MPGN
MCID: MMB001
MIFTS: 48

Membranoproliferative Glomerulonephritis (MPGN) malady

Rare diseases, Nephrological diseases categories
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Summaries for Membranoproliferative Glomerulonephritis

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Wikipedia:65 Membranoproliferative glomerulonephritis (\"MPGN\"), also known as mesangiocapillary glomerulonephritis,... more...

MalaCards based summary: Membranoproliferative Glomerulonephritis, also known as mesangiocapillary glomerulonephritis, is related to glomerulonephritis and dense deposit disease/membranoproliferative glomerulonephritis type ii. An important gene associated with Membranoproliferative Glomerulonephritis is CFHR5 (complement factor H-related 5), and among its related pathways are Staphylococcus aureus infection and Pertussis. The compounds fibrinogen and cardiolipin have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and b cells.

Aliases & Classifications for Membranoproliferative Glomerulonephritis

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Membranoproliferative Glomerulonephritis, Aliases & Descriptions:

Name: Membranoproliferative Glomerulonephritis 8 42 22 10
Mesangiocapillary Glomerulonephritis 42 62
Mpgn 42 62
Primary Membranoproliferative Glomerulonephritis 42
Membranoproliferative Glomerulonephritis Nos 8
 
Glomerulonephritis, Membranoproliferative 62
Glomerulonephritis Membranoproliferative 44
Chronic Glomerulonephritis, Lobular 8
Lobular Glomerulonephritis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:2920
MeSH34 D015432
SNOMED-CT57 80321008
NCIt39 C34644

Related Diseases for Membranoproliferative Glomerulonephritis

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Diseases related to Membranoproliferative Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis32.1TSLP, CFH, CFP
2dense deposit disease/membranoproliferative glomerulonephritis type ii30.9CFHR5, CFH
3atypical hemolytic-uremic syndrome30.7CFH
4acute poststreptococcal glomerulonephritis30.6CFP
5nephritis30.5C4A, CFP
6complement deficiency30.4C4A, CFP
7lupus erythematosus30.2C4A, CFP
8systemic lupus erythematosus29.9CFP, CFH, C4BPA, C4A
9hepatitis11.1
10hepatitis c11.0
11hepatitis c virus10.9
12cryoglobulinemia10.7
13dense deposit disease10.7
14hepatitis b10.6
15leukemia10.6
16nephrotic syndrome10.6
17complement factor h deficiency10.6
18castleman's disease10.5
19lipodystrophy10.5
20vasculitis10.5
21chronic lymphocytic leukemia10.4
22glomerulosclerosis10.4
23purpura10.4
24lupus nephritis10.4
25diabetes mellitus10.4
26focal segmental glomerulosclerosis10.4
27liver cirrhosis10.4
28takayasu's arteritis10.4
29crescentic glomerulonephritis10.4
30hemolytic-uremic syndrome10.4
31proliferative glomerulonephritis10.4
32retinitis10.4
33thyroiditis10.4
34cfhr5-related dense deposit disease / membranoproliferative glomerulonephritis type ii10.4
35nephrotic syndrome, type 710.4
36interstitial nephritis10.3
37arthritis10.3
38chronic myeloid leukemia10.3
39diabetic nephropathy10.3
40hypertension10.3
41mantle cell lymphoma10.3
42pulmonary sarcoidosis10.3
43rheumatoid arthritis10.3
44autoimmune thyroiditis10.3
45macroglobulinemia10.3
46strongyloidiasis10.3
47kaposi's sarcoma10.3
48agammaglobulinemia10.3
49myeloid leukemia10.3
50pneumonia10.3

Graphical network of the top 20 diseases related to Membranoproliferative Glomerulonephritis:



Diseases related to membranoproliferative glomerulonephritis

Symptoms for Membranoproliferative Glomerulonephritis

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Drugs & Therapeutics for Membranoproliferative Glomerulonephritis

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Drug clinical trials:

Search ClinicalTrials for Membranoproliferative Glomerulonephritis

Search NIH Clinical Center for Membranoproliferative Glomerulonephritis

Genetic Tests for Membranoproliferative Glomerulonephritis

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Genetic tests related to Membranoproliferative Glomerulonephritis:

id Genetic test Affiliating Genes
1 Membranoproliferative Glomerulonephritis22

Anatomical Context for Membranoproliferative Glomerulonephritis

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MalaCards organs/tissues related to Membranoproliferative Glomerulonephritis:

32
Kidney, Liver, B cells, Lymph node, Thyroid, Lung, Myeloid, Eye, Spleen, Smooth muscle, Colon, Ovary, Testes, Monocytes, T cells, Endothelial

Animal Models for Membranoproliferative Glomerulonephritis or affiliated genes

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Publications for Membranoproliferative Glomerulonephritis

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Articles related to Membranoproliferative Glomerulonephritis:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. (21982457)
2012
2
Pathologist's puzzle: Membranoproliferative glomerulonephritis-like features in cryoglobulinemic glomerulonephritis. (22381806)
2012
3
A case of idiopathic membranoproliferative glomerulonephritis with a transient glomerular deposition of nephritis-associated plasmin receptor antigen. (22183562)
2012
4
Cryoglobulinemic membranoproliferative glomerulonephritis: beyond conventional therapy. (21426893)
2011
5
Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis. (21810760)
2011
6
A case of idiopathic basal ganglia calcification associated with membranoproliferative glomerulonephritis. (22001464)
2011
7
Membranoproliferative glomerulonephritis type I in renal transplantation patients: a single-center study of a cohort of 68 renal transplants followed up for 11 years. (21502910)
2011
8
Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. (19528347)
2009
9
A case of autoimmune thyroiditis and membranoproliferative glomerulonephritis. (18008089)
2009
10
Membranoproliferative glomerulonephritis with essential cryoglobulinemia. (20142909)
2008
11
Remission of a B cell CLL-associated membranoproliferative glomerulonephritis Type I with rituximab and bendamustine. (18397703)
2008
12
Nocardial cerebral abscess associated with mycetoma, pneumonia, and membranoproliferative glomerulonephritis. (17428927)
2007
13
Terminal complement complexes in childhood type I membranoproliferative glomerulonephritis. (17173247)
2006
14
Treatment of idiopathic membranoproliferative glomerulonephritis with mycophenolate mofetil and steroids. (15479745)
2004
15
Histopathological atlas of renal diseases. Membranoproliferative glomerulonephritis. (15372408)
2004
16
IgA-associated glomerulonephritis with membranoproliferative glomerulonephritis-like pattern in two children. (14712358)
2003
17
Effects of angiotensin converting enzyme inhibitor on renal function in patients of membranoproliferative glomerulonephritis with mild to moderate renal insufficiency. (12568207)
2002
18
Membranoproliferative glomerulonephritis. (11568249)
2001
19
Response of hepatitis B induced membranoproliferative glomerulonephritis to HAART. (11463942)
2001
20
Decreasing hypocomplementemia and membranoproliferative glomerulonephritis in Japan. (10955929)
2000
21
Tubulointerstitial changes are less important in membranoproliferative glomerulonephritis than in IgA nephropathy. (11015015)
2000
22
Cutaneous telangiectasias, sparse hair, and type I membranoproliferative glomerulonephritis. (10228999)
1999
23
Differences in glomerular leukocyte infiltration between IgA nephropathy and membranoproliferative glomerulonephritis. (9550635)
1998
24
Recurrent type III membranoproliferative glomerulonephritis after kidney transplantation. (9133484)
1997
25
Subretinal fluid associated with membranoproliferative glomerulonephritis type 2. (9230841)
1997
26
Retinal function abnormalities in membranoproliferative glomerulonephritis type II. (9152067)
1997
27
Membranoproliferative glomerulonephritis, p-antineutrophil cytoplasmic antibodies, and rheumatoid arthritis. Report of a case. (8689286)
1996
28
Case for the panel. Unusual ultrastructural association between erythrocytes and glomerular endothelial cells in patients with membranoproliferative glomerulonephritis. (8727072)
1996
29
Intercellular adhesion molecule-1, intercellular adhesion molecule-3, and leukocyte integrins in leukocyte accumulation in membranoproliferative glomerulonephritis type I. (9158205)
1996
30
Expression of intercellular adhesion molecule-1 and vascular adhesion molecule-1 in kidney of patients with lupus nephritis and membranoproliferative glomerulonephritis]. (7544695)
1995
31
Occurrence of C3 nephritic factor and C4 nephritic factor in membranoproliferative glomerulonephritis (MPGN). (8306508)
1994
32
Membranoproliferative glomerulonephritis associated with hepatitis C virus infection. (7510533)
1993
33
DP polymorphism in HLA-A1,-B8,-DR3 extended haplotypes associated with membranoproliferative glomerulonephritis and systemic lupus erythematosus. (8100139)
1993
34
Activation of the alternative pathway of complement by monoclonal lambda light chains in membranoproliferative glomerulonephritis. (1532415)
1992
35
Methyldopa-induced colitis in a patient with membranoproliferative glomerulonephritis. (1504427)
1992
36
Membranoproliferative glomerulonephritis in dogs with a genetically determined deficiency of the third component of complement. (1864020)
1991
37
Fundus changes in chronic membranoproliferative glomerulonephritis type II. (2103524)
1990-1991
38
Patterns of complement activation in idiopathic membranoproliferative glomerulonephritis, types I, II, and III. (2205097)
1990
39
Long-term prognosis of membranoproliferative glomerulonephritis type I. Significance of clinical and morphological parameters: an investigation of 220 cases. (2370922)
1990
40
Long-term follow-up of membranoproliferative glomerulonephritis type II and pregnancy: a case report. (2758699)
1989
41
Regression of recurrent membranoproliferative glomerulonephritis type II in a transplanted kidney after plasmapheresis therapy. (2964750)
1988
42
Differences between membranoproliferative glomerulonephritis types I and III in clinical presentation, glomerular morphology, and complement perturbation. (3826060)
1987
43
Clinico-pathological study of atypical membranoproliferative glomerulonephritis. (3613256)
1987
44
C5 measurement in membranoproliferative glomerulonephritis patients with C3 nephritic factor. (3600936)
1987
45
Tubulo-interstitial alterations in type I membranoproliferative glomerulonephritis. An investigation of 259 cases. (3588405)
1987
46
Major-histocompatibility-complex extended haplotypes in membranoproliferative glomerulonephritis. (3458025)
1986
47
Results of a controlled drug trial in membranoproliferative glomerulonephritis. (3886998)
1985
48
Membranoproliferative glomerulonephritis in a tropical environment. (6625727)
1983
49
Buckley's syndrome and membranoproliferative glomerulonephritis. (7121674)
1982
50
Chronic lymphocytic leukemia and membranoproliferative glomerulonephritis. (6816695)
1982

Variations for Membranoproliferative Glomerulonephritis

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Expression for genes affiliated with Membranoproliferative Glomerulonephritis

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Expression patterns in normal tissues for genes affiliated with Membranoproliferative Glomerulonephritis

Search GEO for disease gene expression data for Membranoproliferative Glomerulonephritis.

Pathways for genes affiliated with Membranoproliferative Glomerulonephritis

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Pathways related to Membranoproliferative Glomerulonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2C4A, CFH
29.1C4A, C4BPA
3
Show member pathways
8.7CFH, C4BPA, C4A
4
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.7C4A, C4BPA, CFH
5
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
8.1C4A, C4BPA, CFH, CFP

Compounds for genes affiliated with Membranoproliferative Glomerulonephritis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB
See all sources

Compounds related to Membranoproliferative Glomerulonephritis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1fibrinogen449.5C4BPA, CFH
2cardiolipin44 1110.4CFH, C4BPA
3polysaccharide449.1CFH, CFP
4anaphylatoxin449.0C4A, CFP
5heparin44 28 24 1111.5C4BPA, CFHR5, CFH, CFP

GO Terms for genes affiliated with Membranoproliferative Glomerulonephritis

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Cellular components related to Membranoproliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9TSLP, CFH, CFP
2blood microparticleGO:0725628.4CFH, C4BPA, C4A
3extracellular regionGO:0055767.5C4A, C4BPA, CFHR5, CFH, CFP

Biological processes related to Membranoproliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement activation, classical pathwayGO:0069589.1C4A, C4BPA
2complement activation, alternative pathwayGO:0069579.0CFHR5, CFH, CFP
3complement activationGO:0069568.5CFP, CFH, C4A
4regulation of complement activationGO:0304498.1C4A, C4BPA, CFH, CFP
5innate immune responseGO:0450877.8C4A, C4BPA, CFH, CFP

Products for genes affiliated with Membranoproliferative Glomerulonephritis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Membranoproliferative Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet