MPGN
MCID: MMB001
MIFTS: 47

Membranoproliferative Glomerulonephritis (MPGN) malady

Rare diseases, Nephrological diseases categories

Summaries for Membranoproliferative Glomerulonephritis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Membranoproliferative glomerulonephritis (\"MPGN\"), also known as mesangiocapillary glomerulonephritis,... more...

MalaCards: Membranoproliferative Glomerulonephritis, also known as primary membranoproliferative glomerulonephritis, is related to glomerulonephritis and nephritis. An important gene associated with Membranoproliferative Glomerulonephritis is CFHR5 (complement factor H-related 5), and among its related pathways are Staphylococcus aureus infection and Pertussis. The compounds fibrinogen and cardiolipin have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and b cells.

Aliases & Classifications for Membranoproliferative Glomerulonephritis

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9Disease Ontology, 44NIH Rare Diseases, 23GTR, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

membranoproliferative glomerulonephritis 9 44 23 11
primary membranoproliferative glomerulonephritis 44
membranoproliferative glomerulonephritis nos 9
glomerulonephritis, membranoproliferative 63
glomerulonephritis membranoproliferative 46
mesangiocapillary glomerulonephritis 44
chronic glomerulonephritis, lobular 9
lobular glomerulonephritis 9
mpgn 44


External Ids:

Disease Ontology9 DOID:2920
NCIt41 C34644
SNOMED-CT59 80321008
MeSH36 D015432

Related Diseases for Membranoproliferative Glomerulonephritis

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18GeneCards, 19GeneDecks
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Diseases related to Membranoproliferative Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis32.2CFH, TSLP, CFP
2nephritis30.7C4A, CFP
3dense deposit disease/membranoproliferative glomerulonephritis type ii30.7CFH, CFHR5
4lupus erythematosus30.5CFP, C4A
5systemic lupus erythematosus30.5CFP, CFH, C4BPA, C4A
6complement deficiency30.5C4A, CFP
7atypical hemolytic-uremic syndrome30.3CFH
8acute poststreptococcal glomerulonephritis30.3CFP
9hepatitis11.0
10hepatitis c11.0
11hepatitis c virus10.9
12cryoglobulinemia10.7
13dense deposit disease10.7
14hepatitis b10.6
15leukemia10.5
16nephrotic syndrome10.5
17castleman's disease10.5
18complement factor h deficiency10.5
19lipodystrophy10.5
20glomerulosclerosis10.4
21purpura10.4
22retinitis10.4
23vasculitis10.4
24lupus nephritis10.4
25nephrotic syndrome, type 710.4
26focal segmental glomerulosclerosis10.4
27takayasu's arteritis10.4
28hemolytic-uremic syndrome10.4
29proliferative glomerulonephritis10.4
30crescentic glomerulonephritis10.4
31chronic lymphocytic leukemia10.4
32diabetes mellitus10.4
33liver cirrhosis10.4
34thyroiditis10.4
35cfhr5-related dense deposit disease / membranoproliferative glomerulonephritis type ii10.4
36interstitial nephritis10.3
37diabetic nephropathy10.3
38autoimmune thyroiditis10.3
39strongyloidiasis10.3
40chronic myeloid leukemia10.3
41kaposi's sarcoma10.3
42pulmonary sarcoidosis10.3
43macroglobulinemia10.3
44mantle cell lymphoma10.3
45arthritis10.3
46hypertension10.3
47myeloid leukemia10.3
48pneumonia10.3
49rheumatoid arthritis10.3
50sarcoidosis10.3

Graphical network of the top 20 diseases related to Membranoproliferative Glomerulonephritis:



Diseases related to membranoproliferative glomerulonephritis

Symptoms for Membranoproliferative Glomerulonephritis

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Drugs & Therapeutics for Membranoproliferative Glomerulonephritis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Membranoproliferative Glomerulonephritis

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23GTR
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Genetic tests related to Membranoproliferative Glomerulonephritis:

id Genetic test Affiliating Genes
1 Membranoproliferative Glomerulonephritis23

Anatomical Context for Membranoproliferative Glomerulonephritis

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34MalaCards
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MalaCards organs/tissues related to Membranoproliferative Glomerulonephritis:

34
Kidney, Liver, B cells, Thyroid, Lymph node, Lung, Myeloid, Monocytes, T cells, Testes, Ovary, Eye, Colon, Smooth muscle, Spleen, Endothelial

Animal Models for Membranoproliferative Glomerulonephritis or affiliated genes

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Publications for Membranoproliferative Glomerulonephritis

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53PubMed
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Articles related to Membranoproliferative Glomerulonephritis:

(show top 50)    (show all 493)
idTitleAuthorsYear
1
Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. (21982457)
2012
2
Pathologist's puzzle: Membranoproliferative glomerulonephritis-like features in cryoglobulinemic glomerulonephritis. (22381806)
2012
3
A case of idiopathic membranoproliferative glomerulonephritis with a transient glomerular deposition of nephritis-associated plasmin receptor antigen. (22183562)
2012
4
Cryoglobulinemic membranoproliferative glomerulonephritis: beyond conventional therapy. (21426893)
2011
5
Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis. (21810760)
2011
6
A case of idiopathic basal ganglia calcification associated with membranoproliferative glomerulonephritis. (22001464)
2011
7
Membranoproliferative glomerulonephritis type I in renal transplantation patients: a single-center study of a cohort of 68 renal transplants followed up for 11 years. (21502910)
2011
8
Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. (19528347)
2009
9
A case of autoimmune thyroiditis and membranoproliferative glomerulonephritis. (18008089)
2009
10
Membranoproliferative glomerulonephritis with essential cryoglobulinemia. (20142909)
2008
11
Remission of a B cell CLL-associated membranoproliferative glomerulonephritis Type I with rituximab and bendamustine. (18397703)
2008
12
Nocardial cerebral abscess associated with mycetoma, pneumonia, and membranoproliferative glomerulonephritis. (17428927)
2007
13
Terminal complement complexes in childhood type I membranoproliferative glomerulonephritis. (17173247)
2006
14
Treatment of idiopathic membranoproliferative glomerulonephritis with mycophenolate mofetil and steroids. (15479745)
2004
15
Histopathological atlas of renal diseases. Membranoproliferative glomerulonephritis. (15372408)
2004
16
IgA-associated glomerulonephritis with membranoproliferative glomerulonephritis-like pattern in two children. (14712358)
2003
17
Effects of angiotensin converting enzyme inhibitor on renal function in patients of membranoproliferative glomerulonephritis with mild to moderate renal insufficiency. (12568207)
2002
18
Membranoproliferative glomerulonephritis. (11568249)
2001
19
Response of hepatitis B induced membranoproliferative glomerulonephritis to HAART. (11463942)
2001
20
Decreasing hypocomplementemia and membranoproliferative glomerulonephritis in Japan. (10955929)
2000
21
Tubulointerstitial changes are less important in membranoproliferative glomerulonephritis than in IgA nephropathy. (11015015)
2000
22
Cutaneous telangiectasias, sparse hair, and type I membranoproliferative glomerulonephritis. (10228999)
1999
23
Differences in glomerular leukocyte infiltration between IgA nephropathy and membranoproliferative glomerulonephritis. (9550635)
1998
24
Recurrent type III membranoproliferative glomerulonephritis after kidney transplantation. (9133484)
1997
25
Subretinal fluid associated with membranoproliferative glomerulonephritis type 2. (9230841)
1997
26
Retinal function abnormalities in membranoproliferative glomerulonephritis type II. (9152067)
1997
27
Membranoproliferative glomerulonephritis, p-antineutrophil cytoplasmic antibodies, and rheumatoid arthritis. Report of a case. (8689286)
1996
28
Case for the panel. Unusual ultrastructural association between erythrocytes and glomerular endothelial cells in patients with membranoproliferative glomerulonephritis. (8727072)
1996
29
Intercellular adhesion molecule-1, intercellular adhesion molecule-3, and leukocyte integrins in leukocyte accumulation in membranoproliferative glomerulonephritis type I. (9158205)
1996
30
Expression of intercellular adhesion molecule-1 and vascular adhesion molecule-1 in kidney of patients with lupus nephritis and membranoproliferative glomerulonephritis]. (7544695)
1995
31
Occurrence of C3 nephritic factor and C4 nephritic factor in membranoproliferative glomerulonephritis (MPGN). (8306508)
1994
32
Membranoproliferative glomerulonephritis associated with hepatitis C virus infection. (7510533)
1993
33
DP polymorphism in HLA-A1,-B8,-DR3 extended haplotypes associated with membranoproliferative glomerulonephritis and systemic lupus erythematosus. (8100139)
1993
34
Activation of the alternative pathway of complement by monoclonal lambda light chains in membranoproliferative glomerulonephritis. (1532415)
1992
35
Methyldopa-induced colitis in a patient with membranoproliferative glomerulonephritis. (1504427)
1992
36
Membranoproliferative glomerulonephritis in dogs with a genetically determined deficiency of the third component of complement. (1864020)
1991
37
Fundus changes in chronic membranoproliferative glomerulonephritis type II. (2103524)
1990-1991
38
Patterns of complement activation in idiopathic membranoproliferative glomerulonephritis, types I, II, and III. (2205097)
1990
39
Long-term prognosis of membranoproliferative glomerulonephritis type I. Significance of clinical and morphological parameters: an investigation of 220 cases. (2370922)
1990
40
Long-term follow-up of membranoproliferative glomerulonephritis type II and pregnancy: a case report. (2758699)
1989
41
Regression of recurrent membranoproliferative glomerulonephritis type II in a transplanted kidney after plasmapheresis therapy. (2964750)
1988
42
Differences between membranoproliferative glomerulonephritis types I and III in clinical presentation, glomerular morphology, and complement perturbation. (3826060)
1987
43
Clinico-pathological study of atypical membranoproliferative glomerulonephritis. (3613256)
1987
44
C5 measurement in membranoproliferative glomerulonephritis patients with C3 nephritic factor. (3600936)
1987
45
Tubulo-interstitial alterations in type I membranoproliferative glomerulonephritis. An investigation of 259 cases. (3588405)
1987
46
Major-histocompatibility-complex extended haplotypes in membranoproliferative glomerulonephritis. (3458025)
1986
47
Results of a controlled drug trial in membranoproliferative glomerulonephritis. (3886998)
1985
48
Membranoproliferative glomerulonephritis in a tropical environment. (6625727)
1983
49
Buckley's syndrome and membranoproliferative glomerulonephritis. (7121674)
1982
50
Chronic lymphocytic leukemia and membranoproliferative glomerulonephritis. (6816695)
1982

Variations for Membranoproliferative Glomerulonephritis

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Expression for genes affiliated with Membranoproliferative Glomerulonephritis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Membranoproliferative Glomerulonephritis

Search GEO for disease gene expression data for Membranoproliferative Glomerulonephritis.

Pathways for genes affiliated with Membranoproliferative Glomerulonephritis

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51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 58SinoBiological
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Pathways related to Membranoproliferative Glomerulonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2C4A, CFH
29.1C4A, C4BPA
3
Show member pathways
8.7CFH, C4BPA, C4A
4
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.7C4A, C4BPA, CFH
5
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
8.1C4A, C4BPA, CFH, CFP

Compounds for genes affiliated with Membranoproliferative Glomerulonephritis

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46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB
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Compounds related to Membranoproliferative Glomerulonephritis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1fibrinogen469.5C4BPA, CFH
2cardiolipin46 1210.4CFH, C4BPA
3polysaccharide469.1CFH, CFP
4anaphylatoxin469.0C4A, CFP
5heparin46 30 25 1211.5C4BPA, CFHR5, CFH, CFP

GO Terms for genes affiliated with Membranoproliferative Glomerulonephritis

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17Gene Ontology
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Cellular components related to Membranoproliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9TSLP, CFH, CFP
2blood microparticleGO:0725628.4CFH, C4BPA, C4A
3extracellular regionGO:0055767.5C4A, C4BPA, CFHR5, CFH, CFP

Biological processes related to Membranoproliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement activation, classical pathwayGO:0069589.1C4A, C4BPA
2complement activation, alternative pathwayGO:0069579.0CFHR5, CFH, CFP
3complement activationGO:0069568.5CFP, CFH, C4A
4regulation of complement activationGO:0304498.1C4A, C4BPA, CFH, CFP
5innate immune responseGO:0450877.8C4A, C4BPA, CFH, CFP

Products for genes affiliated with Membranoproliferative Glomerulonephritis

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Sources for Membranoproliferative Glomerulonephritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet