MCID: MNR002
MIFTS: 48

Meniere's Disease malady

Categories: Rare diseases, Ear diseases

Aliases & Classifications for Meniere's Disease

Aliases & Descriptions for Meniere's Disease:

Name: Meniere's Disease 12 50 25 41 14 50 25
Meniere Disease 12 50 25 42 69
Otogenic Vertigo 12 25
Meniere's Syndrome 25
Ménière's Vertigo 25
Auditory Vertigo 25
Menieres Disease 52
Mnire's Vertigo 12
Ménière Disease 25
Vertigo, Aural 69
Aural Vertigo 25

Characteristics:

HPO:

32
meniere's disease:
Inheritance autosomal dominant inheritance
Onset and clinical course incomplete penetrance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Ear diseases


External Ids:

Disease Ontology 12 DOID:9849
ICD10 33 H81.0 H81.09
ICD9CM 35 386.0 386.00
MeSH 42 D008575
UMLS 69 C0025281

Summaries for Meniere's Disease

MedlinePlus : 41 meniere's disease is a disorder of the inner ear. it can cause severe dizziness, a roaring sound in your ears called tinnitus, hearing loss that comes and goes and the feeling of ear pressure or pain. it usually affects just one ear. it is a common cause of hearing loss. attacks of dizziness may come on suddenly or after a short period of tinnitus or muffled hearing. some people have single attacks of dizziness once in a while. others may have many attacks close together over several days. some people with meniere's disease have "drop attacks" during which the dizziness is so bad they lose their balance and fall. scientists don't yet know the cause. they think that it has to do with the fluid levels or the mixing of fluids in the canals of your inner ear. doctors diagnose it based on a physical exam and your symptoms. a hearing test can check to see how it has affected your hearing. there is no cure. treatments include medicines to control dizziness, limiting salt in your diet, and taking water pills. a device that fits into the outer ear and delivers air pulses to the middle ear can help. severe cases may require surgery. nih: national institute on deafness and other communication disorders

MalaCards based summary : Meniere's Disease, also known as meniere disease, is related to active cochleovestibular meniere's disease and active vestibular meniere's disease, and has symptoms including vertigo, hearing impairment and tinnitus. An important gene associated with Meniere's Disease is FAM136A (Family With Sequence Similarity 136 Member A), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Nanog in Mammalian ESC Pluripotency. The drugs Dexamethasone and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and skin, and related phenotype is hearing/vestibular/ear.

Disease Ontology : 12 A vestibular disease characterized by vertigo, low-pitched tinnitus and hearing loss.

NIH Rare Diseases : 50 ménière's disease is an abnormality of the inner ear. signs and symptoms may include disabling vertigo or severe dizziness lasting from minutes to hours; tinnitus or a roaring sound in the ears; fluctuating hearing loss; and the sensation of pressure or pain in the affected ear. a small percentage of people have drop attacks. the disorder usually affects only one ear, but some people develop symptoms in both ears many years after their initial diagnosis. although the exact cause of ménière's disease is unknown, the symptoms are thought to be associated with a change in fluid volume within a portion of the inner ear known as the labyrinth. treatment may include medications or surgery depending on the severity of the condition. last updated: 12/21/2016

Wikipedia : 71 Ménière\'s disease (MD) is a disorder of the inner ear that is characterized by episodes of feeling... more...

Related Diseases for Meniere's Disease

Diseases related to Meniere's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
id Related Disease Score Top Affiliating Genes
1 active cochleovestibular meniere's disease 10.9
2 active vestibular meniere's disease 10.9
3 active cochlear meniere's disease 10.9
4 spastic paraplegia 32, autosomal recessive 10.3 COCH FAM136A
5 glossopharyngeal nerve neoplasm 10.3 AQP2 AQP4
6 childhood brainstem astrocytoma 10.2 AQP1 AQP4
7 mixed lacrimal gland cancer 10.2 AQP1 FAM136A
8 superior vena cava syndrome 10.2 AQP1 AQP4
9 hypertrichosis universalis congenita, ambras type 10.2 DTNA FAM136A
10 nijmegen breakage syndrome-like disorder 10.2 DTNA FAM136A
11 kidney leiomyosarcoma 10.2 AQP1 AQP3
12 iida kannari syndrome 10.2 AQP1 AQP2
13 cascade stomach 10.2 AQP1 AQP3
14 ovarian disease 10.2 AQP1 AQP4
15 leiomyoma 10.2 AQP1 AQP4
16 growth hormone insensitivity, partial 10.1 AQP5 MIP
17 charcot-marie-tooth disease 2a2b 10.1 AQP4 MIP
18 ehlers-danlos syndrome, kyphoscoliotic form 10.1 AQP1 AQP4 MIP
19 intestinal disaccharidase deficiency 10.1 AQP2 AQP5 COCH FAM136A
20 niemann-pick disease 10.1 AQP1 AQP4 HLA-DRB1
21 histiocytoid hemangioma 10.1 AQP1 AQP4 MIP
22 learning disability 10.0 HLA-C HLA-DRB1
23 kernicterus due to isoimmunization 10.0 HLA-C HLA-DRB1
24 laryngitis 9.9 AQP1 AQP2 AQP5 COCH FAM136A
25 prediabetes syndrome 9.9 AQP1 AQP2 AQP3 MIP
26 contact lens corneal edema 9.9 AQP3 MIP
27 bickerstaff brainstem encephalitis 9.9 HLA-C HLA-DRB1
28 pseudohypoparathyroidism 9.8 HLA-C HLA-DRB1
29 anaerobic meningitis 9.8 HLA-C HLA-DRB1
30 hepatitis 9.8 HLA-C HLA-DRB1
31 venous insufficiency 9.7
32 hypoparathyroidism 9.7
33 basal cell carcinoma 4 9.6 AQP1 AQP2 AQP3 AQP4 AQP7 MIP
34 urethral gland abscess 8.4 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7

Comorbidity relations with Meniere's Disease via Phenotypic Disease Network (PDN):


Active Vestibular Meniere's Disease Anxiety Disorder
Esophagitis Hypertension, Essential
Hypothyroidism Ischemic Heart Disease
Labyrinthitis Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Meniere's Disease:



Diseases related to Meniere's Disease

Symptoms & Phenotypes for Meniere's Disease

Human phenotypes related to Meniere's Disease:

32
id Description HPO Frequency HPO Source Accession
1 vertigo 32 HP:0002321
2 hearing impairment 32 HP:0000365
3 tinnitus 32 HP:0000360

UMLS symptoms related to Meniere's Disease:


coughing, snoring, vertigo, sore throat, vertigo/dizziness, equilibration disorder

MGI Mouse Phenotypes related to Meniere's Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.02 AQP1 AQP3 AQP4 AQP5 COCH

Drugs & Therapeutics for Meniere's Disease

Drugs for Meniere's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
2
Cisplatin Approved Phase 4 15663-27-1 84093 441203 2767
3
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
4
Betahistine Approved Phase 4,Phase 2 5638-76-6 2366
5
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
6
Nicotinamide Approved, Nutraceutical Phase 4 98-92-0 936
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
8
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
9
Histamine Phosphate Phase 4,Phase 2 51-74-1 65513
10 Dexamethasone acetate Phase 4,Phase 3,Phase 2 1177-87-3
11 glucocorticoids Phase 4,Phase 2,Phase 3
12
protease inhibitors Phase 4
13 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
14 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
15 HIV Protease Inhibitors Phase 4
16 Nicotinic Acids Phase 4
17 Tocopherols Phase 4
18 Tocotrienols Phase 4
19 Trace Elements Phase 4
20 Hormone Antagonists Phase 4,Phase 2,Phase 3
21 Dexamethasone 21-phosphate Phase 4,Phase 3,Phase 2
22 Hormones Phase 4,Phase 2,Phase 3
23 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
25 Vasodilator Agents Phase 4,Phase 2
26 Vitamin B Complex Phase 4
27 Pharmaceutical Solutions Phase 4,Phase 2
28 Vitamins Phase 4
29 Hypolipidemic Agents Phase 4
30 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
31 Antiemetics Phase 4,Phase 2,Phase 3
32 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
33 Lipid Regulating Agents Phase 4
34 Antimetabolites Phase 4,Phase 3
35 Micronutrients Phase 4
36 BB 1101 Phase 4,Phase 3,Phase 2
37 Autonomic Agents Phase 4,Phase 2,Phase 3
38 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
39 Antioxidants Phase 4,Phase 1,Phase 2
40 Folate Nutraceutical Phase 4
41 Tocopherol Nutraceutical Phase 4
42 Tocotrienol Nutraceutical Phase 4
43 Vitamin B3 Nutraceutical Phase 4
44 Vitamin B9 Nutraceutical Phase 4
45
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
46
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
47
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
48
Famciclovir Approved Phase 3 104227-87-4 3324
49 Acyclovir Phase 2, Phase 3
50 Anti-Infective Agents Phase 2, Phase 3

Interventional clinical trials:

(show all 34)
id Name Status NCT ID Phase
1 Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomy Completed NCT00160238 Phase 4
2 Efficacy of Local Overpressure Treatment for Meniere's Disease Completed NCT00831688 Phase 4
3 Effect of Stellate Ganglion Block on Meniere's Disease Completed NCT01574313 Phase 4
4 Isobide Solution and Meniace Tablets Compared to Monotherapy With Meniace Tablets Completed NCT02718846 Phase 4
5 Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone Treatment Completed NCT01372904 Phase 4
6 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease Recruiting NCT02530931 Phase 4
7 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS) Recruiting NCT02529475 Phase 4
8 Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Disease Unknown status NCT01729767 Phase 2, Phase 3
9 Clinical Trial of Traditional Chinese Diaoshi Jifa Therapy of Meniere's Disease Completed NCT01454726 Phase 3
10 Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Disease Completed NCT00802529 Phase 2, Phase 3
11 Study of OTO-104 in Subjects With Unilateral Meniere's Disease Recruiting NCT02717442 Phase 3
12 Study of Lamotrigine to Treat Ménière's Disease Recruiting NCT02158585 Phase 3
13 Study of OTO-104 in Subjects With Unilateral Meniere's Disease Active, not recruiting NCT02612337 Phase 3
14 A 6-Month Extension Study of OTO-104 in Meniere's Disease Enrolling by invitation NCT02768662 Phase 3
15 A 6-Month Extension Study of OTO-104 in Meniere's Disease Enrolling by invitation NCT02706730 Phase 3
16 Caroverin and Inner Ear Diseases Suspended NCT01174979 Phase 3
17 Famvir for Treatment of Hearing in Unilateral Meniere's Disease Terminated NCT01526408 Phase 3
18 OTO-104 for the Treatment of Meniere's Disease Completed NCT01412177 Phase 2
19 Sildenafil For Meniere's Disease Completed NCT00145483 Phase 2
20 A 1-Year Safety Study of OTO-104 in Subjects With Unilateral Meniere's Disease Located in United Kingdom Completed NCT02265393 Phase 2
21 Efficacy and Tolerability Study of Betahistine to Ameliorate Antipsychotic Associated Weight Gain in Adolescents and Young Adults Completed NCT00709202 Phase 2
22 The Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2
23 A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2
24 Latanoprost for the Treatment of Menière's Disease Active, not recruiting NCT01973114 Phase 2
25 Open Label Study of OTO-104 in Subjects With Meniere's Disease Active, not recruiting NCT02740387 Phase 2
26 Study to Evaluate SPI-1005 in Adults With Meniere's Disease Enrolling by invitation NCT02603081 Phase 1, Phase 2
27 OTO-104 for Meniere's Disease Completed NCT01084525 Phase 1
28 Vasopressin and V2 Receptor in Meniere's Disease Completed NCT00599560
29 Effects of Endolymphatic Sac Drainage With Steroids for Meniere’s Disease Completed NCT00500474
30 Magnetic Resonance Imaging Evaluation of Inner Ear Pathology Using Intra-Tympanic Contrast Agent Completed NCT02080312
31 Effectiveness of Betaserc® (Betahistine Dihydrochloride) in Patients With Vestibular Vertigo in Routine Practice Completed NCT01759251
32 Stress Management Therapy for Meniere's Disease Recruiting NCT01099046
33 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Active, not recruiting NCT02309099
34 Unilateral Meniere Disease: Can Double Dose Gadolinium and Delayed Imaging Make the Diagnosis? Withdrawn NCT02371798

Search NIH Clinical Center for Meniere's Disease

Cochrane evidence based reviews: meniere disease

Genetic Tests for Meniere's Disease

Anatomical Context for Meniere's Disease

MalaCards organs/tissues related to Meniere's Disease:

39
Testes, Bone, Skin

Publications for Meniere's Disease

Articles related to Meniere's Disease:

(show top 50) (show all 247)
id Title Authors Year
1
Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere's disease. ( 27876815 )
2017
2
Acupuncture Points Stimulation for Meniere's Disease/Syndrome: A Promising Therapeutic Approach. ( 27547229 )
2016
3
Utilisation of multi-frequency VEMPs improves diagnostic accuracy for Meniere's disease. ( 27422626 )
2016
4
Meniere's disease. ( 27170253 )
2016
5
Endolymphatic space size in patients with Meniere's disease and healthy controls. ( 27080254 )
2016
6
Meniere's disease. ( 27170426 )
2016
7
A thin line between Meniere's disease and spontaneous intracranial hypotension syndrome. ( 26827704 )
2016
8
Repeated courses of intratympanic dexamethasone injection are effective for intractable Meniere's disease. ( 27650470 )
2016
9
Volumetric measurements of the inner ear in patients with Meniere's disease using three-dimensional magnetic resonance imaging. ( 27187035 )
2016
10
HLA-Cw Allele Frequency in Definite Meniere's Disease Compared to Probable Meniere's Disease and Healthy Controls in an Iranian Sample. ( 27602337 )
2016
11
Endolymphatic hydrops in patients with unilateral and bilateral Meniere's disease. ( 27564645 )
2016
12
MRI of endolymphatic hydrops in patients with Meniere's disease: a case-controlled study with a simplified classification based on saccular morphology. ( 27999985 )
2016
13
SLC44A2 single nucleotide polymorphisms, isoforms, and expression: Association with severity of Meniere's disease? ( 27829169 )
2016
14
Treatment of Meniere's disease with intratympanic dexamethazone plus high dosage of betahistine. ( 27178513 )
2016
15
Triple semicircular canal plugging: a novel modality for the treatment of intractable Meniere's disease. ( 27434132 )
2016
16
Steroid injections through the eardrum reduce dizziness in Meniere's disease, study finds. ( 27864211 )
2016
17
Incidence of Hypothyroidism in Meniere's Disease. ( 27437251 )
2016
18
Re: Meniere's disease: Importance of socioeconomic and environmental factors. ( 27038820 )
2016
19
Is gentamycin delivery via sustained-release vehicles a safe and effective treatment for refractory Meniere's disease? A critical analysis of published interventional studies. ( 27623821 )
2016
20
Application of Vestibular Spontaneous Response as a Diagnostic Aid for Meniere's Disease. ( 26334355 )
2015
21
Comparative Study of Endolymphatic Sac Decompression and Vestibular Neurectomy in Intractable Meniere's Disease. ( 25621233 )
2015
22
Sex-specific association of RANTES gene -403 variant in Meniere's disease. ( 24961438 )
2015
23
Effects of posterior tympanotomy with steroids at round window on hearing recovery after revision surgery for intractable Meniere's disease. ( 25762028 )
2015
24
Meniere's disease: histopathology, cytochemistry, and imaging. ( 25766597 )
2015
25
Delayed intravenous contrast-enhanced 3D FLAIR MRI in Meniere's disease: correlation of quantitative measures of endolymphatic hydrops with hearing. ( 25457542 )
2015
26
The correlation between symptoms of definite Meniere's disease and endolymphatic hydrops visualized by magnetic resonance imaging. ( 26333096 )
2015
27
Migraine features in patients with Meniere's disease. ( 26109273 )
2015
28
Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease. ( 26343803 )
2015
29
Diffuse systemic sclerosis presenting as Meniere's disease-like symptoms as part of autoimmune inner ear disease. ( 26040060 )
2015
30
Bilateral Meniere's disease assessed by an inner ear test battery. ( 25649882 )
2015
31
Meniere's disease: importance of socioeconomic and environmental factors. ( 25771842 )
2015
32
A Puzzle of Vestibular Physiology in a Meniere's Disease Acute Attack. ( 26167320 )
2015
33
Intronic Variants in the NFKB1 Gene May Influence Hearing Forecast in Patients with Unilateral Sensorineural Hearing Loss in Meniere's Disease. ( 25397881 )
2014
34
Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere's disease. ( 25305078 )
2014
35
One-third of vertiginous episodes during the follow-up period are caused by benign paroxysmal positional vertigo in patients with Meniere's disease. ( 25166020 )
2014
36
Meniere's disease. ( 25391837 )
2014
37
Three-dimensional cone beam computed tomography imaging of the membranous labyrinth in patients with Meniere's disease. ( 25220723 )
2014
38
Autoimmunity as a Candidate for the Etiopathogenesis of Meniere's Disease: Detection of Autoimmune Reactions and Diagnostic Biomarker Candidate. ( 25330336 )
2014
39
Correction: Effect of Intratympanic Dexamethasone on Controlling Tinnitus and Hearing loss in Meniere's Disease. ( 25320707 )
2014
40
Motion sensitivity and caloric responsiveness in vestibular migraine and Meniere's disease. ( 23818082 )
2013
41
Response to: Comparison of intratympanic methylprednisolone and gentamicin for Meniere's disease may be misleading. ( 23818541 )
2013
42
Tenotomy of the stapedius and tensor tympani muscles reduces subjective dizziness handicap in definite Meniere's disease. ( 23350595 )
2013
43
Long-term results of endolymphatic sac drainage with local steroids for intractable Meniere's disease. ( 23273764 )
2013
44
Results of caloric and sensory organization testing of dynamic posturography in migrainous vertigo: comparison with Meniere's disease and vestibular neuritis. ( 23947606 )
2013
45
Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere's disease. ( 23370977 )
2013
46
Potential application of ocular and cervical vestibular-evoked myogenic potentials in Meniere's disease: a review. ( 23070719 )
2013
47
Antisecretory factor-inducing therapy improves patient-reported functional levels in Meniere's disease. ( 24294684 )
2013
48
Electrocochleography in Meniere's disease: recovery from adaptation of the auditory action potential. ( 23394222 )
2013
49
Association between MIF gene variation and Meniere's disease. ( 23566229 )
2013
50
Familial clustering and genetic heterogeneity in Meniere's disease. ( 23521103 )
2013

Variations for Meniere's Disease

ClinVar genetic disease variations for Meniere's Disease:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 FAM136A NM_032822.2(FAM136A): c.226C> T (p.Gln76Ter) single nucleotide variant Pathogenic rs690016537 GRCh37 Chromosome 2, 70527974: 70527974

Expression for Meniere's Disease

Search GEO for disease gene expression data for Meniere's Disease.

Pathways for Meniere's Disease

Pathways related to Meniere's Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
2
Show member pathways
12.78 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
3
Show member pathways
11.58 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
4 10.92 AQP3 AQP5
5 10.78 AQP2 AQP3 AQP4

GO Terms for Meniere's Disease

Cellular components related to Meniere's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.56 AQP1 AQP2 AQP5 MIP
2 integral component of plasma membrane GO:0005887 9.5 AQP1 AQP2 AQP4 AQP5 AQP7 MIP
3 transport vesicle membrane GO:0030658 9.46 AQP2 HLA-DRB1
4 basolateral plasma membrane GO:0016323 9.46 AQP1 AQP2 AQP3 AQP4
5 basal plasma membrane GO:0009925 9.4 AQP1 AQP5
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.37 HLA-C HLA-DRB1
7 plasma membrane GO:0005886 9.36 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
8 membrane GO:0016020 10.17 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
9 integral component of membrane GO:0016021 10.02 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7

Biological processes related to Meniere's Disease according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.81 AQP2 AQP4 AQP5 MIP
2 excretion GO:0007588 9.56 AQP2 AQP3 AQP5 AQP7
3 camera-type eye morphogenesis GO:0048593 9.55 AQP1 AQP5
4 odontogenesis GO:0042476 9.54 AQP1 AQP3 AQP5
5 cellular response to copper ion GO:0071280 9.52 AQP1 AQP2
6 multicellular organismal water homeostasis GO:0050891 9.49 AQP1 AQP4
7 pancreatic juice secretion GO:0030157 9.48 AQP1 AQP5
8 renal water absorption GO:0070295 9.46 AQP1 AQP3
9 renal water homeostasis GO:0003091 9.46 AQP1 AQP2 AQP3 AQP4
10 carbon dioxide transport GO:0015670 9.43 AQP1 AQP5
11 cellular response to mercury ion GO:0071288 9.4 AQP1 AQP2
12 renal water transport GO:0003097 9.32 AQP1 AQP2
13 glycerol transport GO:0015793 9.26 AQP1 AQP2 AQP3 AQP7
14 water transport GO:0006833 9.17 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
15 transport GO:0006810 10.08 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7

Molecular functions related to Meniere's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.55 AQP1 AQP2 AQP3 AQP4 MIP
2 peptide antigen binding GO:0042605 9.37 HLA-C HLA-DRB1
3 glycerol channel activity GO:0015254 9.32 AQP3 AQP7
4 glycerol transmembrane transporter activity GO:0015168 9.26 AQP1 AQP2
5 water channel activity GO:0015250 9.17 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
6 water transmembrane transporter activity GO:0005372 9.13 AQP1 AQP2 AQP4

Sources for Meniere's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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