MCID: MNN006
MIFTS: 33

Meninges Hemangiopericytoma malady

Summaries for Meninges Hemangiopericytoma

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33MalaCards
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MalaCards: Meninges Hemangiopericytoma, also known as hemangiopericytoma of meninges, is related to hypoglycemia and fibrous meningioma. An important gene associated with Meninges Hemangiopericytoma is PTGDS (prostaglandin D2 synthase 21kDa (brain)), and among its related pathways are Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Adhesion. The compounds dihydrotestosterone and s 100 have been mentioned in the context of this disorder. Related mouse phenotypes are embryogenesis and reproductive system.

Aliases & Classifications for Meninges Hemangiopericytoma

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

meninges hemangiopericytoma 8
hemangiopericytoma of meninges 8 61
meningeal hemangiopericytoma 8


External Ids:

Disease Ontology8 DOID:4957
SNOMED-CT57 277522009
NCIt40 C4660

Related Diseases for Meninges Hemangiopericytoma

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17GeneCards, 18GeneDecks
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Diseases related to Meninges Hemangiopericytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia30.6IGFBP3, IGF2
2fibrous meningioma30.1NF2, MUC1
3solitary fibrous tumor10.3
4meningothelial meningioma10.1
5neurilemmoma10.0NF2
6hemangioblastoma10.0MUC1
7myeloid leukemia10.0E2F1
8alzheimer's disease10.0PTGDS
9benign mesothelioma10.0NF2
10syringoma10.0MUC1
11infantile myofibromatosis10.0DES
12sertoli-leydig cell tumor10.0MUC1
13seminoma10.0IGF2
14lymphangioleiomyomatosis10.0DES
15infertility10.0PTGDS
16lipoma10.0DES
17adenomatoid tumor10.0VIM
18hepatitis b10.0E2F1
19cataract10.0NF2
20ductal carcinoma in situ10.0CDH1
21kidney cancer10.0CDH1
22esophageal cancer10.0CDH1
23macular holes10.0PTGDS
24anaplastic ependymoma10.0NF2, MUC1
25multiple endocrine neoplasia10.0NF2
26multiple myeloma10.0NCAM1
27neuroblastoma10.0NCAM1
28angiomyolipoma10.0DES, VIM
29germ cell cancer10.0NCAM1
30perineurioma10.0MUC1, VIM
31hidradenoma10.0MUC1
32fibromatosis10.0DES, VIM
33desmoplastic small round cell tumor10.0MUC1, DES
34schizophrenia10.0PTGDS
35glomus tumor10.0DES, VIM
36benign meningioma10.0EPB41L3, NF2
37secretory meningioma10.0MUC1, VIM
38epithelioid leiomyosarcoma10.0DES, VIM
39pseudosarcomatous fibromatosis10.0VIM, DES
40retinoblastoma10.0RB1, E2F1
41clear cell ependymoma10.0MUC1, VIM
42papilloma10.0RB1, E2F1
43choroid plexus papilloma10.0MUC1, IGF2
44alveolar soft part sarcoma10.0VIM, DES
45pheochromocytoma10.0NCAM1
46paraganglioma10.0NCAM1
47angiosarcoma10.0MUC1, VIM
48dedifferentiated liposarcoma10.0RB1, DES
49fibrous histiocytoma10.0VIM, DES
50liver cirrhosis10.0IGFBP3

Graphical network of the top 20 diseases related to Meninges Hemangiopericytoma:



Diseases related to meninges hemangiopericytoma

Clinical Features for Meninges Hemangiopericytoma

Drugs & Therapeutics for Meninges Hemangiopericytoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Meninges Hemangiopericytoma

Drug clinical trials:

Search ClinicalTrials for Meninges Hemangiopericytoma

Search NIH Clinical Center for Meninges Hemangiopericytoma

Search CenterWatch for Meninges Hemangiopericytoma

Genetic Tests for Meninges Hemangiopericytoma

Anatomical Context for Meninges Hemangiopericytoma

Animal Models for Meninges Hemangiopericytoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Meninges Hemangiopericytoma

Sources:
51PubMed
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Articles related to Meninges Hemangiopericytoma:

idTitleAuthorsYear
1
Cytomorphologic findings of hemangiopericytoma of the meninges: a case report. (17883098)
2007
2
Clinicopathological features of solitary fibrous tumor of the meninges: An immunohistochemical reappraisal of cases previously diagnosed to be fibrous meningioma or hemangiopericytoma. (11107053)
2000
3
The immunophenotypic spectrum of meningeal hemangiopericytoma: a comparison with fibrous meningioma and solitary fibrous tumor of meninges. (9351573)
1997

Genetic Variations for Meninges Hemangiopericytoma

Expression for genes affiliated with Meninges Hemangiopericytoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meninges Hemangiopericytoma

Search GEO for disease gene expression data for Meninges Hemangiopericytoma.

Pathways for genes affiliated with Meninges Hemangiopericytoma

Sources:
54Reactome, 4Cell Signaling Technology, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Meninges Hemangiopericytoma

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Meninges Hemangiopericytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1dihydrotestosterone45 29 11 2413.3DES, VIM
2s 100459.8DES, VIM, MUC1
3reticulin459.6VIM, DES, MUC1
4b 723459.5MUC1, DES, VIM, CDH1
5mucicarmine459.5VIM, DES, MUC1
6etoposide45 50 60 1112.4RB1, IGF2, CDH1, VIM
7biotin45 11 2411.2RB1, DES, MUC1, VIM
8n-(4-hydroxyphenyl)retinamide459.1VIM, IGF2, RB1, IGFBP3
9dexamethasone45 50 29 1112.1CDH1, MGMT, RB1, IGF2
10crcs459.1RB1, MUC1, MGMT, CDH1
11hematoxylin459.1VIM, DES, NCAM1, MUC1, CDH1
12creatinine458.9IGF2, CDH1, PTGDS, NCAM1, IGFBP3
13hyaluronic acid45 249.9DES, IGFBP3, MUC1, VIM, CDH1
14sodium bisulfite458.8MGMT, IGF2, CDH1
15p002458.8CDH1, IGF2, DES, RB1, MGMT
16progestin458.7CDH1, DES, MUC1, IGFBP3, IGF2, VIM
17matrigel458.7NCAM1, CDH1, RB1, VIM, MUC1
18formaldehyde45 249.6CDH1, MUC1, DES, RB1, MGMT, VIM
19bromodeoxyuridine458.5E2F1, RB1, VIM, DES, NCAM1
20paclitaxel45 50 1110.4E2F1, RB1, CDH1, IGFBP3, IGF2
21azathioprine45 50 2 1111.4VIM, MGMT, DES, IGF2, IGFBP3, CDH1
22adriamycin458.4DES, CDH1, RB1, VIM, E2F1, MUC1
23folate458.3VIM, CDH1, MUC1, IGFBP3, IGF2, MGMT
24heparin45 29 11 2411.3DES, CDH1, IGFBP3, IGF2, NCAM1, VIM
25tgf beta1458.3IGFBP3, CDH1, IGF2, E2F1, VIM
26actinomycin d458.3DES, VIM, IGF2, E2F1, RB1, MUC1
27retinoid458.3PTGDS, CDH1, E2F1, VIM, IGFBP3
28thymidylate458.2CDH1, E2F1, MGMT, RB1, VIM
29rapamycin458.2E2F1, RB1, VIM, IGF2, CDH1, NF2
30vincristine45 50 1110.2VIM, E2F1, MGMT, RB1, NCAM1
315-aza-2deoxycytidine458.1VIM, MGMT, IGFBP3, CDH1, EPB41L3, IGF2
32tamoxifen45 50 29 1111.1VIM, E2F1, CDH1, MUC1, IGF2, IGFBP3
33agar458.0RB1, E2F1, VIM, CDH1, IGF2, MUC1
34cyclic amp45 249.0MUC1, DES, RB1, E2F1, VIM, CDH1
35paraffin457.9IGF2, VIM, DES, NCAM1, NF2, MGMT
36estradiol45 11 249.9IGFBP3, IGF2, DES, RB1, E2F1, VIM
37chloramphenicol45 2 119.9MUC1, IGFBP3, IGF2, MGMT, E2F1, VIM
38lactate457.9VIM, CDH1, IGFBP3, IGF2, NCAM1, DES
395fluorouracil457.5E2F1, MGMT, RB1, CDH1, MUC1, IGFBP3
40methotrexate45 50 119.5VIM, MUC1, E2F1, MGMT, RB1, IGFBP3
41cisplatin45 50 60 1110.5MGMT, E2F1, RB1, IGF2, IGFBP3, MUC1
4212-o-tetradecanoylphorbol 13-acetate457.3DES, RB1, NCAM1, MUC1, CDH1, VIM
43thymidine45 248.1MUC1, IGF2, DES, IGFBP3, EPB41L3, RB1
44doxorubicin45 50 119.1MGMT, E2F1, IGFBP3, RB1, DES, VIM
45cysteine457.0VIM, NF2, IGF2, CDH1, MUC1, NCAM1
46testosterone45 60 11 249.9E2F1, RB1, DES, NCAM1, IGF2, IGFBP3
47serine456.8IGF2, IGFBP3, DES, MUC1, CDH1, RB1
48vegf456.5VIM, CDH1, MUC1, IGFBP3, IGF2, NCAM1
49retinoic acid45 247.2PTGDS, VIM, CDH1, MUC1, IGFBP3, IGF2
50progesterone45 60 29 11 249.7NCAM1, VIM, MGMT, RB1, DES, NF2

GO Terms for genes affiliated with Meninges Hemangiopericytoma

Sources:
16Gene Ontology
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Cellular components related to Meninges Hemangiopericytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Rb-E2F complexGO:0351899.3RB1, E2F1

Biological processes related to Meninges Hemangiopericytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-cell adhesionGO:0224089.8CDH1, NF2
2negative regulation of transcription involved in G1/S transition of mitotic cell cycleGO:0719309.2RB1, E2F1
3regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432819.1CDH1, MGMT

Molecular functions related to Meninges Hemangiopericytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.2EPB41L3, DES, VIM
2identical protein bindingGO:0428029.0NCAM1, DES, RB1, VIM
3protein bindingGO:0055156.0VIM, E2F1, RB1, DES, NF2, IGF2

Products for genes affiliated with Meninges Hemangiopericytoma

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  • Antibodies

Sources for Meninges Hemangiopericytoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet