MCID: MLD001
MIFTS: 65

Melioidosis

Categories: Genetic diseases, Rare diseases, Infectious diseases

Aliases & Classifications for Melioidosis

MalaCards integrated aliases for Melioidosis:

Name: Melioidosis 54 12 50 56 52 3 42 14 69
Nightcliff Gardener's Disease 12 50
Whitmore's Disease 12 3
Burkholderia Pseudomallei Infection 50
Acute and Fulminating Melioidosis 12
Subacute and Chronic Melioidosis 12
Melioidosis, Susceptibility to 29
B Pseudomallei Infection 50
Epizootic Lymphangitis 69
Whitmore Disease 50
Pseudoglanders 12

Characteristics:

Orphanet epidemiological data:

56
melioidosis
Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

OMIM 54 615557
Disease Ontology 12 DOID:5052
ICD9CM 35 025
MeSH 42 D008554
Orphanet 56 ORPHA31202
MESH via Orphanet 43 D008554
UMLS via Orphanet 70 C0025229
ICD10 via Orphanet 34 A24.1 A24.2 A24.3 more
UMLS 69 C0025229

Summaries for Melioidosis

NIH Rare Diseases : 50 melioidosis is an infectious disease caused by the bacteriaburkholderia pseudomallei that are commonly found in the soil and water. melioidosis is a rare disease in the united states, but it is common in tropical or subtropical areas of the world, including southeast asia, africa, and australia. the signs and symptoms of the disease can vary greatly and may mimic those of tuberculosis or common forms of pneumonia. signs and symptoms may include pain or swelling, fever, abscess, cough, high fever, headache, trouble breathing, and more. although healthy people can also experience signs and symptoms of the disease, people with certain conditions like diabetes, liver disease, kidney disease, lung disease, thalassemia, cancer, or certain autoimmune diseases are more severely affected. diagnosis is made by collecting blood, sputum, urine, or pus samples and growing the bacteria. current treatment is divided into two stages: an intravenous (iv) antibiotic stage and oral antibiotic maintenance stage to prevent recurrence. last updated: 1/13/2016

MalaCards based summary : Melioidosis, also known as nightcliff gardener's disease, is related to cutaneous leishmaniasis and myelitis. An important gene associated with Melioidosis is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotypes are Decreased viability in esophageal squamous lineage and hematopoietic system

CDC : 3 Melioidosis, also called Whitmore's disease, is an infectious disease that can infect humans or animals. The disease is caused by the bacterium Burkholderia pseudomallei.

OMIM : 54
Melioidosis is infection caused by the gram-negative, flagellated soil saprophyte Burkholderia pseudomallei, which is endemic in parts of southeast Asia and northern Australia. Sepsis is a common clinical presentation of disease, and lung is the organ most commonly involved. In northern Thailand, where B. pseudomallei is the most common bloodstream isolate, the overall melioidosis mortality rate exceeds 40%, and pneumonia confers more than 2-fold increased risk of death (summary by West et al., 2013). (615557)

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection, has material basis in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.

Wikipedia : 72 Melioidosis is an infectious disease caused by a Gram-negative bacterium, Burkholderia pseudomallei,... more...

Related Diseases for Melioidosis

Diseases related to Melioidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 301)
id Related Disease Score Top Affiliating Genes
1 cutaneous leishmaniasis 29.8 IL6 TNF
2 myelitis 29.5 IFNG IL10 IL6
3 pasteurellosis 29.5 IFNG IL6 TNF
4 pulmonary embolism 28.5 IFNG IL10 IL6 TLR2 TNF
5 systemic lupus erythematosus 28.1 IFNG IL10 IL18 IL6 TLR5 TNF
6 bulbospinal polio 10.8 IFNG TLR4
7 eye accommodation disease 10.7 IFNG IL10
8 oculo-cerebral dysplasia 10.7 TLR1 TLR5
9 prothrombin thrombophilia 10.7 TLR2 TLR4
10 glanders 10.7
11 graft-versus-host disease, protection against 10.6 IFNG IL10
12 thelaziasis 10.6 IFNG IL10
13 congenital insensitivity to pain with hyperhidrosis 10.6 IL10 TLR4
14 sternal cleft 10.6 IFNG TNF
15 autoimmune polyglandular syndrome type 3 10.6 IFNG TNF
16 dumping syndrome 10.6 IFNG IL10
17 pure autonomic failure 10.6 IL10 TNF
18 acute ackee fruit intoxication 10.6 IL10 TNF
19 spondylocostal dysostosis 4 10.6 TLR4 TNF
20 tabatznik syndrome 10.6 IL18 TNF
21 mosaic trisomy 1 10.6 IFNG TNF
22 low compliance bladder 10.6 TLR4 TNF
23 primary systemic mycosis 10.6 IFNG TNF
24 facial paralysis 10.6 IL10 IL18
25 multiple familial trichoepithelioma 10.5 IL10 TNF
26 basidiobolomycosis 10.5 IL10 TNF
27 lagophthalmos 10.5 IL10 TNF
28 type 1 papillary adenoma of the kidney 10.5 IL10 TNF
29 ethmoid sinus cancer 10.5 IFNG TLR4
30 hypertensive heart disease 10.5 TLR2 TLR4 TLR5
31 isolated growth hormone deficiency 10.5 IFNG IL18 TLR4
32 endosalpingiosis 10.5 IL10 TNF
33 hereditary choroidal atrophy 10.5 IFNG TLR2 TLR4
34 crustacean allergy 10.5 IL10 IL18
35 fanconi syndrome 10.5 TLR2 TLR4
36 idiopathic dilatation of the pulmonary artery 10.4 IL10 TNF
37 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.4 IFNG IL10
38 peroneal nerve paralysis 10.4 IL10 IL6
39 compensatory emphysema 10.4 TLR1 TLR2 TLR4
40 smarca4-deficient sarcoma of thorax 10.4 IL6 TNF
41 drug rash with eosinophilia and systemic symptoms 10.4 IL10 IL6
42 neutrophil-specific granule deficiency 10.4 IL10 TLR1 TLR2
43 askin's tumor 10.4 IFNG IL10 TLR2
44 steatorrhea 10.4 IFNG IL18 TNF
45 plantar wart 10.4 IFNG IL10 TNF
46 oropharyngeal cancer, childhood 10.4 IFNG IL10 TNF
47 aortic arch interruption 10.4 IL6 TNF
48 spindle cell hemangioma 10.4 IFNG IL10 TNF
49 tularemia 10.4 IFNG IL10 TNF
50 senile reticular retinal degeneration 10.4 IFNG IL10 TNF

Graphical network of the top 20 diseases related to Melioidosis:



Diseases related to Melioidosis

Symptoms & Phenotypes for Melioidosis

Clinical features from OMIM:

615557

GenomeRNAi Phenotypes related to Melioidosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.23 TLR4 TLR5 HABP2 IL18 IL6 IRAK3

MGI Mouse Phenotypes related to Melioidosis:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.2 TLR2 TLR4 TLR5 TNF IFNG IL10
2 immune system MP:0005387 10.18 HABP2 IFNG IL10 IL18 IL6 IRAK3
3 cardiovascular system MP:0005385 10.13 IFNG IL10 IL18 IL6 TLR2 TLR4
4 growth/size/body region MP:0005378 10.13 IFNG IL10 IL18 IL6 IRAK3 TLR2
5 homeostasis/metabolism MP:0005376 10.13 HABP2 IFNG IL10 IL18 IL6 IRAK3
6 digestive/alimentary MP:0005381 10.11 IFNG IL10 IL18 IL6 TLR2 TLR4
7 endocrine/exocrine gland MP:0005379 10.04 IFNG IL10 IL6 IRAK3 TLR2 TLR5
8 adipose tissue MP:0005375 10.01 TLR4 TLR5 TNF IL18 IL6 TLR2
9 liver/biliary system MP:0005370 9.92 HABP2 IFNG IL10 IL6 TLR2 TLR4
10 integument MP:0010771 9.91 IFNG IL10 IL18 IL6 TLR2 TLR4
11 muscle MP:0005369 9.8 IL18 IL6 TLR2 TLR4 TNF IFNG
12 neoplasm MP:0002006 9.63 IFNG IL10 IL6 TLR2 TLR4 TNF
13 respiratory system MP:0005388 9.5 IFNG IL10 IL6 TLR2 TLR4 TLR5
14 skeleton MP:0005390 9.17 TLR4 TNF IFNG IL10 IL6 IRAK3

Drugs & Therapeutics for Melioidosis

Drugs for Melioidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 4 723-46-6 5329
2
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
3 Anti-Bacterial Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Antimalarials Phase 4
6 Antiparasitic Agents Phase 4
7 Antiprotozoal Agents Phase 4
8 Renal Agents Phase 4
9 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
10
Ceftazidime Approved 78439-06-2, 72558-82-8 5481173
11
Meropenem Approved, Investigational 119478-56-7 64778 441130
12 Pharmaceutical Solutions
13 Thienamycins
14 Antibodies
15 Immunoglobulins

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Co-trimoxazole as Maintenance Therapy for Meliodosis Recruiting NCT01420341 Phase 4 Co-trimoxazole 12;Co-trimoxazole 20
2 A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis Unknown status NCT00579956 Meropenem;Ceftazidime
3 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
4 A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand Recruiting NCT02089152
5 Clinical Presentation of Melioidosis in Head and Neck Region Recruiting NCT03048513
6 Study to Obtain Blood and Voided Urine Samples to Improve the Diagnosis of Melioidosis Recruiting NCT02668406

Search NIH Clinical Center for Melioidosis

Cochrane evidence based reviews: melioidosis

Genetic Tests for Melioidosis

Genetic tests related to Melioidosis:

id Genetic test Affiliating Genes
1 Melioidosis, Susceptibility to 29

Anatomical Context for Melioidosis

MalaCards organs/tissues related to Melioidosis:

39
Lung, Liver, Bone, Kidney, Skin, Testes, T Cells

Publications for Melioidosis

Articles related to Melioidosis:

(show top 50) (show all 665)
id Title Authors Year
1
Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis. ( 28939855 )
2017
2
Anion inhibition profiles of the I^-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei responsible of melioidosis and highly drug resistant to common antibiotics. ( 27914949 )
2017
3
Glanders And Melioidosis ( 28846298 )
2017
4
Accidental Occupational Exposure to Burkholderia pseudomallei in South Korea Did Not Result in Melioidosis. ( 28414016 )
2017
5
Sulfonamide inhibition profile of the I^-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis. ( 28025002 )
2017
6
Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis. ( 28296884 )
2017
7
Central nervous system melioidosis in the pediatric age group: review. ( 28451778 )
2017
8
Imported Case of Melioidosis in Oman: Case Report. ( 28042405 )
2017
9
Molecular detection of leptospirosis and melioidosis co-infection: A case report. ( 28330585 )
2017
10
Melioidosis with possible Haemophagocytic lymphohistiocytosis. ( 28571052 )
2017
11
Host gene expression analysis in Sri Lankan melioidosis patients. ( 28628607 )
2017
12
A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-I+ levels in human melioidosis. ( 28475641 )
2017
13
Gastrointestinal manifestations of melioidosis: A single center experience. ( 28353081 )
2017
14
Gastrointestinal tract involvement in melioidosis. ( 28673019 )
2017
15
Non-healing chest wall ulcer caused by cutaneous melioidosis. ( 28232013 )
2017
16
Melioidosis in lower provincial Cambodia: A case series from a prospective study of sepsis in Takeo Province. ( 28902844 )
2017
17
Cavitary lung lesions: Melioidosis and pulmonary embolism causing necrotizing pneumonia. ( 28791214 )
2017
18
A simple laboratory algorithm for diagnosis of melioidosis in resource-constrained areas: a study from north-central Vietnam. ( 28780059 )
2017
19
A case-control study of community-acquired Acinetobacter baumannii pneumonia and melioidosis pneumonia in northeast Thailand: an emerging fatal disease with unique clinical features. ( 27789057 )
2017
20
The gut microbiota as a modulator of innate immunity during melioidosis. ( 28422970 )
2017
21
Comparison of O-polysaccharide and hemolysin co-regulated protein as target antigens for serodiagnosis of melioidosis. ( 28358816 )
2017
22
Acute bacteremic pneumonia due to melioidosis developing in the intensive care setting. ( 28417070 )
2017
23
Melioidosis with Portal Vein Thrombosis. ( 28473933 )
2017
24
DNA vaccination resurfaces in the struggle against melioidosis. ( 28481716 )
2017
25
Type III Secretion in the Melioidosis Pathogen Burkholderia pseudomallei. ( 28664152 )
2017
26
Pediatric melioidosis in Sarawak, Malaysia: Epidemiological, clinical and microbiological characteristics. ( 28599008 )
2017
27
The epidemiology and clinical features of melioidosis in Far North Queensland: Implications for patient management. ( 28264029 )
2017
28
Hydrological connectivity and Burkholderia pseudomallei prevalence in wetland environments: investigating rice-farming community's risk of exposure to melioidosis in North-East Thailand. ( 28536911 )
2017
29
Melioidosis mimicking tubercular cold abscess. ( 28928256 )
2017
30
An avirulent Burkholderia pseudomallei a88purM strain with atypical type B LPS: expansion of the toolkit for biosafe studies of melioidosis. ( 28592242 )
2017
31
Functional characterisation of Burkholderia pseudomallei biotin protein ligase: A toolkit for anti-melioidosis drug development. ( 28454708 )
2017
32
Melioidosis: Clinical impact and public health threat in the tropics. ( 28493905 )
2017
33
A case report of co-infection of Melioidosis and cutaneous Leishmaniasis. ( 28764662 )
2017
34
Melioidosis: An Emerging Infection with Fatal Outcomes. ( 28701847 )
2017
35
Notes from the Field: Travel-Associated Melioidosis and Resulting Laboratory Exposures - United States, 2016. ( 28934180 )
2017
36
Calprotectin as a Biomarker for Melioidosis Disease Progression and Management. ( 28179407 )
2017
37
Are brucellosis, Q fever and melioidosis potential causes of febrile illness in Madagascar? ( 28502643 )
2017
38
Septicemic Melioidosis with Ruptured Splenic Abscess in a Patient with Thalassemia Intermedia. ( 28250624 )
2017
39
Endocarditis in melioidosis ( 28078837 )
2016
40
Characteristics, clinical outcomes and factors influencing mortality of patients with melioidosis in southern Thailand: A 10-year retrospective study. ( 26972397 )
2016
41
Protection against Experimental Melioidosis with a Synthetic manno-Heptopyranose Hexasaccharide Glycoconjugate. ( 27124182 )
2016
42
Burkholderia pseudomallei: First case of melioidosis in Portugal. ( 26962474 )
2016
43
Septicemic melioidosis in a transplant recipient causing graft dysfunction. ( 27795637 )
2016
44
What clinical factors are associated with mortality in septicemic melioidosis? A report from an endemic area. ( 27131004 )
2016
45
Eighth World Melioidosis Congress, 2016: presenting an emerging infectious disease in the context of a89One Healtha89. ( 27855480 )
2016
46
Melioidosis: Series of Eight Cases. ( 27735148 )
2016
47
Whole-genome sequencing of a quarter-century melioidosis outbreak in temperate Australia uncovers a region of low-prevalence endemicity. ( 28348862 )
2016
48
Investigation of Recurrent Melioidosis in Lao People's Democratic Republic by Multilocus Sequence Typing. ( 27001759 )
2016
49
Chronic melioidosis presenting with multiple abscesses. ( 27822380 )
2016
50
Osteomyelitis of Humerus and Intramuscular Abscess Due to Melioidosis. ( 28166079 )
2016

Variations for Melioidosis

Expression for Melioidosis

LifeMap Discovery
Genes differentially expressed in tissues of Melioidosis patients vs. healthy controls: 35 (show top 50) (show all 181)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CD177 CD177 molecule Blood + 8.41 0.000
2 ZDHHC19 zinc finger, DHHC-type containing 19 Blood + 6.91 0.000
3 MMP8 matrix metallopeptidase 8 Blood + 6.49 0.000
4 SLC51A solute carrier family 51, alpha subunit Blood + 6.46 0.000
5 HP haptoglobin Blood + 6.23 0.000
6 FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide Blood - 6.00 0.000
7 GPR84 G protein-coupled receptor 84 Blood + 5.86 0.000
8 ANKRD22 ankyrin repeat domain 22 Blood + 5.72 0.000
9 OLAH oleoyl-ACP hydrolase Blood + 5.54 0.000
10 LRRN3 leucine rich repeat neuronal 3 Blood - 5.51 0.000
11 PCOLCE2 procollagen C-endopeptidase enhancer 2 Blood + 5.47 0.000
12 C1QC complement component 1, q subcomponent, C chain Blood + 5.42 0.000
13 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Blood + 5.39 0.000
14 CCNA1 cyclin A1 Blood + 5.14 0.000
15 C1QB complement component 1, q subcomponent, B chain Blood + 5.09 0.000
16 LINC00668 long intergenic non-protein coding RNA 668 Blood + 4.99 0.000
17 CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Blood + 4.98 0.000
18 FGF13 fibroblast growth factor 13 Blood + 4.96 0.000
19 NOV nephroblastoma overexpressed Blood - 4.84 0.000
20 PLVAP plasmalemma vesicle associated protein Blood - 4.76 0.000
21 KL klotho Blood + 4.74 0.000
22 SLCO4A1 solute carrier organic anion transporter family, member 4A1 Blood + 4.73 0.000
23 MYO10 myosin X Blood + 4.68 0.000
24 SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 Blood + 4.68 0.000
25 RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 Blood - 4.67 0.000
26 RETN resistin Blood + 4.65 0.000
27 CD274 CD274 molecule Blood + 4.44 0.000
28 MCEMP1 mast cell-expressed membrane protein 1 Blood + 4.44 0.000
29 BMX BMX non-receptor tyrosine kinase Blood + 4.41 0.000
30 SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 Blood + 4.38 0.000
31 CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) Blood + 4.38 0.000
32 GRB10 growth factor receptor-bound protein 10 Blood + 4.37 0.000
33 CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 Blood - 4.25 0.000
34 LINC01220 long intergenic non-protein coding RNA 1220 Blood + 4.20 0.000
35 LTF lactotransferrin Blood + 4.19 0.000
36 SLC26A8 solute carrier family 26 (anion exchanger), member 8 Blood + 4.18 0.000
37 ARG1 arginase 1 Blood + 4.17 0.000
38 IL18R1 interleukin 18 receptor 1 Blood + 4.17 0.000
39 IL1R2 interleukin 1 receptor, type II Blood + 4.08 0.000
40 SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 Blood + 4.06 0.000
41 CFH complement factor H Blood + 4.03 0.000
42 G0S2 G0/G1 switch 2 Blood + 4.02 0.000
43 MMP9 matrix metallopeptidase 9 Blood + 3.97 0.000
44 FCAR Fc fragment of IgA receptor Blood + 3.94 0.000
45 SCN9A sodium channel, voltage gated, type IX alpha subunit Blood + 3.94 0.000
46 FAM20A family with sequence similarity 20, member A Blood + 3.94 0.000
47 KRTAP19-6 keratin associated protein 19-6 Blood + 3.93 0.000
48 TDRD9 tudor domain containing 9 Blood + 3.92 0.000
49 KREMEN1 kringle containing transmembrane protein 1 Blood + 3.86 0.000
50 HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Blood + 3.84 0.000
Search GEO for disease gene expression data for Melioidosis.

Pathways for Melioidosis

Pathways related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 IFNG IL10 IL18 IL6 IRAK3 LY96
2
Show member pathways
13.6 IFNG IL10 IL18 IL6 LY96 TLR4
3
Show member pathways
13.55 IRAK3 LY96 TLR1 TLR10 TLR2 TLR4
4
Show member pathways
13.42 IL10 IL18 IL6 IRAK3 TLR1 TLR10
5
Show member pathways
13.31 IFNG IL10 IL18 IL6 IRAK3 TNF
6
Show member pathways
13.26 IFNG IRAK3 TLR1 TLR10 TLR2 TLR4
7
Show member pathways
13.01 IL18 IL6 LY96 TLR1 TLR10 TLR2
8
Show member pathways
12.85 IFNG IL18 IL6 TLR2 TLR4 TNF
9
Show member pathways
12.77 IL6 IRAK3 TLR1 TLR10 TLR2 TLR4
10
Show member pathways
12.73 IFNG IL10 IL6 IRAK3 LY96 TLR1
11
Show member pathways
12.69 IRAK3 LY96 TLR1 TLR10 TLR2 TLR4
12 12.63 IFNG IL10 IRAK3 TLR1 TLR2 TNF
13
Show member pathways
12.62 IFNG IL10 IL18 IL6 TNF
14
Show member pathways
12.62 IFNG IL10 IL18 IL6 TLR2 TLR4
15
Show member pathways
12.59 IFNG IL10 IL18 TNF
16
Show member pathways
12.46 LY96 TLR1 TLR2 TLR4
17
Show member pathways
12.42 IFNG IL10 IL6 TNF
18
Show member pathways
12.4 IFNG IL6 TLR2 TLR5 TNF
19
Show member pathways
12.36 IFNG IL6 IRAK3 LY96 TLR4 TNF
20
Show member pathways
12.34 IFNG IL10 LY96 TLR2 TLR4 TNF
21
Show member pathways
12.25 IFNG IL10 IL18 IL6 TNF
22 12.22 IFNG IL10 IL18 IL6 TLR1 TLR2
23 12.18 TLR1 TLR10 TLR2 TLR4 TLR5
24 12.14 IFNG IL6 TLR1 TLR10 TLR2 TLR4
25
Show member pathways
12.13 TLR1 TLR10 TLR2 TLR4 TLR5
26 12.07 IFNG IL6 TLR4 TNF
27 12.05 IFNG IL10 IL6 TNF
28 12.04 IL10 IL18 IL6 TNF
29 11.97 IFNG IL10 IL6 TLR2 TLR4 TNF
30
Show member pathways
11.96 IFNG IL6 TLR1 TLR10 TLR2 TLR4
31 11.94 IFNG IL18 IL6 TLR4 TLR5
32 11.93 TLR1 TLR10 TLR2 TLR4 TLR5
33 11.93 IFNG IL18 IL6 TLR2 TLR4 TNF
34 11.89 IFNG IL6 TLR4
35 11.88 IFNG IL10 IL18 TNF
36 11.88 IL10 IL6 LY96 TLR4 TNF
37 11.87 LY96 TLR4 TNF
38
Show member pathways
11.86 IL6 LY96 TLR4
39 11.85 IFNG IL10 IL6
40 11.85 IFNG IL10 IL6 TNF
41 11.78 IL10 IL6 TLR2 TLR4 TLR5 TNF
42 11.74 LY96 TLR4 TNF
43 11.7 IRAK3 LY96 TLR4 TNF
44
Show member pathways
11.68 IFNG IL6 TNF
45
Show member pathways
11.68 IFNG IL10 IL18 IL6 TLR1 TLR10
46 11.65 IL10 IL18 IL6 TNF
47 11.65 IFNG IL18 TLR2 TLR4 TNF
48 11.65 IL18 IL6 TLR2 TLR4 TLR5 TNF
49 11.58 IFNG IL6 TNF
50 11.52 IFNG IL6 TNF

GO Terms for Melioidosis

Cellular components related to Melioidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 HABP2 IFNG IL10 IL18 IL6 LY96
2 external side of plasma membrane GO:0009897 9.56 IFNG IL6 TLR4 TNF
3 lipopolysaccharide receptor complex GO:0046696 9.16 LY96 TLR4
4 intrinsic component of plasma membrane GO:0031226 9.13 LY96 TLR2 TLR4
5 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 80)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.99 IFNG IL10 TLR1 TLR4 TLR5 TNF
2 positive regulation of gene expression GO:0010628 9.98 IFNG IL6 TLR2 TLR4 TNF
3 response to lipopolysaccharide GO:0032496 9.97 IL10 IL6 IRAK3 LY96 TLR2 TLR4
4 immune response GO:0006955 9.97 IFNG IL10 IL18 IL6 TLR1 TLR10
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 IL6 IRAK3 TLR2 TLR4 TNF
6 response to virus GO:0009615 9.92 IFNG IRAK3 TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.92 IL10 IL6 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.91 IL6 TLR2 TNF
9 positive regulation of protein kinase B signaling GO:0051897 9.91 IL18 IL6 TNF
10 apoptotic signaling pathway GO:0097190 9.89 LY96 TLR4 TNF
11 positive regulation of inflammatory response GO:0050729 9.89 IL18 TLR10 TLR2 TLR4
12 response to insulin GO:0032868 9.88 IL10 IL6 TLR2
13 response to glucocorticoid GO:0051384 9.88 IL10 IL6 TNF
14 positive regulation of tumor necrosis factor production GO:0032760 9.88 IFNG LY96 TLR2 TLR4
15 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.87 IFNG IL18 IL6
16 positive regulation of interleukin-6 production GO:0032755 9.87 IL6 TLR2 TLR4 TNF
17 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.86 LY96 TLR4 TNF
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 IL18 IL6 TNF
19 humoral immune response GO:0006959 9.85 IFNG IL6 TNF
20 positive regulation of interferon-gamma production GO:0032729 9.84 IL18 TLR4 TNF
21 negative regulation of tumor necrosis factor production GO:0032720 9.84 IL10 IRAK3 TLR4
22 positive regulation of interleukin-8 production GO:0032757 9.84 TLR2 TLR4 TLR5 TNF
23 negative regulation of interleukin-6 production GO:0032715 9.83 IL10 IRAK3 TLR4 TNF
24 toll-like receptor signaling pathway GO:0002224 9.83 LY96 TLR1 TLR10 TLR2 TLR4
25 positive regulation of interleukin-12 production GO:0032735 9.8 IFNG TLR2 TLR4
26 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 IFNG IL6 TLR4 TLR5 TNF
27 cellular response to lipopolysaccharide GO:0071222 9.8 IFNG IL10 IL6 LY96 TLR4 TLR5
28 defense response to protozoan GO:0042832 9.79 IFNG IL10 IL6
29 positive regulation of NF-kappaB import into nucleus GO:0042346 9.78 IL18 TLR2 TLR4 TNF
30 negative regulation of growth of symbiont in host GO:0044130 9.77 IFNG IL10 TNF
31 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 IL18 LY96 TLR2 TLR4 TNF
32 positive regulation of osteoclast differentiation GO:0045672 9.76 IFNG TNF
33 necroptotic process GO:0070266 9.76 LY96 TLR4
34 positive regulation of chemokine production GO:0032722 9.76 IL6 TLR2 TLR4 TNF
35 toll-like receptor 4 signaling pathway GO:0034142 9.75 LY96 TLR4
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.75 IFNG TNF
37 cell activation GO:0001775 9.75 TLR1 TLR2
38 cellular response to hepatocyte growth factor stimulus GO:0035729 9.75 IL10 IL6
39 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.74 TLR2 TLR4
40 response to molecule of bacterial origin GO:0002237 9.74 IL10 TLR2
41 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.74 LY96 TLR4
42 negative regulation of interleukin-12 production GO:0032695 9.74 IL10 IRAK3
43 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.74 IL10 TNF
44 I-kappaB phosphorylation GO:0007252 9.74 TLR2 TLR4
45 positive regulation of protein import into nucleus, translocation GO:0033160 9.74 IFNG IL6
46 T-helper 1 type immune response GO:0042088 9.73 IL18 TLR4
47 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.73 TLR1 TLR4
48 negative regulation of interleukin-17 production GO:0032700 9.73 IFNG TLR4
49 cellular response to lipoteichoic acid GO:0071223 9.73 TLR2 TLR4
50 positive regulation of MHC class II biosynthetic process GO:0045348 9.73 IFNG IL10 TLR4

Molecular functions related to Melioidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.46 TLR1 TLR10 TLR4 TLR5
2 cytokine activity GO:0005125 9.35 IFNG IL10 IL18 IL6 TNF
3 lipopeptide binding GO:0071723 9.26 TLR1 TLR2
4 lipopolysaccharide receptor activity GO:0001875 8.8 LY96 TLR2 TLR4

Sources for Melioidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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