MCID: MMB001
MIFTS: 42

Membranoproliferative Glomerulonephritis malady

Rare diseases, Nephrological diseases categories

Summaries for Membranoproliferative Glomerulonephritis

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Wikipedia:63 Membranoproliferative glomerulonephritis (\"MPGN\"), also known as mesangiocapillary glomerulonephritis,... more...

MalaCards based summary: Membranoproliferative Glomerulonephritis, also known as primary membranoproliferative glomerulonephritis, is related to glomerulonephritis and dense deposit disease/membranoproliferative glomerulonephritis type ii. An important gene associated with Membranoproliferative Glomerulonephritis is CFHR5 (complement factor H-related 5), and among its related pathways are Staphylococcus aureus infection and Pertussis. The compounds fibrinogen and cardiolipin have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and b cells.

Aliases & Classifications for Membranoproliferative Glomerulonephritis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 22GTR, 60UMLS, 33MeSH, 38NCIt, 55SNOMED-CT, 34MESH via Orphanet, 61UMLS via Orphanet
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Membranoproliferative Glomerulonephritis, Aliases & Descriptions:

Name: Membranoproliferative Glomerulonephritis 9 41 11
Primary Membranoproliferative Glomerulonephritis 41 47
Glomerulonephritis Membranoproliferative 43 22
Mesangiocapillary Glomerulonephritis 41 47
Mpgn 41 47
 
Membranoproliferative Glomerulonephritis Nos 9
Glomerulonephritis, Membranoproliferative 60
Chronic Glomerulonephritis, Lobular 9
Lobular Glomerulonephritis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases
Orphanet: 47 
Rare renal diseases


Characteristics (Orphanet epidemiological data):

47
primary membranoproliferative glomerulonephritis:
Prevalence: 1-5/10000 (Europe)


External Ids:

Disease Ontology9 DOID:2920
MeSH33 D015432
NCIt38 C34644
SNOMED-CT55 80321008
Orphanet47 54370
MESH via Orphanet34 D015432
UMLS via Orphanet61 C0017662

Related Diseases for Membranoproliferative Glomerulonephritis

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Diseases related to Membranoproliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis32.0TSLP, CFH, CFP
2dense deposit disease/membranoproliferative glomerulonephritis type ii31.1CFHR5, CFH
3acute poststreptococcal glomerulonephritis30.6CFP
4lupus erythematosus30.4C4A, CFP
5nephritis30.4C4A, CFP
6complement deficiency30.4C4A, CFP
7systemic lupus erythematosus29.9CFP, CFH, C4BPA, C4A
8hepatitis11.1
9hepatitis c11.0
10hepatitis c virus10.9
11cryoglobulinemia10.7
12dense deposit disease10.7
13hepatitis b10.6
14leukemia10.6
15nephrotic syndrome10.6
16castleman's disease10.5
17lipodystrophy10.5
18vasculitis10.5
19chronic lymphocytic leukemia10.4
20glomerulosclerosis10.4
21purpura10.4
22retinitis10.4
23lupus nephritis10.4
24cfhr5-related dense deposit disease / membranoproliferative glomerulonephritis type ii10.4
25non-immunoglobulin-mediated membranoproliferative glomerulonephritis10.4
26immunoglobulin-mediated membranoproliferative glomerulonephritis10.4
27lipodystrophy, partial, acquired10.4
28focal segmental glomerulosclerosis10.4
29liver cirrhosis10.4
30strongyloidiasis10.4
31takayasu's arteritis10.4
32proliferative glomerulonephritis10.4
33crescentic glomerulonephritis10.4
34thyroiditis10.4
35cfh-related dense deposit disease / membranoproliferative glomerulonephritis type ii10.4
36interstitial nephritis10.3
37hemolytic uremic syndrome, atypical 110.3CFH
38rheumatoid arthritis10.3
39complement factor h deficiency10.3
40c3 deficiency10.3
41arthritis10.3
42mantle cell lymphoma10.3
43autoimmune thyroiditis10.3
44hemolytic-uremic syndrome10.3
45macroglobulinemia10.3
46agammaglobulinemia10.3
47myeloid leukemia10.3
48pneumonia10.3
49sarcoma10.3
50sickle cell disease10.3

Graphical network of the top 20 diseases related to Membranoproliferative Glomerulonephritis:



Diseases related to membranoproliferative glomerulonephritis

Symptoms for Membranoproliferative Glomerulonephritis

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Drugs & Therapeutics for Membranoproliferative Glomerulonephritis

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Drug clinical trials:

Search ClinicalTrials for Membranoproliferative Glomerulonephritis

Search NIH Clinical Center for Membranoproliferative Glomerulonephritis

Genetic Tests for Membranoproliferative Glomerulonephritis

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Genetic tests related to Membranoproliferative Glomerulonephritis:

id Genetic test Affiliating Genes
1 Membranoproliferative Glomerulonephritis22

Anatomical Context for Membranoproliferative Glomerulonephritis

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MalaCards organs/tissues related to Membranoproliferative Glomerulonephritis:

31
Kidney, Liver, B cells, Lymph node, Thyroid, Lung, Myeloid, Eye, Spleen, Smooth muscle, Colon, Ovary, Testes, Monocytes, T cells, Endothelial

Animal Models for Membranoproliferative Glomerulonephritis or affiliated genes

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Publications for Membranoproliferative Glomerulonephritis

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Articles related to Membranoproliferative Glomerulonephritis:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Successful treatment of hepatitis E virus-associated cryoglobulinemic membranoproliferative glomerulonephritis with ribavirin. (25708383)
2015
2
Membranoproliferative glomerulonephritis and Pott's disease. (25852915)
2014
3
Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. (21982457)
2012
4
Pathologist's puzzle: Membranoproliferative glomerulonephritis-like features in cryoglobulinemic glomerulonephritis. (22381806)
2012
5
A case of idiopathic membranoproliferative glomerulonephritis with a transient glomerular deposition of nephritis-associated plasmin receptor antigen. (22183562)
2012
6
Cryoglobulinemic membranoproliferative glomerulonephritis: beyond conventional therapy. (21426893)
2011
7
Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis. (21810760)
2011
8
A case of idiopathic basal ganglia calcification associated with membranoproliferative glomerulonephritis. (22001464)
2011
9
Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. (19528347)
2009
10
A case of autoimmune thyroiditis and membranoproliferative glomerulonephritis. (18008089)
2009
11
Membranoproliferative glomerulonephritis with essential cryoglobulinemia. (20142909)
2008
12
Remission of a B cell CLL-associated membranoproliferative glomerulonephritis Type I with rituximab and bendamustine. (18397703)
2008
13
Nocardial cerebral abscess associated with mycetoma, pneumonia, and membranoproliferative glomerulonephritis. (17428927)
2007
14
Terminal complement complexes in childhood type I membranoproliferative glomerulonephritis. (17173247)
2006
15
Treatment of idiopathic membranoproliferative glomerulonephritis with mycophenolate mofetil and steroids. (15479745)
2004
16
Histopathological atlas of renal diseases. Membranoproliferative glomerulonephritis. (15372408)
2004
17
IgA-associated glomerulonephritis with membranoproliferative glomerulonephritis-like pattern in two children. (14712358)
2003
18
Effects of angiotensin converting enzyme inhibitor on renal function in patients of membranoproliferative glomerulonephritis with mild to moderate renal insufficiency. (12568207)
2002
19
Membranoproliferative glomerulonephritis. (11568249)
2001
20
Response of hepatitis B induced membranoproliferative glomerulonephritis to HAART. (11463942)
2001
21
Decreasing hypocomplementemia and membranoproliferative glomerulonephritis in Japan. (10955929)
2000
22
Tubulointerstitial changes are less important in membranoproliferative glomerulonephritis than in IgA nephropathy. (11015015)
2000
23
Cutaneous telangiectasias, sparse hair, and type I membranoproliferative glomerulonephritis. (10228999)
1999
24
Differences in glomerular leukocyte infiltration between IgA nephropathy and membranoproliferative glomerulonephritis. (9550635)
1998
25
Recurrent type III membranoproliferative glomerulonephritis after kidney transplantation. (9133484)
1997
26
Subretinal fluid associated with membranoproliferative glomerulonephritis type 2. (9230841)
1997
27
Membranoproliferative glomerulonephritis, p-antineutrophil cytoplasmic antibodies, and rheumatoid arthritis. Report of a case. (8689286)
1996
28
Case for the panel. Unusual ultrastructural association between erythrocytes and glomerular endothelial cells in patients with membranoproliferative glomerulonephritis. (8727072)
1996
29
Intercellular adhesion molecule-1, intercellular adhesion molecule-3, and leukocyte integrins in leukocyte accumulation in membranoproliferative glomerulonephritis type I. (9158205)
1996
30
Expression of intercellular adhesion molecule-1 and vascular adhesion molecule-1 in kidney of patients with lupus nephritis and membranoproliferative glomerulonephritis]. (7544695)
1995
31
Occurrence of C3 nephritic factor and C4 nephritic factor in membranoproliferative glomerulonephritis (MPGN). (8306508)
1994
32
Membranoproliferative glomerulonephritis associated with hepatitis C virus infection. (7510533)
1993
33
DP polymorphism in HLA-A1,-B8,-DR3 extended haplotypes associated with membranoproliferative glomerulonephritis and systemic lupus erythematosus. (8100139)
1993
34
Activation of the alternative pathway of complement by monoclonal lambda light chains in membranoproliferative glomerulonephritis. (1532415)
1992
35
Methyldopa-induced colitis in a patient with membranoproliferative glomerulonephritis. (1504427)
1992
36
Membranoproliferative glomerulonephritis in dogs with a genetically determined deficiency of the third component of complement. (1864020)
1991
37
Fundus changes in chronic membranoproliferative glomerulonephritis type II. (2103524)
1990-1991
38
Patterns of complement activation in idiopathic membranoproliferative glomerulonephritis, types I, II, and III. (2205097)
1990
39
Long-term prognosis of membranoproliferative glomerulonephritis type I. Significance of clinical and morphological parameters: an investigation of 220 cases. (2370922)
1990
40
Long-term follow-up of membranoproliferative glomerulonephritis type II and pregnancy: a case report. (2758699)
1989
41
Regression of recurrent membranoproliferative glomerulonephritis type II in a transplanted kidney after plasmapheresis therapy. (2964750)
1988
42
Differences between membranoproliferative glomerulonephritis types I and III in clinical presentation, glomerular morphology, and complement perturbation. (3826060)
1987
43
Clinico-pathological study of atypical membranoproliferative glomerulonephritis. (3613256)
1987
44
C5 measurement in membranoproliferative glomerulonephritis patients with C3 nephritic factor. (3600936)
1987
45
Tubulo-interstitial alterations in type I membranoproliferative glomerulonephritis. An investigation of 259 cases. (3588405)
1987
46
Major-histocompatibility-complex extended haplotypes in membranoproliferative glomerulonephritis. (3458025)
1986
47
Results of a controlled drug trial in membranoproliferative glomerulonephritis. (3886998)
1985
48
Membranoproliferative glomerulonephritis in a tropical environment. (6625727)
1983
49
Buckley's syndrome and membranoproliferative glomerulonephritis. (7121674)
1982
50
Chronic lymphocytic leukemia and membranoproliferative glomerulonephritis. (6816695)
1982

Variations for Membranoproliferative Glomerulonephritis

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Clinvar genetic disease variations for Membranoproliferative Glomerulonephritis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1CFHR5CFHR5, EX2-3, DUPcopy number gainPathogenic
2CFHR5CFHR5, 1-BP INS, 485AinsertionPathogenic

Expression for genes affiliated with Membranoproliferative Glomerulonephritis

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Search GEO for disease gene expression data for Membranoproliferative Glomerulonephritis.

Pathways for genes affiliated with Membranoproliferative Glomerulonephritis

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Pathways related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2C4A, CFH
29.1C4A, C4BPA
3
Show member pathways
8.7CFH, C4BPA, C4A
4
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.7C4A, C4BPA, CFH
5
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
8.1C4A, C4BPA, CFH, CFP

Compounds for genes affiliated with Membranoproliferative Glomerulonephritis

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Sources:
43Novoseek, 12DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1fibrinogen439.5C4BPA, CFH
2cardiolipin43 1210.4CFH, C4BPA
3polysaccharide439.1CFH, CFP
4anaphylatoxin439.0C4A, CFP
5heparin43 28 24 1211.5C4BPA, CFHR5, CFH, CFP

GO Terms for genes affiliated with Membranoproliferative Glomerulonephritis

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Cellular components related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.9TSLP, CFH, CFP
2blood microparticleGO:00725628.4CFH, C4BPA, C4A
3extracellular regionGO:00055767.5C4A, C4BPA, CFHR5, CFH, CFP

Biological processes related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1complement activation, classical pathwayGO:00069589.1C4A, C4BPA
2complement activation, alternative pathwayGO:00069579.0CFHR5, CFH, CFP
3complement activationGO:00069568.5CFP, CFH, C4A
4regulation of complement activationGO:00304498.1C4A, C4BPA, CFH, CFP
5innate immune responseGO:00450877.8C4A, C4BPA, CFH, CFP

Products for genes affiliated with Membranoproliferative Glomerulonephritis

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Sources for Membranoproliferative Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet