MPGN
MCID: MMB001
MIFTS: 46

Membranoproliferative Glomerulonephritis (MPGN) malady

Categories: Genetic diseases, Rare diseases, Nephrological diseases

Aliases & Classifications for Membranoproliferative Glomerulonephritis

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Sources:
11Disease Ontology, 13DISEASES, 24GeneTests, 27GTR, 31ICD10 via Orphanet, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Membranoproliferative Glomerulonephritis:

Name: Membranoproliferative Glomerulonephritis 11 48 24 27 13
Mesangiocapillary Glomerulonephritis 48 54 27
Primary Membranoproliferative Glomerulonephritis 48 54
Glomerulonephritis, Membranoproliferative 39 68
Mpgn 48 54
 
Glomerulonephritis Membranoproliferative 50
Chronic Glomerulonephritis, Lobular 11
Lobular Glomerulonephritis 11
Membranoproliferative Gn 24

Characteristics:

Orphanet epidemiological data:

54
mesangiocapillary glomerulonephritis:
Prevalence: 1-5/10000 (Europe)

Classifications:

Orphanet: 54 
Rare renal diseases


External Ids:

Disease Ontology11 DOID:2920
MeSH39 D015432
NCIt45 C34644
Orphanet54 ORPHA54370
SNOMED-CT62 80321008
MESH via Orphanet40 D015432
ICD10 via Orphanet31 N00.5
UMLS via Orphanet69 C0017662

Summaries for Membranoproliferative Glomerulonephritis

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Wikipedia:71 Membranoproliferative glomerulonephritis (\"MPGN\"), also known as mesangiocapillary glomerulonephritis,... more...

MalaCards based summary: Membranoproliferative Glomerulonephritis, also known as mesangiocapillary glomerulonephritis, is related to complement factor h deficiency and c4b deficiency. An important gene associated with Membranoproliferative Glomerulonephritis is PLA2R1 (Phospholipase A2 Receptor 1), and among its related pathways are Complement and coagulation cascades and Creation of C4 and C2 activators. Affiliated tissues include kidney, b cells and liver, and related mouse phenotype immune system.

Related Diseases for Membranoproliferative Glomerulonephritis

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Diseases related to Membranoproliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1complement factor h deficiency33.1CFH, CFHR5
2c4b deficiency29.8C4A, CFP
3hepatitis e29.7ALB, C3
4dense deposit disease/membranoproliferative glomerulonephritis type ii12.2
5cfhr5-related dense deposit disease / membranoproliferative glomerulonephritis type ii12.0
6non-immunoglobulin-mediated membranoproliferative glomerulonephritis12.0
7cfh-related dense deposit disease / membranoproliferative glomerulonephritis type ii12.0
8dense deposit disease11.9
9nephrotic syndrome, type 711.8
10c3 glomerulopathy11.5
11lipodystrophy, partial, acquired11.2
12c3 deficiency11.2
13hypotrichosis-lymphedema-telangiectasia-renal defect syndrome11.1
14glomerulonephritis11.1
15hypotrichosis-lymphedema-telangiectasia syndrome11.0
16hepatitis10.6
17hepatitis c10.6
18hepatitis c virus10.5
19elane-related neutropenia10.3CFH, CFHR5
20cryoglobulinemia10.3
21rhizomelic chondrodysplasia punctata10.3C3, CFH
22haemophilus meningitis10.3CFH, CFP
23macular degeneration, age-related, 1310.3C3, CFP
24metachronous kidney wilms' tumor10.2C3, CD79A
25chronic mucocutaneous candidiasis10.2C3, CD79A
26blackwater fever10.2CD79A, CFP
27atopic dermatitis 610.2ALB, CD79A
28lymphoma10.2
29colloid adenoma10.2ALB, CD79A
30macular degeneration, age-related, 410.2CD46, CFH
31schneiderian carcinoma10.2ALB, CD79A
32hemochromatosis10.2C3, C4A
33striatonigral degeneration10.2ALB, CD79A
34infertility due to extratesticular cause10.2ALB, CD79A
35desmoplastic small round cell tumor10.2C3, CFH, CFHR5
36male genital organ stricture10.2ALB, CD79A
37hepatitis b10.2
38gout susceptibility 410.2C4A, CFP
39tarp syndrome10.2ALB, CD79A
40coronary artery dissection, spontaneous10.2ALB, CD79A
41pdgfra-associated chronic eosinophilic leukemia10.2C3, CFHR5, CFP
42acute cervicitis10.2ALB, CD79A
43ciliary discoordination, due to random ciliary orientation10.2ALB, CD79A
44hypopharynx cancer10.2C4A, CD79A
45apricot allergy10.2CD79A, TSLP
46immune-complex glomerulonephritis10.2C3, CD79A, CFH
47fibrous histiocytoma10.1C3, ICAM1
48leukemia10.1
49tonsil cancer10.1CD79A, ICAM1
50good syndrome10.1C4A, CD79A

Graphical network of the top 20 diseases related to Membranoproliferative Glomerulonephritis:



Diseases related to membranoproliferative glomerulonephritis

Symptoms & Phenotypes for Membranoproliferative Glomerulonephritis

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MGI Mouse Phenotypes related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.5C3, CD79A, CFH, CFP, ICAM1, PLA2R1

Drugs & Therapeutics for Membranoproliferative Glomerulonephritis

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Drugs for Membranoproliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DaratumumabapprovedPhase 251945721-28-8
Synonyms:
 
HuMax-CD38
2AntibodiesPhase 26394
3ImmunoglobulinsPhase 26394
4AutoantibodiesPhase 2130
5Immunoglobulin APhase 2120
6Complement System ProteinsPhase 2, Phase 1232
7Antibodies, MonoclonalPhase 24039
8Antigen-Antibody ComplexPhase 210
9
Aspirinapproved, vet_approvedPhase 1115250-78-22244
Synonyms:
11126-35-5
11126-37-7
1oxr
2-(Acetyloxy)benzoate
2-(Acetyloxy)benzoic acid
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoate
2-Acetoxybenzoic acid
2-Carboxyphenyl acetate
2349-94-2
26914-13-6
50-78-2
8-hour Bayer
98201-60-6
A 5376
A.S.A
A.S.A.
A.S.A. Empirin
A.S.A. empirin
A2093_SIGMA
A3160_SIGMA
A5376_SIGMA
A6810_SIGMA
AB1003266
AC 5230
AC1L1D8U
AC1Q1LA0
ACETYLSALICYLIC ACID
AI3-02956
AIN
AKOS000118884
ASA
Acenterine
Acesal
Acetal
Acetard
Aceticyl
Acetilsalicilico
Acetilum acidulatum
Acetisal
Acetol
Acetonyl
Acetophen
Acetosal
Acetosalic acid
Acetosalin
Acetoxybenzoic acid
Acetylin
Acetylsal
Acetylsalicylate
Acetylsalicylic acid
Acetylsalicylsaeure
Acetylsalicylsaure
Acetylsalicylsäure
Acetylsalycilic acid
Acetyonyl
Acetysal
Acetysalicylic acid
Acide acetylsalicylique
Acido O-acetil-benzoico
Acido acetilsalicilico
Acidum acetylsalicylicum
Acimetten
Acisal
Acylpyrin
Adiro
Aloxiprimum
Asacard
Asagran
Asatard
Ascoden-30
Aspalon
Aspec
Aspergum
Aspir-Mox
Aspirdrops
Aspirin
Aspirin (JP15/USP)
Aspirin [BAN:JAN]
Aspirina 03
Aspirine
Asprin
Aspro
Aspro Clear
Asteric
Azetylsalizylsaeure
Azetylsalizylsäure
BIDD:GT0118
BRN 0779271
Bay-e-4465
Bayer
Bayer Aspirin 8 Hour
Bayer Buffered
Bayer Extra Strength Aspirin For Migraine Pain
Bayer Plus
Benaspir
Bi-prin
Bialpirina
Bialpirinia
Bufferin
C01405
CCRIS 3243
CHEBI:15365
CHEMBL25
CID2244
Caprin
Cardioaspirin
Cardioaspirina
Cemirit
Claradin
Clariprin
Colfarit
Contrheuma retard
Coricidin
Crystar
D00109
D001241
DB00945
Decaten
Delgesic
Dispril
DivK1c_000555
Dolean pH 8
Duramax
ECM
EINECS 200-064-1
EU-0100038
Easprin
Easprin (TN)
Ecolen
Ecotrin
Empirin
Empirin with Codeine
Endosprin
Endydol
Entericin
Enterophen
 
Enterosarein
Enterosarine
Entrophen
Extren
Globentyl
Globoid
HMS1920E13
HMS2090G03
HMS2091K13
HMS501L17
HSDB 652
Helicon
I14-7505
IDI1_000555
Idragin
Istopirin
KBio1_000555
KBio2_001725
KBio2_002271
KBio2_004293
KBio2_004839
KBio2_006861
KBio2_007407
KBio3_002149
KBio3_002751
KBioGR_000398
KBioGR_002271
KBioSS_001725
KBioSS_002272
Kapsazal
Kyselina 2-acetoxybenzoova
Kyselina acetylsalicylova
LS-143
Levius
Lopac-A-5376
Lopac0_000038
MLS001055329
MLS001066332
MLS001336045
MLS001336046
Magnecyl
Measurin
Medisyl
Micristin
MolPort-000-871-622
NCGC00015067-01
NCGC00015067-04
NCGC00015067-09
NCGC00090977-01
NCGC00090977-02
NCGC00090977-03
NCGC00090977-04
NCGC00090977-05
NCGC00090977-06
NCGC00090977-07
NCI60_002222
NINDS_000555
NSC 27223
NSC27223
NSC406186
Neuronika
Novid
Nu-seals
Nu-seals aspirin
O-(Acetyloxy)benzoate
O-(Acetyloxy)benzoic acid
O-Acetoxybenzoate
O-Acetoxybenzoic acid
O-Acetylsalicylic acid
O-Carboxyphenyl acetate
O-accetylsalicylic acid
O-acetylsalicylic acid
PL-2200
Persistin
Pharmacin
Pirseal
Polopirin
Polopiryna
Premaspin
R16CO5Y76E [UNII]
Rheumin tabletten
Rheumintabletten
Rhodine
Rhonal
Ronal
S-211
SMR000059138
SP 189
SPBio_001838
SPECTRUM1500130
ST075414
Salacetin
Salcetogen
Saletin
Salicylic acid acetate
Salicylic acid, acetate
Salospir
Solfrin
Solprin
Solprin acid
Solpyron
Solupsan
Spectrum2_001899
Spectrum3_001295
Spectrum4_000099
Spectrum5_000740
Spectrum_001245
Spira-Dine
St. Joseph
St. Joseph Aspirin for Adults
Supac
Tasprin
Temperal
Toldex
Triaminicin
Triple-sal
UNII R16CO5Y76E
UNII-R16CO5Y76E
UNII=R16CO5Y76E
UNM-0000306102
Vanquish
WLN: QVR BOV1
XAXA
Xaxa
Yasta
ZORprin
acide 2-(acétyloxy)benzoïque
acide acétylsalicylique
aspirin
cMAP_000006
component of Midol
component of Synirin
nchem.859-comp6
o-Acetoxybenzoic acid
o-Carboxyphenyl acetate
o-acetoxybenzoic acid
o-carboxyphenyl acetate
salicylic acid acetate
ácido acetilsalicílico
10
rituximabapprovedPhase 11692174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
11VaccinesPhase 16611
12Hydroxymethylglutaryl-CoA Reductase InhibitorsPhase 11998
13Angiotensin-Converting Enzyme InhibitorsPhase 1724
14Antirheumatic AgentsPhase 110956

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Effect of Rituximab in Treatment of Membranoproliferative GlomerulonephritisNot yet recruitingNCT03180723Phase 3
2BG9588 (Anti-CD40L Antibody) to Treat Lupus NephritisCompletedNCT00001789Phase 2
3Safety Study of IgAN, LN, MN, & C3 Glomerulopathy Including Dense Deposit Disease Treated With OMS721RecruitingNCT02682407Phase 2
4Eculizumab in Primary MPGNActive, not recruitingNCT02093533Phase 2
5A Proof-of-Mechanism Study to Determine the Effect of ACH-0144471 on C3 Levels in Patients With C3G or IC-MPGNNot yet recruitingNCT03124368Phase 2
6Daratumumab in Treatment of PGNIMD and C3 GNNot yet recruitingNCT03095118Phase 2
7Eculizumab Therapy for Dense Deposit Disease and C3 NephropathyUnknown statusNCT01221181Phase 1
8Pilot Study of Rituximab for Membranoproliferative GlomerulonephritisCompletedNCT00275613Phase 1
9Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit DiseaseTerminatedNCT01791686Phase 1
10Sulodexide Treatment in Patients With Dense Deposit DiseaseWithdrawnNCT00583427Phase 1
11TP10 Use in Patients With C3 Glomerulopathy (C3G)WithdrawnNCT02302755Phase 1

Search NIH Clinical Center for Membranoproliferative Glomerulonephritis


Cochrane evidence based reviews: glomerulonephritis, membranoproliferative

Genetic Tests for Membranoproliferative Glomerulonephritis

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Genetic tests related to Membranoproliferative Glomerulonephritis:

id Genetic test Affiliating Genes
1 Mesangiocapillary Glomerulonephritis27
2 Membranoproliferative Glomerulonephritis27 24 PLA2R1

Anatomical Context for Membranoproliferative Glomerulonephritis

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MalaCards organs/tissues related to Membranoproliferative Glomerulonephritis:

36
Kidney, B cells, Liver, Thyroid, Lymph node, Myeloid, Lung

Publications for Membranoproliferative Glomerulonephritis

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Articles related to Membranoproliferative Glomerulonephritis:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Association of membranoproliferative glomerulonephritis with renal cell carcinoma. (28004485)
2017
2
SjAPgren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis. (27904866)
2016
3
Membranoproliferative Glomerulonephritis Secondary to a Low-Grade Lymphoproliferative Disorder: A Rare Cause of Renal Dysfunction. (27812262)
2016
4
Intravascular large B-cell lymphoma: masquerade as membranoproliferative glomerulonephritis. (27312458)
2016
5
Streptococcal Infection-related Nephritis (SIRN) Manifesting Membranoproliferative Glomerulonephritis Type I. (26984084)
2016
6
Anaerococcus urinomassiliensis sp. nov., isolated from a urine sample of a 17-year-old boy affected by autoimmune hepatitis and membranoproliferative glomerulonephritis. (27408746)
2016
7
Intestinal Intravascular Large B-cell Lymphoma Mimicking Ulcerative Colitis with Secondary Membranoproliferative Glomerulonephritis. (27580553)
2016
8
Differences in clinical findings, pathology, and outcomes between C3 glomerulonephritis and membranoproliferative glomerulonephritis. (26846787)
2016
9
Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN. (27458560)
2016
10
Multimodal imaging of membranoproliferative glomerulonephritis type II. (28003788)
2016
11
Coexistence of atypical hemolytic uremic syndrome with membranoproliferative glomerulonephritis and antineutrophil cytoplasmic antibodies-associated vasculitis. (27424702)
2016
12
Use of C4d as a diagnostic tool to classify membranoproliferative glomerulonephritis. (27595516)
2016
13
Successful Recovery of Acute Renal Transplant Failure in Recurrent Hepatitis C Virus-Associated Membranoproliferative Glomerulonephritis. (27778453)
2016
14
Understanding the complement-mediated glomerular diseases: focus on membranoproliferative glomerulonephritis and C3 glomerulopathies. (27356907)
2016
15
An unusual case of idiopathic crescentic membranoproliferative glomerulonephritis with posterior reversible encephalopathy syndrome. (27424710)
2016
16
An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report. (27439394)
2016
17
Membranoproliferative glomerulonephritis recurrence after kidney transplantation: using the new classification. (26754737)
2016
18
Membranoproliferative glomerulonephritis and acute renal failure in a patient with chronic lymphocytic leukemia: Response to obinutuzumab. (27352257)
2016
19
Manifestations of Complement-Mediated and Immune Complex-Mediated Membranoproliferative Glomerulonephritis: A Comparative Consecutive Series. (26996341)
2016
20
Novel factor H mutation associated with familial membranoproliferative glomerulonephritis type I. (26289290)
2015
21
Glomerular Diseases Dependent on Complement Activation, Including Atypical Hemolytic Uremic Syndrome, Membranoproliferative Glomerulonephritis, and C3 Glomerulopathy: Core Curriculum 2015. (26032627)
2015
22
Type of immune and complement deposits and response of immunosuppressive treatment on Membranoproliferative Glomerulonephritis -- a single centre experience. (26338748)
2015
23
Treatment-resistant recurrent membranoproliferative glomerulonephritis in renal allograft responding to rituximab: case report. (25891740)
2015
24
Immunoglobulin A dominant membranoproliferative glomerulonephritis in an elderly man: A case report and review of the literature. (26060367)
2015
25
A case of membranoproliferative glomerulonephritis associated with curved fibril deposition. (26370133)
2015
26
Successful treatment of hepatitis E virus-associated cryoglobulinemic membranoproliferative glomerulonephritis with ribavirin. (25708383)
2015
27
Polyarthritis and membranoproliferative glomerulonephritis as paraneoplastic manifestation of Hodgkin's lymphoma: A case report and literature review. (26654571)
2015
28
Clinicopathological features of membranoproliferative glomerulonephritis under a new classification. (26445002)
2015
29
Membranoproliferative glomerulonephritis in a puerperal with SjAPgren's syndrome: Rare finding or something else? (26306976)
2015
30
A Case of Cryoglobulinemic Membranoproliferative Glomerulonephritis Induced by Hepatitis C Virus. (26328796)
2015
31
Membranoproliferative glomerulonephritis with predominant IgG2 and IgG3 deposition in a patient with IgG4-related disease. (26502965)
2015
32
AJKD Atlas of Renal Pathology: Membranoproliferative Glomerulonephritis. (26300204)
2015
33
Disseminated strongyloidiasis in a patient with membranoproliferative glomerulonephritis-case report. (25904959)
2015
34
Renal interstitial mast cell count is significantly higher in membranoproliferative glomerulonephritis than in class IV lupus nephritis. (26247528)
2015
35
SHEDDING LIGHT ON FUNDUS DRUSEN ASSOCIATED WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS: BREAKING STEREOTYPES OF TYPES I, II, AND III. (26110522)
2015
36
The incidence of possible causes of membranoproliferative glomerulonephritis: a single-center experience. (27688695)
2015
37
Membranoproliferative glomerulonephritis with masked monotypic immunoglobulin deposits. (26154922)
2015
38
Membranoproliferative glomerulonephritis and C3 glomerulonephritis: Frequency, clinical features, and outcome in children. (25524631)
2015
39
Morphological changes in membranoproliferative glomerulonephritis - a quantitative approach. (26743276)
2015
40
Early rehabilitation of a child with intensive care unit acquired weakness secondary to membranoproliferative glomerulonephritis: A case report. (27186711)
2015
41
Membranoproliferative glomerulonephritis due to visceral leishmaniasis in an HIV patient. (25575099)
2015
42
Membranoproliferative glomerulonephritis, type II cryoglobulinemia and triple therapy for hepatitis C: a case series and review of the literature. (24633573)
2014
43
Treatment of choroidal neovascularisation secondary to membranoproliferative glomerulonephritis type II with intravitreal ranibizumab. (24895384)
2014
44
Rituximab in a B cell-driven regimen for the treatment of recurrent membranoproliferative glomerulonephritis after kidney transplantation. (25080208)
2014
45
Recombinant Human Erythropoietin (RHuEpo) and Granular Colony Stimulating Factor (G-CSF) in hepatitis C virus (HCV) related to mixed cryoglobulinaemia associated to membranoproliferative glomerulonephritis type I: a case report description. (25551853)
2014
46
Eculizumab in the Treatment of Membranoproliferative Glomerulonephritis. (25402185)
2014
47
Renal Pathology: SY23-1 CURRENT APPROACH TO CLASSIFICATION OF MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS. (25188169)
2014
48
IgA Nephropathy with Pathologic Features of Membranoproliferative Glomerulonephritis following Burn Injury. (24707281)
2014
49
Membranoproliferative glomerulonephritis associated with autoimmune diseases. (24500888)
2014
50
Splenic Marginal Zone Lymphoma and Concurrent Membranoproliferative Glomerulonephritis With IgMKappa Deposits in a HCV-Seropositive Patient. (25695019)
2014

Variations for Membranoproliferative Glomerulonephritis

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Expression for genes affiliated with Membranoproliferative Glomerulonephritis

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Search GEO for disease gene expression data for Membranoproliferative Glomerulonephritis.

Pathways for genes affiliated with Membranoproliferative Glomerulonephritis

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GO Terms for genes affiliated with Membranoproliferative Glomerulonephritis

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Cellular components related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.4ALB, C3, C4A, CFH
2endoplasmic reticulum lumenGO:00057889.4ALB, C3, C4A, CFP
3extracellular regionGO:00055767.9ALB, C3, C4A, CFH, CFHR5, CFP
4extracellular exosomeGO:00700627.8ALB, C3, C4A, CD46, CFH, ICAM1
5extracellular spaceGO:00056157.0ALB, C3, C4A, CFH, CFP, ICAM1

Biological processes related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of apoptotic cell clearanceGO:200042710.0C3, C4A
2complement activation, alternative pathwayGO:00069579.8C3, CFH, CFHR5, CFP
3cellular protein metabolic processGO:00442679.6ALB, C3, C4A
4complement activation, classical pathwayGO:00069589.6C3, C4A, CD46
5complement activationGO:00069569.5C3, C4A, CFH, CFP
6immune system processGO:00023769.2C3, C4A, CD46, CD79A
7innate immune responseGO:00450878.8C3, C4A, CD46, CFH, CFP
8regulation of complement activationGO:00304498.0C3, C4A, CD46, CFH, CFHR5, CFP

Molecular functions related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00048669.4C3, C4A

Sources for Membranoproliferative Glomerulonephritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet