MCID: MMR004
MIFTS: 41

Memory Impairment malady

Summaries for Memory Impairment

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63Wikipedia, 32MalaCards
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Wikipedia:63 Amnesia (from Greek ἀμνησία from ἀ- meaning \"without\" and μνήμη memory) is a deficit in... more...

MalaCards: Memory Impairment is related to alzheimer's disease and dementia. An important gene associated with Memory Impairment is BDNF (brain-derived neurotrophic factor), and among its related pathways are Erythropoietin Pathway and Alcoholism. The compounds lithium and methamphetamine have been mentioned in the context of this disorder. Affiliated tissues include brain and temporal lobe, and related mouse phenotypes are integument and respiratory system.

Aliases & Classifications for Memory Impairment

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46OMIM, 44Novoseek, 60UMLS
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Aliases & Descriptions:

memory impairment 46 44 60


Related Diseases for Memory Impairment

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17GeneCards, 18GeneDecks
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Diseases related to Memory Impairment via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1alzheimer's disease36.1HSD17B10, BDNF, CALB1, PDYN, HTR1A, HTR2A
2dementia35.9ITIH4, CHAT, TRH, ACHE, TSPO, PSEN1
3schizophrenia35.7BDNF, TSPO, FMR1, CALB1, PDYN, HTR1A
4ischemia35.7CDK5, BDNF, PDYN, HTR1A, PSEN1, CHAT
5temporal lobe epilepsy35.3BDNF, CALB1, PDYN, HTR1A, GRIN1, TSPO
6parkinson's disease35.0BDNF, FMR1, CALB1, PDYN, HTR1A, HTR2A
7obsessive-compulsive disorder35.0BDNF, PDYN, HTR1A, HTR2A, DRD1, TSPO
8focal epilepsy35.0TSPO, PDYN
9attention deficit hyperactivity disorder34.8DRD1, HTR2A, BDNF
10lewy body dementia34.8ACHE, CDK5, APOE, APP
11cadasil34.8HTR1A, HTR2A, APOE, PSEN1, CHAT, TRH
12breast cancer34.8CDK5, CDK5R1
13encephalitis34.8CALB1, PDYN, APP, ITIH4, TSPO
14herpes simplex34.8CDK5, GRIN1, CALB1, BDNF
15hypothyroidism34.8FMR1, TRH
16leukemia34.8ITIH4, CHAT, CDK5R1, CDK5, ACHE
17mood disorder34.8BDNF, PDYN, HTR1A, HTR2A, DRD1, GRIN1
18tauopathy34.8CDK5, PSEN1, APP
19multiple sclerosis30.7BDNF, APOE, TSPO
20vascular dementia30.4APOE
21brain disease30.3APP, PSEN1, ITIH4, CHAT, TSPO
22diabetes mellitus30.1APOE
23bipolar disorder30.1BDNF, HTR1A
24cerebrovascular disease30.1APP, APOE, TRH, ACHE, TSPO
25status epilepticus29.9BDNF
26frontotemporal dementia29.9APP, APOE, PSEN1, ACHE
27pick's disease29.9APP, APOE, PSEN1, CHAT, ACHE
28obesity29.9HTR1A, HTR2A, APOE, APOC1, TRH
29schizoaffective disorder29.9HTR2A, BDNF
30cholera13.3ACHE, TRH, CHAT, DRD1, HTR1A
31narcolepsy13.3DRD1, HTR2A
32autistic disorder13.3FMR1, BDNF
33huntington's disease13.3BDNF, CALB1, APP, PSEN1, DRD1, CHAT
34gilles de la tourette syndrome13.3HTR1A, HTR2A, DRD1
35sudden infant death syndrome13.3HTR1A, HTR2A, CHAT, GRIN1
36toxic encephalopathy13.3BDNF, APP, CHAT, CDK5
37ganglioglioma13.3GRIN1
38cocaine dependence13.3PDYN
39down syndrome13.3FMR1, HTR1A, APP, APOE, PSEN1, CHAT
40alcohol dependence13.3DRD1, HTR2A
41amyotrophic lateral sclerosis13.3BDNF, APP, PSEN1, CHAT, CDK5, TSPO
42arthritis13.3PDYN
43drug dependence13.3PDYN
44epilepsy syndrome13.3BDNF, FMR1, CALB1, PDYN, HTR1A, GRIN1
45hypertrophy of breast13.3BDNF, PDYN, HTR1A, CHAT, ACHE
46malignant glioma13.3HTR1A, HTR2A, APP, PSEN1, ITIH4, CHAT
47migraine13.3HTR1A, HTR2A, DRD1
48motor neuron disease13.3CDK5, BDNF
49multiple system atrophy13.3FMR1, CHAT, CDK5, TSPO
50psychotic disorder13.3BDNF, PDYN, HTR1A, HTR2A, PSEN1, DRD1

Graphical network of the top 20 diseases related to Memory Impairment:



Diseases related to memory impairment

Clinical Features for Memory Impairment

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Drugs & Therapeutics for Memory Impairment

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Memory Impairment

Drug clinical trials:

Search ClinicalTrials for Memory Impairment

Search NIH Clinical Center for Memory Impairment

Search CenterWatch for Memory Impairment

Genetic Tests for Memory Impairment

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Anatomical Context for Memory Impairment

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32MalaCards
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MalaCards organs/tissues related to Memory Impairment:

32
Brain, Temporal lobe

Animal Models for Memory Impairment or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Memory Impairment:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.3BDNF, APP, APOE, PSEN1
2MP:000538810.3BDNF, APOE, PSEN1, ACHE
3MP:000537710.2APOE, ACHE, BDNF
4MP:000287310.2BDNF, APP, PSEN1, ITIH4, CHAT
5MP:000537810.1APOE, APP, BDNF, PSEN1, ACHE, TRH
6MP:000539110.1BDNF, APOE, PSEN1, ACHE
7MP:000538910.0BDNF, APP, APOE, PSEN1, CHAT, ACHE
8MP:000538610.0ACHE, BDNF, HTR1A, HTR2A, APP, APOE
9MP:000363110.0APP, HTR1A, BDNF, APOE, PSEN1, ACHE
10MP:00053699.9HTR2A, APP, APOE, PSEN1, CHAT, ACHE
11MP:00053769.9BDNF, HTR1A, APP, APOE, APOC1, PSEN1
12MP:00107689.6BDNF, HTR1A, APP, APOE, PSEN1, CHAT

Publications for Memory Impairment

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Genetic Variations for Memory Impairment

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Expression for genes affiliated with Memory Impairment

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Memory Impairment

Search GEO for disease gene expression data for Memory Impairment.

Pathways for genes affiliated with Memory Impairment

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 4Cell Signaling Technology, 53Reactome
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Pathways related to Memory Impairment according to GeneCards/GeneDecks:

(show top 18)    (show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4BDNF
210.4BDNF
310.4BDNF
4
Hide members
10.4BDNF
5
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10.3BDNF, PSEN1
610.3ACHE, CHAT
710.3ACHE, CHAT
810.3TSPO, HTR1A
910.3APOE, APP
10
Hide members
10.3APP, PSEN1
11
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10.3HTR2A, HTR1A
1210.2BDNF, APP, PSEN1
1310.2APP, APOE, PSEN1
1410.1HTR1A, APP, APOE, PSEN1
1510.1BDNF, HTR1A, HTR2A, CHAT
16
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10.0HTR1A, HTR2A, APP, CHAT, ACHE
17
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10.0HTR1A, HTR2A, APP, APOE, TRH
18
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10.0HTR1A, HTR2A, APP, TRH, TSPO

Compounds for genes affiliated with Memory Impairment

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Memory Impairment according to GeneCards/GeneDecks:

(show top 50)    (show all 235)
idCompoundScoreTop Affiliating Genes
1lithium44 49 11 2413.7TRH, BDNF
2methamphetamine44 49 1112.7BDNF, CHAT
3mptp4410.7BDNF, TSPO
46-hydroxydopamine4410.6APP, CHAT, BDNF
5morphine44 49 28 1113.6ITIH4, TRH, TSPO
6oligonucleotide4410.6PSEN1, CHAT, TRH
7gnrh4410.6BDNF, TRH
8levodopa44 1111.5TRH, BDNF, TSPO, HTR1A
9estrogen4410.5CHAT, TRH
10pramipexole44 49 28 1113.5BDNF, HTR2A, HTR1A
11atropine44 28 1112.5ACHE, TRH, APP
12opiate4410.5ITIH4, TSPO, APP
13ketanserin28 4411.5BDNF, HTR2A, HTR1A
14quinolinic acid44 2411.5BDNF, ITIH4, CHAT
15kainate44 2811.5APOE, BDNF, PSEN1, CHAT, TSPO
16apomorphine44 28 1112.5CHAT, HTR1A, HTR2A, TRH
17imipramine44 49 28 11 2414.5CHAT, HTR2A, HTR1A, BDNF
18scopolamine44 28 11 2413.5ACHE, TSPO, CHAT, HTR1A
19cocaine44 1111.5BDNF, ITIH4, CHAT, TSPO, TRH
20gaba4410.4BDNF, CHAT, TRH, TSPO, APP
21donepezil44 11 2412.4HTR2A, APP, APOE, CHAT, ACHE
22olanzapine49 44 28 11 2414.4BDNF, CHAT, HTR2A, HTR1A, APOE
23huperzine a4410.4ACHE, CHAT, APP
24risperidone28 44 49 59 11 2415.4HTR1A, BDNF, CHAT, HTR2A, APP
25fluvoxamine44 49 1112.4HTR2A, TSPO, BDNF, HTR1A
26glutamine4410.4PSEN1, APOE, APP, TSPO, ITIH4
27choline44 11 2412.4BDNF, ACHE, APP, PSEN1, CHAT
28(+)-butaclamol28 4411.4HTR1A, HTR2A
29metrifonate4410.4ACHE, APOE, APP
305-hydroxytryptamine4410.4HTR1A, APP, HTR2A, TSPO, CHAT
31nicotine44 49 28 1113.4ACHE, TSPO, APP, ITIH4, CHAT, APOE
32ginkgo4410.4ACHE, TSPO, APP
33haloperidol44 28 2 49 1114.3HTR2A, BDNF, CHAT, TRH, TSPO, HTR1A
34testosterone44 59 11 2413.3BDNF, CHAT, APOE, TSPO, TRH, APP
35calcium44 49 11 2413.3CHAT, TRH, HTR2A, PSEN1, BDNF
36spec-t4410.3APOE, PSEN1, TSPO
37arginine4410.3ITIH4, TRH, PSEN1, TSPO, APOE, APP
38lipid4410.3TRH, CHAT, APOC1, APOE, APP, PSEN1
39valine4410.3BDNF, APP, TSPO, APOE, PSEN1, ITIH4
40glucose4410.3TRH, APOC1, CHAT, PSEN1, BDNF
41corticosterone44 59 2412.2BDNF, APP, ITIH4, TSPO, HTR1A
42quetiapine44 49 28 11 2414.2BDNF, HTR2A, HTR1A
43serine4410.2APP, PSEN1, ACHE
44acetylcholine44 49 28 11 2414.2TSPO, ACHE, TRH, CHAT, APOE, APP
45Thioproperazine1110.2HTR1A, HTR2A
46norepinephrine44 11 2412.2BDNF, HTR1A, TSPO, TRH, CHAT, PSEN1
47nmda44 2811.1BDNF, HTR1A, TSPO, ACHE, CHAT, ITIH4
48glutamate4410.1PSEN1, APOE, APP, BDNF, ITIH4, CHAT
49dopamine44 28 11 2413.0TSPO, ACHE, HTR1A, HTR2A, APP, APOE
50Acepromazine1110.0HTR1A, HTR2A

GO Terms for genes affiliated with Memory Impairment

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16Gene Ontology
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Cellular components related to Memory Impairment according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase 5 holoenzyme complexGO:01653310.7
2dendritic spineGO:04319710.6APP
3dendriteGO:03042510.6APOE, ACHE
4neuromuscular junctionGO:03159410.5APP, PSEN1, ACHE
5synapseGO:04520210.5APP, ACHE
6neuronal cell bodyGO:04302510.5APOE, PSEN1, CHAT
7dendritic shaftGO:04319810.5HTR2A, APP, PSEN1
8growth coneGO:03042610.5PSEN1
9ciliary rootletGO:03525310.4APP, PSEN1
10chylomicronGO:04262710.3APOC1, APOE
11axonGO:03042410.3ACHE, HTR2A, APP, PSEN1, CHAT
12perinuclear region of cytoplasmGO:04847110.3BDNF, APP, PSEN1, ACHE
13postsynaptic densityGO:01406910.2
14integral to plasma membraneGO:00588710.1HTR2A, APP, PSEN1, HTR1A
15plasma membraneGO:00588610.1HTR1A, HTR2A, APP, APOE, ITIH4, TRH
16extracellular regionGO:0055769.8BDNF, APP, APOE, ITIH4, TRH, ACHE

Biological processes related to Memory Impairment according to GeneCards/GeneDecks:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1serine phosphorylation of STAT3 proteinGO:03313610.9
2conditioned taste aversionGO:00166110.9
3regulation of excitatory postsynaptic membrane potentialGO:06007910.8BDNF
4regulation of dendritic spine morphogenesisGO:06100110.8
5visual learningGO:00854210.8APP
6ionotropic glutamate receptor signaling pathwayGO:03523510.8APP
7regulation of synaptic plasticityGO:04816710.8PSEN1
8layer formation in cerebral cortexGO:02181910.8
9negative regulation of axon extensionGO:03051710.8
10synapse assemblyGO:00741610.8ACHE
11sensory perception of painGO:01923310.8HTR2A
12behavioral fear responseGO:00166210.8BDNF, HTR1A
13synaptic transmission, dopaminergicGO:00196310.7
14mating behaviorGO:00761710.7APP
15very-low-density lipoprotein particle clearanceGO:03444710.7APOC1, APOE
16regulation of dopamine metabolic processGO:04205310.7HTR1A
17behavioral response to cocaineGO:04814810.7
18smooth endoplasmic reticulum calcium ion homeostasisGO:05156310.7PSEN1, APP
19neuron apoptotic processGO:05140210.7APP, PSEN1
20neuron projection developmentGO:03117510.7APP
21regulation of cholesterol transportGO:03237410.7APOC1, TSPO
22regulation of hormone secretionGO:04688310.7HTR2A, HTR1A
23adult walking behaviorGO:00762810.7CHAT, TRH
24chylomicron remnant clearanceGO:03438210.7APOC1, APOE
25peripheral nervous system axon regenerationGO:01401210.7APOE, TSPO
26positive regulation of cholesterol esterificationGO:01087310.7APOE, APOC1
27memoryGO:00761310.7PSEN1, HTR2A
28prepulse inhibitionGO:06013410.7
29negative regulation of neuron apoptotic processGO:04352410.7PSEN1, APOE, BDNF
30positive regulation of protein targeting to membraneGO:09031410.7
31synaptic transmissionGO:00726810.6HTR2A, CHAT, ACHE
32dendrite developmentGO:01635810.6CHAT, APP, BDNF
33cell proliferationGO:00828310.6HTR1A, ACHE, TSPO
34phospholipid effluxGO:03370010.6APOE, APOC1
35cellular calcium ion homeostasisGO:00687410.6HTR2A, APOE
36response to ethanolGO:04547110.6TRH, APOE
37cholesterol metabolic processGO:00820310.6APOC1, APOE, APP
38serotonin receptor signaling pathwayGO:00721010.6HTR1A, HTR2A
39regulation of behaviorGO:05079510.5HTR2A, HTR1A
40suckling behaviorGO:00196710.5APP
41high-density lipoprotein particle remodelingGO:03437510.5APOE, APOC1
42neuron migrationGO:00176410.5PSEN1
43agingGO:00756810.4HTR2A, APOE, TSPO
44regulation of dendrite morphogenesisGO:04881410.4ACHE
45synaptic transmission, cholinergicGO:00727110.3APOE, ACHE
46oligodendrocyte differentiationGO:04870910.3APOE
47neurotransmitter biosynthetic processGO:04213610.0CHAT, ACHE

Molecular functions related to Memory Impairment according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylcholine-sterol O-acyltransferase activator activityGO:06022810.0APOC1, APOE
2protein bindingGO:0055159.9HTR1A, APP, APOE, PSEN1, ITIH4, ACHE

Products for genes affiliated with Memory Impairment

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Sources for Memory Impairment

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet