MCID: MNR002
MIFTS: 52

Meniere's Disease malady

Summaries for Meniere's Disease

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42NIH Rare Diseases, 33MedlinePlus, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Meniere's disease is a disorder of the inner ear. it can cause severe dizziness, a roaring sound in your ears called tinnitus, hearing loss that comes and goes and the feeling of ear pressure or pain. it usually affects just one ear. it is a common cause of hearing loss. attacks of dizziness may come on suddenly or after a short period of tinnitus or muffled hearing. some people have single attacks of dizziness once in a while. others may have many attacks close together over several days. some people with meniere's disease have "drop attacks" during which the dizziness is so bad they lose their balance and fall. scientists don't yet know the cause. they think that it has to do with the fluid levels or the mixing of fluids in the canals of your inner ear. doctors diagnose it based on a physical exam and your symptoms. a hearing test can check to see how it has affected your hearing. there is no cure. treatments include medicines to control dizziness, limiting salt in your diet, and taking water pills. a device that fits into the outer ear and delivers air pulses to the middle ear can help. severe cases may require surgery. nih: national institute on deafness and other communication disorders

MalaCards: Meniere's Disease, also known as meniere disease, is related to menieres disease and hypoparathyroidism. An important gene associated with Meniere's Disease is COCH (cochlin), and among its related pathways are Classical Kir channels and Regulation of Water Balance by Renal Aquaporins. The compounds hg2+ and pcmbs have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and skin, and related mouse phenotype hearing/vestibular/ear.

NIH Rare Diseases:42 Ménière's disease is an abnormality of the inner ear. signs and symptoms may include disabling vertigo or severe dizziness lasting from minutes to hours; tinnitus or a roaring sound in the ears; fluctuating hearing loss; and the sensation of pressure or pain in the affected ear. a small percentage people have drop attacks, also called spells of tumarkin. the disorder usually affects only one ear and is a common cause of hearing loss. some people develop symptoms in both ears many years after their initial diagnosis. the exact cause of ménière's disease is unknown, but the symptoms are thought to be associated with a change in fluid volume within a portion of the inner ear known as the labyrinth. treatment may include medications or surgery depending on the severity of the condition. last updated: 3/12/2013

Genetics Home Reference:21 Ménière disease is a disorder of the inner ear that affects balance and hearing. This condition is characterized by sudden episodes of extreme dizziness (vertigo), a roaring sound in the ears (tinnitus), a feeling of pressure or fullness in the ears, and fluctuations in hearing. Episodes are often associated with nausea and vomiting, and they can severely disrupt activities of daily living.

Wikipedia:63 Ménière\'s disease /meɪnˈjɛərz/, also called endolymphatic hydrops, is a disorder of the inner ear... more...

Description from OMIM:46 156000

Aliases & Classifications for Meniere's Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 33MedlinePlus, 60UMLS, 48Orphanet, 46OMIM, 34MeSH, 27ICD9CM, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
ménière disease:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

meniere's disease 8 42 21 33
meniere disease 8 42 21 60
ménière disease 21 48 46
ménière's disease 42 21
otogenic vertigo 8 21
ménière's vertigo 21
meniere's syndrome 21
auditory vertigo 21
mnire's vertigo 8
aural vertigo 21


External Ids:

Disease Ontology8 DOID:9849
MeSH34 D008575
ICD9CM27 386.00, 386.0
OMIM46 156000
MESH via Orphanet35 D008575
ICD10 via Orphanet26 H81.0
SNOMED-CT via Orphanet57 13445001
UMLS via Orphanet61 C0025281

Related Diseases for Meniere's Disease

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Meniere's Disease:



Diseases related to meniere's disease

Clinical Features for Meniere's Disease

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Sources:
46OMIM
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Clinical features from OMIM:

156000

Clinical synopsis from OMIM:

156000

Drugs & Therapeutics for Meniere's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Meniere's Disease

Drug clinical trials:

Search ClinicalTrials for Meniere's Disease

Search NIH Clinical Center for Meniere's Disease

Search CenterWatch for Meniere's Disease

Genetic Tests for Meniere's Disease

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Anatomical Context for Meniere's Disease

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32MalaCards
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MalaCards organs/tissues related to Meniere's Disease:

32
Testes, Bone, Skin

Animal Models for Meniere's Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Meniere's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.6AQP5, AQP4, AQP1, OCM2, FBXO2, COCH

Publications for Meniere's Disease

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Sources:
50PubMed
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Articles related to Meniere's Disease:

(show top 50)    (show all 208)
idTitleAuthorsYear
1
Familial clustering and genetic heterogeneity in Meniere's disease. (23521103)
2013
2
Two-dimensional analysis of head-shaking nystagmus in patients with Meniere's disease. (23788137)
2013
3
Potential application of ocular and cervical vestibular-evoked myogenic potentials in Meniere's disease: a review. (23070719)
2013
4
Enhanced vestibulo-ocular reflex to electrical vestibular stimulation in Meniere's disease. (23239162)
2013
5
Visualization of endolymphatic hydrops and correlation with audio-vestibular functional testing in patients with definite Meniere's disease. (22867525)
2013
6
Comparison of noninvasive evaluation of endolymphatic hydrops in Meniere's disease and endolymphatic space in healthy volunteers using magnetic resonance imaging. (22201445)
2012
7
Lateral semicircular canal plugging with endolymphatic sac decompression as new surgical treatment for intractable Meniere's disease. (22404302)
2012
8
Imaging of endolymphatic hydrops in Meniere's disease at 1.5 T using phase-sensitive inversion recovery: (1) demonstration of feasibility and (2) overcoming the limitations of variable gadolinium absorption. (21330087)
2012
9
Inadequate opening capacity of the eustachian tube in Meniere's disease. (22201512)
2012
10
Longitudinal study of 29 patients with Meniere's disease with follow-up of 10 years or more (In commemoration of Professor Emeritus Isamu Watanabe). (22054051)
2012
11
Benign paroxysmal positional vertigo associated with Meniere's disease: epidemiological, pathophysiologic, clinical, and therapeutic aspects. (23130545)
2012
12
Endolymphatic hydrops in Meniere's disease detected by MRI after intratympanic administration of gadolinium: comparison with sudden deafness. (21344957)
2011
13
Meniere's disease: Still a mystery disease with difficult differential diagnosis. (21633608)
2011
14
Eustachian tube function in patients with Meniere's disease. (21036498)
2011
15
Vasopressin in definite Meniere's disease with positive electrocochleographic findings. (21271947)
2011
16
About plasma arginin vasopressin levels and Meniere's disease. (21077807)
2011
17
Changes in endolymphatic hydrops in a patient with Meniere's disease observed using magnetic resonance imaging. (19540682)
2010
18
Analysis of hearing preservation after endolymphatic mastoid sac surgery for Meniere's disease. (20131368)
2010
19
Comment: Subjective visual vertical in acute attacks of Meniere's disease. (19638935)
2010
20
Allergy and its relation to Meniere's disease. (20713244)
2010
21
Audiovestibular testing in patients with Meniere's disease. (20713239)
2010
22
Impact of bilaterality and headache on health-related quality of life in Meniere's disease. (19663372)
2009
23
Utility of immunologic parameters in the evaluation of Meniere's disease. (19863304)
2009
24
Oculomotor findings mimicking a cerebellar disorder and postural control in severe Meniere's disease. (18501541)
2009
25
Clinical significance of the summating potential-action potential ratio and the action potential latency difference for condensation and rarefaction clicks in Meniere's disease. (19462853)
2009
26
Short-term hearing fluctuation in Meniere's disease. (19842814)
2009
27
A comparison of two methods of using transtympanic electrocochleography for the diagnosis of Meniere's disease: click summating potential/action potential ratio measurements and tone burst summating potential measurements. (19221905)
2009
28
Endolymphatic hydrops and therapeutic effects are visualized in 'atypical' Meniere's disease. (19863332)
2009
29
EVestG: a measure for Meniere's Disease. (19163629)
2008
30
Periodic alternating nystagmus in Meniere's disease: the peripheral type? (18568528)
2008
31
Effects of endolymphatic sac drainage with steroids for intractable Meniere's disease: a long-term follow-up and randomized controlled study. (18520184)
2008
32
Epley's maneuver in benign paroxysmal positional vertigo associated with Meniere's disease. (17923921)
2007
33
Visualization of endolymphatic hydrops in patients with Meniere's disease. (17279053)
2007
34
Meniere's disease may be caused by common intraosseous dental pathology--Diagnosis using the comparative compression sign. (16962722)
2007
35
Intratympanic gentamicin: a 1-day protocol treatment for unilateral Meniere's disease. (17826528)
2007
36
Vestibular evoked myogenic potentials in benign paroxysmal positional vertigo and Meniere's disease. (16482459)
2006
37
Disorder of the saliva melatonin circadian rhythm in patients with Meniere's disease. (16542165)
2006
38
Transtympanic gentamicin treatment in Meniere's disease: a preliminary report. (16881430)
2006
39
Endolymphatic sac decompression as a treatment for Meniere's disease. (16094123)
2005
40
Meniere's disease or migraine? The clinical significance of fluctuating hearing loss with vertigo. (15897428)
2005
41
The association of antidiuretic hormone levels with an attack of Meniere's disease. (16402977)
2005
42
The basic science of Meniere's disease and endolymphatic hydrops. (16160525)
2005
43
Comparative study of the daily lifestyle of patients with Meniere's disease and controls. (16425558)
2005
44
Meniere's disease. (15865674)
2004
45
The effects of transtympanic micropressure treatment in people with unilateral Meniere's disease. (15210552)
2004
46
Mutations in the COCH gene are a frequent cause of autosomal dominant progressive cochleo-vestibular dysfunction, but not of Meniere's disease. (14512963)
2003
47
Anti-heat shock protein 70 antibodies in Meniere's disease. (11224793)
2001
48
High prevalence of symptoms of Meniere's disease in three families with a mutation in the COCH gene. (10400989)
1999
49
Temporal bone histopathology: residents' quiz. Endolymphatic hydrops (Meniere's disease). (1858976)
1991
50
Hyperlipoproteinemia, hyperinsulinism, and Meniere's disease. (7292056)
1981

Genetic Variations for Meniere's Disease

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Expression for genes affiliated with Meniere's Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meniere's Disease

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Pathways for genes affiliated with Meniere's Disease

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53Reactome, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Meniere's Disease

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Meniere's Disease according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1hg2+4410.6MIP, AQP1
2pcmbs4410.5MIP, AQP1
3delta-12-pgj24410.5HSPA8, HSPA4
4hgcl24410.5AQP2, AQP1, MIP
5geranylgeranylacetone4410.5HSPA8, HSPA4
6ba2+2810.4KCNJ4, KCNJ14
7cs+2810.4KCNJ4, KCNJ14
8cyclopentenone4410.4HSPA8, HSPA4
9tetraethylammonium44 28 1112.4KCNJ4, MIP, AQP1
10p10755910.4KCNJ9, KCNJ4, KCNJ14
11levcromakalim5910.4KCNJ9, KCNJ4, KCNJ14
12bicarbonate4410.4AQP4, AQP1, MIP
13tertiapin-q5910.4KCNJ9, KCNJ4, KCNJ14
14h+ (extracellular)2810.4KCNJ14, KCNJ4
15vas-a4410.3AQP4, AQP1
16diazoxide44 59 28 1113.3KCNJ9, KCNJ4, KCNJ14
17silver4410.3HSPA8, HSPA4, MIP, AQP1
18cdcl24410.3HSPA4, HSPA8
19chloride4410.3MIP, AQP1, AQP2, AQP4
20glibenclamide44 28 49 5913.3KCNJ14, KCNJ4, KCNJ9
21urea44 11 2412.3HSPA8, MIP, AQP1, AQP2, AQP4
22prostaglandin4410.2AQP2, PTGFR, HSPA4, HSPA8
23mannitol44 1111.2AQP4, AQP1, MIP, HSPA4, HSPA8
24mercury4410.2HSPA4, MIP, AQP1, AQP2, AQP4
25methionine4410.2HSPA8, HSPA4, AQP1, AQP2
26mg2+2810.2KCNJ14, KCNJ4
27hydrogen44 2411.2AQP2, AQP1, MIP, HSPA4, HSPA8
28hg2+2810.1AQP7, MIP, AQP6, AQP1, AQP2, AQP5
29sodium44 2411.1HSPA8, HSPA4, MIP, AQP1, AQP2, AQP4
30cysteine4410.0COCH, HSPA8, MIP, AQP1, AQP2, AQP4
31sodium nitroprusside4410.0AQP1, HSPA4, HSPA8
32magnesium44 11 2411.9AQP2, OCM2, KCNJ14, KCNJ4, KCNJ9
33forskolin44 49 1111.9AQP7, AQP2, AQP1, PTGFR
34steroid449.7HSPA8, HSPA4, PTGFR, AQP1, AQP2
35glycerol44 11 2411.7HSPA8, HSPA4, MIP, AQP6, AQP1, AQP2
36potassium44 11 2411.6HSPA8, HSPA4, KCNJ9, KCNJ4, KCNE3, MIP
37dexamethasone44 49 28 1112.5HSPA4, MIP, AQP1, AQP2, AQP4

GO Terms for genes affiliated with Meniere's Disease

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16Gene Ontology
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Cellular components related to Meniere's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.8AQP4, AQP2, AQP1, KCNJ4
2integral to plasma membraneGO:0058879.2MIP, PTGFR, AQP6, AQP1, AQP4, AQP5
3plasma membraneGO:0058868.9KCNJ9, KCNJ4, KCNJ14, MIP, PTGFR, AQP1

Biological processes related to Meniere's Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1renal water transportGO:00309710.4AQP2, AQP1
2multicellular organismal water homeostasisGO:05089110.3AQP4, AQP1
3glycerol transportGO:01579310.3AQP1, AQP2, AQP7
4cellular response to mercury ionGO:07128810.3AQP2, AQP1
5carbon dioxide transportGO:01567010.3AQP1, AQP4, AQP5
6renal water absorptionGO:07029510.3AQP4, AQP7
7odontogenesisGO:04247610.2AQP6, AQP1, AQP5
8pancreatic juice secretionGO:03015710.2AQP5, AQP1
9cellular response to copper ionGO:07128010.1AQP2, AQP1
10excretionGO:00758810.1AQP6, AQP2, AQP4, AQP5, AQP7
11cell volume homeostasisGO:0068849.9AQP1, AQP2
12synaptic transmissionGO:0072689.9KCNJ14, KCNJ4, KCNJ9, HSPA8
13water transportGO:0068339.8AQP7, AQP5, AQP4, AQP2, AQP1, AQP6
14transmembrane transportGO:0550859.8MIP, AQP6, AQP1, AQP2, AQP4, AQP5

Molecular functions related to Meniere's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inward rectifier potassium channel activityGO:00524210.1KCNJ14, KCNJ4
2water transmembrane transporter activityGO:00537210.0AQP1, AQP2, AQP4
3glycerol transmembrane transporter activityGO:0151689.9AQP2, AQP1
4water channel activityGO:0152509.8AQP7, AQP5, AQP1, AQP6, MIP

Products for genes affiliated with Meniere's Disease

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  • Antibodies
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Sources for Meniere's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet