MCID: MNR002
MIFTS: 52

Meniere's Disease malady

Summaries for Meniere's Disease

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42NIH Rare Diseases, 33MedlinePlus, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Meniere's disease is a disorder of the inner ear. it can cause severe dizziness, a roaring sound in your ears called tinnitus, hearing loss that comes and goes and the feeling of ear pressure or pain. it usually affects just one ear. it is a common cause of hearing loss. attacks of dizziness may come on suddenly or after a short period of tinnitus or muffled hearing. some people have single attacks of dizziness once in a while. others may have many attacks close together over several days. some people with meniere's disease have "drop attacks" during which the dizziness is so bad they lose their balance and fall. scientists don't yet know the cause. they think that it has to do with the fluid levels or the mixing of fluids in the canals of your inner ear. doctors diagnose it based on a physical exam and your symptoms. a hearing test can check to see how it has affected your hearing. there is no cure. treatments include medicines to control dizziness, limiting salt in your diet, and taking water pills. a device that fits into the outer ear and delivers air pulses to the middle ear can help. severe cases may require surgery. nih: national institute on deafness and other communication disorders

MalaCards: Meniere's Disease, also known as meniere disease, is related to menieres disease and hypoparathyroidism. An important gene associated with Meniere's Disease is COCH (cochlin), and among its related pathways are Classical Kir channels and Regulation of Water Balance by Renal Aquaporins. The compounds hg2+ and pcmbs have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and skin, and related mouse phenotype hearing/vestibular/ear.

NIH Rare Diseases:42 Ménière's disease is an abnormality of the inner ear. signs and symptoms may include disabling vertigo or severe dizziness lasting from minutes to hours; tinnitus or a roaring sound in the ears; fluctuating hearing loss; and the sensation of pressure or pain in the affected ear. a small percentage people have drop attacks, also called spells of tumarkin. the disorder usually affects only one ear and is a common cause of hearing loss. some people develop symptoms in both ears many years after their initial diagnosis. the exact cause of ménière's disease is unknown, but the symptoms are thought to be associated with a change in fluid volume within a portion of the inner ear known as the labyrinth. treatment may include medications or surgery depending on the severity of the condition. last updated: 3/12/2013

Genetics Home Reference:21 Ménière disease is a disorder of the inner ear that affects balance and hearing. This condition is characterized by sudden episodes of extreme dizziness (vertigo), a roaring sound in the ears (tinnitus), a feeling of pressure or fullness in the ears, and fluctuations in hearing. Episodes are often associated with nausea and vomiting, and they can severely disrupt activities of daily living.

Wikipedia:63 Ménière\'s disease /meɪnˈjɛərz/, also called endolymphatic hydrops, is a disorder of the inner ear... more...

Description from OMIM:46 156000

Aliases & Classifications for Meniere's Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 33MedlinePlus, 60UMLS, 48Orphanet, 46OMIM, 34MeSH, 27ICD9CM, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
ménière disease:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

meniere's disease 8 42 21 33
meniere disease 8 42 21 60
ménière disease 21 48 46
ménière's disease 42 21
otogenic vertigo 8 21
ménière's vertigo 21
meniere's syndrome 21
auditory vertigo 21
mnire's vertigo 8
aural vertigo 21


External Ids:

Disease Ontology8 DOID:9849
MeSH34 D008575
ICD9CM27 386.00, 386.0
OMIM46 156000
MESH via Orphanet35 D008575
ICD10 via Orphanet26 H81.0
SNOMED-CT via Orphanet57 13445001
UMLS via Orphanet61 C0025281

Related Diseases for Meniere's Disease

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Meniere's Disease:



Diseases related to meniere's disease

Clinical Features for Meniere's Disease

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46OMIM
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Clinical features from OMIM:

156000

Clinical synopsis from OMIM:

156000

Drugs & Therapeutics for Meniere's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Meniere's Disease

Drug clinical trials:

Search ClinicalTrials for Meniere's Disease

Search NIH Clinical Center for Meniere's Disease

Search CenterWatch for Meniere's Disease

Genetic Tests for Meniere's Disease

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Anatomical Context for Meniere's Disease

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32MalaCards
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MalaCards organs/tissues related to Meniere's Disease:

32
Testes, Bone, Skin

Animal Models for Meniere's Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Meniere's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.6AQP5, AQP4, AQP1, OCM2, FBXO2, COCH

Publications for Meniere's Disease

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50PubMed
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Articles related to Meniere's Disease:

(show top 50)    (show all 208)
idTitleAuthorsYear
1
Endolymphatic hydrops revealed by magnetic resonance imaging in patients with atypical Meniere's disease. (23106485)
2013
2
Tenotomy of the stapedius and tensor tympani muscles reduces subjective dizziness handicap in definite Meniere's disease. (23350595)
2013
3
The diagnostic value of vestibular evoked myogenic potentials in patients with Meniere's disease. (24284605)
2013
4
Meniere's disease: an evidence based approach to assessment and management. (22257041)
2012
5
Omega-3 fatty acids: a promising possible treatment for Meniere's disease and other inner ear disorders of unknown origin? (22800802)
2012
6
Assessment of Meniere's disease from a radiological aspect - saccular otoconia as a cause of Meniere's disease? (22998558)
2012
7
Study of cochlear hydrops analysis masking procedure in patients with Meniere's disease and otologically normal adults. (23253718)
2012
8
Blockage of longitudinal flow in Meniere's disease: A human temporal bone study. (21319945)
2011
9
Meniere's disease: new concepts, new treatments. (22413647)
2011
10
In vivo visualization of endolyphatic hydrops in patients with Meniere's disease: correlation with audiovestibular function. (21431434)
2011
11
Associations between HLA-C alleles and definite Meniere's disease. (21625020)
2011
12
Long-term effects of the Meniett device in Japanese patients with Meniere's disease and delayed endolymphatic hydrops reported by the Middle Ear Pressure Treatment Research Group of Japan. (21319947)
2011
13
A comparison of three methods of using transtympanic electrocochleography for the diagnosis of Meniere's disease: click summating potential measurements, tone burst summating potential amplitude measurements, and biasing of the summating potential using a low frequency tone. (19396716)
2010
14
Meniere's disease and the use of proton pump inhibitors. (20927682)
2010
15
Meniere's disease in the elderly. (20713243)
2010
16
Meniere's disease: 150 years and still elusive. (20713235)
2010
17
Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma. (20461409)
2010
18
Clinical hints and precipitating factors in patients suffering from Meniere's disease. (20713240)
2010
19
Does migraine-associated vertigo share a common pathophysiology with Meniere's disease? Study with vestibular-evoked myogenic potential. (19911463)
2009
20
Amplitude and area ratios of summating potential/action potential (SP/AP) in Meniere's disease. (19003588)
2009
21
Clinical long-term effects of Meniett pulse generator for Meniere's disease. (18923942)
2009
22
Understanding psychological distress in Meniere's disease: a systematic review. (18569895)
2008
23
Migraine and Meniere's disease: two different phenomena with frequently observed concomitant occurrences. (18390027)
2008
24
The results of vestibular evoked myogenic potentials, with consideration of age-related changes, in vestibular neuritis, benign paroxysmal positional vertigo, and Meniere's disease. (18607943)
2008
25
Time course of episodes of definitive vertigo in Meniere's disease. (19015442)
2008
26
In reference to 3 Tesla delayed contrast magnetic resonance imaging evaluation of Meniere's disease. (18827624)
2008
27
Vestibular evoked periocular potentials in Meniere's disease after glycerol testing. (19102124)
2008
28
Reliability of the vestibular evoked myogenic potential test in assessing intratympanic gentamicin therapy in Meniere's disease. (18368577)
2008
29
Inheritance of Meniere's disease in the Finnish population. (17224529)
2007
30
Non-specific immunological determinations in Meniere's disease: any role in clinical practice? (17033831)
2007
31
Histopathology of the vestibular end organs after intratympanic gentamicin failure for Meniere's disease. (17364327)
2007
32
Case report: Meniere's disease and otosclerosis--different outcomes of the same disease? (17118596)
2007
33
Intratympanic gentamicin in monolateral Meniere's disease: our experience. (16021460)
2006
34
Retrosigmoid approach for vestibular neurectomy in Meniere's disease. (15618995)
2005
35
Meniere's Disease and Migraine. (15897429)
2005
36
Surgical management of Meniere's disease in the era of gentamicin. (15746859)
2005
37
Allergy and Meniere's disease: a review. (17066646)
2005
38
Diagnostic test for Meniere's disease. (15891671)
2005
39
Electrocochleography in patients with Meniere's disease. (15742267)
2005
40
Treatment of Meniere's disease with the low-pressure pulse generator (Meniett device). (16293064)
2005
41
Angular vestibulo-ocular reflex gains correlate with vertigo control after intratympanic gentamicin treatment for Meniere's disease. (16285268)
2005
42
Surgical management of Meniere's disease in the era of gentamicin. (16360532)
2005
43
Postural instability in Meniere's disease. (15156095)
2004
44
Meniere's disease and allergy: allergens and cytokines. (15509365)
2004
45
Vestibular evoked myogenic potentials versus vestibular test battery in patients with Meniere's disease. (15547430)
2004
46
Intratympanic gentamicin for the treatment of Meniere's disease and other forms of peripheral vertigo. (15474112)
2004
47
Association of HLA-DR and type II collagen autoimmunity with Meniere's disease. (12622783)
2003
48
Aquaporin-2 expression in the mammalian cochlea and investigation of its role in Meniere's disease. (12208541)
2002
49
Meniere's disease and endolymphatic hydrops without Meniere's symptoms: temporal bone histopathology. (10380731)
1999
50
Meniere's disease: evidence of an immune process. (9752971)
1998

Genetic Variations for Meniere's Disease

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Expression for genes affiliated with Meniere's Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meniere's Disease

Search GEO for disease gene expression data for Meniere's Disease.

Pathways for genes affiliated with Meniere's Disease

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53Reactome, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Meniere's Disease

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Meniere's Disease according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1hg2+4410.6MIP, AQP1
2pcmbs4410.5MIP, AQP1
3delta-12-pgj24410.5HSPA8, HSPA4
4hgcl24410.5AQP2, AQP1, MIP
5geranylgeranylacetone4410.5HSPA8, HSPA4
6ba2+2810.4KCNJ4, KCNJ14
7cs+2810.4KCNJ4, KCNJ14
8cyclopentenone4410.4HSPA8, HSPA4
9tetraethylammonium44 28 1112.4KCNJ4, MIP, AQP1
10p10755910.4KCNJ9, KCNJ4, KCNJ14
11levcromakalim5910.4KCNJ9, KCNJ4, KCNJ14
12bicarbonate4410.4AQP4, AQP1, MIP
13tertiapin-q5910.4KCNJ9, KCNJ4, KCNJ14
14h+ (extracellular)2810.4KCNJ14, KCNJ4
15vas-a4410.3AQP4, AQP1
16diazoxide44 59 28 1113.3KCNJ9, KCNJ4, KCNJ14
17silver4410.3HSPA8, HSPA4, MIP, AQP1
18cdcl24410.3HSPA4, HSPA8
19chloride4410.3MIP, AQP1, AQP2, AQP4
20glibenclamide44 28 49 5913.3KCNJ14, KCNJ4, KCNJ9
21urea44 11 2412.3HSPA8, MIP, AQP1, AQP2, AQP4
22prostaglandin4410.2AQP2, PTGFR, HSPA4, HSPA8
23mannitol44 1111.2AQP4, AQP1, MIP, HSPA4, HSPA8
24mercury4410.2HSPA4, MIP, AQP1, AQP2, AQP4
25methionine4410.2HSPA8, HSPA4, AQP1, AQP2
26mg2+2810.2KCNJ14, KCNJ4
27hydrogen44 2411.2AQP2, AQP1, MIP, HSPA4, HSPA8
28hg2+2810.1AQP7, MIP, AQP6, AQP1, AQP2, AQP5
29sodium44 2411.1HSPA8, HSPA4, MIP, AQP1, AQP2, AQP4
30cysteine4410.0COCH, HSPA8, MIP, AQP1, AQP2, AQP4
31sodium nitroprusside4410.0AQP1, HSPA4, HSPA8
32magnesium44 11 2411.9AQP2, OCM2, KCNJ14, KCNJ4, KCNJ9
33forskolin44 49 1111.9AQP7, AQP2, AQP1, PTGFR
34steroid449.7HSPA8, HSPA4, PTGFR, AQP1, AQP2
35glycerol44 11 2411.7HSPA8, HSPA4, MIP, AQP6, AQP1, AQP2
36potassium44 11 2411.6HSPA8, HSPA4, KCNJ9, KCNJ4, KCNE3, MIP
37dexamethasone44 49 28 1112.5HSPA4, MIP, AQP1, AQP2, AQP4

GO Terms for genes affiliated with Meniere's Disease

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16Gene Ontology
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Cellular components related to Meniere's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.8AQP4, AQP2, AQP1, KCNJ4
2integral to plasma membraneGO:0058879.2MIP, PTGFR, AQP6, AQP1, AQP4, AQP5
3plasma membraneGO:0058868.9KCNJ9, KCNJ4, KCNJ14, MIP, PTGFR, AQP1

Biological processes related to Meniere's Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1renal water transportGO:00309710.4AQP2, AQP1
2multicellular organismal water homeostasisGO:05089110.3AQP4, AQP1
3glycerol transportGO:01579310.3AQP1, AQP2, AQP7
4cellular response to mercury ionGO:07128810.3AQP2, AQP1
5carbon dioxide transportGO:01567010.3AQP1, AQP4, AQP5
6renal water absorptionGO:07029510.3AQP4, AQP7
7odontogenesisGO:04247610.2AQP6, AQP1, AQP5
8pancreatic juice secretionGO:03015710.2AQP5, AQP1
9cellular response to copper ionGO:07128010.1AQP2, AQP1
10excretionGO:00758810.1AQP6, AQP2, AQP4, AQP5, AQP7
11cell volume homeostasisGO:0068849.9AQP1, AQP2
12synaptic transmissionGO:0072689.9KCNJ14, KCNJ4, KCNJ9, HSPA8
13water transportGO:0068339.8AQP7, AQP5, AQP4, AQP2, AQP1, AQP6
14transmembrane transportGO:0550859.8MIP, AQP6, AQP1, AQP2, AQP4, AQP5

Molecular functions related to Meniere's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inward rectifier potassium channel activityGO:00524210.1KCNJ14, KCNJ4
2water transmembrane transporter activityGO:00537210.0AQP1, AQP2, AQP4
3glycerol transmembrane transporter activityGO:0151689.9AQP2, AQP1
4water channel activityGO:0152509.8AQP7, AQP5, AQP1, AQP6, MIP

Products for genes affiliated with Meniere's Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Meniere's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet