MCID: MLD001
MIFTS: 62

Melioidosis malady

Infectious diseases, Rare diseases categories

Aliases & Classifications for Melioidosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 2CDC, 61UMLS, 56SNOMED-CT, 33MeSH, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Melioidosis:

Name: Melioidosis 8 10 44 48 2 61
Whitmore's Disease 8 2
Acute and Fulminating Melioidosis 8
Subacute and Chronic Melioidosis 8
 
Nightcliff Gardener's Disease 8
Melioidosis, Unspecified 8
Pseudoglanders 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
melioidosis:
Age of onset: All ages


External Ids:

Disease Ontology8 DOID:5052
MeSH33 D008554
ICD9CM27 025
Orphanet48 31202
MESH via Orphanet34 D008554
ICD10 via Orphanet26 A24.1, A24.2, A24.3 A24.4, more
UMLS via Orphanet62 C0025229

Summaries for Melioidosis

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Disease Ontology:8 A primary bacterial infectious disease that results in infection, has material basis in burkholderia pseudomallei, which is transmitted by contact with the contaminated water or soil. the infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.

MalaCards based summary: Melioidosis, also known as whitmore's disease, is related to pneumonia and systemic lupus erythematosus, and has symptoms including fever, respiratory distress and chest pain. An important gene associated with Melioidosis is TLR5 (toll-like receptor 5), and among its related pathways are IL-17 Family Signaling Pathways and Development Slit Robo signaling. The compounds asialo gm1 and arabinogalactan have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skeletal muscle and bone, and related mouse phenotypes are adipose tissue and liver/biliary system.

Wikipedia:64 Melioidosis is an infectious disease caused by a gram-negative bacterium, Burkholderia pseudomallei,... more...

Related Diseases for Melioidosis

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Graphical network of the top 20 diseases related to Melioidosis:



Diseases related to melioidosis

Symptoms for Melioidosis

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Symptoms:

 8
  • fever
  • respiratory distress
  • chest pain
  • stomach pain

Drugs & Therapeutics for Melioidosis

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Drug clinical trials:

Search ClinicalTrials for Melioidosis

Search NIH Clinical Center for Melioidosis

Genetic Tests for Melioidosis

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Anatomical Context for Melioidosis

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MalaCards organs/tissues related to Melioidosis:

31
Spinal cord, Skeletal muscle, Bone, Lung, Skin, T cells, Liver, B cells, Breast, Kidney, Testes, Thyroid, Testis, Prostate, Whole blood, Spleen, Brain, Myeloid, Monocytes, Endothelial, Neutrophil

Animal Models for Melioidosis or affiliated genes

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MGI Mouse Phenotypes related to Melioidosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0TLR5, TLR4, TLR2
2MP:00053708.9TLR2, TLR4, TLR5
3MP:00053818.9TLR5, TLR4, TLR2
4MP:00053888.6TLR2, TLR4, TLR5
5MP:00053978.5TLR2, TLR4, TLR5, IRAK3
6MP:00053878.4IRAK3, TLR5, TLR4, TLR2
7MP:00053788.3IRAK3, TLR5, TLR4, TLR2

Publications for Melioidosis

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Articles related to Melioidosis:

(show top 50)    (show all 544)
idTitleAuthorsYear
1
Melioidosis: a report of two cases. (25668164)
2014
2
The Role of NOD2 in Murine and Human Melioidosis. (24298015)
2014
3
Induction of mouse melioidosis with meningitis by CD11b+ phagocytic cells harboring intracellular B. pseudomallei as a Trojan horse. (23951382)
2013
4
Melioidosis: refining management of a tropical time bomb. (24284288)
2013
5
Antimicrobial Prophylaxis For Melioidosis and Leptospirosis For At Risk Rescue Workers. (23466779)
2013
6
Melioidosis from contaminated bore water and successful UV sterilization. (23751401)
2013
7
Melioidosis as a consequence of sporting activity. (23732257)
2013
8
Expect the unexpected: pleuro-pulmonary melioidosis in a renal transplant recipient. (23278969)
2013
9
Melioidosis and idiopathic pulmonary hemosiderosis: a cast-iron case. (25473541)
2013
10
Melioidosis breast abscesses. (22285589)
2012
11
Melioidosis in animals, Thailand, 2006-2010. (22304782)
2012
12
Outbreak of melioidosis and leptospirosis co-infection following a rescue operation. (23082420)
2012
13
Development of hydrolysis probe-based real-time PCR for identification of virulent gene targets of Burkholderia pseudomallei and B. mallei--a retrospective study on archival cases of service members with melioidosis and glanders. (22360070)
2012
14
Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders. (22912938)
2012
15
BLF1, the first Burkholderia pseudomallei toxin, connects inhibition of host protein synthesis with melioidosis. (22817745)
2012
16
Imported melioidosis in France revealed by a cracking abdominal mycotic aortic aneurysm in a 61-year-old man. (22962397)
2012
17
Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis. (20837078)
2010
18
Radiological manifestations of melioidosis. (20103424)
2010
19
Imported melioidosis in Danish travellers: a diagnostic challenge. (20297927)
2010
20
Burkholderia thailandensis whole cell antigen cross-reacts with B. pseudomallei antibodies from patients with melioidosis in an immunofluorescent assay. (20578523)
2010
21
Defining the true sensitivity of culture for the diagnosis of melioidosis using Bayesian latent class models. (20830194)
2010
22
Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis. (19903332)
2009
23
The molecular and cellular basis of pathogenesis in melioidosis: how does Burkholderia pseudomallei cause disease? (19732156)
2009
24
Melioidosis in a tropical city state, Singapore. (19861063)
2009
25
Non-septicemic melioidosis presenting as cardiac tamponade. (18784243)
2008
26
Rheumatological manifestations in patients with melioidosis. (19058601)
2008
27
Cases of melioidosis in a university teaching hospital in Malaysia. (18473106)
2008
28
Melioidosis--an unusual cause of septic arthritis. (18506568)
2008
29
Evaluation of recombinant antigens for diagnosis of melioidosis. (18657105)
2008
30
Serum C-reactive protein and liver disease in patients with melioidosis. (17262186)
2007
31
Misdiagnosing melioidosis. (17479916)
2007
32
Melioidosis outbreak after typhoon, southern Taiwan. (17553230)
2007
33
Melioidosis: an under-diagnosed entity in western coastal India: a clinico-microbiological analysis. (17901643)
2007
34
Accuracy of enzyme-linked immunosorbent assay using crude and purified antigens for serodiagnosis of melioidosis. (17093104)
2007
35
Melioidosis and rainfall in Kuala Lumpur, Malaysia. (16965821)
2007
36
Role of selective and nonselective media for isolation of Burkholderia pseudomallei from throat swabs of patients with melioidosis. (16757651)
2006
37
Imported melioidosis--South Florida, 2005. (16915220)
2006
38
Fatal septicemic melioidosis in a young military person possibly co-infected with Leptospira interrogans and Orientia tsutsugamushi. (15909673)
2005
39
Melioidosis of the spleen diagnosed by 16S rDNA amplification and sequencing. (16012017)
2005
40
Antibodies from patients with melioidosis recognize Burkholderia mallei but not Burkholderia thailandensis antigens in the indirect hemagglutination assay. (16145163)
2005
41
Melioidosis in Pahang, Malaysia. (16515112)
2005
42
Melioidosis and the vascular surgeon: Hospital Kuala Lumpur experience. (16234087)
2005
43
Clinical presentation of melioidosis in Queensland, Australia. (16111729)
2005
44
Melioidosis in animals: a review on epizootiology, diagnosis and clinical presentation. (15525357)
2004
45
Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei. (12734250)
2003
46
Melioidosis presenting as an infected intrathoracic subclavian artery pseudoaneurysm treated with femoral vein interposition graft. (11877708)
2002
47
Melioidosis vaccines. (12901586)
2002
48
Cutaneous melioidosis. (12139670)
2002
49
Randomized, double-blind, controlled study of cefoperazone-sulbactam plus cotrimoxazole versus ceftazidime plus cotrimoxazole for the treatment of severe melioidosis. (11389491)
2001
50
Immune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein. (1902247)
1991

Variations for Melioidosis

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Expression for genes affiliated with Melioidosis

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LifeMap Discovery
Genes differentially expressed in tissues of Melioidosis patients vs. healthy controls: 30 (show all 73)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptideBlood-6.000.000
2LRRN3leucine rich repeat neuronal 3Blood-5.510.000
3GAPDHglyceraldehyde-3-phosphate dehydrogenaseSkeletal Muscle-5.090.006
4NOVnephroblastoma overexpressedBlood-4.840.000
5PLVAPplasmalemma vesicle associated proteinBlood-4.760.000
6RPGRIP1retinitis pigmentosa GTPase regulator interacting protein 1Blood-4.670.000
7SLNsarcolipinSkeletal Muscle-4.640.007
8CACNA2D3calcium channel, voltage-dependent, alpha 2/delta subunit 3Blood-4.250.000
9HBDhemoglobin, deltaBlood+4.090.000
10LTFlactotransferrinBlood+3.940.000
11LGALSLlectin, galactoside-binding-likeBlood-3.810.000
12NELL2NEL-like 2 (chicken)Blood-3.790.000
13ELOVL4ELOVL fatty acid elongase 4Blood-3.760.000
14ALAS2aminolevulinate, delta-, synthase 2Blood+3.750.000
15BOD1L1biorientation of chromosomes in cell division 1-like 1Blood+3.720.000
16FBXO11F-box protein 11Spinal Cord+3.700.005
17MALAT1metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)Blood+3.690.000
18KIAA1671KIAA1671Blood-3.680.000
19PTGDR2prostaglandin D2 receptor 2Blood-3.680.000
20IL5RAinterleukin 5 receptor, alphaBlood-3.660.000
21PTGDRprostaglandin D2 receptor (DP)Blood-3.630.000
22CD160CD160 moleculeBlood-3.620.000
23CPT1Acarnitine palmitoyltransferase 1A (liver)Spinal Cord+3.620.004
24GCATglycine C-acetyltransferaseBlood-3.580.000
25CLEC4CC-type lectin domain family 4, member CBlood-3.550.000
26CD248CD248 molecule, endosialinBlood-3.550.000
27PLEKHG4pleckstrin homology domain containing, family G (with RhoGef domain) member 4Blood-3.530.000
28HDChistidine decarboxylaseBlood-3.520.000
29PID1phosphotyrosine interaction domain containing 1Blood-3.500.000
30CD3DCD3d molecule, delta (CD3-TCR complex)Blood-3.480.000
31SUPT3Hsuppressor of Ty 3 homolog (S. cerevisiae)Blood-3.430.000
32LGALS2lectin, galactoside-binding, soluble, 2Blood-3.420.000
33CLEC4AC-type lectin domain family 4, member ASpinal Cord+3.410.016
34KLHL3kelch-like family member 3Blood-3.400.000
35SPINK2serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)Blood-3.400.000
36OLIG2oligodendrocyte lineage transcription factor 2Blood-3.390.000
37SAMSN1SAM domain, SH3 domain and nuclear localization signals 1Blood+3.390.000
38DBPD site of albumin promoter (albumin D-box) binding proteinBlood-3.380.000
39PRSS23protease, serine, 23Blood-3.380.000
40NT5E5'-nucleotidase, ecto (CD73)Blood-3.360.000
41ZNF69zinc finger protein 69Blood-3.350.000
42PUS7pseudouridylate synthase 7 (putative)Spinal Cord+3.340.038
43SLC2A10solute carrier family 2 (facilitated glucose transporter), member 10Spinal Cord+3.330.006
44DNASE1L3deoxyribonuclease I-like 3Blood-3.310.000
45FHITfragile histidine triadBlood-3.310.000
46GSTM1glutathione S-transferase mu 1Blood-3.290.000
47SIGLEC17Psialic acid binding Ig-like lectin 17, pseudogeneBlood-3.240.000
48HLA-DQB1major histocompatibility complex, class II, DQ beta 1Blood-3.240.000
49OLFM1olfactomedin 1Blood-3.230.000
50EDARectodysplasin A receptorBlood-3.210.000
51CLCCharcot-Leyden crystal galectinBlood+3.200.000
52DTX3deltex 3, E3 ubiquitin ligaseBlood-3.190.000
53VIPR1vasoactive intestinal peptide receptor 1Blood-3.170.000
54ENKURenkurin, TRPC channel interacting proteinBlood-3.150.000
55CCDC65coiled-coil domain containing 65Blood-3.150.000
56FBLN2fibulin 2Blood-3.150.000
57HBMhemoglobin, muBlood+3.150.000
58CPA3carboxypeptidase A3 (mast cell)Blood-3.140.000
59CD1CCD1c moleculeBlood-3.120.000
60CD8BCD8b moleculeBlood-3.120.000
61LYRM4LYR motif containing 4Blood-3.100.000
62EPHA4EPH receptor A4Blood-3.090.000
63CCR3chemokine (C-C motif) receptor 3Blood-3.090.000
64SFTPDsurfactant protein DBlood-3.090.000
65SELMselenoprotein MBlood-3.070.000
66CAB39Lcalcium binding protein 39-likeSpinal Cord+3.070.000
67KLRC3killer cell lectin-like receptor subfamily C, member 3Blood-3.050.000
68IGHDimmunoglobulin heavy constant deltaBlood+3.050.000
69EPHB1EPH receptor B1Blood-3.040.000
70LDLRAD4low density lipoprotein receptor class A domain containing 4Blood-3.030.000
71TGFBItransforming growth factor, beta-induced, 68kDaBlood-3.020.000
72NHSNance-Horan syndrome (congenital cataracts and dental anomalies)Blood-3.010.000
73CABP5calcium binding protein 5Blood-3.000.000

Search GEO for disease gene expression data for Melioidosis.

Pathways for genes affiliated with Melioidosis

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Pathways related to Melioidosis according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5TLR2, TLR5
2
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion59
Pathogenic Escherichia coli infection36
Cytoskeleton remodeling Slit Robo signaling
9.4TLR4, TLR5
3
Show member pathways
9.4TLR4, TLR5
4
Show member pathways
9.3TLR4, TLR2
59.3TLR2, TLR4
69.3TLR4, TLR2
79.3TLR2, TLR4
89.3TLR4, TLR2
99.3TLR4, TLR2
109.3TLR4, TLR2
11
Show member pathways
9.3IRAK3, TLR4
12
Show member pathways
Immune response MIF in innate immunity response59
9.3TLR4, IRAK3
138.9TLR2, TLR5, TLR4
14
Show member pathways
8.9TLR5, TLR4, TLR2
15
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.9TLR5, TLR4, TLR2
168.8TLR2, IRAK3, TLR4
17
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
8.4TLR4, TLR2, TLR5, IRAK3
188.1TLR10, TLR2, TLR4, TLR5
19
Show member pathways
8.1TLR2, TLR5, TLR4, TLR10
20
Show member pathways
IL27-mediated signaling events36
8.1TLR10, TLR2, TLR4, TLR5
21
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.1TLR5, TLR4, TLR2, TLR10
22
Show member pathways
8.1TLR4, TLR2, TLR5, TLR10
238.1TLR10, TLR5, TLR4, TLR2
24
Show member pathways
8.1TLR5, TLR10, TLR2, TLR4
25
Show member pathways
7.5TLR10, TLR2, TLR4, TLR5, IRAK3
26
Show member pathways
7.5IRAK3, TLR5, TLR4, TLR2, TLR10
27
Show member pathways
7.5TLR4, TLR10, IRAK3, TLR2, TLR5
28
Show member pathways
7.5TLR10, TLR2, TLR4, TLR5, IRAK3

Compounds for genes affiliated with Melioidosis

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Compounds related to Melioidosis according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1asialo gm1449.9TLR2, TLR5
2arabinogalactan449.7TLR4, TLR2
3diaminopimelic acid449.7TLR4, TLR2
4poly(i:c)609.7TLR2, TLR4
5pam2csk4609.7TLR2, TLR4
6pam3csk4609.7TLR2, TLR4
7glucuronoxylomannan449.7TLR2, TLR4
8resiquimod44 6010.7TLR4, TLR2
9muramyl dipeptide44 2810.7TLR4, TLR2
10hbd2449.7TLR2, TLR4
11lauric acid44 2810.7TLR2, TLR4
12zymosan449.7TLR2, TLR4
13imiquimod44 60 28 1112.7TLR2, TLR4
14mannan449.6TLR2, TLR4
15docosahexaenoic acid44 28 2411.6TLR4, TLR2
16polymyxin b449.6TLR4, TLR2
17polyinosinic-polycytidylic acid449.6TLR4, TLR2
18il 10449.6TLR2, TLR4
19glycolipid449.6TLR2, TLR4
20anti-fungal449.6TLR4, TLR2
21ccl344 2810.6TLR2, TLR4
22latex449.5TLR4, TLR2
23palmitate449.5TLR4, TLR2
24agarose449.4TLR4, TLR2
25simvastatin44 50 60 28 24 1114.3TLR2, TLR4
26calcitriol44 60 24 1112.3TLR2, TLR4
27loxoribine44 2810.3TLR4, TLR2, TLR5
28flagellin44 2810.3TLR5, TLR2, TLR4
29lipoteichoic acid449.3TLR5, TLR2, TLR4
30poly(i-c)449.3TLR5, TLR4, TLR2
31peptidoglycan44 2810.3TLR2, TLR5, TLR4
32mannose449.2TLR4, TLR2
33rantes449.2TLR5, TLR4, TLR2
34endotoxin449.2TLR4, IRAK3, TLR2
35phosphatidylinositol449.1TLR4, TLR5, TLR2
36tacrolimus44 50 1111.0TLR4, TLR2
37atp44 2810.0TLR5, TLR4, TLR2

GO Terms for genes affiliated with Melioidosis

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Cellular components related to Melioidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.3TLR4, TLR2

Biological processes related to Melioidosis according to GeneCards Suite gene sharing:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of toll-like receptor signaling pathwayGO:00341239.9TLR2, TLR5
2negative regulation of interleukin-12 productionGO:00326959.8IRAK3, TLR2
3cellular response to lipoteichoic acidGO:00712239.7TLR4, TLR2
4positive regulation of macrophage cytokine productionGO:00609079.7TLR2, TLR4
5negative regulation of interleukin-17 productionGO:00327009.7TLR4, TLR2
6positive regulation of tumor necrosis factor biosynthetic processGO:00425359.7TLR2, TLR4
7I-kappaB phosphorylationGO:00072529.7TLR4, TLR2
8positive regulation of nitric-oxide synthase biosynthetic processGO:00517709.7TLR2, TLR4
9positive regulation of chemokine productionGO:00327229.7TLR4, TLR2
10positive regulation of interleukin-10 productionGO:00327339.7TLR2, TLR4
11positive regulation of NF-kappaB import into nucleusGO:00423469.7TLR2, TLR4
12negative regulation of interleukin-6 productionGO:00327159.7TLR4, IRAK3
13positive regulation of interferon-beta productionGO:00327289.7TLR2, TLR4
14positive regulation of interleukin-12 productionGO:00327359.6TLR4, TLR2
15lipopolysaccharide-mediated signaling pathwayGO:00316639.6TLR2, TLR4
16positive regulation of nitric oxide biosynthetic processGO:00454299.6TLR4, TLR2
17negative regulation of tumor necrosis factor productionGO:00327209.6IRAK3, TLR4
18positive regulation of tumor necrosis factor productionGO:00327609.6TLR2, TLR4
19positive regulation of interleukin-6 productionGO:00327559.6TLR4, TLR2
20cellular response to mechanical stimulusGO:00712609.5TLR5, TLR4
21toll-like receptor TLR6:TLR2 signaling pathwayGO:00381249.4TLR4, TLR2
22cellular response to lipopolysaccharideGO:00712229.4TLR5, TLR4
23toll-like receptor TLR1:TLR2 signaling pathwayGO:00381239.4TLR4, TLR2
24toll-like receptor 5 signaling pathwayGO:00341469.4TLR5, TLR10
25toll-like receptor 10 signaling pathwayGO:00341669.4TLR5, TLR10
26response to lipopolysaccharideGO:00324969.3TLR4, IRAK3
27positive regulation of interleukin-8 productionGO:00327579.3TLR4, TLR5, TLR2
28toll-like receptor 2 signaling pathwayGO:00341349.2TLR2, TLR4
29positive regulation of NF-kappaB transcription factor activityGO:00510929.2TLR2, TLR4, IRAK3
30toll-like receptor 4 signaling pathwayGO:00341429.0TLR2, TLR4
31inflammatory responseGO:00069549.0TLR2, TLR10, TLR5
32positive regulation of inflammatory responseGO:00507298.9TLR2, TLR4, TLR10
33immune responseGO:00069558.8TLR4, TLR2, TLR10
34toll-like receptor signaling pathwayGO:00022248.5TLR10, TLR5, TLR2, TLR4
35innate immune responseGO:00450878.4TLR4, TLR2, TLR5, TLR10
36MyD88-dependent toll-like receptor signaling pathwayGO:00027557.9TLR4, TLR10, TLR2, TLR5, IRAK3

Molecular functions related to Melioidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:00018759.0TLR4, TLR2
2transmembrane signaling receptor activityGO:00048888.5TLR4, TLR2, TLR10

Sources for Melioidosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet