MCID: MMB002
MIFTS: 60

Membranous Glomerulonephritis malady

Nephrological diseases category

Summaries for Membranous Glomerulonephritis

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly... more...

MalaCards: Membranous Glomerulonephritis, also known as membranous nephropathy, is related to glomerulonephritis and hepatitis. An important gene associated with Membranous Glomerulonephritis is MBNP (?Membranous nephropathy, susceptibility to), and among its related pathways is Immune response Lectin induced complement pathway. The compounds glutamate and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone marrow and t cells, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Description from OMIM:46 614692

Aliases & Classifications for Membranous Glomerulonephritis

About this section
Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

membranous glomerulonephritis 8 42 10 60
membranous nephropathy 8 42 46
idiopathic membranous glomerulonephritis 48 60
idiopathic membranous nephropathy 42 44
membranous nephropathy, susceptibility to 9
extramembranous glomerulonephritis 42
glomerulonephritis, membranous 42
membranous nephropathy nos 8
nephropathy membranous 44
membranous gn 42


External Ids:

Disease Ontology8 DOID:10976
NCIt39 C34645
SNOMED-CT56 197710000, 77182004
MeSH34 D015433
OMIM46 614692

Related Diseases for Membranous Glomerulonephritis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Membranous Glomerulonephritis family:

Membranous Congenital Glomerulonephritis Due to Anti-Maternal Neutral Endopeptidase Alloimmunization

Diseases related to Membranous Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.9PECAM1, NPHS1, ITGB2, MPO, SYNPO, AGTR1
2hepatitis31.1HBE1, F9
3hepatitis b31.0F9, CTSB, CD79A, HBE1
4nephrotic syndrome30.9F9, NPHS1, SYNPO, AGT, TRPC6, CD79A
5lupus erythematosus30.7CD79A
6iga glomerulonephritis30.7NPHS1, AGTR1, AGT, CD79A
7systemic lupus erythematosus30.7ITGB2, MPO, CD79A, CD59, CLU, LAMB1
8hepatitis c30.6ENO1, CTSB, F9
9arthritis30.6CTSB, ITGB2, MPO, AGTR1, CD59, CLU
10rheumatoid arthritis30.5CTSB, ITGB2, MPO, CD79A, CD59, CLU
11hepatitis a30.5HBE1
12proteinuria30.5SYNPO, MPO, ITGB2, NPHS1, AGTR1, AGT
13myeloma30.4CD79A, ITGB2
14focal segmental glomerulosclerosis30.4NPHS1, AGTR1, AGT, TRPC6, CD79A
15purpura30.3CD79A
16proliferative glomerulonephritis30.3CD79A
17vasculitis30.3ENO1, CD79A, MPO, ITGB2
18pancreatitis30.1MPO, CTSB
19diabetes mellitus30.1NPHS1, ITGB2, AGTR1, AGT, CD79A, PECAM1
20ulcerative colitis30.1ITGB2, MPO, CD79A, CD59, ENO1, PECAM1
21leukemia30.1F9, ITGB2, MPO, CD79A, CD59, ENO1
22adenocarcinoma30.1CTSB, ITGB2, AGTR1, CD59, CLU, LAMB1
23thyroiditis29.9CD79A
24dermatitis29.9ITGB2, CD79A
25liver cirrhosis29.9AGT, HBE1
26prostatitis29.9CD79A
27thrombocytopenia29.9F9, CD79A, PECAM1
28membranoproliferative glomerulonephritis29.9CD79A, NPHS1
29peritonitis29.9ITGB2, MPO, PECAM1
30hypertension29.9CD79A, AGT, AGTR1
31macroglobulinemia29.9CD79A
32pneumonia29.9CD79A, MPO, CTSB
33diabetic nephropathy29.9AGT, AGTR1, SYNPO, NPHS1
34colon cancer29.9CLU, CD59, CTSB
35graves' disease29.9ITGB2, MPO, CD59
36melanoma29.9PECAM1, ENO1, CD59, CTSB
37prostate cancer29.9CTSB, SYNPO, AGTR1, TRPC6, CD59, CLU
38alport syndrome and thin basement membrane nephropathy10.5
39crescentic glomerulonephritis10.5
40immune-complex glomerulonephritis10.5
41alport syndrome10.5
42diffuse glomerulonephritis10.4
43thin basement membrane nephropathy10.4
44primary biliary cirrhosis10.4
45focal glomerulosclerosis10.4
46kidney disease10.3
47hepatitis e10.3
48multiple myeloma10.3
49lipoid nephrosis10.2
50ankylosing spondylitis10.2

Graphical network of the top 20 diseases related to Membranous Glomerulonephritis:



Diseases related to membranous glomerulonephritis

Clinical Features for Membranous Glomerulonephritis

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

614692

Drugs & Therapeutics for Membranous Glomerulonephritis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Membranous Glomerulonephritis

Drug clinical trials:

Search ClinicalTrials for Membranous Glomerulonephritis

Search NIH Clinical Center for Membranous Glomerulonephritis

Search CenterWatch for Membranous Glomerulonephritis

Genetic Tests for Membranous Glomerulonephritis

About this section

Anatomical Context for Membranous Glomerulonephritis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Membranous Glomerulonephritis:

32
Kidney, Bone marrow, T cells, Liver, Endothelial, Bone, B cells, Skin, Testes, Thyroid, Pancreas, Lung, Lymph node, Spleen, Colon, Smooth muscle, Heart, Cortex

Animal Models for Membranous Glomerulonephritis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Membranous Glomerulonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.4ITGB2, MPO, CD79A, CD59, IL27RA, MS4A1
2MP:00053679.2PECAM1, NPHS1, CTSB, SYNPO, AGTR1, AGT
3MP:00053859.0F9, ITGB2, MPO, AGTR1, AGT, TRPC6
4MP:00053878.9F9, CTSB, ITGB2, MPO, AGTR1, AGT
5MP:00053768.6MPO, ITGB2, CTSB, NPHS1, F9, AGTR1

Publications for Membranous Glomerulonephritis

About this section
Sources:
50PubMed
See all sources

Articles related to Membranous Glomerulonephritis:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Therapeutic effects of human mesenchymal stem cells in Wistar-Kyoto rats with anti-glomerular basement membrane glomerulonephritis. (23826305)
2013
2
Membranous glomerulonephritis associated with splenic marginal zone lymphoma mimicking multiple myeloma. (23725648)
2013
3
Beraprost sodium improves survival rates in anti-glomerular basement membrane glomerulonephritis and 5/6 nephrectomized chronic kidney disease rats. (23911885)
2013
4
Recurrence of paraneoplastic membranous glomerulonephritis following chemoradiation in a man with non-small-cell lung carcinoma. (23888216)
2013
5
An unusual cause of membranous glomerulonephritis in a patient with HIV. (21437594)
2012
6
Anti-glomerular basement membrane glomerulonephritis complicated by thrombocytopenia. (23257527)
2012
7
Anti-glomerular basement membrane glomerulonephritis with subsequent pulmonary hemorrhage in the course of pulmonary tuberculosis. (22950833)
2012
8
Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A(2) receptor antibody-positive membranous nephropathy. (22833809)
2012
9
Remission of membranous glomerulonephritis after pancreatectomy for pancreatic neuroendocrine neoplasm - a rare coincidence. (21269593)
2011
10
Membranous glomerulonephritis in a patient with syphilis. (21629349)
2011
11
Comment on 'Membranous glomerulonephritis secondary to Borrelia burgdorferi infection presenting as nephrotic syndrome'. (20147284)
2010
12
Pulmonary embolism revealing idiopathic membranous glomerulonephritis. (20886026)
2010
13
Hepatitis C virus infection was not found in patients with sporadic porphyria cutanea tarda, membranoproliferative glomerulonephritis or membranous glomerulonephritis in Northern Norway. (19266396)
2009
14
Glomerular morphometry in biopsy evaluation of minimal change disease, membranous glomerulonephritis, thin basement membrane disease and Alport's syndrome. (17672378)
2007
15
A case with membranous lupus nephritis developing after a twenty-year remission of membranoproliferative glomerulonephritis. (16702746)
2006
16
Membranous glomerulonephritis with monoclonal immune deposits and crescents. (15956059)
2005
17
Thrombotic thrombocytopenic purpura complicating SjAPgren's syndrome with crescentic glomerulonephritis and membranous nephritis. (17143670)
2004
18
Pregnancy in membranous glomerulonephritis--course, treatment and outcome. (14964459)
2004
19
Fc receptor-mediated accumulation of macrophages in crescentic glomerulonephritis induced by anti-glomerular basement membrane antibody administration in WKY rats. (15096492)
2004
20
Inflammatory demyelinating polyradiculoneuropathy associated with membranous glomerulonephritis and thrombocytopaenia. (12445919)
2002
21
Idiopathic membranous glomerulonephritis. (11318974)
2001
22
Choroidal tuberculoma with membranous glomerulonephritis. (11519089)
2001
23
Membranous glomerulonephritis associated with diffuse malignant pleural mesothelioma: report of a case. (11193748)
2000
24
Rhinocerebral mucormycosis in a patient with membranous glomerulonephritis. (11096298)
2000
25
Membranous Glomerulonephritis in a Patient Presenting with Chyluria, Probably due to Filariasis: How far should we investigate? (18212428)
1999
26
Disseminated cutaneous plasmacellular granuloma associated with membranous glomerulonephritis. (10344377)
1999
27
MPO antibody-positive vasculitis in a patient with psoriatic arthritis and gold-induced membranous glomerulonephritis. (9719174)
1998
28
A case of membranous glomerulonephritis associated with gastric cancer. (9343999)
1997
29
IgG subclasses in patients with membranoproliferative glomerulonephritis, membranous nephropathy, and lupus nephritis. (8995742)
1997
30
Hepatitis C virus associated membranous glomerulonephritis. (8556829)
1995
31
Factors contributing to the outcome in 100 adult patients with idiopathic membranous glomerulonephritis. (8026929)
1994
32
HLA associations in end-stage renal disease due to membranous glomerulonephritis: HLA-DR3 associations with progressive renal injury. Southeastern Organ Procurement Foundation. (8203361)
1994
33
Dysfunction of glomerular fibrinolysis in experimental antiglomerular basement membrane antibody glomerulonephritis. (8329670)
1993
34
Long-term benefits of therapy with cyclophosphamide and prednisone in patients with membranous glomerulonephritis and impaired renal function. (1739084)
1992
35
Hepatitis C virus infection and membranous glomerulonephritis. (1956497)
1991
36
The pathogenesis of membranous glomerulonephritis: from morphology to molecules. (1970689)
1990
37
Membranous glomerulonephritis in diabetic patients: a study of 15 cases and review of the literature. (2408036)
1990
38
A controlled trial of cyclophosphamide in patients with membranous glomerulonephritis. (3323596)
1987
39
Reversible membranous glomerulonephritis associated with ketoprofen. (3780072)
1986
40
Membranous glomerulonephritis in Hong Kong. (6465947)
1984
41
Membranous glomerulonephritis associated with industrial mercury exposure. Study of pathogenetic mechanisms. (7041618)
1982
42
Membranous glomerulonephritis in renal transplant. A case report and review of the literature. (6762093)
1982
43
Idiopathic membranous glomerulonephritis with crescents. (7020333)
1981
44
Transformation of diffuse proliferative glomerulonephritis to membranous nephritis in a patient with systemic lupus erythematosus. (7266728)
1981
45
Membranous glomerulonephritis in renal allografts. (6988721)
1980
46
Juvenile cirrhosis and membranous glomerulonephritis in a child with alpha1-antitrypsin deficiency PiSZ. (309702)
1978
47
Change from diffuse proliferative to membranous glomerulonephritis: serial biopsies in four cases. (4591751)
1974
48
The relationship of neutrophilic and eosinophilic leukocytes to the glomerular capillary basement membrane in acute proliferative glomerulonephritis. (5136992)
1971
49
Membranous glomerulonephritis. (4185598)
1969
50
Membranous glomerulonephritis: rapidly fatal course. (6045476)
1967

Genetic Variations for Membranous Glomerulonephritis

About this section

Expression for genes affiliated with Membranous Glomerulonephritis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Membranous Glomerulonephritis

Search GEO for disease gene expression data for Membranous Glomerulonephritis.

Pathways for genes affiliated with Membranous Glomerulonephritis

About this section
Sources:
12EMD Millipore, 53Reactome
See all sources

Pathways related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Lectin induced complement pathway
Hide members
10.1CLU, CD59, ITGB2

Compounds for genes affiliated with Membranous Glomerulonephritis

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
See all sources

Compounds related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1glutamate4410.6AGTR1, ITGB2
2cyclophosphamide44 49 1112.6ITGB2, MS4A1
3polyurethane4410.5PECAM1, ITGB2
4cv 119744410.5AGT, AGTR1
5silicone4410.4CD79A, F9, ITGB2
6indomethacin44 59 28 1113.4CTSB, AGT, NPHS1
7chymotrypsinogen4410.4CTSB, F9
8cgp42112a4410.4AGTR1, AGT
9aliskiren44 1111.4AGTR1, AGT
10rituximab44 49 1112.4CD59, MS4A1, F9, CD79A
11kininogen4410.3ITGB2, CLU, CTSB, F9
12captopril44 28 49 59 1114.3CD79A, AGT, AGTR1
13superoxide44 2411.3AGTR1, ENO1, CD59, AGT
14prednisolone44 28 1112.3CD79A, F9, ITGB2, MPO
15methacholine44 1111.3MPO, CD79A, AGTR1
16simvastatin44 49 59 28 11 2415.2AGT, NPHS1, ITGB2, AGTR1
17sialic acid4410.2CD59, CD79A, PECAM1, CLU, F9
18deoxyribonucleic acid4410.2CLU, AGTR1, AGT
19ivig4410.2ITGB2, CD79A, F9
20glucose4410.2CTSB, AGTR1, AGT, CD59, NPHS1
21isoproterenol44 1111.1AGT, AGTR1, ITGB2, CTSB
22cyclosporin a44 28 5912.1ITGB2, CD79A, CD59, PECAM1, F9, CTSB
23ethanol44 49 11 2413.1CLU, AGTR1, ITGB2, CTSB, F9
24sucrose44 11 2412.1F9, AGTR1, AGT, CD59
25n acetylcysteine4410.1AGT, CD79A, CLU, MPO, AGTR1
26actinomycin d4410.1PECAM1, CLU, AGT, AGTR1, CTSB
27dexamethasone44 49 28 1113.0CD79A, CLU, AGT, F9, NPHS1, ITGB2
28saralasin4410.0AGTR1, AGT
29oxygen44 2411.0MPO, PECAM1, AGT, CD59, CLU, CTSB
30aspirin44 49 28 2413.0CD79A, CD59, PECAM1, AGTR1
31phenylephrine44 28 11 2413.0TRPC6, AGT, AGTR1
32paraffin449.9MS4A1, CLU, AGT, MPO, CTSB, PECAM1
33cerulein449.8CTSB, MPO
34lactate449.8ENO1, CLU, CTSB, CD59, CD79A, MPO
35atp44 2810.8CLU, PECAM1, AGTR1, ITGB2, AGT, CD59
36thymidine44 2410.8PECAM1, F9, CTSB, AGT, CLU
37heparin44 28 11 2412.8PECAM1, F9, CTSB, ITGB2, AGT, MPO
38cholesterol44 28 11 2412.7CD59, AGTR1, ITGB2, CTSB, F9, CLU
39nitric oxide44 11 2411.7MPO, ITGB2, CTSB, AGTR1, AGT, PECAM1
40arginine449.7F9, NPHS1, CTSB, ITGB2, ENO1, AGTR1
41fibrinogen449.6CD79A, CTSB, ITGB2, PECAM1, ENO1, AGTR1
42retinoic acid44 2410.6ITGB2, MPO, CD79A, CLU, ENO1, CTSB
43h2o2449.6F9, CTSB, ITGB2, MPO, PECAM1, CLU
44vegf449.6NPHS1, ITGB2, MPO, AGTR1, AGT, CLU
45tyrosine449.6NPHS1, F9, CLU, CTSB, ITGB2, AGTR1
46cysteine449.6CD79A, PECAM1, ENO1, CLU, AGTR1, F9
47serine449.6ITGB2, CTSB, NPHS1, MPO, AGTR1, AGT
48creatinine449.5F9, ENO1, CD79A, AGT, AGTR1, NPHS1
49lipid449.4ITGB2, AGTR1, AGT, NPHS1, F9, ENO1
50calcium44 49 11 2412.1CTSB, AGT, F9, TRPC6, PECAM1, ENO1

GO Terms for genes affiliated with Membranous Glomerulonephritis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:03605710.2TRPC6, NPHS1
2extracellular spaceGO:0056159.3PECAM1, CTSB, MPO, AGT, CD59, CLU
3plasma membraneGO:0058868.7F9, NPHS1, ITGB2, SYNPO, AGTR1, TRPC6

Biological processes related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.3AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.3AGTR1, AGT
3renin-angiotensin regulation of aldosterone productionGO:00201810.2AGT, AGTR1
4low-density lipoprotein particle remodelingGO:03437410.1AGT, AGTR1, MPO
5regulation of renal sodium excretionGO:03581310.1AGT, AGTR1
6positive regulation of macrophage derived foam cell differentiationGO:01074410.1AGT, AGTR1
7positive regulation of cholesterol esterificationGO:01087310.0AGTR1, AGT
8positive regulation of cellular protein metabolic processGO:0322709.8AGT, AGTR1
9blood coagulationGO:0075969.8PECAM1, F9, ITGB2, TRPC6, CD59, HBE1

Molecular functions related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activator activityGO:01069810.1AGT, AGTR1

Products for genes affiliated with Membranous Glomerulonephritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Membranous Glomerulonephritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet