Aliases & Classifications for Meniere's Disease

MalaCards integrated aliases for Meniere's Disease:

Name: Meniere's Disease 12 50 25 41 14 50 25
Meniere Disease 12 50 25 42 69
Otogenic Vertigo 12 25
Meniere's Syndrome 25
Ménière's Vertigo 25
Auditory Vertigo 25
Menieres Disease 52
Mnire's Vertigo 12
Ménière Disease 25
Vertigo, Aural 69
Aural Vertigo 25

Characteristics:

HPO:

32
meniere's disease:
Inheritance autosomal dominant inheritance
Onset and clinical course incomplete penetrance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Ear diseases


Summaries for Meniere's Disease

MedlinePlus : 41 meniere's disease is a disorder of the inner ear. it can cause severe dizziness, a roaring sound in your ears called tinnitus, hearing loss that comes and goes and the feeling of ear pressure or pain. it usually affects just one ear. it is a common cause of hearing loss. attacks of dizziness may come on suddenly or after a short period of tinnitus or muffled hearing. some people have single attacks of dizziness once in a while. others may have many attacks close together over several days. some people with meniere's disease have "drop attacks" during which the dizziness is so bad they lose their balance and fall. scientists don't yet know the cause. they think that it has to do with the fluid levels or the mixing of fluids in the canals of your inner ear. doctors diagnose it based on a physical exam and your symptoms. a hearing test can check to see how it has affected your hearing. there is no cure. treatments include medicines to control dizziness, limiting salt in your diet, and taking water pills. a device that fits into the outer ear and delivers air pulses to the middle ear can help. severe cases may require surgery. nih: national institute on deafness and other communication disorders

MalaCards based summary : Meniere's Disease, also known as meniere disease, is related to active cochleovestibular meniere's disease and active vestibular meniere's disease, and has symptoms including tinnitus, hearing impairment and vertigo. An important gene associated with Meniere's Disease is FAM136A (Family With Sequence Similarity 136 Member A), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Betahistine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and bone, and related phenotype is hearing/vestibular/ear.

NIH Rare Diseases : 50 ménière's disease is an abnormality of the inner ear. signs and symptoms may include disabling vertigo or severe dizziness lasting from minutes to hours; tinnitus or a roaring sound in the ears; fluctuating hearing loss; and the sensation of pressure or pain in the affected ear. a small percentage of people have drop attacks. the disorder usually affects only one ear, but some people develop symptoms in both ears many years after their initial diagnosis. although the exact cause of ménière's disease is unknown, the symptoms are thought to be associated with a change in fluid volume within a portion of the inner ear known as the labyrinth. treatment may include medications or surgery depending on the severity of the condition. last updated: 12/21/2016

Disease Ontology : 12 A vestibular disease characterized by vertigo, low-pitched tinnitus and hearing loss.

Wikipedia : 72 Ménière\'s disease (MD) is a disorder of the inner ear that is characterized by episodes of feeling like... more...

Related Diseases for Meniere's Disease

Diseases related to Meniere's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
id Related Disease Score Top Affiliating Genes
1 active cochleovestibular meniere's disease 10.9
2 active vestibular meniere's disease 10.9
3 active cochlear meniere's disease 10.9
4 kanzaki disease 10.8
5 carotid artery thrombosis 10.6 AQP2 AQP4
6 hypersplenism 10.6 AQP1 AQP4
7 microcephaly, cerebellar hypoplasia, and cardiac conduction defect syndrome 10.6 AQP1 AQP4
8 hyperimmunoglobulin syndrome 10.6 AQP1 FAM136A
9 sudden sensorineural hearing loss 10.5 AQP1 AQP4
10 vagina leiomyosarcoma 10.5 AQP1 AQP3
11 ectodermal dysplasia/short stature syndrome 10.5 DTNA FAM136A
12 mental retardation, autosomal dominant 31 10.5 DTNA FAM136A
13 lens disease 10.5 AQP1 AQP4
14 idiopathic juxtafoveal retinal telangiectasia 10.5 AQP1 AQP2
15 cascade stomach 10.3 AQP1 AQP3
16 laron dwarfism 10.3 AQP5 MIP
17 night blindness 10.2 AQP1 AQP3
18 bardet-biedl syndrome 17 10.2 AQP4 MIP
19 newborn respiratory distress syndrome 10.2 AQP1 AQP4
20 tooth agenesis, selective, 3 10.2 COCH FAM136A SLC44A2
21 efemp2-related cutis laxa 10.1 AQP1 AQP4 MIP
22 calciphylaxis 10.1 AQP1 AQP4 MIP
23 congenital syphilis 10.1 AQP2 AQP5 COCH FAM136A
24 viral laryngitis 10.1 AQP2 AQP5 COCH FAM136A
25 idiopathic corneal edema 10.1 AQP3 MIP
26 cervix squamous papilloma 10.0 AQP1 AQP4
27 prediabetes syndrome 9.9 AQP1 AQP2 AQP3 MIP
28 venous insufficiency 9.7
29 hypoparathyroidism 9.7
30 palmoplantar keratoderma, bothnian type 9.6 AQP1 AQP2 AQP3 AQP4 MIP
31 interstitial keratitis 5.4 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7

Comorbidity relations with Meniere's Disease via Phenotypic Disease Network (PDN):


Active Vestibular Meniere's Disease Anxiety Disorder
Esophagitis Hypertension, Essential
Hypothyroidism Ischemic Heart Disease
Labyrinthitis Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Meniere's Disease:



Diseases related to Meniere's Disease

Symptoms & Phenotypes for Meniere's Disease

Human phenotypes related to Meniere's Disease:

32
id Description HPO Frequency HPO Source Accession
1 tinnitus 32 HP:0000360
2 hearing impairment 32 HP:0000365
3 vertigo 32 HP:0002321

UMLS symptoms related to Meniere's Disease:


coughing, snoring, vertigo, sore throat, vertigo/dizziness, equilibration disorder

MGI Mouse Phenotypes related to Meniere's Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.1 AQP1 AQP3 AQP4 AQP5 COCH SLC44A2

Drugs & Therapeutics for Meniere's Disease

Drugs for Meniere's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betahistine Approved Phase 4,Phase 2 5638-76-6 2366
2
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
3
Cisplatin Approved Phase 4 15663-27-1 84093 441203 2767
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
6
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
7
Nicotinamide Approved, Nutraceutical Phase 4 98-92-0 936
8 Tocopherol Approved, Nutraceutical Phase 4
9
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
10
Histamine Phosphate Phase 4,Phase 2 51-74-1 65513
11 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
12 Vasodilator Agents Phase 4,Phase 2
13 Antiemetics Phase 4,Phase 2,Phase 3
14 Antimetabolites Phase 4,Phase 3
15 Antioxidants Phase 4,Phase 1,Phase 2
16 Autonomic Agents Phase 4,Phase 2,Phase 3
17 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
18 Hypolipidemic Agents Phase 4
19 Lipid Regulating Agents Phase 4
20 Micronutrients Phase 4
21 Nicotinic Acids Phase 4
22 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
23 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
24 Tocopherols Phase 4
25 Tocotrienols Phase 4
26 Trace Elements Phase 4
27 Vitamin B Complex Phase 4
28 Vitamins Phase 4
29 Pharmaceutical Solutions Phase 4,Phase 2
30 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
31 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
32 BB 1101 Phase 4,Phase 3,Phase 2
33 Dexamethasone 21-phosphate Phase 4
34 Dexamethasone acetate Phase 4,Phase 3,Phase 2 1177-87-3
35 glucocorticoids Phase 4,Phase 2,Phase 3
36 HIV Protease Inhibitors Phase 4
37 Hormone Antagonists Phase 4,Phase 2,Phase 3
38 Hormones Phase 4,Phase 2,Phase 3
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
40
protease inhibitors Phase 4
41 Folate Nutraceutical Phase 4
42 Tocotrienol Investigational, Nutraceutical Phase 4 6829-55-6
43 Vitamin B3 Nutraceutical Phase 4
44 Vitamin B9 Nutraceutical Phase 4
45
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
46
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
47
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
48
Famciclovir Approved Phase 3 104227-87-4 3324
49 Acyclovir Phase 2, Phase 3
50 Anti-Infective Agents Phase 2, Phase 3

Interventional clinical trials:

(show all 35)

id Name Status NCT ID Phase Drugs
1 Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomy Completed NCT00160238 Phase 4 Betahistine 24 mg bid (Betaserc)
2 Efficacy of Local Overpressure Treatment for Meniere's Disease Completed NCT00831688 Phase 4
3 Effect of Stellate Ganglion Block on Meniere's Disease Completed NCT01574313 Phase 4 0.25mg, fludiazine;25mg cephadol@ (diphenidol);200mg kentons@ (tocopherol nicotinate).
4 Isobide Solution and Meniace Tablets Compared to Monotherapy With Meniace Tablets Completed NCT02718846 Phase 4 Meniace;Isobide
5 Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone Treatment Completed NCT01372904 Phase 4 Dexamethasone Phosphate
6 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease Recruiting NCT02530931 Phase 4 Gadolinium
7 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS) Recruiting NCT02529475 Phase 4 Gadoteric acid
8 Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Disease Unknown status NCT01729767 Phase 2, Phase 3 Acyclovir;Placebo
9 Study of OTO-104 in Subjects With Unilateral Meniere's Disease Completed NCT02612337 Phase 3 OTO-104;Placebo
10 Clinical Trial of Traditional Chinese Diaoshi Jifa Therapy of Meniere's Disease Completed NCT01454726 Phase 3
11 Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Disease Completed NCT00802529 Phase 2, Phase 3 Methylprednisolone;Gentamicin
12 Study of Lamotrigine to Treat Ménière's Disease Completed NCT02158585 Phase 3 Lamotrigine;Placebo
13 Famvir for Treatment of Hearing in Unilateral Meniere's Disease Terminated NCT01526408 Phase 3 Famciclovir;Placebo
14 Study of OTO-104 in Subjects With Unilateral Meniere's Disease Terminated NCT02717442 Phase 3 OTO-104;Placebo
15 A 6-Month Extension Study of OTO-104 in Meniere's Disease Terminated NCT02768662 Phase 3 OTO-104
16 A 6-Month Extension Study of OTO-104 in Meniere's Disease Terminated NCT02706730 Phase 3 OTO-104
17 OTO-104 for the Treatment of Meniere's Disease Completed NCT01412177 Phase 2 OTO-104;Placebo
18 Sildenafil For Meniere's Disease Completed NCT00145483 Phase 2 Sildenafil
19 Study to Evaluate SPI-1005 in Adults With Meniere's Disease Completed NCT02603081 Phase 1, Phase 2 SPI-1005
20 A 1-Year Safety Study of OTO-104 in Subjects With Unilateral Meniere's Disease Located in United Kingdom Completed NCT02265393 Phase 2 OTO-104;Placebo
21 Efficacy and Tolerability Study of Betahistine to Ameliorate Antipsychotic Associated Weight Gain in Adolescents and Young Adults Completed NCT00709202 Phase 2 Betahistine
22 The Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2 gevokizumab
23 A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2 Anakinra
24 Latanoprost for the Treatment of Menière's Disease Active, not recruiting NCT01973114 Phase 2 Latanoprost
25 Open Label Study of OTO-104 in Subjects With Meniere's Disease Terminated NCT02740387 Phase 2 OTO-104
26 OTO-104 for Meniere's Disease Completed NCT01084525 Phase 1 OTO-104 (steroid) 3 mg;Placebo;OTO-104 (steroid) 12 mg
27 Vasopressin and V2 Receptor in Meniere's Disease Completed NCT00599560
28 Effects of Endolymphatic Sac Drainage With Steroids for Meniere’s Disease Completed NCT00500474
29 Magnetic Resonance Imaging Evaluation of Inner Ear Pathology Using Intra-Tympanic Contrast Agent Completed NCT02080312 Magnevist (gadopentetate dimeglumine)
30 Effectiveness of Betaserc® (Betahistine Dihydrochloride) in Patients With Vestibular Vertigo in Routine Practice Completed NCT01759251
31 Stress Management Therapy for Meniere's Disease Recruiting NCT01099046
32 Comparison of 3 Methods to Diagnose Endolymphatic Hydrops in Meniere's Disease Recruiting NCT03215420
33 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Active, not recruiting NCT02309099
34 Herbal Medication (Gongjin-dan) for Chronic Dizziness Not yet recruiting NCT03219515 Gongjin-Dan;Placebo
35 Unilateral Meniere Disease: Can Double Dose Gadolinium and Delayed Imaging Make the Diagnosis? Withdrawn NCT02371798 Gadopentetate dimeglumine

Search NIH Clinical Center for Meniere's Disease

Cochrane evidence based reviews: meniere disease

Genetic Tests for Meniere's Disease

Anatomical Context for Meniere's Disease

MalaCards organs/tissues related to Meniere's Disease:

39
Testes, Brain, Bone, Skin

Publications for Meniere's Disease

Articles related to Meniere's Disease:

(show top 50) (show all 258)
id Title Authors Year
1
Concomitant diseases and their effect on disease prognosis in Meniere's disease: diabetes mellitus identified as a negative prognostic factor. ( 28914106 )
2017
2
The theory of autoimmunity in Meniere's disease is lacking evidence. ( 28784462 )
2017
3
Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere's disease. ( 27876815 )
2017
4
Selective Window Application of Gentamicin+ Dexamethasone in Meniere's Disease. ( 28716762 )
2017
5
Meniere's Disease and Vestibular Migraine: Updates and Review of the Literature. ( 28811849 )
2017
6
Short Term Results of Intra Tympanic Gentamicin and Dexamethasone on Hearing and Tinnitus in Meniere's disease: A Case Control Study. ( 28723597 )
2017
7
Ictal downbeat nystagmus in bilateral Meniere's disease. ( 28821951 )
2017
8
Evidence of surgical treatments for intractable Meniere's disease. ( 28760332 )
2017
9
The clinical characteristics and audiogram in 103 Meniere's disease patients with and without vestibular migraine. ( 28742261 )
2017
10
Abnormal Cervical Vestibular-Evoked Myogenic Potentials Predict Evolution of Isolated Recurrent Vertigo into Meniere's Disease. ( 28928714 )
2017
11
Degeneration of the vestibular nerve in unilateral Meniere's disease evaluated by galvanic vestibular-evoked myogenic potentials. ( 28719825 )
2017
12
Endolymphatic hydrops in patients with unilateral and bilateral Meniere's disease. ( 27564645 )
2016
13
Is gentamycin delivery via sustained-release vehicles a safe and effective treatment for refractory Meniere's disease? A critical analysis of published interventional studies. ( 27623821 )
2016
14
Meniere's disease. ( 27170426 )
2016
15
Repeated courses of intratympanic dexamethasone injection are effective for intractable Meniere's disease. ( 27650470 )
2016
16
Meniere's disease. ( 27170253 )
2016
17
SLC44A2 single nucleotide polymorphisms, isoforms, and expression: Association with severity of Meniere's disease? ( 27829169 )
2016
18
A novel missense variant in PRKCB segregates low-frequency hearing loss in an autosomal dominant family with Meniere's disease. ( 27329761 )
2016
19
HLA-Cw Allele Frequency in Definite Meniere's Disease Compared to Probable Meniere's Disease and Healthy Controls in an Iranian Sample. ( 27602337 )
2016
20
Triple semicircular canal plugging: a novel modality for the treatment of intractable Meniere's disease. ( 27434132 )
2016
21
Utilisation of multi-frequency VEMPs improves diagnostic accuracy for Meniere's disease. ( 27422626 )
2016
22
Incidence of Hypothyroidism in Meniere's Disease. ( 27437251 )
2016
23
Acupuncture Points Stimulation for Meniere's Disease/Syndrome: A Promising Therapeutic Approach. ( 27547229 )
2016
24
Steroid injections through the eardrum reduce dizziness in Meniere's disease, study finds. ( 27864211 )
2016
25
Endolymphatic space size in patients with Meniere's disease and healthy controls. ( 27080254 )
2016
26
Re: Meniere's disease: Importance of socioeconomic and environmental factors. ( 27038820 )
2016
27
Volumetric measurements of the inner ear in patients with Meniere's disease using three-dimensional magnetic resonance imaging. ( 27187035 )
2016
28
A thin line between Meniere's disease and spontaneous intracranial hypotension syndrome. ( 26827704 )
2016
29
MRI of endolymphatic hydrops in patients with Meniere's disease: a case-controlled study with a simplified classification based on saccular morphology. ( 27999985 )
2016
30
Treatment of Meniere's disease with intratympanic dexamethazone plus high dosage of betahistine. ( 27178513 )
2016
31
Meniere's disease: importance of socioeconomic and environmental factors. ( 25771842 )
2015
32
Sex-specific association of RANTES gene -403 variant in Meniere's disease. ( 24961438 )
2015
33
A Puzzle of Vestibular Physiology in a Meniere's Disease Acute Attack. ( 26167320 )
2015
34
Delayed intravenous contrast-enhanced 3D FLAIR MRI in Meniere's disease: correlation of quantitative measures of endolymphatic hydrops with hearing. ( 25457542 )
2015
35
The correlation between symptoms of definite Meniere's disease and endolymphatic hydrops visualized by magnetic resonance imaging. ( 26333096 )
2015
36
Comparative Study of Endolymphatic Sac Decompression and Vestibular Neurectomy in Intractable Meniere's Disease. ( 25621233 )
2015
37
Meniere's disease: histopathology, cytochemistry, and imaging. ( 25766597 )
2015
38
Bilateral Meniere's disease assessed by an inner ear test battery. ( 25649882 )
2015
39
Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease. ( 26343803 )
2015
40
Application of Vestibular Spontaneous Response as a Diagnostic Aid for Meniere's Disease. ( 26334355 )
2015
41
Effects of posterior tympanotomy with steroids at round window on hearing recovery after revision surgery for intractable Meniere's disease. ( 25762028 )
2015
42
Migraine features in patients with Meniere's disease. ( 26109273 )
2015
43
Diffuse systemic sclerosis presenting as Meniere's disease-like symptoms as part of autoimmune inner ear disease. ( 26040060 )
2015
44
One-third of vertiginous episodes during the follow-up period are caused by benign paroxysmal positional vertigo in patients with Meniere's disease. ( 25166020 )
2014
45
Three-dimensional cone beam computed tomography imaging of the membranous labyrinth in patients with Meniere's disease. ( 25220723 )
2014
46
Autoimmunity as a Candidate for the Etiopathogenesis of Meniere's Disease: Detection of Autoimmune Reactions and Diagnostic Biomarker Candidate. ( 25330336 )
2014
47
Meniere's disease. ( 25391837 )
2014
48
Correction: Effect of Intratympanic Dexamethasone on Controlling Tinnitus and Hearing loss in Meniere's Disease. ( 25320707 )
2014
49
Intronic Variants in the NFKB1 Gene May Influence Hearing Forecast in Patients with Unilateral Sensorineural Hearing Loss in Meniere's Disease. ( 25397881 )
2014
50
Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere's disease. ( 25305078 )
2014

Variations for Meniere's Disease

ClinVar genetic disease variations for Meniere's Disease:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 FAM136A NM_032822.2(FAM136A): c.226C> T (p.Gln76Ter) single nucleotide variant Pathogenic rs690016537 GRCh37 Chromosome 2, 70527974: 70527974

Expression for Meniere's Disease

Search GEO for disease gene expression data for Meniere's Disease.

Pathways for Meniere's Disease

Pathways related to Meniere's Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
2
Show member pathways
12.69 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
3
Show member pathways
11.58 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
4 10.98 AQP2 AQP3 AQP4
5 10.92 AQP3 AQP5

GO Terms for Meniere's Disease

Cellular components related to Meniere's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.7 AQP1 AQP2 AQP4 AQP5 AQP7 MIP
2 plasma membrane GO:0005886 9.7 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
3 apical plasma membrane GO:0016324 9.56 AQP1 AQP2 AQP5 MIP
4 basal plasma membrane GO:0009925 9.4 AQP1 AQP5
5 basolateral plasma membrane GO:0016323 8.92 AQP1 AQP2 AQP3 AQP4
6 membrane GO:0016020 10.15 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
7 integral component of membrane GO:0016021 10.06 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7

Biological processes related to Meniere's Disease according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.83 AQP2 AQP4 AQP5 MIP
2 excretion GO:0007588 9.56 AQP2 AQP3 AQP5 AQP7
3 camera-type eye morphogenesis GO:0048593 9.55 AQP1 AQP5
4 cellular response to copper ion GO:0071280 9.54 AQP1 AQP2
5 odontogenesis GO:0042476 9.54 AQP1 AQP3 AQP5
6 multicellular organismal water homeostasis GO:0050891 9.51 AQP1 AQP4
7 pancreatic juice secretion GO:0030157 9.49 AQP1 AQP5
8 renal water absorption GO:0070295 9.46 AQP1 AQP3
9 renal water homeostasis GO:0003091 9.46 AQP1 AQP2 AQP3 AQP4
10 carbon dioxide transport GO:0015670 9.43 AQP1 AQP5
11 cellular response to mercury ion GO:0071288 9.4 AQP1 AQP2
12 renal water transport GO:0003097 9.32 AQP1 AQP2
13 glycerol transport GO:0015793 9.26 AQP1 AQP2 AQP3 AQP7
14 water transport GO:0006833 9.17 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
15 transport GO:0006810 10.08 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7

Molecular functions related to Meniere's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.55 AQP1 AQP2 AQP3 AQP4 MIP
2 glycerol channel activity GO:0015254 9.32 AQP3 AQP7
3 glycerol transmembrane transporter activity GO:0015168 9.26 AQP1 AQP2
4 water channel activity GO:0015250 9.17 AQP1 AQP2 AQP3 AQP4 AQP5 AQP7
5 water transmembrane transporter activity GO:0005372 9.13 AQP1 AQP2 AQP4

Sources for Meniere's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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