MCID: MLD001
MIFTS: 67

Melioidosis malady

Categories: Genetic diseases, Rare diseases, Infectious diseases, Immune diseases

Aliases & Classifications for Melioidosis

About this section
Sources:
2CDC, 11Disease Ontology, 13DISEASES, 27GTR, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Melioidosis:

Name: Melioidosis 52 11 48 54 27 50 2 39 13 68
Nightcliff Gardener's Disease 11 48
Whitmore's Disease 11 2
Melioidosis, Susceptibility to Melioidosis, Resistance to, Included 52
Burkholderia Pseudomallei Infection 48
Acute and Fulminating Melioidosis 11
 
Subacute and Chronic Melioidosis 11
Melioidosis, Unspecified 11
B Pseudomallei Infection 48
Epizootic Lymphangitis 68
Whitmore Disease 48
Pseudoglanders 11

Characteristics:

Orphanet epidemiological data:

54
melioidosis:
Age of onset: All ages

Classifications:



External Ids:

OMIM52 615557
Disease Ontology11 DOID:5052
ICD9CM32 025
MeSH39 D008554
Orphanet54 ORPHA31202
MESH via Orphanet40 D008554
ICD10 via Orphanet31 A24.1, A24.2, A24.3 A24.4, more
UMLS via Orphanet69 C0025229

Summaries for Melioidosis

About this section
NIH Rare Diseases:48 Melioidosis is an infectious disease caused by the bacteria Burkholderia pseudomallei that are commonly found in the soil and water. Melioidosis is a rare disease in the United States, but it is common in tropical or subtropical areas of the world, including Southeast Asia, Africa, and Australia. The signs and symptoms of the disease can vary greatly and may mimic those of tuberculosis or common forms of pneumonia. Signs and symptoms may include pain or swelling, fever, abscess, cough, high fever, headache, trouble breathing, and more. Although healthy people can also experience signs and symptoms of the disease, people with certain conditions like diabetes, liver disease, kidney disease, lung disease, thalassemia, cancer, or certain autoimmune diseases are more severely affected. Diagnosis is made by collecting blood, sputum, urine, or pus samples and growing the bacteria. Current treatment is divided into two stages: an intravenous (IV) antibiotic stage and oral antibiotic maintenance stage to prevent recurrence. Last updated: 1/13/2016

MalaCards based summary: Melioidosis, also known as nightcliff gardener's disease, is related to pasteurellosis and respiratory failure, and has symptoms including fever, respiratory distress and chest pain. An important gene associated with Melioidosis is TLR5 (Toll Like Receptor 5), and among its related pathways are IKK complex recruitment mediated by RIP1 and MIF Action Through Endocytic Pathway. Affiliated tissues include lung, liver and bone, and related mouse phenotypes are Decreased viability in esophageal squamous lineage and adipose tissue.

Disease Ontology:11 A primary bacterial infectious disease that results in infection, has material basis in Burkholderia pseudomallei, which is transmitted by contact with the contaminated water or soil. The infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.

OMIM:52 Melioidosis is infection caused by the gram-negative, flagellated soil saprophyte Burkholderia pseudomallei, which is... (615557) more...

CDC:2 Melioidosis, also called Whitmore's disease, is an infectious disease that can infect humans or animals. The disease is caused by the bacterium Burkholderia pseudomallei.

Wikipedia:71 Melioidosis is an infectious disease caused by a Gram-negative bacterium, Burkholderia pseudomallei,... more...

Related Diseases for Melioidosis

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Diseases related to Melioidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 242)
idRelated DiseaseScoreTop Affiliating Genes
1pasteurellosis29.9IFNG, IL6
2respiratory failure28.9IL10, IL6, TLR4
3systemic lupus erythematosus28.1IFNG, IL10, IL18, IL6, TLR5
4glanders10.7
5bulbospinal polio10.6IFNG, TLR4
6dentine erosion10.6IFNG, TLR4
7sinonasal undifferentiated carcinoma10.5TLR2, TLR4
8rickettsialpox10.5TLR2, TLR4
9atrial septal defect coronary sinus10.5TLR2, TLR4
10steatorrhea10.5IFNG, IL18
11panner disease10.5IFNG, IL6
12trichosporonosis10.4TLR1, TLR2
13lymphocytic colitis10.4IFNG, IL6
14opiate dependence10.4IFNG, IL6
15midline interhemispheric variant of holoprosencephaly10.4IL18, IL6
16subglottis neoplasm10.4IL6, TLR4
17mycobacterium fortuitum10.4TLR1, TLR2
18tinea barbae10.4IFNG, TLR1, TLR4
19splenic manifestation of prolymphocytic leukemia10.4IL6, TLR2
20gallbladder lymphoma10.4TLR2, TLR4, TLR5
21labia minora cancer10.3IL6, TLR2
22toxocariasis10.3IFNG, TLR2, TLR4
23nasopharyngitis10.3TLR2, TLR4, TLR5
24queensland tick typhus10.3IL6, TLR2
25arteriolosclerosis10.3IL18, IL6
26qualitative platelet defect10.3IL18, IL6
27neurofibroma of the esophagus10.3IL18, IL6
28sterility due to immotile flagella10.3IL18, IL6
29syphilitic encephalitis10.3IL18, IL6
30atrial tachyarrhythmia with short pr interval10.2IFNG, TLR2
31renal cell carcinoma 410.2IFNG, IL18, IL6
32antigen-peptide-transporter 2 deficiency10.2IL6, TLR2, TLR4
33eye accommodation disease10.2IFNG, IL10
34nervous system disease10.2IFNG, IL6, TLR2
35parametrium malignant neoplasm10.2IL6, TLR1, TLR2
36thelaziasis10.1IFNG, IL10
37graft-versus-host disease, protection against10.1IFNG, IL10
38addison's disease10.1IFNG, IL10
39chronic hiccups10.1IFNG, IL10
40anterior foramen magnum meningioma10.1IFNG, TLR4
41buruli ulcer10.1IFNG, IL10
42hereditary hemorrhagic telangiectasia10.1IL6, TLR2, TLR4
43nelson syndrome10.1IFNG, IL10
44compensatory emphysema10.1IFNG, TLR1, TLR2, TLR4
45primary orthostatic tremor10.1IFNG, IL10
46hernia of ovary and fallopian tube10.1IFNG, IL10
47orbit alveolar rhabdomyosarcoma10.1IFNG, IL10
48cutaneous porphyria10.1IFNG, IL6, TLR4, TLR5
49lipodermatosclerosis10.1IFNG, IL10
50predominantly cortical thymoma10.0IL10, IL6

Graphical network of the top 20 diseases related to Melioidosis:



Diseases related to melioidosis

Symptoms & Phenotypes for Melioidosis

About this section


Clinical features from OMIM:

615557

Symptoms:

 11 (show all 4)
  • fever
  • respiratory distress
  • chest pain
  • stomach pain

GenomeRNAi Phenotypes related to Melioidosis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00235-A8.1HABP2, IL18, IL6, IRAK3, LY96, TLR1

MGI Mouse Phenotypes related to Melioidosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.7IL18, IL6, TLR2, TLR4, TLR5
2MP:00020069.0IFNG, IL10, IL6, TLR2, TLR4
3MP:00107718.7IFNG, IL10, IL18, IL6, TLR2, TLR4
4MP:00053698.6IFNG, IL10, IL18, IL6, TLR2, TLR4
5MP:00053858.5IFNG, IL10, IL18, IL6, TLR2, TLR4
6MP:00053818.5IFNG, IL10, IL18, IL6, TLR2, TLR4
7MP:00053708.2HABP2, IFNG, IL10, IL6, TLR2, TLR4
8MP:00053888.0IFNG, IL10, IL6, TLR2, TLR4, TLR5
9MP:00053977.1IFNG, IL10, IL18, IL6, IRAK3, LY96
10MP:00053876.6HABP2, IFNG, IL10, IL18, IL6, IRAK3

Drugs & Therapeutics for Melioidosis

About this section

Drugs for Melioidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ceftazidimeapproved6278439-06-25481173
Synonyms:
(6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl}amino)-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(1-hydroxy-2-methyl-1-oxopropan-2-yl)oxyiminoacetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(1-hydroxy-2-methyl-1-oxopropan-2-yl)oxyiminoacetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-(1-hydroxy-2-methyl-1-oxopropan-2-yl)oxyiminoacetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
7-[[2-(2-amino-1,3-thiazol-4-yl)-2-(1-hydroxy-2-methyl-1-oxopropan-2-yl)oxyiminoacetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
72558-82-8
7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-(pyridinium-1-ylmethyl)-3,4-didehydrocepham-4-carboxylate
AB00513848
AC1L1E5K
AC1L3MNA
AC1NUK7U
AC1NUN9Q
BIDD:GT0734
BRN 4344904
C06889
C2225
C22H22N6O7S2
CAZ
CEFTAZIDIME (ARGININE FORMULATION)
CHEBI:3508
CHEMBL201
CID2650
CID5481173
CID5484131
 
Ceftazidim
Ceftazidima
Ceftazidima [INN-Spanish]
Ceftazidime
Ceftazidime (INN)
Ceftazidime (TN)
Ceftazidime Sodium In Plastic Container
Ceftazidime anhydrous
Ceftazidime pentahydrate
Ceftazidimum
Ceftazidimum [INN-Latin]
Ceptaz
Ceptaz (TN)
D07654
DB00438
EINECS 276-715-9
Fortaz
Fortaz (TN)
Fortaz In Plastic Container
HMS2090M13
I06-1102
LS-132194
SN 401
UNII-9M416Z9QNR
ceftazidima
ceftazidime
ceftazidimum
2
Meropenemapproved, investigational88119478-56-764778, 441130
Synonyms:
(1R,5S,6S)-2-[(3S,5S)-5-(dimethylaminocarbonyl)pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid trihydrate
(1R,5S,6S)-2-[(3S,5S)-5-DIMETHYLAMINOCARBONYLPYRROLIDIN-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid
(2S,3R,4R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-{[(3S,5R)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid
(4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
(4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
(5S,6S)-3-((3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-ylthio)-6-((S)-1-hydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid
(6S)-2-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-1beta-methyl-2,3-didehydro-1-carbapenam-3-carboxylic acid
96036-03-2
AB00514051
AB1004614
AC1L9ALL
Ambap119478-56-7
Antibiotic SM 7338
Antibiotic sm 7338
BIDD:GT0851
BPBio1_001334
BSPBio_001212
CHEBI:43968
CHEMBL127
CID441130
CPD000469184
D08185
HMS1571M14
HMS2051G08
HMS2090C05
 
ICI-194660
MEPM
MERONEM
MLS001401437
Meronem (TN)
Meropen
Meropenem
Meropenem (INN)
Meropenem Hydrate
Meropenem anhydrous
Meropenem trihydrate
Meropenemum
Meropenemum [INN-Latin]
Meropenemum trihydricum
Merrem
Merrem I.V. (TN)
MolPort-006-709-417
NCGC00179259-01
Prestwick0_001106
Prestwick1_001106
Prestwick2_001106
Prestwick3_001106
SAM001246650
SM-7338
SMR000469184
SPBio_003086
3
Trimethoprimapproved, vet_approved173738-70-55578
Synonyms:
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
46984_FLUKA
46984_RIEDEL
5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine
738-70-5
92131_FLUKA
92131_SIGMA
AB00052118
AB1004879
AC-13572
AC1L1KNQ
AC1Q48DF
AI3-52594
AKOS001650069
ARONIS24118
AZT + TMP/SMX (mixture) combination
Abacin
Abaprim
Alcorim-F
Alprim
Anitrim
Antrima
Antrimox
Apo-Sulfatrim
BB_SC-2116
BIDD:GT0190
BPBio1_000215
BRD-K07208025-001-06-5
BRN 0625127
BSPBio_000195
BSPBio_002245
BW 56-72
BW 5672
BW-56-72
Bacdan
Bacidal
Bacide
Bacin
Bacta
Bacterial
Bacterial [Antibiotic]
Bacticel
Bactin
Bactoprim
Bactramin
Bactrim
Bactrim DS
Bactrim Pediatric
Baktar
Bencole
Bethaprim
Biosulten
Briscotrim
C01965
CAS-738-70-5
CCRIS 2410
CHEBI:45924
CHEMBL22
CID5578
CPD0-1581
CPD000035999
Chemotrim
Chemotrin
Cidal
Co-Trimoxizole
Co-trimoxazole
Colizole
Colizole DS
Comox
Conprim
Cotrim
Cotrim D.S.
Cotrimel
D00145
D014295
DB00440
Deprim
DivK1c_000589
Drylin
Duocide
EINECS 212-006-2
EU-0101271
Esbesul
Espectrin
Euctrim
Eusaprim
Exbesul
Fectrim
Fermagex
Fortrim
Futin
Gantaprim
Gantrim
HMS1568J17
HMS1921I03
HMS2090D14
HMS2092A10
HMS501N11
HSDB 6781
I06-0086
IDI1_000589
Idotrim
Ikaprim
Imexim
Instalac
Ipral
KBio1_000589
KBio2_000647
KBio2_003215
KBio2_005783
KBio3_001465
KBioGR_000863
KBioSS_000647
KSC-4-158
KUC103659N
Kepinol
Kombinax
LS-1627
Lagatrim
Lagatrim Forte
Laratrim
Lastrim
Lidaprim
Linaris
Lopac-T-7883
Lopac0_001271
MLS000079023
MLS001201740
MLS002303068
Methoprim
Metoprim
Microtrim
MolPort-001-826-685
Monoprim
Monotrim
Monotrimin
NCGC00016055-01
NCGC00016055-02
NCGC00016055-06
NCGC00016055-12
NCGC00024707-01
NCGC00024707-03
NCGC00024707-04
NCGC00024707-05
NCGC00024707-06
NCGC00024707-07
NCGC00024707-08
NIH 204
 
NIH 204 (VAN)
NINDS_000589
NSC 106568
NSC-106568
NSC106568
Nopil
Novotrimel
Omstat
Oprea1_495058
Oraprim
Pancidim
Polytrim
Prestwick0_000208
Prestwick1_000208
Prestwick2_000208
Prestwick3_000208
Prestwick_485
Priloprim
Primosept
Primsol
Proloprim
Proloprim (TN)
Protrin
Purbal
Resprim
Resprim Forte
Roubac
Roubal
SAM002264649
SMP2_000262
SMR000035999
SPBio_000874
SPBio_002116
SPECTRUM1500595
STK177322
Salvatrim
Septra
Septra DS
Septra Grape
Septrin
Septrin DS
Septrin Forte
Septrin S
Setprin
Sigaprim
Sinotrim
Smz-Tmp
Spectrum2_000937
Spectrum3_000643
Spectrum4_000372
Spectrum5_001559
Spectrum_000167
Stopan
Streptoplus
Sugaprim
Sulfamar
Sulfamethoprim
Sulfamethoprim-DS
Sulfamethoxazole & Trimethoprim
Sulfatrim
Sulfatrim Pediatric
Sulfatrim-DS
Sulfatrim-SS
Sulfotrim
Sulfoxaprim
Sulmeprim
Sulmeprim Pediatric
Sulprim
Sulthrim
Sultrex
Sumetrolim
Supracombin
Suprim
Syraprim
T 7883
T2286
T7883_SIGMA
TCMDC-125538
TL8005108
TMP/SMX (MIXTURE))
Teleprim
Thiocuran
Tiempe
Tmp-Ratiopharm
Tocris-0650
Toprim
Trigonyl
Trimanyl
Trimesulf
Trimeth/Sulfa
Trimethioprim
Trimethopim(TMP)
Trimethoprim
Trimethoprim & VRC3375
Trimethoprim (JAN/USP/INN)
Trimethoprim [USAN:BAN:INN:JAN]
Trimethoprime
Trimethoprime [INN-French]
Trimethoprimum
Trimethoprimum [INN-Latin]
Trimethopriom
Trimetoprim
Trimetoprim [DCIT]
Trimetoprim [Polish]
Trimetoprima
Trimetoprima [INN-Spanish]
Trimexazole
Trimexol
Trimez-IFSA
Trimezol
Trimogal
Trimono
Trimopan
Trimpex
Trimpex (TN)
Trimpex 200
Triméthoprime
Triprim
Trisul
Trisulcom
Trisulfam
Trisural
U-Prin
UNII-AN164J8Y0X
UPCMLD-DP132
UPCMLD-DP132:001
Unitrim
Uretrim
Uro-D S
Uro-Septra
Urobactrim
Uroplus
Uroplus DS
Uroplus SS
Utetrin
Velaten
WLN: T6N CNJ BZ DZ E1R CO1 DO1 EO1
WR 5949
Wellcoprim
Wellcoprin
Xeroprim
ZINC06627681
Zamboprim
component of Bactrim
component of Septra
nchembio.108-comp1
nchembio.215-comp11
nchembio.221-comp23
trimethoprim
4
Sulfamethoxazoleapproved158723-46-65329
Synonyms:
129378-89-8
3-(Para-Aminophenylsulphonamido)-5-methylisoxazole
3-(p-Aminobenzenesulfonamido)-5-methylisoxazole
3-(p-Aminophenylsulfonamido)-5-methylisoxazole
3-(para-Aminophenylsulphonamido)-5-methylisoxazole
3-Sulfanilamido-5-methylisoxazole
3-Sulphanilamido-5-methylisoxazole
4-Amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
4-Amino-N-(5-methyl-3-isoxazolyl)-Benzenesulfonamide
4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
4-Amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide
4-Amino-N-[5-methyl-3- isoxazolyl]benzenesulfonamide
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide
46850_RIEDEL
5-Methyl-3-sulfanilamidoisoxazole
5-Methyl-3-sulfanylamidoisoxazole
5-Methyl-3-sulfonylamidoisoxazole
5-Methyl-3-sulphanil-amidoisoxazole
723-46-6
A047
AB00052099
AC-11118
AC1L1K42
AC1Q2J5R
AKOS000200952
ALBB-002089
ARONIS018156
Apo-Sulfamethoxazole
Azo Gantanol
Azo-Gantanol
Azo-gantanol
BAS 00836086
BB_SC-1251
BIDD:GT0731
BPBio1_000081
BRD-K28494619-001-05-0
BRN 0226453
BSPBio_000073
BSPBio_002028
Bactrim
Bactrimel
C07315
C10H11N3O3S
CAS-723-46-6
CCRIS 567
CHEBI:9332
CHEMBL443
CID5329
CPD000058223
D00447
D013420
DB01015
DivK1c_000649
EINECS 211-963-3
Gamazole
Gantanol
Gantanol (TN)
Gantanol (tn)
Gantanol-DS
HMS1568D15
HMS1921A21
HMS2092K03
HMS502A11
HMS561O18
HSDB 3186
I01-0154
IDI1_000649
InChI=1/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)
KBio1_000649
KBio2_001474
KBio2_004042
KBio2_006610
KBio3_001528
KBioGR_000749
KBioSS_001474
LS-1620
MLS000069732
MLS001055354
MLS001074165
MS 53
Maybridge1_007190
Metoxal
MolPort-000-145-787
N'-(5-Methyl-3-isoxazole)sulfanilamide
 
N'-(5-Methyl-3-isoxazolyl)-Sulfanilamide
N'-(5-Methyl-3-isoxazolyl)sulfanilamide
N'-(5-Methylisoxazol-3-yl)sulphanilamide
N(Sup1)-(5-Methyl-3-isoxazolyl)sulfanilamide
N(sup 1)-(5-Methyl-3-isoxazolyl)sulfanilamide
N(sup 1)-(5-Methyl-3-isoxazolyl)sulphanilamide
N(sup1)-(5-Methyl-3-isoxazolyl)sulfanilamide
N1-(5-Methyl-3-isoxazolyl)sulfanilamide
N1-(5-Methyl-3-isoxazolyl)sulphanilamide
N1-(5-Methylisoxazol-3-yl)sulfanilamide
N1-(5-methyl-3-isoxazolyl)-Sulfanilamide
NCGC00016533-01
NCGC00016533-02
NCGC00021995-03
NCGC00021995-04
NCGC00021995-05
NINDS_000649
NSC 147832
NSC147832
N^1-(5-Methyl-3-isoxazolyl)-Sulfanilamide
Ndimethyl1-(5-methyl-3-isoxazolyl)-Sulfanilamide
Oprea1_114486
Oprea1_285680
Prestwick0_000177
Prestwick1_000177
Prestwick2_000177
Prestwick3_000177
Prestwick_453
Radonil
Ro 4-2130
Ro 6-2580/11
Ro-4-2130
S0361
S1915_Selleck
S7507_FLUKA
S7507_SIGMA
SAM002554930
SIM
SMR000058223
SMX
SPBio_000896
SPBio_001994
SPECTRUM1500550
STK007988
SULFAMETHOXAZOLE (8064-90-2 (TRIMETHOPRIM/SULFAMETHOXAZOLE)
Septran
Simsinomin
Sinomin
Solfametossazolo
Solfametossazolo [DCIT]
Spectrum2_000788
Spectrum3_000584
Spectrum4_000345
Spectrum5_000982
Spectrum_000994
Sulfamethalazole
Sulfamethoxazol
Sulfamethoxazole
Sulfamethoxazole (JP15/USP/INN)
Sulfamethoxazole [USAN:INN:JAN]
Sulfamethoxazole sodium
Sulfamethoxazole(USAN)
Sulfamethoxazolum
Sulfamethoxazolum [INN-Latin]
Sulfamethoxizole
Sulfamethylisoxazole
Sulfametoxazol
Sulfametoxazol [INN-Spanish]
Sulfanilamide, N1-(5-methyl-3-isoxazolyl)- (8CI)
Sulfisomezole
Sulpha-Methoxizole
Sulpha-methoxizole
Sulphamethalazole
Sulphamethoxazol
Sulphamethoxazole
Sulphamethoxazole BP 98
Sulphamethylisoxazole
Sulphisomezole
TL8005058
TMP/SMX (MIXTURE))
Trib
UNII-JE42381TNV
Urobak
WLN: T5NOJ C1 EMSWR DZ
ZINC00089763
nchembio.221-comp24
sulfamethoxazole
5Anti-Bacterial Agents10884
6Pharmaceutical Solutions7793
7Anti-Infective Agents21402
8Thienamycins53
9Immunoglobulins6045
10Antibodies6045
11Trimethoprim, Sulfamethoxazole Drug Combination164
12Antimalarials1216
13Renal Agents732
14Antiprotozoal Agents1986
15Antiparasitic Agents2127

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe MelioidosisUnknown statusNCT00579956
2Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)CompletedNCT01766830
3A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast ThailandRecruitingNCT02089152
4Study to Obtain Blood and Voided Urine Samples to Improve the Diagnosis of MelioidosisRecruitingNCT02668406
5Co-trimoxazole as Maintenance Therapy for MeliodosisRecruitingNCT01420341

Search NIH Clinical Center for Melioidosis


Cochrane evidence based reviews: melioidosis

Genetic Tests for Melioidosis

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Genetic tests related to Melioidosis:

id Genetic test Affiliating Genes
1 Melioidosis, Susceptibility to27

Anatomical Context for Melioidosis

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MalaCards organs/tissues related to Melioidosis:

36
Lung, Liver, Bone, Skin, Kidney, Testes, T cells

Publications for Melioidosis

About this section

Articles related to Melioidosis:

(show top 50)    (show all 629)
idTitleAuthorsYear
1
Anion inhibition profiles of the I^-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei responsible of melioidosis and highly drug resistant to common antibiotics. (27914949)
2017
2
Imported Case of Melioidosis in Oman: Case Report. (28042405)
2017
3
A case-control study of community-acquired Acinetobacter baumannii pneumonia and melioidosis pneumonia in northeast Thailand: an emerging fatal disease with unique clinical features. (27789057)
2017
4
Sulfonamide inhibition profile of the I^-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis. (28025002)
2017
5
Melioidosis in Travelers Returning from Vietnam to France. (27532771)
2016
6
Chronic melioidosis presenting with multiple abscesses. (27822380)
2016
7
Formulation and Characterization of Nanocluster Ceftazidime for the Treatment of Acute Pulmonary Melioidosis. (27639659)
2016
8
An 11-Year Analysis of Emergency Presentations of Melioidosis in Northeastern Malaysia. (27160769)
2016
9
Cutaneous Melioidosis Cluster Caused by Contaminated Wound Irrigation Fluid. (27438887)
2016
10
Phylogenomic Analysis Reveals an Asian Origin for African Burkholderia pseudomallei and Further Supports Melioidosis Endemicity in Africa. (27303718)
2016
11
Melioidosis: A Rare Cause of Liver Abscess. (27529039)
2016
12
Melioidosis in Malaysia: A Review of Case Reports. (28005910)
2016
13
Characteristics, clinical outcomes and factors influencing mortality of patients with melioidosis in southern Thailand: A 10-year retrospective study. (26972397)
2016
14
The epidemiology and clinical spectrum of melioidosis in a teaching hospital in a North-Eastern state of Malaysia: a fifteen-year review. (27423906)
2016
15
Goodpasture disease as a consequence of melioidosis. (27981771)
2016
16
Cutaneous Melioidosis. (27790560)
2016
17
Therapeutic Administration of a Monoclonal Anti-Il-1I^ Antibody Protects Against Experimental Melioidosis. (27219859)
2016
18
Efficacy of indirect ELISA for serodiagnosis of melioidosis using immunodominant antigens from non-pathogenic Burkholderia thailandensis. (27812452)
2016
19
Melioidosis: a greater threat than previously suspected? (27436814)
2016
20
The melioidosis agent Burkholderia pseudomallei and related opportunistic pathogens detected in faecal matter of wildlife and livestock in northern Australia. (26935879)
2016
21
Rapid and Sensitive Multiplex Detection of Burkholderia pseudomallei-Specific Antibodies in Melioidosis Patients Based on a Protein Microarray Approach. (27427979)
2016
22
Melioidosis: where do we stand in the development of an effective vaccine? (27081770)
2016
23
Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Impairs Host Defense in Experimental Melioidosis. (27253382)
2016
24
Endocarditis in melioidosis (28078837)
2016
25
Neonatal Melioidosis with Pneumatoceles. (27156557)
2016
26
A rare case of melioidosis presenting as isolated liver abscess. (27728711)
2016
27
Melioidosis and glanders modulation of the innate immune system: barriers to current and future vaccine approaches. (27010618)
2016
28
Protection against Experimental Melioidosis with a Synthetic manno-Heptopyranose Hexasaccharide Glycoconjugate. (27124182)
2016
29
Identification of an OmpW homologue in Burkholderia pseudomallei, a protective vaccine antigen against melioidosis. (27091689)
2016
30
Involvement of L-selectin expression in Burkholderia pseudomallei-infected monocytes invading the brain during murine melioidosis. (27646437)
2016
31
Increasing Experience With Melioidosis and Critical Care: Medical and Military Implications. (27428122)
2016
32
Acute pulmonary melioidosis presenting with multiple bilateral cavitary lesions in a healthy young adult: an authentic case report from Sri Lanka. (27448660)
2016
33
Melioidosis Causing Critical Illness: A Review of 24 Years of Experience From the Royal Darwin Hospital ICU. (26963328)
2016
34
Subcutaneous abscess formation in septic melioidosis, devoid of associated risk factors. (27051580)
2016
35
The association of melioidosis with climatic factors in Darwin, Australia: A 23-year time-series analysis. (26945846)
2016
36
Melioidosis parotitis in children. (27980534)
2016
37
Musculoskeletal melioidosis: An under-diagnosed entity in developing countries. (26955222)
2016
38
Emerging trends in melioidosis - A case series. (27728451)
2016
39
Burkholderia pseudomallei: First case of melioidosis in Portugal. (26962474)
2016
40
Burkholderia pseudomallei capsule exacerbates respiratory melioidosis but does not afford protection against antimicrobial signalling or bacterial killing in human olfactory ensheathing cells. (27091931)
2016
41
Pitfalls and optimal approaches to diagnose melioidosis. (27262061)
2016
42
Guillaine-barre syndrome; a rare complication of melioidosis. a case report. (27506202)
2016
43
Fatal Melioidosis Infection in a Newborn from Hainan, China. (27162267)
2016
44
PERITONEAL DIALYSIS-RELATED PERITONITIS DUE TO MELIOIDOSIS: A POTENTIALLY DEVASTATING CONDITION. (27738086)
2016
45
Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. (27571754)
2016
46
Identification of CD4+ T-cell epitope and investigation of HLA distribution for the immunogenic proteins of Burkholderia pseudomallei using in silico approaches - A key vaccine development strategy for melioidosis. (27086038)
2016
47
Melioidosis in a patient with chronic rhinosinusitis. (27488340)
2016
48
Eighth World Melioidosis Congress, 2016: presenting an emerging infectious disease in the context of a89One Healtha89. (27855480)
2016
49
The antibiotics of choice for the treatment of melioidosis in Indian set up. (27514960)
2016
50
Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis. (26927094)
2016

Variations for Melioidosis

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Expression for genes affiliated with Melioidosis

About this section
LifeMap Discovery
Genes differentially expressed in tissues of Melioidosis patients vs. healthy controls: 35 (show all 181)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CD177CD177 moleculeBlood+8.410.000
2ZDHHC19zinc finger, DHHC-type containing 19Blood+6.910.000
3MMP8matrix metallopeptidase 8Blood+6.490.000
4SLC51Asolute carrier family 51, alpha subunitBlood+6.460.000
5HPhaptoglobinBlood+6.230.000
6FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptideBlood-6.000.000
7GPR84G protein-coupled receptor 84Blood+5.860.000
8ANKRD22ankyrin repeat domain 22Blood+5.720.000
9OLAHoleoyl-ACP hydrolaseBlood+5.540.000
10LRRN3leucine rich repeat neuronal 3Blood-5.510.000
11PCOLCE2procollagen C-endopeptidase enhancer 2Blood+5.470.000
12C1QCcomplement component 1, q subcomponent, C chainBlood+5.420.000
13PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2Blood+5.390.000
14CCNA1cyclin A1Blood+5.140.000
15C1QBcomplement component 1, q subcomponent, B chainBlood+5.090.000
16LINC00668long intergenic non-protein coding RNA 668Blood+4.990.000
17CACNA1Ecalcium channel, voltage-dependent, R type, alpha 1E subunitBlood+4.980.000
18FGF13fibroblast growth factor 13Blood+4.960.000
19NOVnephroblastoma overexpressedBlood-4.840.000
20PLVAPplasmalemma vesicle associated proteinBlood-4.760.000
21KLklothoBlood+4.740.000
22SLCO4A1solute carrier organic anion transporter family, member 4A1Blood+4.730.000
23MYO10myosin XBlood+4.680.000
24SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3Blood+4.680.000
25RPGRIP1retinitis pigmentosa GTPase regulator interacting protein 1Blood-4.670.000
26RETNresistinBlood+4.650.000
27CD274CD274 moleculeBlood+4.440.000
28MCEMP1mast cell-expressed membrane protein 1Blood+4.440.000
29BMXBMX non-receptor tyrosine kinaseBlood+4.410.000
30SERPINA1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1Blood+4.380.000
31CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)Blood+4.380.000
32GRB10growth factor receptor-bound protein 10Blood+4.370.000
33CACNA2D3calcium channel, voltage-dependent, alpha 2/delta subunit 3Blood-4.250.000
34LINC01220long intergenic non-protein coding RNA 1220Blood+4.200.000
35LTFlactotransferrinBlood+4.190.000
36SLC26A8solute carrier family 26 (anion exchanger), member 8Blood+4.180.000
37ARG1arginase 1Blood+4.170.000
38IL18R1interleukin 18 receptor 1Blood+4.170.000
39IL1R2interleukin 1 receptor, type IIBlood+4.080.000
40SLC2A11solute carrier family 2 (facilitated glucose transporter), member 11Blood+4.060.000
41CFHcomplement factor HBlood+4.030.000
42G0S2G0/G1 switch 2Blood+4.020.000
43MMP9matrix metallopeptidase 9Blood+3.970.000
44FCARFc fragment of IgA receptorBlood+3.940.000
45SCN9Asodium channel, voltage gated, type IX alpha subunitBlood+3.940.000
46FAM20Afamily with sequence similarity 20, member ABlood+3.940.000
47KRTAP19-6keratin associated protein 19-6Blood+3.930.000
48TDRD9tudor domain containing 9Blood+3.920.000
49KREMEN1kringle containing transmembrane protein 1Blood+3.860.000
50HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7Blood+3.840.000
51CR1complement component (3b/4b) receptor 1 (Knops blood group)Blood+3.830.000
52VNN1vanin 1Blood+3.820.000
53LGALSLlectin, galactoside-binding-likeBlood-3.810.000
54COL17A1collagen, type XVII, alpha 1Blood+3.810.000
55NELL2neural EGFL like 2Blood-3.790.000
56SLAMF8SLAM family member 8Blood+3.790.000
57ELOVL4ELOVL fatty acid elongase 4Blood-3.760.000
58BATF2basic leucine zipper transcription factor, ATF-like 2Blood+3.760.000
59C1QAcomplement component 1, q subcomponent, A chainBlood+3.750.000
60ANKRD34Bankyrin repeat domain 34BBlood+3.740.000
61NTSR1neurotensin receptor 1 (high affinity)Blood+3.740.000
62NAIPNLR family, apoptosis inhibitory proteinBlood+3.740.000
63TNFAIP8L3tumor necrosis factor, alpha-induced protein 8-like 3Blood+3.720.000
64LOC55338uncharacterized LOC55338Blood+3.720.000
65KIAA1671KIAA1671Blood-3.680.000
66PTGDR2prostaglandin D2 receptor 2Blood-3.680.000
67BCL6B-cell CLL/lymphoma 6Blood+3.660.000
68IL5RAinterleukin 5 receptor, alphaBlood-3.660.000
69METTL7Bmethyltransferase like 7BBlood+3.650.000
70PTGDRprostaglandin D2 receptor (DP)Blood-3.630.000
71CD160CD160 moleculeBlood-3.620.000
72GALNT14polypeptide N-acetylgalactosaminyltransferase 14Blood+3.600.000
73AP3B2adaptor-related protein complex 3, beta 2 subunitBlood+3.580.000
74GCATglycine C-acetyltransferaseBlood-3.580.000
75ANXA3annexin A3Blood+3.560.000
76DAAM2dishevelled associated activator of morphogenesis 2Blood+3.550.000
77CLEC4CC-type lectin domain family 4, member CBlood-3.550.000
78CD248CD248 molecule, endosialinBlood-3.550.000
79SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 1Blood+3.540.000
80TCN2transcobalamin IIBlood+3.540.000
81PLEKHG4pleckstrin homology domain containing, family G (with RhoGef domain) member 4Blood-3.530.000
82GBP6guanylate binding protein family, member 6Blood+3.530.000
83HDChistidine decarboxylaseBlood-3.520.000
84TCTEX1D1Tctex1 domain containing 1Blood+3.520.000
85LINC00937long intergenic non-protein coding RNA 937Blood+3.510.000
86PID1phosphotyrosine interaction domain containing 1Blood-3.500.000
87PIM3Pim-3 proto-oncogene, serine/threonine kinaseBlood+3.490.000
88CD3DCD3d molecule, delta (CD3-TCR complex)Blood-3.480.000
89CARD17caspase recruitment domain family, member 17Blood+3.470.000
90MAP2K6mitogen-activated protein kinase kinase 6Blood+3.450.000
91SUPT3HSPT3 homolog, SAGA and STAGA complex componentBlood-3.430.000
92BPIbactericidal/permeability-increasing proteinBlood+3.420.000
93LIPMlipase, family member MBlood+3.420.000
94LGALS2lectin, galactoside-binding, soluble, 2Blood-3.420.000
95KLHL3kelch-like family member 3Blood-3.400.000
96UGCGUDP-glucose ceramide glucosyltransferaseBlood+3.400.000
97SPINK2serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)Blood-3.400.000
98OLIG2oligodendrocyte lineage transcription factor 2Blood-3.390.000
99KCNJ15potassium channel, inwardly rectifying subfamily J, member 15Blood+3.390.000
100DBPD site of albumin promoter (albumin D-box) binding proteinBlood-3.380.000
101PRSS23protease, serine, 23Blood-3.380.000
102MUC1mucin 1, cell surface associatedBlood+3.370.000
103NT5E5'-nucleotidase, ecto (CD73)Blood-3.360.000
104TROtrophininBlood+3.350.000
105UG0898H09uncharacterized LOC643763Blood+3.350.000
106ZNF69zinc finger protein 69Blood-3.350.000
107AIM2absent in melanoma 2Blood+3.340.000
108PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3Blood+3.310.000
109DNASE1L3deoxyribonuclease I-like 3Blood-3.310.000
110FHITfragile histidine triadBlood-3.310.000
111MT1Gmetallothionein 1GBlood+3.300.000
112STOMstomatinBlood+3.300.000
113CFBcomplement factor BBlood+3.300.000
114MIR205HGMIR205 host geneBlood+3.300.000
115KIF20Akinesin family member 20ABlood+3.290.000
116LINC00342long intergenic non-protein coding RNA 342Blood+3.290.000
117GSTM1glutathione S-transferase mu 1Blood-3.290.000
118NECAB1N-terminal EF-hand calcium binding protein 1Blood+3.270.000
119HGFhepatocyte growth factor (hepapoietin A; scatter factor)Blood+3.260.000
120CEACAM8carcinoembryonic antigen-related cell adhesion molecule 8Blood+3.260.000
121TMOD3tropomodulin 3 (ubiquitous)Blood+3.240.000
122SIGLEC17Psialic acid binding Ig-like lectin 17, pseudogeneBlood-3.240.000
123APOL1apolipoprotein L, 1Blood+3.240.000
124HLA-DQB1major histocompatibility complex, class II, DQ beta 1Blood-3.240.000
125MS4A4Amembrane-spanning 4-domains, subfamily A, member 4ABlood+3.230.000
126OLFM1olfactomedin 1Blood-3.230.000
127ENTPD7ectonucleoside triphosphate diphosphohydrolase 7Blood+3.220.000
128GPR141G protein-coupled receptor 141Blood+3.220.000
129ZAKsterile alpha motif and leucine zipper containing kinase AZKBlood+3.220.000
130EDARectodysplasin A receptorBlood-3.210.000
131IL27interleukin 27Blood+3.210.000
132OPLAH5-oxoprolinase (ATP-hydrolysing)Blood+3.210.000
133OLFM4olfactomedin 4Blood+3.200.000
134TNFAIP6tumor necrosis factor, alpha-induced protein 6Blood+3.200.000
135TIFATRAF-interacting protein with forkhead-associated domainBlood+3.190.000
136IRAK3interleukin-1 receptor-associated kinase 3Blood+3.190.000
137DTX3deltex 3, E3 ubiquitin ligaseBlood-3.190.000
138VSIG4V-set and immunoglobulin domain containing 4Blood+3.190.000
139PDCD1LG2programmed cell death 1 ligand 2Blood+3.190.000
140LILRA5leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5Blood+3.190.000
141S100A12S100 calcium binding protein A12Blood+3.190.000
142SOCS3suppressor of cytokine signaling 3Blood+3.180.000
143VIPR1vasoactive intestinal peptide receptor 1Blood-3.170.000
144EBI3Epstein-Barr virus induced 3Blood+3.170.000
145ENKURenkurin, TRPC channel interacting proteinBlood-3.150.000
146LIMK2LIM domain kinase 2Blood+3.150.000
147CCDC65coiled-coil domain containing 65Blood-3.150.000
148FBLN2fibulin 2Blood-3.150.000
149LRRN1leucine rich repeat neuronal 1Blood+3.150.000
150APOL6apolipoprotein L, 6Blood+3.140.000
151ACVR1Bactivin A receptor, type IBBlood+3.140.000
152CPA3carboxypeptidase A3 (mast cell)Blood-3.140.000
153KLF5Kruppel-like factor 5 (intestinal)Blood+3.140.000
154CD1CCD1c moleculeBlood-3.120.000
155OTOFotoferlinBlood+3.120.000
156CD8BCD8b moleculeBlood-3.120.000
157LINC01138long intergenic non-protein coding RNA 1138Blood+3.110.000
158LYRM4LYR motif containing 4Blood-3.100.000
159KIF1Bkinesin family member 1BBlood+3.100.000
160EPHA4EPH receptor A4Blood-3.090.000
161SLC2A14solute carrier family 2 (facilitated glucose transporter), member 14Blood+3.090.000
162CCR3chemokine (C-C motif) receptor 3Blood-3.090.000
163SFTPDsurfactant protein DBlood-3.090.000
164HIST2H2ABhistone cluster 2, H2abBlood+3.080.000
165RALGAPA2Ral GTPase activating protein, alpha subunit 2 (catalytic)Blood+3.080.000
166WDFY3WD repeat and FYVE domain containing 3Blood+3.080.000
167SELMselenoprotein MBlood-3.070.000
168APOBEC3Bapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3BBlood+3.070.000
169KLRC3killer cell lectin-like receptor subfamily C, member 3Blood-3.050.000
170EPHB1EPH receptor B1Blood-3.040.000
171LDLRAD4low density lipoprotein receptor class A domain containing 4Blood-3.030.000
172CLEC4DC-type lectin domain family 4, member DBlood+3.030.000
173MGAMmaltase-glucoamylaseBlood+3.020.000
174TGFBItransforming growth factor, beta-induced, 68kDaBlood-3.020.000
175MAPK14mitogen-activated protein kinase 14Blood+3.020.000
176NHSNance-Horan syndrome (congenital cataracts and dental anomalies)Blood-3.010.000
177C2complement component 2Blood+3.010.000
178MKNK1MAP kinase interacting serine/threonine kinase 1Blood+3.010.000
179PLSCR4phospholipid scramblase 4Blood+3.010.000
180CABP5calcium binding protein 5Blood-3.000.000
181FAM225Afamily with sequence similarity 225, member A (non-protein coding)Blood+3.000.000

Search GEO for disease gene expression data for Melioidosis.

Pathways for genes affiliated with Melioidosis

About this section

Pathways related to Melioidosis according to GeneCards Suite gene sharing:

(show all 49)
idSuper pathwaysScoreTop Affiliating Genes
19.8LY96, TLR4
29.8LY96, TLR4
39.8IFNG, IL18
49.8IFNG, IL18
59.6IFNG, IL6
6
Show member pathways
9.5IL6, TLR2, TLR5
79.3IFNG, IL6, TLR4
89.3IFNG, IL6, TLR4
99.3IFNG, IL10
109.2IFNG, IL18, TLR2, TLR4
119.1IRAK3, LY96, TLR4
128.9IFNG, IL10, IL18
138.9IL10, IL6, TLR4
148.8IFNG, IL10, IL6
158.8IFNG, IL10, IL6
168.8IFNG, IL10, IL6
178.8IFNG, IL10, IL6
188.8IL18, IL6, TLR2, TLR4, TLR5
198.8TLR1, TLR10, TLR2, TLR4, TLR5
20
Show member pathways
8.8TLR1, TLR10, TLR2, TLR4, TLR5
21
Show member pathways
8.8TLR1, TLR10, TLR2, TLR4, TLR5
22
Show member pathways
8.8TLR1, TLR10, TLR2, TLR4, TLR5
23
Show member pathways
8.7IFNG, IL18, IL6, TLR4, TLR5
248.7IFNG, IL18, IL6, TLR2, TLR4
25
Show member pathways
8.7IFNG, IL18, IL6, TLR2, TLR4
268.5IL10, IL6, LY96, TLR4
278.5IFNG, IL10, IL18, IL6
28
Show member pathways
8.5IFNG, IL10, IL18, IL6
29
Show member pathways
8.5IFNG, IL10, IL18, IL6
30
Show member pathways
8.5IFNG, IL10, IL18, IL6
318.3IL10, IL6, TLR2, TLR4, TLR5
32
Show member pathways
8.3IFNG, IL6, IRAK3, LY96, TLR4
33
Show member pathways
8.3IFNG, IL10, LY96, TLR2, TLR4
348.2IFNG, IL10, IL6, TLR2, TLR4
358.1IFNG, IL10, IRAK3, TLR1, TLR2
368.0IFNG, IL6, TLR1, TLR10, TLR2, TLR4
37
Show member pathways
8.0IFNG, IL6, TLR1, TLR10, TLR2, TLR4
387.9IFNG, IL10, IL18, IL6, TLR2, TLR4
39
Show member pathways
7.8IFNG, IRAK3, TLR1, TLR10, TLR2, TLR4
40
Show member pathways
7.7IRAK3, LY96, TLR1, TLR10, TLR2, TLR4
41
Show member pathways
7.7IL6, IRAK3, TLR1, TLR10, TLR2, TLR4
42
Show member pathways
7.6IFNG, IL10, IL18, IL6, TLR2, TLR4
437.6IFNG, IL10, IL18, IL6, TLR1, TLR2
44
Show member pathways
7.6IL18, IL6, LY96, TLR1, TLR10, TLR2
45
Show member pathways
7.4IFNG, IL6, IRAK3, LY96, TLR1, TLR2
46
Show member pathways
7.2IFNG, IL10, IL6, LY96, TLR1, TLR2
47
Show member pathways
6.8IFNG, IL10, IL18, IL6, TLR1, TLR10
48
Show member pathways
6.6IFNG, IL18, IL6, IRAK3, LY96, TLR1
49
Show member pathways
6.5IL10, IL18, IL6, IRAK3, TLR1, TLR10

GO Terms for genes affiliated with Melioidosis

About this section

Cellular components related to Melioidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:00353549.9TLR1, TLR2
2intrinsic component of plasma membraneGO:00312269.7LY96, TLR2, TLR4
3lipopolysaccharide receptor complexGO:00466969.7LY96, TLR4
4extracellular spaceGO:00056158.0HABP2, IFNG, IL10, IL18, IL6, LY96

Biological processes related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:007122310.7TLR2, TLR4
2I-kappaB phosphorylationGO:000725210.7TLR2, TLR4
3cellular response to triacyl bacterial lipopeptideGO:007172710.7TLR1, TLR2
4detection of triacyl bacterial lipopeptideGO:004249510.6TLR1, TLR2
5positive regulation of toll-like receptor signaling pathwayGO:003412310.6TLR2, TLR5
6positive regulation of interferon-beta productionGO:003272810.6TLR2, TLR4
7positive regulation of interleukin-10 productionGO:003273310.6TLR2, TLR4
8positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.6TLR2, TLR4
9macrophage activationGO:004211610.6TLR1, TLR4
10negative regulation of interleukin-17 productionGO:003270010.6IFNG, TLR4
11detection of lipopolysaccharideGO:003249710.5LY96, TLR4
12positive regulation of interleukin-12 biosynthetic processGO:004508410.5IFNG, TLR4
13MyD88-independent toll-like receptor signaling pathwayGO:000275610.5LY96, TLR4
14necroptotic processGO:007026610.5LY96, TLR4
15negative regulation of MyD88-independent toll-like receptor signaling pathwayGO:003412810.5LY96, TLR4
16positive regulation of interleukin-6 biosynthetic processGO:004541010.5IFNG, TLR1
17positive regulation of tumor necrosis factor biosynthetic processGO:004253510.5TLR1, TLR4
18neutrophil apoptotic processGO:000178110.4IFNG, IL6
19positive regulation of interleukin-8 productionGO:003275710.4TLR2, TLR4, TLR5
20T-helper 1 type immune responseGO:004208810.3IL18, TLR4
21positive regulation of NF-kappaB import into nucleusGO:004234610.3IL18, TLR2, TLR4
22toll-like receptor TLR1:TLR2 signaling pathwayGO:003812310.3TLR1, TLR2
23positive regulation of interleukin-12 productionGO:003273510.3IFNG, TLR2, TLR4
24toll-like receptor 4 signaling pathwayGO:003414210.2LY96, TLR4
25defense response to Gram-negative bacteriumGO:005082910.2IL6, TLR4, TLR5
26positive regulation of chemokine productionGO:003272210.2IL6, TLR2, TLR4
27positive regulation of interleukin-6 productionGO:003275510.2IL6, TLR2, TLR4
28negative regulation of interferon-gamma productionGO:003268910.1IL10, TLR4
29negative regulation of growth of symbiont in hostGO:004413010.0IFNG, IL10
30cellular response to hepatocyte growth factor stimulusGO:003572910.0IL10, IL6
31positive regulation of JAK-STAT cascadeGO:00464279.9IL10, IL6
32response to peptidoglycanGO:00324949.9IL6, IRAK3
33lipopolysaccharide-mediated signaling pathwayGO:00316639.9IL18, LY96, TLR2, TLR4
34TRIF-dependent toll-like receptor signaling pathwayGO:00356669.9LY96, TLR4
35positive regulation of nitric oxide biosynthetic processGO:00454299.8IFNG, IL6, TLR4, TLR5
36negative regulation of interleukin-12 productionGO:00326959.8IL10, IRAK3
37positive regulation of inflammatory responseGO:00507299.8IL18, TLR10, TLR2, TLR4
38positive regulation of tumor necrosis factor productionGO:00327609.7IFNG, LY96, TLR2, TLR4
39positive regulation of MHC class II biosynthetic processGO:00453489.7IFNG, IL10, TLR4
40defense response to protozoanGO:00428329.6IFNG, IL10, IL6
41positive regulation of NF-kappaB transcription factor activityGO:00510929.5IL6, IRAK3, TLR2, TLR4
42response to insulinGO:00328689.5IL10, IL6, TLR2
43negative regulation of interleukin-6 productionGO:00327159.5IL10, IRAK3, TLR4
44negative regulation of tumor necrosis factor productionGO:00327209.5IL10, IRAK3, TLR4
45toll-like receptor signaling pathwayGO:00022249.5TLR1, TLR10, TLR2, TLR4
46positive regulation of gene expressionGO:00106289.5IFNG, IL18, IL6, TLR2, TLR4
47defense response to bacteriumGO:00427429.4IFNG, IL10, TLR1, TLR4
48regulation of cytokine secretionGO:00507079.4TLR1, TLR10, TLR2, TLR4, TLR5
49type 2 immune responseGO:00420929.3IL10, IL18
50innate immune responseGO:00450879.1LY96, TLR1, TLR10, TLR2, TLR4, TLR5

Molecular functions related to Melioidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:000153010.5TLR2, TLR4
2lipopeptide bindingGO:007172310.5TLR1, TLR2
3lipopolysaccharide receptor activityGO:000187510.1LY96, TLR2, TLR4
4receptor activityGO:00048729.9TLR1, TLR2, TLR4, TLR5
5cytokine activityGO:00051259.1IFNG, IL10, IL18, IL6
6transmembrane signaling receptor activityGO:00048888.8TLR1, TLR10, TLR2, TLR4, TLR5

Sources for Melioidosis

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2CDC
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