MCID: MMB001
MIFTS: 45

Membranoproliferative Glomerulonephritis malady

Categories: Genetic diseases, Rare diseases, Nephrological diseases

Aliases & Classifications for Membranoproliferative Glomerulonephritis

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Sources:
11Disease Ontology, 13DISEASES, 24GeneTests, 26GTR, 30ICD10 via Orphanet, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 49Novoseek, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Membranoproliferative Glomerulonephritis:

Name: Membranoproliferative Glomerulonephritis 11 47 24 26 13
Mesangiocapillary Glomerulonephritis 47 53 26
Primary Membranoproliferative Glomerulonephritis 47 53
Glomerulonephritis, Membranoproliferative 38 67
Mpgn 47 53
 
Glomerulonephritis Membranoproliferative 49
Chronic Glomerulonephritis, Lobular 11
Lobular Glomerulonephritis 11
Membranoproliferative Gn 24

Characteristics:

Orphanet epidemiological data:

53
mesangiocapillary glomerulonephritis:
Prevalence: 1-5/10000 (Europe)

Classifications:

Orphanet: 53 
Rare renal diseases


External Ids:

Disease Ontology11 DOID:2920
MeSH38 D015432
NCIt44 C34644
Orphanet53 ORPHA54370
SNOMED-CT61 80321008
MESH via Orphanet39 D015432
ICD10 via Orphanet30 N00.5
UMLS via Orphanet68 C0017662

Summaries for Membranoproliferative Glomerulonephritis

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Wikipedia:70 Membranoproliferative glomerulonephritis (\"MPGN\"), also known as mesangiocapillary glomerulonephritis,... more...

MalaCards based summary: Membranoproliferative Glomerulonephritis, also known as mesangiocapillary glomerulonephritis, is related to complement factor h deficiency and c4b deficiency. An important gene associated with Membranoproliferative Glomerulonephritis is PLA2R1 (Phospholipase A2 Receptor 1), and among its related pathways are Staphylococcus aureus infection and Influenza A. Affiliated tissues include kidney, b cells and liver, and related mouse phenotype immune system.

Related Diseases for Membranoproliferative Glomerulonephritis

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Diseases related to Membranoproliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1complement factor h deficiency33.3CD46, CFH
2c4b deficiency30.0C4A, CFP
3hepatitis e30.0C3, ICAM1
4adenocarcinoma29.9ALB, CD79A
5systemic lupus erythematosus28.7ALB, C3, C4A, CD79A, ICAM1
6dense deposit disease/membranoproliferative glomerulonephritis type ii12.2
7cfhr5-related dense deposit disease / membranoproliferative glomerulonephritis type ii12.0
8non-immunoglobulin-mediated membranoproliferative glomerulonephritis12.0
9cfh-related dense deposit disease / membranoproliferative glomerulonephritis type ii12.0
10dense deposit disease11.9
11nephrotic syndrome, type 711.8
12c3 glomerulopathy11.5
13lipodystrophy, partial, acquired11.2
14c3 deficiency11.2
15hypotrichosis-lymphedema-telangiectasia-renal defect syndrome11.1
16glomerulonephritis11.1
17hypotrichosis-lymphedema-telangiectasia syndrome11.0
18hepatitis10.6
19disorders of intracellular cobalamin metabolism10.6CFH, CFHR5
20hepatitis c10.6
21hemolytic uremic syndrome, atypical 110.6CFH, CFHR5
22hepatitis c virus10.5
23glassy cell variant cervical adenosquamous carcinoma10.5C3, CFP
24anti-basement membrane glomerulonephritis10.5C3, CFH
25hemolytic uremic syndrome, atypical 310.5C3, CFP
26ovarian endometrioid stromal sarcoma10.5C3, CD79A
27post-traumatic stress disorder10.5C3, CD79A
28hemochromatosis10.4C3, C4A
29boutonneuse fever10.4ALB, CD79A
30apple allergy10.4CD79A, TSLP
31testicular brenner tumor10.4ALB, CD79A
32hematocele of tunica vaginalis testis10.4ALB, CD79A
33macular degeneration, age-related, 910.4C3, CD46
34sphenoid sinusitis10.4C3, CD79A
35pneumocystosis10.4ALB, C3
36adie pupil10.4ALB, CD79A
37gout susceptibility 410.4C4A, CFP
38pericholangitis10.4ALB, C3
39norse10.4C3, CFH, CFHR5
40acute gonococcal cervicitis10.4ALB, CD79A
41juvenile sialidosis type 210.3C3, C4A
42smoldering myeloma10.3ALB, CD79A
43bartholin's duct cyst10.3C4A, CD79A
44tarp syndrome10.3ALB, CD79A
45spastic monoplegia10.3ALB, CD79A
46b cell linker protein deficiency10.3C4A, CD79A
47cryoglobulinemia10.3
48mast cell neoplasm10.3ALB, CD79A
49catsper1-related nonsyndromic male infertility10.3C3, CFHR5, CFP
50balantidiasis10.3ALB, CD79A

Graphical network of the top 20 diseases related to Membranoproliferative Glomerulonephritis:



Diseases related to membranoproliferative glomerulonephritis

Symptoms for Membranoproliferative Glomerulonephritis

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Drugs & Therapeutics for Membranoproliferative Glomerulonephritis

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Drugs for Membranoproliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ImmunoglobulinsPhase 26045
2AutoantibodiesPhase 2126
3AntibodiesPhase 26045
4Complement System ProteinsPhase 2, Phase 1228
5
Aspirinapproved, vet_approvedPhase 1111250-78-22244
Synonyms:
11126-35-5
11126-37-7
1oxr
2-(ACETYLOXY)benzoic acid
2-(Acetyloxy)benzoate
2-(Acetyloxy)benzoic acid
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoate
2-Acetoxybenzoic acid
2-Carboxyphenyl acetate
2349-94-2
26914-13-6
50-78-2
8-hour Bayer
98201-60-6
A 5376
A.S.A
A.S.A.
A.S.A. Empirin
A.S.A. empirin
A2093_SIGMA
A3160_SIGMA
A5376_SIGMA
A6810_SIGMA
AB1003266
AC 5230
AC1L1D8U
AC1Q1LA0
ACETYLSALICYLIC ACID
AI3-02956
AIN
AKOS000118884
ASA
Acenterine
Acesal
Acetal
Acetard
Aceticyl
Acetilsalicilico
Acetilum acidulatum
Acetisal
Acetol
Acetonyl
Acetophen
Acetosal
Acetosalic acid
Acetosalin
Acetoxybenzoic acid
Acetylin
Acetylsal
Acetylsalicylate
Acetylsalicylic acid
Acetylsalicylsaeure
Acetylsalicylsaure
Acetylsalycilic acid
Acetyonyl
Acetysal
Acetysalicylic acid
Acide 2-(acetyloxy)benzoique
Acide acetylsalicylique
Acide acétylsalicylique
Acido O-acetil-benzoico
Acido acetilsalicilico
Acidum acetylsalicylicum
Acimetten
Acisal
Acylpyrin
Adiro
Aloxiprimum
Asacard
Asagran
Asatard
Ascoden-30
Aspalon
Aspec
Aspergum
Aspir-Mox
Aspirdrops
Aspirin
Aspirin (JP15/USP)
Aspirin [BAN:JAN]
Aspirina 03
Aspirine
Asprin
Aspro
Aspro Clear
Asteric
Azetylsalizylsaeure
Azetylsalizylsäure
BIDD:GT0118
BRN 0779271
Bay-e-4465
Bayer
Bayer Aspirin 8 Hour
Bayer Buffered
Bayer Extra Strength Aspirin For Migraine Pain
Bayer Plus
Benaspir
Bi-prin
Bialpirina
Bialpirinia
Bufferin
C01405
CCRIS 3243
CHEBI:15365
CHEMBL25
CID2244
Caprin
Cardioaspirin
Cardioaspirina
Cemirit
Claradin
Clariprin
Colfarit
Contrheuma retard
Coricidin
Crystar
D00109
D001241
DB00945
Decaten
Delgesic
Dispril
DivK1c_000555
Dolean pH 8
Duramax
ECM
EINECS 200-064-1
EU-0100038
Easprin
Easprin (TN)
Ecolen
Ecotrin
Empirin
Empirin with Codeine
Endosprin
Endydol
 
Entericin
Enterophen
Enterosarein
Enterosarine
Entrophen
Extren
Globentyl
Globoid
HMS1920E13
HMS2090G03
HMS2091K13
HMS501L17
HSDB 652
Helicon
I14-7505
IDI1_000555
Idragin
Istopirin
KBio1_000555
KBio2_001725
KBio2_002271
KBio2_004293
KBio2_004839
KBio2_006861
KBio2_007407
KBio3_002149
KBio3_002751
KBioGR_000398
KBioGR_002271
KBioSS_001725
KBioSS_002272
Kapsazal
Kyselina 2-acetoxybenzoova
Kyselina acetylsalicylova
LS-143
Levius
Lopac-A-5376
Lopac0_000038
MLS001055329
MLS001066332
MLS001336045
MLS001336046
Magnecyl
Measurin
Medisyl
Micristin
MolPort-000-871-622
NCGC00015067-01
NCGC00015067-04
NCGC00015067-09
NCGC00090977-01
NCGC00090977-02
NCGC00090977-03
NCGC00090977-04
NCGC00090977-05
NCGC00090977-06
NCGC00090977-07
NCI60_002222
NINDS_000555
NSC 27223
NSC27223
NSC406186
Neuronika
Novid
Nu-seals
Nu-seals aspirin
O-(Acetyloxy)benzoate
O-(Acetyloxy)benzoic acid
O-Acetoxybenzoate
O-Acetoxybenzoic acid
O-Acetylsalicylic acid
O-Carboxyphenyl acetate
O-accetylsalicylic acid
O-acetylsalicylic acid
PL-2200
Persistin
Pharmacin
Pirseal
Polopirin
Polopiryna
Premaspin
R16CO5Y76E [UNII]
Rheumin tabletten
Rheumintabletten
Rhodine
Rhonal
Ronal
S-211
SMR000059138
SP 189
SPBio_001838
SPECTRUM1500130
ST075414
Salacetin
Salcetogen
Saletin
Salicylic acid acetate
Salicylic acid, acetate
Salospir
Solfrin
Solprin
Solprin acid
Solpyron
Solupsan
Spectrum2_001899
Spectrum3_001295
Spectrum4_000099
Spectrum5_000740
Spectrum_001245
Spira-Dine
St. Joseph
St. Joseph Aspirin for Adults
Supac
Tasprin
Temperal
Toldex
Triaminicin
Triple-sal
UNII R16CO5Y76E
UNII-R16CO5Y76E
UNII=R16CO5Y76E
UNM-0000306102
Vanquish
WLN: QVR BOV1
XAXA
Xaxa
Yasta
ZORprin
aspirin
cMAP_000006
component of Midol
component of Synirin
nchem.859-comp6
o-Acetoxybenzoic acid
o-Carboxyphenyl acetate
o-acetoxybenzoic acid
o-carboxyphenyl acetate
ácido acetilsalicílico
6
rituximabapprovedPhase 11654174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
7VaccinesPhase 16428
8Angiotensin-Converting Enzyme InhibitorsPhase 1711
9Hydroxymethylglutaryl-CoA Reductase InhibitorsPhase 11956
10Antirheumatic AgentsPhase 110627

Interventional clinical trials:

idNameStatusNCT IDPhase
1BG9588 (Anti-CD40L Antibody) to Treat Lupus NephritisCompletedNCT00001789Phase 2
2Eculizumab in Primary MPGNActive, not recruitingNCT02093533Phase 2
3Eculizumab Therapy for Dense Deposit Disease and C3 NephropathyUnknown statusNCT01221181Phase 1
4Pilot Study of Rituximab for Membranoproliferative GlomerulonephritisCompletedNCT00275613Phase 1
5Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit DiseaseTerminatedNCT01791686Phase 1
6Sulodexide Treatment in Patients With Dense Deposit DiseaseWithdrawnNCT00583427Phase 1
7TP10 Use in Patients With C3 Glomerulopathy (C3G)WithdrawnNCT02302755Phase 1

Search NIH Clinical Center for Membranoproliferative Glomerulonephritis


Cochrane evidence based reviews: glomerulonephritis, membranoproliferative

Genetic Tests for Membranoproliferative Glomerulonephritis

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Genetic tests related to Membranoproliferative Glomerulonephritis:

id Genetic test Affiliating Genes
1 Mesangiocapillary Glomerulonephritis26
2 Membranoproliferative Glomerulonephritis26 24 PLA2R1

Anatomical Context for Membranoproliferative Glomerulonephritis

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MalaCards organs/tissues related to Membranoproliferative Glomerulonephritis:

35
Kidney, B cells, Liver, Thyroid, Lymph node, Myeloid, Lung

Animal Models for Membranoproliferative Glomerulonephritis or affiliated genes

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MGI Mouse Phenotypes related to Membranoproliferative Glomerulonephritis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.8C3, CD79A, CFH, CFP, ICAM1, PLA2R1

Publications for Membranoproliferative Glomerulonephritis

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Articles related to Membranoproliferative Glomerulonephritis:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
An unusual case of idiopathic crescentic membranoproliferative glomerulonephritis with posterior reversible encephalopathy syndrome. (27424710)
2016
2
Membranoproliferative glomerulonephritis and C3 glomerulonephritis: Frequency, clinical features, and outcome in children. (25524631)
2015
3
Disseminated strongyloidiasis in a patient with membranoproliferative glomerulonephritis-case report. (25904959)
2015
4
Clinicopathological features of membranoproliferative glomerulonephritis under a new classification. (26445002)
2015
5
Immunoglobulin A dominant membranoproliferative glomerulonephritis in an elderly man: A case report and review of the literature. (26060367)
2015
6
Membranoproliferative glomerulonephritis and Pott's disease. (25852915)
2014
7
Recurrent Membranoproliferative Glomerulonephritis Type I After Kidney Transplantation: A 17-Year Single-Center Experience. (25340602)
2014
8
Familial MPGN - a case series: a clinical description of familial membranoproliferative glomerulonephritis amongst three Irish families. (24975727)
2014
9
Treatment of choroidal neovascularisation secondary to membranoproliferative glomerulonephritis type II with intravitreal ranibizumab. (24895384)
2014
10
A case of idiopathic membranoproliferative glomerulonephritis with a transient glomerular deposition of nephritis-associated plasmin receptor antigen. (22183562)
2012
11
Eculizumab and refractory membranoproliferative glomerulonephritis. (22435384)
2012
12
Rituximab Treatment for PR3-ANCA-Positive Membranoproliferative Glomerulonephritis Associated with Adult-Onset Periodic Fever Syndrome. (23197963)
2012
13
Cryoglobulinemic membranoproliferative glomerulonephritis: beyond conventional therapy. (21426893)
2011
14
A case of idiopathic basal ganglia calcification associated with membranoproliferative glomerulonephritis. (22001464)
2011
15
Membranoproliferative glomerulonephritis type I in renal transplantation patients: a single-center study of a cohort of 68 renal transplants followed up for 11 years. (21502910)
2011
16
Hypokalemic periodic paralysis due to proximal renal tubular acidosis in a case with membranoproliferative glomerulonephritis. (22616344)
2011
17
Membranoproliferative glomerulonephritis with C3NeF and genetic complement dysregulation. (21188423)
2011
18
Macrophages are essential contributors to kidney injury in murine cryoglobulinemic membranoproliferative glomerulonephritis. (21814168)
2011
19
Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. (19528347)
2009
20
Refractory thrombotic thrombocytopenic purpura and membranoproliferative glomerulonephritis successfully treated with rituximab: a case associated with hepatitis C virus infection. (19494376)
2009
21
Remission of a B cell CLL-associated membranoproliferative glomerulonephritis Type I with rituximab and bendamustine. (18397703)
2008
22
Nocardial cerebral abscess associated with mycetoma, pneumonia, and membranoproliferative glomerulonephritis. (17428927)
2007
23
Chronic myeloid leukemia-associated membranoproliferative glomerulonephritis that responded to imatinib mesylate therapy. (17390742)
2007
24
Mycophenolate mofetil use in hepatitis B associated-membranous and membranoproliferative glomerulonephritis induces viral replication. (15671086)
2005
25
Histopathological atlas of renal diseases. Membranoproliferative glomerulonephritis. (15372408)
2004
26
Effects of angiotensin converting enzyme inhibitor on renal function in patients of membranoproliferative glomerulonephritis with mild to moderate renal insufficiency. (12568207)
2002
27
Membranoproliferative glomerulonephritis in association with chronic lymphocytic leukaemia: a report of three cases. (12009095)
2002
28
Response of hepatitis B induced membranoproliferative glomerulonephritis to HAART. (11463942)
2001
29
Effect of acetylsalicylic acid and dipyridamole in primary membranoproliferative glomerulonephritis type I. (12230299)
2001
30
Decreasing hypocomplementemia and membranoproliferative glomerulonephritis in Japan. (10955929)
2000
31
Tubulointerstitial changes are less important in membranoproliferative glomerulonephritis than in IgA nephropathy. (11015015)
2000
32
Membranoproliferative glomerulonephritis. (15912918)
2000
33
Treatment of membranoproliferative glomerulonephritis associated with hepatitis C virus infection. Niigata Research Group of Glomerulonephritis and Nephrotic Syndrome. (11030201)
2000
34
Cutaneous telangiectasias, sparse hair, and type I membranoproliferative glomerulonephritis. (10228999)
1999
35
A rare complication of renal biopsy in a child with membranoproliferative glomerulonephritis. (10195861)
1998
36
Recurrence of membranoproliferative glomerulonephritis in renal allografts. (9838711)
1998
37
Subretinal fluid associated with membranoproliferative glomerulonephritis type 2. (9230841)
1997
38
Case for the panel. Unusual ultrastructural association between erythrocytes and glomerular endothelial cells in patients with membranoproliferative glomerulonephritis. (8727072)
1996
39
Intercellular adhesion molecule-1, intercellular adhesion molecule-3, and leukocyte integrins in leukocyte accumulation in membranoproliferative glomerulonephritis type I. (9158205)
1996
40
Long-term prognosis in idiopathic membranoproliferative glomerulonephritis. (8578267)
1995
41
Membranoproliferative glomerulonephritis associated with hepatitis B and C viral infections: from viruslike particles in the cryoprecipitate to viral localization in paramesangial deposits, problematic investigations prone to artifacts. (8076152)
1994
42
Effect of aspirin and dipyridamole on proteinuria in idiopathic membranoproliferative glomerulonephritis: a multicentre prospective clinical trial. Collaborative Glomerulonephritis Therapy Study Group (CGTS) (7970086)
1994
43
DP polymorphism in HLA-A1,-B8,-DR3 extended haplotypes associated with membranoproliferative glomerulonephritis and systemic lupus erythematosus. (8100139)
1993
44
Activation of the alternative pathway of complement by monoclonal lambda light chains in membranoproliferative glomerulonephritis. (1532415)
1992
45
Membranoproliferative glomerulonephritis in dogs with a genetically determined deficiency of the third component of complement. (1864020)
1991
46
Membranoproliferative glomerulonephritis in Takayasu's arteritis. (1675436)
1991
47
Long-term follow-up of membranoproliferative glomerulonephritis type II and pregnancy: a case report. (2758699)
1989
48
Results of a controlled drug trial in membranoproliferative glomerulonephritis. (3886998)
1985
49
Buckley's syndrome and membranoproliferative glomerulonephritis. (7121674)
1982
50
Associated conditions in childhood membranoproliferative glomerulonephritis during 15 years of experience at the Hacettepe children's hospital. (6763795)
1982

Variations for Membranoproliferative Glomerulonephritis

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Expression for genes affiliated with Membranoproliferative Glomerulonephritis

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Search GEO for disease gene expression data for Membranoproliferative Glomerulonephritis.

Pathways for genes affiliated with Membranoproliferative Glomerulonephritis

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GO Terms for genes affiliated with Membranoproliferative Glomerulonephritis

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Cellular components related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725628.7ALB, C3, C4A, CFH
2extracellular regionGO:00055767.9ALB, C3, C4A, CFH, CFHR5, CFP
3extracellular spaceGO:00056157.4ALB, C3, C4A, CFH, CFP, ICAM1
4extracellular exosomeGO:00700627.1ALB, C3, C4A, CD46, CFH, ICAM1

Biological processes related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of apoptotic cell clearanceGO:20004279.9C3, C4A
2complement activation, alternative pathwayGO:00069579.4C3, CFH, CFHR5, CFP
3complement activationGO:00069568.9C3, C4A, CFH, CFP
4complement activation, classical pathwayGO:00069588.7C3, C4A, CD46
5regulation of complement activationGO:00304497.7C3, C4A, CD46, CFH, CFP

Molecular functions related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00048669.5C3, C4A

Sources for Membranoproliferative Glomerulonephritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet