MCID: MMB001
MIFTS: 51

Membranoproliferative Glomerulonephritis

Categories: Rare diseases, Nephrological diseases

Aliases & Classifications for Membranoproliferative Glomerulonephritis

MalaCards integrated aliases for Membranoproliferative Glomerulonephritis:

Name: Membranoproliferative Glomerulonephritis 12 49 36 28 14
Mesangiocapillary Glomerulonephritis 49 55 28
Primary Membranoproliferative Glomerulonephritis 49 55
Glomerulonephritis, Membranoproliferative 41 69
Mpgn 49 55
Glomerulonephritis Membranoproliferative 51
Chronic Glomerulonephritis, Lobular 12
Lobular Glomerulonephritis 12

Characteristics:

Orphanet epidemiological data:

55
primary membranoproliferative glomerulonephritis
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 55  
Rare renal diseases


External Ids:

Disease Ontology 12 DOID:2920
MeSH 41 D015432
NCIt 46 C34644
SNOMED-CT 64 80321008
Orphanet 55 ORPHA54370
MESH via Orphanet 42 D015432
UMLS via Orphanet 70 C0017662
ICD10 via Orphanet 33 N00.5
KEGG 36 H01726
UMLS 69 C0017662

Summaries for Membranoproliferative Glomerulonephritis

NIH Rare Diseases : 49 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 54370Disease definitionMembranoproliferative glomerulonephritis (MPGN) is a chronic progressive kidney disorder characterized by glomerular capillary wall structural changes and mesangial cell proliferation leading to nephrotic syndrome, hypocomplementemia, hypertension, proteinuria and end-stage kidney disease. MPGN can be due to either idiopathic (type 1, 2 and 3 MPGN; see these terms) or secondary (associated with infectious and immune complex diseases) causes.Visit the Orphanet disease page for more resources. Last updated: 2/29/2012

MalaCards based summary : Membranoproliferative Glomerulonephritis, also known as mesangiocapillary glomerulonephritis, is related to complement factor h deficiency and dense deposit disease. An important gene associated with Membranoproliferative Glomerulonephritis is CFH (Complement Factor H), and among its related pathways/superpathways are Complement and coagulation cascades and Influenza A. The drugs rituximab and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, b cells and liver, and related phenotypes are homeostasis/metabolism and normal

Wikipedia : 72 Membranoproliferative glomerulonephritis (\"MPGN\"), also known as mesangiocapillary glomerulonephritis,... more...

Related Diseases for Membranoproliferative Glomerulonephritis

Diseases related to Membranoproliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)
# Related Disease Score Top Affiliating Genes
1 complement factor h deficiency 33.0 CD46 CFH
2 dense deposit disease 33.0 C3 CFH CFHR5
3 c3 glomerulopathy 32.7 C3 CFHR5 CFP
4 hemolytic uremic syndrome, atypical 1 30.8 CFH CFHR5
5 cryoglobulinemia 30.6 CD79A TSLP
6 proliferative glomerulonephritis 30.3 C3 CD79A CFH
7 meningococcal meningitis 30.3 CFH CFP
8 acute poststreptococcal glomerulonephritis 30.2 CD79A CFP
9 membranous nephropathy 30.1 ALB CD79A NPHS1
10 microvascular complications of diabetes 3 30.0 ALB NPHS1
11 rapidly progressive glomerulonephritis 29.9 CD79A ICAM1
12 hemolytic-uremic syndrome 29.7 C3 CD46 CFH CFHR5
13 macular degeneration, age-related, 1 29.1 C3 CD46 CFH CFHR5
14 glomerulonephritis 29.0 ALB C3 C4A CD79A CFH CFHR5
15 thrombotic thrombocytopenic purpura 29.0 CD46 CFH
16 systemic lupus erythematosus 28.9 ALB C3 C4A CD79A ICAM1
17 membranoproliferative glomerulonephritis, x-linked 12.4
18 non-immunoglobulin-mediated membranoproliferative glomerulonephritis 12.3
19 dense deposit disease/membranoproliferative glomerulonephritis type ii 12.3
20 nephrotic syndrome, type 7 12.0
21 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 11.4
22 lipodystrophy, partial, acquired 11.3
23 complement component 3 deficiency, autosomal recessive 11.3
24 glomerulopathy with fibronectin deposits 2 11.1
25 lipodystrophy, partial, acquired, with low complement component c3, with or without glomerulonephritis 11.1
26 hypotrichosis-lymphedema-telangiectasia syndrome 11.1
27 hepatitis 10.7
28 hepatitis c 10.7
29 hepatitis c virus 10.6
30 retinal drusen 10.5 C3 CFH
31 blood group, i system 10.5
32 complement component 3 deficiency 10.4 C3 CFP
33 complement factor i deficiency 10.4 C3 CFP
34 acute maxillary sinusitis 10.4 C3 CD79A
35 arteriolosclerosis 10.4 C3 CD79A
36 anemia, autoimmune hemolytic 10.3 C3 CD79A
37 autoimmune disease of blood 10.3 C3 CD79A
38 cork-handlers' disease 10.3 ALB CD79A
39 ostertagiasis 10.3 ALB CD79A
40 dermatitis, atopic, 3 10.3 ALB CD79A
41 root caries 10.3 ALB CD79A
42 lymphoma 10.3
43 marasmus 10.3 ALB CD79A
44 gastrointestinal allergy 10.3 CD79A TSLP
45 parotitis 10.3 ALB CD79A
46 yellow nail syndrome 10.3 ALB CD79A
47 occupational dermatitis 10.3 ALB C3
48 chronic graft versus host disease 10.3 ALB CD79A
49 ascending cholangitis 10.3 ALB C3
50 focal dermal hypoplasia 10.3 ALB CD79A

Graphical network of the top 20 diseases related to Membranoproliferative Glomerulonephritis:



Diseases related to Membranoproliferative Glomerulonephritis

Symptoms & Phenotypes for Membranoproliferative Glomerulonephritis

MGI Mouse Phenotypes related to Membranoproliferative Glomerulonephritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.76 ALB C3 CD79A CFH CFP ICAM1
2 normal MP:0002873 9.43 ALB C3 CD79A CFH CFP NPHS1
3 renal/urinary system MP:0005367 9.02 ALB C3 CD79A CFH NPHS1

Drugs & Therapeutics for Membranoproliferative Glomerulonephritis

Drugs for Membranoproliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 3,Phase 1 174722-31-7 10201696
2
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
3 Antirheumatic Agents Phase 3,Phase 1
4 Antifungal Agents Phase 3
5 Anti-Infective Agents Phase 3
6 Calcineurin Inhibitors Phase 3
7 Cyclosporins Phase 3
8 Dermatologic Agents Phase 3
9 Immunosuppressive Agents Phase 3
10
Daratumumab Approved Phase 2 945721-28-8
11 Complement System Proteins Phase 2
12 Antigen-Antibody Complex Phase 2
13 Antibodies Phase 2
14 Antibodies, Monoclonal Phase 2
15 Immunoglobulins Phase 2
16
Aspirin Approved, Vet_approved Phase 1 50-78-2 2244
17 Angiotensin-Converting Enzyme Inhibitors Phase 1
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1
19 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Rituximab in Treatment of Membranoproliferative Glomerulonephritis Not yet recruiting NCT03180723 Phase 3 Rituximab;Cyclosporin
2 Eculizumab in Primary MPGN Completed NCT02093533 Phase 2 Eculizumab
3 A Proof-of-Mechanism Study to Determine the Effect of ACH-0144471 on C3 Levels in Patients With C3G or IC-MPGN Recruiting NCT03124368 Phase 2 ACH-0144471
4 Daratumumab in Treatment of PGNMID and C3 GN Recruiting NCT03095118 Phase 2 Daratumumab
5 Controlled Trial Evaluating Avacopan in C3 Glomerulopathy Recruiting NCT03301467 Phase 2 Avacopan;Avacopan Matching Placebo
6 Eculizumab Therapy for Dense Deposit Disease and C3 Nephropathy Unknown status NCT01221181 Phase 1 Eculizumab
7 Pilot Study of Rituximab for Membranoproliferative Glomerulonephritis Completed NCT00275613 Phase 1 Rituximab
8 Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease Terminated NCT01791686 Phase 1 CDX-1135
9 Sulodexide Treatment in Patients With Dense Deposit Disease Withdrawn NCT00583427 Phase 1 Sulodexide
10 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Recruiting NCT03201406

Search NIH Clinical Center for Membranoproliferative Glomerulonephritis

Cochrane evidence based reviews: glomerulonephritis, membranoproliferative

Genetic Tests for Membranoproliferative Glomerulonephritis

Genetic tests related to Membranoproliferative Glomerulonephritis:

# Genetic test Affiliating Genes
1 Mesangiocapillary Glomerulonephritis 28
2 Membranoproliferative Glomerulonephritis 28

Anatomical Context for Membranoproliferative Glomerulonephritis

MalaCards organs/tissues related to Membranoproliferative Glomerulonephritis:

38
Kidney, B Cells, Liver, Thyroid, Lymph Node, T Cells, Myeloid

Publications for Membranoproliferative Glomerulonephritis

Articles related to Membranoproliferative Glomerulonephritis:

(show top 50) (show all 576)
# Title Authors Year
1
Rituximab therapy for hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis. ( 29445495 )
2018
2
Membranoproliferative glomerulonephritis with unusual deposits of parallel arrangement striated structure: a new pathological entity?a8c. ( 29057733 )
2018
3
Membranoproliferative glomerulonephritis and interstitial nephritis in the setting of Epstein-Barr virus-related hemophagocytic syndromea8c. ( 29350173 )
2018
4
Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis andmuco-cutaneous lesions. ( 28950764 )
2017
5
Membranoproliferative Glomerulonephritis Associated with a Human Immunodeficiency Virus Infection. ( 28761237 )
2017
6
Clinical features and pathogenesis of membranoproliferative glomerulonephritis: a nationwide analysis of the Japan renal biopsy registry from 2007 to 2015. ( 29214407 )
2017
7
Rituximab for Treatment of Membranoproliferative Glomerulonephritis and C3 Glomerulopathies. ( 28573137 )
2017
8
Membranoproliferative glomerulonephritis associated with Rosai-Dorfman disease. ( 29043148 )
2017
9
Clinical and histological features of patients with membranoproliferative glomerulonephritis classified by immunofluorescence findings. ( 29319772 )
2017
10
Rare genetic variant in the CFB gene presenting as atypical hemolytic uremic syndrome and immune complex diffuse membranoproliferative glomerulonephritis, with crescents, successfully treated with eculizumab. ( 28210841 )
2017
11
Atypical antiglomerular basement membranes disease with nephrotic-range proteinuria, mesangial proliferation, and membranoproliferative glomerulonephritis pattern of injury. ( 29265053 )
2017
12
Hepatosplenic T-cell lymphoma associated with membranoproliferative glomerulonephritis. ( 28351190 )
2017
13
Retinal findings in membranoproliferative glomerulonephritis. ( 29260086 )
2017
14
A 61-Year-Old Man With Membranoproliferative Glomerulonephritis. ( 29169517 )
2017
15
Immune Complex Membranoproliferative Glomerulonephritis Associated with Transjugular Intrahepatic Portosystemic Shunts in Alcoholic Cirrhosis: Two Case Reports. ( 28226323 )
2017
16
A case of rapid amelioration of hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis treated by interferon-free directly acting antivirals for HCV in the absence of immunosuppressant. ( 28509128 )
2017
17
Daclatasvir/asunaprevir based direct-acting antiviral therapy ameliorate hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis: a case report. ( 28356063 )
2017
18
Atypical haemolytic uremic syndrome (aHUS) and membranoproliferative glomerulonephritis (MPGN), different diseases or a spectrum of complement-mediated glomerular diseases? ( 28798244 )
2017
19
Membranoproliferative Glomerulonephritis in Pregnancy. ( 28317619 )
2017
20
Association of membranoproliferative glomerulonephritis with renal cell carcinoma. ( 28004485 )
2017
21
Case Report of Spontaneous Remission of Biopsy-Proven Idiopathic Immune Complex-Mediated Membranoproliferative Glomerulonephritis. ( 28868298 )
2017
22
Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis. ( 28168280 )
2017
23
Differences in clinical findings, pathology, and outcomes between C3 glomerulonephritis and membranoproliferative glomerulonephritis. ( 26846787 )
2016
24
An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report. ( 27439394 )
2016
25
An unusual case of idiopathic crescentic membranoproliferative glomerulonephritis with posterior reversible encephalopathy syndrome. ( 27424710 )
2016
26
Manifestations of Complement-Mediated and Immune Complex-Mediated Membranoproliferative Glomerulonephritis: A Comparative Consecutive Series. ( 26996341 )
2016
27
Streptococcal Infection-related Nephritis (SIRN) Manifesting Membranoproliferative Glomerulonephritis Type I. ( 26984084 )
2016
28
Successful Recovery of Acute Renal Transplant Failure in Recurrent Hepatitis C Virus-Associated Membranoproliferative Glomerulonephritis. ( 27778453 )
2016
29
Membranoproliferative Glomerulonephritis Secondary to a Low-Grade Lymphoproliferative Disorder: A Rare Cause of Renal Dysfunction. ( 27812262 )
2016
30
Anaerococcus urinomassiliensis sp. nov., isolated from a urine sample of a 17-year-old boy affected by autoimmune hepatitis and membranoproliferative glomerulonephritis. ( 27408746 )
2016
31
Membranoproliferative glomerulonephritis recurrence after kidney transplantation: using the new classification. ( 26754737 )
2016
32
Coexistence of atypical hemolytic uremic syndrome with membranoproliferative glomerulonephritis and antineutrophil cytoplasmic antibodies-associated vasculitis. ( 27424702 )
2016
33
Understanding the complement-mediated glomerular diseases: focus on membranoproliferative glomerulonephritis and C3 glomerulopathies. ( 27356907 )
2016
34
Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN. ( 27458560 )
2016
35
Intestinal Intravascular Large B-cell Lymphoma Mimicking Ulcerative Colitis with Secondary Membranoproliferative Glomerulonephritis. ( 27580553 )
2016
36
Use of C4d as a diagnostic tool to classify membranoproliferative glomerulonephritis. ( 27595516 )
2016
37
Multimodal imaging of membranoproliferative glomerulonephritis type II. ( 28003788 )
2016
38
Membranoproliferative glomerulonephritis and acute renal failure in a patient with chronic lymphocytic leukemia: Response to obinutuzumab. ( 27352257 )
2016
39
Intravascular large B-cell lymphoma: masquerade as membranoproliferative glomerulonephritis. ( 27312458 )
2016
40
SjAPgren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis. ( 27904866 )
2016
41
Early rehabilitation of a child with intensive care unit acquired weakness secondary to membranoproliferative glomerulonephritis: A case report. ( 27186711 )
2015
42
The incidence of possible causes of membranoproliferative glomerulonephritis: a single-center experience. ( 27688695 )
2015
43
Disseminated strongyloidiasis in a patient with membranoproliferative glomerulonephritis-case report. ( 25904959 )
2015
44
Type of immune and complement deposits and response of immunosuppressive treatment on Membranoproliferative Glomerulonephritis -- a single centre experience. ( 26338748 )
2015
45
A case of membranoproliferative glomerulonephritis associated with curved fibril deposition. ( 26370133 )
2015
46
Membranoproliferative glomerulonephritis due to visceral leishmaniasis in an HIV patient. ( 25575099 )
2015
47
Glomerular Diseases Dependent on Complement Activation, Including Atypical Hemolytic Uremic Syndrome, Membranoproliferative Glomerulonephritis, and C3 Glomerulopathy: Core Curriculum 2015. ( 26032627 )
2015
48
Membranoproliferative glomerulonephritis and C3 glomerulonephritis: Frequency, clinical features, and outcome in children. ( 25524631 )
2015
49
Successful treatment of hepatitis E virus-associated cryoglobulinemic membranoproliferative glomerulonephritis with ribavirin. ( 25708383 )
2015
50
Immunoglobulin A dominant membranoproliferative glomerulonephritis in an elderly man: A case report and review of the literature. ( 26060367 )
2015

Variations for Membranoproliferative Glomerulonephritis

Expression for Membranoproliferative Glomerulonephritis

Search GEO for disease gene expression data for Membranoproliferative Glomerulonephritis.

Pathways for Membranoproliferative Glomerulonephritis

Pathways related to Membranoproliferative Glomerulonephritis according to KEGG:

36
# Name Kegg Source Accession
1 Complement and coagulation cascades hsa04610

GO Terms for Membranoproliferative Glomerulonephritis

Cellular components related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.87 ALB C3 C4A CD46 CFH ICAM1
2 extracellular region GO:0005576 9.8 ALB C3 C4A CFH CFHR5 CFP
3 extracellular space GO:0005615 9.5 ALB C3 C4A CFH CFP ICAM1
4 endoplasmic reticulum lumen GO:0005788 9.46 ALB C3 C4A CFP
5 blood microparticle GO:0072562 8.92 ALB C3 C4A CFH

Biological processes related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.73 C3 C4A CD46 CD79A
2 innate immune response GO:0045087 9.65 C3 C4A CD46 CFH CFP
3 cellular protein metabolic process GO:0044267 9.63 ALB C3 C4A
4 complement activation, classical pathway GO:0006958 9.54 C3 C4A CD46
5 complement activation GO:0006956 9.46 C3 C4A CFH CFP
6 positive regulation of interleukin-10 production GO:0032733 9.4 CD46 TSLP
7 positive regulation of apoptotic cell clearance GO:2000427 9.32 C3 C4A
8 complement activation, alternative pathway GO:0006957 9.26 C3 CFH CFHR5 CFP
9 regulation of complement activation GO:0030449 9.1 C3 C4A CD46 CFH CFHR5 CFP

Molecular functions related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.62 C3 C4A

Sources for Membranoproliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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