Melioidosis disease: symptoms, drugs, articles, genes, clinical trials

Summaries for Melioidosis

Sources:
⁶Disease Ontology, ²CDC, ⁴⁴Wikipedia, ²²MalaCards
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Disease Ontology: A primary bacterial infectious disease that results in infection, has material basis in burkholderia pseudomallei, which is transmitted by contact with the contaminated water or soil. the infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.⁶

MalaCards: Melioidosis, also known as melioidosis, unspecified (disorder), is related to sepsis and septic shock, and has symptoms including fever, respiratory distress and chest pain. An important gene associated with Melioidosis is CXCL9 (chemokine (C-X-C motif) ligand 9), and among its related pathways are Bacterial infections in CF airways and NFAT Signaling and Lymphocyte Interactions. The compounds cyclophosphamide and pge2 have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and myeloid, and related mouse phenotypes are hematopoietic system and renal/urinary system.

CDC: Melioidosis, also called Whitmore's disease, is an infectious disease that can infect humans or animals. The disease is caused by the bacterium Burkholderia pseudomallei.²

Wikipedia: Melioidosis is an infectious disease caused by a Gram-negative bacterium, Burkholderia pseudomallei,...⁴⁴ more...

Aliases & Descriptions for Melioidosis

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Sources:
⁶Disease Ontology, ⁸DISEASES, ³²Novoseek , ²CDC, ⁴³UMLS, ⁴⁰SNOMED-CT, ²⁴MeSH, ¹⁹ICD9CM
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Aliases & Descriptions:

melioidosis ⁶ ⁸ ³² ⁴³

melioidosis, unspecified (disorder) ⁶

acute and fulminating melioidosis ⁶

subacute and chronic melioidosis ⁶

nightcliff gardener's disease ⁶

pseudoglanders (disorder) ⁶

epizootic lymphangitis ⁴³

whitmore's disease ⁶

pseudoglanders ⁶

External Ids:

MeSH²⁴ D008554

SNOMED-CT⁴⁰ 428111003, 187306003, 34458001

ICD9CM¹⁹ 025

UMLS⁴³ C0025229

Related Diseases for Melioidosis

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Sources:
¹³GeneCards, ¹⁴GeneDecks
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Diseases related to melioidosis by text searches and GeneDecks gene sharing:

(show top 50) (show all 508)

id	Related Disease	Score	Top Affiliating Genes
1	sepsis	24.0	IRAK3, MIF, IL10, IL15, IL18, IL1B
2	septic shock	23.7	MIF, IL10, IL1B, IL6, F5, TREM1
3	diabetes mellitus	22.8	MIF, INS, IL10, IL15, IL18, IL1B
4	pneumonia	20.5	MIF, INS, IL10, IL15, IL18, IL1B
5	invasive aspergillosis	13.7	TLR2, TLR4
6	colorectal cancer	13.6	TLR2, TLR4
7	suppurative cholangitis	13.3	TREM1, CRP
8	sydenham's chorea	13.3	CRP, CXCL9
9	pulmonary sarcoidosis	13.3	IL18, CXCL9, CXCR3
10	lymphadenitis	13.2	CRP, CXCL9, CXCR3
11	leprosy	13.1	IL10, TLR1, TLR2
12	chronic eosinophilic pneumonia	13.1	IL10, CXCL9, CXCR3
13	aortitis	13.1	CRP, CSF3
14	endotoxin hyporesponsiveness	13.1	IL1B, TLR2, TLR4
15	lepromatous leprosy	13.1	IL10, TLR2
16	insulin autoimmune syndrome	13.0	INS, F5
17	food allergy	13.0	IL10, TLR2, TLR4
18	leukemoid reaction	13.0	CRP, CSF3
19	scrub typhus	13.0	IL15, IL18, CRP
20	relapsing-remitting multiple sclerosis	13.0	IL10, IL18, CXCR3
21	pulmonary tuberculosis	13.0	IL10, IL18, TLR2
22	cysticercosis	12.9	MIF, IL10, IL18
23	cinca syndrome	12.9	IL18, IL1B
24	typhus	12.9	IL15, IL18, CRP
25	hepatitis b	12.9	IL10, IL18, TLR2
26	rheumatoid arthritis, systemic juvenile	12.9	MIF, IL6
27	plasmodium falciparum malaria	12.9	MIF, IL10, IL18
28	diabetic foot ulcers	12.9	IL15, CRP, CSF3
29	miliary tuberculosis	12.9	IL10, IL18, CSF3
30	polymyositis	12.8	IL15, CRP, TLR2, TLR4
31	allergic asthma	12.8	IL10, IL18, TLR2, TLR4
32	bacterial meningitis	12.8	IL1B, CRP, TLR2
33	behcet's disease	12.8	IL18, F5, CRP
34	psoriatic arthritis	12.8	IL1B, CRP, TLR2
35	proliferative glomerulonephritis	12.7	IL6, CXCL9, CXCR3
36	immunodysregulation	12.7	INS, IL10
37	idiopathic pulmonary fibrosis	12.7	IL18, IL1B, CXCL9, CXCR3
38	meningococcal infection	12.7	IL10, IL1B, TLR4
39	periodic fever	12.7	MIF, IL1B, CRP
40	chronic infantile neurological cutaneous articular syndrome	12.7	IL18, IL1B, CRP
41	tuberculosis	12.7	IL10, IL1B, TLR4
42	nonspecific interstitial pneumonia	12.7	IL18, IL6, CXCR3
43	laryngeal carcinoma	12.7	IL10, IL18, TLR2, TLR4
44	hepatitis c	12.6	IL10, IL18, TLR2, TLR4, CXCR3
45	skin disease	12.6	IL10, IL18, TLR2, CXCL9, CXCR3
46	typhoid fever	12.6	IL1B, CRP, TLR4
47	paracoccidioidomycosis	12.6	IL10, CRP, TLR2, TLR4, CXCL9
48	cerebral malaria	12.6	MIF, IL10, IL1B
49	cold agglutinin disease	12.6	IL6, CRP
50	acute graft versus host disease	12.6	IL10, IL15, IL18, CSF3

Graphical network of the top 20 diseases related to melioidosis:

Graphical network of diseases related to melioidosis

Clinical Features for Melioidosis

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⁶Disease Ontology
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Symptoms: fever, respiratory distress, chest pain, stomach pain.⁶

Drugs & Therapeutics for Melioidosis

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Sources:
⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials, ⁴³UMLS, ²⁸NDF-RT
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Approved drugs:

Search CenterWatch for melioidosis

Drug clinical trials:

Search ClinicalTrials for melioidosis

Search NIH Clinical Center for melioidosis

Search CenterWatch for melioidosis

Genetic Tests for Melioidosis

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Anatomical Context for Melioidosis

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²²MalaCards
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MalaCards organs/tissues related to melioidosis:

²²

Lung, Skin, Myeloid

Phenotypes for genes affiliated with Melioidosis

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²⁵MGI
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MGI Mouse Phenotypes related to melioidosis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.7	CSF3, MIF, IRAK3
2	renal/urinary system phenotype	MP:0005367	9.7	INS
3	immune system phenotype	MP:0005387	9.3	MIF, IL6, PLAUR, TLR4
4	liver/biliary system phenotype	MP:0005370	8.5	INS, IL6, TLR2, TLR4
5	tumorigenesis	MP:0002006	8.0	CXCR3, TLR4, TLR2, IL6, IL1B, IL10
6	homeostasis/metabolism phenotype	MP:0005376	7.1	CXCR3, TLR4, TLR2, PLAUR, CRP, F5
7	cardiovascular system phenotype	MP:0005385	5.7	CRP, PLAUR, TLR2, TLR4, CXCR3, F5

Publications for genes affiliated with Melioidosis

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³⁵PubMed
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Articles related to melioidosis:

(show all 14)

id	Title	Authors	Year	Affiliating Genes
1	Expression and function of macrophage migration inhib itory factor (MIF) in melioidosis. (20169062)	Wiersinga W.J.... van der Poll T.	2010	MIF
2	Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis. (20142364)	Wiersinga W.J.... van der Poll T.	2010	PLAUR
3	Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis). (19114913)	Wiersinga W.J.... van der Poll T.	2009	IRAK3
4	Endogenous interleukin-18 improves the early antimicrobial host response in severe melioidosis. (17517876)	Wiersinga W.J.... van der Poll T.	2007	IL18
5	Successful treatment of life-threatening melioidosis with activated protein C and meropenem. (17332913)	Tan C.K.... Cheng K.C.	2007	F5
6	Expression profile and function of triggering receptor expressed on myeloid cells-1 during melioidosis. (18008257)	Wiersinga W.J.... van der Poll T.	2007	TREM1
7	A randomized controlled trial of granulocyte colony-stimulating factor for the treatment of severe sepsis due to melioidosis in Thailand. (17599307)	Cheng A.C.... Peacock S.J.	2007	CSF3
8	Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis). (17676990)	Wiersinga W.J.... van der Poll T.	2007	TLR1, TLR2, TLR4
9	Adjunctive granulocyte colony-stimulating factor for treatment of septic shock due to melioidosis. (14679445)	Cheng A.C.... Currie B.J.	2004	CSF3
10	C-reactive protein in the diagnosis of melioidosis. (15155996)	Cheng A.C.... Currie B.J.	2004	CRP
11	Diabetes mellitus, insulin, and melioidosis in Thailand. (12594658)	Simpson A.J.... White N.J.	2003	INS
12	The CXC chemokines gamma interferon (IFN-gamma)-inducible protein 10 and monokine induced by IFN-gamma are released during severe melioidosis. (10858199)	Lauw F.N.... van der Poll T.	2000	CXCR3, CXCL9
13	Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis. (10669346)	Simpson A.J.... Prins J.M.	2000	IL6, IL1B, IL10
14	Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis. (10558944)	Lauw F.N.... van der Poll T.	1999	IL18, IL15

Genes related to Melioidosis

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¹³GeneCards
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Genes related to melioidosis according to GeneCards:

(show all 23)

id	Symbol	Description	Score	GeneCards Section Context
1	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
2	TLR4	toll-like receptor 4	11.0	Publications
3	TLR2	toll-like receptor 2	11.0	Publications
4	LIPT2	lipoyl(octanoyl) transferase 2 (putative)	11.0
5	PAQR7	progestin and adipoQ receptor family member VII	11.0
6	TLR10	toll-like receptor 10	11.0	Publications
7	TREM1	triggering receptor expressed on myeloid cells 1	11.0	Publications
8	TLR1	toll-like receptor 1	11.0	Publications
9	IRAK3	interleukin-1 receptor-associated kinase 3	11.0	Publications
10	NCAPD3	non-SMC condensin II complex, subunit D3	11.0
11	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
12	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
13	FAM120B	family with sequence similarity 120B	11.0	Disorders
14	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
15	PLAUR	plasminogen activator, urokinase receptor	11.0	Publications
16	IL15	interleukin 15	11.0	Publications
17	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
18	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
19	IL1B	interleukin 1, beta	11.0	Publications
20	CRP	C-reactive protein, pentraxin-related	11.0	Publications
21	IL10	interleukin 10	11.0	Publications
22	INS	insulin	11.0	Publications
23	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Expression for genes affiliated with Melioidosis

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Melioidosis

Pathways for genes affiliated with Melioidosis

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⁴¹Thomson Reuters, ³⁶QIAGEN, ¹⁰EMD Millipore, ³Cell Signaling Technology, ³⁷R&D Systems, ²⁰KEGG
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Pathways related to melioidosis according to GeneDecks:

(show top 50) (show all 65)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways⁴¹	10.4	TLR1, TLR2
2	NFAT Signaling and Lymphocyte Interactions³⁶	10.3	IL15
3	Immune response_Bacterial infections in normal airways⁴¹	10.2	IL1B, TLR1
4	RAR-Gamma-RXR-Alpha Degradation³⁶	10.0	CSF3, CXCL9, IL15
5	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response¹⁰	9.9	TLR1, IL6, IRAK3
6	Toll-Like Receptors Pathway³⁶	9.8	TLR4, TLR2, TLR10, TLR1, IRAK3
7	PGC1Alpha Pathway³⁶	9.7	IL1B, IL18, IL15
8	Immune response_TLR signaling pathways⁴¹	9.5	TLR4, TLR2, TLR1, IL6, IRAK3
9	Molecular Mechanisms of Cancer³⁶	9.5	IL15, IL6, CXCL9
10	NF-kappaB Signaling³	9.5	TLR4, TLR2, TLR1, IL1B, IRAK3
11	MSP-RON Signaling³⁶	9.5	TLR4, TLR2, IL1B, IL18
12	TRAF Pathway³⁶	9.4	TLR4, TLR2, TLR10, TLR1, IL1B, IRAK3
13	Inflammasome Activation Pathways³⁷	9.4	TLR4, TLR2, TLR10, TLR1, IL1B, IL18
14	TREM1 Pathway³⁶	9.2	TLR4, TLR2, TLR10, TLR1, TREM1, IL1B
15	Immune response_MIF in innate immunity response⁴¹	9.2	TLR4, IL6, IL1B, MIF
16	Th1 Differentiation³⁷	9.2	TLR4, TLR2, TLR10, TLR1, IL18, IL10
17	Immune response MIF in innate immunity response¹⁰	9.2	TLR4, IL6, IL1B, MIF
18	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types³⁷	9.2	TLR4, TLR2, TLR10, TLR1, IL6, IL1B
19	Th17 Differentiation³⁷	9.2	TLR4, TLR2, TLR10, TLR1, IL6, IL1B
20	Toll-like receptor signaling pathway²⁰	9.1	CXCL9, TLR4, TLR2, TLR1, IL6, IL1B
21	Colorectal Cancer Metastasis³⁶	9.1	TLR4, TLR2, TLR10, TLR1, IL6
22	IL-10 Pathway³⁶	9.0	IL10, IL1B, IL6, TLR4
23	Rheumatoid arthritis²⁰	8.9	TLR4, TLR2, IL6, IL1B, IL18, IL15
24	NF-KappaB (p50-p65) Pathway³⁶	8.9	TLR4, TLR2, TLR10, TLR1, IL6, IL1B
25	NF-KappaB Family Pathway³⁶	8.9	TLR4, TLR2, TLR10, TLR1, IL6, IL1B
26	Toll-Like Receptor Signaling Pathways³⁷	8.9	TLR4, TLR2, TLR10, TLR1, IL6, IL1B
27	African trypanosomiasis²⁰	8.8	IL6, IL1B, IL18, IL10
28	Chagas disease (American trypanosomiasis)²⁰	8.8	IL10, IL1B, IL6, TLR2, TLR4
29	Amoebiasis²⁰	8.7	TLR4, TLR2, IL6, IL1B, IL10
30	Cytokine Network³⁶	8.6	IL6, IL1B, IL18, IL15, IL10
31	Akt Signaling³⁶	8.6	CXCR3, CXCL9, IL6, IL18, IL15, IL10
32	Tuberculosis²⁰	8.4	TLR4, TLR2, TLR1, IL6, IL1B, IL18
33	Endothelin-1 Signaling Pathway³⁶	8.4	CSF3, CXCL9, IL6, IL1B, IL18, IL10
34	Malaria²⁰	8.3	CSF3, TLR4, TLR2, IL6, IL1B, IL18
35	Selected targets of GCR-alpha¹⁰	8.2	TLR2, IL6, IL1B, INS
36	all-trans-Retinoic Acid Signaling in Brain³⁶	8.1	CSF3, CXCL9, IL6, IL1B, IL18, IL15
37	PEDF Induced Signaling³⁶	8.1	CSF3, CXCL9, IL6, IL1B, IL18, IL15
38	IL-6 Pathway³⁶	8.1	CSF3, CXCL9, IL6, IL1B, IL18, IL15
39	ERK Signaling³⁶	8.0	IL10, IL18, IL1B, IL6, CXCL9, CSF3
40	PAK Pathway³⁶	8.0	CSF3, CXCL9, IL6, IL1B, IL18, IL15
41	STAT3 Pathway³⁶	7.9	CSF3, CXCR3, CXCL9, IL6, IL1B, IL18
42	Cytokine-cytokine receptor interaction²⁰	7.9	CSF3, CXCR3, CXCL9, IL6, IL1B, IL18
43	Antioxidant Action of Vitamin-C³⁶	7.8	CSF3, CXCR3, CXCL9, IL6, IL1B, IL18
44	SOCS Pathway³⁶	7.7	IL6, IL1B, IL18, IL15, IL10, INS
45	MIF Mediated Glucocorticoid Regulation³⁶	7.7	MIF, CSF3, CXCL9, TLR4, IL6, IL1B
46	Regulation of eIF4 and p70S6K³⁶	7.7	IL6, IL1B, IL18, IL15, IL10, INS
47	MIF Regulation of Innate Immune Cells³⁶	7.7	CSF3, CXCL9, TLR4, IL6, IL1B, IL18
48	Rho Family GTPases³⁶	7.7	CSF3, CXCL9, IL6, IL1B, IL18, IL15
49	Tec Kinases Signaling³⁶	7.6	CXCR3, TLR4, TLR2, TLR10, TLR1, IL6
50	p38 Signaling³⁶	7.6	CSF3, CXCR3, CXCL9, IL6, IL1B, IL18

Compounds for genes affiliated with Melioidosis

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Sources:
³²Novoseek , ³⁴PharmGKB, ⁹DrugBank, ⁴²Tocris Bioscience, ¹⁸HMDB
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Compounds related to melioidosis according to GeneDecks:

(show top 50) (show all 131)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide³² ³⁴ ⁹ ⁹	13.7	CXCL9
2	pge2³²	10.2	TLR2, PLAUR, TLR4
3	calcitriol³² ⁴² ⁹ ¹⁸ ⁹	13.9	PLAUR, TLR2
4	sb 203580³² ⁴²	10.5	PLAUR, CRP, IL6
5	hbd2³²	9.4	TLR4, TLR2, IL6, IL1B
6	flagellin³²	9.3	TLR2, TLR4, CXCR3, TLR1, IL18, IL1B
7	tuberculin³²	9.2	MIF, IL10, IL15, IL18
8	rituximab³² ³⁴ ⁹ ⁹	12.2	IL10, IL15, CRP
9	turpentine³²	9.1	CRP, IL1B, IL6
10	groalpha³²	9.1	CXCR3, CXCL9, IL1B, IL18, IL10
11	anakinra³² ⁹ ⁹	11.0	CRP, IL6, IL1B, IL18
12	imiquimod³² ⁴² ⁹ ⁹	12.0	IL10, TLR4, IL6, IL18
13	poly(i-c)³²	8.9	IL6, TLR4, TLR2, IL15, IL18, IL1B
14	polymyxin b³²	8.9	TLR4, TLR2, IL6, IL1B, IL10
15	ifn-alpha³²	8.8	CXCL9, IL18, IL10, IL6, TLR4, CXCR3
16	gabexate mesilate³²	8.7	IL6, CRP, F5, IL10
17	il-12³²	8.6	IL10, IL1B, IL18, IL15, IL6
18	vegf³²	8.6	MIF, IL1B, F5, CRP, CSF3, PLAUR
19	cdp571³²	8.5	IL6, IL10, CRP
20	okt3³²	8.5	IL15, IL10, CRP, IL6
21	lipoteichoic acid³²	8.4	IL10, IL1B, IL18, IL6, TLR4, TLR2
22	peptidoglycan³²	8.4	IL1B, IL10, IL15, TLR2, IL6, TLR1
23	curcumin³²	8.3	IL18, IL1B, IL15, MIF, IL6, PLAUR
24	polyinosinic-polycytidylic acid³²	8.3	IL1B, IL18, IL15, IL10, IL6, TLR2
25	gm-csf³²	8.3	CSF3, IL6, IL1B, IL18, IL15, IL10
26	atorvastatin³² ³⁴ ⁹ ¹⁸ ⁹	12.2	IL18, F5, TLR4, IL10, CRP, IL6
27	simvastatin³² ³⁴ ⁴² ⁹ ¹⁸ ⁹	13.1	IL10, TLR4, TLR2, CRP, F5, IL6
28	tgf beta1³²	8.1	TLR4, PLAUR, IL6, IL15, IL1B, IL18
29	neopterin³²	8.1	PLAUR, CRP, IL6, IL10, IL18, IL1B
30	endotoxin³²	8.1	IRAK3, CXCL9, CXCR3, CSF3, CRP, F5
31	ly294002³²	7.9	CXCR3, IL10, TLR4, CRP, IL6, IL1B
32	il 10³²	7.9	CXCL9, IL10, IL15, CXCR3, IL18, IL6
33	etanercept³² ⁹ ⁹	9.9	IL1B, CXCR3, IL6, IL18, IL15, CRP
34	histamine³² ¹⁸	8.8	IL1B, TLR4, TLR2, IL18, IL15, IL10
35	tacrolimus³² ³⁴ ⁹ ⁹	10.8	F5, TLR4, CXCR3, TLR2, IL10, IL15
36	infliximab³² ⁹ ⁹	9.7	CXCR3, IL1B, IL15, IL6, CRP, TLR4
37	methotrexate³² ³⁴ ⁴² ⁹ ⁹	11.6	CSF3, IL10, IL6, IL15, IL18, IL1B
38	fibrinogen³²	7.6	PLAUR, CRP, TLR4, F5, IL6, TLR2
39	ccl3³²	7.5	IL1B, IL18, IL15, IL10, IL6, TLR2
40	thymidine³² ¹⁸	8.3	CXCR3, IL15, IL1B, IL6, IL18, IL10
41	retinoic acid³² ⁴² ¹⁸	9.3	MIF, CSF3, TLR4, TLR2, PLAUR, F5
42	rantes³²	7.3	IL1B, IL18, IL15, IL10, MIF, CSF3
43	hydrocortisone³² ⁹ ⁹	9.2	IL1B, CXCR3, MIF, F5, IL6, IL15
44	cholesterol³² ⁹ ¹⁸ ⁹	10.2	TLR4, PLAUR, TLR2, CRP, IL18, IL6
45	cycloheximide³²	7.0	CSF3, TLR2, IL15, TLR4, PLAUR, CRP
46	creatinine³²	6.9	F5, IL18, IL15, IL6, CRP, PLAUR
47	alanine³²	6.9	TLR4, TLR2, PLAUR, F5, IL6, IL18
48	nitric oxide³² ⁹ ¹⁸ ⁹	9.9	IL6, TLR2, TLR4, CXCL9, CXCR3, MIF
49	tyrosine³²	6.5	IL18, IL6, TREM1, PLAUR, TLR4, TLR2
50	dexamethasone³² ⁴² ³⁴ ⁹ ⁹	10.1	IL15, IL18, IL1B, IL10, CSF3, INS

GO Terms for genes affiliated with Melioidosis

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¹²Gene Ontology
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Cellular components related to melioidosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Toll-like receptor 1-Toll-like receptor 2 protein complex	GO:035354	9.8	TLR2, TLR1
2	external side of plasma membrane	GO:009897	9.7	TLR2, TLR4, CXCL9, CXCR3
3	extracellular region	GO:005576	6.0	TREM1, CRP, PLAUR, CXCL9, F5, IL6
4	extracellular space	GO:005615	5.7	MIF, CSF3, CXCL9, CRP, F5, IL6

Biological processes related to melioidosis according to GeneDecks:

(show all 42)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to triacyl bacterial lipopeptide	GO:071727	10.4	TLR2, TLR1
2	detection of triacyl bacterial lipopeptide	GO:042495	10.4	TLR2, TLR1
3	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response	GO:052033	10.4	TLR4, TLR1
4	microglial cell activation involved in immune response	GO:002282	10.4	TLR1, TLR4
5	positive regulation of macrophage cytokine production	GO:060907	10.4	TLR4, TLR2
6	positive regulation of tumor necrosis factor biosynthetic process	GO:042535	10.3	TLR1, TLR2, TLR4
7	cellular response to lipoteichoic acid	GO:071223	10.2	TLR4, TLR2
8	positive regulation of tumor necrosis factor production	GO:032760	10.2	TLR4, TLR2, IL18
9	macrophage activation	GO:042116	10.1	TLR4, TLR1
10	MyD88-dependent toll-like receptor signaling pathway	GO:002755	10.1	TLR4, TLR2, TLR10, IRAK3
11	positive regulation of tissue remodeling	GO:034105	10.1	IL18, IL15
12	positive regulation of NF-kappaB import into nucleus	GO:042346	10.0	IL1B, TLR2, TLR4
13	response to peptidoglycan	GO:032494	10.0	IL6, IRAK3
14	positive regulation of natural killer cell proliferation	GO:032819	10.0	IL18, IL15
15	positive regulation of granulocyte macrophage colony-stimulating factor production	GO:032725	9.9	IL1B, IL18
16	positive regulation of interferon-gamma production	GO:032729	9.9	IL18, IL1B, TLR4
17	positive regulation of inflammatory response	GO:050729	9.9	TLR4, TLR2, IL18, IL15
18	type 2 immune response	GO:042092	9.9	IL18, IL10
19	positive regulation of interleukin-6 biosynthetic process	GO:045410	9.9	TLR1, IL1B
20	negative regulation of interleukin-12 production	GO:032695	9.8	TLR2, IL10, IRAK3
21	negative regulation of interleukin-6 production	GO:032715	9.8	TLR4, IL10, IRAK3
22	negative regulation of interleukin-17 production	GO:032700	9.8	TLR4, TLR2
23	negative regulation of tumor necrosis factor production	GO:032720	9.8	IRAK3, IL10, TLR4
24	cellular response to mechanical stimulus	GO:071260	9.8	TLR4, IL1B, IL18
25	positive regulation of interleukin-8 production	GO:032757	9.8	IL18, IL1B, TLR2, TLR4
26	lipopolysaccharide-mediated signaling pathway	GO:031663	9.8	IL18, IL1B, TLR2, TLR4
27	positive regulation of chemokine production	GO:032722	9.7	TLR4, TLR2, IL6, IL18
28	innate immune response	GO:045087	9.7	TLR4, TLR2, TLR10, TLR1, MIF
29	positive regulation of MHC class II biosynthetic process	GO:045348	9.6	TLR4, IL10
30	negative regulation of lipid storage	GO:010888	9.6	CRP, IL6
31	positive regulation of interleukin-6 production	GO:032755	9.6	IL1B, IL6, TLR2, TLR4
32	positive regulation of T cell proliferation	GO:042102	9.5	IL6, IL1B, IL15
33	response to hypoxia	GO:001666	9.3	IL18, IL1B, CRP, TLR4
34	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	TLR4, TLR2, IL1B, INS
35	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.1	MIF, INS, IL6, TLR4
36	positive regulation of cytokine secretion	GO:050715	9.0	TLR2, IL10, INS, MIF
37	acute-phase response	GO:006953	8.9	INS, IL6, CRP
38	immune response	GO:006955	8.9	CSF3, CXCL9, TLR4, TLR2, TLR10, TLR1
39	MAPK cascade	GO:000165	8.9	INS, IL18, IL1B
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.5	TLR4, TLR2, IL6, IL1B, INS, IRAK3
41	cell-cell signaling	GO:007267	8.2	INS, IL10, IL15, IL18, IL1B, CXCL9
42	inflammatory response	GO:006954	7.1	MIF, CXCL9, TLR2, TLR10, TLR1, CRP

Molecular functions related to melioidosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	lipopolysaccharide receptor activity	GO:001875	9.8	TLR4, TLR2
2	transmembrane signaling receptor activity	GO:004888	9.7	TLR1, TLR10, TLR2, TLR4
3	Gram-positive bacterial cell surface binding	GO:051637	9.7	TLR2, CRP
4	receptor activity	GO:004872	9.4	TLR4, TLR2, TLR1, PLAUR, TREM1
5	growth factor activity	GO:008083	8.5	IL10, IL1B, IL6, CSF3
6	cytokine activity	GO:005125	7.5	MIF, CSF3, CXCL9, IL6, IL1B, IL18