MCID: MNN006
MIFTS: 45

Meninges Hemangiopericytoma malady

Summaries for Meninges Hemangiopericytoma

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MalaCards: Meninges Hemangiopericytoma, also known as hemangiopericytoma of meninges, is related to hemangiopericytoma and meningioma. An important gene associated with Meninges Hemangiopericytoma is PTGDS (prostaglandin D2 synthase 21kDa (brain)), and among its related pathways are Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Adhesion. The compounds dihydrotestosterone and s 100 have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and lung, and related mouse phenotypes are embryogenesis and reproductive system.

Aliases & Classifications for Meninges Hemangiopericytoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

meninges hemangiopericytoma 8
hemangiopericytoma of meninges 8 60
meningeal hemangiopericytoma 8


External Ids:

Disease Ontology8 DOID:4957
SNOMED-CT56 277522009
NCIt39 C4660

Related Diseases for Meninges Hemangiopericytoma

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17GeneCards, 18GeneDecks
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Diseases related to Meninges Hemangiopericytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1hemangiopericytoma31.3MUC1, VIM, DES, IGF2
2meningioma30.6PTGDS, MUC1, IGF2, NF2, NCAM1, VIM
3hypoglycemia30.5IGF2, IGFBP3
4fibrous meningioma30.1NF2, MUC1
5retinoblastoma30.1RB1, E2F1
6mesenchymal chondrosarcoma30.1VIM, DES, MUC1
7chondrosarcoma30.1E2F1, VIM, DES, MUC1
8meningitis10.9
9hepatitis a10.2
10hepatitis10.2
11meningothelial meningioma10.1
12pancreatitis10.1
13neurilemmoma10.0NF2
14hemangioblastoma10.0MUC1
15myeloid leukemia10.0E2F1
16alzheimer's disease10.0PTGDS
17benign mesothelioma10.0NF2
18syringoma10.0MUC1
19infantile myofibromatosis10.0DES
20sertoli-leydig cell tumor10.0MUC1
21seminoma10.0IGF2
22lymphangioleiomyomatosis10.0DES
23infertility10.0PTGDS
24lipoma10.0DES
25hepatitis b10.0E2F1
26adenomatoid tumor10.0VIM
27cataract10.0NF2
28macular holes10.0PTGDS
29ductal carcinoma in situ10.0CDH1
30kidney cancer10.0CDH1
31esophageal cancer10.0CDH1
32multiple endocrine neoplasia10.0NF2
33anaplastic ependymoma10.0NF2, MUC1
34multiple myeloma10.0NCAM1
35hidradenoma10.0MUC1
36neuroblastoma10.0NCAM1
37angiomyolipoma10.0VIM, DES
38germ cell cancer10.0NCAM1
39perineurioma10.0VIM, MUC1
40fibromatosis10.0VIM, DES
41desmoplastic small round cell tumor10.0DES, MUC1
42schizophrenia10.0PTGDS
43glomus tumor10.0VIM, DES
44benign meningioma10.0NF2, EPB41L3
45secretory meningioma10.0MUC1, VIM
46epithelioid leiomyosarcoma10.0VIM, DES
47pseudosarcomatous fibromatosis10.0DES, VIM
48clear cell ependymoma10.0MUC1, VIM
49papilloma10.0E2F1, RB1
50choroid plexus papilloma10.0MUC1, IGF2

Graphical network of the top 20 diseases related to Meninges Hemangiopericytoma:



Diseases related to meninges hemangiopericytoma

Clinical Features for Meninges Hemangiopericytoma

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Drugs & Therapeutics for Meninges Hemangiopericytoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Meninges Hemangiopericytoma

Search CenterWatch for Meninges Hemangiopericytoma

Genetic Tests for Meninges Hemangiopericytoma

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Anatomical Context for Meninges Hemangiopericytoma

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32MalaCards
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MalaCards organs/tissues related to Meninges Hemangiopericytoma:

32
Bone, Liver, Lung, Heart, Adrenal gland

Animal Models for Meninges Hemangiopericytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Meninges Hemangiopericytoma:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.7VIM, NF2
2MP:00053899.1CDH1, NF2, E2F1
3MP:00053768.7IGF2, NF2, DES, MGMT, IGFBP3
4MP:00053698.5E2F1, RB1, IGF2, IGFBP3
5MP:00107718.5CDH1, PTGDS, RB1, E2F1, IGF2
6MP:00053708.4IGF2, RB1, MUC1, IGFBP3, NF2
7MP:00030128.3MGMT, RB1, IGF2, MUC1, PTGDS, CDH1
8MP:00053798.1EPB41L3, NF2, RB1, MGMT, E2F1
9MP:00053917.8VIM, E2F1, RB1, NF2, IGF2, MUC1
10MP:00053877.7E2F1, VIM, PTGDS, CDH1, IGF2, NF2
11MP:00020067.2NF2, PTGDS, E2F1, MGMT, RB1, EPB41L3
12MP:00053786.9CDH1, E2F1, RB1, VIM, NCAM1, NF2
13MP:00053866.6RB1, IGF2, EPB41L3, IGFBP3, NF2, NCAM1
14MP:00107686.0DES, NF2, NCAM1, EPB41L3, RB1, MGMT

Publications for Meninges Hemangiopericytoma

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50PubMed
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Articles related to Meninges Hemangiopericytoma:

(show all 44)
idTitleAuthorsYear
1
Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. (23575898)
2013
2
Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same?: a study of HEY1-NCOA2 fusion. (24124145)
2013
3
Optic nerve meningeal hemangiopericytoma: a clinicopathologic case report. (23294915)
2013
4
Metastasis of intracranial meningeal hemangiopericytoma to thoracic spine 17A years after surgical excision: a case report. (23943153)
2013
5
The role of postoperative radiation therapy in the treatment of meningeal hemangiopericytoma-experience from the SEER database. (22867893)
2013
6
Spinal metastasis from malignant meningeal intracranial hemangiopericytoma: one-staged percutaneous Onyxa8c embolization and resection - a technical innovation. (23845137)
2013
7
Meningeal Hemangiopericytoma with Intracranial Metastases in an HIV-Positive Male: Case Report and Review of the Literature. (22666206)
2012
8
Recurrent meningeal hemangiopericytoma with multiple metastasis and hypoglycemia: a case report. (23024657)
2012
9
Intracranial meningeal hemangiopericytoma metastatic to the scapula. (22229602)
2012
10
Intracranial meningeal hemangiopericytoma: 10A years experience of a tertiary care Institute. (22790838)
2012
11
MRS study of meningeal hemangiopericytoma and edema: a comparison with meningothelial meningioma. (22824994)
2012
12
Phase II study of subcutaneous octreotide in adults with recurrent or progressive meningioma and meningeal hemangiopericytoma. (21558077)
2011
13
The status of MGMT protein expression is a prognostic factor for meningeal hemangiopericytoma: a clinicopathologic and immunohistochemical study of 12 cases at a single institution. (21667225)
2011
14
Response to trabectedin treatment in a highly pretreated patient with an advanced meningeal hemangiopericytoma. (20622667)
2010
15
Meningeal hemangiopericytomas and hemangiopericytoma/solitary fibrous tumors of extracranial soft tissues: a comparison. (20165866)
2010
16
Multiple metastatic progression of meningeal hemangiopericytoma initially diagnosed as atypical meningioma with temporal bone invasion. (19201308)
2009
17
Retinoblastoma (Rb) tumor-suppressor pathway alterations in meningeal hemangiopericytomas: High E2F transcription factor 1 expression and loss of Rb expression: study by double immunofluorescence staining and laser-scanning confocal microscopy. (18459177)
2008
18
Cytomorphologic findings of hemangiopericytoma of the meninges: a case report. (17883098)
2007
19
Meningeal hemangiopericytoma manifesting as massive intracranial hemorrhage--two case reports. (16498220)
2006
20
Bone metastasis of intracranial meningeal hemangiopericytoma. (15990973)
2005
21
Multiple extracranial metastases from a meningeal hemangiopericytoma and severe hypoglycemia: a case report]. (15227844)
2004
22
Meningeal hemangiopericytoma with delayed multiple distant metastases. (15648288)
2004
23
Anaplastic meningioma versus meningeal hemangiopericytoma: immunohistochemical and genetic markers. (15668900)
2004
24
Meningeal hemangiopericytoma metastatic to the adrenal gland with multiple metastases to bones and lungs: a case report. (15143990)
2004
25
Intracranial meningeal hemangiopericytoma: the role of radiotherapy: report of 29 cases and review of the literature. (15042684)
2004
26
Fine needle aspiration cytology of hepatic metastasis from a meningeal hemangiopericytoma. A case report. (12685202)
2003
27
Fetal meningeal hemangiopericytoma. Case report. (12450048)
2002
28
Meningeal hemangiopericytoma: a retrospective study of 21 patients with special review of postoperative external radiotherapy. (11322435)
2001
29
Tc-99m MDP and Tl-201 scintigraphy in a case of metastatic meningeal hemangiopericytoma. (11711721)
2001
30
Prostaglandin D synthase (beta-trace) in meningeal hemangiopericytoma. (11266526)
2001
31
Four cases of meningeal hemangiopericytoma treated with surgery and radiotherapy. (11773263)
2001
32
Clinicopathological features of solitary fibrous tumor of the meninges: An immunohistochemical reappraisal of cases previously diagnosed to be fibrous meningioma or hemangiopericytoma. (11107053)
2000
33
Pancreatic head mass from metastatic meningeal hemangiopericytoma. (18521297)
2000
34
Meningeal hemangiopericytoma in childhood. (11003400)
2000
35
Contribution of immunohistochemistry and electron microscopy for the diagnosis of meningeal hemangiopericytomas. 15 case reports]. (11084416)
2000
36
Hepatic and pulmonary metastases from a meningeal hemangiopericytoma and severe hypoglycemia due to abnormal secretion of insulin-like growth factor: a case report. (10326704)
1999
37
Radiotherapy of bone metastases of a spinal meningeal hemangiopericytoma. (9581183)
1998
38
Management of recurrent meningeal hemangiopericytoma. (9587125)
1998
39
Metastatic meningeal hemangiopericytoma of thoracic spine. (9822848)
1998
40
The immunophenotypic spectrum of meningeal hemangiopericytoma: a comparison with fibrous meningioma and solitary fibrous tumor of meninges. (9351573)
1997
41
Meningeal hemangiopericytoma metastatic to the heart. (8776772)
1996
42
The contribution of cytogenetics to the histogenesis of meningeal hemangiopericytoma. (8858518)
1996
43
Insulin-like growth factor II expression in primary meningeal hemangiopericytoma and its metastasis to the liver accompanied by hypoglycemia. (8760024)
1996
44
Soft-tissue and meningeal hemangiopericytomas: an immunohistochemical and ultrastructural study. (2318483)
1990

Genetic Variations for Meninges Hemangiopericytoma

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Expression for genes affiliated with Meninges Hemangiopericytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meninges Hemangiopericytoma

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Pathways for genes affiliated with Meninges Hemangiopericytoma

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53Reactome, 4Cell Signaling Technology, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Meninges Hemangiopericytoma

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Meninges Hemangiopericytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1dihydrotestosterone44 28 11 2413.3VIM, DES
2s 100449.8MUC1, DES, VIM
3reticulin449.6MUC1, DES, VIM
4b 723449.5VIM, MUC1, DES, CDH1
5mucicarmine449.5VIM, DES, MUC1
6etoposide44 49 59 1112.4VIM, RB1, IGF2, CDH1
7n-(4-hydroxyphenyl)retinamide449.1IGFBP3, RB1, VIM, IGF2
8dexamethasone44 49 28 1112.1IGF2, MGMT, RB1, CDH1
9crcs449.1MUC1, CDH1, MGMT, RB1
10hematoxylin449.1NCAM1, DES, VIM, CDH1, MUC1
11creatinine448.9NCAM1, IGFBP3, PTGDS, CDH1, IGF2
12hyaluronic acid44 249.9MUC1, IGFBP3, CDH1, VIM, DES
13sodium bisulfite448.8CDH1, IGF2, MGMT
14p002448.8RB1, DES, IGF2, MGMT, CDH1
15progestin448.7VIM, DES, IGF2, IGFBP3, MUC1, CDH1
16matrigel448.7RB1, VIM, MUC1, CDH1, NCAM1
17formaldehyde44 249.6CDH1, MUC1, DES, RB1, MGMT, VIM
18bromodeoxyuridine448.5VIM, E2F1, RB1, DES, NCAM1
19paclitaxel44 49 1110.4CDH1, RB1, E2F1, IGFBP3, IGF2
20azathioprine44 49 2 1111.4IGFBP3, CDH1, IGF2, DES, MGMT, VIM
21adriamycin448.4MUC1, CDH1, RB1, E2F1, DES, VIM
22folate448.3MUC1, CDH1, IGFBP3, IGF2, VIM, MGMT
23heparin44 28 11 2411.3VIM, DES, NCAM1, IGF2, IGFBP3, CDH1
24tgf beta1448.3CDH1, IGFBP3, IGF2, E2F1, VIM
25actinomycin d448.3DES, VIM, IGF2, MUC1, RB1, E2F1
26retinoid448.3PTGDS, CDH1, IGFBP3, E2F1, VIM
27thymidylate448.2MGMT, CDH1, VIM, RB1, E2F1
28rapamycin448.2CDH1, IGF2, VIM, NF2, RB1, E2F1
29vincristine44 49 1110.2E2F1, NCAM1, RB1, MGMT, VIM
305-aza-2deoxycytidine448.1IGFBP3, MGMT, IGF2, CDH1, EPB41L3, VIM
31tamoxifen44 49 28 1111.1VIM, MUC1, IGF2, IGFBP3, CDH1, E2F1
32agar448.0CDH1, MUC1, IGF2, E2F1, NF2, RB1
33cyclic amp44 249.0RB1, MUC1, CDH1, E2F1, VIM, DES
34paraffin447.9IGF2, CDH1, VIM, MGMT, MUC1, NCAM1
35estradiol44 11 249.9MUC1, RB1, E2F1, VIM, DES, IGF2
36chloramphenicol44 2 119.9E2F1, MUC1, IGFBP3, IGF2, MGMT, VIM
37lactate447.9CDH1, VIM, IGFBP3, MGMT, DES, NCAM1
385fluorouracil447.5MUC1, CDH1, IGFBP3, IGF2, RB1, MGMT
39methotrexate44 49 119.5E2F1, CDH1, IGFBP3, MUC1, RB1, VIM
40cisplatin44 49 59 1110.5IGF2, MGMT, RB1, IGFBP3, MUC1, CDH1
4112-o-tetradecanoylphorbol 13-acetate447.3E2F1, VIM, DES, CDH1, MUC1, NCAM1
42tyrosine447.2RB1, CDH1, E2F1, IGF2, NF2, NCAM1
43thymidine44 248.1IGFBP3, MUC1, EPB41L3, IGF2, DES, RB1
44doxorubicin44 49 119.1IGFBP3, CDH1, VIM, NCAM1, DES, RB1
45cysteine447.0CDH1, MUC1, IGFBP3, VIM, IGF2, NCAM1
46testosterone44 59 11 249.9NCAM1, IGF2, RB1, PTGDS, CDH1, MUC1
47serine446.8CDH1, MUC1, IGFBP3, IGF2, NF2, NCAM1
48vegf446.5IGFBP3, MGMT, DES, IGF2, E2F1, VIM
49retinoic acid44 247.2RB1, IGFBP3, MGMT, NCAM1, DES, MUC1
50progesterone44 59 28 11 249.7VIM, EPB41L3, CDH1, MUC1, IGFBP3, DES

GO Terms for genes affiliated with Meninges Hemangiopericytoma

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16Gene Ontology
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Cellular components related to Meninges Hemangiopericytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Rb-E2F complexGO:0351899.3RB1, E2F1

Biological processes related to Meninges Hemangiopericytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-cell adhesionGO:0224089.8CDH1, NF2
2negative regulation of transcription involved in G1/S transition of mitotic cell cycleGO:0719309.2RB1, E2F1
3regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432819.1CDH1, MGMT

Molecular functions related to Meninges Hemangiopericytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.2EPB41L3, DES, VIM
2identical protein bindingGO:0428029.0NCAM1, DES, RB1, VIM
3protein bindingGO:0055156.0VIM, E2F1, RB1, DES, NF2, IGF2

Products for genes affiliated with Meninges Hemangiopericytoma

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Sources for Meninges Hemangiopericytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet