MCID: MNR008
MIFTS: 22

Menieres Disease malady

Summaries for Menieres Disease

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33MalaCards
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MalaCards: Menieres Disease is related to m�ni�re disease and hypoparathyroidism. An important gene associated with Menieres Disease is MIP (major intrinsic protein of lens fiber), and among its related pathways are Classical Kir channels and Regulation of Water Balance by Renal Aquaporins. The compounds hg2+ and pcmbs have been mentioned in the context of this disorder. Related mouse phenotype hearing/vestibular/ear.

Aliases & Classifications for Menieres Disease

Sources:
10DISEASES, 45Novoseek
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Aliases & Descriptions:

menieres disease 10 45


Related Diseases for Menieres Disease

Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Menieres Disease:



Diseases related to menieres disease

Clinical Features for Menieres Disease

Drugs & Therapeutics for Menieres Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Menieres Disease

Drug clinical trials:

Search ClinicalTrials for Menieres Disease

Search NIH Clinical Center for Menieres Disease

Search CenterWatch for Menieres Disease

Genetic Tests for Menieres Disease

Anatomical Context for Menieres Disease

Animal Models for Menieres Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Menieres Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.6AQP5, AQP4, AQP1, OCM2, FBXO2, COCH

Publications for Menieres Disease

Genetic Variations for Menieres Disease

Expression for genes affiliated with Menieres Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Menieres Disease

Search GEO for disease gene expression data for Menieres Disease.

Pathways for genes affiliated with Menieres Disease

Sources:
54Reactome, 12EMD Millipore, 52QIAGEN
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Compounds for genes affiliated with Menieres Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB
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Compounds related to Menieres Disease according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1hg2+4510.6MIP, AQP1
2pcmbs4510.5MIP, AQP1
3delta-12-pgj24510.5HSPA8, HSPA4
4hgcl24510.5AQP2, AQP1, MIP
5geranylgeranylacetone4510.5HSPA8, HSPA4
6ba2+2910.4KCNJ4, KCNJ14
7cs+2910.4KCNJ4, KCNJ14
8tetraethylammonium45 29 1112.4KCNJ4, MIP, AQP1
9cyclopentenone4510.4HSPA8, HSPA4
10p10756010.4KCNJ9, KCNJ4, KCNJ14
11bicarbonate4510.4AQP4, AQP1, MIP
12levcromakalim6010.4KCNJ9, KCNJ4, KCNJ14
13tertiapin-q6010.4KCNJ9, KCNJ4, KCNJ14
14h+ (extracellular)2910.4KCNJ14, KCNJ4
15vas-a4510.3AQP4, AQP1
16diazoxide45 60 29 1113.3KCNJ9, KCNJ4, KCNJ14
17silver4510.3HSPA8, HSPA4, MIP, AQP1
18cdcl24510.3HSPA4, HSPA8
19chloride4510.3MIP, AQP1, AQP2, AQP4
20glibenclamide45 29 50 6013.3KCNJ14, KCNJ4, KCNJ9
21urea45 11 2412.3HSPA8, MIP, AQP1, AQP2, AQP4
22prostaglandin4510.2AQP2, PTGFR, HSPA4, HSPA8
23mannitol45 1111.2AQP4, AQP1, MIP, HSPA4, HSPA8
24mercury4510.2HSPA4, MIP, AQP1, AQP2, AQP4
25methionine4510.2HSPA8, HSPA4, AQP1, AQP2
26mg2+2910.2KCNJ14, KCNJ4
27hydrogen45 2411.2AQP2, AQP1, MIP, HSPA4, HSPA8
28hg2+2910.1AQP7, MIP, AQP6, AQP1, AQP2, AQP5
29sodium45 2411.1HSPA8, HSPA4, MIP, AQP1, AQP2, AQP4
30cysteine4510.0COCH, HSPA8, MIP, AQP1, AQP2, AQP4
31sodium nitroprusside4510.0AQP1, HSPA4, HSPA8
32magnesium45 11 2411.9AQP2, OCM2, KCNJ14, KCNJ4, KCNJ9
33forskolin45 50 1111.9AQP7, AQP2, AQP1, PTGFR
34steroid459.7HSPA8, HSPA4, PTGFR, AQP1, AQP2
35glycerol45 11 2411.7HSPA8, HSPA4, MIP, AQP6, AQP1, AQP2
36potassium45 11 2411.6HSPA8, HSPA4, KCNJ9, KCNJ4, KCNE3, MIP
37dexamethasone45 50 29 1112.5HSPA4, MIP, AQP1, AQP2, AQP4

GO Terms for genes affiliated with Menieres Disease

Sources:
16Gene Ontology
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Cellular components related to Menieres Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.8AQP4, AQP2, AQP1, KCNJ4
2integral to plasma membraneGO:0058879.2MIP, PTGFR, AQP6, AQP1, AQP4, AQP5
3plasma membraneGO:0058868.9KCNJ9, KCNJ4, KCNJ14, MIP, PTGFR, AQP1

Biological processes related to Menieres Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1renal water transportGO:00309710.4AQP2, AQP1
2multicellular organismal water homeostasisGO:05089110.3AQP4, AQP1
3glycerol transportGO:01579310.3AQP1, AQP2, AQP7
4cellular response to mercury ionGO:07128810.3AQP2, AQP1
5carbon dioxide transportGO:01567010.3AQP1, AQP4, AQP5
6renal water absorptionGO:07029510.3AQP4, AQP7
7odontogenesisGO:04247610.2AQP6, AQP1, AQP5
8pancreatic juice secretionGO:03015710.2AQP5, AQP1
9cellular response to copper ionGO:07128010.1AQP2, AQP1
10excretionGO:00758810.1AQP6, AQP2, AQP4, AQP5, AQP7
11cell volume homeostasisGO:0068849.9AQP1, AQP2
12synaptic transmissionGO:0072689.9KCNJ14, KCNJ4, KCNJ9, HSPA8
13water transportGO:0068339.8AQP7, AQP5, AQP4, AQP2, AQP1, AQP6
14transmembrane transportGO:0550859.8MIP, AQP6, AQP1, AQP2, AQP4, AQP5

Molecular functions related to Menieres Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inward rectifier potassium channel activityGO:00524210.1KCNJ14, KCNJ4
2water transmembrane transporter activityGO:00537210.0AQP1, AQP2, AQP4
3glycerol transmembrane transporter activityGO:0151689.9AQP2, AQP1
4water channel activityGO:0152509.8AQP7, AQP5, AQP1, AQP6, MIP

Products for genes affiliated with Menieres Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Menieres Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet