MPGN
MCID: MMB001
MIFTS: 46

Membranoproliferative Glomerulonephritis (MPGN) malady

Categories: Rare diseases, Genetic diseases, Nephrological diseases

Aliases & Classifications for Membranoproliferative Glomerulonephritis

Aliases & Descriptions for Membranoproliferative Glomerulonephritis:

Name: Membranoproliferative Glomerulonephritis 12 50 24 29 14
Mesangiocapillary Glomerulonephritis 50 56 29
Primary Membranoproliferative Glomerulonephritis 50 56
Glomerulonephritis, Membranoproliferative 42 69
Mpgn 50 56
Glomerulonephritis Membranoproliferative 52
Chronic Glomerulonephritis, Lobular 12
Lobular Glomerulonephritis 12
Membranoproliferative Gn 24

Characteristics:

Orphanet epidemiological data:

56
primary membranoproliferative glomerulonephritis
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 56  
Rare renal diseases


External Ids:

Disease Ontology 12 DOID:2920
MeSH 42 D015432
NCIt 47 C34644
SNOMED-CT 64 80321008
Orphanet 56 ORPHA54370
MESH via Orphanet 43 D015432
ICD10 via Orphanet 34 N00.5
UMLS via Orphanet 70 C0017662
UMLS 69 C0017662

Summaries for Membranoproliferative Glomerulonephritis

MalaCards based summary : Membranoproliferative Glomerulonephritis, also known as mesangiocapillary glomerulonephritis, is related to complement factor h deficiency and c4b deficiency. An important gene associated with Membranoproliferative Glomerulonephritis is PLA2R1 (Phospholipase A2 Receptor 1), and among its related pathways/superpathways are Influenza A and Creation of C4 and C2 activators. The drugs Daratumumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include kidney, b cells and liver, and related phenotype is immune system.

Wikipedia : 71 Membranoproliferative glomerulonephritis (\"MPGN\"), also known as mesangiocapillary glomerulonephritis,... more...

Related Diseases for Membranoproliferative Glomerulonephritis

Diseases related to Membranoproliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
id Related Disease Score Top Affiliating Genes
1 complement factor h deficiency 33.1 CFH CFHR5
2 c4b deficiency 29.8 C4A CFP
3 hepatitis e 29.7 ALB C3
4 dense deposit disease/membranoproliferative glomerulonephritis type ii 12.2
5 cfhr5-related dense deposit disease / membranoproliferative glomerulonephritis type ii 12.0
6 non-immunoglobulin-mediated membranoproliferative glomerulonephritis 12.0
7 cfh-related dense deposit disease / membranoproliferative glomerulonephritis type ii 12.0
8 dense deposit disease 11.9
9 nephrotic syndrome, type 7 11.8
10 c3 glomerulopathy 11.5
11 lipodystrophy, partial, acquired 11.2
12 c3 deficiency 11.2
13 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 11.1
14 glomerulonephritis 11.1
15 hypotrichosis-lymphedema-telangiectasia syndrome 11.0
16 hepatitis 10.6
17 hepatitis c 10.6
18 hepatitis c virus 10.5
19 elane-related neutropenia 10.3 CFH CFHR5
20 cryoglobulinemia 10.3
21 rhizomelic chondrodysplasia punctata 10.3 C3 CFH
22 haemophilus meningitis 10.3 CFH CFP
23 macular degeneration, age-related, 13 10.3 C3 CFP
24 metachronous kidney wilms' tumor 10.2 C3 CD79A
25 chronic mucocutaneous candidiasis 10.2 C3 CD79A
26 blackwater fever 10.2 CD79A CFP
27 atopic dermatitis 6 10.2 ALB CD79A
28 lymphoma 10.2
29 colloid adenoma 10.2 ALB CD79A
30 macular degeneration, age-related, 4 10.2 CD46 CFH
31 schneiderian carcinoma 10.2 ALB CD79A
32 hemochromatosis 10.2 C3 C4A
33 striatonigral degeneration 10.2 ALB CD79A
34 infertility due to extratesticular cause 10.2 ALB CD79A
35 desmoplastic small round cell tumor 10.2 C3 CFH CFHR5
36 male genital organ stricture 10.2 ALB CD79A
37 hepatitis b 10.2
38 gout susceptibility 4 10.2 C4A CFP
39 tarp syndrome 10.2 ALB CD79A
40 coronary artery dissection, spontaneous 10.2 ALB CD79A
41 pdgfra-associated chronic eosinophilic leukemia 10.2 C3 CFHR5 CFP
42 acute cervicitis 10.2 ALB CD79A
43 ciliary discoordination, due to random ciliary orientation 10.2 ALB CD79A
44 hypopharynx cancer 10.2 C4A CD79A
45 apricot allergy 10.2 CD79A TSLP
46 immune-complex glomerulonephritis 10.2 C3 CD79A CFH
47 fibrous histiocytoma 10.1 C3 ICAM1
48 leukemia 10.1
49 tonsil cancer 10.1 CD79A ICAM1
50 good syndrome 10.1 C4A CD79A

Graphical network of the top 20 diseases related to Membranoproliferative Glomerulonephritis:



Diseases related to Membranoproliferative Glomerulonephritis

Symptoms & Phenotypes for Membranoproliferative Glomerulonephritis

MGI Mouse Phenotypes related to Membranoproliferative Glomerulonephritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 PLA2R1 TSLP C3 CD79A CFH CFP

Drugs & Therapeutics for Membranoproliferative Glomerulonephritis

Drugs for Membranoproliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Daratumumab Approved Phase 2 945721-28-8
2 Antibodies Phase 2
3 Autoantibodies Phase 2
4 Immunoglobulins Phase 2
5 Immunoglobulin A Phase 2
6 Complement System Proteins Phase 2,Phase 1
7 Antigen-Antibody Complex Phase 2
8 Antibodies, Monoclonal Phase 2
9
Aspirin Approved, Vet_approved Phase 1 50-78-2 2244
10
rituximab Approved Phase 1 174722-31-7 10201696
11 Angiotensin-Converting Enzyme Inhibitors Phase 1
12 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1
13 Vaccines Phase 1
14 Antirheumatic Agents Phase 1

Interventional clinical trials:

(show all 11)
id Name Status NCT ID Phase
1 Effect of Rituximab in Treatment of Membranoproliferative Glomerulonephritis Not yet recruiting NCT03180723 Phase 3
2 BG9588 (Anti-CD40L Antibody) to Treat Lupus Nephritis Completed NCT00001789 Phase 2
3 Safety Study of IgAN, LN, MN, & C3 Glomerulopathy Including Dense Deposit Disease Treated With OMS721 Recruiting NCT02682407 Phase 2
4 Eculizumab in Primary MPGN Active, not recruiting NCT02093533 Phase 2
5 A Proof-of-Mechanism Study to Determine the Effect of ACH-0144471 on C3 Levels in Patients With C3G or IC-MPGN Not yet recruiting NCT03124368 Phase 2
6 Daratumumab in Treatment of PGNIMD and C3 GN Not yet recruiting NCT03095118 Phase 2
7 Eculizumab Therapy for Dense Deposit Disease and C3 Nephropathy Unknown status NCT01221181 Phase 1
8 Pilot Study of Rituximab for Membranoproliferative Glomerulonephritis Completed NCT00275613 Phase 1
9 Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease Terminated NCT01791686 Phase 1
10 Sulodexide Treatment in Patients With Dense Deposit Disease Withdrawn NCT00583427 Phase 1
11 TP10 Use in Patients With C3 Glomerulopathy (C3G) Withdrawn NCT02302755 Phase 1

Search NIH Clinical Center for Membranoproliferative Glomerulonephritis

Cochrane evidence based reviews: glomerulonephritis, membranoproliferative

Genetic Tests for Membranoproliferative Glomerulonephritis

Genetic tests related to Membranoproliferative Glomerulonephritis:

id Genetic test Affiliating Genes
1 Mesangiocapillary Glomerulonephritis 29
2 Membranoproliferative Glomerulonephritis 29 24 PLA2R1

Anatomical Context for Membranoproliferative Glomerulonephritis

MalaCards organs/tissues related to Membranoproliferative Glomerulonephritis:

39
Kidney, B Cells, Liver, Thyroid, Lymph Node, Lung, Myeloid

Publications for Membranoproliferative Glomerulonephritis

Articles related to Membranoproliferative Glomerulonephritis:

(show top 50) (show all 555)
id Title Authors Year
1
Association of membranoproliferative glomerulonephritis with renal cell carcinoma. ( 28004485 )
2017
2
SjAPgren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis. ( 27904866 )
2016
3
Membranoproliferative Glomerulonephritis Secondary to a Low-Grade Lymphoproliferative Disorder: A Rare Cause of Renal Dysfunction. ( 27812262 )
2016
4
Intravascular large B-cell lymphoma: masquerade as membranoproliferative glomerulonephritis. ( 27312458 )
2016
5
Streptococcal Infection-related Nephritis (SIRN) Manifesting Membranoproliferative Glomerulonephritis Type I. ( 26984084 )
2016
6
Anaerococcus urinomassiliensis sp. nov., isolated from a urine sample of a 17-year-old boy affected by autoimmune hepatitis and membranoproliferative glomerulonephritis. ( 27408746 )
2016
7
Intestinal Intravascular Large B-cell Lymphoma Mimicking Ulcerative Colitis with Secondary Membranoproliferative Glomerulonephritis. ( 27580553 )
2016
8
Differences in clinical findings, pathology, and outcomes between C3 glomerulonephritis and membranoproliferative glomerulonephritis. ( 26846787 )
2016
9
Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN. ( 27458560 )
2016
10
Multimodal imaging of membranoproliferative glomerulonephritis type II. ( 28003788 )
2016
11
Coexistence of atypical hemolytic uremic syndrome with membranoproliferative glomerulonephritis and antineutrophil cytoplasmic antibodies-associated vasculitis. ( 27424702 )
2016
12
Use of C4d as a diagnostic tool to classify membranoproliferative glomerulonephritis. ( 27595516 )
2016
13
Successful Recovery of Acute Renal Transplant Failure in Recurrent Hepatitis C Virus-Associated Membranoproliferative Glomerulonephritis. ( 27778453 )
2016
14
Understanding the complement-mediated glomerular diseases: focus on membranoproliferative glomerulonephritis and C3 glomerulopathies. ( 27356907 )
2016
15
An unusual case of idiopathic crescentic membranoproliferative glomerulonephritis with posterior reversible encephalopathy syndrome. ( 27424710 )
2016
16
An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report. ( 27439394 )
2016
17
Membranoproliferative glomerulonephritis recurrence after kidney transplantation: using the new classification. ( 26754737 )
2016
18
Membranoproliferative glomerulonephritis and acute renal failure in a patient with chronic lymphocytic leukemia: Response to obinutuzumab. ( 27352257 )
2016
19
Manifestations of Complement-Mediated and Immune Complex-Mediated Membranoproliferative Glomerulonephritis: A Comparative Consecutive Series. ( 26996341 )
2016
20
Novel factor H mutation associated with familial membranoproliferative glomerulonephritis type I. ( 26289290 )
2015
21
Glomerular Diseases Dependent on Complement Activation, Including Atypical Hemolytic Uremic Syndrome, Membranoproliferative Glomerulonephritis, and C3 Glomerulopathy: Core Curriculum 2015. ( 26032627 )
2015
22
Type of immune and complement deposits and response of immunosuppressive treatment on Membranoproliferative Glomerulonephritis -- a single centre experience. ( 26338748 )
2015
23
Treatment-resistant recurrent membranoproliferative glomerulonephritis in renal allograft responding to rituximab: case report. ( 25891740 )
2015
24
Immunoglobulin A dominant membranoproliferative glomerulonephritis in an elderly man: A case report and review of the literature. ( 26060367 )
2015
25
A case of membranoproliferative glomerulonephritis associated with curved fibril deposition. ( 26370133 )
2015
26
Successful treatment of hepatitis E virus-associated cryoglobulinemic membranoproliferative glomerulonephritis with ribavirin. ( 25708383 )
2015
27
Polyarthritis and membranoproliferative glomerulonephritis as paraneoplastic manifestation of Hodgkin's lymphoma: A case report and literature review. ( 26654571 )
2015
28
Clinicopathological features of membranoproliferative glomerulonephritis under a new classification. ( 26445002 )
2015
29
Membranoproliferative glomerulonephritis in a puerperal with SjAPgren's syndrome: Rare finding or something else? ( 26306976 )
2015
30
A Case of Cryoglobulinemic Membranoproliferative Glomerulonephritis Induced by Hepatitis C Virus. ( 26328796 )
2015
31
Membranoproliferative glomerulonephritis with predominant IgG2 and IgG3 deposition in a patient with IgG4-related disease. ( 26502965 )
2015
32
AJKD Atlas of Renal Pathology: Membranoproliferative Glomerulonephritis. ( 26300204 )
2015
33
Disseminated strongyloidiasis in a patient with membranoproliferative glomerulonephritis-case report. ( 25904959 )
2015
34
Renal interstitial mast cell count is significantly higher in membranoproliferative glomerulonephritis than in class IV lupus nephritis. ( 26247528 )
2015
35
SHEDDING LIGHT ON FUNDUS DRUSEN ASSOCIATED WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS: BREAKING STEREOTYPES OF TYPES I, II, AND III. ( 26110522 )
2015
36
The incidence of possible causes of membranoproliferative glomerulonephritis: a single-center experience. ( 27688695 )
2015
37
Membranoproliferative glomerulonephritis with masked monotypic immunoglobulin deposits. ( 26154922 )
2015
38
Membranoproliferative glomerulonephritis and C3 glomerulonephritis: Frequency, clinical features, and outcome in children. ( 25524631 )
2015
39
Morphological changes in membranoproliferative glomerulonephritis - a quantitative approach. ( 26743276 )
2015
40
Early rehabilitation of a child with intensive care unit acquired weakness secondary to membranoproliferative glomerulonephritis: A case report. ( 27186711 )
2015
41
Membranoproliferative glomerulonephritis due to visceral leishmaniasis in an HIV patient. ( 25575099 )
2015
42
Membranoproliferative glomerulonephritis, type II cryoglobulinemia and triple therapy for hepatitis C: a case series and review of the literature. ( 24633573 )
2014
43
Treatment of choroidal neovascularisation secondary to membranoproliferative glomerulonephritis type II with intravitreal ranibizumab. ( 24895384 )
2014
44
Rituximab in a B cell-driven regimen for the treatment of recurrent membranoproliferative glomerulonephritis after kidney transplantation. ( 25080208 )
2014
45
Recombinant Human Erythropoietin (RHuEpo) and Granular Colony Stimulating Factor (G-CSF) in hepatitis C virus (HCV) related to mixed cryoglobulinaemia associated to membranoproliferative glomerulonephritis type I: a case report description. ( 25551853 )
2014
46
Eculizumab in the Treatment of Membranoproliferative Glomerulonephritis. ( 25402185 )
2014
47
Renal Pathology: SY23-1 CURRENT APPROACH TO CLASSIFICATION OF MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS. ( 25188169 )
2014
48
IgA Nephropathy with Pathologic Features of Membranoproliferative Glomerulonephritis following Burn Injury. ( 24707281 )
2014
49
Membranoproliferative glomerulonephritis associated with autoimmune diseases. ( 24500888 )
2014
50
Splenic Marginal Zone Lymphoma and Concurrent Membranoproliferative Glomerulonephritis With IgMKappa Deposits in a HCV-Seropositive Patient. ( 25695019 )
2014

Variations for Membranoproliferative Glomerulonephritis

Expression for Membranoproliferative Glomerulonephritis

Search GEO for disease gene expression data for Membranoproliferative Glomerulonephritis.

Pathways for Membranoproliferative Glomerulonephritis

GO Terms for Membranoproliferative Glomerulonephritis

Cellular components related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.87 ALB C3 C4A CD46 CFH ICAM1
2 endoplasmic reticulum lumen GO:0005788 9.56 ALB C3 C4A CFP
3 extracellular region GO:0005576 9.56 ALB C3 C4A CFH CFHR5 CFP
4 blood microparticle GO:0072562 9.46 ALB C3 C4A CFH
5 extracellular space GO:0005615 9.17 ALB C3 C4A CFH CFP ICAM1

Biological processes related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.71 C3 C4A CD46 CD79A
2 innate immune response GO:0045087 9.65 C3 C4A CD46 CFH CFP
3 cellular protein metabolic process GO:0044267 9.61 ALB C3 C4A
4 complement activation, classical pathway GO:0006958 9.54 C3 C4A CD46
5 complement activation GO:0006956 9.46 C3 C4A CFH CFP
6 positive regulation of apoptotic cell clearance GO:2000427 9.32 C3 C4A
7 complement activation, alternative pathway GO:0006957 9.26 C3 CFH CFHR5 CFP
8 regulation of complement activation GO:0030449 9.1 C3 C4A CD46 CFH CFHR5 CFP

Molecular functions related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.62 C3 C4A

Sources for Membranoproliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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