MCID: MNR002
MIFTS: 52

Meniere's Disease malady

Summaries for Meniere's Disease

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42NIH Rare Diseases, 33MedlinePlus, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Meniere's disease is a disorder of the inner ear. it can cause severe dizziness, a roaring sound in your ears called tinnitus, hearing loss that comes and goes and the feeling of ear pressure or pain. it usually affects just one ear. it is a common cause of hearing loss. attacks of dizziness may come on suddenly or after a short period of tinnitus or muffled hearing. some people have single attacks of dizziness once in a while. others may have many attacks close together over several days. some people with meniere's disease have "drop attacks" during which the dizziness is so bad they lose their balance and fall. scientists don't yet know the cause. they think that it has to do with the fluid levels or the mixing of fluids in the canals of your inner ear. doctors diagnose it based on a physical exam and your symptoms. a hearing test can check to see how it has affected your hearing. there is no cure. treatments include medicines to control dizziness, limiting salt in your diet, and taking water pills. a device that fits into the outer ear and delivers air pulses to the middle ear can help. severe cases may require surgery. nih: national institute on deafness and other communication disorders

MalaCards: Meniere's Disease, also known as meniere disease, is related to menieres disease and hypoparathyroidism. An important gene associated with Meniere's Disease is COCH (cochlin), and among its related pathways are Classical Kir channels and Regulation of Water Balance by Renal Aquaporins. The compounds hg2+ and pcmbs have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and skin, and related mouse phenotype hearing/vestibular/ear.

NIH Rare Diseases:42 Ménière's disease is an abnormality of the inner ear. signs and symptoms may include disabling vertigo or severe dizziness lasting from minutes to hours; tinnitus or a roaring sound in the ears; fluctuating hearing loss; and the sensation of pressure or pain in the affected ear. a small percentage people have drop attacks, also called spells of tumarkin. the disorder usually affects only one ear and is a common cause of hearing loss. some people develop symptoms in both ears many years after their initial diagnosis. the exact cause of ménière's disease is unknown, but the symptoms are thought to be associated with a change in fluid volume within a portion of the inner ear known as the labyrinth. treatment may include medications or surgery depending on the severity of the condition. last updated: 3/12/2013

Genetics Home Reference:21 Ménière disease is a disorder of the inner ear that affects balance and hearing. This condition is characterized by sudden episodes of extreme dizziness (vertigo), a roaring sound in the ears (tinnitus), a feeling of pressure or fullness in the ears, and fluctuations in hearing. Episodes are often associated with nausea and vomiting, and they can severely disrupt activities of daily living.

Wikipedia:63 Ménière\'s disease /meɪnˈjɛərz/, also called endolymphatic hydrops, is a disorder of the inner ear... more...

Description from OMIM:46 156000

Aliases & Classifications for Meniere's Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 33MedlinePlus, 60UMLS, 48Orphanet, 46OMIM, 34MeSH, 27ICD9CM, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
ménière disease:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

meniere's disease 8 42 21 33
meniere disease 8 42 21 60
ménière disease 21 48 46
ménière's disease 42 21
otogenic vertigo 8 21
ménière's vertigo 21
meniere's syndrome 21
auditory vertigo 21
mnire's vertigo 8
aural vertigo 21


External Ids:

Disease Ontology8 DOID:9849
MeSH34 D008575
ICD9CM27 386.00, 386.0
OMIM46 156000
MESH via Orphanet35 D008575
ICD10 via Orphanet26 H81.0
SNOMED-CT via Orphanet57 13445001
UMLS via Orphanet61 C0025281

Related Diseases for Meniere's Disease

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Meniere's Disease:



Diseases related to meniere's disease

Clinical Features for Meniere's Disease

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Sources:
46OMIM
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Clinical features from OMIM:

156000

Clinical synopsis from OMIM:

156000

Drugs & Therapeutics for Meniere's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Meniere's Disease

Drug clinical trials:

Search ClinicalTrials for Meniere's Disease

Search NIH Clinical Center for Meniere's Disease

Search CenterWatch for Meniere's Disease

Genetic Tests for Meniere's Disease

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Anatomical Context for Meniere's Disease

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32MalaCards
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MalaCards organs/tissues related to Meniere's Disease:

32
Testes, Bone, Skin

Animal Models for Meniere's Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Meniere's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.6AQP5, AQP4, AQP1, OCM2, FBXO2, COCH

Publications for Meniere's Disease

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50PubMed
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Articles related to Meniere's Disease:

(show top 50)    (show all 208)
idTitleAuthorsYear
1
Comparison of intratympanic methylprednisolone and gentamicin for Meniere's disease may be misleading. (23818540)
2013
2
Psychological condition in patients with intractable Meniere's disease. (23675809)
2013
3
Response to: Comparison of intratympanic methylprednisolone and gentamicin for Meniere's disease may be misleading. (23818541)
2013
4
Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere's disease. (23370977)
2013
5
Meniere's disease: a reappraisal supported by a variable latency of symptoms and the MRI visualisation of endolymphatic hydrops. (23418296)
2013
6
Blockage pattern of longitudinal flow in Meniere's disease. (23768054)
2013
7
Dynamics of pure tone audiometry and DPOAE changes induced by glycerol in Meniere's disease. (23233313)
2013
8
Antisecretory factor-inducing therapy improves patient-reported functional levels in Meniere's disease. (24294684)
2013
9
Is allergy related to Meniere's disease? (22457225)
2012
10
Genetic and clinical heterogeneity in Meniere's disease. (22415020)
2012
11
Hearing results and quality of life after streptomycin/dexamethasone perfusion for Meniere's disease. (22183636)
2012
12
Gluten sensitivity in Meniere's disease. (22253033)
2012
13
Comparison of the diagnostic value of 3 T MRI after intratympanic injection of GBCA, electrocochleography, and the glycerol test in patients with Meniere's disease. (22201289)
2012
14
Meniere's disease might be an autoimmune condition? (22306860)
2012
15
Intermittent pressure therapy of intractable Meniere's disease and delayed endolymphatic hydrops using the transtympanic membrane massage device: a preliminary report. (21838607)
2011
16
The association of the plasma vasopressin level during attacks with a prognosis of Meniere's disease. (20053151)
2010
17
A serious refractive multifocal intraocular lens complication in Meniere's disease. (20375750)
2010
18
Genetic investigations of Meniere's disease. (20713249)
2010
19
Hypothetical mechanism for vertigo in Meniere's disease. (20713241)
2010
20
Association of a functional polymorphism of PTPN22 encoding a lymphoid protein phosphatase in bilateral Meniere's disease. (19780033)
2010
21
Medical and noninvasive therapy for Meniere's disease. (20713246)
2010
22
Semi-quantitative evaluation of endolymphatic hydrops by bilateral intratympanic gadolinium-based contrast agent (GBCA) administration with MRI for Meniere's disease. (19363714)
2010
23
Endolymphatic sac shunt, labyrinthectomy, and vestibular nerve section in Meniere's disease. (20713247)
2010
24
Contemporary perspectives on the pathophysiology of Meniere's disease: implications for treatment. (20639763)
2010
25
Normal and vestibular patterns in dynamic posturography in patients with Meniere's disease. (19837379)
2010
26
Histopathological and ultrastructural analysis of vestibular endorgans in Meniere's disease reveals basement membrane pathology. (19493357)
2009
27
Changes in the characteristics of definite Meniere's disease over time in Japan: a long-term survey by the Peripheral Vestibular Disorder Research Committee of Japan, formerly the Meniere's Disease Research Committee of Japan. (18607900)
2009
28
Meniere's disease and middle ear pressure: vestibular function after transtympanic tube placement. (19922090)
2009
29
Poly(ADP-ribose) polymerase-1 (PARP-1) longer alleles spanning the promoter region may confer protection to bilateral Meniere's disease. (19863315)
2009
30
Prognosis of low-tone sudden deafness - does it inevitably progress to Meniere's disease? (18274917)
2008
31
Decision making for solitary vestibular schwannoma and contralateral Meniere's disease. (17848792)
2008
32
Vestibular drop attack secondary to Meniere's disease results from unstable otolithic function. (18607945)
2008
33
Case report: a case of intractable Meniere's disease treated with autogenic training. (18221543)
2008
34
Implication of vibration induced nystagmus in Meniere's disease. (17882583)
2007
35
Meniere's disease: rare or underdiagnosed among Africans. (17610076)
2007
36
Provocation of endolymphatic hydrops with a prick test in Meniere's disease. (17901031)
2007
37
Effects of a single intratympanic gentamicin injection on Meniere's disease. (17882572)
2007
38
Cochlear conductive hearing loss in patients with Meniere's disease. (17483606)
2007
39
Meniett therapy may avoid vestibular neurectomy in disabling Meniere's disease. (17851896)
2007
40
Evolution of audiometric pattern in Meniere's disease: long-term survey of 380 cases evaluated according to the 1995 guidelines of the American Academy of Otolaryngology-Head and Neck Surgery. (16527013)
2006
41
Meniere's disease: prevalence of contralateral ear involvement. (16639274)
2006
42
A Meniere's disease gene linked to chromosome 12p12.3. (16741942)
2006
43
Trends in the diagnosis and the management of Meniere's disease: results of a survey. (15886625)
2005
44
Local overpressure treatment reduces vestibular symptoms in patients with Meniere's disease: a clinical, randomized, multicenter, double-blind, placebo-controlled study. (15699722)
2005
45
What is the effect of dizziness on the quality of life for patients with Meniere's disease? (16366382)
2005
46
Surgical management of special cases of intractable Meniere's disease: unilateral cases with intact canals and bilateral cases. (15174769)
2004
47
Intratympanic corticosteroids for Meniere's disease and vertigo. (15474104)
2004
48
Perilymphatic fistula and Meniere's disease. Clinical series and literature review. (11372926)
2001
49
Acetazolamide in Meniere's disease: evaluation of a new diagnostic test for reversible endolymphatic hydrops. (6813812)
1982
50
Evaluation of vertigo; differential diagnosis of Meniere's disease, acute labyrinthitis, tumors of the cerebellopontine angle and insufficiency of the basilar artery. (13614054)
1958

Genetic Variations for Meniere's Disease

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Expression for genes affiliated with Meniere's Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meniere's Disease

Search GEO for disease gene expression data for Meniere's Disease.

Pathways for genes affiliated with Meniere's Disease

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53Reactome, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Meniere's Disease

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Meniere's Disease according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1hg2+4410.6MIP, AQP1
2pcmbs4410.5MIP, AQP1
3delta-12-pgj24410.5HSPA8, HSPA4
4hgcl24410.5AQP2, AQP1, MIP
5geranylgeranylacetone4410.5HSPA8, HSPA4
6ba2+2810.4KCNJ4, KCNJ14
7cs+2810.4KCNJ4, KCNJ14
8cyclopentenone4410.4HSPA8, HSPA4
9tetraethylammonium44 28 1112.4KCNJ4, MIP, AQP1
10p10755910.4KCNJ9, KCNJ4, KCNJ14
11levcromakalim5910.4KCNJ9, KCNJ4, KCNJ14
12bicarbonate4410.4AQP4, AQP1, MIP
13tertiapin-q5910.4KCNJ9, KCNJ4, KCNJ14
14h+ (extracellular)2810.4KCNJ14, KCNJ4
15vas-a4410.3AQP4, AQP1
16diazoxide44 59 28 1113.3KCNJ9, KCNJ4, KCNJ14
17silver4410.3HSPA8, HSPA4, MIP, AQP1
18cdcl24410.3HSPA4, HSPA8
19chloride4410.3MIP, AQP1, AQP2, AQP4
20glibenclamide44 28 49 5913.3KCNJ14, KCNJ4, KCNJ9
21urea44 11 2412.3HSPA8, MIP, AQP1, AQP2, AQP4
22prostaglandin4410.2AQP2, PTGFR, HSPA4, HSPA8
23mannitol44 1111.2AQP4, AQP1, MIP, HSPA4, HSPA8
24mercury4410.2HSPA4, MIP, AQP1, AQP2, AQP4
25methionine4410.2HSPA8, HSPA4, AQP1, AQP2
26mg2+2810.2KCNJ14, KCNJ4
27hydrogen44 2411.2AQP2, AQP1, MIP, HSPA4, HSPA8
28hg2+2810.1AQP7, MIP, AQP6, AQP1, AQP2, AQP5
29sodium44 2411.1HSPA8, HSPA4, MIP, AQP1, AQP2, AQP4
30cysteine4410.0COCH, HSPA8, MIP, AQP1, AQP2, AQP4
31sodium nitroprusside4410.0AQP1, HSPA4, HSPA8
32magnesium44 11 2411.9AQP2, OCM2, KCNJ14, KCNJ4, KCNJ9
33forskolin44 49 1111.9AQP7, AQP2, AQP1, PTGFR
34steroid449.7HSPA8, HSPA4, PTGFR, AQP1, AQP2
35glycerol44 11 2411.7HSPA8, HSPA4, MIP, AQP6, AQP1, AQP2
36potassium44 11 2411.6HSPA8, HSPA4, KCNJ9, KCNJ4, KCNE3, MIP
37dexamethasone44 49 28 1112.5HSPA4, MIP, AQP1, AQP2, AQP4

GO Terms for genes affiliated with Meniere's Disease

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16Gene Ontology
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Cellular components related to Meniere's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.8KCNJ4, AQP1, AQP2, AQP4
2integral to plasma membraneGO:0058879.2AQP5, AQP4, AQP1, AQP6, PTGFR, MIP
3plasma membraneGO:0058868.9HSPA8, AQP5, AQP4, AQP2, AQP1, PTGFR

Biological processes related to Meniere's Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1renal water transportGO:00309710.4AQP2, AQP1
2multicellular organismal water homeostasisGO:05089110.3AQP4, AQP1
3glycerol transportGO:01579310.3AQP1, AQP2, AQP7
4cellular response to mercury ionGO:07128810.3AQP2, AQP1
5carbon dioxide transportGO:01567010.3AQP1, AQP4, AQP5
6renal water absorptionGO:07029510.3AQP4, AQP7
7odontogenesisGO:04247610.2AQP6, AQP1, AQP5
8pancreatic juice secretionGO:03015710.2AQP5, AQP1
9cellular response to copper ionGO:07128010.1AQP2, AQP1
10excretionGO:00758810.1AQP6, AQP2, AQP4, AQP5, AQP7
11cell volume homeostasisGO:0068849.9AQP1, AQP2
12synaptic transmissionGO:0072689.9KCNJ14, KCNJ4, KCNJ9, HSPA8
13water transportGO:0068339.8AQP7, AQP5, AQP4, AQP2, AQP1, AQP6
14transmembrane transportGO:0550859.8MIP, AQP6, AQP1, AQP2, AQP4, AQP5

Molecular functions related to Meniere's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inward rectifier potassium channel activityGO:00524210.1KCNJ14, KCNJ4
2water transmembrane transporter activityGO:00537210.0AQP1, AQP2, AQP4
3glycerol transmembrane transporter activityGO:0151689.9AQP2, AQP1
4water channel activityGO:0152509.8AQP7, AQP5, AQP1, AQP6, MIP

Products for genes affiliated with Meniere's Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Meniere's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet