MCID: MNR008
MIFTS: 25

Menieres Disease malady

Summaries for Menieres Disease

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32MalaCards
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MalaCards: Menieres Disease is related to meniere's disease and hypoparathyroidism. An important gene associated with Menieres Disease is MIP (major intrinsic protein of lens fiber), and among its related pathways are Classical Kir channels and Regulation of Water Balance by Renal Aquaporins. The compounds hg2+ and pcmbs have been mentioned in the context of this disorder. Related mouse phenotype hearing/vestibular/ear.

Aliases & Classifications for Menieres Disease

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10DISEASES, 44Novoseek
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Aliases & Descriptions:

menieres disease 10 44


Related Diseases for Menieres Disease

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Menieres Disease:



Diseases related to menieres disease

Clinical Features for Menieres Disease

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Drugs & Therapeutics for Menieres Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Menieres Disease

Search CenterWatch for Menieres Disease

Genetic Tests for Menieres Disease

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Anatomical Context for Menieres Disease

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Animal Models for Menieres Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Menieres Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.6AQP5, AQP4, AQP1, OCM2, FBXO2, COCH

Publications for Menieres Disease

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Genetic Variations for Menieres Disease

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Expression for genes affiliated with Menieres Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Menieres Disease

Search GEO for disease gene expression data for Menieres Disease.

Pathways for genes affiliated with Menieres Disease

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53Reactome, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Menieres Disease

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Menieres Disease according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1hg2+4410.6AQP1, MIP
2pcmbs4410.5AQP1, MIP
3hgcl24410.5MIP, AQP1, AQP2
4delta-12-pgj24410.5HSPA8, HSPA4
5geranylgeranylacetone4410.5HSPA8, HSPA4
6ba2+2810.4KCNJ14, KCNJ4
7cs+2810.4KCNJ4, KCNJ14
8tetraethylammonium44 28 1112.4MIP, KCNJ4, AQP1
9cyclopentenone4410.4HSPA8, HSPA4
10tertiapin-q5910.4KCNJ4, KCNJ14, KCNJ9
11bicarbonate4410.4AQP1, MIP, AQP4
12p10755910.4KCNJ9, KCNJ4, KCNJ14
13levcromakalim5910.4KCNJ9, KCNJ14, KCNJ4
14h+ (extracellular)2810.4KCNJ14, KCNJ4
15vas-a4410.3AQP4, AQP1
16diazoxide44 59 28 1113.3KCNJ14, KCNJ4, KCNJ9
17silver4410.3MIP, HSPA4, HSPA8, AQP1
18cdcl24410.3HSPA8, HSPA4
19chloride4410.3AQP1, AQP4, MIP, AQP2
20glibenclamide44 28 49 5913.3KCNJ14, KCNJ4, KCNJ9
21urea44 11 2412.3AQP1, HSPA8, MIP, AQP2, AQP4
22prostaglandin4410.2AQP2, HSPA8, HSPA4, PTGFR
23mannitol44 1111.2HSPA4, HSPA8, MIP, AQP1, AQP4
24mercury4410.2AQP1, MIP, HSPA4, AQP4, AQP2
25methionine4410.2HSPA8, AQP1, AQP2, HSPA4
26mg2+2810.2KCNJ14, KCNJ4
27hydrogen44 2411.2AQP1, MIP, HSPA4, AQP2, HSPA8
28hg2+2810.1AQP5, AQP6, AQP1, AQP2, AQP7, MIP
29sodium44 2411.1AQP4, AQP2, AQP1, MIP, HSPA4, HSPA8
30cysteine4410.0HSPA8, MIP, AQP2, AQP4, AQP1, COCH
31sodium nitroprusside4410.0HSPA8, HSPA4, AQP1
32magnesium44 11 2411.9OCM2, KCNJ14, KCNJ4, KCNJ9, AQP2
33forskolin44 49 1111.9PTGFR, AQP2, AQP7, AQP1
34steroid449.7HSPA8, AQP1, AQP2, PTGFR, HSPA4
35glycerol44 11 2411.7AQP2, AQP7, AQP5, HSPA4, AQP4, HSPA8
36potassium44 11 2411.6MIP, KCNJ9, AQP2, AQP4, AQP1, HSPA4
37dexamethasone44 49 28 1112.5AQP4, AQP2, AQP1, MIP, HSPA4

GO Terms for genes affiliated with Menieres Disease

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16Gene Ontology
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Cellular components related to Menieres Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.8KCNJ4, AQP1, AQP2, AQP4
2integral to plasma membraneGO:0058879.2AQP5, AQP4, AQP1, AQP6, PTGFR, MIP
3plasma membraneGO:0058868.9HSPA8, AQP5, AQP4, AQP2, AQP1, PTGFR

Biological processes related to Menieres Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1renal water transportGO:00309710.4AQP2, AQP1
2cellular response to mercury ionGO:07128810.4AQP2, AQP1
3carbon dioxide transportGO:01567010.3AQP5, AQP4, AQP1
4glycerol transportGO:01579310.3AQP1, AQP2, AQP7
5multicellular organismal water homeostasisGO:05089110.3AQP4, AQP1
6renal water absorptionGO:07029510.3AQP4, AQP7
7odontogenesisGO:04247610.2AQP5, AQP1, AQP6
8pancreatic juice secretionGO:03015710.2AQP1, AQP5
9cellular response to copper ionGO:07128010.1AQP1, AQP2
10excretionGO:00758810.1AQP7, AQP5, AQP4, AQP2, AQP6
11cell volume homeostasisGO:0068849.9AQP1, AQP2
12synaptic transmissionGO:0072689.9KCNJ14, HSPA8, KCNJ9, KCNJ4
13water transportGO:0068339.8AQP2, MIP, AQP6, AQP1, AQP4, AQP5
14transmembrane transportGO:0550859.8AQP7, AQP5, AQP2, AQP1, AQP6, MIP

Molecular functions related to Menieres Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inward rectifier potassium channel activityGO:00524210.1KCNJ4, KCNJ14
2water transmembrane transporter activityGO:00537210.0AQP4, AQP2, AQP1
3glycerol transmembrane transporter activityGO:0151689.9AQP1, AQP2
4water channel activityGO:0152509.8MIP, AQP6, AQP1, AQP5, AQP7

Products for genes affiliated with Menieres Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Menieres Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet