MCID: MNR002
MIFTS: 63

Meniere's Disease malady

Rare diseases, Ear diseases categories
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Summaries for Meniere's Disease

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MedlinePlus:33 Meniere's disease is a disorder of the inner ear. it can cause severe dizziness, a roaring sound in your ears called tinnitus, hearing loss that comes and goes and the feeling of ear pressure or pain. it usually affects just one ear. it is a common cause of hearing loss. attacks of dizziness may come on suddenly or after a short period of tinnitus or muffled hearing. some people have single attacks of dizziness once in a while. others may have many attacks close together over several days. some people with meniere's disease have "drop attacks" during which the dizziness is so bad they lose their balance and fall. scientists don't yet know the cause. they think that it has to do with the fluid levels or the mixing of fluids in the canals of your inner ear. doctors diagnose it based on a physical exam and your symptoms. a hearing test can check to see how it has affected your hearing. there is no cure. treatments include medicines to control dizziness, limiting salt in your diet, and taking water pills. a device that fits into the outer ear and delivers air pulses to the middle ear can help. severe cases may require surgery. nih: national institute on deafness and other communication disorders

MalaCards based summary: Meniere's Disease, also known as meniere disease, is related to diabetes insipidus and acute disseminated encephalomyelitis, and has symptoms including An important gene associated with Meniere's Disease is COCH (cochlin), and among its related pathways are OX40 Pathway and CD28 co-stimulation. The compounds hg2+ and hgcl2 have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and skin, and related mouse phenotypes are hearing/vestibular/ear and respiratory system.

Disease Ontology:8 A vestibular disease characterized by vertigo, characterized by low-pitched tinnitus and characterized by hearing loss.

NIH Rare Diseases:42 Ménière's disease is an abnormality of the inner ear. signs and symptoms may include disabling vertigo or severe dizziness lasting from minutes to hours; tinnitus or a roaring sound in the ears; fluctuating hearing loss; and the sensation of pressure or pain in the affected ear. a small percentage people have drop attacks, also called spells of tumarkin. the disorder usually affects only one ear and is a common cause of hearing loss. some people develop symptoms in both ears many years after their initial diagnosis. the exact cause of ménière's disease is unknown, but the symptoms are thought to be associated with a change in fluid volume within a portion of the inner ear known as the labyrinth. treatment may include medications or surgery depending on the severity of the condition. last updated: 3/12/2013

Genetics Home Reference:21 Ménière disease is a disorder of the inner ear that affects balance and hearing. This condition is characterized by sudden episodes of extreme dizziness (vertigo), a roaring sound in the ears (tinnitus), a feeling of pressure or fullness in the ears, and fluctuations in hearing. Episodes are often associated with nausea and vomiting, and they can severely disrupt activities of daily living.

Wikipedia:65 M more...

Description from OMIM:46 156000

Aliases & Classifications for Meniere's Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Meniere's Disease, Aliases & Descriptions:

Name: Meniere's Disease 8 42 21 33
Meniere Disease 8 42 21 62
Ménière Disease 21 48 46
Otogenic Vertigo 8 21 62
Ménière's Disease 42 21
Meniere's Syndrome 21 62
 
Auditory Vertigo 21 62
Menieres Disease 10 44
Ménière's Vertigo 21
Mnire's Vertigo 8
Vertigo, Aural 62
Aural Vertigo 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Ear diseases


Characteristics (Orphanet epidemiological data):

48
ménière disease:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


External Ids:

Disease Ontology8 DOID:9849
OMIM46 156000
MeSH34 D008575
ICD9CM27 386.0, 386.00
MESH via Orphanet35 D008575
ICD10 via Orphanet26 H81.0
UMLS via Orphanet63 C0025281

Related Diseases for Meniere's Disease

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Diseases related to Meniere's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus10.5AQP2, AQP6
2acute disseminated encephalomyelitis10.5AQP4
3diabetic ketoacidosis10.5CTLA4
4leprosy10.4HLA-DRB1
5vogt-koyanagi-harada disease10.4HLA-DRB1
6idiopathic edema10.4AQP1, AQP2
7endolymphatic hydrops10.4AQP7, AQP2, MIP
8nephrogenic diabetes insipidus10.4AQP2, AQP1, MIP
9brain edema10.4AQP4, AQP1, MIP
10auditory system disease10.3HSPA8, HSPA4
11aspergillosis10.3IFNG
12hepatic encephalopathy10.3AQP4, CSN1S1
13periapical granuloma10.3IL4
14rheumatoid arthritis10.3PTPN22, HLA-DRB1
15oral lichen planus10.3HSPA8, HSPA4
16stroke, ischemic10.2HSPA8, HSPA4, AQP4
17celiac disease10.2CTLA4, CSN1S1, PTPN22
18liver cirrhosis10.2HLA-DRB1, AQP2, MIP
19pneumonia10.2MIP, HSPA4
20food allergy10.2CSN1S1, IL4
21primary hyperoxaluria10.1CSN1S1, MIP, AQP2
22lepromatous leprosy10.1IL4, IFNG
23autosomal dominant hyper ige syndrome10.1IL4, IFNG
24visceral leishmaniasis10.1IL4, IFNG
25cutaneous leishmaniasis10.1IL4, IFNG
26psoriatic arthritis10.1PTPN22, HLA-DRB1, HLA-C
27cerebrovascular disease10.1HSPA8, HSPA4, AQP4, MIP
28hydrocephalus10.1AQP1, AQP4
29cystic fibrosis10.1HSPA8, AQP2, AQP5, AQP1, MIP
30hepatitis b10.0CTLA4, IFNG, HLA-DRB1
31acute graft versus host disease10.0IFNG, IL4
32plasmodium falciparum malaria10.0HLA-DRB1, HSPA8, IFNG
33active cochleovestibular meniere's disease10.0
34active vestibular meniere's disease10.0
35active cochlear meniere's disease10.0
36hypoparathyroidism10.0
37lymphopenia10.0PTPN22, IFNG, IL4
38sezary's disease10.0IFNG, IL4
39leishmaniasis10.0HSPA4, IFNG, IL4
40tetanus10.0CSN1S1, IL4, IFNG
41myasthenia gravis10.0IFNG, IL4, CTLA4
42galactosemia10.0CTLA4, MIP, AQP1, AQP2, HLA-DRB1
43dermatitis10.0CTLA4, IL4, IFNG
44vascular disease10.0CSN1S1, HSPA4, HLA-C
45thyroiditis10.0HLA-C, HLA-DRB1, PTPN22, CTLA4
46allergic rhinitis10.0IFNG, IL4, CTLA4
47colitis10.0CTLA4, IL4, IFNG
48hyperthyroidism10.0CTLA4, PTPN22, HLA-DRB1, HLA-C
49allergic asthma10.0IFNG, IL4, CTLA4
50pulmonary tuberculosis9.9IL4, IFNG, HLA-DRB1

Graphical network of the top 20 diseases related to Meniere's Disease:



Diseases related to meniere's disease

Symptoms for Meniere's Disease

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Symptoms by clinical synopsis from OMIM:

156000

Clinical features from OMIM:

156000

HPO human phenotypes related to Meniere's Disease:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 hearing impairment HP:0000365
3 vertigo HP:0002321

Drugs & Therapeutics for Meniere's Disease

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Drug clinical trials:

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Genetic Tests for Meniere's Disease

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Anatomical Context for Meniere's Disease

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MalaCards organs/tissues related to Meniere's Disease:

32
Testes, Bone, Skin

Animal Models for Meniere's Disease or affiliated genes

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Publications for Meniere's Disease

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Articles related to Meniere's Disease:

(show top 50)    (show all 212)
idTitleAuthorsYear
1
Endolymphatic hydrops revealed by magnetic resonance imaging in patients with atypical Meniere's disease. (23106485)
2013
2
Vestibular abnormality in patients with Meniere's disease and migrainous vertigo. (23145969)
2013
3
Factors affecting postural instability in Meniere's disease. (23980034)
2013
4
Comparison of intratympanic methylprednisolone and gentamicin for Meniere's disease may be misleading. (23818540)
2013
5
Vestibular evoked myogenic potentials to sound and vibration: characteristics in vestibular migraine that enable separation from Meniere's disease. (22259049)
2012
6
Tenotomy of the middle ear muscles causes a dramatic reduction in vertigo attacks and improves audiological function in definite Meniere's disease. (22201453)
2012
7
Meniere's disease: an evidence based approach to assessment and management. (22257041)
2012
8
Analysis of auditory and vestibular function in patients with unilateral Meniere's disease. (23039188)
2012
9
Is allergy related to Meniere's disease? (22457225)
2012
10
Comparison of noninvasive evaluation of endolymphatic hydrops in Meniere's disease and endolymphatic space in healthy volunteers using magnetic resonance imaging. (22201445)
2012
11
Endolymphatic hydrops in Meniere's disease detected by MRI after intratympanic administration of gadolinium: comparison with sudden deafness. (21344957)
2011
12
Blockage of longitudinal flow in Meniere's disease: A human temporal bone study. (21319945)
2011
13
Meniere's disease: new concepts, new treatments. (22413647)
2011
14
In vivo visualization of endolyphatic hydrops in patients with Meniere's disease: correlation with audiovestibular function. (21431434)
2011
15
Associations between HLA-C alleles and definite Meniere's disease. (21625020)
2011
16
The association of the plasma vasopressin level during attacks with a prognosis of Meniere's disease. (20053151)
2010
17
Magnetic resonance imaging of the inner ear in Meniere's disease. (20713245)
2010
18
Changes in endolymphatic hydrops in a patient with Meniere's disease observed using magnetic resonance imaging. (19540682)
2010
19
A serious refractive multifocal intraocular lens complication in Meniere's disease. (20375750)
2010
20
Genetic investigations of Meniere's disease. (20713249)
2010
21
Premenstrual exacerbation of Meniere's disease revisited. (20713242)
2010
22
A comparison of three methods of using transtympanic electrocochleography for the diagnosis of Meniere's disease: click summating potential measurements, tone burst summating potential amplitude measurements, and biasing of the summating potential using a low frequency tone. (19396716)
2010
23
Hypothetical mechanism for vertigo in Meniere's disease. (20713241)
2010
24
Blockage of reuniting duct in Meniere's disease. (19585278)
2010
25
Analysis of hearing preservation after endolymphatic mastoid sac surgery for Meniere's disease. (20131368)
2010
26
Does migraine-associated vertigo share a common pathophysiology with Meniere's disease? Study with vestibular-evoked myogenic potential. (19911463)
2009
27
Histopathological and ultrastructural analysis of vestibular endorgans in Meniere's disease reveals basement membrane pathology. (19493357)
2009
28
Changes in the characteristics of definite Meniere's disease over time in Japan: a long-term survey by the Peripheral Vestibular Disorder Research Committee of Japan, formerly the Meniere's Disease Research Committee of Japan. (18607900)
2009
29
Impact of bilaterality and headache on health-related quality of life in Meniere's disease. (19663372)
2009
30
Aquaporins as potential drug targets for Meniere's disease and its related diseases. (19096777)
2009
31
Utility of immunologic parameters in the evaluation of Meniere's disease. (19863304)
2009
32
Amplitude and area ratios of summating potential/action potential (SP/AP) in Meniere's disease. (19003588)
2009
33
High-dose intratympanic gentamicin instillations for treatment of Meniere's disease: long-term results. (19922092)
2009
34
Oculomotor findings mimicking a cerebellar disorder and postural control in severe Meniere's disease. (18501541)
2009
35
Inheritance of Meniere's disease in the Finnish population. (17224529)
2007
36
Implication of vibration induced nystagmus in Meniere's disease. (17882583)
2007
37
Non-specific immunological determinations in Meniere's disease: any role in clinical practice? (17033831)
2007
38
Histopathology of the vestibular end organs after intratympanic gentamicin failure for Meniere's disease. (17364327)
2007
39
Meniere's disease: rare or underdiagnosed among Africans. (17610076)
2007
40
Evolution of audiometric pattern in Meniere's disease: long-term survey of 380 cases evaluated according to the 1995 guidelines of the American Academy of Otolaryngology-Head and Neck Surgery. (16527013)
2006
41
Effects of intratympanic injection of latanoprost in Meniere's disease: a randomized, placebo-controlled, double-blind, pilot study. (16143197)
2005
42
The role of vestibular rehabilitation in the treatment of Meniere's disease. (16143175)
2005
43
Endolymphatic sac decompression as a treatment for Meniere's disease. (16094123)
2005
44
Meniere's disease or migraine? The clinical significance of fluctuating hearing loss with vertigo. (15897428)
2005
45
Retrosigmoid approach for vestibular neurectomy in Meniere's disease. (15618995)
2005
46
Meniere's Disease and Migraine. (15897429)
2005
47
Meniere's disease. (15865674)
2004
48
Postural instability in Meniere's disease. (15156095)
2004
49
Mutations in the COCH gene are a frequent cause of autosomal dominant progressive cochleo-vestibular dysfunction, but not of Meniere's disease. (14512963)
2003
50
Evaluation of vertigo; differential diagnosis of Meniere's disease, acute labyrinthitis, tumors of the cerebellopontine angle and insufficiency of the basilar artery. (13614054)
1958

Variations for Meniere's Disease

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Expression for genes affiliated with Meniere's Disease

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Expression patterns in normal tissues for genes affiliated with Meniere's Disease

Search GEO for disease gene expression data for Meniere's Disease.

Pathways for genes affiliated with Meniere's Disease

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Pathways related to Meniere's Disease according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL4, IFNG
2
Show member pathways
9.6HLA-DRB1, PTPN22, CTLA4
39.5CTLA4, HLA-DRB1, HLA-C
4
Show member pathways
9.5PARP1, TLR10, HLA-C
5
Show member pathways
9.4IL4, IFNG, TLR10
69.4CTLA4, IFNG, HLA-DRB1
7
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.4CTLA4, IL4, IFNG
8
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.3HLA-DRB1, IFNG, IL4
99.3IL4, IFNG, HLA-DRB1
10
Show member pathways
9.2IFNG, HSPA4, HSPA8
119.2AQP4, AQP1, IFNG, IL4
12
Show member pathways
9.1IL4, IFNG, TLR10, HLA-DRB1
139.1HLA-C, HLA-DRB1, HSPA8, IFNG
14
Show member pathways
9.0HLA-DRB1, HSPA8, IFNG, IL4
15
Show member pathways
8.7HLA-C, HLA-DRB1, HSPA8, IFNG, IL4
16
Show member pathways
8.6MIP, AQP7, AQP6, AQP2, AQP4, AQP5
17
Show member pathways
8.6AQP7, AQP6, AQP2, AQP4, AQP5, AQP1
18
Show member pathways
8.3HSPA4, AQP7, AQP6, AQP2, AQP4, AQP5
19
Show member pathways
7.9HLA-C, HLA-DRB1, HSPA8, HSPA4, IFNG, IL4

Compounds for genes affiliated with Meniere's Disease

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Compounds related to Meniere's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1hg2+4410.4AQP1, MIP
2hgcl24410.2MIP, AQP1, AQP2
3chloride449.7AQP2, MIP, AQP4, AQP1
4con a449.7IFNG, CTLA4, IL4
5betaseron449.6IL4, IFNG
6manumycin449.6PARP1, HSPA4, HSPA8
7silver449.6HSPA4, AQP1, MIP, HSPA8
8il 10449.5IFNG, IL4, CTLA4
93-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.5HSPA8, HSPA4, PARP1
10mercury449.5MIP, AQP2, AQP1, AQP4, HSPA4
11rotenone449.5PARP1, HSPA4, HSPA8
12glatiramer acetate44 1110.4IFNG, CTLA4, IL4, HLA-DRB1
13infliximab44 50 1111.4CTLA4, IFNG, IL4
14s-nitroso-n-acetylpenicillamine449.4HSPA4, PARP1, IFNG
15tacrolimus44 50 1111.4MIP, IL4, IFNG, CTLA4
16arsenite44 2410.3HSPA8, HSPA4, PARP1, MIP
17hg2+289.3AQP7, MIP, AQP1, AQP5, AQP2, AQP6
18hydrogen44 2410.3HSPA4, AQP2, MIP, AQP1, HSPA8
19nacl449.2AQP2, AQP1, MIP, CSN1S1
20cyclosporin a44 28 6111.2AQP2, IL4, IFNG, HSPA8, CTLA4
21herbimycin a44 6110.2HSPA8, HSPA4, IFNG, IL4
22potassium44 24 1111.2MIP, AQP1, HSPA8, AQP4, AQP2, HSPA4
23sodium44 2410.2AQP2, MIP, AQP1, AQP4, HSPA4, HSPA8
24prostaglandin449.1PTGFR, HSPA4, HSPA8, AQP2
25valine449.0AQP1, HSPA8, CSN1S1, HLA-DRB1
26sodium nitroprusside449.0HSPA4, AQP1, HSPA8, CSN1S1
27urea44 24 1110.9MIP, CSN1S1, AQP1, HSPA8, AQP2, AQP4
28melphalan44 50 1110.9HSPA4, CTLA4, IL4, PARP1, IFNG
29nitric oxide44 24 1110.9HSPA8, MIP, IFNG, AQP1, AQP2, HSPA4
30quercetin44 61 24 1111.8HSPA4, HSPA8, PARP1, CSN1S1
31rantes448.8CTLA4, IL4, HSPA8, IFNG
32steroid448.7PTGFR, AQP1, CTLA4, HSPA4, AQP2, HSPA8
33mannitol44 119.6AQP4, HSPA4, HSPA8, AQP1, MIP, CSN1S1
34polyacrylamide448.5CSN1S1, HSPA8, HSPA4, CTLA4
35methionine448.5HSPA4, HSPA8, AQP2, AQP1, CSN1S1, CTLA4
36creatinine448.5HSPA8, CSN1S1, AQP1, AQP2, HSPA4
37ly294002448.4PARP1, CTLA4, HSPA4, CSN1S1, IL4
38vegf448.4IL4, HSPA4, HSPA8, AQP1, PARP1, MIP
39adenylate448.4HSPA8, HSPA4, PTGFR, AQP2, IL4
40allergens448.3CTLA4, HLA-DRB1, IFNG, IL4, CSN1S1, HSPA8
41sb 20358044 619.3IL4, HSPA4, PARP1, CSN1S1, IFNG
42alanine448.1HLA-DRB1, AQP2, HSPA8, CSN1S1, CTLA4, HSPA4
43pge2448.1IFNG, AQP2, PTGFR, HSPA8, CSN1S1, IL4
44atp44 289.1HSPA4, HSPA8, HLA-DRB1, CSN1S1, MIP, PARP1
45arginine448.0IFNG, HLA-DRB1, PTPN22, AQP2, IL4, AQP1
46dexamethasone44 50 28 1111.0MIP, IFNG, IL4, PARP1, AQP1, AQP4
47glutamate447.9HSPA8, HSPA4, PTPN22, AQP4, MIP, CSN1S1
48tyrosine447.6CTLA4, CSN1S1, HSPA8, HLA-DRB1, PTPN22, PTGFR
49glycerol44 24 119.4AQP5, AQP6, HSPA4, HSPA8, AQP2, AQP4
50cysteine447.2MIP, IFNG, IL4, CSN1S1, PARP1, AQP1

GO Terms for genes affiliated with Meniere's Disease

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Cellular components related to Meniere's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.8AQP1, AQP4, AQP2
2transport vesicle membraneGO:0306589.3HLA-DRB1, AQP6, AQP2
3external side of plasma membraneGO:0098978.8HLA-DRB1, AQP4, IFNG, IL4, CTLA4
4extracellular vesicular exosomeGO:0700628.0HLA-C, HLA-DRB1, HSPA8, HSPA4, AQP2, AQP5
5integral component of plasma membraneGO:0058877.4CTLA4, HLA-C, HLA-DRB1, PTGFR, AQP7, AQP6
6plasma membraneGO:0058867.1PTGFR, HSPA8, TLR10, HLA-DRB1, HLA-C, AQP7

Biological processes related to Meniere's Disease according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1renal water transportGO:00309710.3AQP1, AQP2
2cellular response to copper ionGO:07128010.3AQP1, AQP2
3renal water absorptionGO:07029510.3AQP4, AQP7
4multicellular organismal water homeostasisGO:05089110.2AQP4, AQP1
5pancreatic juice secretionGO:03015710.1AQP5, AQP1
6glycerol transportGO:01579310.1AQP7, AQP2, AQP1
7carbon dioxide transportGO:01567010.1AQP4, AQP5, AQP1
8cell volume homeostasisGO:00688410.0AQP1, AQP2
9cellular response to mercury ionGO:07128810.0IL4, AQP1, AQP2
10positive regulation of isotype switching to IgG isotypesGO:0483049.9IFNG, IL4
11positive regulation of MHC class II biosynthetic processGO:0453489.8IFNG, IL4
12odontogenesisGO:0424769.8AQP1, AQP5, AQP6
13positive regulation of chemokine biosynthetic processGO:0450809.7IL4, IFNG
14defense response to protozoanGO:0428329.6IL4, IFNG
15female pregnancyGO:0075659.6AQP2, AQP4, IL4
16interferon-gamma-mediated signaling pathwayGO:0603339.6IFNG, HLA-DRB1, HLA-C
17excretionGO:0075889.4AQP7, AQP6, AQP2, AQP4, AQP5
18immune responseGO:0069559.2HLA-C, HLA-DRB1, TLR10, IL4, CTLA4
19water transportGO:0068339.0MIP, AQP1, AQP5, AQP4, AQP2, AQP6
20transmembrane transportGO:0550858.9AQP7, AQP6, AQP2, AQP4, AQP5, AQP1
21response to drugGO:0424938.9IL4, IFNG, AQP1, AQP7

Molecular functions related to Meniere's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complex bindingGO:0230269.8HSPA8, HLA-DRB1
2glycerol transmembrane transporter activityGO:0151689.7AQP1, AQP2
3water transmembrane transporter activityGO:0053729.7AQP2, AQP4, AQP1
4water channel activityGO:0152509.1MIP, AQP1, AQP5, AQP6, AQP7

Products for genes affiliated with Meniere's Disease

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  • Antibodies
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Sources for Meniere's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet