MCID: MMB002
MIFTS: 56

Membranous Glomerulonephritis malady

Nephrological category

Summaries for Membranous Glomerulonephritis

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly... more...

MalaCards: Membranous Glomerulonephritis, also known as membranous nephropathy, is related to hepatitis c and hepatitis a. An important gene associated with Membranous Glomerulonephritis is MBNP (?Membranous nephropathy, susceptibility to), and among its related pathways is Immune response Lectin induced complement pathway. The compounds glutamate and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and kidney, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Description from OMIM:47 614692

Aliases & Classifications for Membranous Glomerulonephritis

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

membranous glomerulonephritis 8 43 10 61
membranous nephropathy 8 43 47
idiopathic membranous glomerulonephritis 49 61
idiopathic membranous nephropathy 43 45
membranous nephropathy, susceptibility to 9
extramembranous glomerulonephritis 43
glomerulonephritis, membranous 43
membranous nephropathy nos 8
nephropathy membranous 45
membranous gn 43


External Ids:

Disease Ontology8 DOID:10976
NCIt40 C34645
SNOMED-CT57 197710000, 77182004
MeSH35 D015433
OMIM47 614692

Related Diseases for Membranous Glomerulonephritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Membranous Glomerulonephritis family:

membranous congenital glomerulonephritis due to anti-maternal neutral endopeptidase alloimmunization

Diseases related to Membranous Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c30.9ENO1, CTSB, F9
2hepatitis a30.9HBE1
3systemic lupus erythematosus30.7ITGB2, MPO, CD79A, CD59, CLU, LAMB1
4arthritis30.6CTSB, ITGB2, MPO, AGTR1, CD59, CLU
5nephritis30.6NPHS1, MPO, CD79A
6nephrosis30.4NPHS1
7focal segmental glomerulosclerosis30.4NPHS1, AGTR1, AGT, TRPC6, CD79A
8proliferative glomerulonephritis30.3CD79A
9vasculitis30.3ENO1, CD79A, MPO, ITGB2
10ulcerative colitis30.2ITGB2, MPO, CD79A, CD59, ENO1, PECAM1
11adenocarcinoma30.2CTSB, ITGB2, AGTR1, CD59, CLU, LAMB1
12lupus nephritis30.0CD79A, ITGB2
13goodpasture syndrome30.0MPO
14thrombocytopenia30.0F9, CD79A, PECAM1
15membranoproliferative glomerulonephritis30.0CD79A, NPHS1
16hepatitis b30.0F9, CTSB, CD79A, HBE1
17thyroiditis30.0CD79A
18diabetic nephropathy30.0AGT, AGTR1, SYNPO, NPHS1
19sinusitis30.0CD79A
20macroglobulinemia30.0CD79A
21graves' disease30.0ITGB2, MPO, CD59
22thin basement membrane nephropathy10.9
23anti-basement membrane glomerulonephritis10.6
24n syndrome10.6
25immune-complex glomerulonephritis10.5
26crescentic glomerulonephritis10.4
27primary biliary cirrhosis10.4
28focal glomerulosclerosis10.4
29hepatitis c virus10.4
30membranous glomerulonephritis, antenatal10.3
31lipoid nephrosis10.2
32ankylosing spondylitis10.2
33hepatitis d10.2
34spondylitis10.2
35syphilis10.2
36guillain-barr� syndrome10.2
37alport syndrome and thin basement membrane nephropathy10.2
38retroperitoneal fibrosis10.2
39neurofibromatosis10.1
40antiphospholipid syndrome10.1
41small cell carcinoma10.1
42autoimmune hepatitis10.1
43kaposi's sarcoma10.1
44chronic inflammatory demyelinating polyradiculoneuropathy10.1
45nodular regenerative hyperplasia10.1
46fanconi syndrome10.1
47adult syndrome10.1
48aplastic anemia10.1
49chylous ascites10.1
50graft versus host disease10.0

Graphical network of the top 20 diseases related to Membranous Glomerulonephritis:



Diseases related to membranous glomerulonephritis

Clinical Features for Membranous Glomerulonephritis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

614692

Drugs & Therapeutics for Membranous Glomerulonephritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Membranous Glomerulonephritis

Drug clinical trials:

Search ClinicalTrials for Membranous Glomerulonephritis

Search NIH Clinical Center for Membranous Glomerulonephritis

Search CenterWatch for Membranous Glomerulonephritis

Genetic Tests for Membranous Glomerulonephritis

Anatomical Context for Membranous Glomerulonephritis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Membranous Glomerulonephritis:

33
Skin, Liver, Kidney, Lymph node, Lung, Spleen, Bone marrow, Whole blood, Cortex, Heart, Smooth muscle, Colon, Pancreas, Thyroid, T cells, B cells, Endothelial, Adrenal cortex

Animal Models for Membranous Glomerulonephritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Membranous Glomerulonephritis

Sources:
51PubMed
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Articles related to Membranous Glomerulonephritis:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Skimmin, a Coumarin from Hydrangea paniculata, Slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition. (23990847)
2013
2
A case of myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated glomerulonephritis and concurrent membranous nephropathy. (23537120)
2013
3
Membranous glomerulonephritis associated with Mycobacterium shimoidei pulmonary infection. (24367720)
2013
4
EBV-positive diffuse large B-cell lymphoma in a patient with primary SjAPgren's syndrome and membranous glomerulonephritis. (23151312)
2012
5
An unusual cause of membranous glomerulonephritis in a patient with HIV. (21437594)
2012
6
Membranous glomerulonephritis secondary to neoplasia. Different forms of presentation. (22806299)
2012
7
Immunosuppressive treatment of idiopathic membranous glomerulonephritis with nephrotic syndrome]. (20088170)
2009
8
Membranous glomerulonephritis in a patient with ankylosing spondylitis: a rare association. (19652903)
2009
9
Successful therapeutic use of rituximab in refractory membranous glomerulonephritis. (16878436)
2006
10
IgA deficiency and membranous glomerulonephritis presenting as nephrotic syndrome. (15711951)
2005
11
Membranous glomerulonephritis associated with hepatitis C virus infection: case report and literature review. (14989635)
2004
12
Repeated pregnancies in patients with primary membranous glomerulonephritis. (12021515)
2002
13
Lupus membranous glomerulonephritis mimicking hepatitis C-associated nephropathy. (11877599)
2002
14
Membranoproliferative glomerulonephritis associated with hypocomplementemic urticarial vasculitis after complete remission of membranous nephropathy. (11399923)
2001
15
Membranous glomerulonephritis with nephrotic syndrome associated with chronic lymphocytic leukemia. (11092999)
2000
16
Decreased urinary excretion of vascular endothelial growth factor in idiopathic membranous glomerulonephritis. (10844604)
2000
17
Disseminated cutaneous plasmacellular granuloma associated with membranous glomerulonephritis. (10344377)
1999
18
The subepithelial formation of immune complexes in membranous glomerulonephritis may be harmless and secondary to toxic or allergic factors. (9822253)
1998
19
A case of membranous glomerulonephritis associated with gastric cancer. (9343999)
1997
20
Membranous glomerulonephritis with primary SjAPgren's syndrome detected by urine screening of school children. (8793242)
1996
21
Elevated plasma levels of acute phase proteins in mesangioproliferative glomerulonephritis, membranous nephropathy and IgA nephropathy. (7542398)
1995
22
A case of membranous glomerulonephritis with elevated serum level of CA-125. (8575132)
1995
23
Tubulointerstitial lesions in human membranous glomerulonephritis: relationship to proteinuria. (7872314)
1995
24
Hepatitis B virus associated membranous glomerulonephritis in children--experience in Hong Kong. (8403568)
1993
25
Idiopathic membranous glomerulonephritis in the elderly. (8252873)
1993
26
Idiopathic membranous glomerulonephritis: a clinicopathologic and quantitative morphometric study. (1499164)
1992
27
Predicting chronic renal insufficiency in idiopathic membranous glomerulonephritis. (1453588)
1992
28
Interferon treatment for hepatitis B-associated membranous glomerulonephritis in two Chinese children. (1280987)
1992
29
Experimental membranous glomerulonephritis in rats induced with gp 700, a glomerular protein. (1707302)
1990
30
Lupus membranous glomerulonephritis: different prognostic subgroups obscured by imprecise histologic classifications. (2326250)
1990
31
Glomerular deposition of C4 cleavage fragment (C4d) and C4-binding protein in idiopathic membranous glomerulonephritis. (2644563)
1989
32
Membranous glomerulonephritis associated with chronic progressive demyelinating neuropathy. (3027615)
1987
33
Membranous glomerulonephritis. (3950037)
1986
34
Absence of interferons-alpha and -gamma in renal lesions of systemic lupus erythematosus and membranous glomerulonephritis. (3081289)
1986
35
Membranous glomerulonephritis associated with enterococcal endocarditis. (4000340)
1985
36
Membranous glomerulonephritis in a patient with Crohn's disease of the small bowel. (3156982)
1985
37
Membranous glomerulonephritis in Hong Kong. (6465947)
1984
38
Deposition of hepatitis B e antigen in membranous glomerulonephritis: identification by F(ab')2 fragments of monoclonal antibody. (6513277)
1984
39
Membranous glomerulonephritis associated with industrial mercury exposure. Study of pathogenetic mechanisms. (7041618)
1982
40
Co-existing dermatitis herpetiformis and membranous glomerulonephritis. (7438513)
1980
41
Membranous glomerulonephritis, dermatomyositis, and bronchial carcinoma. (227526)
1979
42
Membranous glomerulonephritis associated with sarcoidosis. (282857)
1978
43
Relationship of levels of circulating immune complexes to histologic patterns of nephritis: a comparative study of membranous glomerulonephropathy and diffuse proliferative glomerulonephritis. (908876)
1977
44
Laboratory model of membranous glomerulonephritis in rats induced by pronase-digested homologous renal tubular epithelial antigen. (125817)
1975
45
Membranous glomerulonephritis in dogs infected with Dirofilaria immitis. (1189234)
1975
46
Letter: Hepatitis-B antigenaemia associated with progressive cirrhosis and membranous glomerulonephritis. (45990)
1975
47
Comparison of clinical and morphological features of peri- (epi-extra) membranous glomerulonephritis. (4607592)
1974
48
Idiopathic membranous glomerulonephritis in adults: remission following steroid therapy. (5343606)
1969
49
MEMBRANOUS GLOMERULONEPHRITIS: DISCUSSION AND CASE PRESENTATION. (14122647)
1964
50
The membranous and proliferative glomerulonephritis of hepatic cirrhosis. (13661122)
1959

Genetic Variations for Membranous Glomerulonephritis

Expression for genes affiliated with Membranous Glomerulonephritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Membranous Glomerulonephritis

Search GEO for disease gene expression data for Membranous Glomerulonephritis.

Pathways for genes affiliated with Membranous Glomerulonephritis

Sources:
12EMD Millipore, 54Reactome
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Pathways related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Lectin induced complement pathway
Hide members
10.1CLU, CD59, ITGB2

Compounds for genes affiliated with Membranous Glomerulonephritis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB
See all sources

Compounds related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1glutamate4510.6AGTR1, ITGB2
2cyclophosphamide45 50 1112.6MS4A1, ITGB2
3polyurethane4510.5ITGB2, PECAM1
4cv 119744510.5AGT, AGTR1
5silicone4510.4CD79A, ITGB2, F9
6cgp42112a4510.4AGTR1, AGT
7indomethacin45 60 29 1113.4NPHS1, CTSB, AGT
8chymotrypsinogen4510.4F9, CTSB
9aliskiren45 1111.4AGTR1, AGT
10rituximab45 50 1112.4F9, CD79A, CD59, MS4A1
11kininogen4510.3F9, CTSB, ITGB2, CLU
12captopril45 29 50 60 1114.3CD79A, AGT, AGTR1
13superoxide45 2411.3AGTR1, AGT, CD59, ENO1
14prednisolone45 29 1112.3CD79A, MPO, ITGB2, F9
15methacholine45 1111.3CD79A, AGTR1, MPO
16simvastatin45 50 60 29 11 2415.2AGT, AGTR1, ITGB2, NPHS1
17sialic acid4510.2F9, CD79A, CD59, CLU, PECAM1
18deoxyribonucleic acid4510.2CLU, AGT, AGTR1
19ivig4510.2F9, ITGB2, CD79A
20glucose4510.2NPHS1, CTSB, AGTR1, AGT, CD59
21isoproterenol45 1111.1CTSB, ITGB2, AGTR1, AGT
22cyclosporin a45 29 6012.1F9, CTSB, ITGB2, CD79A, CD59, PECAM1
23ethanol45 50 11 2413.1F9, CTSB, ITGB2, AGTR1, CLU
24sucrose45 11 2412.1F9, AGTR1, AGT, CD59
25n acetylcysteine4510.1MPO, AGTR1, AGT, CD79A, CLU
26actinomycin d4510.1CTSB, AGTR1, AGT, CLU, PECAM1
27cerulein4510.0MPO, CTSB
28dexamethasone45 50 29 1113.0F9, NPHS1, ITGB2, AGT, CD79A, CLU
29oxygen45 2411.0CTSB, MPO, AGT, CD59, CLU, PECAM1
30aspirin45 50 29 2413.0PECAM1, CD59, CD79A, AGTR1
31phenylephrine45 29 11 2413.0TRPC6, AGT, AGTR1
32paraffin459.9CTSB, MPO, AGT, CD79A, CLU, MS4A1
33saralasin459.8AGT, AGTR1
34lactate459.8CTSB, ITGB2, MPO, CD79A, CD59, CLU
35atp45 2910.8ITGB2, AGTR1, AGT, CD59, CLU, ENO1
36thymidine45 2410.8F9, CTSB, AGT, CLU, PECAM1
37heparin45 29 11 2412.8F9, CTSB, ITGB2, MPO, AGT, CD79A
38cholesterol45 29 11 2412.7F9, CTSB, ITGB2, AGTR1, AGT, CD59
39nitric oxide45 11 2411.7PECAM1, AGT, AGTR1, MPO, ITGB2, CTSB
40arginine459.7F9, NPHS1, CTSB, ITGB2, AGTR1, AGT
41fibrinogen459.6PECAM1, F9, CTSB, ITGB2, AGTR1, AGT
42retinoic acid45 2410.6NPHS1, CTSB, ITGB2, MPO, CD79A, CLU
43h2o2459.6F9, CTSB, ITGB2, MPO, AGTR1, AGT
44vegf459.6NPHS1, CTSB, ITGB2, MPO, AGTR1, AGT
45tyrosine459.6F9, NPHS1, CTSB, ITGB2, AGTR1, AGT
46cysteine459.6F9, CTSB, ITGB2, AGTR1, AGT, CD79A
47serine459.6F9, NPHS1, CTSB, ITGB2, MPO, AGTR1
48creatinine459.5F9, NPHS1, CTSB, ITGB2, MPO, SYNPO
49lipid459.4F9, NPHS1, ITGB2, AGTR1, AGT, TRPC6
50calcium45 50 11 2412.1F9, NPHS1, CTSB, ITGB2, MPO, AGTR1

GO Terms for genes affiliated with Membranous Glomerulonephritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:03605710.2TRPC6, NPHS1
2extracellular spaceGO:0056159.3PECAM1, CTSB, MPO, AGT, CD59, CLU
3plasma membraneGO:0058868.7F9, NPHS1, ITGB2, SYNPO, AGTR1, TRPC6

Biological processes related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.3AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.3AGTR1, AGT
3renin-angiotensin regulation of aldosterone productionGO:00201810.2AGT, AGTR1
4low-density lipoprotein particle remodelingGO:03437410.1AGT, AGTR1, MPO
5regulation of renal sodium excretionGO:03581310.1AGT, AGTR1
6positive regulation of macrophage derived foam cell differentiationGO:01074410.1AGT, AGTR1
7positive regulation of cholesterol esterificationGO:01087310.0AGTR1, AGT
8positive regulation of cellular protein metabolic processGO:0322709.8AGT, AGTR1
9blood coagulationGO:0075969.8PECAM1, F9, ITGB2, TRPC6, CD59, HBE1

Molecular functions related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activator activityGO:01069810.1AGT, AGTR1

Products for genes affiliated with Membranous Glomerulonephritis

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Sources for Membranous Glomerulonephritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet