MCID: MLD001
MIFTS: 65

Melioidosis malady

Infectious diseases, Immune diseases categories

Summaries for Melioidosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection, has material basis in burkholderia pseudomallei, which is transmitted by contact with the contaminated water or soil. the infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.

MalaCards: Melioidosis, also known as acute and fulminating melioidosis, is related to pneumonia and tuberculosis, and has symptoms including stomach pain, respiratory distress and chest pain. An important gene associated with Melioidosis is TLR4 (toll-like receptor 4), and among its related pathways are MIF Action Through Endocytic Pathway and MSP-RON Signaling. The compounds gm-csf and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and skin, and related mouse phenotypes are tumorigenesis and liver/biliary system.

CDC:3 Melioidosis, also called Whitmore's disease, is an infectious disease that can infect humans or animals. The disease is caused by the bacterium Burkholderia pseudomallei.

Wikipedia:63 Melioidosis is an infectious disease caused by a Gram-negative bacterium, Burkholderia pseudomallei,... more...

Aliases & Classifications for Melioidosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Immune diseases


Aliases & Descriptions:

melioidosis 8 10 44 60
acute and fulminating melioidosis 8
subacute and chronic melioidosis 8
nightcliff gardener's disease 8
melioidosis, unspecified 8
epizootic lymphangitis 60
whitmore's disease 8
pseudoglanders 8


External Ids:

Disease Ontology8 DOID:5052
ICD9CM27 025
MeSH34 D008554

Related Diseases for Melioidosis

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17GeneCards, 18GeneDecks
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Diseases related to Melioidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.5TLR4, TLR2, TLR5, CSF3, IL10, TREM1
2tuberculosis30.4IL18, IL10, CXCL9, CXCR3, MIF, TREM1
3arthritis30.3IL18, IL10, CXCL9, CXCR3, MIF, TLR2
4cystic fibrosis30.0TLR4
5hepatitis30.0TLR2, IL18
6pulmonary tuberculosis30.0TLR2, IL18, IL10
7bronchiolitis29.8TLR4
8meningitis29.8TLR2
9bronchiolitis obliterans29.8CXCR3
10neutropenia29.8CSF3
11pancreatitis29.8IL10
12peritonitis29.8TLR2, IL15
13lupus erythematosus29.8F5, IL18
14leukemia29.7TLR2, TLR4, CXCR3, IL15, PLAUR, CSF3
15systemic lupus erythematosus29.7TLR2, TLR4, TLR5, IL18, CXCR3, IL10
16lymphangitis10.8
17histoplasmosis10.6
18glanders10.5
19melioidosis, susceptibilty to10.4
20splenic abscess10.3
21osteomyelitis10.2
22leptospirosis10.2
23septic arthritis10.2
24prostatitis10.2
25cellulitis10.1
26cerebritis10.1
27necrotizing fasciitis10.1
28fasciitis10.1
29orbital cellulitis10.0
30aortic aneurysm10.0
31mediastinitis10.0
32pericardial effusion10.0
33pericarditis10.0
34leprosy10.0TLR2
35measles10.0TLR2
36otitis media10.0TLR2
37herpes simplex10.0TLR2
38viral hepatitis10.0TLR2
39acute myocardial infarction10.0MIF
40pulmonary fibrosis10.0CXCR3
41skin disease10.0CXCL9
42visceral leishmaniasis10.0FAM120B
43aspergillosis10.0TLR4, TLR2
44graves' disease10.0CXCR3
45encephalitis10.0TLR2, CXCL9
46multiple myeloma10.0CSF3
47adenocarcinoma10.0PLAUR
48infertility10.0MIF
49filariasis10.0TLR2, TLR4
50celiac disease10.0IL15

Graphical network of the top 20 diseases related to Melioidosis:



Diseases related to melioidosis

Clinical Features for Melioidosis

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8Disease Ontology
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Symptoms:

8
  • stomach pain
  • respiratory distress
  • chest pain
  • fever

Drugs & Therapeutics for Melioidosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Melioidosis

Drug clinical trials:

Search ClinicalTrials for Melioidosis

Search NIH Clinical Center for Melioidosis

Search CenterWatch for Melioidosis

Genetic Tests for Melioidosis

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Anatomical Context for Melioidosis

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32MalaCards
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MalaCards organs/tissues related to Melioidosis:

32
Bone, Lung, Skin, Testes, Liver, T cells, Prostate, Whole blood, Breast, Monocytes, Endothelial, Myeloid, Spleen, Kidney, Brain, Spinal cord

Animal Models for Melioidosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Melioidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.4TREM1, MIF, CXCR3, IL10
2MP:00053709.2TLR2, TLR5, F5, IL10, PLAUR, TLR4
3MP:00053858.4TLR4, TLR2, TLR5, F5, CXCR3, IL15
4MP:00053848.1TLR4, TLR2, TLR5, TREM1, MIF, CXCR3
5MP:00053768.0TLR4, TLR2, TLR5, F5, TREM1, MIF
6MP:00053977.7TLR4, TLR2, TLR5, CSF3, IRAK3, TREM1
7MP:00053877.1PLAUR, TLR4, TLR2, TLR5, TLR1, CSF3

Publications for Melioidosis

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50PubMed
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Articles related to Melioidosis:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Induction of mouse melioidosis with meningitis by CD11b+ phagocytic cells harboring intracellular B. pseudomallei as a Trojan horse. (23951382)
2013
2
In situ hybridization to detect and identify Burkholderia pseudomallei in human melioidosis. (24186135)
2013
3
Protection against experimental melioidosis following immunization with live Burkholderia thailandensis expressing a manno-heptose capsule. (23677322)
2013
4
Guillain Barre syndrome as a manifestation of neurological melioidosis. (24339608)
2013
5
Sinonasal melioidosis in a returned traveller presenting with nasal cellulitis and sinusitis. (23936707)
2013
6
BLF1, the first Burkholderia pseudomallei toxin, connects inhibition of host protein synthesis with melioidosis. (22817745)
2012
7
Evolution of Burkholderia pseudomallei in recurrent melioidosis. (22615773)
2012
8
Clinical features and epidemiology of melioidosis pneumonia: results from a 21-year study and review of the literature. (22057702)
2012
9
Towards a rapid molecular diagnostic for melioidosis: Comparison of DNA extraction methods from clinical specimens. (22108495)
2012
10
Molecular investigations of a locally acquired case of melioidosis in Southern AZ, USA. (22028940)
2011
11
VIth World Melioidosis Congress report: celebrating a century of research. (21449838)
2011
12
Typhoon-related leptospirosis and melioidosis, Taiwan, 2009. (21762606)
2011
13
Imported melioidosis in Danish travellers: a diagnostic challenge. (20297927)
2010
14
Melioidosis and pulmonary tuberculosis co-infection in a diabetic. (20582178)
2010
15
Spectrum of melioidosis in the suburbs of Mangalore, S West Coast of India. (20578496)
2010
16
Melioidosis in an urban-dwelling Taiwanese man with splenic abscesses. (20709809)
2010
17
Melioidosis risk in a tropical industrial environment. (19141844)
2009
18
Prostatic abscess due to Burkholderia pseudomallei: 81 cases from a 19-year prospective melioidosis study. (19524969)
2009
19
Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis). (19114913)
2009
20
Recurrent cutaneous melioidosis treated with surgery and antibiotics. (18838323)
2009
21
Non-septicemic melioidosis presenting as cardiac tamponade. (18784243)
2008
22
Melioidosis. (19051712)
2008
23
Inhalation of Burkholderia thailandensis results in lethal necrotizing pneumonia in mice: a surrogate model for pneumonic melioidosis. (19121672)
2008
24
Misdiagnosing melioidosis. (17479916)
2007
25
Melioidosis: a review of orthopedic manifestations, clinical features, diagnosis and management. (17932451)
2007
26
Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis. (17517877)
2007
27
Prevalence of melioidosis in the Er-Ren River Basin, Taiwan: implications for transmission. (17596372)
2007
28
Multiple visceral abscess in a case of melioidosis. (16505577)
2006
29
Cutaneous melioidosis. (17062053)
2006
30
Melioidosis in children from Kuala Lumpur, Malaysia. (16925959)
2006
31
Multilocus sequence typing of historical Burkholderia pseudomallei isolates collected in Southeast Asia from 1964 to 1967 provides insight into the epidemiology of melioidosis. (16891516)
2006
32
Antibodies from patients with melioidosis recognize Burkholderia mallei but not Burkholderia thailandensis antigens in the indirect hemagglutination assay. (16145163)
2005
33
Changing epidemiology of melioidosis? A case of acute pulmonary melioidosis with fatal outcome imported from Brazil. (16181507)
2005
34
Cerebral melioidosis. (15727617)
2005
35
The role and significance of sputum cultures in the diagnosis of melioidosis. (16222004)
2005
36
Role and significance of quantitative urine cultures in diagnosis of melioidosis. (15872255)
2005
37
Melioidosis in Mauritius. (15705340)
2005
38
Adaptive immunity in melioidosis: a possible role for T cells in determining outcome of infection with Burkholderia pseudomallei. (15380526)
2004
39
Septicaemic melioidosis in a tertiary care hospital in south India. (14575177)
2003
40
Ethical problems of evaluating a new treatment for melioidosis. (14644975)
2003
41
A case of nonfatal cutaneous melioidosis. (14604083)
2003
42
Recombinant truncated flagellin of Burkholderia pseudomallei as a molecular probe for diagnosis of melioidosis. (12738642)
2003
43
Melioidosis. (11964912)
2002
44
Burkholderia pseudomallei infection, or melioidosis, and nephrotic syndrome. (11773478)
2002
45
Melioidosis splenic abscess--an unusual presentation as osteomyelitis of rib. (11242625)
2001
46
Fatal human melioidosis acquired in a subtropical Australian city. (11693877)
2001
47
Retrospective study on the diagnostic value of IgG ELISA, dot immunoassay and indirect hemagglutination in septicemic melioidosis. (11699719)
2001
48
Melioidosis and Pandora's box in the Lao People's Democratic Republic. (11181133)
2001
49
Mycotic arch aneurysm and aortoesophageal fistula in a patient with melioidosis. (11308198)
2001
50
Melioidosis research in China. (11080506)
2000

Genetic Variations for Melioidosis

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Expression for genes affiliated with Melioidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Melioidosis

Search GEO for disease gene expression data for Melioidosis.

Pathways for genes affiliated with Melioidosis

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology, 53Reactome, 52R&D Systems, 59Tocris Bioscience, 55SinoBiological, 37NCBI BioSystems Database
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Pathways related to Melioidosis according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1MIF, TLR4
29.9IL18, TLR2, TLR4
39.9TLR4, TLR5, IL18
4
Hide members
9.9TLR4, IRAK3, MIF
59.9IL10, TLR2, TLR4
6
Immune response Bacterial infections in normal airways
9.8TLR4, TLR2, TLR5, TLR1
79.8IRAK3, TLR1, TLR2, TLR4
89.7IL18, TLR5, TLR2, TLR4
99.6TLR1, TLR10, TLR5, TLR2, TLR4
10
Hide members
9.6TLR4, TLR2, TLR5, TLR10, TLR1
119.6TLR4, TLR2, TLR5, TLR10, TLR1
12
Hide members
9.6TLR4, TLR2, TLR5, TLR10, TLR1
139.6TLR4, TLR2, TLR5, TLR10, TLR1
14
Hide members
9.6TLR4, TLR2, TLR5, TLR10, TLR1
159.6TLR4, TLR2, TLR5, TLR1, IRAK3
169.6IL18, IL10, IL15
17
Hide members
9.5IL18, IL15, TLR2, TLR4
189.5TLR4, TLR2, IL15, IL18
199.5TLR4, TLR2, TLR1, IL10, IL18
20
Hide members
9.5IL18, IL10, TLR5, TLR2, TLR4
21
Hide members
9.5IRAK3, CXCR3, IL15, IL18
22
Hide members
9.4TLR4, TLR2, TLR5, TLR10, TLR1, IRAK3
23
Hide members
9.4TLR4, TLR2, TLR5, TLR10, TLR1, IRAK3
24
Hide members
9.4TLR4, TLR2, TLR5, TLR10, TLR1, IL18
259.3CSF3, IL15, IL10
26
Hide members
9.2TLR4, TLR2, TLR5, TLR1, CXCL9, IL10
279.2TLR4, TLR2, CSF3, IL10, IL18
28
Hide members
9.1IL15, CXCL9, CXCR3, CSF3
29
Hide members
9.1TLR4, TLR2, TLR5, TLR10, TLR1, IL10
30
Hide members
9.1TLR4, TLR2, TLR5, TLR10, TLR1, IRAK3
31
Hide members
9.1TLR4, TLR2, TLR5, TLR10, TLR1, TREM1
32
Hide members
9.0TLR4, CSF3, CXCR3, CXCL9, IL15
33
Hide members
7.6IL18, TLR4, TLR2, TLR5, TLR10, TLR1

Compounds for genes affiliated with Melioidosis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Melioidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.6IL10
2cycloheximide4410.4IL18, TLR2
3pam2csk45910.4TLR4, TLR2, TLR1
4pam3csk45910.4TLR4, TLR2, TLR1
5poly(i:c)5910.3TLR4, TLR1, TLR2
6loxoribine44 2811.3TLR5, TLR2, TLR4
7resiquimod44 5911.3TLR4, TLR2, TLR1
8glucuronoxylomannan4410.2IL10, TLR2, TLR4
9dextran sulfate sodium4410.2TLR4, MIF, IL18
10imiquimod44 28 59 1112.9TLR4, TLR2, TLR1, IL10, IL18
11groalpha449.9CXCR3, CXCL9, IL10, IL18
12creatinine449.9F5, CXCR3, CXCL9, PLAUR
13flagellin44 2810.8TLR4, TLR2, TLR5, TLR1, CXCR3, IL18
14allergens449.8TLR4, CXCR3, IL10, IL18
15tuberculin449.8IL18, IL10, IL15, MIF
16tarc449.8CXCR3, CXCL9, IL10, IL18
17ifn-alpha449.8TLR4, CXCR3, CXCL9, IL10, IL18
18poly(i-c)449.7TLR4, TLR2, TLR5, IL15, IL18
19lipoteichoic acid449.7TLR4, TLR2, TLR5, TLR1, IL10, IL18
20etanercept44 49 1111.7IL18, IL10, IL15, CXCR3
21simvastatin44 49 59 28 11 2414.7TLR4, TLR2, F5, IL10, IL18
22polyinosinic-polycytidylic acid449.7TLR4, TLR2, IL15, IL10, IL18
23dexamethasone44 49 28 1112.6TLR4, TLR2, CXCL9, IL15, PLAUR
24infliximab44 49 1111.6TLR4, CXCR3, IL15, IL10, IL18
25ccl444 2810.6TLR2, CXCR3, CXCL9, IL15
26endotoxin449.6PLAUR, CSF3, IRAK3, F5, CXCR3
27mycophenolate mofetil44 49 1111.6IL18, IL10, F5, CSF3
28ribavirin44 49 1111.6CSF3, CXCR3, IL10, IL18
29anti-fungal449.6IL15, CSF3, TLR2, TLR4
30sb 20358044 5910.6PLAUR, IL18, IL10, MIF, TLR2, TLR4
31peptidoglycan44 2810.5TLR4, TLR2, TLR5, TLR1, IL15, IL10
32superoxide44 2410.5CSF3, CXCR3, IL15
33tgf beta1449.5TLR4, IL15, IL10, IL18, PLAUR
34chloroquine44 2 49 28 1113.4IL18, IL10, IL15, TLR4
35ionomycin449.4IL18, IL10, IL15, CXCL9, TLR2
36rantes449.3TLR4, TLR2, TLR5, CSF3, CXCR3, IL15
37cyclophosphamide44 49 1111.3CSF3, F5, MIF, CXCL9, IL15
38il-12449.3IL18, IL10, IL15
39tacrolimus44 49 1111.2TLR4, TLR2, F5, CXCR3, IL15, IL10
40il 10449.2TLR4, TLR2, CXCR3, CXCL9, IL15, IL10
41histamine44 28 2411.2TLR4, TLR2, CXCR3, CXCL9, IL15, IL10
42cyclosporin a44 28 5910.9IL18, IL10, IL15, CSF3, TLR2, TLR4
43thymidine44 249.8CSF3, MIF, CXCR3, IL15, IL10, IL18
44alanine448.8TLR2, F5, MIF, IL15, IL18, PLAUR
45ccl344 289.8TLR4, TLR2, CSF3, CXCR3, CXCL9, IL15
46phosphatidylinositol448.7TLR4, TLR2, TLR5, CXCR3, CXCL9, IL15
47retinoic acid44 249.5TLR4, TLR2, CSF3, F5, MIF, IL15
48nitric oxide44 11 2410.5TLR4, TLR2, F5, MIF, CXCR3, CXCL9
49vegf448.0TLR4, TLR2, CSF3, F5, MIF, CXCR3
50tyrosine448.0TLR4, TLR2, TLR5, CSF3, TREM1, MIF

GO Terms for genes affiliated with Melioidosis

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Sources:
16Gene Ontology
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Cellular components related to Melioidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.2TLR1, TLR2
2external side of plasma membraneGO:0098979.7TLR4, TLR2, CXCR3, CXCL9
3integral to plasma membraneGO:0058879.1PLAUR, IL15, CXCR3, TLR1, TLR2, TLR4
4extracellular spaceGO:0056158.5IL18, CSF3, F5, MIF, CXCL9, IL15
5extracellular regionGO:0055768.2F5, TREM1, MIF, CXCL9, IL15, IL18
6plasma membraneGO:0058868.2TLR4, TLR2, TLR5, TLR10, TLR1, F5

Biological processes related to Melioidosis according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1cellular response to triacyl bacterial lipopeptideGO:07172710.5TLR2, TLR1
2detection of triacyl bacterial lipopeptideGO:04249510.5TLR2, TLR1
3detection of diacyl bacterial lipopeptideGO:04249610.5TLR1, TLR2
4positive regulation of macrophage cytokine productionGO:06090710.4TLR4, TLR2
5positive regulation of toll-like receptor signaling pathwayGO:03412310.4TLR2, TLR5
6cellular response to lipoteichoic acidGO:07122310.4TLR2, TLR4
7positive regulation of tumor necrosis factor biosynthetic processGO:04253510.4TLR4, TLR2, TLR1
8regulation of cytokine secretionGO:05070710.4TLR1, TLR10, TLR4
9negative regulation of interleukin-17 productionGO:03270010.3TLR2, TLR4
10positive regulation of chemokine productionGO:03272210.3TLR4, TLR2, IL18
11T-helper 1 type immune responseGO:04208810.3IL18, TLR1, TLR4
12positive regulation of NF-kappaB import into nucleusGO:04234610.3IL18, TLR2, TLR4
13type 2 immune responseGO:04209210.3IL18, IL10
14positive regulation of MHC class II biosynthetic processGO:04534810.3IL10, TLR4
15macrophage activationGO:04211610.3TLR1, TLR4
16lipopolysaccharide-mediated signaling pathwayGO:03166310.3TLR4, TLR2, IL18
17positive regulation of tumor necrosis factor productionGO:03276010.3TLR4, TLR2, IL18
18negative regulation of interleukin-12 productionGO:03269510.2IL10, IRAK3, TLR2
19negative regulation of interleukin-6 productionGO:03271510.2IL10, IRAK3, TLR4
20positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.2TLR4, TLR2
21cellular response to mechanical stimulusGO:07126010.2IL18, TLR5, TLR4
22positive regulation of cytokine secretionGO:05071510.2TLR2, MIF, IL10
23negative regulation of tumor necrosis factor productionGO:03272010.2IL10, IRAK3, TLR4
24toll-like receptor signaling pathwayGO:00222410.2TLR10, TLR5, TLR2, TLR4
25positive regulation of interleukin-8 productionGO:03275710.1TLR4, TLR2, TLR5, IL18
26positive regulation of tissue remodelingGO:03410510.1IL15, IL18
27positive regulation of natural killer cell proliferationGO:03281910.1IL15, IL18
28I-kappaB phosphorylationGO:00725210.0TLR4, TLR2
29positive regulation of NF-kappaB transcription factor activityGO:0510929.9IRAK3, TLR2, TLR4
30positive regulation of interleukin-17 productionGO:0327409.8IL15, IL18
31MyD88-dependent toll-like receptor signaling pathwayGO:0027559.8TLR4, TLR2, TLR5, TLR10, TLR1, IRAK3
32cellular response to lipopolysaccharideGO:0712229.8TLR4, CSF3, IL10
33positive regulation of inflammatory responseGO:0507299.8TLR4, TLR2, TLR10, IL15, IL18
34negative regulation of growth of symbiont in hostGO:0441309.7IL10, TLR2
35innate immune responseGO:0450879.5TLR4, TLR2, TLR5, TLR10, TLR1, TREM1
36cell-cell signalingGO:0072679.4CXCL9, IL15, IL10, IL18
37immune responseGO:0069558.8TLR4, TLR2, TLR10, TLR1, CSF3, CXCL9
38inflammatory responseGO:0069548.6IL18, TLR2, TLR5, TLR10, TLR1, MIF

Molecular functions related to Melioidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor bindingGO:0051269.9IL15, MIF
2lipopolysaccharide receptor activityGO:0018759.8TLR2, TLR4
3transmembrane signaling receptor activityGO:0048889.7TLR4, TLR2, TLR10, TLR1
4receptor activityGO:0048729.4TLR4, TLR2, TLR1, TREM1, PLAUR
5cytokine activityGO:0051258.7IL18, IL10, IL15, CXCL9, MIF, CSF3

Products for genes affiliated with Melioidosis

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Sources for Melioidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet