Meninges Hemangiopericytoma malady

MalaCards: Meninges Hemangiopericytoma, also known as hemangiopericytoma of meninges (disorder), is related to hypoglycemia and fibrous meningioma. An important gene associated with Meninges Hemangiopericytoma is PTGDS (prostaglandin D2 synthase 21kDa (brain)), and among its related pathways are Adhesion and MNAR-PELP1 and Estrogen Receptor Interaction. The compounds vincristine and etoposide have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Aliases & Descriptions:

meninges hemangiopericytoma 6 hemangiopericytoma of meninges (disorder) 6 hemangiopericytoma of meninges 43

meningeal hemangiopericytoma 6 hemangiopericytoma 43

Diseases related to meninges hemangiopericytoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 331)

id	Related Disease	Score	Top Affiliating Genes
1	hypoglycemia	29.7	VIM, IGF2, IGFBP3, DES
2	fibrous meningioma	29.6	MUC1, NF2, DES
3	glomus tumor	28.0	VIM, MUC1, DES
4	meningitis	27.5	NCAM1, RB1, VIM, MUC1, CDH1, IGF2
5	hemangiopericytoma	27.5	NCAM1, RB1, VIM, MUC1, CDH1, IGF2
6	hemangioblastoma	27.3	NCAM1, VIM, MUC1, DES
7	anaplastic meningioma	26.6	RB1, VIM, MUC1, CDH1, NF2, EPB41L3
8	angiosarcoma	26.6	VIM, MUC1, DES
9	meningioma	25.8	NCAM1, RB1, VIM, MUC1, CDH1, IGF2
10	retinoblastoma	25.8	NCAM1, RB1, VIM, MUC1, CDH1, IGF2
11	liposarcoma	25.7	RB1, VIM, MUC1, DES
12	spindle cell thymoma	13.3	MUC1, DES
13	desmoplastic small round cell tumor	13.3	MUC1, DES
14	insulin-like growth factor 1 resistance to	13.2	IGF2, IGFBP3
15	anaplastic ependymoma	13.2	MUC1, NF2
16	choroid plexus papilloma	13.2	MUC1, IGF2
17	laron syndrome	13.1	IGF2, IGFBP3
18	acid-labile subunit	13.1	IGF2, IGFBP3
19	neurofibromatosis	13.1	NF2, EPB41L3
20	growth disorders	13.0	IGF2, IGFBP3
21	lobular neoplasia	12.9	MUC1, CDH1
22	alveolar rhabdomyosarcoma	12.9	RB1, DES
23	lymph node palisaded myofibroblastoma	12.9	VIM, DES
24	myxosarcoma	12.9	VIM, DES
25	infantile digital fibromatosis	12.9	VIM, DES
26	prostate leiomyoma	12.9	VIM, DES
27	glomangiomyoma	12.9	VIM, DES
28	infantile myofibromatosis	12.9	VIM, DES
29	meninges sarcoma	12.9	VIM, DES
30	myofibroma	12.9	VIM, DES
31	congenital epulis	12.9	VIM, DES
32	endometrial stromal nodule	12.9	VIM, DES
33	arachnoiditis	12.9	NCAM1, PTGDS, NF2
34	pseudosarcomatous fibromatosis	12.9	VIM, DES
35	epithelioid leiomyosarcoma	12.9	VIM, DES
36	epulis	12.9	VIM, DES
37	orbit rhabdomyosarcoma	12.9	VIM, DES
38	endometrial stromal tumor	12.9	VIM, DES
39	proliferative diabetic retinopathy	12.9	IGF2, IGFBP3, PTGDS
40	alveolar soft part sarcoma	12.9	VIM, DES
41	rhabdoid cancer	12.9	VIM, DES
42	ossifying fibromyxoid tumor	12.9	VIM, DES
43	spindle cell lipoma	12.9	VIM, DES
44	carotid artery dissection	12.9	VIM, DES
45	choledochal cyst	12.9	VIM, DES
46	benign metastasizing leiomyoma	12.9	VIM, DES
47	cutaneous fibrous histiocytoma	12.9	VIM, DES
48	costello syndrome	12.8	IGF2, IGFBP3
49	cellular schwannoma	12.8	VIM, NF2
50	merkel cell carcinoma	12.8	NCAM1, MUC1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to meninges hemangiopericytoma:

²²

MGI Mouse Phenotypes related to meninges hemangiopericytoma:

²⁵ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	10.2	NF2
2	endocrine/exocrine gland phenotype	MP:0005379	10.1	NF2, EPB41L3
3	immune system phenotype	MP:0005387	8.9	VIM, PTGDS, NF2, E2F1
4	tumorigenesis	MP:0002006	8.1	RB1, EPB41L3, E2F1, NF2, PTGDS, CDH1
5	mortality/aging	MP:0010768	8.0	EPB41L3, DES, NF2, PTGDS, CDH1, RB1
6	muscle phenotype	MP:0005369	7.6	E2F1, DES, IGFBP3, IGF2, VIM, RB1
7	integument phenotype	MP:0010771	7.5	E2F1, PTGDS, IGF2, CDH1, MUC1, RB1
8	vision/eye phenotype	MP:0005391	7.4	E2F1, NF2, IGF2, MUC1, VIM, RB1
9	behavior/neurological phenotype	MP:0005386	7.4	EPB41L3, E2F1, DES, PTGDS, IGF2, VIM
10	reproductive system phenotype	MP:0005389	7.1	EPB41L3, E2F1, NF2, IGF2, CDH1, MUC1
11	homeostasis/metabolism phenotype	MP:0005376	6.3	E2F1, DES, NF2, IGFBP3, IGF2, CDH1

Articles related to meninges hemangiopericytoma:

id	Title	Authors	Year	Affiliating Genes
1	Retinoblastoma (Rb) tumor-suppressor pathway alterations in meningeal hemangiopericytomas: High E2F transcription factor 1 expression and loss of Rb expression: study by double immunofluorescence staining and laser-scanning confocal microscopy. (18459177)	Martinez J.C.... Ricoy J.R.	2008	RB1, E2F1
2	Multiple extracranial metastases from a meningeal hemangiopericytoma and severe hypoglycemia: a case report (15227844)	Miyamoto S.... Itabashi M.	2004	IGF2
3	Anaplastic meningioma versus meningeal hemangiopericytoma: immunohistochemical and genetic markers. (15668900)	Rajaram V.... Perry A.	2004	NF2, EPB41L3
4	Prostaglandin D synthase (beta-trace) in meningeal hemangiopericytoma. (11266526)	Kawashima M.... Iwaki T.	2001	PTGDS
5	Contribution of immunohistochemistry and electron microscopy for the diagnosis of meningeal hemangiopericytomas. 15 case reports (11084416)	Bouvier-Labit C.... Figarella-Branger D.	2000	CDH1, VIM, NCAM1
6	The immunophenotypic spectrum of meningeal hemangiopericytoma: a comparison with fibrous meningioma and solitary fibrous tumor of meninges. (9351573)	Perry A.... Nascimento A.G.	1997	DES
7	Insulin-like growth factor II expression in primary meningeal hemangiopericytoma and its metastasis to the liver accompanied by hypoglycemia. (8760024)	Sohda T.... Yun K.	1996	IGF2, IGFBP3
8	Soft-tissue and meningeal hemangiopericytomas: an immunohistochemical and ultrastructural study. (2318483)	d'Amore E.S.... Sung J.H.	1990	VIM, DES, MUC1

Genes related to meninges hemangiopericytoma according to GeneCards:

(show all 12)

id	Symbol	Description	Score	GeneCards Section Context
1	PTGDS	prostaglandin D2 synthase 21kDa (brain)	11.0	Publications
2	NF2	neurofibromin 2 (merlin)	11.0	Publications
3	EPB41L3	erythrocyte membrane protein band 4.1-like 3	11.0	Publications
4	E2F1	E2F transcription factor 1	11.0	Publications
5	DES	desmin	11.0	Publications
6	RB1	retinoblastoma 1	11.0	Publications
7	VIM	vimentin	11.0	Publications
8	NCAM1	neural cell adhesion molecule 1	11.0	Publications
9	MUC1	mucin 1, cell surface associated	11.0	Publications
10	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
11	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
12	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications

Pathways related to meninges hemangiopericytoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Adhesion3	10.1	NCAM1
2	MNAR-PELP1 and Estrogen Receptor Interaction36	9.8	RB1, E2F1
3	Inhibition of Ribosome Biogenesis by p14(ARF)36	9.5	RB1, E2F1
4	Bladder cancer20	9.4	E2F1, CDH1, RB1
5	Melanoma20	9.3	RB1, CDH1, E2F1
6	Cytoskeletal Signaling3	9.0	VIM, CDH1, NF2, DES
7	Glioblastoma Multiforme36	8.9	RB1, IGF2, NF2, E2F1
8	ILK Signaling36	8.1	IGF2, CDH1, MUC1, VIM

Compounds related to meninges hemangiopericytoma according to GeneDecks:

(show top 50)    (show all 103)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	12.7	NCAM1
2	etoposide32 42 9 9	12.6	E2F1, CDH1, RB1
3	s 10032	9.5	VIM, MUC1, DES
4	reticulin32	9.3	MUC1, DES, VIM
5	mucicarmine32	9.3	VIM, MUC1, DES
6	12-o-tetradecanoylphorbol 13-acetate32	9.2	NCAM1, CDH1, E2F1, RB1
7	b 72332	9.1	DES, MUC1, VIM, CDH1
8	bromodeoxyuridine32	8.9	DES, RB1, NCAM1, E2F1, VIM
9	estradiol32 9 18 9	11.9	RB1, E2F1, DES, MUC1, VIM
10	thymidylate32	8.8	CDH1, RB1, VIM, E2F1
11	progesterone32 42 9 18 9	12.8	NF2, E2F1, EPB41L3, DES, RB1, NCAM1
12	biotin32 9 18 9	11.8	VIM, DES, RB1, MUC1
13	progestin32	8.8	VIM, DES, CDH1, IGF2
14	dihydrotestosterone32 9 18 9	11.7	DES, IGFBP3, IGF2, VIM
15	formaldehyde32 18	9.6	DES, CDH1, RB1, MUC1, VIM
16	rapamycin32 42	9.6	E2F1, RB1, VIM, IGF2, NF2
17	hematoxylin32	8.6	CDH1, MUC1, DES, VIM, NCAM1
18	n-(4-hydroxyphenyl)retinamide32	8.6	VIM, RB1, IGFBP3, IGF2
19	retinoid32	8.5	IGFBP3, PTGDS, E2F1, VIM, CDH1
20	adriamycin32	8.4	VIM, CDH1, E2F1, DES, RB1, MUC1
21	hyaluronic acid32 18	9.4	MUC1, VIM, CDH1, IGFBP3, DES
22	matrigel32	8.4	CDH1, VIM, RB1, NCAM1, MUC1
23	estrogen32	8.3	IGF2, IGFBP3, DES, E2F1, CDH1
24	azathioprine32 34 9 9	11.1	VIM, CDH1, DES, IGFBP3, IGF2
25	cyclic amp32 18	9.1	DES, RB1, VIM, E2F1, MUC1, CDH1
26	tgf beta132	8.1	CDH1, E2F1, IGFBP3, IGF2, VIM
27	cysteine32	8.1	CDH1, NF2, IGFBP3, IGF2, MUC1
28	methotrexate32 34 42 9 9	12.1	E2F1, RB1, VIM, MUC1, CDH1, IGFBP3
29	5-aza-2deoxycytidine32	8.1	VIM, CDH1, IGF2, IGFBP3, EPB41L3
30	retinoic acid32 42 18	10.1	E2F1, PTGDS, IGFBP3, IGF2, RB1, NCAM1
31	actinomycin d32	8.0	RB1, VIM, MUC1, E2F1, DES, IGF2
32	chloramphenicol32 9 9	10.0	IGF2, VIM, MUC1, IGFBP3, E2F1
33	histamine32 18	8.9	VIM, PTGDS, CDH1, IGF2, NCAM1
34	folate32	7.9	VIM, CDH1, IGFBP3, MUC1, IGF2
35	doxorubicin32 34 9 9	10.8	E2F1, RB1, DES, CDH1, IGFBP3, VIM
36	paclitaxel32 34 9 9	10.8	E2F1, IGFBP3, IGF2, CDH1, RB1, VIM
37	5fluorouracil32	7.7	RB1, CDH1, MUC1, IGF2, E2F1, IGFBP3
38	agar32	7.7	MUC1, RB1, VIM, E2F1, NF2, IGF2
39	tamoxifen32 34 9 9	10.6	E2F1, IGF2, CDH1, MUC1, IGFBP3, VIM
40	cisplatin32 34 9 9	10.6	CDH1, MUC1, E2F1, IGFBP3, IGF2, RB1
41	thymidine32 18	8.6	MUC1, IGFBP3, E2F1, DES, RB1, EPB41L3
42	lactate32	7.6	NCAM1, VIM, CDH1, IGF2, DES, IGFBP3
43	heparin32 9 18 9	10.5	DES, CDH1, VIM, NCAM1, IGF2, IGFBP3
44	butyrate32	7.3	RB1, VIM, MUC1, CDH1, IGF2, IGFBP3
45	paraffin32	7.2	NCAM1, NF2, CDH1, MUC1, VIM, RB1
46	dexamethasone32 42 34 9 9	11.1	RB1, IGF2, CDH1, MUC1, VIM, NCAM1
47	creatinine32	6.9	IGF2, PTGDS, IGFBP3, VIM, CDH1, MUC1
48	vegf32	6.5	E2F1, IGF2, CDH1, MUC1, VIM, RB1
49	testosterone32 9 18 9	9.3	NCAM1, RB1, VIM, MUC1, CDH1, IGF2
50	serine32	6.2	IGF2, IGFBP3, NF2, DES, CDH1, MUC1

Cellular components related to meninges hemangiopericytoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Rb-E2F complex	GO:035189	9.8	RB1, E2F1

Biological processes related to meninges hemangiopericytoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell-cell adhesion	GO:022408	9.7	CDH1, NF2
2	negative regulation of transcription involved in G1/S phase of mitotic cell cycle	GO:071930	9.5	RB1, E2F1

Molecular functions related to meninges hemangiopericytoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	core promoter binding	GO:001047	9.8	RB1, E2F1
2	protein binding	GO:005515	5.7	RB1, EPB41L3, E2F1, DES, NF2, IGFBP3