MCID: MMR004
MIFTS: 50

Memory Impairment malady

Summaries for Memory Impairment

About this section


Wikipedia:64 Amnesia (from Greek ??????? from ?- meaning \"without\" and ????? memory) is a deficit in memory caused... more...

MalaCards based summary: Memory Impairment is related to vascular dementia and multiple sclerosis. An important gene associated with Memory Impairment is BDNF (brain-derived neurotrophic factor), and among its related pathways are Statin Pathway and Monoamine GPCRs. The compounds phenylpiperazine and "antivirals for treatment of hiv infections, combinations" have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and testes, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

Aliases & Classifications for Memory Impairment

About this section
Sources:
46OMIM, 44Novoseek, 61UMLS
See all sources

Memory Impairment, Aliases & Descriptions:

Name: Memory Impairment 46 44 61


Related Diseases for Memory Impairment

About this section

Diseases related to Memory Impairment via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1vascular dementia31.1APOE
2multiple sclerosis30.8TSPO, APOE, BDNF
3temporal lobe epilepsy30.7HTR1A, BDNF, TSPO
4bipolar disorder30.7BDNF, HTR1A
5ischemia30.6BDNF, HTR1A, PSEN1
6parkinson's disease30.4BDNF, APOE, HTR1A
7schizoaffective disorder30.3HTR2A, BDNF
8fibromyalgia30.3HTR2A, TSPO
9attention deficit hyperactivity disorder30.2HTR2A, BDNF
10cerebrovascular disease30.1TSPO, ACHE, APOE
11mood disorder30.1BDNF, HTR1A, HTR2A
12type 2 diabetes mellitus30.0HTR2A, APOE, ACHE
13obsessive-compulsive disorder29.8BDNF, HTR1A, HTR2A, TSPO
14schizophrenia29.8HTR2A, HTR1A, ACHE, TSPO, BDNF, PSEN1
15obesity29.8HTR2A, APOC1, HTR1A, APOE
16vascular disease29.7HTR2A, APOE, PSEN1
17pick's disease29.7PSEN1, APOE, ACHE
18frontotemporal dementia29.7ACHE, PSEN1, APOE
19alzheimer's disease29.6PSEN1, APOC1, APOE, BDNF, HTR2A, HTR1A
20dementia29.4HTR2A, PSEN1, TSPO, APOC1, APOE, HTR1A
21neuronitis10.6
22cerebritis10.6
23hypoxia10.5
24neuroleptic malignant syndrome10.4HTR1A
25brain injury10.4
26traumatic brain injury10.4
27endogenous depression10.3BDNF, HTR1A
28semantic dementia10.3
29generalized anxiety disorder10.3TSPO, HTR1A
30panic disorder10.3TSPO, HTR1A
31bulimia nervosa10.2HTR2A, BDNF
32seasonal affective disorder10.2HTR1A, HTR2A
33systemic lupus erythematosus10.2
34lupus erythematosus10.2
35transient cerebral ischemia10.2
36gilles de la tourette syndrome10.2HTR2A, HTR1A
37serotonin syndrome10.2HTR1A, HTR2A
38developmental disabilities10.2BDNF, HTR1A
39sudden infant death syndrome10.2HTR2A, HTR1A
40creutzfeldt-jakob disease10.2APOE, TSPO
41central nervous system disease10.2HTR2A, BDNF
42binswanger's disease10.1APOE, ACHE
43diabetes mellitus10.1
44fetal alcohol syndrome10.1
45aphasia10.1
46encephalitis10.1
47focal epilepsy10.1
48meningitis10.1
49hypercholesterolemia10.1
50blindness10.1

Graphical network of the top 20 diseases related to Memory Impairment:



Diseases related to memory impairment

Symptoms for Memory Impairment

About this section

Drugs & Therapeutics for Memory Impairment

About this section

Drug clinical trials:

Search ClinicalTrials for Memory Impairment

Search NIH Clinical Center for Memory Impairment

Genetic Tests for Memory Impairment

About this section

Anatomical Context for Memory Impairment

About this section

MalaCards organs/tissues related to Memory Impairment:

32
Brain, Temporal lobe, Testes, Cortex, Eye, Prefrontal cortex, Bone, Kidney, Breast, Skin, Parietal lobe, Thalamus, Caudate nucleus

Animal Models for Memory Impairment or affiliated genes

About this section

MGI Mouse Phenotypes related to Memory Impairment:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7APOE, BDNF, ACHE, HTR1A
2MP:00053818.3APOE, PSEN1, HTR2A, BDNF
3MP:00053888.2APOE, PSEN1, ACHE, BDNF
4MP:00053918.1ACHE, PSEN1, APOE, BDNF
5MP:00036317.8ACHE, HTR1A, PSEN1, APOE, BDNF
6MP:00053697.7ACHE, HTR2A, PSEN1, APOE
7MP:00053767.5APOC1, PSEN1, HTR1A, ACHE, BDNF, APOE
8MP:00053867.4PSEN1, BDNF, ACHE, HTR1A, APOE, HTR2A

Publications for Memory Impairment

About this section

Articles related to Memory Impairment:

(show top 50)    (show all 595)
idTitleAuthorsYear
1
Are depressive symptomatology and self-focused attention associated with subjective memory impairment in older adults? (24411288)
2014
2
Withania somnifera root extract ameliorates hypobaric hypoxia induced memory impairment in rats. (23211660)
2013
3
KCNQ channels regulate age-related memory impairment. (23638087)
2013
4
Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats. (23510099)
2013
5
Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain. (24080468)
2013
6
Episodic memory impairment in frontotemporal dementia; a a8^a8^mTc- HMPAO SPECT study. (23016870)
2013
7
Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer's disease. (23900282)
2013
8
The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice. (24008687)
2013
9
Alleviating memory impairment through distraction. (24285905)
2013
10
Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress. (24096214)
2013
11
Effects of different exercise protocols on ethanol-induced spatial memory impairment in adult male rats. (23683528)
2013
12
Melatonin attenuates dexamethasone-induced spatial memory impairment and dexamethasone-induced reduction of synaptic protein expressions in the mouse brain. (24036059)
2013
13
Treadmill and wheel exercise alleviate lipopolysaccharide-induced short-term memory impairment by enhancing neuronal maturation in rats. (23128607)
2013
14
Are cardiovascular risk factors associated with verbal learning and memory impairment in patients with schizophrenia? A cross-sectional study. (23227310)
2012
15
Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia. (22335970)
2012
16
4-O-methylhonokiol prevents memory impairment in the Tg2576 transgenic mice model of Alzheimer's disease via regulation of I^-secretase activity. (22330831)
2012
17
Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats. (22796489)
2012
18
Do Not Respond! Doing the Think/No-Think and Go/No-Go Tasks Concurrently Leads to Memory Impairment of Unpleasant Items during Later Recall. (22870071)
2012
19
Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment. (22914828)
2012
20
Short term stability of verbal memory impairment in mild cognitive impairment and Alzheimer's disease measured using the International Shopping List Test. (22639978)
2012
21
Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates AI^1-42-induced memory impairment in mice. (22829961)
2012
22
Calbindin D28K expression in relation to granule cell dispersion, mossy fibre sprouting and memory impairment in hippocampal sclerosis: a surgical and post mortem series. (21920703)
2012
23
Krill-Derived Phosphatidylserine Improves TMT-Induced Memory Impairment in the Rat. (24116297)
2012
24
The effect of treatment with a sustained-release prostacyclin analogue (ONO-1301-loaded PLGA microsphere) on short-term memory impairment in rats with transient global cerebral ischemia. (22360765)
2012
25
Memory complaints with and without memory impairment: the impact of leukoaraiosis on cognition. (21923974)
2011
26
Pre-dementia memory impairment is associated with white matter tract affection. (21092388)
2011
27
Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL. (20149485)
2011
28
Systems biology of Alzheimer's disease: how diverse molecular changes result in memory impairment in AD. (21333708)
2011
29
Anesthetic ketamine counteracts repetitive mechanical stress-induced learning and memory impairment in developing mice. (21116850)
2011
30
Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer's disease, 5XFAD. (21770858)
2011
31
Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil. (22114680)
2011
32
Working memory impairment in children with developmental dyslexia: is it just a phonological deficity? (21347921)
2011
33
Anomia as a marker of distinct semantic memory impairments in Alzheimer's disease and semantic dementia. (21443339)
2011
34
Memory impairment in multiple sclerosis and its determinant factors. (21206441)
2011
35
Oxidative imbalance in different neurodegenerative diseases with memory impairment. (20838029)
2011
36
Phytoceramide shows neuroprotection and ameliorates scopolamine-induced memory impairment. (22037667)
2011
37
Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice. (21807074)
2011
38
4-O-methylhonokiol attenuated memory impairment through modulation of oxidative damage of enzymes involving amyloid-I^ generation and accumulation in a mouse model of Alzheimer's disease. (21799245)
2011
39
Destination memory impairment in older people. (20718537)
2010
40
Memory impairment in early sensorimotor deprived rats is associated with suppressed hippocampal neurogenesis and altered CREB signaling. (19891990)
2010
41
NNZ-2591, a novel diketopiperazine, prevented scopolamine-induced acute memory impairment in the adult rat. (20188767)
2010
42
Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis. (20184876)
2010
43
Rescue of Abeta(1-42)-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer's disease. (19393032)
2009
44
Minimizing misdiagnosis: psychometric criteria for possible or probable memory impairment. (19401611)
2009
45
Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors. (19275930)
2009
46
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. (19494151)
2009
47
Transducible P11-CNTF rescues the learning and memory impairments induced by amyloid-beta peptide in mice. (18644361)
2008
48
Concurrent folate treatment prevents Na+,K+-ATPase activity inhibition and memory impairments caused by chronic hyperhomocysteinemia during rat development. (18023318)
2007
49
Reduced short latency afferent inhibition in diffuse axonal injury patients with memory impairment. (16901641)
2006
50
Apolipoprotein E gender effects on cognitive performance in age-associated memory impairment. (11884660)
2002

Variations for Memory Impairment

About this section

Expression for genes affiliated with Memory Impairment

About this section
Expression patterns in normal tissues for genes affiliated with Memory Impairment

Search GEO for disease gene expression data for Memory Impairment.

Pathways for genes affiliated with Memory Impairment

About this section

Compounds for genes affiliated with Memory Impairment

About this section

Compounds related to Memory Impairment according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1phenylpiperazine449.9HTR1A, HTR2A
2antivirals for treatment of hiv infections, combinations509.9APOC1, APOE
3abecarnil449.9HTR1A, TSPO
4urapidil449.9HTR2A, HTR1A
5perospirone449.8HTR2A, HTR1A
6alpha-methylserotonin449.8HTR2A, HTR1A
7ergoline449.8HTR2A, HTR1A
8lysergic acid diethylamide449.8HTR1A, HTR2A
9phenylbiguanide449.8HTR1A, HTR2A
10s 16924299.7HTR1A, HTR2A
11lsd299.7HTR1A, HTR2A
12cinanserin449.7HTR2A, ACHE
13pizotifen29 4410.7HTR2A, HTR1A
14cyamemazine299.7HTR1A, HTR2A
15antidepressants509.6HTR2A, HTR1A, BDNF
16escitalopram44 50 25 1212.6HTR2A, BDNF, HTR1A
17maoa449.6HTR2A, HTR1A, BDNF
18pramipexole44 29 50 1212.6BDNF, HTR2A, HTR1A
19amperozide449.6HTR1A, HTR2A
20ketanserin44 2910.6HTR2A, HTR1A, BDNF
21venlafaxine44 50 25 1212.6HTR2A, BDNF, HTR1A
22nortriptyline50 44 29 1212.6HTR2A, BDNF, HTR1A
23paroxetine44 50 29 1212.6HTR2A, BDNF, HTR1A
24quetiapine44 50 29 25 1213.6BDNF, HTR1A, HTR2A
25chlorpromazine29 44 50 1212.6HTR1A, BDNF, HTR2A
26desipramine44 50 1211.6BDNF, HTR2A, HTR1A
27risperidone44 50 29 60 25 1214.6BDNF, HTR2A, HTR1A
28(tfmpp)449.5HTR1A, HTR2A
29quipazine44 2910.5HTR2A, HTR1A
30fluoxetine44 50 29 1212.5HTR1A, BDNF, HTR2A
31citalopram44 50 25 1212.5HTR2A, HTR1A, BDNF
32buspirone44 29 1211.5HTR1A, TSPO, HTR2A
33clomipramine44 50 1211.5TSPO, HTR2A, HTR1A
34way 100635449.4HTR2A, HTR1A
35imipramine44 29 50 25 1213.4HTR2A, BDNF, HTR1A
36scopolamine44 29 25 1212.4TSPO, ACHE, HTR1A
37diazepam44 29 50 1212.4TSPO, ACHE, BDNF
38donepezil44 50 25 1212.2ACHE, HTR2A, APOE
39fluvoxamine44 50 1211.2TSPO, HTR2A, HTR1A, BDNF
40haloperidol44 50 29 3 1213.2HTR2A, BDNF, HTR1A, TSPO
41olanzapine44 50 29 25 1213.1HTR2A, APOE, BDNF, HTR1A
42spec-t449.1APOE, TSPO, PSEN1
43kainate44 299.8PSEN1, APOE, BDNF, TSPO
44valine448.7BDNF, TSPO, APOE, PSEN1
45tetrodotoxin44 60 2910.7ACHE, APOE, BDNF
46acetylcholine44 50 29 25 1212.6APOE, BDNF, ACHE, HTR1A, TSPO
47norepinephrine44 25 1210.4BDNF, HTR1A, HTR2A, PSEN1, TSPO
48dopamine44 29 25 1211.0BDNF, ACHE, HTR1A, HTR2A, TSPO, APOE
49glutamate448.0PSEN1, APOE, TSPO, ACHE, BDNF
50nmda44 298.8TSPO, APOE, PSEN1, HTR1A, BDNF, ACHE

GO Terms for genes affiliated with Memory Impairment

About this section

Cellular components related to Memory Impairment according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:0426279.8APOC1, APOE
2very-low-density lipoprotein particleGO:0343619.7APOE, APOC1
3high-density lipoprotein particleGO:0343649.6APOC1, APOE
4dendritic shaftGO:0431989.0HTR2A, PSEN1
5neuromuscular junctionGO:0315948.7ACHE, PSEN1
6perinuclear region of cytoplasmGO:0484718.7BDNF, ACHE, PSEN1
7axonGO:0304248.7ACHE, HTR2A, PSEN1
8neuronal cell bodyGO:0430258.6APOE, PSEN1, HTR2A

Biological processes related to Memory Impairment according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of cholesterol transportGO:03237410.0TSPO, APOC1
2behavioral fear responseGO:0016629.9HTR1A, BDNF
3very-low-density lipoprotein particle clearanceGO:0344479.9APOC1, APOE
4chylomicron remnant clearanceGO:0343829.9APOC1, APOE
5positive regulation of cholesterol esterificationGO:0108739.9APOC1, APOE
6regulation of hormone secretionGO:0468839.9HTR2A, HTR1A
7phospholipid effluxGO:0337009.9APOE, APOC1
8high-density lipoprotein particle remodelingGO:0343759.9APOE, APOC1
9peripheral nervous system axon regenerationGO:0140129.8TSPO, APOE
10serotonin receptor signaling pathwayGO:0072109.8HTR2A, HTR1A
11regulation of behaviorGO:0507959.8HTR2A, HTR1A
12cholesterol effluxGO:0333449.8APOE, APOC1
13triglyceride metabolic processGO:0066419.8APOE, APOC1
14lipoprotein metabolic processGO:0421579.8APOE, APOC1
15synaptic transmission, cholinergicGO:0072719.6ACHE, APOE
16cellular calcium ion homeostasisGO:0068749.4APOE, HTR2A
17agingGO:0075689.3HTR2A, TSPO, APOE
18cholesterol metabolic processGO:0082039.3APOC1, APOE
19positive regulation of MAP kinase activityGO:0434069.2PSEN1, HTR2A
20memoryGO:0076139.2HTR2A, PSEN1
21positive regulation of catalytic activityGO:0430859.2APOC1, PSEN1
22cell proliferationGO:0082839.1TSPO, ACHE, HTR1A
23negative regulation of neuron apoptotic processGO:0435249.1BDNF, APOE, PSEN1
24synaptic transmissionGO:0072688.9TSPO, ACHE, HTR2A

Molecular functions related to Memory Impairment according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.5APOC1, APOE
2beta-amyloid bindingGO:0015409.3ACHE, APOE
3serotonin receptor activityGO:0049939.2HTR1A, HTR2A

Products for genes affiliated with Memory Impairment

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Memory Impairment

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet