MCID: MNR002
MIFTS: 38

Meniere's Disease malady

Summaries for Meniere's Disease

Sources:
43NIH Rare Diseases, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Ménière's disease is an abnormality of the inner ear. signs and symptoms may include disabling vertigo or severe dizziness lasting from minutes to hours; tinnitus or a roaring sound in the ears; fluctuating hearing loss; and the sensation of pressure or pain in the affected ear. a small percentage people have drop attacks, also called spells of tumarkin. the disorder usually affects only one ear and is a common cause of hearing loss. some people develop symptoms in both ears many years after their initial diagnosis. the exact cause of ménière's disease is unknown, but the symptoms are thought to be associated with a change in fluid volume within a portion of the inner ear known as the labyrinth. treatment may include medications or surgery depending on the severity of the condition. last updated: 3/12/2013

MalaCards: Meniere's Disease, also known as meniere disease, is related to menieres disease and m�ni�re disease. An important gene associated with Meniere's Disease is MIP (major intrinsic protein of lens fiber), and among its related pathways are Classical Kir channels and Regulation of Water Balance by Renal Aquaporins. The compounds hg2+ and pcmbs have been mentioned in the context of this disorder. Related mouse phenotype hearing/vestibular/ear.

Description from OMIM:47 156000

Aliases & Classifications for Meniere's Disease

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT, 47OMIM
See all sources

Aliases & Descriptions:

meniere's disease 8 43
meniere disease 8 43 61
ménière's disease 43
otogenic vertigo 8
mnire's vertigo 8


External Ids:

Disease Ontology8 DOID:9849
MeSH35 D008575
ICD9CM27 386.00, 386.0
OMIM47 156000

Related Diseases for Meniere's Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of diseases related to Meniere's Disease:



Diseases related to meniere's disease

Clinical Features for Meniere's Disease

Sources:
47OMIM
See all sources

Clinical features from OMIM:

156000

Drugs & Therapeutics for Meniere's Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Meniere's Disease

Drug clinical trials:

Search ClinicalTrials for Meniere's Disease

Search NIH Clinical Center for Meniere's Disease

Search CenterWatch for Meniere's Disease

Genetic Tests for Meniere's Disease

Anatomical Context for Meniere's Disease

Animal Models for Meniere's Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Meniere's Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.6AQP5, AQP4, AQP1, OCM2, FBXO2, COCH

Publications for Meniere's Disease

Sources:
51PubMed
See all sources

Articles related to Meniere's Disease:

(show top 50)    (show all 72)
idTitleAuthorsYear
1
Motion sensitivity and caloric responsiveness in vestibular migraine and Meniere's disease. (23818082)
2013
2
Tenotomy of the stapedius and tensor tympani muscles reduces subjective dizziness handicap in definite Meniere's disease. (23350595)
2013
3
Results of caloric and sensory organization testing of dynamic posturography in migrainous vertigo: comparison with Meniere's disease and vestibular neuritis. (23947606)
2013
4
Enhanced vestibulo-ocular reflex to electrical vestibular stimulation in Meniere's disease. (23239162)
2013
5
Long-term results of endolymphatic sac drainage with local steroids for intractable Meniere's disease. (23273764)
2013
6
Vestibular evoked myogenic potentials to sound and vibration: characteristics in vestibular migraine that enable separation from Meniere's disease. (22259049)
2012
7
Comparison of noninvasive evaluation of endolymphatic hydrops in Meniere's disease and endolymphatic space in healthy volunteers using magnetic resonance imaging. (22201445)
2012
8
Hearing results and quality of life after streptomycin/dexamethasone perfusion for Meniere's disease. (22183636)
2012
9
Lateral semicircular canal plugging with endolymphatic sac decompression as new surgical treatment for intractable Meniere's disease. (22404302)
2012
10
Assessment of Meniere's disease from a radiological aspect - saccular otoconia as a cause of Meniere's disease? (22998558)
2012
11
Imaging of endolymphatic hydrops in Meniere's disease at 1.5 T using phase-sensitive inversion recovery: (1) demonstration of feasibility and (2) overcoming the limitations of variable gadolinium absorption. (21330087)
2012
12
Study of cochlear hydrops analysis masking procedure in patients with Meniere's disease and otologically normal adults. (23253718)
2012
13
Furosemide-loading vestibular evoked myogenic potential testing can suggest developing bilateral involvement of unilateral Meniere's disease. (22497197)
2012
14
Endolymphatic hydrops in Meniere's disease detected by MRI after intratympanic administration of gadolinium: comparison with sudden deafness. (21344957)
2011
15
Blockage of longitudinal flow in Meniere's disease: A human temporal bone study. (21319945)
2011
16
Similarity of vertigo attacks due to Meniere's disease and benign recurrent vertigo, both with and without migraine. (21469911)
2011
17
A comparison of three methods of using transtympanic electrocochleography for the diagnosis of Meniere's disease: click summating potential measurements, tone burst summating potential amplitude measurements, and biasing of the summating potential using a low frequency tone. (19396716)
2010
18
A case of Meniere's disease in the left ear and Lermoyez syndrome in the right ear--a 32-month longitudinal observation and literature review. (20148752)
2010
19
A novel model for prognosis of Meniere's disease using oxidative stress susceptibility of lymphoblastoid cell lines. (20448344)
2010
20
Comment: Subjective visual vertical in acute attacks of Meniere's disease. (19638935)
2010
21
Physiologic effects on the vestibular system in Meniere's disease. (20713238)
2010
22
Changes in the characteristics of definite Meniere's disease over time in Japan: a long-term survey by the Peripheral Vestibular Disorder Research Committee of Japan, formerly the Meniere's Disease Research Committee of Japan. (18607900)
2009
23
Amplitude and area ratios of summating potential/action potential (SP/AP) in Meniere's disease. (19003588)
2009
24
Oculomotor findings mimicking a cerebellar disorder and postural control in severe Meniere's disease. (18501541)
2009
25
Clinical significance of the summating potential-action potential ratio and the action potential latency difference for condensation and rarefaction clicks in Meniere's disease. (19462853)
2009
26
Improved sensitivity of electrocochleography in the diagnosis of Meniere's disease. (19951149)
2009
27
Short-term hearing fluctuation in Meniere's disease. (19842814)
2009
28
Poly(ADP-ribose) polymerase-1 (PARP-1) longer alleles spanning the promoter region may confer protection to bilateral Meniere's disease. (19863315)
2009
29
Study of vestibular evoked myogenic potentials in patients affected by Meniere's disease treated with endolymphatic mastoid shunt. (20112519)
2009
30
Vestibular type of Mondini anomalies with BPPV and Meniere's disease-like symptoms. (18614306)
2009
31
Non-specific immunological determinations in Meniere's disease: any role in clinical practice? (17033831)
2007
32
Sympathetic skin responses from postauricular region in Meniere's disease. (17604692)
2007
33
Effects of a single intratympanic gentamicin injection on Meniere's disease. (17882572)
2007
34
Meniere's disease may be caused by common intraosseous dental pathology--Diagnosis using the comparative compression sign. (16962722)
2007
35
Low dose transtympanic gentamicin treatment for intractable Meniere's disease: a prospective study. (17375639)
2007
36
Evolution of audiometric pattern in Meniere's disease: long-term survey of 380 cases evaluated according to the 1995 guidelines of the American Academy of Otolaryngology-Head and Neck Surgery. (16527013)
2006
37
Disorder of the saliva melatonin circadian rhythm in patients with Meniere's disease. (16542165)
2006
38
Meniere's disease or migraine? The clinical significance of fluctuating hearing loss with vertigo. (15897428)
2005
39
Surgical management of Meniere's disease in the era of gentamicin. (15746859)
2005
40
Trends in the diagnosis and the management of Meniere's disease: results of a survey. (15886625)
2005
41
Surgical treatment of Meniere's disease. (15655398)
2005
42
The basic science of Meniere's disease and endolymphatic hydrops. (16160525)
2005
43
Local overpressure treatment reduces vestibular symptoms in patients with Meniere's disease: a clinical, randomized, multicenter, double-blind, placebo-controlled study. (15699722)
2005
44
Intratympanic dexamethasone application in Meniere's disease-Is it superior to conventional therapy? (23120117)
2005
45
Surgical management of Meniere's disease in the era of gentamicin. (16360532)
2005
46
Surgical management of special cases of intractable Meniere's disease: unilateral cases with intact canals and bilateral cases. (15174769)
2004
47
Perilymphatic fistula and Meniere's disease. Clinical series and literature review. (11372926)
2001
48
Anti-heat shock protein 70 antibodies in Meniere's disease. (11224793)
2001
49
Meniere's disease and endolymphatic hydrops without Meniere's symptoms: temporal bone histopathology. (10380731)
1999
50
Comparison of anti-heat shock protein 70 (anti-hsp70) and anti-68-kDa inner ear protein in the sera of patients with Meniere's disease. (9023247)
1997

Genetic Variations for Meniere's Disease

Expression for genes affiliated with Meniere's Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Meniere's Disease

Search GEO for disease gene expression data for Meniere's Disease.

Pathways for genes affiliated with Meniere's Disease

Sources:
54Reactome, 12EMD Millipore, 52QIAGEN
See all sources

Compounds for genes affiliated with Meniere's Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to Meniere's Disease according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1hg2+4510.6MIP, AQP1
2pcmbs4510.5MIP, AQP1
3delta-12-pgj24510.5HSPA8, HSPA4
4hgcl24510.5AQP2, AQP1, MIP
5geranylgeranylacetone4510.5HSPA8, HSPA4
6ba2+2910.4KCNJ4, KCNJ14
7cs+2910.4KCNJ4, KCNJ14
8tetraethylammonium45 29 1112.4KCNJ4, MIP, AQP1
9cyclopentenone4510.4HSPA8, HSPA4
10p10756010.4KCNJ9, KCNJ4, KCNJ14
11bicarbonate4510.4AQP4, AQP1, MIP
12levcromakalim6010.4KCNJ9, KCNJ4, KCNJ14
13tertiapin-q6010.4KCNJ9, KCNJ4, KCNJ14
14h+ (extracellular)2910.4KCNJ14, KCNJ4
15vas-a4510.3AQP4, AQP1
16diazoxide45 60 29 1113.3KCNJ9, KCNJ4, KCNJ14
17silver4510.3HSPA8, HSPA4, MIP, AQP1
18cdcl24510.3HSPA4, HSPA8
19chloride4510.3MIP, AQP1, AQP2, AQP4
20glibenclamide45 29 50 6013.3KCNJ14, KCNJ4, KCNJ9
21urea45 11 2412.3HSPA8, MIP, AQP1, AQP2, AQP4
22prostaglandin4510.2AQP2, PTGFR, HSPA4, HSPA8
23mannitol45 1111.2AQP4, AQP1, MIP, HSPA4, HSPA8
24mercury4510.2HSPA4, MIP, AQP1, AQP2, AQP4
25methionine4510.2HSPA8, HSPA4, AQP1, AQP2
26mg2+2910.2KCNJ14, KCNJ4
27hydrogen45 2411.2AQP2, AQP1, MIP, HSPA4, HSPA8
28hg2+2910.1AQP7, MIP, AQP6, AQP1, AQP2, AQP5
29sodium45 2411.1HSPA8, HSPA4, MIP, AQP1, AQP2, AQP4
30cysteine4510.0COCH, HSPA8, MIP, AQP1, AQP2, AQP4
31sodium nitroprusside4510.0AQP1, HSPA4, HSPA8
32magnesium45 11 2411.9AQP2, OCM2, KCNJ14, KCNJ4, KCNJ9
33forskolin45 50 1111.9AQP7, AQP2, AQP1, PTGFR
34steroid459.7HSPA8, HSPA4, PTGFR, AQP1, AQP2
35glycerol45 11 2411.7HSPA8, HSPA4, MIP, AQP6, AQP1, AQP2
36potassium45 11 2411.6HSPA8, HSPA4, KCNJ9, KCNJ4, KCNE3, MIP
37dexamethasone45 50 29 1112.5HSPA4, MIP, AQP1, AQP2, AQP4

GO Terms for genes affiliated with Meniere's Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Meniere's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.8KCNJ4, AQP1, AQP2, AQP4
2integral to plasma membraneGO:0058879.2AQP5, AQP4, AQP1, AQP6, PTGFR, MIP
3plasma membraneGO:0058868.9HSPA8, AQP5, AQP4, AQP2, AQP1, PTGFR

Biological processes related to Meniere's Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1renal water transportGO:00309710.4AQP2, AQP1
2cellular response to mercury ionGO:07128810.4AQP2, AQP1
3carbon dioxide transportGO:01567010.3AQP5, AQP4, AQP1
4glycerol transportGO:01579310.3AQP1, AQP2, AQP7
5multicellular organismal water homeostasisGO:05089110.3AQP4, AQP1
6renal water absorptionGO:07029510.3AQP4, AQP7
7odontogenesisGO:04247610.2AQP5, AQP1, AQP6
8pancreatic juice secretionGO:03015710.2AQP1, AQP5
9cellular response to copper ionGO:07128010.1AQP1, AQP2
10excretionGO:00758810.1AQP7, AQP5, AQP4, AQP2, AQP6
11cell volume homeostasisGO:0068849.9AQP1, AQP2
12synaptic transmissionGO:0072689.9KCNJ14, HSPA8, KCNJ9, KCNJ4
13water transportGO:0068339.8AQP2, MIP, AQP6, AQP1, AQP4, AQP5
14transmembrane transportGO:0550859.8AQP7, AQP5, AQP2, AQP1, AQP6, MIP

Molecular functions related to Meniere's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inward rectifier potassium channel activityGO:00524210.1KCNJ14, KCNJ4
2water transmembrane transporter activityGO:00537210.0AQP1, AQP2, AQP4
3glycerol transmembrane transporter activityGO:0151689.9AQP2, AQP1
4water channel activityGO:0152509.8AQP7, AQP5, AQP1, AQP6, MIP

Products for genes affiliated with Meniere's Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Meniere's Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet