MCID: MLD001
MIFTS: 67

Melioidosis malady

Categories: Genetic diseases, Rare diseases, Infectious diseases, Immune diseases

Aliases & Classifications for Melioidosis

Aliases & Descriptions for Melioidosis:

Name: Melioidosis 54 12 50 56 29 52 3 42 14 69
Nightcliff Gardener's Disease 12 50
Whitmore's Disease 12 3
Melioidosis, Susceptibility to Melioidosis, Resistance to, Included 54
Burkholderia Pseudomallei Infection 50
Acute and Fulminating Melioidosis 12
Subacute and Chronic Melioidosis 12
B Pseudomallei Infection 50
Epizootic Lymphangitis 69
Whitmore Disease 50
Pseudoglanders 12

Characteristics:

Orphanet epidemiological data:

56
melioidosis
Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

OMIM 54 615557
Disease Ontology 12 DOID:5052
ICD9CM 35 025
MeSH 42 D008554
Orphanet 56 ORPHA31202
MESH via Orphanet 43 D008554
ICD10 via Orphanet 34 A24.1 A24.2 A24.3 more
UMLS via Orphanet 70 C0025229
UMLS 69 C0025229

Summaries for Melioidosis

NIH Rare Diseases : 50 melioidosis is an infectious disease caused by the bacteria burkholderia pseudomallei that are commonly found in the soil and water. melioidosis is a rare disease in the united states, but it is common in tropical or subtropical areas of the world, including southeast asia, africa, and australia. the signs and symptoms of the disease can vary greatly and may mimic those of tuberculosis or common forms of pneumonia. signs and symptoms may include pain or swelling, fever, abscess, cough, high fever, headache, trouble breathing, and more. although healthy people can also experience signs and symptoms of the disease, people with certain conditions like diabetes, liver disease, kidney disease, lung disease, thalassemia, cancer, or certain autoimmune diseases are more severely affected. diagnosis is made by collecting blood, sputum, urine, or pus samples and growing the bacteria. current treatment is divided into two stages: an intravenous (iv) antibiotic stage and oral antibiotic maintenance stage to prevent recurrence. last updated: 1/13/2016

MalaCards based summary : Melioidosis, also known as nightcliff gardener's disease, is related to hepatitis and polyarteritis nodosa, and has symptoms including fever, respiratory distress and chest pain. An important gene associated with Melioidosis is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Innate Immune System and Activated TLR4 signalling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotypes are Decreased viability in esophageal squamous lineage and hematopoietic system

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection, has material basis in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.

OMIM : 54 Melioidosis is infection caused by the gram-negative, flagellated soil saprophyte Burkholderia pseudomallei, which is... (615557) more...

CDC : 3 Melioidosis, also called Whitmore's disease, is an infectious disease that can infect humans or animals. The disease is caused by the bacterium Burkholderia pseudomallei.

Wikipedia : 71 Melioidosis is an infectious disease caused by a Gram-negative bacterium, Burkholderia pseudomallei,... more...

Related Diseases for Melioidosis

Diseases related to Melioidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)
id Related Disease Score Top Affiliating Genes
1 hepatitis 29.5 IFNG IL10 IL6
2 polyarteritis nodosa 29.5 IFNG TLR2 TLR4
3 pulmonary tuberculosis 29.0 IFNG IL10 IL6 TLR10 TLR4
4 glanders 10.7
5 paralytic poliomyelitis 10.3 IFNG TLR4
6 pseudoainhum 10.2 TLR2 TLR4
7 asymptomatic neurosyphilis 10.2 IFNG IL10
8 hypertensive heart disease 10.2 TLR2 TLR4 TLR5
9 isolated growth hormone deficiency 10.2 IFNG IL18 TLR4
10 spotted fever 10.2 TLR2 TLR4
11 dentin caries 10.2 TLR2 TLR4 TLR5
12 parasitic ichthyosporea infectious disease 10.2 TLR1 TLR2 TLR4
13 odontogenic myxoma 10.2 TLR1 TLR5
14 coronary arterial fistulas 10.2 IL10 TLR4
15 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.1 IFNG IL10
16 tungiasis 10.1 IFNG IL10
17 lateral cystocele 10.1 IL6 TLR1 TLR4
18 parkinson disease 11 10.1 IFNG IL10 TLR4
19 gastric leiomyoma 10.1 IL18 IL6 TLR4
20 red cell phospholipid defect with hemolysis 10.1 IFNG IL18 IL6
21 aortic coarctation 10.1 IL6 TLR2 TLR4
22 ureter inverted papilloma 10.1 IL10 IL6
23 acute myeloid leukemia with recurrent genetic anomaly 10.1 IFNG IL10 IL18
24 neonatal hypoxic and ischemic brain injury 10.1 IL10 IL6
25 nguyen syndrome 10.1 IL10 TLR1 TLR2
26 neuropathy 10.1 IL6 LY96 TLR4
27 microcephaly 10.1 IFNG IL10 TLR2
28 oral cavity carcinoma in situ 10.1 IFNG IL10 TLR2
29 uterine adnexa cancer 10.1 IL6 TLR1 TLR2
30 ectothrix infectious disease 10.1 IFNG TLR1 TLR2 TLR4
31 hyperlucent lung 10.1 IFNG TLR1 TLR2 TLR4
32 leukoplakia of penis 10.1 IL10 IL18 TLR2
33 geniculate ganglionitis 10.1 IFNG IL10 IL18
34 gastroduodenitis 10.1 IFNG IL6 TLR2
35 lepromatous leprosy 10.1 IFNG IL10 IL6
36 cyclosporiasis 10.1 IFNG IL10 IL6
37 unilateral hypoactive labyrinth 10.1 IL10 TLR2 TLR4
38 multiple mitochondrial dysfunctions syndrome 10.1 IFNG IL10 IL6
39 conduct disorder 10.1 IFNG IL10 IL6
40 pancreatic signet ring cell adenocarcinoma 10.1 IFNG IL10 IL6
41 ectodermal dysplasia bartalos type 10.1 IFNG IL10 IL6
42 rift valley fever 10.1 IFNG IL6 TLR4 TLR5
43 histiocytosis 10.1 IL6 TLR2 TLR4
44 hereditary alpha tryptasemia syndrome 10.1 IFNG IL10 IL6
45 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 IL10 IL6 TLR4
46 erb-duchenne and dejerine-klumpke palsies 10.1 IFNG IL10 IL6
47 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.1 IL10 IL6 TLR4
48 plummer's disease 10.0 IFNG IL10 IL6
49 autosomal recessive type iv ehlers-danlos syndrome 10.0 IL10 IL6 TLR4
50 orbital osteomyelitis 10.0 IFNG IL10 IL6

Graphical network of the top 20 diseases related to Melioidosis:



Diseases related to Melioidosis

Symptoms & Phenotypes for Melioidosis

Clinical features from OMIM:

615557

Symptoms:

12
  • fever
  • respiratory distress
  • chest pain
  • stomach pain

GenomeRNAi Phenotypes related to Melioidosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.23 LY96 TLR1 TLR4 TLR5 HABP2 IL18

MGI Mouse Phenotypes related to Melioidosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 IFNG IL10 IL18 IL6 IRAK3 LY96
2 immune system MP:0005387 10.06 IL6 IRAK3 LY96 TLR1 TLR2 TLR4
3 homeostasis/metabolism MP:0005376 10.02 HABP2 IFNG IL10 IL18 IL6 IRAK3
4 cardiovascular system MP:0005385 10 IFNG IL10 IL18 IL6 TLR2 TLR4
5 digestive/alimentary MP:0005381 9.98 TLR2 TLR4 TLR5 IFNG IL10 IL18
6 adipose tissue MP:0005375 9.88 TLR5 IL18 IL6 TLR2 TLR4
7 liver/biliary system MP:0005370 9.8 HABP2 IFNG IL10 IL6 TLR2 TLR4
8 muscle MP:0005369 9.63 IFNG IL10 IL18 IL6 TLR2 TLR4
9 neoplasm MP:0002006 9.35 IFNG IL10 IL6 TLR2 TLR4
10 respiratory system MP:0005388 9.1 IFNG IL10 IL6 TLR2 TLR4 TLR5

Drugs & Therapeutics for Melioidosis

Drugs for Melioidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 4 723-46-6 5329
2
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
3 Anti-Bacterial Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
6 Antimalarials Phase 4
7 Renal Agents Phase 4
8 Antiparasitic Agents Phase 4
9 Antiprotozoal Agents Phase 4
10
Meropenem Approved, Investigational 119478-56-7 64778 441130
11
Ceftazidime Approved 78439-06-2 5481173
12 Thienamycins
13 Pharmaceutical Solutions
14 Immunoglobulins
15 Antibodies

Interventional clinical trials:


id Name Status NCT ID Phase
1 Co-trimoxazole as Maintenance Therapy for Meliodosis Recruiting NCT01420341 Phase 4
2 A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis Unknown status NCT00579956
3 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
4 A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand Recruiting NCT02089152
5 Clinical Presentation of Melioidosis in Head and Neck Region Recruiting NCT03048513
6 Study to Obtain Blood and Voided Urine Samples to Improve the Diagnosis of Melioidosis Recruiting NCT02668406

Search NIH Clinical Center for Melioidosis

Cochrane evidence based reviews: melioidosis

Genetic Tests for Melioidosis

Genetic tests related to Melioidosis:

id Genetic test Affiliating Genes
1 Melioidosis, Susceptibility to 29

Anatomical Context for Melioidosis

MalaCards organs/tissues related to Melioidosis:

39
Lung, Liver, Bone, Skin, Kidney, T Cells, Testes

Publications for Melioidosis

Articles related to Melioidosis:

(show top 50) (show all 649)
id Title Authors Year
1
Anion inhibition profiles of the I^-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei responsible of melioidosis and highly drug resistant to common antibiotics. ( 27914949 )
2017
2
The gut microbiota as a modulator of innate immunity during melioidosis. ( 28422970 )
2017
3
Acute bacteremic pneumonia due to melioidosis developing in the intensive care setting. ( 28417070 )
2017
4
A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-I+ levels in human melioidosis. ( 28475641 )
2017
5
Imported Case of Melioidosis in Oman: Case Report. ( 28042405 )
2017
6
DNA vaccination resurfaces in the struggle against melioidosis. ( 28481716 )
2017
7
Gastrointestinal manifestations of melioidosis: A single center experience. ( 28353081 )
2017
8
Comparison of O-polysaccharide and hemolysin co-regulated protein as target antigens for serodiagnosis of melioidosis. ( 28358816 )
2017
9
Are brucellosis, Q fever and melioidosis potential causes of febrile illness in Madagascar? ( 28502643 )
2017
10
Septicemic Melioidosis with Ruptured Splenic Abscess in a Patient with Thalassemia Intermedia. ( 28250624 )
2017
11
Melioidosis with Portal Vein Thrombosis. ( 28473933 )
2017
12
Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis. ( 28296884 )
2017
13
Functional characterisation of Burkholderia pseudomallei biotin protein ligase: A toolkit for anti-melioidosis drug development. ( 28454708 )
2017
14
Central nervous system melioidosis in the pediatric age group: review. ( 28451778 )
2017
15
Sulfonamide inhibition profile of the I^-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis. ( 28025002 )
2017
16
A case-control study of community-acquired Acinetobacter baumannii pneumonia and melioidosis pneumonia in northeast Thailand: an emerging fatal disease with unique clinical features. ( 27789057 )
2017
17
Melioidosis: Clinical impact and public health threat in the tropics. ( 28493905 )
2017
18
Molecular detection of leptospirosis and melioidosis co-infection: A case report. ( 28330585 )
2017
19
The epidemiology and clinical features of melioidosis in Far North Queensland: Implications for patient management. ( 28264029 )
2017
20
Non-healing chest wall ulcer caused by cutaneous melioidosis. ( 28232013 )
2017
21
Accidental Occupational Exposure to Burkholderia pseudomallei in South Korea Did Not Result in Melioidosis. ( 28414016 )
2017
22
Calprotectin as a Biomarker for Melioidosis Disease Progression and Management. ( 28179407 )
2017
23
Neurological melioidosis presenting as intracranial abscess. ( 27510695 )
2016
24
Identification of CD4+ T-cell epitope and investigation of HLA distribution for the immunogenic proteins of Burkholderia pseudomallei using in silico approaches - A key vaccine development strategy for melioidosis. ( 27086038 )
2016
25
Cutaneous Melioidosis. ( 27790560 )
2016
26
Subcutaneous abscess formation in septic melioidosis, devoid of associated risk factors. ( 27051580 )
2016
27
The antibiotics of choice for the treatment of melioidosis in Indian set up. ( 27514960 )
2016
28
Neonatal Melioidosis with Pneumatoceles. ( 27156557 )
2016
29
Osteomyelitis of Humerus and Intramuscular Abscess Due to Melioidosis. ( 28166079 )
2016
30
Formulation and Characterization of Nanocluster Ceftazidime for the Treatment of Acute Pulmonary Melioidosis. ( 27639659 )
2016
31
Investigation of Recurrent Melioidosis in Lao People's Democratic Republic by Multilocus Sequence Typing. ( 27001759 )
2016
32
Melioidosis in a patient with chronic rhinosinusitis. ( 27488340 )
2016
33
Emerging trends in melioidosis - A case series. ( 27728451 )
2016
34
A rare case of melioidosis presenting as isolated liver abscess. ( 27728711 )
2016
35
Increasing Experience With Melioidosis and Critical Care: Medical and Military Implications. ( 27428122 )
2016
36
Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis. ( 26927094 )
2016
37
A retrospective analysis of melioidosis in Cambodian children, 2009-2013. ( 27871233 )
2016
38
Burkholderia pseudomallei: First case of melioidosis in Portugal. ( 26962474 )
2016
39
Musculoskeletal melioidosis: An under-diagnosed entity in developing countries. ( 26955222 )
2016
40
The association of melioidosis with climatic factors in Darwin, Australia: A 23-year time-series analysis. ( 26945846 )
2016
41
The melioidosis agent Burkholderia pseudomallei and related opportunistic pathogens detected in faecal matter of wildlife and livestock in northern Australia. ( 26935879 )
2016
42
Fatal Melioidosis Infection in a Newborn from Hainan, China. ( 27162267 )
2016
43
Melioidosis in Malaysia: A Review of Case Reports. ( 28005910 )
2016
44
Cutaneous Melioidosis Cluster Caused by Contaminated Wound Irrigation Fluid. ( 27438887 )
2016
45
An 11-Year Analysis of Emergency Presentations of Melioidosis in Northeastern Malaysia. ( 27160769 )
2016
46
Phylogenomic Analysis Reveals an Asian Origin for African Burkholderia pseudomallei and Further Supports Melioidosis Endemicity in Africa. ( 27303718 )
2016
47
Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Impairs Host Defense in Experimental Melioidosis. ( 27253382 )
2016
48
Chronic melioidosis presenting with multiple abscesses. ( 27822380 )
2016
49
Multifocal melioidosis with femoral osteomyelitis in a healthy 25-year-old traveller. ( 27435851 )
2016
50
Melioidosis and glanders modulation of the innate immune system: barriers to current and future vaccine approaches. ( 27010618 )
2016

Variations for Melioidosis

Expression for Melioidosis

LifeMap Discovery
Genes differentially expressed in tissues of Melioidosis patients vs. healthy controls: 35 (show top 50) (show all 181)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CD177 CD177 molecule Blood + 8.41 0.000
2 ZDHHC19 zinc finger, DHHC-type containing 19 Blood + 6.91 0.000
3 MMP8 matrix metallopeptidase 8 Blood + 6.49 0.000
4 SLC51A solute carrier family 51, alpha subunit Blood + 6.46 0.000
5 HP haptoglobin Blood + 6.23 0.000
6 FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide Blood - 6.00 0.000
7 GPR84 G protein-coupled receptor 84 Blood + 5.86 0.000
8 ANKRD22 ankyrin repeat domain 22 Blood + 5.72 0.000
9 OLAH oleoyl-ACP hydrolase Blood + 5.54 0.000
10 LRRN3 leucine rich repeat neuronal 3 Blood - 5.51 0.000
11 PCOLCE2 procollagen C-endopeptidase enhancer 2 Blood + 5.47 0.000
12 C1QC complement component 1, q subcomponent, C chain Blood + 5.42 0.000
13 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Blood + 5.39 0.000
14 CCNA1 cyclin A1 Blood + 5.14 0.000
15 C1QB complement component 1, q subcomponent, B chain Blood + 5.09 0.000
16 LINC00668 long intergenic non-protein coding RNA 668 Blood + 4.99 0.000
17 CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Blood + 4.98 0.000
18 FGF13 fibroblast growth factor 13 Blood + 4.96 0.000
19 NOV nephroblastoma overexpressed Blood - 4.84 0.000
20 PLVAP plasmalemma vesicle associated protein Blood - 4.76 0.000
21 KL klotho Blood + 4.74 0.000
22 SLCO4A1 solute carrier organic anion transporter family, member 4A1 Blood + 4.73 0.000
23 MYO10 myosin X Blood + 4.68 0.000
24 SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 Blood + 4.68 0.000
25 RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 Blood - 4.67 0.000
26 RETN resistin Blood + 4.65 0.000
27 CD274 CD274 molecule Blood + 4.44 0.000
28 MCEMP1 mast cell-expressed membrane protein 1 Blood + 4.44 0.000
29 BMX BMX non-receptor tyrosine kinase Blood + 4.41 0.000
30 SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 Blood + 4.38 0.000
31 CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) Blood + 4.38 0.000
32 GRB10 growth factor receptor-bound protein 10 Blood + 4.37 0.000
33 CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 Blood - 4.25 0.000
34 LINC01220 long intergenic non-protein coding RNA 1220 Blood + 4.20 0.000
35 LTF lactotransferrin Blood + 4.19 0.000
36 SLC26A8 solute carrier family 26 (anion exchanger), member 8 Blood + 4.18 0.000
37 ARG1 arginase 1 Blood + 4.17 0.000
38 IL18R1 interleukin 18 receptor 1 Blood + 4.17 0.000
39 IL1R2 interleukin 1 receptor, type II Blood + 4.08 0.000
40 SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 Blood + 4.06 0.000
41 CFH complement factor H Blood + 4.03 0.000
42 G0S2 G0/G1 switch 2 Blood + 4.02 0.000
43 MMP9 matrix metallopeptidase 9 Blood + 3.97 0.000
44 FCAR Fc fragment of IgA receptor Blood + 3.94 0.000
45 SCN9A sodium channel, voltage gated, type IX alpha subunit Blood + 3.94 0.000
46 FAM20A family with sequence similarity 20, member A Blood + 3.94 0.000
47 KRTAP19-6 keratin associated protein 19-6 Blood + 3.93 0.000
48 TDRD9 tudor domain containing 9 Blood + 3.92 0.000
49 KREMEN1 kringle containing transmembrane protein 1 Blood + 3.86 0.000
50 HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Blood + 3.84 0.000
Search GEO for disease gene expression data for Melioidosis.

Pathways for Melioidosis

Pathways related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 IFNG IL10 IL18 IL6 IRAK3 LY96
2
Show member pathways
13.52 IRAK3 LY96 TLR1 TLR10 TLR2 TLR4
3
Show member pathways
13.39 IL10 IL18 IL6 IRAK3 TLR1 TLR10
4
Show member pathways
13.17 IFNG IRAK3 TLR1 TLR10 TLR2 TLR4
5
Show member pathways
12.95 IL18 IL6 LY96 TLR1 TLR10 TLR2
6
Show member pathways
12.83 IFNG IL10 IL6 IRAK3 LY96 TLR1
7
Show member pathways
12.76 IFNG IL18 IL6 TLR2 TLR4
8
Show member pathways
12.69 IL6 IRAK3 TLR1 TLR10 TLR2 TLR4
9
Show member pathways
12.65 IRAK3 LY96 TLR1 TLR10 TLR2 TLR4
10
Show member pathways
12.56 IFNG IL10 IL18 IL6 TLR2 TLR4
11 12.54 IFNG IL10 IRAK3 TLR1 TLR2
12
Show member pathways
12.53 IFNG IL10 IL18 IL6
13
Show member pathways
12.44 LY96 TLR1 TLR2 TLR4
14
Show member pathways
12.32 IFNG IL6 IRAK3 LY96 TLR4
15
Show member pathways
12.31 IFNG IL6 TLR2 TLR5
16
Show member pathways
12.3 IFNG IL10 LY96 TLR2 TLR4
17 12.23 IFNG IL10 IL18 IL6 TLR1 TLR2
18
Show member pathways
12.16 IFNG IL10 IL18 IL6
19 12.14 TLR1 TLR10 TLR2 TLR4 TLR5
20
Show member pathways
12.13 IFNG IL10 IL6
21 12.13 IFNG IL6 TLR1 TLR10 TLR2 TLR4
22
Show member pathways
12.1 TLR1 TLR10 TLR2 TLR4 TLR5
23
Show member pathways
12.04 IL6 IRAK3 LY96 TLR1 TLR10 TLR2
24 11.96 IFNG IL6 TLR4
25 11.96 IFNG IL10 IL6 TLR2 TLR4
26 11.95 IFNG IL10 IL6
27 11.94 IL10 IL18 IL6
28 11.92 IFNG IL18 IL6 TLR2 TLR4
29 11.88 IFNG IL18 IL6 TLR4 TLR5
30 11.87 IFNG IL6 TLR4
31 11.86 TLR1 TLR10 TLR2 TLR4 TLR5
32
Show member pathways
11.83 IL6 LY96 TLR4
33 11.82 IL10 IL6 LY96 TLR4
34
Show member pathways
11.81 IFNG IL6 TLR1 TLR10 TLR2 TLR4
35
Show member pathways
11.78 IFNG IL6 IRAK3 LY96 TLR1 TLR2
36 11.76 IFNG IL10 IL18
37 11.74 IFNG IL10 IL6
38 11.74 IL10 IL6 TLR2 TLR4 TLR5
39 11.68 IFNG IL10 IL6
40 11.6 IFNG IL18 TLR2 TLR4
41 11.6 IL18 IL6 TLR2 TLR4 TLR5
42 11.58 IRAK3 LY96 TLR4
43 11.53 IL10 IL18 IL6
44 11.49 IFNG IL10 IL18 IL6 TLR2 TLR4
45 11.44 IFNG IL10 IL18 IL6
46 11.38 IL10 IL6 TLR4
47 11.34 IFNG IL18 IL6
48 11.31 IFNG IL10 IL6
49
Show member pathways
11.31 IFNG IL10 IL18 IL6 TLR1 TLR10
50 11.26 IFNG IL18 TLR1 TLR2

GO Terms for Melioidosis

Cellular components related to Melioidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 HABP2 IFNG IL10 IL18 IL6 LY96
2 lipopolysaccharide receptor complex GO:0046696 9.16 LY96 TLR4
3 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.96 TLR1 TLR2
4 intrinsic component of plasma membrane GO:0031226 8.8 LY96 TLR2 TLR4

Biological processes related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.93 IFNG IL10 TLR1 TLR4 TLR5
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 IL6 IRAK3 TLR2 TLR4
3 response to lipopolysaccharide GO:0032496 9.88 IL10 IL6 IRAK3 LY96 TLR2 TLR4
4 immune response GO:0006955 9.86 IFNG IL10 IL18 IL6 TLR1 TLR10
5 response to insulin GO:0032868 9.85 IL10 IL6 TLR2
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 IFNG IL18 IL6
7 positive regulation of interleukin-6 production GO:0032755 9.81 IL6 TLR2 TLR4
8 positive regulation of inflammatory response GO:0050729 9.81 IL18 TLR10 TLR2 TLR4
9 cellular response to lipopolysaccharide GO:0071222 9.8 IFNG IL10 IL6 LY96 TLR4 TLR5
10 negative regulation of tumor necrosis factor production GO:0032720 9.79 IL10 IRAK3 TLR4
11 positive regulation of tumor necrosis factor production GO:0032760 9.78 IFNG LY96 TLR2 TLR4
12 positive regulation of interleukin-8 production GO:0032757 9.77 TLR2 TLR4 TLR5
13 negative regulation of interleukin-6 production GO:0032715 9.77 IL10 IRAK3 TLR4
14 toll-like receptor signaling pathway GO:0002224 9.77 LY96 TLR1 TLR10 TLR2 TLR4
15 positive regulation of interleukin-12 production GO:0032735 9.76 IFNG TLR2 TLR4
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 IFNG IL6 TLR4 TLR5
17 positive regulation of NF-kappaB import into nucleus GO:0042346 9.75 IL18 TLR2 TLR4
18 defense response to protozoan GO:0042832 9.74 IFNG IL10 IL6
19 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.73 LY96 TLR4
20 positive regulation of interferon-beta production GO:0032728 9.73 TLR2 TLR4
21 negative regulation of interferon-gamma production GO:0032689 9.73 IL10 TLR4
22 positive regulation of chemokine production GO:0032722 9.73 IL6 TLR2 TLR4
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 IL18 LY96 TLR2 TLR4
24 positive regulation of interleukin-10 production GO:0032733 9.72 TLR2 TLR4
25 necroptotic process GO:0070266 9.72 LY96 TLR4
26 toll-like receptor 4 signaling pathway GO:0034142 9.72 LY96 TLR4
27 negative regulation of growth of symbiont in host GO:0044130 9.72 IFNG IL10
28 cell activation GO:0001775 9.71 TLR1 TLR2
29 cellular response to hepatocyte growth factor stimulus GO:0035729 9.71 IL10 IL6
30 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 TLR2 TLR4
31 response to molecule of bacterial origin GO:0002237 9.71 IL10 TLR2
32 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.7 LY96 TLR4
33 I-kappaB phosphorylation GO:0007252 9.7 TLR2 TLR4
34 negative regulation of interleukin-12 production GO:0032695 9.7 IL10 IRAK3
35 positive regulation of protein import into nucleus, translocation GO:0033160 9.7 IFNG IL6
36 T-helper 1 type immune response GO:0042088 9.69 IL18 TLR4
37 negative regulation of interleukin-17 production GO:0032700 9.69 IFNG TLR4
38 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.69 TLR1 TLR4
39 macrophage activation GO:0042116 9.68 TLR1 TLR4
40 cellular response to lipoteichoic acid GO:0071223 9.68 TLR2 TLR4
41 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.68 IFNG TLR1
42 positive regulation of T-helper 2 cell differentiation GO:0045630 9.68 IL18 IL6
43 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.67 LY96 TLR4
44 positive regulation of MHC class II biosynthetic process GO:0045348 9.67 IFNG IL10 TLR4
45 response to peptidoglycan GO:0032494 9.66 IL6 IRAK3
46 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.66 IFNG TLR4
47 type 2 immune response GO:0042092 9.65 IL10 IL18
48 detection of lipopolysaccharide GO:0032497 9.65 LY96 TLR4
49 positive regulation of toll-like receptor signaling pathway GO:0034123 9.64 TLR2 TLR5
50 neutrophil apoptotic process GO:0001781 9.63 IFNG IL6

Molecular functions related to Melioidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 IFNG IL10 IL18 IL6
2 transmembrane signaling receptor activity GO:0004888 9.35 TLR1 TLR10 TLR2 TLR4 TLR5
3 lipopolysaccharide binding GO:0001530 9.32 TLR2 TLR4
4 lipopeptide binding GO:0071723 9.26 TLR1 TLR2
5 lipopolysaccharide receptor activity GO:0001875 8.8 LY96 TLR2 TLR4

Sources for Melioidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....