MCID: MMB002
MIFTS: 40

Membranous Glomerulonephritis malady

Nephrological diseases category

Summaries for Membranous Glomerulonephritis

About this section


Wikipedia:63 Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly... more...

MalaCards based summary: Membranous Glomerulonephritis, also known as membranous nephropathy nos, is related to glomerulonephritis and nephrotic syndrome. An important gene associated with Membranous Glomerulonephritis is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Hematopoietic cell lineage and Lymphocyte Signaling. The compounds hematoxylin and azathioprine have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and bone marrow, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Aliases & Classifications for Membranous Glomerulonephritis

About this section

Membranous Glomerulonephritis, Aliases & Descriptions:

Name: Membranous Glomerulonephritis 9 11 60
Membranous Nephropathy Nos 9
 
Membranous Nephropathy 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:10976
MeSH33 D015433
SNOMED-CT55 197710000, 77182004
NCIt38 C34645

Related Diseases for Membranous Glomerulonephritis

About this section

Diseases related to Membranous Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.1CD59, CD79A, NPHS1, SYNPO, PECAM1
2nephrotic syndrome30.7SYNPO, NPHS1, CD79A
3nephritis30.6NPHS1, CD79A
4glomerulosclerosis30.6NPHS1, CD79A
5membranous glomerulonephritis, antenatal30.5CD59, CD79A, NPHS1
6macroglobulinemia30.4CD79A
7lipoid nephrosis30.4NPHS1, CD79A
8polyneuropathy30.4CD79A
9chronic lymphocytic leukemia30.3CD59, MS4A1
10focal segmental glomerulosclerosis30.2SYNPO, NPHS1, CD79A
11iga glomerulonephritis30.2CD79A, NPHS1
12rheumatoid arthritis30.2CD59, CD79A, PECAM1
13membranoproliferative glomerulonephritis30.1CD79A, NPHS1
14proteinuria30.0SYNPO, NPHS1, CD79A, CD59
15ulcerative colitis30.0CD59, CD79A, PECAM1
16thrombocytopenia29.8PECAM1, CD79A
17hepatitis10.8
18hepatitis b10.7
19alport syndrome and thin basement membrane nephropathy10.6
20systemic lupus erythematosus10.5
21lupus erythematosus10.5
22alport syndrome10.5
23hematuria, benign familial10.5
24hepatitis c10.5
25hepatitis c virus10.5
26arthritis10.5
27primary biliary cirrhosis10.4
28multiple myeloma10.3
29anti-basement membrane glomerulonephritis10.3
30kidney disease10.3
31myeloma10.3
32nephrosis10.3
33colitis10.3
34polyradiculoneuropathy10.3
35pulmonary embolism10.3
36purpura10.3
37sarcoma10.3
38spondylitis10.3
39syphilis10.3
40vasculitis10.3
41retroperitoneal fibrosis10.3
42congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization10.3
43waldenstrom macroglobulinemia10.2CD59, MS4A1
44follicular lymphoma10.2MS4A1, CD59
45kaposi sarcoma10.2
46renal cell carcinoma10.2
47autoimmune hepatitis10.2
48b-cell lymphomas10.2
49leukemia10.2
50antiphospholipid syndrome10.2

Graphical network of the top 20 diseases related to Membranous Glomerulonephritis:



Diseases related to membranous glomerulonephritis

Symptoms for Membranous Glomerulonephritis

About this section

Drugs & Therapeutics for Membranous Glomerulonephritis

About this section

Drug clinical trials:

Search ClinicalTrials for Membranous Glomerulonephritis

Search NIH Clinical Center for Membranous Glomerulonephritis

Genetic Tests for Membranous Glomerulonephritis

About this section

Anatomical Context for Membranous Glomerulonephritis

About this section

MalaCards organs/tissues related to Membranous Glomerulonephritis:

31
Kidney, Liver, Bone marrow, Bone, T cells, B cells, Endothelial, Lymph node, Spleen, Cortex, Heart, Smooth muscle, Colon, Lung, Pancreas, Thyroid, Skin, Testes, Neutrophil

Animal Models for Membranous Glomerulonephritis or affiliated genes

About this section

MGI Mouse Phenotypes related to Membranous Glomerulonephritis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.1CD59, CD79A, MS4A1, PECAM1
2MP:00053677.2CD59, CD79A, NPHS1, SYNPO, PECAM1

Publications for Membranous Glomerulonephritis

About this section

Articles related to Membranous Glomerulonephritis:

(show top 50)    (show all 469)
idTitleAuthorsYear
1
Varenicline induced acute interstitial nephritis in the setting of idiopathic membranous glomerulonephritis. (24215355)
2013
2
Toll-like receptor 9 SNPs are susceptible to the development and progression of membranous glomerulonephritis: 27 years follow-up in Taiwan. (23964786)
2013
3
Antiribosomal-P protein antibodies are associated with proliferative glomerulonephritis more strongly than with membranous glomerulonephritis in Japanese patients with systemic lupus erythematosus. (22042098)
2012
4
Membranous glomerulonephritis, psoriasis and etanercept. A chance or causal association? (22421953)
2012
5
Anti-glomerular basement membrane glomerulonephritis and thrombotic microangiopathy in first degree relatives: a case report. (22834933)
2012
6
New insights into membranous glomerulonephritis: from bench to bedside. (21803731)
2011
7
Natural recovery from antiglomerular basement membrane glomerulonephritis is associated with glomeruli-infiltrating CD8I++CD11c+MHC class II+ cells. (22068125)
2011
8
An uncommon cause of membranous glomerulonephritis. (19643521)
2010
9
Corticosteroids worsen proteinuria and increase intraglomerular signaling by NF-A,B in a model of membranous glomerulonephritis. (20588061)
2010
10
Subclinical acquired syphilis masquerading as membranous glomerulonephritis. (17243528)
2006
11
Focal segmental glomerulosclerosis after membranous glomerulonephritis in remission: temporal diversity of glomerulopathy after bone marrow transplantation. (17020780)
2006
12
Concurrent anti-glomerular basement membrane disease and membranous glomerulonephritis: a case report and literature review. (16939068)
2006
13
CD20-positive infiltrates in human membranous glomerulonephritis. (16013025)
2005
14
Coexistence of idiopathic membranous glomerulonephritis and idiopathic focal segmental glomerulosclerosis. (16370166)
2005
15
Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis. (11796821)
2002
16
Bucillamine induces membranous glomerulonephritis. (11920335)
2002
17
Membranous glomerulonephritis, antiphospholipid syndrome, and persistent low C3 levels associated with meningococcal disease. (12053076)
2002
18
Nephrotic syndrome associated with focal segmental glomerulosclerosis in a patient with systemic lupus erythematosus and membranous glomerulonephritis in remission (10561162)
1999
19
Membranous Glomerulonephritis in a Patient Presenting with Chyluria, Probably due to Filariasis: How far should we investigate? (18212428)
1999
20
Diffuse thin glomerular basement membrane in association with idiopathic membranous glomerulonephritis. (9776416)
1998
21
Membranous glomerulonephritis with primary SjAPgren's syndrome detected by urine screening of school children. (8793242)
1996
22
Collagen distribution in human membranous glomerulonephritis. (8611347)
1996
23
Hepatitis C virus associated membranous glomerulonephritis. (8556829)
1995
24
Low-dose prednisolone/chlorambucil therapy in patients with severe membranous glomerulonephritis. (8043974)
1994
25
Membranous glomerulonephritis and melanoma: a causal correlation? (8271289)
1994
26
Heymann nephritis revisited--new insights into the pathogenesis of experimental membranous glomerulonephritis. (8252799)
1993
27
Membranous glomerulonephritis and malignancy. (8322793)
1993
28
Hepatitis B virus associated membranous glomerulonephritis in children--experience in Hong Kong. (8403568)
1993
29
Idiopathic membranous glomerulonephritis: a clinicopathologic and quantitative morphometric study. (1499164)
1992
30
Experimental membranous glomerulonephritis in rats induced with gp 700, a glomerular protein. (1707302)
1990
31
Glomerular deposition of C4 cleavage fragment (C4d) and C4-binding protein in idiopathic membranous glomerulonephritis. (2644563)
1989
32
Accelerated passive Heymann nephritis in rats as an experimental model for membranous glomerulonephritis and effects of azathioprine and prednisolone on the nephritis. (2724671)
1989
33
The glomerular distribution of type IV collagen and laminin in human membranous glomerulonephritis. (3275581)
1988
34
Allograft membranous glomerulonephritis and renal-vein thrombosis in a patient with a lupus anticoagulant factor. (3146730)
1988
35
Membranous glomerulonephritis associated with chronic progressive demyelinating neuropathy. (3027615)
1987
36
A controlled trial of cyclophosphamide in patients with membranous glomerulonephritis. (3323596)
1987
37
Membranous glomerulonephritis in rheumatoid arthritis unrelated to gold or penicillamine treatment. (4042448)
1985
38
Membranous glomerulonephritis associated with enterococcal endocarditis. (4000340)
1985
39
Familial idiopathic membranous glomerulonephritis. (6597809)
1984
40
Mechanism of hematuria in glomerular disease. An electron microscopic study in a case of diffuse membranous glomerulonephritis. (6888629)
1983
41
Segmental membranous glomerulonephritis. (7049118)
1982
42
Hepatitis B e antigen-mediated membranous glomerulonephritis. Correlation of ultrastructural changes with HBeAg in the serum and glomeruli. (7464047)
1981
43
Idiopathic membranous glomerulonephritis with crescents. (7020333)
1981
44
Lack of evidence for a role of renal tubular antigen in human membranous glomerulonephritis. (7022245)
1981
45
Extensive crescent formation in idiopathic membranous glomerulonephritis. A case report. (7321940)
1981
46
Experimental membranous glomerulonephritis in rats. Quantitative studies of glomerular immune deposit formation in isolated glomeruli and whole animals. (7400310)
1980
47
Membranous glomerulonephritis, dermatomyositis, and bronchial carcinoma. (227526)
1979
48
Membranous glomerulonephritis in congenital syphilis. (383337)
1979
49
Change from diffuse proliferative to membranous glomerulonephritis: serial biopsies in four cases. (4591751)
1974
50
Histometrical glomerular studies on the kidneys in multiple myeloma and in acute membranous glomerulonephritis (lipoid nephrosis). (5145535)
1971

Variations for Membranous Glomerulonephritis

About this section

Expression for genes affiliated with Membranous Glomerulonephritis

About this section
Search GEO for disease gene expression data for Membranous Glomerulonephritis.

Pathways for genes affiliated with Membranous Glomerulonephritis

About this section

Pathways related to Membranous Glomerulonephritis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CD59, MS4A1
29.0CD79A, PECAM1

Compounds for genes affiliated with Membranous Glomerulonephritis

About this section

Compounds related to Membranous Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 15)
idCompoundScoreTop Affiliating Genes
1hematoxylin439.6MS4A1, PECAM1
2azathioprine43 2 49 1212.2CD79A, CD59
3inositol439.0CD59, CD79A
4rituximab43 49 1211.0CD59, CD79A, MS4A1
5creatinine438.9SYNPO, NPHS1, CD79A
6paraffin438.9CD79A, MS4A1, PECAM1
7steroid438.8CD79A, NPHS1, SYNPO
8sialic acid438.8PECAM1, CD79A, CD59
9aspirin43 49 28 2411.8CD59, CD79A, PECAM1
10formaldehyde43 249.7CD79A, PECAM1
11cyclosporin a43 28 5910.7CD59, CD79A, PECAM1
12lipid438.7PECAM1, MS4A1, NPHS1, CD59
13vegf438.6CD79A, NPHS1, PECAM1
14retinoic acid43 249.5CD79A, NPHS1, PECAM1
15calcium43 49 24 1211.4PECAM1, MS4A1, NPHS1, CD59

GO Terms for genes affiliated with Membranous Glomerulonephritis

About this section

Cellular components related to Membranous Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:00451219.1CD79A, NPHS1
2extracellular vesicular exosomeGO:00700628.1CD59, NPHS1, MS4A1, PECAM1

Biological processes related to Membranous Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:00421009.2CD79A, MS4A1

Products for genes affiliated with Membranous Glomerulonephritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Membranous Glomerulonephritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet