MCID: MMR004
MIFTS: 52

Memory Impairment malady

Summaries for Memory Impairment

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Amnesia (from Greek ἀμνησία, \"ἀ\" meaning \"without\", \"μνησία\" memory) is a deficit... more...

MalaCards: Memory Impairment is related to alzheimer's disease and temporal lobe epilepsy. An important gene associated with Memory Impairment is BDNF (brain-derived neurotrophic factor), and among its related pathways are Erythropoietin Pathway and Alcoholism. The compounds lithium and methamphetamine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and cortex, and related mouse phenotypes are integument and respiratory system.

Aliases & Classifications for Memory Impairment

Sources:
47OMIM, 45Novoseek, 61UMLS
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Aliases & Descriptions:

memory impairment 47 45 61


Related Diseases for Memory Impairment

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Memory Impairment via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1alzheimer's disease36.0HSD17B10, BDNF, CALB1, PDYN, HTR1A, HTR2A
2temporal lobe epilepsy35.4BDNF, CALB1, PDYN, HTR1A, GRIN1, TSPO
3obsessive-compulsive disorder35.1BDNF, PDYN, HTR1A, HTR2A, DRD1, TSPO
4attention deficit hyperactivity disorder34.9DRD1, HTR2A, BDNF
5cadasil34.9HTR1A, HTR2A, APOE, PSEN1, CHAT, TRH
6tauopathy34.9CDK5, PSEN1, APP
7vascular dementia30.4APOE
8brain disease30.4APP, PSEN1, ITIH4, CHAT, TSPO
9bipolar disorder30.1BDNF, HTR1A
10status epilepticus29.9BDNF
11fibromyalgia29.9HTR2A, TSPO
12hemorrhage, intracerebral29.9APP, APOE, PSEN1
13frontotemporal dementia29.9APP, APOE, PSEN1, ACHE
14schizoaffective disorder29.9HTR2A, BDNF
15parkinson's disease13.3BDNF, FMR1, CALB1, PDYN, HTR1A, HTR2A
16cholera13.3ACHE, TRH, CHAT, DRD1, HTR1A
17narcolepsy13.3DRD1, HTR2A
18autistic disorder13.3FMR1, BDNF
19huntington's disease13.3BDNF, CALB1, APP, PSEN1, DRD1, CHAT
20gilles de la tourette syndrome13.3HTR1A, HTR2A, DRD1
21lewy body dementia13.3ACHE, CDK5, APOE, APP
22sudden infant death syndrome13.3HTR1A, HTR2A, CHAT, GRIN1
23toxic encephalopathy13.3BDNF, APP, CHAT, CDK5
24ganglioglioma13.3GRIN1
25cocaine dependence13.3PDYN
26down syndrome13.3FMR1, HTR1A, APP, APOE, PSEN1, CHAT
27alcohol dependence13.3DRD1, HTR2A
28amyotrophic lateral sclerosis13.3BDNF, APP, PSEN1, CHAT, CDK5, TSPO
29arthritis13.3PDYN
30breast cancer13.3CDK5, CDK5R1
31dementia13.3ITIH4, CHAT, TRH, ACHE, TSPO, PSEN1
32drug dependence13.3PDYN
33encephalitis13.3CALB1, PDYN, APP, ITIH4, TSPO
34epilepsy syndrome13.3BDNF, FMR1, CALB1, PDYN, HTR1A, GRIN1
35focal epilepsy13.3TSPO, PDYN
36herpes simplex13.3CDK5, GRIN1, CALB1, BDNF
37hypertrophy of breast13.3BDNF, PDYN, HTR1A, CHAT, ACHE
38hypothyroidism13.3FMR1, TRH
39ischemia13.3CDK5, BDNF, PDYN, HTR1A, PSEN1, CHAT
40leukemia13.3ITIH4, CHAT, CDK5R1, CDK5, ACHE
41malignant glioma13.3HTR1A, HTR2A, APP, PSEN1, ITIH4, CHAT
42migraine13.3HTR1A, HTR2A, DRD1
43mood disorder13.3BDNF, PDYN, HTR1A, HTR2A, DRD1, GRIN1
44motor neuron disease13.3CDK5, BDNF
45multiple system atrophy13.3FMR1, CHAT, CDK5, TSPO
46psychotic disorder13.3BDNF, PDYN, HTR1A, HTR2A, PSEN1, DRD1
47schizophrenia13.3BDNF, TSPO, FMR1, CALB1, PDYN, HTR1A
48developmental disabilities13.3BDNF, FMR1, HTR1A
49pheochromocytoma13.3PDYN, APP, PSEN1, CHAT
50mental retardation13.3HSD17B10, BDNF, FMR1, APP

Graphical network of the top 20 diseases related to Memory Impairment:



Diseases related to memory impairment

Clinical Features for Memory Impairment

Drugs & Therapeutics for Memory Impairment

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Memory Impairment

Drug clinical trials:

Search ClinicalTrials for Memory Impairment

Search NIH Clinical Center for Memory Impairment

Search CenterWatch for Memory Impairment

Genetic Tests for Memory Impairment

Anatomical Context for Memory Impairment

Sources:
33MalaCards
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MalaCards organs/tissues related to Memory Impairment:

33
Bone marrow, Brain, Cortex, Kidney, Breast, Skin, T cells, B lymphoblasts, B cells, Fetal brain, Prefrontal cortex, Parietal lobe, Temporal lobe, Thalamus

Animal Models for Memory Impairment or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Memory Impairment

Sources:
51PubMed
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Articles related to Memory Impairment:

(show top 50)    (show all 627)
idTitleAuthorsYear
1
Gray matter atrophy pattern in elderly with subjective memory impairment. (23867795)
2014
2
Hydrogen sulfide improves spatial memory impairment and decreases production of AI^ in APP/PS1 transgenic mice. (24412510)
2014
3
Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer's disease. (23900282)
2013
4
The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice. (24008687)
2013
5
Treadmill exercise alleviates post-traumatic stress disorder-induced impairment of spatial learning memory in rats. (24278894)
2013
6
Hilar interneuron vulnerability distinguishes aged rats with memory impairment. (23749483)
2013
7
Neuropsychological detection of the early stage of amnestic mild cognitive impairment without objective memory impairment. (23392179)
2013
8
Synaptic plasticity alterations associated with memory impairment induced by deletion of CB2 cannabinoid receptors. (23796670)
2013
9
Spatial working memory impairment in subclinical hypothyroidism: an FMRI study. (22986643)
2013
10
Patterns of prospective memory impairment among individuals with depression: the influence of cue type and delay interval. (23469920)
2013
11
Molecular mechanisms involved in interleukin 1-beta (IL-1I^)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (I+-MSH). (23968970)
2013
12
Neonatal Hypoxia, Hippocampal Atrophy, and Memory Impairment: Evidence of a Causal Sequence. (24343890)
2013
13
Memory impairment associated with varenicline: a case series from the New Zealand Intensive Medicines Monitoring Programme. (23232978)
2013
14
Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome. (23742761)
2013
15
Krill-Derived Phosphatidylserine Improves TMT-Induced Memory Impairment in the Rat. (24116297)
2012
16
The effect of treatment with a sustained-release prostacyclin analogue (ONO-1301-loaded PLGA microsphere) on short-term memory impairment in rats with transient global cerebral ischemia. (22360765)
2012
17
Memory impairment induced by brain iron overload is accompanied by reduced H3K9 acetylation and ameliorated by sodium butyrate. (22067609)
2012
18
Scopolamine induced memory impairment; possible involvement of NMDA receptor mechanisms of dorsal hippocampus and/or septum. (22421366)
2012
19
Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. (22339795)
2012
20
Working memory impairment in fibromyalgia patients associated with altered frontoparietal memory network. (22715371)
2012
21
Verbal and nonverbal memory impairment in aphasia. (22258478)
2012
22
Extended retention intervals can help to bridge the gap between subjective and objective memory impairment. (22119172)
2012
23
Watermaze performance after middle cerebral artery occlusion in the rat: the role of sensorimotor versus memory impairments. (22373646)
2012
24
Time perception disorders are related to working memory impairment in schizophrenia. (22862910)
2012
25
A Model for Mild Traumatic Brain Injury that Induces Limited Transient Memory Impairment and Increased Levels of Axon Related Serum Biomarkers. (22837752)
2012
26
Memory complaints with and without memory impairment: the impact of leukoaraiosis on cognition. (21923974)
2011
27
Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil. (22114680)
2011
28
Antiretroviral adherence and the nature of HIV-associated verbal memory impairment. (21948894)
2011
29
Memory impairment associated with neurometabolic abnormalities of the hippocampus in patients with non-neuropsychiatric systemic lupus erythematosus. (21335397)
2011
30
Introduction to the special issue of Neurobiology of Learning and Memory on memory impairment and disease. (21945881)
2011
31
Memory Impairment and Executive Dysfunction are Associated with Inadequately Controlled Diabetes in Older Adults. (23804840)
2011
32
Objective and subjective memory impairment in elderly adults: a revised version of the Everyday Memory Questionnaire. (21499021)
2011
33
The role of histone acetylation in age-associated memory impairment and Alzheimer's disease. (21540120)
2011
34
A selective working memory impairment after transcranial direct current stimulation to the right parietal lobe. (20570713)
2010
35
Cerebrovascular hypoperfusion induces spatial memory impairment, synaptic changes, and amyloid-I^ oligomerization in rats. (20634588)
2010
36
Why Alzheimer's Disease Starts with a Memory Impairment: Neurophysiological Insight. (20061617)
2010
37
Chronic intermittent hypoxia exposure induces memory impairment in growing rats. (20871647)
2010
38
Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment. (20368517)
2010
39
Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice. (20380820)
2010
40
HIV-associated episodic memory impairment: evidence of a possible differential deficit in source memory for complex visual stimuli. (19622690)
2009
41
Commentary: Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT2A levels. (18544454)
2008
42
Differential CSF biomarker levels in APOE-epsilon4-positive and -negative patients with memory impairment. (17124416)
2007
43
Primary and secondary anosognosia for memory impairment in patients with Alzheimer's disease. (17941357)
2007
44
Impairment of executive function but not memory in first-degree relatives of patients with bipolar I disorder and in euthymic patients with unipolar depression. (16199852)
2005
45
Presenilin-1 mutation sensitizes oligodendrocytes to glutamate and amyloid toxicities, and exacerbates white matter damage and memory impairment in mice. (12665676)
2003
46
Apolipoprotein E gender effects on cognitive performance in age-associated memory impairment. (11884660)
2002
47
MRI and genetic correlates of cognitive function in elders with memory impairment. (11378252)
2001
48
Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. (9918593)
1999
49
Persistent memory impairment following transient global amnesia. (2286654)
1990
50
Basal nucleus lesions in monkeys: recognition memory impairment or visual agnosia? (3137613)
1988

Genetic Variations for Memory Impairment

Expression for genes affiliated with Memory Impairment

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Memory Impairment

Search GEO for disease gene expression data for Memory Impairment.

Pathways for genes affiliated with Memory Impairment

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB, 4Cell Signaling Technology, 54Reactome
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Pathways related to Memory Impairment according to GeneCards/GeneDecks:

(show top 18)    (show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4BDNF
210.4BDNF
310.4BDNF
4
Hide members
10.4BDNF
5
Hide members
10.3BDNF, PSEN1
610.3ACHE, CHAT
710.3ACHE, CHAT
810.3TSPO, HTR1A
910.3APOE, APP
10
Hide members
10.3APP, PSEN1
11
Hide members
10.3HTR2A, HTR1A
1210.2BDNF, APP, PSEN1
1310.2APP, APOE, PSEN1
1410.1HTR1A, APP, APOE, PSEN1
1510.1BDNF, HTR1A, HTR2A, CHAT
16
Hide members
10.0HTR1A, HTR2A, APP, CHAT, ACHE
17
Hide members
10.0HTR1A, HTR2A, APP, APOE, TRH
18
Hide members
10.0HTR1A, HTR2A, APP, TRH, TSPO

Compounds for genes affiliated with Memory Impairment

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
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Compounds related to Memory Impairment according to GeneCards/GeneDecks:

(show top 50)    (show all 235)
idCompoundScoreTop Affiliating Genes
1lithium45 50 11 2413.7TRH, BDNF
2methamphetamine45 50 1112.7BDNF, CHAT
3mptp4510.7BDNF, TSPO
46-hydroxydopamine4510.6APP, CHAT, BDNF
5morphine45 50 29 1113.6ITIH4, TRH, TSPO
6oligonucleotide4510.6PSEN1, CHAT, TRH
7gnrh4510.6BDNF, TRH
8levodopa45 1111.5TRH, BDNF, TSPO, HTR1A
9estrogen4510.5CHAT, TRH
10pramipexole45 50 29 1113.5BDNF, HTR2A, HTR1A
11atropine45 29 1112.5ACHE, TRH, APP
12opiate4510.5ITIH4, TSPO, APP
13ketanserin29 4511.5BDNF, HTR2A, HTR1A
14quinolinic acid45 2411.5BDNF, ITIH4, CHAT
15kainate45 2911.5APOE, BDNF, PSEN1, CHAT, TSPO
16apomorphine45 29 1112.5CHAT, HTR1A, HTR2A, TRH
17imipramine45 50 29 11 2414.5CHAT, HTR2A, HTR1A, BDNF
18scopolamine45 29 11 2413.5ACHE, TSPO, CHAT, HTR1A
19cocaine45 1111.5BDNF, ITIH4, CHAT, TSPO, TRH
20gaba4510.4BDNF, CHAT, TRH, TSPO, APP
21donepezil45 11 2412.4HTR2A, APP, APOE, CHAT, ACHE
22olanzapine50 45 29 11 2414.4BDNF, CHAT, HTR2A, HTR1A, APOE
23huperzine a4510.4ACHE, CHAT, APP
24risperidone29 45 50 60 11 2415.4HTR1A, BDNF, CHAT, HTR2A, APP
25fluvoxamine45 50 1112.4HTR2A, TSPO, BDNF, HTR1A
26glutamine4510.4PSEN1, APOE, APP, TSPO, ITIH4
27choline45 11 2412.4BDNF, ACHE, APP, PSEN1, CHAT
28(+)-butaclamol29 4511.4HTR1A, HTR2A
29metrifonate4510.4ACHE, APOE, APP
305-hydroxytryptamine4510.4HTR1A, APP, HTR2A, TSPO, CHAT
31nicotine45 50 29 1113.4ACHE, TSPO, APP, ITIH4, CHAT, APOE
32ginkgo4510.4ACHE, TSPO, APP
33haloperidol45 29 2 50 1114.3HTR2A, BDNF, CHAT, TRH, TSPO, HTR1A
34testosterone45 60 11 2413.3BDNF, CHAT, APOE, TSPO, TRH, APP
35calcium45 50 11 2413.3CHAT, TRH, HTR2A, PSEN1, BDNF
36spec-t4510.3APOE, PSEN1, TSPO
37arginine4510.3ITIH4, TRH, PSEN1, TSPO, APOE, APP
38lipid4510.3TRH, CHAT, APOC1, APOE, APP, PSEN1
39valine4510.3BDNF, APP, TSPO, APOE, PSEN1, ITIH4
40glucose4510.3TRH, APOC1, CHAT, PSEN1, BDNF
41corticosterone45 60 2412.2BDNF, APP, ITIH4, TSPO, HTR1A
42quetiapine45 50 29 11 2414.2BDNF, HTR2A, HTR1A
43serine4510.2APP, PSEN1, ACHE
44acetylcholine45 50 29 11 2414.2TSPO, ACHE, TRH, CHAT, APOE, APP
45Thioproperazine1110.2HTR1A, HTR2A
46norepinephrine45 11 2412.2BDNF, HTR1A, TSPO, TRH, CHAT, PSEN1
47nmda45 2911.1BDNF, HTR1A, TSPO, ACHE, CHAT, ITIH4
48glutamate4510.1PSEN1, APOE, APP, BDNF, ITIH4, CHAT
49dopamine45 29 11 2413.0TSPO, ACHE, HTR1A, HTR2A, APP, APOE
50Acepromazine1110.0HTR1A, HTR2A

GO Terms for genes affiliated with Memory Impairment

Sources:
16Gene Ontology
See all sources

Cellular components related to Memory Impairment according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase 5 holoenzyme complexGO:01653310.7
2dendritic spineGO:04319710.6APP
3dendriteGO:03042510.6APOE, ACHE
4neuromuscular junctionGO:03159410.5APP, PSEN1, ACHE
5synapseGO:04520210.5APP, ACHE
6neuronal cell bodyGO:04302510.5APOE, PSEN1, CHAT
7dendritic shaftGO:04319810.5HTR2A, APP, PSEN1
8growth coneGO:03042610.5PSEN1
9ciliary rootletGO:03525310.4APP, PSEN1
10chylomicronGO:04262710.3APOC1, APOE
11axonGO:03042410.3ACHE, HTR2A, APP, PSEN1, CHAT
12perinuclear region of cytoplasmGO:04847110.3BDNF, APP, PSEN1, ACHE
13postsynaptic densityGO:01406910.2
14integral to plasma membraneGO:00588710.1HTR2A, APP, PSEN1, HTR1A
15plasma membraneGO:00588610.1HTR1A, HTR2A, APP, APOE, ITIH4, TRH
16extracellular regionGO:0055769.8BDNF, APP, APOE, ITIH4, TRH, ACHE

Biological processes related to Memory Impairment according to GeneCards/GeneDecks:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1serine phosphorylation of STAT3 proteinGO:03313610.9
2conditioned taste aversionGO:00166110.9
3regulation of excitatory postsynaptic membrane potentialGO:06007910.8BDNF
4regulation of dendritic spine morphogenesisGO:06100110.8
5visual learningGO:00854210.8APP
6ionotropic glutamate receptor signaling pathwayGO:03523510.8APP
7regulation of synaptic plasticityGO:04816710.8PSEN1
8layer formation in cerebral cortexGO:02181910.8
9negative regulation of axon extensionGO:03051710.8
10synapse assemblyGO:00741610.8ACHE
11sensory perception of painGO:01923310.8HTR2A
12behavioral fear responseGO:00166210.8BDNF, HTR1A
13synaptic transmission, dopaminergicGO:00196310.7
14mating behaviorGO:00761710.7APP
15very-low-density lipoprotein particle clearanceGO:03444710.7APOC1, APOE
16regulation of dopamine metabolic processGO:04205310.7HTR1A
17behavioral response to cocaineGO:04814810.7
18smooth endoplasmic reticulum calcium ion homeostasisGO:05156310.7PSEN1, APP
19neuron apoptotic processGO:05140210.7APP, PSEN1
20neuron projection developmentGO:03117510.7APP
21regulation of cholesterol transportGO:03237410.7APOC1, TSPO
22regulation of hormone secretionGO:04688310.7HTR2A, HTR1A
23adult walking behaviorGO:00762810.7CHAT, TRH
24chylomicron remnant clearanceGO:03438210.7APOC1, APOE
25peripheral nervous system axon regenerationGO:01401210.7APOE, TSPO
26positive regulation of cholesterol esterificationGO:01087310.7APOE, APOC1
27memoryGO:00761310.7PSEN1, HTR2A
28prepulse inhibitionGO:06013410.7
29negative regulation of neuron apoptotic processGO:04352410.7PSEN1, APOE, BDNF
30positive regulation of protein targeting to membraneGO:09031410.7
31synaptic transmissionGO:00726810.6HTR2A, CHAT, ACHE
32dendrite developmentGO:01635810.6CHAT, APP, BDNF
33cell proliferationGO:00828310.6HTR1A, ACHE, TSPO
34phospholipid effluxGO:03370010.6APOE, APOC1
35cellular calcium ion homeostasisGO:00687410.6HTR2A, APOE
36response to ethanolGO:04547110.6TRH, APOE
37cholesterol metabolic processGO:00820310.6APOC1, APOE, APP
38serotonin receptor signaling pathwayGO:00721010.6HTR1A, HTR2A
39regulation of behaviorGO:05079510.5HTR2A, HTR1A
40suckling behaviorGO:00196710.5APP
41high-density lipoprotein particle remodelingGO:03437510.5APOE, APOC1
42neuron migrationGO:00176410.5PSEN1
43agingGO:00756810.4HTR2A, APOE, TSPO
44regulation of dendrite morphogenesisGO:04881410.4ACHE
45synaptic transmission, cholinergicGO:00727110.3APOE, ACHE
46oligodendrocyte differentiationGO:04870910.3APOE
47neurotransmitter biosynthetic processGO:04213610.0CHAT, ACHE

Molecular functions related to Memory Impairment according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylcholine-sterol O-acyltransferase activator activityGO:06022810.0APOC1, APOE
2protein bindingGO:0055159.9HTR1A, APP, APOE, PSEN1, ITIH4, ACHE

Products for genes affiliated with Memory Impairment

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  • Proteins
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  • Antibodies

Sources for Memory Impairment

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet