MCID: MMR004
MIFTS: 50

Memory Impairment malady

Summaries for Memory Impairment

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Amnesia (from Greek ??????? from ?- meaning \"without\" and ????? memory) is a deficit in memory caused... more...

MalaCards: Memory Impairment is related to alzheimer's disease and multiple sclerosis. An important gene associated with Memory Impairment is BDNF (brain-derived neurotrophic factor), and among its related pathways are Statin Pathway and Monoamine GPCRs. The compounds phenylpiperazine and "antivirals for treatment of hiv infections, combinations" have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and testes, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

Aliases & Classifications for Memory Impairment

About this section
Sources:
48OMIM, 46Novoseek, 63UMLS
See all sources

Aliases & Descriptions:

memory impairment 48 46 63


Related Diseases for Memory Impairment

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Memory Impairment via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1alzheimer's disease30.9PSEN1, APOC1, APOE, BDNF, HTR2A, HTR1A
2multiple sclerosis30.8TSPO, APOE, BDNF
3ischemia30.7BDNF, HTR1A, PSEN1
4vascular dementia30.6APOE
5dementia30.6HTR2A, PSEN1, TSPO, APOC1, APOE, HTR1A
6schizophrenia30.6HTR2A, HTR1A, ACHE, TSPO, BDNF, PSEN1
7temporal lobe epilepsy30.4HTR1A, BDNF, TSPO
8bipolar disorder30.3BDNF, HTR1A
9parkinson's disease30.2BDNF, APOE, HTR1A
10cerebrovascular disease30.2TSPO, ACHE, APOE
11obsessive-compulsive disorder30.1BDNF, HTR1A, HTR2A, TSPO
12type 2 diabetes mellitus30.1HTR2A, APOE, ACHE
13schizoaffective disorder30.0HTR2A, BDNF
14fibromyalgia30.0HTR2A, TSPO
15attention deficit hyperactivity disorder30.0HTR2A, BDNF
16mood disorder30.0BDNF, HTR1A, HTR2A
17obesity29.9HTR2A, APOC1, HTR1A, APOE
18vascular disease29.9HTR2A, APOE, PSEN1
19pick's disease29.9PSEN1, APOE, ACHE
20frontotemporal dementia29.9ACHE, PSEN1, APOE
21neuronitis10.6
22cerebritis10.6
23hypoxia10.4
24brain injury10.3
25traumatic brain injury10.3
26semantic dementia10.3
27systemic lupus erythematosus10.2
28lupus erythematosus10.2
29fetal alcohol syndrome10.1
30aphasia10.1
31diabetes mellitus10.1
32focal epilepsy10.1
33transient cerebral ischemia10.1
34hypercholesterolemia10.1
35blindness10.1
36neuroleptic malignant syndrome10.1HTR1A
37endogenous depression10.1BDNF, HTR1A
38generalized anxiety disorder10.1TSPO, HTR1A
39panic disorder10.1TSPO, HTR1A
40bulimia nervosa10.1HTR2A, BDNF
41seasonal affective disorder10.1HTR1A, HTR2A
42gilles de la tourette syndrome10.0HTR2A, HTR1A
43serotonin syndrome10.0HTR1A, HTR2A
44developmental disabilities10.0BDNF, HTR1A
45sudden infant death syndrome10.0HTR2A, HTR1A
46creutzfeldt-jakob disease10.0APOE, TSPO
47central nervous system disease10.0HTR2A, BDNF
48binswanger's disease10.0APOE, ACHE
49progressive supranuclear palsy10.0ACHE, APOE
50lewy body dementia10.0ACHE, APOE

Graphical network of the top 20 diseases related to Memory Impairment:



Diseases related to memory impairment

Symptoms for Memory Impairment

About this section

Drugs & Therapeutics for Memory Impairment

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Memory Impairment

Drug clinical trials:

Search ClinicalTrials for Memory Impairment

Search NIH Clinical Center for Memory Impairment

Search CenterWatch for Memory Impairment

Genetic Tests for Memory Impairment

About this section

Anatomical Context for Memory Impairment

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Memory Impairment:

34
Brain, Temporal lobe, Testes, Eye, Cortex, Prefrontal cortex, Bone, Skin, Caudate nucleus, Thalamus, Breast, Kidney, Parietal lobe

Animal Models for Memory Impairment or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Memory Impairment:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7APOE, BDNF, ACHE, HTR1A
2MP:00053818.3APOE, PSEN1, HTR2A, BDNF
3MP:00053888.2APOE, PSEN1, ACHE, BDNF
4MP:00053918.1ACHE, PSEN1, APOE, BDNF
5MP:00036317.8ACHE, HTR1A, PSEN1, APOE, BDNF
6MP:00053697.7ACHE, HTR2A, PSEN1, APOE
7MP:00053767.5APOC1, PSEN1, HTR1A, ACHE, BDNF, APOE
8MP:00053867.4PSEN1, BDNF, ACHE, HTR1A, APOE, HTR2A

Publications for Memory Impairment

About this section
Sources:
53PubMed
See all sources

Articles related to Memory Impairment:

(show top 50)    (show all 575)
idTitleAuthorsYear
1
Are depressive symptomatology and self-focused attention associated with subjective memory impairment in older adults? (24411288)
2014
2
Withania somnifera root extract ameliorates hypobaric hypoxia induced memory impairment in rats. (23211660)
2013
3
KCNQ channels regulate age-related memory impairment. (23638087)
2013
4
Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats. (23510099)
2013
5
Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain. (24080468)
2013
6
Episodic memory impairment in frontotemporal dementia; a a8^a8^mTc- HMPAO SPECT study. (23016870)
2013
7
Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer's disease. (23900282)
2013
8
The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice. (24008687)
2013
9
Alleviating memory impairment through distraction. (24285905)
2013
10
Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress. (24096214)
2013
11
Effects of different exercise protocols on ethanol-induced spatial memory impairment in adult male rats. (23683528)
2013
12
Melatonin attenuates dexamethasone-induced spatial memory impairment and dexamethasone-induced reduction of synaptic protein expressions in the mouse brain. (24036059)
2013
13
Treadmill and wheel exercise alleviate lipopolysaccharide-induced short-term memory impairment by enhancing neuronal maturation in rats. (23128607)
2013
14
Are cardiovascular risk factors associated with verbal learning and memory impairment in patients with schizophrenia? A cross-sectional study. (23227310)
2012
15
Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia. (22335970)
2012
16
4-O-methylhonokiol prevents memory impairment in the Tg2576 transgenic mice model of Alzheimer's disease via regulation of I^-secretase activity. (22330831)
2012
17
Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats. (22796489)
2012
18
Do Not Respond! Doing the Think/No-Think and Go/No-Go Tasks Concurrently Leads to Memory Impairment of Unpleasant Items during Later Recall. (22870071)
2012
19
Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment. (22914828)
2012
20
Short term stability of verbal memory impairment in mild cognitive impairment and Alzheimer's disease measured using the International Shopping List Test. (22639978)
2012
21
Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates AI^1-42-induced memory impairment in mice. (22829961)
2012
22
Calbindin D28K expression in relation to granule cell dispersion, mossy fibre sprouting and memory impairment in hippocampal sclerosis: a surgical and post mortem series. (21920703)
2012
23
Krill-Derived Phosphatidylserine Improves TMT-Induced Memory Impairment in the Rat. (24116297)
2012
24
The effect of treatment with a sustained-release prostacyclin analogue (ONO-1301-loaded PLGA microsphere) on short-term memory impairment in rats with transient global cerebral ischemia. (22360765)
2012
25
Memory complaints with and without memory impairment: the impact of leukoaraiosis on cognition. (21923974)
2011
26
Pre-dementia memory impairment is associated with white matter tract affection. (21092388)
2011
27
Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL. (20149485)
2011
28
A modified formulation of Chinese traditional medicine improves memory impairment and reduces AI^ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease. (21762767)
2011
29
Systems biology of Alzheimer's disease: how diverse molecular changes result in memory impairment in AD. (21333708)
2011
30
Anesthetic ketamine counteracts repetitive mechanical stress-induced learning and memory impairment in developing mice. (21116850)
2011
31
Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer's disease, 5XFAD. (21770858)
2011
32
Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil. (22114680)
2011
33
Working memory impairment in children with developmental dyslexia: is it just a phonological deficity? (21347921)
2011
34
Anomia as a marker of distinct semantic memory impairments in Alzheimer's disease and semantic dementia. (21443339)
2011
35
Memory impairment in multiple sclerosis and its determinant factors. (21206441)
2011
36
Oxidative imbalance in different neurodegenerative diseases with memory impairment. (20838029)
2011
37
Phytoceramide shows neuroprotection and ameliorates scopolamine-induced memory impairment. (22037667)
2011
38
Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice. (21807074)
2011
39
Destination memory impairment in older people. (20718537)
2010
40
Memory impairment in early sensorimotor deprived rats is associated with suppressed hippocampal neurogenesis and altered CREB signaling. (19891990)
2010
41
NNZ-2591, a novel diketopiperazine, prevented scopolamine-induced acute memory impairment in the adult rat. (20188767)
2010
42
Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis. (20184876)
2010
43
Rescue of Abeta(1-42)-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer's disease. (19393032)
2009
44
Minimizing misdiagnosis: psychometric criteria for possible or probable memory impairment. (19401611)
2009
45
Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors. (19275930)
2009
46
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. (19494151)
2009
47
Transducible P11-CNTF rescues the learning and memory impairments induced by amyloid-beta peptide in mice. (18644361)
2008
48
Concurrent folate treatment prevents Na+,K+-ATPase activity inhibition and memory impairments caused by chronic hyperhomocysteinemia during rat development. (18023318)
2007
49
Reduced short latency afferent inhibition in diffuse axonal injury patients with memory impairment. (16901641)
2006
50
Apolipoprotein E gender effects on cognitive performance in age-associated memory impairment. (11884660)
2002

Variations for Memory Impairment

About this section

Expression for genes affiliated with Memory Impairment

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Memory Impairment

Search GEO for disease gene expression data for Memory Impairment.

Pathways for genes affiliated with Memory Impairment

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 56Reactome, 54QIAGEN, 31KEGG, 5Cell Signaling Technology
See all sources

Compounds for genes affiliated with Memory Impairment

About this section
Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 25HMDB, 12DrugBank, 62Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Memory Impairment according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1phenylpiperazine469.9HTR1A, HTR2A
2antivirals for treatment of hiv infections, combinations529.9APOC1, APOE
3abecarnil469.9HTR1A, TSPO
4urapidil469.9HTR2A, HTR1A
5perospirone469.8HTR2A, HTR1A
6alpha-methylserotonin469.8HTR2A, HTR1A
7ergoline469.8HTR2A, HTR1A
8lysergic acid diethylamide469.8HTR1A, HTR2A
9phenylbiguanide469.8HTR1A, HTR2A
10s 16924309.7HTR1A, HTR2A
11lsd309.7HTR1A, HTR2A
12cinanserin469.7HTR2A, ACHE
13pizotifen30 4610.7HTR2A, HTR1A
14cyamemazine309.7HTR1A, HTR2A
15antidepressants529.6HTR2A, HTR1A, BDNF
16escitalopram46 52 25 1212.6HTR2A, BDNF, HTR1A
17maoa469.6HTR2A, HTR1A, BDNF
18pramipexole46 30 52 1212.6BDNF, HTR2A, HTR1A
19amperozide469.6HTR1A, HTR2A
20ketanserin46 3010.6HTR2A, HTR1A, BDNF
21venlafaxine46 52 25 1212.6HTR2A, BDNF, HTR1A
22nortriptyline52 46 30 1212.6HTR2A, BDNF, HTR1A
23paroxetine46 52 30 1212.6HTR2A, BDNF, HTR1A
24quetiapine46 52 30 25 1213.6BDNF, HTR1A, HTR2A
25chlorpromazine30 46 52 1212.6HTR1A, BDNF, HTR2A
26desipramine46 52 1211.6BDNF, HTR2A, HTR1A
27risperidone46 52 30 62 25 1214.6BDNF, HTR2A, HTR1A
28(tfmpp)469.5HTR1A, HTR2A
29quipazine46 3010.5HTR2A, HTR1A
30fluoxetine46 52 30 1212.5HTR1A, BDNF, HTR2A
31citalopram46 52 25 1212.5HTR2A, HTR1A, BDNF
32buspirone46 30 1211.5HTR1A, TSPO, HTR2A
33clomipramine46 52 1211.5TSPO, HTR2A, HTR1A
34way 100635469.4HTR2A, HTR1A
35imipramine46 30 52 25 1213.4HTR2A, BDNF, HTR1A
36scopolamine46 30 25 1212.4TSPO, ACHE, HTR1A
37diazepam46 30 52 1212.4TSPO, ACHE, BDNF
38donepezil46 52 25 1212.2ACHE, HTR2A, APOE
39fluvoxamine46 52 1211.2TSPO, HTR2A, HTR1A, BDNF
40haloperidol46 52 30 3 1213.2HTR2A, BDNF, HTR1A, TSPO
41olanzapine46 52 30 25 1213.1HTR2A, APOE, BDNF, HTR1A
42spec-t469.1APOE, TSPO, PSEN1
43kainate46 309.8PSEN1, APOE, BDNF, TSPO
44valine468.7BDNF, TSPO, APOE, PSEN1
45tetrodotoxin46 62 3010.7ACHE, APOE, BDNF
46acetylcholine46 52 30 25 1212.6APOE, BDNF, ACHE, HTR1A, TSPO
47norepinephrine46 25 1210.4BDNF, HTR1A, HTR2A, PSEN1, TSPO
48dopamine46 30 25 1211.0BDNF, ACHE, HTR1A, HTR2A, TSPO, APOE
49glutamate468.0PSEN1, APOE, TSPO, ACHE, BDNF
50nmda46 308.8TSPO, APOE, PSEN1, HTR1A, BDNF, ACHE

GO Terms for genes affiliated with Memory Impairment

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Memory Impairment according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:0426279.8APOC1, APOE
2very-low-density lipoprotein particleGO:0343619.7APOE, APOC1
3high-density lipoprotein particleGO:0343649.6APOC1, APOE
4dendritic shaftGO:0431989.0HTR2A, PSEN1
5neuromuscular junctionGO:0315948.7ACHE, PSEN1
6perinuclear region of cytoplasmGO:0484718.7BDNF, ACHE, PSEN1
7axonGO:0304248.7ACHE, HTR2A, PSEN1
8neuronal cell bodyGO:0430258.6APOE, PSEN1, HTR2A

Biological processes related to Memory Impairment according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of cholesterol transportGO:03237410.0TSPO, APOC1
2behavioral fear responseGO:0016629.9BDNF, HTR1A
3very-low-density lipoprotein particle clearanceGO:0344479.9APOC1, APOE
4chylomicron remnant clearanceGO:0343829.9APOC1, APOE
5positive regulation of cholesterol esterificationGO:0108739.9APOC1, APOE
6regulation of hormone secretionGO:0468839.9HTR1A, HTR2A
7phospholipid effluxGO:0337009.9APOE, APOC1
8high-density lipoprotein particle remodelingGO:0343759.9APOC1, APOE
9peripheral nervous system axon regenerationGO:0140129.8APOE, TSPO
10serotonin receptor signaling pathwayGO:0072109.8HTR2A, HTR1A
11regulation of behaviorGO:0507959.8HTR1A, HTR2A
12cholesterol effluxGO:0333449.8APOC1, APOE
13triglyceride metabolic processGO:0066419.8APOE, APOC1
14lipoprotein metabolic processGO:0421579.8APOC1, APOE
15synaptic transmission, cholinergicGO:0072719.6APOE, ACHE
16cellular calcium ion homeostasisGO:0068749.4HTR2A, APOE
17agingGO:0075689.3APOE, TSPO, HTR2A
18cholesterol metabolic processGO:0082039.3APOC1, APOE
19positive regulation of MAP kinase activityGO:0434069.2PSEN1, HTR2A
20memoryGO:0076139.2HTR2A, PSEN1
21positive regulation of catalytic activityGO:0430859.2APOC1, PSEN1
22cell proliferationGO:0082839.1ACHE, HTR1A, TSPO
23negative regulation of neuron apoptotic processGO:0435249.1BDNF, PSEN1, APOE
24synaptic transmissionGO:0072688.9ACHE, HTR2A, TSPO

Molecular functions related to Memory Impairment according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.5APOC1, APOE
2beta-amyloid bindingGO:0015409.3ACHE, APOE
3serotonin receptor activityGO:0049939.2HTR1A, HTR2A

Products for genes affiliated with Memory Impairment

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Memory Impairment

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet