MCID: MLD001
MIFTS: 61

Melioidosis malady

Infectious diseases, Immune diseases categories
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Summaries for Melioidosis

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8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection, has material basis in burkholderia pseudomallei, which is transmitted by contact with the contaminated water or soil. the infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.

MalaCards: Melioidosis, also known as acute and fulminating melioidosis, is related to sepsis and pneumonia, and has symptoms including stomach pain, respiratory distress and chest pain. An important gene associated with Melioidosis is TLR5 (toll-like receptor 5), and among its related pathways are IL-17 Family Signaling Pathways and Development Slit Robo signaling. The compounds asialo gm1 and arabinogalactan have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and skin, and related mouse phenotypes are adipose tissue and liver/biliary system.

CDC:4 Melioidosis, also called Whitmore's disease, is an infectious disease that can infect humans or animals. The disease is caused by the bacterium Burkholderia pseudomallei.

Wikipedia:65 Melioidosis is an infectious disease caused by a Gram-negative bacterium, Burkholderia pseudomallei,... more...

Aliases & Classifications for Melioidosis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Immune diseases


Aliases & Descriptions:

melioidosis 8 10 45 62
acute and fulminating melioidosis 8
subacute and chronic melioidosis 8
nightcliff gardener's disease 8
melioidosis, unspecified 8
epizootic lymphangitis 62
whitmore's disease 8
pseudoglanders 8


External Ids:

Disease Ontology8 DOID:5052
ICD9CM27 025
MeSH35 D008554

Related Diseases for Melioidosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Melioidosis:



Diseases related to melioidosis

Symptoms for Melioidosis

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8Disease Ontology
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Symptoms:

8
  • stomach pain
  • respiratory distress
  • chest pain
  • fever

Drugs & Therapeutics for Melioidosis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Melioidosis

Search NIH Clinical Center for Melioidosis

Genetic Tests for Melioidosis

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Anatomical Context for Melioidosis

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33MalaCards
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MalaCards organs/tissues related to Melioidosis:

33
Bone, Lung, Skin, Testes, Liver, Prostate, T cells, Whole blood, Breast, Monocytes, Endothelial, Myeloid, Kidney, Spleen, Spinal cord, Brain

Animal Models for Melioidosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Melioidosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0TLR5, TLR4, TLR2
2MP:00053708.9TLR2, TLR4, TLR5
3MP:00053818.9TLR5, TLR4, TLR2
4MP:00053888.6TLR2, TLR4, TLR5
5MP:00053978.5TLR2, TLR4, TLR5, IRAK3
6MP:00053878.4IRAK3, TLR5, TLR4, TLR2
7MP:00053788.3IRAK3, TLR5, TLR4, TLR2

Publications for Melioidosis

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52PubMed
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Articles related to Melioidosis:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
The Role of NOD2 in Murine and Human Melioidosis. (24298015)
2014
2
Induction of mouse melioidosis with meningitis by CD11b+ phagocytic cells harboring intracellular B. pseudomallei as a Trojan horse. (23951382)
2013
3
Melioidosis: refining management of a tropical time bomb. (24284288)
2013
4
Antimicrobial Prophylaxis For Melioidosis and Leptospirosis For At Risk Rescue Workers. (23466779)
2013
5
Melioidosis from contaminated bore water and successful UV sterilization. (23751401)
2013
6
Melioidosis as a consequence of sporting activity. (23732257)
2013
7
Expect the unexpected: pleuro-pulmonary melioidosis in a renal transplant recipient. (23278969)
2013
8
Clinically lesser known entity in India: A Report of two cases of Melioidosis. (23833477)
2013
9
Activities of daily living associated with acquisition of melioidosis in northeast Thailand: a matched case-control study. (23437412)
2013
10
Melioidosis breast abscesses. (22285589)
2012
11
Melioidosis in animals, Thailand, 2006-2010. (22304782)
2012
12
Outbreak of melioidosis and leptospirosis co-infection following a rescue operation. (23082420)
2012
13
Development of hydrolysis probe-based real-time PCR for identification of virulent gene targets of Burkholderia pseudomallei and B. mallei--a retrospective study on archival cases of service members with melioidosis and glanders. (22360070)
2012
14
Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders. (22912938)
2012
15
BLF1, the first Burkholderia pseudomallei toxin, connects inhibition of host protein synthesis with melioidosis. (22817745)
2012
16
Imported melioidosis in France revealed by a cracking abdominal mycotic aortic aneurysm in a 61-year-old man. (22962397)
2012
17
Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis. (20837078)
2010
18
Radiological manifestations of melioidosis. (20103424)
2010
19
Imported melioidosis in Danish travellers: a diagnostic challenge. (20297927)
2010
20
Burkholderia thailandensis whole cell antigen cross-reacts with B. pseudomallei antibodies from patients with melioidosis in an immunofluorescent assay. (20578523)
2010
21
Defining the true sensitivity of culture for the diagnosis of melioidosis using Bayesian latent class models. (20830194)
2010
22
Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis. (19903332)
2009
23
The molecular and cellular basis of pathogenesis in melioidosis: how does Burkholderia pseudomallei cause disease? (19732156)
2009
24
Melioidosis in a tropical city state, Singapore. (19861063)
2009
25
Non-septicemic melioidosis presenting as cardiac tamponade. (18784243)
2008
26
Rheumatological manifestations in patients with melioidosis. (19058601)
2008
27
Cases of melioidosis in a university teaching hospital in Malaysia. (18473106)
2008
28
Melioidosis--an unusual cause of septic arthritis. (18506568)
2008
29
Evaluation of recombinant antigens for diagnosis of melioidosis. (18657105)
2008
30
Serum C-reactive protein and liver disease in patients with melioidosis. (17262186)
2007
31
Misdiagnosing melioidosis. (17479916)
2007
32
Melioidosis outbreak after typhoon, southern Taiwan. (17553230)
2007
33
Melioidosis: an under-diagnosed entity in western coastal India: a clinico-microbiological analysis. (17901643)
2007
34
Accuracy of enzyme-linked immunosorbent assay using crude and purified antigens for serodiagnosis of melioidosis. (17093104)
2007
35
Melioidosis and rainfall in Kuala Lumpur, Malaysia. (16965821)
2007
36
Role of selective and nonselective media for isolation of Burkholderia pseudomallei from throat swabs of patients with melioidosis. (16757651)
2006
37
Imported melioidosis--South Florida, 2005. (16915220)
2006
38
Fatal septicemic melioidosis in a young military person possibly co-infected with Leptospira interrogans and Orientia tsutsugamushi. (15909673)
2005
39
Melioidosis of the spleen diagnosed by 16S rDNA amplification and sequencing. (16012017)
2005
40
Antibodies from patients with melioidosis recognize Burkholderia mallei but not Burkholderia thailandensis antigens in the indirect hemagglutination assay. (16145163)
2005
41
Melioidosis in Pahang, Malaysia. (16515112)
2005
42
Melioidosis and the vascular surgeon: Hospital Kuala Lumpur experience. (16234087)
2005
43
Clinical presentation of melioidosis in Queensland, Australia. (16111729)
2005
44
Melioidosis in animals: a review on epizootiology, diagnosis and clinical presentation. (15525357)
2004
45
Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei. (12734250)
2003
46
Melioidosis presenting as an infected intrathoracic subclavian artery pseudoaneurysm treated with femoral vein interposition graft. (11877708)
2002
47
Melioidosis vaccines. (12901586)
2002
48
Cutaneous melioidosis. (12139670)
2002
49
Randomized, double-blind, controlled study of cefoperazone-sulbactam plus cotrimoxazole versus ceftazidime plus cotrimoxazole for the treatment of severe melioidosis. (11389491)
2001
50
Immune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein. (1902247)
1991

Variations for Melioidosis

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Expression for genes affiliated with Melioidosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Melioidosis

Search GEO for disease gene expression data for Melioidosis.

Pathways for genes affiliated with Melioidosis

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Sources:
50PathCards, 54R&D Systems, 38NCBI BioSystems Database, 60Thomson Reuters, 12EMD Millipore, 30KEGG, 53QIAGEN, 55Reactome, 5Cell Signaling Technology, 61Tocris Bioscience, 57SinoBiological
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Pathways related to Melioidosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5TLR2, TLR5
2
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection38
9.4TLR4, TLR5
3
Show member pathways
9.4TLR4, TLR5
4
Show member pathways
9.3TLR4, TLR2
59.3TLR2, TLR4
69.3TLR4, TLR2
79.3TLR2, TLR4
89.3TLR4, TLR2
99.3TLR4, TLR2
109.3TLR4, TLR2
11
Show member pathways
9.3IRAK3, TLR4
12
Show member pathways
Immune response MIF in innate immunity response60
9.3TLR4, IRAK3
138.9TLR2, TLR5, TLR4
14
Show member pathways
8.9TLR5, TLR4, TLR2
15
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.9TLR5, TLR4, TLR2
168.8TLR2, IRAK3, TLR4
17
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.4TLR4, TLR2, TLR5, IRAK3
188.1TLR10, TLR2, TLR4, TLR5
19
Show member pathways
8.1TLR2, TLR5, TLR4, TLR10
20
Show member pathways
IL27-mediated signaling events38
8.1TLR10, TLR2, TLR4, TLR5
21
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.1TLR5, TLR4, TLR2, TLR10
22
Show member pathways
8.1TLR4, TLR2, TLR5, TLR10
238.1TLR10, TLR5, TLR4, TLR2
24
Show member pathways
8.1TLR5, TLR10, TLR2, TLR4
25
Show member pathways
7.5TLR10, TLR2, TLR4, TLR5, IRAK3
26
Show member pathways
7.5IRAK3, TLR5, TLR4, TLR2, TLR10
27
Show member pathways
7.5TLR4, TLR10, IRAK3, TLR2, TLR5
28
Show member pathways
7.5TLR10, TLR2, TLR4, TLR5, IRAK3

Compounds for genes affiliated with Melioidosis

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB
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Compounds related to Melioidosis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1asialo gm1459.9TLR5, TLR2
2arabinogalactan459.7TLR4, TLR2
3diaminopimelic acid459.7TLR2, TLR4
4pam2csk4619.7TLR2, TLR4
5pam3csk4619.7TLR2, TLR4
6poly(i:c)619.7TLR2, TLR4
7glucuronoxylomannan459.7TLR4, TLR2
8resiquimod45 6110.7TLR4, TLR2
9muramyl dipeptide45 2910.7TLR4, TLR2
10hbd2459.7TLR4, TLR2
11lauric acid45 2910.7TLR2, TLR4
12zymosan459.7TLR4, TLR2
13imiquimod45 61 29 1112.7TLR4, TLR2
14mannan459.6TLR2, TLR4
15docosahexaenoic acid45 29 2411.6TLR4, TLR2
16polymyxin b459.6TLR2, TLR4
17polyinosinic-polycytidylic acid459.6TLR4, TLR2
18il 10459.6TLR4, TLR2
19glycolipid459.6TLR2, TLR4
20anti-fungal459.6TLR4, TLR2
21ccl345 2910.6TLR2, TLR4
22latex459.5TLR4, TLR2
23palmitate459.5TLR4, TLR2
24agarose459.4TLR4, TLR2
25simvastatin45 51 61 29 24 1114.3TLR4, TLR2
26calcitriol45 61 24 1112.3TLR4, TLR2
27loxoribine45 2910.3TLR5, TLR4, TLR2
28flagellin45 2910.3TLR5, TLR4, TLR2
29lipoteichoic acid459.3TLR2, TLR4, TLR5
30poly(i-c)459.3TLR5, TLR4, TLR2
31peptidoglycan45 2910.3TLR2, TLR4, TLR5
32mannose459.2TLR2, TLR4
33rantes459.2TLR5, TLR4, TLR2
34endotoxin459.2TLR2, TLR4, IRAK3
35phosphatidylinositol459.1TLR5, TLR4, TLR2
36tacrolimus45 51 1111.0TLR4, TLR2
37atp45 2910.0TLR2, TLR4, TLR5

GO Terms for genes affiliated with Melioidosis

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16Gene Ontology
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Cellular components related to Melioidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3TLR4, TLR2

Biological processes related to Melioidosis according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of toll-like receptor signaling pathwayGO:0341239.9TLR2, TLR5
2negative regulation of interleukin-12 productionGO:0326959.8IRAK3, TLR2
3positive regulation of macrophage cytokine productionGO:0609079.7TLR4, TLR2
4cellular response to lipoteichoic acidGO:0712239.7TLR4, TLR2
5negative regulation of interleukin-17 productionGO:0327009.7TLR2, TLR4
6positive regulation of tumor necrosis factor biosynthetic processGO:0425359.7TLR4, TLR2
7positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.7TLR2, TLR4
8I-kappaB phosphorylationGO:0072529.7TLR2, TLR4
9positive regulation of chemokine productionGO:0327229.7TLR4, TLR2
10positive regulation of interleukin-10 productionGO:0327339.7TLR4, TLR2
11positive regulation of NF-kappaB import into nucleusGO:0423469.7TLR2, TLR4
12negative regulation of interleukin-6 productionGO:0327159.7IRAK3, TLR4
13positive regulation of interferon-beta productionGO:0327289.7TLR4, TLR2
14positive regulation of interleukin-12 productionGO:0327359.6TLR4, TLR2
15lipopolysaccharide-mediated signaling pathwayGO:0316639.6TLR2, TLR4
16negative regulation of tumor necrosis factor productionGO:0327209.6IRAK3, TLR4
17positive regulation of nitric oxide biosynthetic processGO:0454299.6TLR4, TLR2
18positive regulation of tumor necrosis factor productionGO:0327609.6TLR2, TLR4
19positive regulation of interleukin-6 productionGO:0327559.6TLR4, TLR2
20cellular response to mechanical stimulusGO:0712609.5TLR5, TLR4
21toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.4TLR2, TLR4
22toll-like receptor 10 signaling pathwayGO:0341669.4TLR10, TLR5
23cellular response to lipopolysaccharideGO:0712229.4TLR5, TLR4
24toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.4TLR2, TLR4
25toll-like receptor 5 signaling pathwayGO:0341469.4TLR10, TLR5
26response to lipopolysaccharideGO:0324969.3IRAK3, TLR4
27positive regulation of interleukin-8 productionGO:0327579.3TLR2, TLR4, TLR5
28toll-like receptor 2 signaling pathwayGO:0341349.2TLR2, TLR4
29positive regulation of NF-kappaB transcription factor activityGO:0510929.2TLR2, TLR4, IRAK3
30toll-like receptor 4 signaling pathwayGO:0341429.0TLR4, TLR2
31inflammatory responseGO:0069549.0TLR10, TLR2, TLR5
32positive regulation of inflammatory responseGO:0507298.9TLR4, TLR2, TLR10
33immune responseGO:0069558.8TLR4, TLR2, TLR10
34toll-like receptor signaling pathwayGO:0022248.5TLR10, TLR2, TLR4, TLR5
35innate immune responseGO:0450878.4TLR5, TLR4, TLR2, TLR10
36MyD88-dependent toll-like receptor signaling pathwayGO:0027557.9IRAK3, TLR5, TLR4, TLR2, TLR10

Molecular functions related to Melioidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:0018759.0TLR4, TLR2
2transmembrane signaling receptor activityGO:0048888.5TLR4, TLR2, TLR10

Products for genes affiliated with Melioidosis

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  • Antibodies
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Sources for Melioidosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet