MCID: MMB002
MIFTS: 60

Membranous Glomerulonephritis malady

Nephrological diseases category

Summaries for Membranous Glomerulonephritis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly... more...

MalaCards: Membranous Glomerulonephritis, also known as membranous nephropathy, is related to glomerulonephritis and hepatitis. An important gene associated with Membranous Glomerulonephritis is MBNP (?Membranous nephropathy, susceptibility to), and among its related pathways is Immune response Lectin induced complement pathway. The compounds glutamate and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone marrow and t cells, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Description from OMIM:46 614692

Aliases & Classifications for Membranous Glomerulonephritis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 46OMIM, 9diseasecard, 44Novoseek, 48Orphanet, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

membranous glomerulonephritis 8 42 10 60
membranous nephropathy 8 42 46
idiopathic membranous glomerulonephritis 48 60
idiopathic membranous nephropathy 42 44
membranous nephropathy, susceptibility to 9
extramembranous glomerulonephritis 42
glomerulonephritis, membranous 42
membranous nephropathy nos 8
nephropathy membranous 44
membranous gn 42


External Ids:

Disease Ontology8 DOID:10976
NCIt39 C34645
SNOMED-CT56 197710000, 77182004
MeSH34 D015433
OMIM46 614692

Related Diseases for Membranous Glomerulonephritis

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17GeneCards, 18GeneDecks
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Diseases in the Membranous Glomerulonephritis family:

Membranous Congenital Glomerulonephritis Due to Anti-Maternal Neutral Endopeptidase Alloimmunization

Diseases related to Membranous Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.9PECAM1, NPHS1, ITGB2, MPO, SYNPO, AGTR1
2hepatitis31.1HBE1, F9
3hepatitis b31.0F9, CTSB, CD79A, HBE1
4nephrotic syndrome30.9F9, NPHS1, SYNPO, AGT, TRPC6, CD79A
5lupus erythematosus30.7CD79A
6iga glomerulonephritis30.7NPHS1, AGTR1, AGT, CD79A
7systemic lupus erythematosus30.7ITGB2, MPO, CD79A, CD59, CLU, LAMB1
8hepatitis c30.6ENO1, CTSB, F9
9arthritis30.6CTSB, ITGB2, MPO, AGTR1, CD59, CLU
10rheumatoid arthritis30.5CTSB, ITGB2, MPO, CD79A, CD59, CLU
11hepatitis a30.5HBE1
12proteinuria30.5SYNPO, MPO, ITGB2, NPHS1, AGTR1, AGT
13myeloma30.4CD79A, ITGB2
14focal segmental glomerulosclerosis30.4NPHS1, AGTR1, AGT, TRPC6, CD79A
15purpura30.3CD79A
16proliferative glomerulonephritis30.3CD79A
17vasculitis30.3ENO1, CD79A, MPO, ITGB2
18pancreatitis30.1MPO, CTSB
19diabetes mellitus30.1NPHS1, ITGB2, AGTR1, AGT, CD79A, PECAM1
20ulcerative colitis30.1ITGB2, MPO, CD79A, CD59, ENO1, PECAM1
21leukemia30.1F9, ITGB2, MPO, CD79A, CD59, ENO1
22adenocarcinoma30.1CTSB, ITGB2, AGTR1, CD59, CLU, LAMB1
23thyroiditis29.9CD79A
24dermatitis29.9ITGB2, CD79A
25liver cirrhosis29.9AGT, HBE1
26prostatitis29.9CD79A
27thrombocytopenia29.9F9, CD79A, PECAM1
28membranoproliferative glomerulonephritis29.9CD79A, NPHS1
29peritonitis29.9ITGB2, MPO, PECAM1
30hypertension29.9CD79A, AGT, AGTR1
31macroglobulinemia29.9CD79A
32pneumonia29.9CD79A, MPO, CTSB
33diabetic nephropathy29.9AGT, AGTR1, SYNPO, NPHS1
34colon cancer29.9CLU, CD59, CTSB
35graves' disease29.9ITGB2, MPO, CD59
36melanoma29.9PECAM1, ENO1, CD59, CTSB
37prostate cancer29.9CTSB, SYNPO, AGTR1, TRPC6, CD59, CLU
38alport syndrome and thin basement membrane nephropathy10.5
39crescentic glomerulonephritis10.5
40immune-complex glomerulonephritis10.5
41alport syndrome10.5
42diffuse glomerulonephritis10.4
43thin basement membrane nephropathy10.4
44primary biliary cirrhosis10.4
45focal glomerulosclerosis10.4
46kidney disease10.3
47hepatitis e10.3
48multiple myeloma10.3
49lipoid nephrosis10.2
50ankylosing spondylitis10.2

Graphical network of the top 20 diseases related to Membranous Glomerulonephritis:



Diseases related to membranous glomerulonephritis

Clinical Features for Membranous Glomerulonephritis

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46OMIM
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Clinical features from OMIM:

614692

Drugs & Therapeutics for Membranous Glomerulonephritis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Membranous Glomerulonephritis

Drug clinical trials:

Search ClinicalTrials for Membranous Glomerulonephritis

Search NIH Clinical Center for Membranous Glomerulonephritis

Search CenterWatch for Membranous Glomerulonephritis

Genetic Tests for Membranous Glomerulonephritis

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Anatomical Context for Membranous Glomerulonephritis

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32MalaCards
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MalaCards organs/tissues related to Membranous Glomerulonephritis:

32
Kidney, Bone marrow, T cells, Liver, Endothelial, Bone, B cells, Skin, Testes, Thyroid, Pancreas, Lung, Lymph node, Spleen, Colon, Smooth muscle, Heart, Cortex

Animal Models for Membranous Glomerulonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Membranous Glomerulonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.4ITGB2, MPO, CD79A, CD59, IL27RA, MS4A1
2MP:00053679.2PECAM1, NPHS1, CTSB, SYNPO, AGTR1, AGT
3MP:00053859.0F9, ITGB2, MPO, AGTR1, AGT, TRPC6
4MP:00053878.9F9, CTSB, ITGB2, MPO, AGTR1, AGT
5MP:00053768.6MPO, ITGB2, CTSB, NPHS1, F9, AGTR1

Publications for Membranous Glomerulonephritis

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Sources:
50PubMed
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Articles related to Membranous Glomerulonephritis:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Effect of add-on pentoxifylline on proteinuria in membranous glomerulonephritis: a 6-month placebo-controlled trial. (23392759)
2013
2
Membranous glomerulonephritis is a manifestation of IgG4-related disease. (23254897)
2013
3
Anti-glomerular basement membrane glomerulonephritis and thrombotic microangiopathy in first degree relatives: a case report. (22834933)
2012
4
Corticosteroids worsen proteinuria and increase intraglomerular signaling by NF-A,B in a model of membranous glomerulonephritis. (20588061)
2010
5
Focal segmental glomerulosclerosis in idiopathic membranous glomerulonephritis: a clinico-pathological and stereological study. (19808947)
2010
6
Membranous glomerulonephritis in a patient with ankylosing spondylitis: a rare association. (19652903)
2009
7
Segmental membranous glomerulonephritis in children: comparison with global membranous glomerulonephritis. (17699279)
2006
8
Successful therapeutic use of rituximab in refractory membranous glomerulonephritis. (16878436)
2006
9
Antibodies to ribosomal P proteins: a potential serologic marker for lupus membranous glomerulonephritis. (16645990)
2006
10
Glomerular clusterin is associated with PKC-alpha/beta regulation and good outcome of membranous glomerulonephritis in humans. (16775601)
2006
11
CD20-positive infiltrates in human membranous glomerulonephritis. (16013025)
2005
12
Mycophenolate mofetil use in hepatitis B associated-membranous and membranoproliferative glomerulonephritis induces viral replication. (15671086)
2005
13
The increase of antiglomerular basement membrane antibody following pauci-immune-type crescentic glomerulonephritis. (15830277)
2005
14
Another case of HBV associated membranous glomerulonephritis resolving on lamivudine. (12716731)
2003
15
IgA deficiency with membranous glomerulonephritis: a case report and review. (12649548)
2003
16
Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis. (11796821)
2002
17
Lupus membranous glomerulonephritis mimicking hepatitis C-associated nephropathy. (11877599)
2002
18
Idiopathic membranous glomerulonephritis associated with primary antiphospholipid syndrome. (11096306)
2000
19
A comparison of the clinical and laboratory features of thin basement membrane disease (TBMD) and IgA glomerulonephritis (IgA GN). (10442488)
1999
20
Membranous glomerulonephritis induced in the pig by antibody to angiotensin-converting enzyme: considerations on its relevance to the pathogenesis of human idiopathic membranous glomerulonephritis. (10505686)
1999
21
Chronic idiopathic thrombocytopenic purpura in a patient with membranous glomerulonephritis. (10575298)
1999
22
A case of membranous glomerulonephritis associated with adenocarcinoma of pancreas. (9568885)
1998
23
Membranous glomerulonephritis associated with primary biliary cirrhosis. (9509463)
1998
24
Coexistence of membranous glomerulonephritis and Kaposi's sarcoma. (9678452)
1998
25
Membranous glomerulonephritis with primary SjAPgren's syndrome detected by urine screening of school children. (8793242)
1996
26
A case of membranous glomerulonephritis associated with Recklinghausen's neurofibromatosis. (9156954)
1996
27
Anti-neutrophil cytoplasm antibodies and anti-glomerular basement membrane antibodies: two coexisting distinct autoreactivities detectable in patients with rapidly progressive glomerulonephritis. (7544065)
1995
28
Glomerulocystic kidney disease associated with Wegener's granulomatosis and membranous glomerulonephritis: a case report. (7566625)
1995
29
Membranous glomerulonephritis and melanoma: a causal correlation? (8271289)
1994
30
Ultrastructural localization of the three major basement membrane components--type IV collagen, heparan sulfate proteoglycan and laminin--in human membranous glomerulonephritis. (8017478)
1994
31
Influence of clinical and histological features on actuarial renal survival in adult patients with idiopathic IgA nephropathy, membranous nephropathy, and membranoproliferative glomerulonephritis: survey of the recent literature. (1415198)
1992
32
Glomerular podocyte vacuolation in idiopathic membranous glomerulonephritis. (1528336)
1992
33
Effect of dipyridamole with or without aspirin on urine protein excretion in patients with membranous glomerulonephritis. (1425898)
1992
34
Membranous glomerulonephritis as an outstanding feature of renal lesions in autoimmune graft-vs-host F1 mice. (2292809)
1990
35
Membranous glomerulonephritis and pregnancy. (3359693)
1988
36
Membranous glomerulonephritis and Grover disease with diverse neurological abnormalities; an immunological disorder due to poliovirus infection? (2831306)
1988
37
Membranous glomerulonephritis in rheumatoid arthritis unassociated with gold or penicillamine treatment. (3632071)
1987
38
Ultrastructural alterations in the sialic acid distribution in minimal change disease and membranous glomerulonephritis. (3601794)
1987
39
Absence of interferons-alpha and -gamma in renal lesions of systemic lupus erythematosus and membranous glomerulonephritis. (3081289)
1986
40
Idiopathic membranous glomerulonephritis: aspects of geographical differences. (3793935)
1986
41
Evolution of membranous nephropathy from a proliferative and exudative glomerulonephritis--a report of three cases studied by serial biopsies. (3897088)
1985
42
Recurrent membranous glomerulonephritis in two renal transplants. (3892786)
1985
43
Idiopathic membranous glomerulonephritis in diabetic patients: report of three cases and review of the literature. (7396588)
1980
44
Membranous glomerulonephritis and myasthenia gravis. (6451660)
1980
45
Membranous glomerulonephritis, dermatomyositis, and bronchial carcinoma. (227526)
1979
46
Membranous glomerulonephritis in congenital syphilis. (383337)
1979
47
Experimental membranous glomerulonephritis in rats: correlation of ultrastructural changes with the serum level of autologous antibody against tubular antigen. (150473)
1978
48
The natural history and treatment of membranous glomerulonephritis. (4536438)
1973
49
Idiopathic membranous glomerulonephritis occurring with diabetes mellitus. (4584310)
1973
50
Diffuse membranous glomerulonephritis in children. (4958475)
1966

Genetic Variations for Membranous Glomerulonephritis

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Expression for genes affiliated with Membranous Glomerulonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Membranous Glomerulonephritis

Search GEO for disease gene expression data for Membranous Glomerulonephritis.

Pathways for genes affiliated with Membranous Glomerulonephritis

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12EMD Millipore, 53Reactome
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Pathways related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Lectin induced complement pathway
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10.1CLU, CD59, ITGB2

Compounds for genes affiliated with Membranous Glomerulonephritis

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1glutamate4410.6AGTR1, ITGB2
2cyclophosphamide44 49 1112.6MS4A1, ITGB2
3polyurethane4410.5ITGB2, PECAM1
4cv 119744410.5AGT, AGTR1
5silicone4410.4CD79A, ITGB2, F9
6cgp42112a4410.4AGTR1, AGT
7indomethacin44 59 28 1113.4NPHS1, CTSB, AGT
8chymotrypsinogen4410.4F9, CTSB
9aliskiren44 1111.4AGTR1, AGT
10rituximab44 49 1112.4F9, CD79A, CD59, MS4A1
11kininogen4410.3F9, CTSB, ITGB2, CLU
12captopril44 28 49 59 1114.3CD79A, AGT, AGTR1
13superoxide44 2411.3AGTR1, AGT, CD59, ENO1
14prednisolone44 28 1112.3CD79A, MPO, ITGB2, F9
15methacholine44 1111.3CD79A, AGTR1, MPO
16simvastatin44 49 59 28 11 2415.2AGT, AGTR1, ITGB2, NPHS1
17sialic acid4410.2F9, CD79A, CD59, CLU, PECAM1
18deoxyribonucleic acid4410.2CLU, AGT, AGTR1
19ivig4410.2F9, ITGB2, CD79A
20glucose4410.2NPHS1, CTSB, AGTR1, AGT, CD59
21isoproterenol44 1111.1CTSB, ITGB2, AGTR1, AGT
22cyclosporin a44 28 5912.1F9, CTSB, ITGB2, CD79A, CD59, PECAM1
23ethanol44 49 11 2413.1F9, CTSB, ITGB2, AGTR1, CLU
24sucrose44 11 2412.1F9, AGTR1, AGT, CD59
25n acetylcysteine4410.1MPO, AGTR1, AGT, CD79A, CLU
26actinomycin d4410.1CTSB, AGTR1, AGT, CLU, PECAM1
27cerulein4410.0MPO, CTSB
28dexamethasone44 49 28 1113.0F9, NPHS1, ITGB2, AGT, CD79A, CLU
29oxygen44 2411.0CTSB, MPO, AGT, CD59, CLU, PECAM1
30aspirin44 49 28 2413.0PECAM1, CD59, CD79A, AGTR1
31phenylephrine44 28 11 2413.0TRPC6, AGT, AGTR1
32paraffin449.9CTSB, MPO, AGT, CD79A, CLU, MS4A1
33saralasin449.8AGT, AGTR1
34lactate449.8CTSB, ITGB2, MPO, CD79A, CD59, CLU
35atp44 2810.8ITGB2, AGTR1, AGT, CD59, CLU, ENO1
36thymidine44 2410.8F9, CTSB, AGT, CLU, PECAM1
37heparin44 28 11 2412.8F9, CTSB, ITGB2, MPO, AGT, CD79A
38cholesterol44 28 11 2412.7F9, CTSB, ITGB2, AGTR1, AGT, CD59
39nitric oxide44 11 2411.7PECAM1, AGT, AGTR1, MPO, ITGB2, CTSB
40arginine449.7F9, NPHS1, CTSB, ITGB2, AGTR1, AGT
41fibrinogen449.6PECAM1, F9, CTSB, ITGB2, AGTR1, AGT
42retinoic acid44 2410.6NPHS1, CTSB, ITGB2, MPO, CD79A, CLU
43h2o2449.6F9, CTSB, ITGB2, MPO, AGTR1, AGT
44vegf449.6NPHS1, CTSB, ITGB2, MPO, AGTR1, AGT
45tyrosine449.6F9, NPHS1, CTSB, ITGB2, AGTR1, AGT
46cysteine449.6F9, CTSB, ITGB2, AGTR1, AGT, CD79A
47serine449.6F9, NPHS1, CTSB, ITGB2, MPO, AGTR1
48creatinine449.5F9, NPHS1, CTSB, ITGB2, MPO, SYNPO
49lipid449.4F9, NPHS1, ITGB2, AGTR1, AGT, TRPC6
50calcium44 49 11 2412.1F9, NPHS1, CTSB, ITGB2, MPO, AGTR1

GO Terms for genes affiliated with Membranous Glomerulonephritis

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16Gene Ontology
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Cellular components related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:03605710.2TRPC6, NPHS1
2extracellular spaceGO:0056159.3PECAM1, CTSB, MPO, AGT, CD59, CLU
3plasma membraneGO:0058868.7F9, NPHS1, ITGB2, SYNPO, AGTR1, TRPC6

Biological processes related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.3AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.3AGTR1, AGT
3renin-angiotensin regulation of aldosterone productionGO:00201810.2AGT, AGTR1
4low-density lipoprotein particle remodelingGO:03437410.1AGT, AGTR1, MPO
5regulation of renal sodium excretionGO:03581310.1AGT, AGTR1
6positive regulation of macrophage derived foam cell differentiationGO:01074410.1AGT, AGTR1
7positive regulation of cholesterol esterificationGO:01087310.0AGTR1, AGT
8positive regulation of cellular protein metabolic processGO:0322709.8AGT, AGTR1
9blood coagulationGO:0075969.8PECAM1, F9, ITGB2, TRPC6, CD59, HBE1

Molecular functions related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activator activityGO:01069810.1AGT, AGTR1

Products for genes affiliated with Membranous Glomerulonephritis

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  • Antibodies
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Sources for Membranous Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet