MGN
MCID: MMB002
MIFTS: 51

Membranous Glomerulonephritis (MGN) malady

Rare diseases, Nephrological diseases categories

Summaries for Membranous Glomerulonephritis

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly... more...

MalaCards: Membranous Glomerulonephritis, also known as membranous nephropathy, is related to glomerulonephritis and nephrotic syndrome. An important gene associated with Membranous Glomerulonephritis is MBNP (?Membranous nephropathy, susceptibility to), and among its related pathways is Lymphocyte Signaling. The compounds rituximab and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and endothelial, and related mouse phenotype renal/urinary system.

Description from OMIM:48 614692

Aliases & Classifications for Membranous Glomerulonephritis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 63UMLS, 48OMIM, 10diseasecard, 46Novoseek, 50Orphanet, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases
Orphanet: 50 
Rare renal diseases


Aliases & Descriptions:

membranous glomerulonephritis 9 44 11 63
membranous nephropathy 9 44 48
idiopathic membranous glomerulonephritis 50 63
idiopathic membranous nephropathy 44 46
membranous nephropathy, susceptibility to 10
extramembranous glomerulonephritis 44
glomerulonephritis, membranous 44
membranous nephropathy nos 9
nephropathy membranous 46
membranous gn 44
mgn 44


External Ids:

Disease Ontology9 DOID:10976
NCIt41 C34645
SNOMED-CT59 197710000, 77182004
MeSH36 D015433
OMIM48 614692

Related Diseases for Membranous Glomerulonephritis

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18GeneCards, 19GeneDecks
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Diseases related to Membranous Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.9PECAM1, SYNPO, NPHS1, CD79A
2nephrotic syndrome30.9SYNPO, CD79A, NPHS1
3glomerulosclerosis30.6CD79A, NPHS1
4nephritis30.6NPHS1, CD79A
5proteinuria30.5SYNPO, NPHS1, CD79A
6focal segmental glomerulosclerosis30.4SYNPO, CD79A, NPHS1
7lipoid nephrosis30.4NPHS1, CD79A
8iga glomerulonephritis30.2CD79A, NPHS1
9diabetes mellitus30.1PECAM1, NPHS1, CD79A
10ulcerative colitis30.1CD79A, PECAM1
11macroglobulinemia30.1CD79A
12diabetic nephropathy30.0NPHS1, SYNPO
13membranoproliferative glomerulonephritis30.0CD79A, NPHS1
14thrombocytopenia30.0CD79A, PECAM1
15thin basement membrane nephropathy10.9
16hepatitis10.8
17hepatitis b10.7
18alport syndrome and thin basement membrane nephropathy10.5
19systemic lupus erythematosus10.5
20lupus erythematosus10.5
21alport syndrome10.5
22hepatitis c10.5
23arthritis10.5
24hepatitis c virus10.5
25rheumatoid arthritis10.4
26primary biliary cirrhosis10.4
27multiple myeloma10.3
28myeloma10.3
29nephrosis10.3
30ankylosing spondylitis10.2
31anti-basement membrane glomerulonephritis10.2
32kidney disease10.2
33polyradiculoneuropathy10.2
34pulmonary embolism10.2
35purpura10.2
36spondylitis10.2
37syphilis10.2
38vasculitis10.2
39retroperitoneal fibrosis10.2
40ophthalmoplegia10.2
41neurofibromatosis10.2
42antiphospholipid syndrome10.2
43autoimmune hepatitis10.2
44chronic inflammatory demyelinating polyradiculoneuropathy10.2
45cerebritis10.2
46crescentic glomerulonephritis10.2
47adenocarcinoma10.2
48chronic lymphocytic leukemia10.2
49hodgkin's lymphoma10.2
50interstitial nephritis10.2

Graphical network of the top 20 diseases related to Membranous Glomerulonephritis:



Diseases related to membranous glomerulonephritis

Symptoms for Membranous Glomerulonephritis

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48OMIM
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Clinical features from OMIM:

614692

Drugs & Therapeutics for Membranous Glomerulonephritis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Membranous Glomerulonephritis

Drug clinical trials:

Search ClinicalTrials for Membranous Glomerulonephritis

Search NIH Clinical Center for Membranous Glomerulonephritis

Search CenterWatch for Membranous Glomerulonephritis

Genetic Tests for Membranous Glomerulonephritis

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Anatomical Context for Membranous Glomerulonephritis

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34MalaCards
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MalaCards organs/tissues related to Membranous Glomerulonephritis:

34
Kidney, Liver, Endothelial, Bone, Bone marrow, B cells, T cells, Thyroid, Skin, Pancreas, Colon, Smooth muscle, Heart, Testes, Lymph node, Lung, Spleen, Cortex

Animal Models for Membranous Glomerulonephritis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Membranous Glomerulonephritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.0CD79A, NPHS1, SYNPO, PECAM1

Publications for Membranous Glomerulonephritis

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53PubMed
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Articles related to Membranous Glomerulonephritis:

(show top 50)    (show all 464)
idTitleAuthorsYear
1
Varenicline induced acute interstitial nephritis in the setting of idiopathic membranous glomerulonephritis. (24215355)
2013
2
Toll-like receptor 9 SNPs are susceptible to the development and progression of membranous glomerulonephritis: 27 years follow-up in Taiwan. (23964786)
2013
3
Antiribosomal-P protein antibodies are associated with proliferative glomerulonephritis more strongly than with membranous glomerulonephritis in Japanese patients with systemic lupus erythematosus. (22042098)
2012
4
Membranous glomerulonephritis, psoriasis and etanercept. A chance or causal association? (22421953)
2012
5
Anti-glomerular basement membrane glomerulonephritis and thrombotic microangiopathy in first degree relatives: a case report. (22834933)
2012
6
New insights into membranous glomerulonephritis: from bench to bedside. (21803731)
2011
7
Natural recovery from antiglomerular basement membrane glomerulonephritis is associated with glomeruli-infiltrating CD8I++CD11c+MHC class II+ cells. (22068125)
2011
8
An uncommon cause of membranous glomerulonephritis. (19643521)
2010
9
Corticosteroids worsen proteinuria and increase intraglomerular signaling by NF-A,B in a model of membranous glomerulonephritis. (20588061)
2010
10
Subclinical acquired syphilis masquerading as membranous glomerulonephritis. (17243528)
2006
11
Focal segmental glomerulosclerosis after membranous glomerulonephritis in remission: temporal diversity of glomerulopathy after bone marrow transplantation. (17020780)
2006
12
Concurrent anti-glomerular basement membrane disease and membranous glomerulonephritis: a case report and literature review. (16939068)
2006
13
CD20-positive infiltrates in human membranous glomerulonephritis. (16013025)
2005
14
Coexistence of idiopathic membranous glomerulonephritis and idiopathic focal segmental glomerulosclerosis. (16370166)
2005
15
Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis. (11796821)
2002
16
Bucillamine induces membranous glomerulonephritis. (11920335)
2002
17
Membranous glomerulonephritis, antiphospholipid syndrome, and persistent low C3 levels associated with meningococcal disease. (12053076)
2002
18
Nephrotic syndrome associated with focal segmental glomerulosclerosis in a patient with systemic lupus erythematosus and membranous glomerulonephritis in remission (10561162)
1999
19
Membranous Glomerulonephritis in a Patient Presenting with Chyluria, Probably due to Filariasis: How far should we investigate? (18212428)
1999
20
Diffuse thin glomerular basement membrane in association with idiopathic membranous glomerulonephritis. (9776416)
1998
21
Membranous glomerulonephritis with primary SjAPgren's syndrome detected by urine screening of school children. (8793242)
1996
22
Collagen distribution in human membranous glomerulonephritis. (8611347)
1996
23
Hepatitis C virus associated membranous glomerulonephritis. (8556829)
1995
24
Low-dose prednisolone/chlorambucil therapy in patients with severe membranous glomerulonephritis. (8043974)
1994
25
Membranous glomerulonephritis and melanoma: a causal correlation? (8271289)
1994
26
Heymann nephritis revisited--new insights into the pathogenesis of experimental membranous glomerulonephritis. (8252799)
1993
27
Membranous glomerulonephritis and malignancy. (8322793)
1993
28
Long-term benefits of therapy with cyclophosphamide and prednisone in patients with membranous glomerulonephritis and impaired renal function. (1739084)
1992
29
Idiopathic membranous glomerulonephritis: a clinicopathologic and quantitative morphometric study. (1499164)
1992
30
Experimental membranous glomerulonephritis in rats induced with gp 700, a glomerular protein. (1707302)
1990
31
Glomerular deposition of C4 cleavage fragment (C4d) and C4-binding protein in idiopathic membranous glomerulonephritis. (2644563)
1989
32
Accelerated passive Heymann nephritis in rats as an experimental model for membranous glomerulonephritis and effects of azathioprine and prednisolone on the nephritis. (2724671)
1989
33
The glomerular distribution of type IV collagen and laminin in human membranous glomerulonephritis. (3275581)
1988
34
Allograft membranous glomerulonephritis and renal-vein thrombosis in a patient with a lupus anticoagulant factor. (3146730)
1988
35
Membranous glomerulonephritis associated with chronic progressive demyelinating neuropathy. (3027615)
1987
36
A controlled trial of cyclophosphamide in patients with membranous glomerulonephritis. (3323596)
1987
37
Membranous glomerulonephritis in rheumatoid arthritis unrelated to gold or penicillamine treatment. (4042448)
1985
38
Membranous glomerulonephritis associated with enterococcal endocarditis. (4000340)
1985
39
Familial idiopathic membranous glomerulonephritis. (6597809)
1984
40
Segmental membranous glomerulonephritis. (7049118)
1982
41
Hepatitis B e antigen-mediated membranous glomerulonephritis. Correlation of ultrastructural changes with HBeAg in the serum and glomeruli. (7464047)
1981
42
Idiopathic membranous glomerulonephritis with crescents. (7020333)
1981
43
Lack of evidence for a role of renal tubular antigen in human membranous glomerulonephritis. (7022245)
1981
44
Extensive crescent formation in idiopathic membranous glomerulonephritis. A case report. (7321940)
1981
45
Experimental membranous glomerulonephritis in rats. Quantitative studies of glomerular immune deposit formation in isolated glomeruli and whole animals. (7400310)
1980
46
Membranous glomerulonephritis, dermatomyositis, and bronchial carcinoma. (227526)
1979
47
Membranous glomerulonephritis in congenital syphilis. (383337)
1979
48
Recurrent idiopathic membranous glomerulonephritis. (329496)
1977
49
Change from diffuse proliferative to membranous glomerulonephritis: serial biopsies in four cases. (4591751)
1974
50
Histometrical glomerular studies on the kidneys in multiple myeloma and in acute membranous glomerulonephritis (lipoid nephrosis). (5145535)
1971

Variations for Membranous Glomerulonephritis

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Expression for genes affiliated with Membranous Glomerulonephritis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Membranous Glomerulonephritis

Search GEO for disease gene expression data for Membranous Glomerulonephritis.

Pathways for genes affiliated with Membranous Glomerulonephritis

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51PathCards, 5Cell Signaling Technology
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Pathways related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CD79A, PECAM1

Compounds for genes affiliated with Membranous Glomerulonephritis

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46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR
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Compounds related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1rituximab46 52 1211.7CD79A, MS4A1
2hematoxylin469.4MS4A1, PECAM1
3sialic acid469.2CD79A, PECAM1
4formaldehyde46 2510.1PECAM1, CD79A
5agar469.1CD79A, PECAM1
6creatinine469.0CD79A, NPHS1, SYNPO
7steroid469.0CD79A, NPHS1, SYNPO
8paraffin468.9CD79A, PECAM1, MS4A1
9aspirin46 52 30 2511.8CD79A, PECAM1
10vegf468.6CD79A, NPHS1, PECAM1
11retinoic acid46 259.4PECAM1, NPHS1, CD79A

GO Terms for genes affiliated with Membranous Glomerulonephritis

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17Gene Ontology
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Cellular components related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.5CD79A, MS4A1
2membrane raftGO:0451219.0CD79A, NPHS1

Biological processes related to Membranous Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:0421009.5CD79A, MS4A1

Products for genes affiliated with Membranous Glomerulonephritis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Membranous Glomerulonephritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet