei is the most common bloodstream isolate, the overall melioidosis mortality rate exceeds 40%, and pneumonia confers more than 2-fold increased risk of death (summary by West et al., 2013). (615557)

CDC : 3 Melioidosis, also called Whitmore's disease, is an infectious disease that can infect humans or animals. The disease is caused by the bacterium Burkholderia pseudomallei.

Wikipedia : 72 Melioidosis is an infectious disease caused by a Gram-negative bacterium, Burkholderia pseudomallei,... more...

Related Diseases for Melioidosis

Diseases related to Melioidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 prostatitis 29.7 IL10 IL6 TNF
2 osteomyelitis 29.7 IFNG IL10 IL6 TNF
3 fasciitis 29.7 IL18 IL6 TNF
4 acute cholangitis 29.5 IL6 TREM1
5 leptospirosis 29.4 IL10 IL6 TLR2 TNF
6 laryngitis 29.4 IL6 TNF
7 penicilliosis 29.4 TLR1 TLR2 TLR4 TNF
8 transverse myelitis 29.3 IL10 IL6 TNF
9 arthritis 29.2 IFNG IL10 IL18 IL6 TNF
10 pulmonary tuberculosis 29.2 IFNG IL10 IL18 TLR2 TNF
11 endocarditis 29.1 IL10 IL6 TLR2 TNF
12 lymphadenitis 29.1 IFNG IL10 IL18 TLR4 TNF
13 bronchiolitis obliterans 29.0 IFNG IL10 IL6 TNF
14 pyelonephritis 29.0 IL10 IL6 TLR4 TNF
15 cutaneous leishmaniasis 29.0 IFNG IL10 TLR2 TLR4 TNF
16 leishmaniasis 29.0 IFNG IL10 TLR2 TLR4 TNF
17 mycobacterium tuberculosis 1 29.0 IFNG IL10 IL18 TLR1 TLR2 TLR4
18 peritonitis 28.9 IFNG IL10 IL6 TLR2 TNF
19 pneumonia 28.7 IL10 IL6 TLR2 TLR4 TLR5 TNF
20 meningitis 28.6 IFNG IL10 IL6 TLR2 TNF
21 brucellosis 28.6 IFNG IL10 IL18 IL6 TLR4 TNF
22 systemic lupus erythematosus 28.1 IFNG IL10 IL18 IL6 TLR4 TLR5
23 q fever 28.0 IFNG IL10 TLR1 TLR10 TLR2 TLR4
24 bronchiolitis 27.5 IFNG IL10 IL6 TLR1 TLR10 TLR4
25 glanders 10.7
26 variola major 10.5 IFNG TLR4
27 hyperlucent lung 10.5 IFNG IL10
28 prosthetic joint infection 10.4 TLR2 TLR4
29 ocular toxoplasmosis 10.4 TLR1 TLR5
30 staphylococcal toxic shock syndrome 10.4 IFNG TNF
31 autoimmune myocarditis 10.4 IFNG TNF
32 pouchitis 10.4 IL10 TLR4
33 sporotrichosis 10.4 IFNG IL10
34 punctate inner choroidopathy 10.4 IL10 TNF
35 penicillin allergy 10.4 IFNG IL18
36 tropical endomyocardial fibrosis 10.4 IL10 TNF
37 spondylarthropathy 10.4 TLR4 TNF
38 systemic onset juvenile idiopathic arthritis 10.4 IL18 TNF
39 baylisascariasis 10.4 IFNG IL10
40 chronic beryllium disease 10.4 IFNG TNF
41 tympanosclerosis 10.4 TLR4 TNF
42 trichosporonosis 10.4 IFNG TNF
43 necrotizing ulcerative gingivitis 10.4 IL10 IL18
44 microscopic polyangiitis 10.4 IL10 TNF
45 multifocal choroiditis 10.4 IL10 TNF
46 tungiasis 10.3 IL10 TNF
47 endomyocardial fibrosis 10.3 IL10 TNF
48 transient hypogammaglobulinemia 10.3 IL10 TNF
49 suppurative otitis media 10.3 TLR2 TLR4 TLR5
50 salmonellosis 10.3 IFNG IL18 TLR4

Graphical network of the top 20 diseases related to Melioidosis:



Diseases related to Melioidosis

Symptoms & Phenotypes for Melioidosis

Clinical features from OMIM:

615557

Symptoms:

12
  • fever
  • respiratory distress
  • chest pain
  • stomach pain

GenomeRNAi Phenotypes related to Melioidosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.23 IL18 IL6 IRAK3 LY96 TLR1 TLR4

MGI Mouse Phenotypes related to Melioidosis:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.23 TLR2 TNF TLR4 TREM1 TLR1 TLR5
2 immune system MP:0005387 10.18 TLR5 TLR2 TNF TLR4 TREM1 LY96
3 cardiovascular system MP:0005385 10.13 TLR5 TLR2 TNF TLR4 IL18 IFNG
4 growth/size/body region MP:0005378 10.13 TLR5 TLR2 TNF TLR4 IL18 IFNG
5 homeostasis/metabolism MP:0005376 10.13 TLR5 TLR2 TNF TLR4 IL18 IFNG
6 digestive/alimentary MP:0005381 10.11 TLR5 TLR2 TNF TLR4 IL18 IFNG
7 endocrine/exocrine gland MP:0005379 10.04 TLR5 TLR2 TNF IRAK3 IFNG IL6
8 adipose tissue MP:0005375 10.01 TLR5 TLR2 TNF TLR4 IL18 IL6
9 integument MP:0010771 9.91 TLR2 TNF TLR4 IL18 IFNG IL6
10 liver/biliary system MP:0005370 9.87 TLR5 TLR2 TNF TLR4 IFNG IL6
11 muscle MP:0005369 9.8 TLR2 TNF TLR4 IL18 IFNG IL6
12 neoplasm MP:0002006 9.7 TLR2 TNF TLR4 IFNG IL6 IL10
13 respiratory system MP:0005388 9.5 TLR5 TLR2 TNF TLR4 IFNG IL6
14 skeleton MP:0005390 9.23 TLR2 TNF TLR4 IFNG IL6 IL10

Drugs & Therapeutics for Melioidosis

Drugs for Melioidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 4 723-46-6 5329
2
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
3 Anti-Bacterial Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Antimalarials Phase 4
6 Antiparasitic Agents Phase 4
7 Antiprotozoal Agents Phase 4
8 Renal Agents Phase 4
9 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
10
Ceftazidime Approved 72558-82-8, 78439-06-2 5481173
11
Meropenem Approved, Investigational 119478-56-7 441130 64778
12 Pharmaceutical Solutions
13 Thienamycins
14 Antibodies
15 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Co-trimoxazole as Maintenance Therapy for Meliodosis Recruiting NCT01420341 Phase 4 Co-trimoxazole 12;Co-trimoxazole 20
2 A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis Unknown status NCT00579956 Meropenem;Ceftazidime
3 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
4 A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand Recruiting NCT02089152
5 Clinical Presentation of Melioidosis in Head and Neck Region Recruiting NCT03048513
6 Study to Obtain Blood and Voided Urine Samples to Improve the Diagnosis of Melioidosis Recruiting NCT02668406

Search NIH Clinical Center for Melioidosis

Cochrane evidence based reviews: melioidosis

Genetic Tests for Melioidosis

Genetic tests related to Melioidosis:

# Genetic test Affiliating Genes
1 Melioidosis, Susceptibility to 28 TLR5

Anatomical Context for Melioidosis

MalaCards organs/tissues related to Melioidosis:

38
Lung, Liver, Bone, Skin, Kidney, Testes, T Cells

Publications for Melioidosis

Articles related to Melioidosis:

(show top 50) (show all 691)
# Title Authors Year
1
Public health response to an imported case of canine melioidosis. ( 29451368 )
2018
2
Virulence of the melioidosis pathogen<i>Burkholderia pseudomallei</i>requires the oxidoreductase membrane protein DsbB. ( 29440370 )
2018
3
Pulmonary Delivery of Ceftazidime for the Treatment of Melioidosis in a Murine Model. ( 29363975 )
2018
4
Pulmonary melioidosis with laryngeal involvement: an unusual site of infection. ( 29374089 )
2018
5
Clinical, Bacteriologic, and Geographic Stratification of Melioidosis Emerges from the Sri Lankan National Surveillance Program. ( 29313474 )
2018
6
Cutaneous melioidosis: two cases of chronic primary forms. ( 29356200 )
2018
7
Melioidosis. ( 29388572 )
2018
8
Retrospective Analysis of Fever and Sepsis Patients from Cambodia Reveals Serological Evidence of Melioidosis. ( 29436341 )
2018
9
Isolated septic arthritis of hip joint: a rare presentation of melioidosis. A case report. ( 29351806 )
2018
10
Melioidosis. ( 29388564 )
2018
11
Imported melioidosis in Japan: a review of cases. ( 29416361 )
2018
12
Melioidosis: the great mimicker presenting as spondylodiscitis. ( 29437812 )
2018
13
Melioidosis, Singapore, 2003-2014. ( 29260679 )
2018
14
Trimethoprim+Sulfamethoxazole Reduces Rates of Melioidosis in High-Risk Hemodialysis Patients. ( 29340327 )
2018
15
Melioidosis: Reinfection going incognito as relapse. ( 29405156 )
2017
16
Molecular detection of leptospirosis and melioidosis co-infection: A case report. ( 28330585 )
2017
17
The epidemiology and clinical features of melioidosis in Far North Queensland: Implications for patient management. ( 28264029 )
2017
18
Comparison of O-polysaccharide and hemolysin co-regulated protein as target antigens for serodiagnosis of melioidosis. ( 28358816 )
2017
19
Anion inhibition profiles of the I^-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei responsible of melioidosis and highly drug resistant to common antibiotics. ( 27914949 )
2017
20
Gastrointestinal manifestations of melioidosis: A single center experience. ( 28353081 )
2017
21
Host gene expression analysis in Sri Lankan melioidosis patients. ( 28628607 )
2017
22
Central nervous system melioidosis in the pediatric age group: review. ( 28451778 )
2017
23
Melioidosis with possible Haemophagocytic lymphohistiocytosis. ( 28571052 )
2017
24
Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis. ( 28939855 )
2017
25
Melioidosis: An Emerging Infection with Fatal Outcomes. ( 28701847 )
2017
26
Emergence of melioidosis in the Indian Ocean region: Two new cases and a literature review. ( 29240770 )
2017
27
A case report of co-infection of Melioidosis and cutaneous Leishmaniasis. ( 28764662 )
2017
28
Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis. ( 28296884 )
2017
29
Pediatric melioidosis in Sarawak, Malaysia: Epidemiological, clinical and microbiological characteristics. ( 28599008 )
2017
30
Type III Secretion in the Melioidosis Pathogen Burkholderia pseudomallei. ( 28664152 )
2017
31
DNA vaccination resurfaces in the struggle against melioidosis. ( 28481716 )
2017
32
Septicemic Melioidosis with Ruptured Splenic Abscess in a Patient with Thalassemia Intermedia. ( 28250624 )
2017
33
Vaccines for the Prevention of Melioidosis and Glanders. ( 29242769 )
2017
34
Sulfonamide inhibition profile of the I^-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis. ( 28025002 )
2017
35
Imported Case of Melioidosis in Oman: Case Report. ( 28042405 )
2017
36
A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-I+ levels in human melioidosis. ( 28475641 )
2017
37
Melioidosis with Portal Vein Thrombosis. ( 28473933 )
2017
38
The gut microbiota as a modulator of innate immunity during melioidosis. ( 28422970 )
2017
39
A case-control study of community-acquired Acinetobacter baumannii pneumonia and melioidosis pneumonia in northeast Thailand: an emerging fatal disease with unique clinical features. ( 27789057 )
2017
40
Acute bacteremic pneumonia due to melioidosis developing in the intensive care setting. ( 28417070 )
2017
41
Notes from the Field: Travel-Associated Melioidosis and Resulting Laboratory Exposures - United States, 2016. ( 28934180 )
2017
42
Splenic Infarction and Rupture Due to Melioidosis. ( 29208262 )
2017
43
Accidental Occupational Exposure to Burkholderia pseudomallei in South Korea Did Not Result in Melioidosis. ( 28414016 )
2017
44
Functional characterisation of Burkholderia pseudomallei biotin protein ligase: A toolkit for anti-melioidosis drug development. ( 28454708 )
2017
45
Melioidosis in lower provincial Cambodia: A case series from a prospective study of sepsis in Takeo Province. ( 28902844 )
2017
46
Non-healing chest wall ulcer caused by cutaneous melioidosis. ( 28232013 )
2017
47
An avirulent Burkholderia pseudomallei a88purM strain with atypical type B LPS: expansion of the toolkit for biosafe studies of melioidosis. ( 28592242 )
2017
48
Are brucellosis, Q fever and melioidosis potential causes of febrile illness in Madagascar? ( 28502643 )
2017
49
A simple laboratory algorithm for diagnosis of melioidosis in resource-constrained areas: a study from north-central Vietnam. ( 28780059 )
2017
50
Glanders And Melioidosis ( 28846298 )
2017

Variations for Melioidosis

Expression for Melioidosis

LifeMap Discovery
Genes differentially expressed in tissues of Melioidosis patients vs. healthy controls: 35 (show top 50) (show all 181)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CD177 CD177 molecule Blood + 8.41 0.000
2 ZDHHC19 zinc finger, DHHC-type containing 19 Blood + 6.91 0.000
3 MMP8 matrix metallopeptidase 8 Blood + 6.49 0.000
4 SLC51A solute carrier family 51, alpha subunit Blood + 6.46 0.000
5 HP haptoglobin Blood + 6.23 0.000
6 FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide Blood - 6.00 0.000
7 GPR84 G protein-coupled receptor 84 Blood + 5.86 0.000
8 ANKRD22 ankyrin repeat domain 22 Blood + 5.72 0.000
9 OLAH oleoyl-ACP hydrolase Blood + 5.54 0.000
10 LRRN3 leucine rich repeat neuronal 3 Blood - 5.51 0.000
11 PCOLCE2 procollagen C-endopeptidase enhancer 2 Blood + 5.47 0.000
12 C1QC complement component 1, q subcomponent, C chain Blood + 5.42 0.000
13 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Blood + 5.39 0.000
14 CCNA1 cyclin A1 Blood + 5.14 0.000
15 C1QB complement component 1, q subcomponent, B chain Blood + 5.09 0.000
16 LINC00668 long intergenic non-protein coding RNA 668 Blood + 4.99 0.000
17 CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Blood + 4.98 0.000
18 FGF13 fibroblast growth factor 13 Blood + 4.96 0.000
19 NOV nephroblastoma overexpressed Blood - 4.84 0.000
20 PLVAP plasmalemma vesicle associated protein Blood - 4.76 0.000
21 KL klotho Blood + 4.74 0.000
22 SLCO4A1 solute carrier organic anion transporter family, member 4A1 Blood + 4.73 0.000
23 MYO10 myosin X Blood + 4.68 0.000
24 SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 Blood + 4.68 0.000
25 RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 Blood - 4.67 0.000
26 RETN resistin Blood + 4.65 0.000
27 CD274 CD274 molecule Blood + 4.44 0.000
28 MCEMP1 mast cell-expressed membrane protein 1 Blood + 4.44 0.000
29 BMX BMX non-receptor tyrosine kinase Blood + 4.41 0.000
30 SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 Blood + 4.38 0.000
31 CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) Blood + 4.38 0.000
32 GRB10 growth factor receptor-bound protein 10 Blood + 4.37 0.000
33 CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 Blood - 4.25 0.000
34 LINC01220 long intergenic non-protein coding RNA 1220 Blood + 4.20 0.000
35 LTF lactotransferrin Blood + 4.19 0.000
36 SLC26A8 solute carrier family 26 (anion exchanger), member 8 Blood + 4.18 0.000
37 ARG1 arginase 1 Blood + 4.17 0.000
38 IL18R1 interleukin 18 receptor 1 Blood + 4.17 0.000
39 IL1R2 interleukin 1 receptor, type II Blood + 4.08 0.000
40 SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 Blood + 4.06 0.000
41 CFH complement factor H Blood + 4.03 0.000
42 G0S2 G0/G1 switch 2 Blood + 4.02 0.000
43 MMP9 matrix metallopeptidase 9 Blood + 3.97 0.000
44 FCAR Fc fragment of IgA receptor Blood + 3.94 0.000
45 SCN9A sodium channel, voltage gated, type IX alpha subunit Blood + 3.94 0.000
46 FAM20A family with sequence similarity 20, member A Blood + 3.94 0.000
47 KRTAP19-6 keratin associated protein 19-6 Blood + 3.93 0.000
48 TDRD9 tudor domain containing 9 Blood + 3.92 0.000
49 KREMEN1 kringle containing transmembrane protein 1 Blood + 3.86 0.000
50 HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Blood + 3.84 0.000
Search GEO for disease gene expression data for Melioidosis.

Pathways for Melioidosis

Pathways related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 IFNG IL10 IL18 IL6 IRAK3 LY96
2
Show member pathways
13.61 IFNG IL10 IL18 IL6 LY96 TLR4
3
Show member pathways
13.55 IRAK3 LY96 TLR1 TLR10 TLR2 TLR4
4
Show member pathways
13.44 IL10 IL18 IL6 IRAK3 TLR1 TLR10
5
Show member pathways
13.31 IFNG IL10 IL18 IL6 IRAK3 TNF
6
Show member pathways
13.26 IFNG IRAK3 TLR1 TLR10 TLR2 TLR4
7
Show member pathways
13 IL18 IL6 LY96 TLR1 TLR10 TLR2
8
Show member pathways
12.85 IFNG IL18 IL6 TLR2 TLR4 TNF
9
Show member pathways
12.78 IL6 IRAK3 TLR1 TLR10 TLR2 TLR4
10
Show member pathways
12.7 IRAK3 LY96 TLR1 TLR10 TLR2 TLR4
11
Show member pathways
12.68 IFNG IL18 IL6 TNF
12 12.65 IFNG IL10 IRAK3 TLR1 TLR2 TNF
13
Show member pathways
12.63 IFNG IL10 IL18 IL6 TLR2 TLR4
14
Show member pathways
12.62 IFNG IL10 IL18 IL6 TNF
15
Show member pathways
12.59 IFNG IL10 IL18 TNF
16
Show member pathways
12.54 IL6 TLR2 TLR4 TNF
17
Show member pathways
12.51 IFNG IL10 IL6 LY96 TLR1 TLR2
18
Show member pathways
12.46 LY96 TLR1 TLR2 TLR4
19
Show member pathways
12.42 IFNG IL10 IL6 TNF
20
Show member pathways
12.41 IFNG IL6 TLR2 TLR5 TNF
21
Show member pathways
12.37 IFNG IL6 IRAK3 LY96 TLR4 TNF
22
Show member pathways
12.35 IFNG IL10 LY96 TLR2 TLR4 TNF
23
Show member pathways
12.26 IFNG IL10 IL18 IL6 TNF
24 12.26 IFNG IL10 IL18 IL6 TLR1 TLR2
25 12.18 TLR1 TLR10 TLR2 TLR4 TLR5
26
Show member pathways
12.14 TLR1 TLR10 TLR2 TLR4 TLR5
27 12.14 IFNG IL6 TLR1 TLR10 TLR2 TLR4
28
Show member pathways
12.09 IL6 IRAK3 LY96 TLR1 TLR10 TLR2
29 12.07 IFNG IL6 TLR4 TNF
30 12.05 IFNG IL10 IL6 TNF
31 12.04 IL10 IL18 IL6 TNF
32 12 IFNG IL10 IL6 TLR2 TLR4 TNF
33 11.96 IFNG IL18 IL6 TLR4 TLR5
34 11.95 TLR1 TLR10 TLR2 TLR4 TLR5
35 11.94 IFNG IL18 IL6 TLR2 TLR4 TNF
36
Show member pathways
11.94 IFNG IL6 TLR1 TLR10 TLR2 TLR4
37 11.9 IFNG IL6 TLR4
38 11.89 IL10 IL6 LY96 TLR4 TNF
39 11.88 IFNG IL10 IL18 TNF
40 11.87 LY96 TLR4 TNF
41
Show member pathways
11.86 IL6 LY96 TLR4
42 11.84 IFNG IL10 IL6 TNF
43 11.82 IFNG IL10 IL6
44 11.77 IL10 IL6 TLR2 TLR4 TLR5 TNF
45 11.73 LY96 TLR4 TNF
46 11.7 IRAK3 LY96 TLR4 TNF
47
Show member pathways
11.68 IFNG IL6 TNF
48 11.67 IL18 IL6 TLR2 TLR4 TLR5 TNF
49
Show member pathways
11.67 IFNG IL10 IL18 IL6 TLR1 TLR10
50 11.66 IL10 IL18 IL6 TNF

GO Terms for Melioidosis

Cellular components related to Melioidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor complex GO:0046696 9.16 LY96 TLR4
2 intrinsic component of plasma membrane GO:0031226 9.13 LY96 TLR2 TLR4
3 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.99 IL10 TLR1 TLR4 TLR5 TNF
2 response to lipopolysaccharide GO:0032496 9.97 IL10 IRAK3 LY96 TLR2 TLR4
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL6 IRAK3 TLR2 TLR4 TNF
4 response to virus GO:0009615 9.91 IFNG IRAK3 TNF
5 immune response GO:0006955 9.91 IFNG IL10 IL18 IL6 TLR1 TLR10
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.9 IL10 IL6 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.9 IL6 TLR2 TNF
8 positive regulation of inflammatory response GO:0050729 9.88 IL18 TLR10 TLR2 TLR4
9 cellular response to lipopolysaccharide GO:0071222 9.88 IL10 IL6 LY96 TLR4 TLR5 TNF
10 apoptotic signaling pathway GO:0097190 9.87 LY96 TLR4 TNF
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.86 IFNG IL18 IL6
12 response to glucocorticoid GO:0051384 9.86 IL10 IL6 TNF
13 humoral immune response GO:0006959 9.86 IFNG IL6 TNF TREM1
14 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.85 LY96 TLR4 TNF
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 IL18 IL6 TNF
16 positive regulation of interleukin-6 production GO:0032755 9.85 IL6 TLR2 TLR4 TNF
17 positive regulation of tumor necrosis factor production GO:0032760 9.84 LY96 TLR2 TLR4
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IFNG TLR4 TLR5 TNF
19 positive regulation of interferon-gamma production GO:0032729 9.82 IL18 TLR4 TNF
20 negative regulation of tumor necrosis factor production GO:0032720 9.82 IL10 IRAK3 TLR4
21 positive regulation of interleukin-8 production GO:0032757 9.8 TLR2 TLR4 TLR5 TNF
22 positive regulation of interleukin-12 production GO:0032735 9.78 IFNG TLR2 TLR4
23 negative regulation of interleukin-6 production GO:0032715 9.78 IL10 IRAK3 TLR4 TNF
24 toll-like receptor signaling pathway GO:0002224 9.77 LY96 TLR1 TLR10 TLR2 TLR4
25 positive regulation of NF-kappaB import into nucleus GO:0042346 9.76 IL18 TLR2 TLR4 TNF
26 positive regulation of osteoclast differentiation GO:0045672 9.74 IFNG TNF
27 necroptotic process GO:0070266 9.74 LY96 TLR4
28 toll-like receptor 4 signaling pathway GO:0034142 9.74 LY96 TLR4
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.74 IFNG TNF
30 positive regulation of macrophage activation GO:0043032 9.74 IL10 TLR4
31 cell activation GO:0001775 9.74 TLR1 TLR2
32 negative regulation of growth of symbiont in host GO:0044130 9.74 IL10 TNF
33 positive regulation of interleukin-8 secretion GO:2000484 9.73 TLR1 TLR2
34 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.73 TLR2 TLR4
35 response to molecule of bacterial origin GO:0002237 9.73 IL10 TLR2
36 negative regulation of interleukin-12 production GO:0032695 9.73 IL10 IRAK3
37 positive regulation of chemokine production GO:0032722 9.73 IL6 TLR2 TLR4 TNF
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 TNF
39 I-kappaB phosphorylation GO:0007252 9.72 TLR2 TLR4
40 T-helper 1 type immune response GO:0042088 9.72 IL18 TLR4
41 interferon-gamma production GO:0032609 9.72 IL18 TLR4
42 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 IL18 LY96 TLR2 TLR4 TNF
43 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.71 TLR1 TLR4
44 negative regulation of interleukin-17 production GO:0032700 9.71 IFNG TLR4
45 cellular response to lipoteichoic acid GO:0071223 9.71 TLR2 TLR4
46 macrophage activation GO:0042116 9.71 TLR1 TLR4
47 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF
48 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.7 TLR4 TNF
49 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
50 response to peptidoglycan GO:0032494 9.69 IL6 IRAK3

Molecular functions related to Melioidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.56 TLR1 TLR10 TLR4 TLR5
2 receptor activity GO:0004872 9.46 TLR1 TLR2 TLR4 TREM1
3 cytokine activity GO:0005125 9.35 IFNG IL10 IL18 IL6 TNF
4 lipopeptide binding GO:0071723 9.32 TLR1 TLR2
5 lipopolysaccharide receptor activity GO:0001875 8.8 LY96 TLR2 TLR4

Sources for Melioidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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