MCID: MMR004
MIFTS: 51

Memory Impairment malady

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Summaries for Memory Impairment

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Wikipedia:65 Amnesia (from Greek ??????? from ?- meaning \"without\" and ????? memory) is a deficit in memory caused... more...

MalaCards based summary: Memory Impairment is related to vascular dementia and multiple sclerosis. An important gene associated with Memory Impairment is BDNF (brain-derived neurotrophic factor), and among its related pathways are Statin Pathway and Monoamine GPCRs. The compounds phenylpiperazine and perospirone have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and testes, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

Aliases & Classifications for Memory Impairment

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Sources:
46OMIM, 44Novoseek, 62UMLS
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Memory Impairment, Aliases & Descriptions:

Name: Memory Impairment 46 44 62


Related Diseases for Memory Impairment

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Diseases related to Memory Impairment via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1vascular dementia31.1APOE
2multiple sclerosis30.8BDNF, TSPO, APOE
3temporal lobe epilepsy30.7TSPO, HTR1A, BDNF
4bipolar disorder30.7HTR1A, BDNF
5ischemia30.6BDNF, HTR1A, PSEN1
6parkinson's disease30.4BDNF, HTR1A, APOE
7schizoaffective disorder30.3HTR2A, BDNF
8fibromyalgia30.3TSPO, HTR2A
9attention deficit hyperactivity disorder30.2HTR2A, BDNF
10cerebrovascular disease30.1APOE, TSPO, ACHE
11mood disorder30.1BDNF, HTR1A, HTR2A
12type 2 diabetes mellitus30.0ACHE, HTR2A, APOE
13obsessive-compulsive disorder29.8TSPO, HTR2A, HTR1A, BDNF
14schizophrenia29.8TSPO, PSEN1, HTR2A, HTR1A, ACHE, BDNF
15obesity29.8HTR1A, HTR2A, APOC1, APOE
16vascular disease29.7APOE, PSEN1, HTR2A
17pick's disease29.7ACHE, PSEN1, APOE
18frontotemporal dementia29.7ACHE, PSEN1, APOE
19alzheimer's disease29.6APOE, APOC1, TSPO, PSEN1, HTR2A, HTR1A
20dementia29.4BDNF, ACHE, HTR1A, HTR2A, PSEN1, TSPO
21neuronitis10.6
22cerebritis10.6
23hypoxia10.5
24neuroleptic malignant syndrome10.4HTR1A
25brain injury10.4
26traumatic brain injury10.4
27endogenous depression10.3HTR1A, BDNF
28semantic dementia10.3
29generalized anxiety disorder10.3TSPO, HTR1A
30panic disorder10.3TSPO, HTR1A
31bulimia nervosa10.2HTR2A, BDNF
32systemic lupus erythematosus10.2
33lupus erythematosus10.2
34transient cerebral ischemia10.2
35seasonal affective disorder10.2HTR2A, HTR1A
36gilles de la tourette syndrome10.2HTR2A, HTR1A
37serotonin syndrome10.2HTR2A, HTR1A
38developmental disabilities10.2BDNF, HTR1A
39creutzfeldt-jakob disease10.2APOE, TSPO
40sudden infant death syndrome10.2HTR2A, HTR1A
41central nervous system disease10.2BDNF, HTR2A
42binswanger's disease10.1APOE, ACHE
43diabetes mellitus10.1
44fetal alcohol syndrome10.1
45aphasia10.1
46encephalitis10.1
47focal epilepsy10.1
48meningitis10.1
49hypercholesterolemia10.1
50blindness10.1

Graphical network of the top 20 diseases related to Memory Impairment:



Diseases related to memory impairment

Symptoms for Memory Impairment

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Drugs & Therapeutics for Memory Impairment

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Drug clinical trials:

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Search NIH Clinical Center for Memory Impairment

Genetic Tests for Memory Impairment

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Anatomical Context for Memory Impairment

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MalaCards organs/tissues related to Memory Impairment:

32
Brain, Temporal lobe, Testes, Cortex, Eye, Prefrontal cortex, Bone, Kidney, Breast, Skin, Parietal lobe, Thalamus, Caudate nucleus

Animal Models for Memory Impairment or affiliated genes

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MGI Mouse Phenotypes related to Memory Impairment:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7BDNF, ACHE, HTR1A, APOE
2MP:00053818.3BDNF, HTR2A, PSEN1, APOE
3MP:00053888.2APOE, PSEN1, ACHE, BDNF
4MP:00053918.1APOE, PSEN1, ACHE, BDNF
5MP:00036317.8BDNF, ACHE, HTR1A, PSEN1, APOE
6MP:00053697.7APOE, PSEN1, HTR2A, ACHE
7MP:00053767.5APOE, APOC1, PSEN1, HTR1A, ACHE, BDNF
8MP:00053867.4BDNF, ACHE, HTR1A, HTR2A, PSEN1, APOE

Publications for Memory Impairment

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Articles related to Memory Impairment:

(show top 50)    (show all 595)
idTitleAuthorsYear
1
Are depressive symptomatology and self-focused attention associated with subjective memory impairment in older adults? (24411288)
2014
2
Withania somnifera root extract ameliorates hypobaric hypoxia induced memory impairment in rats. (23211660)
2013
3
KCNQ channels regulate age-related memory impairment. (23638087)
2013
4
Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats. (23510099)
2013
5
Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain. (24080468)
2013
6
Episodic memory impairment in frontotemporal dementia; a a8^a8^mTc- HMPAO SPECT study. (23016870)
2013
7
Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer's disease. (23900282)
2013
8
The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice. (24008687)
2013
9
Alleviating memory impairment through distraction. (24285905)
2013
10
Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress. (24096214)
2013
11
Effects of different exercise protocols on ethanol-induced spatial memory impairment in adult male rats. (23683528)
2013
12
Melatonin attenuates dexamethasone-induced spatial memory impairment and dexamethasone-induced reduction of synaptic protein expressions in the mouse brain. (24036059)
2013
13
Treadmill and wheel exercise alleviate lipopolysaccharide-induced short-term memory impairment by enhancing neuronal maturation in rats. (23128607)
2013
14
Are cardiovascular risk factors associated with verbal learning and memory impairment in patients with schizophrenia? A cross-sectional study. (23227310)
2012
15
Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia. (22335970)
2012
16
4-O-methylhonokiol prevents memory impairment in the Tg2576 transgenic mice model of Alzheimer's disease via regulation of I^-secretase activity. (22330831)
2012
17
Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats. (22796489)
2012
18
Do Not Respond! Doing the Think/No-Think and Go/No-Go Tasks Concurrently Leads to Memory Impairment of Unpleasant Items during Later Recall. (22870071)
2012
19
Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment. (22914828)
2012
20
Short term stability of verbal memory impairment in mild cognitive impairment and Alzheimer's disease measured using the International Shopping List Test. (22639978)
2012
21
Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates AI^1-42-induced memory impairment in mice. (22829961)
2012
22
Calbindin D28K expression in relation to granule cell dispersion, mossy fibre sprouting and memory impairment in hippocampal sclerosis: a surgical and post mortem series. (21920703)
2012
23
Krill-Derived Phosphatidylserine Improves TMT-Induced Memory Impairment in the Rat. (24116297)
2012
24
The effect of treatment with a sustained-release prostacyclin analogue (ONO-1301-loaded PLGA microsphere) on short-term memory impairment in rats with transient global cerebral ischemia. (22360765)
2012
25
Memory complaints with and without memory impairment: the impact of leukoaraiosis on cognition. (21923974)
2011
26
Pre-dementia memory impairment is associated with white matter tract affection. (21092388)
2011
27
Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL. (20149485)
2011
28
Systems biology of Alzheimer's disease: how diverse molecular changes result in memory impairment in AD. (21333708)
2011
29
Anesthetic ketamine counteracts repetitive mechanical stress-induced learning and memory impairment in developing mice. (21116850)
2011
30
Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer's disease, 5XFAD. (21770858)
2011
31
Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil. (22114680)
2011
32
Working memory impairment in children with developmental dyslexia: is it just a phonological deficity? (21347921)
2011
33
Anomia as a marker of distinct semantic memory impairments in Alzheimer's disease and semantic dementia. (21443339)
2011
34
Memory impairment in multiple sclerosis and its determinant factors. (21206441)
2011
35
Oxidative imbalance in different neurodegenerative diseases with memory impairment. (20838029)
2011
36
Phytoceramide shows neuroprotection and ameliorates scopolamine-induced memory impairment. (22037667)
2011
37
Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice. (21807074)
2011
38
4-O-methylhonokiol attenuated memory impairment through modulation of oxidative damage of enzymes involving amyloid-I^ generation and accumulation in a mouse model of Alzheimer's disease. (21799245)
2011
39
Destination memory impairment in older people. (20718537)
2010
40
Memory impairment in early sensorimotor deprived rats is associated with suppressed hippocampal neurogenesis and altered CREB signaling. (19891990)
2010
41
NNZ-2591, a novel diketopiperazine, prevented scopolamine-induced acute memory impairment in the adult rat. (20188767)
2010
42
Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis. (20184876)
2010
43
Rescue of Abeta(1-42)-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer's disease. (19393032)
2009
44
Minimizing misdiagnosis: psychometric criteria for possible or probable memory impairment. (19401611)
2009
45
Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors. (19275930)
2009
46
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. (19494151)
2009
47
Transducible P11-CNTF rescues the learning and memory impairments induced by amyloid-beta peptide in mice. (18644361)
2008
48
Concurrent folate treatment prevents Na+,K+-ATPase activity inhibition and memory impairments caused by chronic hyperhomocysteinemia during rat development. (18023318)
2007
49
Reduced short latency afferent inhibition in diffuse axonal injury patients with memory impairment. (16901641)
2006
50
Apolipoprotein E gender effects on cognitive performance in age-associated memory impairment. (11884660)
2002

Variations for Memory Impairment

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Expression for genes affiliated with Memory Impairment

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Expression patterns in normal tissues for genes affiliated with Memory Impairment

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Pathways for genes affiliated with Memory Impairment

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Compounds for genes affiliated with Memory Impairment

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Compounds related to Memory Impairment according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1phenylpiperazine449.9HTR1A, HTR2A
2perospirone449.9HTR1A, HTR2A
3antivirals for treatment of hiv infections, combinations509.9APOC1, APOE
4urapidil449.9HTR1A, HTR2A
5abecarnil449.9HTR1A, TSPO
6alpha-methylserotonin449.8HTR2A, HTR1A
7ergoline449.8HTR1A, HTR2A
8lysergic acid diethylamide449.8HTR1A, HTR2A
9phenylbiguanide449.8HTR2A, HTR1A
10(tfmpp)449.7HTR2A, HTR1A
11s 16924289.7HTR1A, HTR2A
12cinanserin449.7HTR2A, ACHE
13pizotifen28 4410.7HTR1A, HTR2A
14cyamemazine289.7HTR1A, HTR2A
15antidepressants509.6HTR2A, HTR1A, BDNF
16escitalopram44 50 24 1112.6HTR2A, BDNF, HTR1A
17maoa449.6HTR2A, HTR1A, BDNF
18pramipexole44 28 50 1112.6BDNF, HTR2A, HTR1A
19amperozide449.6HTR1A, HTR2A
20ketanserin44 2810.6HTR2A, HTR1A, BDNF
21venlafaxine44 50 24 1112.6HTR2A, BDNF, HTR1A
22nortriptyline50 44 28 1112.6HTR2A, BDNF, HTR1A
23paroxetine44 50 28 1112.6BDNF, HTR1A, HTR2A
24quetiapine44 50 28 24 1113.6BDNF, HTR1A, HTR2A
25desipramine44 50 1111.6BDNF, HTR2A, HTR1A
26chlorpromazine28 44 50 1112.6HTR1A, BDNF, HTR2A
27risperidone44 50 28 61 24 1114.6BDNF, HTR1A, HTR2A
28way 100635449.5HTR2A, HTR1A
298-hydroxy-2-(di-n-propylamino)tetralin449.5HTR1A, HTR2A
30fluoxetine44 50 28 1112.5BDNF, HTR1A, HTR2A
31citalopram44 50 24 1112.5HTR1A, BDNF, HTR2A
32buspirone44 28 1111.5HTR1A, TSPO, HTR2A
33clomipramine44 50 1111.5TSPO, HTR2A, HTR1A
34lsd289.4HTR2A, HTR1A
35imipramine44 28 50 24 1113.4HTR2A, BDNF, HTR1A
36scopolamine44 28 24 1112.4TSPO, ACHE, HTR1A
37diazepam44 28 50 1112.4ACHE, BDNF, TSPO
38donepezil44 50 24 1112.2ACHE, HTR2A, APOE
39fluvoxamine44 50 1111.2TSPO, HTR2A, HTR1A, BDNF
40haloperidol44 50 28 2 1113.2HTR2A, BDNF, HTR1A, TSPO
41olanzapine44 50 28 24 1113.1HTR2A, APOE, BDNF, HTR1A
42spec-t449.1PSEN1, APOE, TSPO
43kainate44 289.8PSEN1, APOE, BDNF, TSPO
44valine448.7BDNF, TSPO, APOE, PSEN1
45tetrodotoxin44 61 2810.7APOE, ACHE, BDNF
46acetylcholine44 50 28 24 1112.6APOE, BDNF, ACHE, HTR1A, TSPO
47norepinephrine44 24 1110.4BDNF, HTR1A, HTR2A, PSEN1, TSPO
48dopamine44 28 24 1111.0BDNF, ACHE, HTR1A, HTR2A, TSPO, APOE
49glutamate448.0ACHE, PSEN1, TSPO, APOE, BDNF
50nmda44 288.8TSPO, APOE, PSEN1, HTR1A, BDNF, ACHE

GO Terms for genes affiliated with Memory Impairment

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Cellular components related to Memory Impairment according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:0426279.8APOC1, APOE
2very-low-density lipoprotein particleGO:0343619.7APOE, APOC1
3high-density lipoprotein particleGO:0343649.6APOC1, APOE
4dendritic shaftGO:0431989.0HTR2A, PSEN1
5neuromuscular junctionGO:0315948.7ACHE, PSEN1
6perinuclear region of cytoplasmGO:0484718.7BDNF, ACHE, PSEN1
7axonGO:0304248.7ACHE, HTR2A, PSEN1
8neuronal cell bodyGO:0430258.6APOE, PSEN1, HTR2A

Biological processes related to Memory Impairment according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of cholesterol transportGO:03237410.0TSPO, APOC1
2behavioral fear responseGO:0016629.9BDNF, HTR1A
3very-low-density lipoprotein particle clearanceGO:0344479.9APOC1, APOE
4chylomicron remnant clearanceGO:0343829.9APOC1, APOE
5positive regulation of cholesterol esterificationGO:0108739.9APOC1, APOE
6regulation of hormone secretionGO:0468839.9HTR1A, HTR2A
7phospholipid effluxGO:0337009.9APOE, APOC1
8high-density lipoprotein particle remodelingGO:0343759.9APOC1, APOE
9peripheral nervous system axon regenerationGO:0140129.8APOE, TSPO
10serotonin receptor signaling pathwayGO:0072109.8HTR2A, HTR1A
11regulation of behaviorGO:0507959.8HTR1A, HTR2A
12cholesterol effluxGO:0333449.8APOC1, APOE
13triglyceride metabolic processGO:0066419.8APOE, APOC1
14lipoprotein metabolic processGO:0421579.8APOC1, APOE
15synaptic transmission, cholinergicGO:0072719.6APOE, ACHE
16cellular calcium ion homeostasisGO:0068749.4HTR2A, APOE
17agingGO:0075689.3APOE, TSPO, HTR2A
18cholesterol metabolic processGO:0082039.3APOC1, APOE
19positive regulation of MAP kinase activityGO:0434069.2PSEN1, HTR2A
20memoryGO:0076139.2HTR2A, PSEN1
21positive regulation of catalytic activityGO:0430859.2APOC1, PSEN1
22cell proliferationGO:0082839.1ACHE, HTR1A, TSPO
23negative regulation of neuron apoptotic processGO:0435249.1BDNF, PSEN1, APOE
24synaptic transmissionGO:0072688.9ACHE, HTR2A, TSPO

Molecular functions related to Memory Impairment according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.5APOC1, APOE
2beta-amyloid bindingGO:0015409.3ACHE, APOE
3serotonin receptor activityGO:0049939.2HTR1A, HTR2A

Products for genes affiliated with Memory Impairment

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  • Antibodies
  • Proteins
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Sources for Memory Impairment

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet