Melioidosis malady

Infectious diseases, Immune diseases categories

Summaries for Melioidosis

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Disease Ontology:9 A primary bacterial infectious disease that results in infection, has material basis in burkholderia pseudomallei, which is transmitted by contact with the contaminated water or soil. the infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.

MalaCards based summary: Melioidosis, also known as whitmore's disease, is related to pneumonia and sepsis, and has symptoms including fever, respiratory distress and chest pain. An important gene associated with Melioidosis is TLR5 (toll-like receptor 5), and among its related pathways are IL-17 Family Signaling Pathways and Development Slit Robo signaling. The compounds asialo gm1 and arabinogalactan have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and skin, and related mouse phenotypes are adipose tissue and liver/biliary system.

CDC:4 Melioidosis, also called Whitmore's disease, is an infectious disease that can infect humans or animals. The disease is caused by the bacterium Burkholderia pseudomallei.

Wikipedia:64 Melioidosis is an infectious disease caused by a Gram-negative bacterium, Burkholderia pseudomallei,... more...

Aliases & Classifications for Melioidosis

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9Disease Ontology, 11DISEASES, 44Novoseek, 61UMLS, 56SNOMED-CT, 28ICD9CM, 34MeSH, 26ICD10
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Melioidosis, Aliases & Descriptions:

Name: Melioidosis 9 11 44 61
Whitmore's Disease 9 61
Acute and Fulminating Melioidosis 9
Subacute and Chronic Melioidosis 9
Nightcliff Gardener's Disease 9
Melioidosis, Unspecified 9
Epizootic Lymphangitis 61
Pseudoglanders 9


Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Immune diseases

External Ids:

Disease Ontology9 DOID:5052
ICD9CM28 025
MeSH34 D008554

Related Diseases for Melioidosis

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Graphical network of the top 20 diseases related to Melioidosis:

Diseases related to melioidosis

Symptoms for Melioidosis

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  • fever
  • respiratory distress
  • chest pain
  • stomach pain

Drugs & Therapeutics for Melioidosis

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Drug clinical trials:

Search ClinicalTrials for Melioidosis

Search NIH Clinical Center for Melioidosis

Genetic Tests for Melioidosis

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Anatomical Context for Melioidosis

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MalaCards organs/tissues related to Melioidosis:

Bone, Lung, Skin, Testes, Liver, T cells, Prostate, Whole blood, Breast, Spleen, Brain, Spinal cord, Kidney, Myeloid, Monocytes, Endothelial, Neutrophil

Animal Models for Melioidosis or affiliated genes

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MGI Mouse Phenotypes related to Melioidosis:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0TLR5, TLR4, TLR2
2MP:00053708.9TLR2, TLR4, TLR5
3MP:00053818.9TLR5, TLR4, TLR2
4MP:00053888.6TLR2, TLR4, TLR5
5MP:00053978.5TLR2, TLR4, TLR5, IRAK3
6MP:00053878.4IRAK3, TLR5, TLR4, TLR2
7MP:00053788.3IRAK3, TLR5, TLR4, TLR2

Publications for Melioidosis

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Articles related to Melioidosis:

(show top 50)    (show all 520)
The Role of NOD2 in Murine and Human Melioidosis. (24298015)
Induction of mouse melioidosis with meningitis by CD11b+ phagocytic cells harboring intracellular B. pseudomallei as a Trojan horse. (23951382)
Melioidosis: refining management of a tropical time bomb. (24284288)
Antimicrobial Prophylaxis For Melioidosis and Leptospirosis For At Risk Rescue Workers. (23466779)
Melioidosis from contaminated bore water and successful UV sterilization. (23751401)
Melioidosis as a consequence of sporting activity. (23732257)
Expect the unexpected: pleuro-pulmonary melioidosis in a renal transplant recipient. (23278969)
Clinically lesser known entity in India: A Report of two cases of Melioidosis. (23833477)
Activities of daily living associated with acquisition of melioidosis in northeast Thailand: a matched case-control study. (23437412)
Melioidosis breast abscesses. (22285589)
Melioidosis in animals, Thailand, 2006-2010. (22304782)
Outbreak of melioidosis and leptospirosis co-infection following a rescue operation. (23082420)
Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders. (22912938)
BLF1, the first Burkholderia pseudomallei toxin, connects inhibition of host protein synthesis with melioidosis. (22817745)
Imported melioidosis in France revealed by a cracking abdominal mycotic aortic aneurysm in a 61-year-old man. (22962397)
Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis. (20837078)
Radiological manifestations of melioidosis. (20103424)
Imported melioidosis in Danish travellers: a diagnostic challenge. (20297927)
Burkholderia thailandensis whole cell antigen cross-reacts with B. pseudomallei antibodies from patients with melioidosis in an immunofluorescent assay. (20578523)
Defining the true sensitivity of culture for the diagnosis of melioidosis using Bayesian latent class models. (20830194)
Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis. (19903332)
The molecular and cellular basis of pathogenesis in melioidosis: how does Burkholderia pseudomallei cause disease? (19732156)
Melioidosis in a tropical city state, Singapore. (19861063)
In vitro interactions between cotrimoxazole and doxycycline in Burkholderia pseudomallei: how important is this combination in maintenance therapy of melioidosis? (19172079)
Non-septicemic melioidosis presenting as cardiac tamponade. (18784243)
Rheumatological manifestations in patients with melioidosis. (19058601)
Cases of melioidosis in a university teaching hospital in Malaysia. (18473106)
Melioidosis--an unusual cause of septic arthritis. (18506568)
Evaluation of recombinant antigens for diagnosis of melioidosis. (18657105)
Serum C-reactive protein and liver disease in patients with melioidosis. (17262186)
Misdiagnosing melioidosis. (17479916)
Melioidosis outbreak after typhoon, southern Taiwan. (17553230)
Melioidosis: an under-diagnosed entity in western coastal India: a clinico-microbiological analysis. (17901643)
Accuracy of enzyme-linked immunosorbent assay using crude and purified antigens for serodiagnosis of melioidosis. (17093104)
Melioidosis and rainfall in Kuala Lumpur, Malaysia. (16965821)
Role of selective and nonselective media for isolation of Burkholderia pseudomallei from throat swabs of patients with melioidosis. (16757651)
Imported melioidosis--South Florida, 2005. (16915220)
Fatal septicemic melioidosis in a young military person possibly co-infected with Leptospira interrogans and Orientia tsutsugamushi. (15909673)
Melioidosis of the spleen diagnosed by 16S rDNA amplification and sequencing. (16012017)
Antibodies from patients with melioidosis recognize Burkholderia mallei but not Burkholderia thailandensis antigens in the indirect hemagglutination assay. (16145163)
Melioidosis in Pahang, Malaysia. (16515112)
Melioidosis and the vascular surgeon: Hospital Kuala Lumpur experience. (16234087)
Clinical presentation of melioidosis in Queensland, Australia. (16111729)
Melioidosis in animals: a review on epizootiology, diagnosis and clinical presentation. (15525357)
Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei. (12734250)
Melioidosis presenting as an infected intrathoracic subclavian artery pseudoaneurysm treated with femoral vein interposition graft. (11877708)
Melioidosis vaccines. (12901586)
Cutaneous melioidosis. (12139670)
Randomized, double-blind, controlled study of cefoperazone-sulbactam plus cotrimoxazole versus ceftazidime plus cotrimoxazole for the treatment of severe melioidosis. (11389491)
Immune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein. (1902247)

Variations for Melioidosis

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Expression for genes affiliated with Melioidosis

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2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Melioidosis patients vs. healthy controls: 31 (show all 400)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CD177CD177 moleculeBlood+8.410.000
2ZDHHC19zinc finger, DHHC-type containing 19Blood+6.910.000
3MMP8matrix metallopeptidase 8 (neutrophil collagenase)Blood+6.490.000
4SLC51Asolute carrier family 51, alpha subunitBlood+6.460.000
6FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptideBlood-6.000.000
7GPR84G protein-coupled receptor 84Blood+5.860.000
8ANKRD22ankyrin repeat domain 22Blood+5.720.000
9OLAHoleoyl-ACP hydrolaseBlood+5.540.000
10LRRN3leucine rich repeat neuronal 3Blood-5.510.000
11PCOLCE2procollagen C-endopeptidase enhancer 2Blood+5.470.000
12C1QCcomplement component 1, q subcomponent, C chainBlood+5.420.000
13PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2Blood+5.390.000
14CCNA1cyclin A1Blood+5.140.000
15C1QBcomplement component 1, q subcomponent, B chainBlood+5.090.000
16LINC00668long intergenic non-protein coding RNA 668Blood+4.990.000
17CACNA1Ecalcium channel, voltage-dependent, R type, alpha 1E subunitBlood+4.980.000
18FGF13fibroblast growth factor 13Blood+4.960.000
19NOVnephroblastoma overexpressedBlood-4.840.000
20PLVAPplasmalemma vesicle associated proteinBlood-4.760.000
22SLCO4A1solute carrier organic anion transporter family, member 4A1Blood+4.730.000
23MYO10myosin XBlood+4.680.000
24SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3Blood+4.680.000
25RPGRIP1retinitis pigmentosa GTPase regulator interacting protein 1Blood-4.670.000
27CD274CD274 moleculeBlood+4.440.000
28C19orf59chromosome 19 open reading frame 59Blood+4.440.000
29BMXBMX non-receptor tyrosine kinaseBlood+4.410.000
30SERPINA1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1Blood+4.380.000
31CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)Blood+4.380.000
32GRB10growth factor receptor-bound protein 10Blood+4.370.000
33CACNA2D3calcium channel, voltage-dependent, alpha 2/delta subunit 3Blood-4.250.000
34LINC01220long intergenic non-protein coding RNA 1220Blood+4.200.000
36SLC26A8solute carrier family 26 (anion exchanger), member 8Blood+4.180.000
37ARG1arginase 1Blood+4.170.000
38IL18R1interleukin 18 receptor 1Blood+4.170.000
39IL1R2interleukin 1 receptor, type IIBlood+4.080.000
40SLC2A11solute carrier family 2 (facilitated glucose transporter), member 11Blood+4.060.000
41CFHcomplement factor HBlood+4.030.000
42G0S2G0/G1switch 2Blood+4.020.000
43MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Blood+3.970.000
44FCARFc fragment of IgA, receptor forBlood+3.940.000
45SCN9Asodium channel, voltage-gated, type IX, alpha subunitBlood+3.940.000
46FAM20Afamily with sequence similarity 20, member ABlood+3.940.000
47KRTAP19-6keratin associated protein 19-6Blood+3.930.000
48TDRD9tudor domain containing 9Blood+3.920.000
49KREMEN1kringle containing transmembrane protein 1Blood+3.860.000
50HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7Blood+3.840.000
51CR1complement component (3b/4b) receptor 1 (Knops blood group)Blood+3.830.000
52VNN1vanin 1Blood+3.820.000
53LGALSLlectin, galactoside-binding-likeBlood-3.810.000
54COL17A1collagen, type XVII, alpha 1Blood+3.810.000
55NELL2NEL-like 2 (chicken)Blood-3.790.000
56SLAMF8SLAM family member 8Blood+3.790.000
57ELOVL4ELOVL fatty acid elongase 4Blood-3.760.000
58BATF2basic leucine zipper transcription factor, ATF-like 2Blood+3.760.000
59C1QAcomplement component 1, q subcomponent, A chainBlood+3.750.000
60ANKRD34Bankyrin repeat domain 34BBlood+3.740.000
61NTSR1neurotensin receptor 1 (high affinity)Blood+3.740.000
62NAIPNLR family, apoptosis inhibitory proteinBlood+3.740.000
63TNFAIP8L3tumor necrosis factor, alpha-induced protein 8-like 3Blood+3.720.000
64FLJ11292uncharacterized protein FLJ11292Blood+3.720.000
66PTGDR2prostaglandin D2 receptor 2Blood-3.680.000
67BCL6B-cell CLL/lymphoma 6Blood+3.660.000
68IL5RAinterleukin 5 receptor, alphaBlood-3.660.000
69METTL7Bmethyltransferase like 7BBlood+3.650.000
70PTGDRprostaglandin D2 receptor (DP)Blood-3.630.000
71CD160CD160 moleculeBlood-3.620.000
72GALNT14polypeptide N-acetylgalactosaminyltransferase 14Blood+3.600.000
73AP3B2adaptor-related protein complex 3, beta 2 subunitBlood+3.580.000
74GCATglycine C-acetyltransferaseBlood-3.580.000
75ANXA3annexin A3Blood+3.560.000
76DAAM2dishevelled associated activator of morphogenesis 2Blood+3.550.000
77CLEC4CC-type lectin domain family 4, member CBlood-3.550.000
78CD248CD248 molecule, endosialinBlood-3.550.000
79SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 1Blood+3.540.000
80TCN2transcobalamin IIBlood+3.540.000
81PLEKHG4pleckstrin homology domain containing, family G (with RhoGef domain) member 4Blood-3.530.000
82GBP6guanylate binding protein family, member 6Blood+3.530.000
83HDChistidine decarboxylaseBlood-3.520.000
84TCTEX1D1Tctex1 domain containing 1Blood+3.520.000
85LINC00937long intergenic non-protein coding RNA 937Blood+3.510.000
86PID1phosphotyrosine interaction domain containing 1Blood-3.500.000
87PIM3pim-3 oncogeneBlood+3.490.000
88CD3DCD3d molecule, delta (CD3-TCR complex)Blood-3.480.000
89CARD17caspase recruitment domain family, member 17Blood+3.470.000
90MAP2K6mitogen-activated protein kinase kinase 6Blood+3.450.000
91SUPT3Hsuppressor of Ty 3 homolog (S. cerevisiae)Blood-3.430.000
92BPIbactericidal/permeability-increasing proteinBlood+3.420.000
93LIPMlipase, family member MBlood+3.420.000
94LGALS2lectin, galactoside-binding, soluble, 2Blood-3.420.000
95KLHL3kelch-like family member 3Blood-3.400.000
96UGCGUDP-glucose ceramide glucosyltransferaseBlood+3.400.000
97SPINK2serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)Blood-3.400.000
98OLIG2oligodendrocyte lineage transcription factor 2Blood-3.390.000
99KCNJ15potassium inwardly-rectifying channel, subfamily J, member 15Blood+3.390.000
100DBPD site of albumin promoter (albumin D-box) binding proteinBlood-3.380.000
101PRSS23protease, serine, 23Blood-3.380.000
102MUC1mucin 1, cell surface associatedBlood+3.370.000
103NT5E5'-nucleotidase, ecto (CD73)Blood-3.360.000
105UG0898H09uncharacterized LOC643763Blood+3.350.000
106ZNF69zinc finger protein 69Blood-3.350.000
107AIM2absent in melanoma 2Blood+3.340.000
108PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3Blood+3.310.000
109DNASE1L3deoxyribonuclease I-like 3Blood-3.310.000
110FHITfragile histidine triadBlood-3.310.000
111MT1Gmetallothionein 1GBlood+3.300.000
113CFBcomplement factor BBlood+3.300.000
114MIR205HGMIR205 host gene (non-protein coding)Blood+3.300.000
115KIF20Akinesin family member 20ABlood+3.290.000
116LINC00342long intergenic non-protein coding RNA 342Blood+3.290.000
117GSTM1glutathione S-transferase mu 1Blood-3.290.000
118NECAB1N-terminal EF-hand calcium binding protein 1Blood+3.270.000
119HGFhepatocyte growth factor (hepapoietin A; scatter factor)Blood+3.260.000
120CEACAM8carcinoembryonic antigen-related cell adhesion molecule 8Blood+3.260.000
121TMOD3tropomodulin 3 (ubiquitous)Blood+3.240.000
122SIGLEC17Psialic acid binding Ig-like lectin 17, pseudogeneBlood-3.240.000
123APOL1apolipoprotein L, 1Blood+3.240.000
124HLA-DQB1major histocompatibility complex, class II, DQ beta 1Blood-3.240.000
125MS4A4Amembrane-spanning 4-domains, subfamily A, member 4ABlood+3.230.000
126OLFM1olfactomedin 1Blood-3.230.000
127ENTPD7ectonucleoside triphosphate diphosphohydrolase 7Blood+3.220.000
128GPR141G protein-coupled receptor 141Blood+3.220.000
129ZAKsterile alpha motif and leucine zipper containing kinase AZKBlood+3.220.000
130EDARectodysplasin A receptorBlood-3.210.000
131IL27interleukin 27Blood+3.210.000
132OPLAH5-oxoprolinase (ATP-hydrolysing)Blood+3.210.000
133OLFM4olfactomedin 4Blood+3.200.000
134TNFAIP6tumor necrosis factor, alpha-induced protein 6Blood+3.200.000
135TIFATRAF-interacting protein with forkhead-associated domainBlood+3.190.000
136IRAK3interleukin-1 receptor-associated kinase 3Blood+3.190.000
137DTX3deltex 3, E3 ubiquitin ligaseBlood-3.190.000
138VSIG4V-set and immunoglobulin domain containing 4Blood+3.190.000
139PDCD1LG2programmed cell death 1 ligand 2Blood+3.190.000
140LILRA5leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5Blood+3.190.000
141S100A12S100 calcium binding protein A12Blood+3.190.000
142SOCS3suppressor of cytokine signaling 3Blood+3.180.000
143VIPR1vasoactive intestinal peptide receptor 1Blood-3.170.000
144EBI3Epstein-Barr virus induced 3Blood+3.170.000
145ENKURenkurin, TRPC channel interacting proteinBlood-3.150.000
146LIMK2LIM domain kinase 2Blood+3.150.000
147CCDC65coiled-coil domain containing 65Blood-3.150.000
148FBLN2fibulin 2Blood-3.150.000
149LRRN1leucine rich repeat neuronal 1Blood+3.150.000
150APOL6apolipoprotein L, 6Blood+3.140.000
151ACVR1Bactivin A receptor, type IBBlood+3.140.000
152CPA3carboxypeptidase A3 (mast cell)Blood-3.140.000
153KLF5Kruppel-like factor 5 (intestinal)Blood+3.140.000
154CD1CCD1c moleculeBlood-3.120.000
156CD8BCD8b moleculeBlood-3.120.000
157LINC01138long intergenic non-protein coding RNA 1138Blood+3.110.000
158LYRM4LYR motif containing 4Blood-3.100.000
159KIF1Bkinesin family member 1BBlood+3.100.000
160EPHA4EPH receptor A4Blood-3.090.000
161SLC2A14solute carrier family 2 (facilitated glucose transporter), member 14Blood+3.090.000
162CCR3chemokine (C-C motif) receptor 3Blood-3.090.000
163SFTPDsurfactant protein DBlood-3.090.000
164HIST2H2ABhistone cluster 2, H2abBlood+3.080.000
165RALGAPA2Ral GTPase activating protein, alpha subunit 2 (catalytic)Blood+3.080.000
166WDFY3WD repeat and FYVE domain containing 3Blood+3.080.000
167SELMselenoprotein MBlood-3.070.000
168APOBEC3Bapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3BBlood+3.070.000
169KLRC3killer cell lectin-like receptor subfamily C, member 3Blood-3.050.000
170EPHB1EPH receptor B1Blood-3.040.000
171LDLRAD4low density lipoprotein receptor class A domain containing 4Blood-3.030.000
172CLEC4DC-type lectin domain family 4, member DBlood+3.030.000
173MGAMmaltase-glucoamylase (alpha-glucosidase)Blood+3.020.000
174TGFBItransforming growth factor, beta-induced, 68kDaBlood-3.020.000
175MAPK14mitogen-activated protein kinase 14Blood+3.020.000
176NHSNance-Horan syndrome (congenital cataracts and dental anomalies)Blood-3.010.000
177C2complement component 2Blood+3.010.000
178MKNK1MAP kinase interacting serine/threonine kinase 1Blood+3.010.000
179PLSCR4phospholipid scramblase 4Blood+3.010.000
180CABP5calcium binding protein 5Blood-3.000.000
181FAM225Afamily with sequence similarity 225, member A (non-protein coding)Blood+3.000.000
182TKTL1transketolase-like 1Blood-3.000.000
183GCSAMgerminal center-associated, signaling and motilityBlood-2.990.000
184UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)Blood+2.990.000
185GPSM1G-protein signaling modulator 1Blood-2.990.000
186ATP6V1C1ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1Blood+2.980.000
187GATA3GATA binding protein 3Blood-2.980.000
189DISC1disrupted in schizophrenia 1Blood+2.980.000
190ADCY3adenylate cyclase 3Blood+2.980.000
191C2orf15chromosome 2 open reading frame 15Blood-2.970.000
192SAMSN1SAM domain, SH3 domain and nuclear localization signals 1Blood+2.960.000
193ZNF285zinc finger protein 285Blood-2.960.000
194MMP23Amatrix metallopeptidase 23A (pseudogene)Blood-2.960.000
195SMPDL3Asphingomyelin phosphodiesterase, acid-like 3ABlood+2.960.000
196FAM151Bfamily with sequence similarity 151, member BBlood+2.960.000
197SULF2sulfatase 2Blood-2.950.000
198PTPDC1protein tyrosine phosphatase domain containing 1Blood-2.950.000
199TLR5toll-like receptor 5Blood+2.950.000
200PRSS33protease, serine, 33Blood-2.940.000
201AXIN2axin 2Blood-2.930.000
202PNMA3paraneoplastic Ma antigen 3Blood-2.930.000
203CXCR5chemokine (C-X-C motif) receptor 5Blood-2.930.000
204FFAR3free fatty acid receptor 3Blood+2.930.000
205HBE1hemoglobin, epsilon 1Blood+2.930.000
206FKBP5FK506 binding protein 5Blood+2.920.000
207SCARF1scavenger receptor class F, member 1Blood+2.920.000
208RAB20RAB20, member RAS oncogene familyBlood+2.920.000
209DHRS3dehydrogenase/reductase (SDR family) member 3Blood-2.920.000
210CEP55centrosomal protein 55kDaBlood+2.920.000
211IL11RAinterleukin 11 receptor, alphaBlood-2.920.000
212LOC728519NLR family, apoptosis inhibitory protein pseudogeneBlood+2.910.000
213SLC22A17solute carrier family 22, member 17Blood+2.910.000
214PCSK1Nproprotein convertase subtilisin/kexin type 1 inhibitorBlood-2.910.000
216IFI27interferon, alpha-inducible protein 27Blood+2.900.000
217ABCF2ATP-binding cassette, sub-family F (GCN20), member 2Blood-2.900.000
218FBXL16F-box and leucine-rich repeat protein 16Blood-2.900.000
219ZNF683zinc finger protein 683Blood-2.890.000
220PLCG1phospholipase C, gamma 1Blood-2.890.000
221PLSCR1phospholipid scramblase 1Blood+2.880.000
222LINC01181long intergenic non-protein coding RNA 1181Blood-2.880.000
223IFITM3interferon induced transmembrane protein 3Blood+2.880.000
224PYROXD2pyridine nucleotide-disulphide oxidoreductase domain 2Blood-2.880.000
225C15orf48chromosome 15 open reading frame 48Blood+2.870.000
226SLC29A2solute carrier family 29 (equilibrative nucleoside transporter), member 2Blood-2.870.000
227C16orf74chromosome 16 open reading frame 74Blood-2.860.000
228TBC1D4TBC1 domain family, member 4Blood-2.860.000
229TRIM51tripartite motif-containing 51Blood-2.850.000
230IMMP2LIMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)Blood-2.850.000
231CKAP4cytoskeleton-associated protein 4Blood+2.850.000
232DNAH12dynein, axonemal, heavy chain 12Blood-2.840.000
233NEDD4neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligaseBlood+2.840.000
234CD3ECD3e molecule, epsilon (CD3-TCR complex)Blood-2.830.000
235DNAAF1dynein, axonemal, assembly factor 1Blood+2.830.000
236CLEC5AC-type lectin domain family 5, member ABlood+2.830.000
237EPHA1EPH receptor A1Blood-2.830.000
238SERPINA13Pserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 13, pseudogeneBlood-2.830.000
239ZNF385Azinc finger protein 385ABlood-2.830.000
240ANO9anoctamin 9Blood-2.820.000
241PRTN3proteinase 3Blood+2.820.000
242PNPLA1patatin-like phospholipase domain containing 1Blood+2.820.000
243VSIG1V-set and immunoglobulin domain containing 1Blood-2.820.000
244DACH1dachshund family transcription factor 1Blood+2.820.000
245LOC729033putative uncharacterized protein FLJ44672-likeBlood+2.810.000
246LY9lymphocyte antigen 9Blood-2.810.000
247RTN3reticulon 3Blood+2.800.000
248CA4carbonic anhydrase IVBlood+2.800.000
249LOC441081POM121 membrane glycoprotein (rat) pseudogeneBlood+2.800.000
250ABCA13ATP-binding cassette, sub-family A (ABC1), member 13Blood+2.790.000
251CHI3L2chitinase 3-like 2Blood-2.790.000
252CNTNAP2contactin associated protein-like 2Blood-2.790.000
253RP5-1166F10.1uncharacterized LOC284661Blood+2.790.000
254LRG1leucine-rich alpha-2-glycoprotein 1Blood+2.780.000
255MYL4myosin, light chain 4, alkali; atrial, embryonicBlood-2.780.000
256ZNF32zinc finger protein 32Blood-2.780.000
257MCTP2multiple C2 domains, transmembrane 2Blood+2.770.000
258MCTP1multiple C2 domains, transmembrane 1Blood+2.760.000
259IL15RAinterleukin 15 receptor, alphaBlood+2.750.000
260TBC1D8TBC1 domain family, member 8 (with GRAM domain)Blood+2.750.000
261CYP1B1cytochrome P450, family 1, subfamily B, polypeptide 1Blood+2.750.000
262CRIP2cysteine-rich protein 2Blood-2.750.000
263TGM3transglutaminase 3Blood-2.750.000
264NSG1neuron specific gene family member 1Blood-2.750.000
265RLTPRRGD motif, leucine rich repeats, tropomodulin domain and proline-rich containingBlood-2.740.000
266CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)Blood+2.740.000
267CLYBLcitrate lyase beta likeBlood-2.740.000
268CAMK2N1calcium/calmodulin-dependent protein kinase II inhibitor 1Blood-2.730.000
269HES4hes family bHLH transcription factor 4Blood-2.730.000
270RGRretinal G protein coupled receptorBlood+2.730.000
271PASKPAS domain containing serine/threonine kinaseBlood-2.730.000
272MOB3BMOB kinase activator 3BBlood-2.720.000
273RNF213ring finger protein 213Blood+2.720.000
274ZDHHC1zinc finger, DHHC-type containing 1Blood-2.720.000
275HRKharakiri, BCL2 interacting proteinBlood-2.720.000
276LINC00858long intergenic non-protein coding RNA 858Blood+2.720.000
277CR2complement component (3d/Epstein Barr virus) receptor 2Blood-2.720.000
278GPC2glypican 2Blood-2.720.000
279ALOX5arachidonate 5-lipoxygenaseBlood+2.720.000
280BACH2BTB and CNC homology 1, basic leucine zipper transcription factor 2Blood-2.710.000
281RLN2relaxin 2Blood-2.710.000
282PSTPIP2proline-serine-threonine phosphatase interacting protein 2Blood+2.710.000
283BCL11BB-cell CLL/lymphoma 11B (zinc finger protein)Blood-2.710.000
284SOCS1suppressor of cytokine signaling 1Blood+2.710.000
285ZAP70zeta-chain (TCR) associated protein kinase 70kDaBlood-2.700.000
286NLRC4NLR family, CARD domain containing 4Blood+2.700.000
287SH2D1BSH2 domain containing 1BBlood-2.700.000
288HSF5heat shock transcription factor family member 5Blood-2.700.000
289HPCAL4hippocalcin like 4Blood-2.690.000
290LCN2lipocalin 2Blood+2.690.000
291CLEC6AC-type lectin domain family 6, member ABlood+2.690.000
292AK5adenylate kinase 5Blood-2.690.000
293FAAHfatty acid amide hydrolaseBlood-2.690.000
294TCEA3transcription elongation factor A (SII), 3Blood-2.690.000
295FAIM3Fas apoptotic inhibitory molecule 3Blood-2.690.000
296ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix proteinBlood-2.680.000
297PDZD4PDZ domain containing 4Blood-2.680.000
299B3GNT5UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5Blood+2.670.000
300EMR3egf-like module containing, mucin-like, hormone receptor-like 3Blood-2.670.000
301PTGR1prostaglandin reductase 1Blood+2.670.000
302SPIBSpi-B transcription factor (Spi-1/PU.1 related)Blood-2.670.000
303FAM89Afamily with sequence similarity 89, member ABlood+2.670.000
304ABLIM1actin binding LIM protein 1Blood-2.660.000
305RNF182ring finger protein 182Blood+2.660.001
306GZMMgranzyme M (lymphocyte met-ase 1)Blood-2.660.000
307THAP7THAP domain containing 7Blood-2.660.000
308C2orf40chromosome 2 open reading frame 40Blood-2.660.000
309PLA2G7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)Blood-2.650.000
310ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1Blood-2.650.000
311BTNL3butyrophilin-like 3Blood+2.640.000
312LEF1lymphoid enhancer-binding factor 1Blood-2.640.000
313KCND1potassium voltage-gated channel, Shal-related subfamily, member 1Blood+2.640.000
314GPR183G protein-coupled receptor 183Blood-2.640.000
315CAMK1calcium/calmodulin-dependent protein kinase IBlood-2.630.000
316SIRPGsignal-regulatory protein gammaBlood-2.630.000
317BAZ1Abromodomain adjacent to zinc finger domain, 1ABlood+2.630.000
318WSB1WD repeat and SOCS box containing 1Blood+2.630.000
319JUPjunction plakoglobinBlood-2.620.000
320NEAT1nuclear paraspeckle assembly transcript 1 (non-protein coding)Blood+2.620.000
321SLC27A1solute carrier family 27 (fatty acid transporter), member 1Blood-2.620.000
322NUPL1nucleoporin like 1Blood+2.620.000
323CENPAcentromere protein ABlood+2.620.000
324ASB13ankyrin repeat and SOCS box containing 13Blood-2.620.000
325POLR1Epolymerase (RNA) I polypeptide E, 53kDaBlood-2.610.000
326CD163CD163 moleculeBlood+2.610.000
327TLR2toll-like receptor 2Blood+2.610.000
328AFF3AF4/FMR2 family, member 3Blood-2.610.000
329ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)Blood+2.610.000
330MAN1C1mannosidase, alpha, class 1C, member 1Blood-2.610.000
331NMT2N-myristoyltransferase 2Blood-2.610.000
332CELcarboxyl ester lipaseBlood+2.600.000
333PKD1polycystic kidney disease 1 (autosomal dominant)Blood-2.600.000
334TUBGCP5tubulin, gamma complex associated protein 5Blood-2.600.000
335VPREB3pre-B lymphocyte 3Blood-2.600.000
336MAP3K7CLMAP3K7 C-terminal likeBlood-2.600.000
337SIAEsialic acid acetylesteraseBlood+2.600.000
338SYN2synapsin IIBlood+2.600.000
339ICAM1intercellular adhesion molecule 1Blood+2.600.000
340ERI1exoribonuclease 1Blood+2.590.000
341BMP2bone morphogenetic protein 2Blood+2.590.000
342NCR3natural cytotoxicity triggering receptor 3Blood-2.590.000
343KLRK1killer cell lectin-like receptor subfamily K, member 1Blood-2.590.000
345ATP13A3ATPase type 13A3Blood+2.590.000
346CD4CD4 moleculeBlood-2.580.000
347CYP2S1cytochrome P450, family 2, subfamily S, polypeptide 1Blood-2.580.000
348TPCN1two pore segment channel 1Blood-2.580.000
349GPR162G protein-coupled receptor 162Blood-2.580.000
350C10orf35chromosome 10 open reading frame 35Blood-2.570.000
351FAPfibroblast activation protein, alphaBlood+2.570.000
352IL1R1interleukin 1 receptor, type IBlood+2.570.000
353HLA-DOAmajor histocompatibility complex, class II, DO alphaBlood-2.570.000
354BEND5BEN domain containing 5Blood-2.560.000
355SPON1spondin 1, extracellular matrix proteinBlood-2.560.000
356TDP1tyrosyl-DNA phosphodiesterase 1Blood-2.550.000
357CCNB1IP1cyclin B1 interacting protein 1, E3 ubiquitin protein ligaseBlood-2.550.000
358ZNF543zinc finger protein 543Blood-2.550.000
359PLEKHB1pleckstrin homology domain containing, family B (evectins) member 1Blood-2.540.000
360QTRT1queuine tRNA-ribosyltransferase 1Blood-2.540.000
361ZNF365zinc finger protein 365Blood-2.540.000
362FAM102Afamily with sequence similarity 102, member ABlood-2.540.000
363CYP2U1cytochrome P450, family 2, subfamily U, polypeptide 1Blood-2.540.000
364GGT7gamma-glutamyltransferase 7Blood-2.530.000
365CCDC64coiled-coil domain containing 64Blood-2.530.000
366ATG9Bautophagy related 9BBlood-2.530.000
367RTKN2rhotekin 2Blood-2.520.000
368TMEM261transmembrane protein 261Blood-2.520.000
369ATP6V0E2ATPase, H+ transporting V0 subunit e2Blood-2.520.000
370FXYD1FXYD domain containing ion transport regulator 1Blood-2.520.000
371KLRB1killer cell lectin-like receptor subfamily B, member 1Blood-2.510.000
372SNORD32Asmall nucleolar RNA, C/D box 32ABlood-2.510.000
373TRAT1T cell receptor associated transmembrane adaptor 1Blood-2.510.000
374TASP1taspase, threonine aspartase, 1Blood-2.510.000
375CRYGScrystallin, gamma SBlood-2.510.000
376IL4interleukin 4Blood-2.510.000
377KLRF1killer cell lectin-like receptor subfamily F, member 1Blood-2.510.000
378TMEM204transmembrane protein 204Blood-2.500.000
379CROCCciliary rootlet coiled-coil, rootletinBlood-2.500.000
380SCNN1Dsodium channel, non-voltage-gated 1, delta subunitBlood-2.490.000
381ADTRPandrogen-dependent TFPI-regulating proteinBlood-2.490.000
382PARP15poly (ADP-ribose) polymerase family, member 15Blood-2.490.000
383LTBP4latent transforming growth factor beta binding protein 4Blood-2.490.000
384BCAS4breast carcinoma amplified sequence 4Blood-2.490.000
385PNPLA7patatin-like phospholipase domain containing 7Blood-2.480.000
386FCGBPFc fragment of IgG binding proteinBlood-2.470.000
387SLC27A5solute carrier family 27 (fatty acid transporter), member 5Blood-2.470.000
388NR2C2APnuclear receptor 2C2-associated proteinBlood-2.470.000
389TNFRSF25tumor necrosis factor receptor superfamily, member 25Blood-2.460.000
390GPA33glycoprotein A33 (transmembrane)Blood-2.450.000
391IDUAiduronidase, alpha-L-Blood-2.450.000
392LCKlymphocyte-specific protein tyrosine kinaseBlood-2.450.000
393AGMATagmatine ureohydrolase (agmatinase)Blood-2.440.000
394TNFRSF21tumor necrosis factor receptor superfamily, member 21Blood-2.440.000
395CD1ACD1a moleculeBlood-2.440.000
396FUOMfucose mutarotaseBlood-2.430.000
397CDKN1Ccyclin-dependent kinase inhibitor 1C (p57, Kip2)Blood-2.430.000
398SOX13SRY (sex determining region Y)-box 13Blood-2.430.000
399CDH2cadherin 2, type 1, N-cadherin (neuronal)Blood-2.420.000
400CD300LBCD300 molecule-like family member bBlood-2.420.000

Expression patterns in normal tissues for genes affiliated with Melioidosis

Search GEO for disease gene expression data for Melioidosis.

Pathways for genes affiliated with Melioidosis

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Pathways related to Melioidosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
Show member pathways
9.5TLR5, TLR2
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion59
Pathogenic Escherichia coli infection37
9.4TLR4, TLR5
Show member pathways
9.4TLR5, TLR4
49.3TLR2, TLR4
59.3TLR4, TLR2
69.3TLR4, TLR2
Show member pathways
9.3TLR2, TLR4
89.3TLR2, TLR4
99.3TLR4, TLR2
109.3TLR4, TLR2
Show member pathways
9.3TLR4, IRAK3
Show member pathways
Immune response MIF in innate immunity response59
9.3TLR4, IRAK3
Show member pathways
8.9TLR5, TLR4, TLR2
148.9TLR5, TLR4, TLR2
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.9TLR2, TLR4, TLR5
168.8TLR2, TLR4, IRAK3
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
8.4TLR2, TLR4, TLR5, IRAK3
188.1TLR10, TLR2, TLR4, TLR5
Show member pathways
8.1TLR5, TLR4, TLR2, TLR10
Show member pathways
IL27-mediated signaling events37
8.1TLR10, TLR2, TLR4, TLR5
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.1TLR10, TLR2, TLR4, TLR5
Show member pathways
8.1TLR5, TLR4, TLR2, TLR10
238.1TLR5, TLR4, TLR2, TLR10
Show member pathways
8.1TLR10, TLR2, TLR4, TLR5
Show member pathways
7.5TLR10, TLR2, TLR4, TLR5, IRAK3
Show member pathways
7.5TLR10, TLR2, TLR4, TLR5, IRAK3
Show member pathways
7.5TLR10, TLR2, TLR4, TLR5, IRAK3
Show member pathways
7.5IRAK3, TLR5, TLR4, TLR2, TLR10

Compounds for genes affiliated with Melioidosis

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Compounds related to Melioidosis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1asialo gm1449.9TLR5, TLR2
2arabinogalactan449.7TLR4, TLR2
3diaminopimelic acid449.7TLR2, TLR4
4pam2csk4609.7TLR2, TLR4
5pam3csk4609.7TLR2, TLR4
6poly(i:c)609.7TLR2, TLR4
7glucuronoxylomannan449.7TLR4, TLR2
8resiquimod44 6010.7TLR4, TLR2
9muramyl dipeptide44 2910.7TLR4, TLR2
10hbd2449.7TLR4, TLR2
11lauric acid44 2910.7TLR2, TLR4
12zymosan449.7TLR4, TLR2
13imiquimod44 60 29 1212.7TLR4, TLR2
14mannan449.6TLR2, TLR4
15docosahexaenoic acid44 29 2511.6TLR4, TLR2
16polymyxin b449.6TLR2, TLR4
17polyinosinic-polycytidylic acid449.6TLR4, TLR2
18il 10449.6TLR4, TLR2
19glycolipid449.6TLR2, TLR4
20anti-fungal449.6TLR4, TLR2
21ccl344 2910.6TLR2, TLR4
22latex449.5TLR4, TLR2
23palmitate449.5TLR4, TLR2
24agarose449.4TLR4, TLR2
25simvastatin44 50 60 29 25 1214.3TLR4, TLR2
26calcitriol44 60 25 1212.3TLR4, TLR2
27loxoribine44 2910.3TLR5, TLR4, TLR2
28flagellin44 2910.3TLR5, TLR4, TLR2
29lipoteichoic acid449.3TLR2, TLR4, TLR5
30poly(i-c)449.3TLR5, TLR4, TLR2
31peptidoglycan44 2910.3TLR2, TLR4, TLR5
32mannose449.2TLR2, TLR4
33rantes449.2TLR5, TLR4, TLR2
34endotoxin449.2TLR2, TLR4, IRAK3
35phosphatidylinositol449.1TLR5, TLR4, TLR2
36tacrolimus44 50 1211.0TLR4, TLR2
37atp44 2910.0TLR2, TLR4, TLR5

GO Terms for genes affiliated with Melioidosis

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Cellular components related to Melioidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3TLR4, TLR2

Biological processes related to Melioidosis according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of toll-like receptor signaling pathwayGO:0341239.9TLR2, TLR5
2negative regulation of interleukin-12 productionGO:0326959.8IRAK3, TLR2
3positive regulation of macrophage cytokine productionGO:0609079.7TLR4, TLR2
4cellular response to lipoteichoic acidGO:0712239.7TLR4, TLR2
5negative regulation of interleukin-17 productionGO:0327009.7TLR2, TLR4
6positive regulation of tumor necrosis factor biosynthetic processGO:0425359.7TLR4, TLR2
7positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.7TLR2, TLR4
8I-kappaB phosphorylationGO:0072529.7TLR2, TLR4
9positive regulation of chemokine productionGO:0327229.7TLR4, TLR2
10positive regulation of interleukin-10 productionGO:0327339.7TLR4, TLR2
11positive regulation of NF-kappaB import into nucleusGO:0423469.7TLR2, TLR4
12negative regulation of interleukin-6 productionGO:0327159.7IRAK3, TLR4
13positive regulation of interferon-beta productionGO:0327289.7TLR4, TLR2
14positive regulation of interleukin-12 productionGO:0327359.6TLR4, TLR2
15lipopolysaccharide-mediated signaling pathwayGO:0316639.6TLR2, TLR4
16negative regulation of tumor necrosis factor productionGO:0327209.6IRAK3, TLR4
17positive regulation of nitric oxide biosynthetic processGO:0454299.6TLR4, TLR2
18positive regulation of tumor necrosis factor productionGO:0327609.6TLR2, TLR4
19positive regulation of interleukin-6 productionGO:0327559.6TLR4, TLR2
20cellular response to mechanical stimulusGO:0712609.5TLR5, TLR4
21toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.4TLR2, TLR4
22toll-like receptor 10 signaling pathwayGO:0341669.4TLR10, TLR5
23cellular response to lipopolysaccharideGO:0712229.4TLR5, TLR4
24toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.4TLR2, TLR4
25toll-like receptor 5 signaling pathwayGO:0341469.4TLR10, TLR5
26response to lipopolysaccharideGO:0324969.3IRAK3, TLR4
27positive regulation of interleukin-8 productionGO:0327579.3TLR2, TLR4, TLR5
28toll-like receptor 2 signaling pathwayGO:0341349.2TLR2, TLR4
29positive regulation of NF-kappaB transcription factor activityGO:0510929.2TLR2, TLR4, IRAK3
30toll-like receptor 4 signaling pathwayGO:0341429.0TLR4, TLR2
31inflammatory responseGO:0069549.0TLR10, TLR2, TLR5
32positive regulation of inflammatory responseGO:0507298.9TLR4, TLR2, TLR10
33immune responseGO:0069558.8TLR4, TLR2, TLR10
34toll-like receptor signaling pathwayGO:0022248.5TLR10, TLR2, TLR4, TLR5
35innate immune responseGO:0450878.4TLR5, TLR4, TLR2, TLR10
36MyD88-dependent toll-like receptor signaling pathwayGO:0027557.9IRAK3, TLR5, TLR4, TLR2, TLR10

Molecular functions related to Melioidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:0018759.0TLR4, TLR2
2transmembrane signaling receptor activityGO:0048888.5TLR4, TLR2, TLR10

Products for genes affiliated with Melioidosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Melioidosis

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27ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
62UMLS via Orphanet