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MCID: MMB002

Membranous Glomerulonephritis malady
4 drugs, 36 genes, 2 tissues, 780 related diseases, 20 phenotypes, 23 articles, clinical trials.

Summaries for Membranous Glomerulonephritis

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44Wikipedia, 22MalaCards
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Wikipedia: Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly...44 more...

MalaCards: Membranous Glomerulonephritis, also known as idiopathic membranous nephropathy, is related to polycystic kidney disease and hypertension. An important gene associated with Membranous Glomerulonephritis is MME (membrane metallo-endopeptidase), and among its related pathways are Bacterial infections in CF airways and ACE Inhibitor Pathway, Pharmacodynamics. The drugs dopamine and albumin,human and the compounds glucose and pge2 have been mentioned in the context of this disorder. Affiliated tissues include kidney and endothelial, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Aliases & Descriptions for Membranous Glomerulonephritis

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6Disease Ontology, 7diseasecard, 30NIH Rare Diseases, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 24MeSH, 27NCIt
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Aliases & Descriptions:

membranous glomerulonephritis 6 7 30 8 43
idiopathic membranous nephropathy 30 32
membranous nephropathy 6 30
membranous glomerulonephritis (disorder) 6
extramembranous glomerulonephritis 30
glomerulonephritis, membranous 30
membranous nephropathy nos 6
nephropathy membranous 32
kidney diseases 43
membranous gn 30
mgn 30

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Related Diseases for Membranous Glomerulonephritis

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13GeneCards, 14GeneDecks
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Diseases related to membranous glomerulonephritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 777)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic kidney disease35.0LRP2, VEGFA, CLU, LAMB1, CD79A, ALB
2hypertension34.5NOS2, NOS3
3primary hyperoxaluria30.8LRP2, MPO, CD79A, ALB, ACE, HELT
4alport syndrome29.6LAMB1, CD79A, ALB, TGFB1
5chronic kidney failure29.0MTHFR, CD79A, ALB, CTSB, NOS3, ACE
6focal segmental glomerulosclerosis28.8CD79A, ALB, TRPC6, NOS2, ACE, AGTR1
7hyperparathyroidism28.6LRP2, VEGFA, ALB, TNF, NOS3, TGFB1
8nephrosis27.8LAMB1, MME, F9, ALB, TNF, ACE
9retinol binding protein27.8ALB, TNF, CTSB, ACE
10hypertensive nephropathy27.7ALB, ACE
11renal tubular dysgenesis27.6ACE, AGT, AGTR1
12congestive heart failure27.3MME, ACE, AGT, AGTR1
13aldosteronism27.3VEGFA, ALB, NOS2, NOS3, ACE, AGT
14hyperhomocysteinemia27.1MTHFR, F9, F5, ALB, NOS3, ACE
15obesity, association with27.0ALB, TNF, NOS3, ACE, TGFB1
16fatty liver disease27.0MTHFR, ALB, TNF, NOS2, ACE, AGTR1
17diabetes, type 226.7ALB, NOS3, ACE, AGT, AGTR1
18erythrocytosis26.7F5, NOS3, ACE, AGT, AGTR1
19marfan syndrome26.6MTHFR, F9, AGTR1, TGFB1
20renal cell carcinoma26.5VEGFA, CLU, CD59, MME, IFNG, AGTR1
21end stage renal failure26.4VEGFA, CD79A, ALB, TNF, NOS2, NOS3
22arterial calcification26.2ALB, TNF, NOS3, ACE, AGT
23type 2 diabetes mellitus26.2MTHFR, F9, ALB, CTSB, NOS3, ACE
24hemolytic-uremic syndrome26.2CLU, CD79A, ALB, TNF, TGFB1
25anemia26.0VEGFA, CLU, MTHFR, MPO, CD79A, CD59
26glomerulopathy26.0LRP2, CD79A, MME, F5, ALB, TRPC6
27fabry disease26.0MPO, F5, TNF, NOS3, ACE
28nephrosclerosis26.0MTHFR, MPO, ACE, AGTR1, TGFB1, SYNPO
29nephropathy25.9LRP2, VEGFA, CLU, MTHFR, LAMB1, MPO
30wilson disease25.9MTHFR, CD79A, F9, ALB, TNF, NOS2
31polycythemia25.9VEGFA, MPO, CD79A, ITGB2, F5, ACE
32hemophilia25.8MTHFR, IFNG, F9, F5, ALB, TNF
33iga glomerulonephritis25.6CD79A, CD55, ALB, ACE, AGT, AGTR1
34hepatitis b25.6IFNG, ALB, NOS3, TGFB1
35insulin resistance25.5VEGFA, CLU, MTHFR, MPO, IFNG, F9
36peptic ulcer25.5CD79A, IFNG, F5, ALB, TNF
37systemic lupus erythematosus25.4LRP2, CLU, LAMB1, MPO, CD79A, CD59
38hearing loss25.3LRP2, MTHFR, F5, TNF, NOS2, AGT
39crohn's disease25.3MPO, IFNG, TNF, NOS2
40irritable bowel syndrome25.0MPO, CD79A, IFNG, TNF, TGFB1
41obesity25.0VEGFA, CLU, MTHFR, MPO, CD79A, ITGB2
42bronchiectasis25.0MPO, CD79A, IFNG, ALB, TNF, NOS2
43appendicitis24.9MPO, CD79A, IFNG, ALB, TNF, PRKCA
44proteinuria24.7LRP2, VEGFA, CLU, MPO, CD79A, CD59
45cataract24.7VEGFA, MTHFR, ALB, TNF, ACE, TGFB1
46anorexia nervosa24.6LRP2, MME, IFNG, ALB, TNF, NOS2
47wilms tumor24.4VEGFA, MTHFR, MME, TNF, TGFB1, SYNPO
48uremia24.2IFNG, ALB, TNF, NOS2, NOS3, ACE
49diarrhea24.1VEGFA, MPO, CD79A, MME, IFNG, ALB
50ulcerative colitis24.0MPO, CD79A, CD59, CD55, ITGB2, ENO1

Graphical network of the top 20 diseases related to membranous glomerulonephritis:



Graphical network of diseases related to membranous glomerulonephritis

Clinical Features for Membranous Glomerulonephritis

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Drugs & Therapeutics for Membranous Glomerulonephritis

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for membranous glomerulonephritis

Drug clinical trials:

Search ClinicalTrials for membranous glomerulonephritis

Search NIH Clinical Center for membranous glomerulonephritis

Search CenterWatch for membranous glomerulonephritis

Inferred drug relations via UMLS/NDF-RT:

43 28 albumin,human, albumin,human inj [va product], dopamine, dopamine hydrochloride

Genetic Tests for Membranous Glomerulonephritis

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Anatomical Context for Membranous Glomerulonephritis

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22MalaCards
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MalaCards organs/tissues related to membranous glomerulonephritis:

22
Kidney, Endothelial

Phenotypes for genes affiliated with Membranous Glomerulonephritis

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25MGI
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MGI Mouse Phenotypes related to membranous glomerulonephritis:

25 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:000539710.6IL27RA
2endocrine/exocrine gland phenotypeMP:00053799.5LRP2, IFNG
3other phenotypeMP:00053959.2NOS3, NOS2, CTSB, MME, CLU
4skeleton phenotypeMP:00053909.0PECAM1, IL27RA, ITGB2, MTHFR, VEGFA, LRP2
5liver/biliary system phenotypeMP:00053708.9AGT, NOS3, F9, IFNG, IL27RA, VEGFA
6integument phenotypeMP:00107718.8CTSB, TRPC6, F5, IFNG, MME, ITGB2
7renal/urinary system phenotypeMP:00053678.8NPHS1, LRP2, CLU, CD55, IL27RA, CTSB
8nervous system phenotypeMP:00036318.4NPHS1, PRKCB, SYNPO, TGFB1, AGT, HELT
9adipose tissue phenotypeMP:00053758.0PRKCA, TGFB1, AGT, ACE, NOS3, NOS2
10growth/size phenotypeMP:00053788.0AGTR1, AGT, HELT, ACE, NOS3, CTSB
11digestive/alimentary phenotypeMP:00053817.8PECAM1, TGFB1, NOS3, NOS2, CTSB, IFNG
12immune system phenotypeMP:00053877.6PECAM1, PRKCB, AGTR1, PLA2R1, CTSB, TNF
13reproductive system phenotypeMP:00053897.4TGFB1, AGT, NOS2, TNF, IFNG, CD59
14behavior/neurological phenotypeMP:00053866.9ACE, HELT, AGT, SYNPO, PRKCB, NOS3
15vision/eye phenotypeMP:00053916.6TNF, NOS2, NOS3, TGFB1, TRPC6, IFNG
16muscle phenotypeMP:00053696.3NOS3, AGT, TGFB1, PRKCA, PECAM1, NOS2
17cellular phenotypeMP:00053846.1CTSB, NOS2, NOS3, ACE, TGFB1, PRKCB
18mortality/agingMP:00107685.8CTSB, NOS2, NOS3, ACE, HELT, AGT
19cardiovascular system phenotypeMP:00053855.1NOS3, ACE, AGT, AGTR1, TGFB1, PRKCB
20homeostasis/metabolism phenotypeMP:00053764.8TGFB1, PRKCB, PRKCA, NPHS1, PECAM1, AGT

Publications for genes affiliated with Membranous Glomerulonephritis

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35PubMed
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Articles related to membranous glomerulonephritis:

(show all 23)
idTitleAuthorsYearAffiliating Genes
1Direct characterization of target podocyte antigens a nd auto-antibodies in human membranous glomerulonephritis: Alfa-enolase and bor derline antigens. (21640210)Bruschi M.... Ghiggeri G.M.2011ENO1
2Lack of association between transient receptor potent ial cation channel 6 polymorphisms and primary membranous glomerulonephritis. (20540633)Chen W.C.... Chen Y.H.2010TRPC6
3Association between genetic polymorphisms of the NPHS 1 gene and membranous glomerulonephritis in the Taiwanese population. (20138859)Lo W.Y.... Tsai F.J.2010NPHS1
4Immunosuppressive treatment of idiopathic membranous glomerulonephritis with nephrotic syndrome (20088170)MuslimoviA8 A.... Uncanin S.2009ALB
5Arterial thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase C677T mutation in childhood membranous glomerulonephritis. (18030499)Buyukcelik M.... Balat A.2008F5, MTHFR
6Glomerular clusterin is associated with PKC-alpha/beta regulation and good outcome of membranous glomerulonephritis in humans. (16775601)Rastaldi M.P.... Ghiggeri G.M.2006PRKCA, CLU, PRKCB
7Tumor necrosis factor-alpha gene G-308A polymorphism is a risk factor for the development of membranous glomerulonephritis. (16391465)Bantis C.... Ivens K.2006TNF
8Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1). (16301622)Shimizu S.... Yoshida H.2005IFNG, IL27RA
9CD20-positive infiltrates in human membranous glomerulonephritis. (16013025)Cohen C.D.... Kretzler M.2005MS4A1
10IgA deficiency and membranous glomerulonephritis presenting as nephrotic syndrome. (15711951)Kawasaki Y.... Suzuki H.2005CD79A
11Interaction between gene polymorphisms of nitric oxide synthase and renin-angiotensin system in the progression of membranous glomerulonephritis. (14767013)Stratta P.... Matullo G.2004NOS3, ACE, AGTR1
12IgA deficiency with membranous glomerulonephritis: a case report and review. (12649548)Huang J.B.... Lin C.C.2003CD79A
13Decreased expression of vascular endothelial growth factor in idiopathic membranous glomerulonephritis: relationships to clinical course. (14655184)Honkanen E.... Gronhagen-Riska C.2003VEGFA
14Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis. (11796821)GrAPne H.J.... Malle E.2002MPO
15Increased susceptibility of decay-accelerating factor deficient mice to anti-glomerular basement membrane glomerulonephritis. (11509624)Sogabe H.... Song W.C.2001CD55
16Decreased urinary excretion of vascular endothelial growth factor in idiopathic membranous glomerulonephritis. (10844604)Honkanen E.O.... GrAPnhagen-Riska C.2000VEGFA
17Abnormal expression of glomerular basement membrane laminins in membranous glomerulonephritis. (11096140)Fischer E.... Rossert J.2000LAMB1, SYNPO
18Adhesion molecules and urinary tumor necrosis factor-alpha in idiopathic membranous glomerulonephritis. (9551397)Honkanen E.... GrAPnhagen-Riska C.1998ITGB2, PECAM1
19Urine activity of cathepsin B, collagenase and urine excretion of TGF-beta 1 and fibronectin in membranous glomerulonephritis. (9879598)Senatorski G.... BartA8omiejczyk I.1998CTSB, TGFB1
20Membranous glomerulonephritis and nephrosis post factor IX infusions in hemophilia B. (9811389)Dharnidharka V.R.... Harris H.W.1998F9
21Effects of FK506 on experimental membranous glomerulonephritis induced by cationized bovine serum albumin in rats. (9794552)Kobayashi M.... Koyama A.1998ALB
22Urinary transforming growth factor-beta 1 in membranous glomerulonephritis. (9430852)Honkanen E.... GrAPnhagen-Riska C.1997TGFB1
23Urinary excretion of protectin (CD59), complement SC5b-9 and cytokines in membranous glomerulonephritis. (7543624)Lehto T.... Meri S.1995CD59

Expression for genes affiliated with Membranous Glomerulonephritis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Membranous Glomerulonephritis

Pathways for genes affiliated with Membranous Glomerulonephritis

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41Thomson Reuters, 34PharmGKB, 10EMD Millipore, 20KEGG
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Pathways related to membranous glomerulonephritis according to GeneDecks:

(show all 31)
idPathwayScoreTop Affiliating Genes
1Bacterial infections in CF airways4110.5CTSB
2ACE Inhibitor Pathway, Pharmacodynamics3410.4MME, AGTR1
3Immune response Lectin Induced complement pathway1010.2ITGB2, CD55, CLU
4Immune response_Alternative complement pathway4110.0ITGB2, CD55, CD59, CLU
5Immune response Alternative complement pathway1010.0ITGB2, CD55, CD59, CLU
6Immune response_Lectin induced complement pathway4110.0ITGB2, CD55, CD59, CLU
7Renin-angiotensin system2010.0MME, ACE, AGT, AGTR1
8Immune response Classic complement pathway1010.0ITGB2, CD55, CD59, CLU
9Immune response_Classical complement pathway419.9ITGB2, CD55, CD59, CLU
10Development_Angiotensin signaling via beta-Arrestin419.8PRKCA, PRKCB, AGTR1, AGT
11Development VEGF signaling via VEGFR2 - generic cascades109.6VEGFA, NOS3, PRKCB, PRKCA
12Hematopoietic cell lineage209.6TNF, MME, CD55, CD59, MS4A1
13Complement and coagulation cascades209.6F5, F9, CD55, CD59
14VEGF Signaling Pathway349.6PRKCA, PRKCB, NOS3, VEGFA
15VEGF signaling pathway209.4VEGFA, NOS3, PRKCB, PRKCA
16Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics349.4TGFB1, AGTR1, AGT, ACE, NOS3, MME
17Amoebiasis209.2PRKCA, PRKCB, TGFB1, NOS2, ITGB2, LAMB1
18Development_VEGF signaling via VEGFR2 - generic cascades419.2PRKCA, PRKCB, NOS3, NOS2, VEGFA
19African trypanosomiasis208.9IFNG, TNF, PRKCB, PRKCA
20Malaria208.9PECAM1, TGFB1, TNF, IFNG, ITGB2
21Transcription Role of VDR in regulation of genes involved in osteoporosis108.8PRKCA, PRKCB, TNF, IFNG
22Calcium signaling pathway208.8PRKCA, PRKCB, AGTR1, NOS3, NOS2
23Rheumatoid arthritis208.7TGFB1, TNF, IFNG, ITGB2, VEGFA
24Pathways in cancer208.6PRKCA, PRKCB, TGFB1, NOS2, LAMB1, VEGFA
25Immune response_MIF-mediated glucocorticoid regulation418.6IFNG, TNF, NOS2
26Natural killer cell mediated cytotoxicity208.6ITGB2, IFNG, TNF, PRKCB, PRKCA
27Chagas disease (American trypanosomiasis)208.4TGFB1, ACE, NOS2, TNF, IFNG
28Toxoplasmosis208.4LAMB1, IFNG, TNF, NOS2, TGFB1
29Immune response MIF-mediated glucocorticoid regulation108.3IFNG, TNF, NOS2
30Tuberculosis208.3TGFB1, NOS2, PLA2R1, TNF, IFNG, ITGB2
31Leishmaniasis208.2PRKCB, TGFB1, NOS2, TNF, IFNG, ITGB2

Compounds for genes affiliated with Membranous Glomerulonephritis

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32Novoseek , 42Tocris Bioscience, 9DrugBank, 18HMDB, 34PharmGKB
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Compounds related to membranous glomerulonephritis according to GeneDecks:

(show top 50)    (show all 221)
idCompoundScoreTop Affiliating Genes
1glucose32 10.2NPHS1, MME, LAMB1, ENO1
2pge232 10.1CTSB, AGT, MME, PRKCB
3n acetylcysteine32 9.8AGT, PRKCA, CD79A, CLU
4apocynin32 9.8MPO, NOS2
5captopril32 42 9 9 12.6ACE, CD79A, ALB, AGT
6l-nmma32 9.5NOS2, AGT, AGTR1
7lisinopril32 9 18 9 12.4AGT, AGTR1, VEGFA, MME, ALB, ACE
8calcitriol32 42 9 18 9 13.2LRP2, CLU, PRKCA, PRKCB, ALB
9ramipril32 9 9 11.2TGFB1, AGTR1, ACE, ALB, CD79A
10benazepril32 9 9 11.1ACE, TGFB1, AGT, MTHFR, AGTR1
11h2o232 9.1MME, AGT, F9, CD79A, MPO, AGTR1
12perindopril32 34 9 9 11.9TGFB1, AGTR1, AGT, ACE, NOS3, ALB
13candesartan32 9 9 10.9VEGFA, TGFB1, ACE, NOS3, ALB, AGT
14histamine32 18 9.8PECAM1, ITGB2, MPO, CD79A, PRKCA, ALB
15ang ii32 8.7TGFB1, AGTR1, AGT, NOS2, ACE, VEGFA
16kininogen32 8.7ACE, CTSB, ALB, F5, F9, ITGB2
17glutamate32 8.6CTSB, CD79A, F9, ENO1, MME, ITGB2
18arginine32 8.6AGTR1, ENO1, NPHS1, AGT, NOS3, F5
19paraffin32 8.6AGT, TGFB1, PECAM1, CTSB, MME, CD79A
20atorvastatin32 34 9 18 9 12.4F5, TNF, AGT, NOS3, VEGFA, CD59
21fibrinogen32 8.4ITGB2, ENO1, ALB, CD79A, CLU, F5
22heparin32 9 18 9 11.3CTSB, AGT, CD79A, LRP2, ALB, F9
23aminoguanidine32 9 9 10.2AGTR1, ALB, IFNG, CLU, NOS2, NOS3
24diphenyleneiodonium32 8.2MPO, AGT, NOS3, NOS2, TNF, VEGFA
25estrogen32 8.2PRKCA, NOS2, NOS3, CTSB, F9, MTHFR
26sb 20358032 42 9.1AGTR1, VEGFA, AGT, ITGB2, TNF, IFNG
27paclitaxel32 34 9 9 11.0PRKCA, PRKCB, TGFB1, NOS3, F5, ITGB2
28taurine chloramine32 8.0F5, TNF, MPO, NOS2, IFNG
29oxygen32 18 9.0CLU, MPO, PECAM1, PRKCB, AGTR1, AGT
30prostacyclin32 7.9PECAM1, AGT, AGTR1, ACE, VEGFA, MME
31aspirin32 34 18 9.8ACE, CD79A, MTHFR, F5, AGTR1, TGFB1
32vitamin d32 7.7PRKCB, TGFB1, NOS3, ALB, ITGB2, AGTR1
33simvastatin32 34 42 9 18 9 12.7AGTR1, AGT, NPHS1, VEGFA, ITGB2, F5
34lactate32 7.6CTSB, CD59, ITGB2, MME, ENO1, F5
35cysteine32 7.4MTHFR, CTSB, AGT, AGTR1, PRKCA, CD55
36vegf32 7.4NPHS1, PRKCA, PRKCB, ITGB2, CD55, MPO
37superoxide32 18 8.4TNF, AGTR1, AGT, NOS3, NOS2, MPO
38thymidine32 18 8.2MME, MTHFR, CLU, F9, TNF, AGT
39calcium32 9 18 9 10.2AGTR1, NPHS1, PRKCB, CD59, PECAM1, AGT
40cholesterol32 9 18 9 10.0F9, ITGB2, CD55, CD59, MTHFR, LRP2
41lipid32 6.9F9, ALB, TRPC6, TNF, ITGB2, ENO1
42cycloheximide32 6.8VEGFA, IFNG, CLU, MME, CTSB, CD55
43actinomycin d32 6.8IFNG, CD55, MME, VEGFA, CLU, TNF
44creatinine32 6.7MTHFR, MPO, NPHS1, PRKCB, SYNPO, TGFB1
45dexamethasone32 42 34 9 9 10.5CTSB, NOS2, AGT, NPHS1, TGFB1, TNF
46cyclosporin a32 42 7.4TNF, CTSB, AGT, AGTR1, TGFB1, PRKCB
47indomethacin32 9 9 8.3TNF, ALB, IFNG, MME, ITGB2, CD79A
48nitric oxide32 9 18 9 8.8CTSB, NOS2, NOS3, ACE, AGT, AGTR1
49serine32 5.5LRP2, ENO1, CLU, MTHFR, MPO, CD55
50retinoic acid32 42 18 7.3CD79A, PECAM1, NPHS1, PRKCA, TGFB1, ITGB2

GO Terms for genes affiliated with Membranous Glomerulonephritis

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12Gene Ontology
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Cellular components related to membranous glomerulonephritis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.1TGFB1, ALB, F5, CLU, VEGFA
2membrane raftGO:0451219.0NPHS1, PRKCA, TNF, CD55, CD79A
3cell surfaceGO:0099868.8VEGFA, CD59, CD55, TNF, PLA2R1, TGFB1
4external side of plasma membraneGO:0098978.2ACE, CTSB, TNF, IFNG, CD79A
5extracellular regionGO:0055767.1TGFB1, AGT, PLA2R1, ALB, F5, F9
6extracellular spaceGO:0056156.3LRP2, PECAM1, TGFB1, AGT, ACE, CTSB
7plasma membraneGO:0058866.0TNF, PLA2R1, NOS3, ACE, AGTR1, PRKCB

Biological processes related to membranous glomerulonephritis according to GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1regulation of renal output by angiotensinGO:00201910.4ACE, AGT
2positive regulation of NAD(P)H oxidase activityGO:03386410.3AGTR1, AGT
3histone H3-T6 phosphorylationGO:03540810.3PRKCA, PRKCB
4cellular response to carbohydrate stimulusGO:07132210.3PRKCB, PRKCA
5mononuclear cell proliferationGO:03294310.2ACE, TGFB1
6regulation of blood vessel size by renin-angiotensinGO:00203410.1AGTR1, AGT
7regulation of vasoconstrictionGO:01922910.1AGTR1, AGT, ACE
8B cell activationGO:04211310.1PRKCB, CD79A, MS4A1
9renin-angiotensin regulation of aldosterone productionGO:00201810.1AGTR1, AGT
10positive regulation of cellular protein metabolic processGO:03227010.1TGFB1, AGTR1, AGT
11positive regulation of blood vessel endothelial cell migrationGO:04353610.1VEGFA, TGFB1, PRKCA
12positive regulation of endothelial cell migrationGO:01059510.0PRKCA, AGT, VEGFA
13kidney developmentGO:00182210.0AGTR1, AGT, ACE, MME
14regulation of renal sodium excretionGO:03581310.0AGT, AGTR1
15low-density lipoprotein particle remodelingGO:0343749.9MPO, AGT, AGTR1
16blood vessel remodelingGO:0019749.9NOS3, AGT
17positive regulation of protein complex assemblyGO:0313349.8VEGFA, TNF, TGFB1
18positive regulation of angiogenesisGO:0457669.6VEGFA, NOS3, PRKCB, PRKCA
19regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.6ACE, AGTR1
20agingGO:0075689.6PRKCA, TGFB1, AGT, NOS3, LRP2
21response to mechanical stimulusGO:0096129.6TNF, CTSB, NOS3, PRKCA
22lipopolysaccharide-mediated signaling pathwayGO:0316639.5TGFB1, NOS3, TNF
23positive regulation of vitamin D biosynthetic processGO:0605579.5IFNG, TNF
24positive regulation of protein phosphorylationGO:0019349.4VEGFA, TNF, TGFB1, PRKCA
25positive regulation of NF-kappaB transcription factor activityGO:0510929.4PRKCB, TGFB1, AGT, TNF, CLU
26positive regulation of calcidiol 1-monooxygenase activityGO:0605599.3TNF, IFNG
27positive regulation of killing of cells of other organismGO:0517129.3NOS2, IFNG
28platelet degranulationGO:0025769.3PECAM1, TGFB1, ALB, F5, CLU, VEGFA
29positive regulation of cell adhesionGO:0457859.2PRKCA, IFNG, VEGFA
30neutrophil chemotaxisGO:0305939.2PRKCA, IFNG, ITGB2
31protein import into nucleus, translocationGO:0000609.1TGFB1, TNF, IFNG
32response to hypoxiaGO:0016668.9TGFB1, NOS3, NOS2, TNF, VEGFA
33negative regulation of transcription from RNA polymerase II promoterGO:0001228.7TGFB1, HELT, HBE1, TNF, IFNG, ENO1
34regulation of insulin secretionGO:0507968.7IFNG, TNF, NOS2, PRKCA
35platelet activationGO:0301688.5PECAM1, PRKCA, PRKCB, TGFB1, TRPC6, ALB
36blood coagulationGO:0075967.0VEGFA, PECAM1, PRKCA, PRKCB, TGFB1, HBE1

Molecular functions related to membranous glomerulonephritis according to GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1histone kinase activity (H3-T6 specific)GO:03540310.1PRKCA, PRKCB
2bradykinin receptor bindingGO:03171110.0AGTR1, ACE
3acetyltransferase activator activityGO:01069810.0AGTR1, AGT
4arginine bindingGO:0346189.6NOS2, NOS3
5nitric-oxide synthase activityGO:0045179.5NOS2, NOS3
6tetrahydrobiopterin bindingGO:0346179.3NOS2, NOS3
7protein bindingGO:0055155.3LRP2, NOS3, ACE, AGTR1, TGFB1, SYNPO

Sources for Membranous Glomerulonephritis

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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