MCID: MNN012
MIFTS: 78

Meningioma malady

Genetic diseases, Rare diseases, Neuronal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Meningioma

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9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Meningiomas are benign, slow-growing tumors, classified as brain tumors, but actually growing in the three protective membranes that surround the brain (meninges). sometimes they cause thickening or thinning of adjoining skull bones. meningiomas do not spread to other areas of the body. signs and symptoms vary according to the size and location of the tumor. the exact cause of this condition is unknown. last updated: 7/20/2011

MalaCards: Meningioma, also known as intracranial meningioma, is related to spinal meningioma and benign meningioma. An important gene associated with Meningioma is MN1 (meningioma (disrupted in balanced translocation) 1), and among its related pathways are Nuclear signaling by ERBB4 and Glioblastoma Multiforme. The drugs mifepristone and cytarabine and the compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related mouse phenotypes are tumorigenesis and vision/eye.

Disease Ontology:9 A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid "cap" cells of the arachnoid villi in the meninges.

Wikipedia:66 Meningiomas are a diverse set of tumors arising from the meninges, the membranous layers surrounding the... more...

Description from OMIM:48 606190,607174

Aliases & Classifications for Meningioma

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9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 37MESH via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50
meningioma:
Prevalence: 1-9/100000; Age of onset: Variable
familial multiple meningioma:
Inheritance: Autosomal dominant; Age of onset: Variable


Aliases & Descriptions:

meningioma 9 10 44 48 11 46 50 63
intracranial meningioma 9 46 63
supratentorial meningioma 9 63
meningioma, benign, no icd-o subtype 9
meningothelial cell neoplasm 63
familial multiple meningioma 50
meningothelial cell tumor 9
neoplasm of the meninges 9
primary meningeal tumor 9
neoplasm of meninges 9
meningeal neoplasms 63
meningeal neoplasm 9
meningioma nos 9
meningiomas 9


External Ids:

Disease Ontology9 DOID:3565
MeSH36 D008577
NCIt41 C3229
ICD10 via Orphanet27 D32.9
SNOMED-CT via Orphanet60 19453003
UMLS via Orphanet64 C0025286
MESH via Orphanet37 D008579

Related Diseases for Meningioma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Meningioma family:

Benign Meningioma Familial Meningioma
Meningioma, Sis-Related

Diseases related to Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 470)
idRelated DiseaseScoreTop Affiliating Genes
1spinal meningioma31.4SMARCE1, NF2
2benign meningioma31.1MKI67, PGR, ETS1, NF2, EGFL6
3secretory meningioma31.0VIM, MUC1
4rhabdoid meningioma31.0GFAP, VIM
5cerebral meningioma30.9EGF, PGR
6fibrous meningioma30.8MUC1, S100B, NF2, EGFL6
7hemangiopericytoma30.7S100B, MUC1, VIM
8astrocytoma30.7MKI67, GFAP, PTEN, VIM, ETS1, PDGFB
9transitional meningioma30.6NF2, MUC1
10ependymoma30.6NF2, S100B, MUC1, VIM, GFAP, MKI67
11familial meningioma30.6SMARCE1, SUFU
12medulloblastoma30.5SMARCB1, GFAP, SUFU, PDGFB, S100B
13adenocarcinoma30.5MKI67, PTEN, PGR, VIM, MUC1, ETS1
14hemangioblastoma30.4S100B, MUC1, GFAP
15breast cancer30.4MKI67, PTEN, PGR, MUC1, ETS1, NF2
16glioblastoma multiforme30.4GFAP, PTEN, PDGFB, EGF
17neurilemmoma30.3SMARCB1, GFAP, NF2
18fibrous histiocytoma30.3VIM, S100B
19retinoblastoma30.3MKI67, SMARCB1, GFAP, EGF
20choroid plexus papilloma30.2GFAP, MUC1, S100B
21neurofibroma30.2VIM, MUC1, S100B, NF2
22chordoma30.2GFAP, VIM, MUC1, S100B
23ischemia30.2GFAP, ETS1, PDGFB, NF2
24sarcoma30.2MKI67, SMARCB1, VIM, MUC1, ETS1, PDGFB
25pilocytic astrocytoma30.1GFAP, PTEN, S100B
26anaplastic astrocytoma30.1MKI67, GFAP, PTEN
27melanoma30.1MKI67, PTEN, VIM, ETS1, PDGFB, S100B
28perineurioma30.1VIM, MUC1, S100B
29papillary carcinoma30.1ETS1, MUC1, PGR, MKI67
30ganglioglioma30.0GFAP, S100B
31oligodendroglioma30.0PTEN, GFAP
32thyroid cancer30.0PTEN, ETS1, EGF
33gliosarcoma30.0GFAP, PTEN
34dermatofibrosarcoma29.9PDGFB
35langerhans-cell histiocytosis29.9PDGFB, S100B
36myxopapillary ependymoma29.9GFAP, S100B
37chondrosarcoma29.9VIM, MUC1, S100B
38dermatofibrosarcoma protuberans29.9S100B, PDGFB, MUC1, VIM
39gastrointestinal stromal tumor29.9MKI67, VIM, S100B, NF2
40adenoid cystic carcinoma29.9MKI67, VIM, MUC1, S100B
41rhabdoid tumor29.9SMARCB1, VIM, MUC1
42retinal detachment29.8GFAP, PDGFB
43giant cell glioblastoma29.8GFAP, PTEN
44tuberous sclerosis29.8GFAP, PTEN, VIM, S100B
45anaplastic ependymoma29.8GFAP, PTEN, MUC1, S100B, NF2
46malignant glioma29.8GFAP, PTEN, PDGFB, NF2, EGF
47optic nerve sheath meningioma10.7
48clear cell meningioma10.7
49chordoid meningioma10.7
50parasagittal meningioma10.6

Graphical network of the top 20 diseases related to Meningioma:



Diseases related to meningioma

Symptoms for Meningioma

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48OMIM
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Symptoms by clinical synopsis from OMIM:

607174

Clinical features from OMIM:

606190,607174

Drugs & Therapeutics for Meningioma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Meningioma

Drug clinical trials:

Search ClinicalTrials for Meningioma

Search NIH Clinical Center for Meningioma

Search CenterWatch for Meningioma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Meningioma

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Anatomical Context for Meningioma

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34MalaCards
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MalaCards organs/tissues related to Meningioma:

34
Brain, Bone, Spinal cord, Pituitary, Endothelial, Lung, Breast, Pineal, Thyroid, Prostate, Liver, Lymph node, B cells, Temporal lobe, Myeloid, Skin, T cells, Eye, Colon, Tongue, Cortex, Ovary, Testis, Testes, Bone marrow, Thymus, Monocytes, Heart, Placenta, Olfactory bulb

Animal Models for Meningioma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Meningioma:

38 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.3SMARCB1, MN1, PTEN, SUFU, PGR, MUC1
2MP:000539110.2SMARCB1, GFAP, PTEN, VIM, MUC1, PDGFB
3MP:001077110.2PTEN, SUFU, PGR, MUC1, PDGFB, S100B
4MP:000538010.2SMARCB1, PTEN, SUFU, PGR, VIM, ETS1
5MP:000538110.1SMARCB1, GFAP, MN1, PTEN, SUFU, MUC1
6MP:000538910.1PTEN, PGR, VIM, PDGFB, NF2, EGF
7MP:000287310.1GFAP, PTEN, SUFU, PGR, MUC1, S100B
8MP:000538710.1EGF, THOC5, SMARCB1, SMARCE1, GFAP, PTEN
9MP:000537610.0SMARCB1, GFAP, MN1, PTEN, SUFU, PGR
10MP:000537010.0THOC5, SMARCB1, PTEN, MUC1, PDGFB, NF2
11MP:001076810.0MN1, GFAP, SMARCE1, SMARCB1, THOC5, PTEN
12MP:000538510.0SMARCB1, GFAP, PTEN, SUFU, PGR, VIM
13MP:00053789.6SMARCB1, GFAP, PTEN, SUFU, VIM, ETS1

Publications for Meningioma

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53PubMed
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Articles related to Meningioma:

(show top 50)    (show all 2103)
idTitleAuthorsYear
1
Brain tissue adaptability to slow-growing tumors: case report of clivus meningioma. (24308252)
2013
2
A proposed scheme for the classification and surgical planning of falcine meningioma treatment. (23047062)
2012
3
Primary meningioma of the middle turbinate: a case report. (23076856)
2012
4
Mature posterior fossa teratoma mimicking infratentorial meningioma: a case report. (22030172)
2012
5
Analysis of the role of hMLH1 hypermethylation and microsatellite instability in meningioma progression. (22930430)
2012
6
Suprasellar meningioma presenting with an altitudinal field defect. (21873066)
2012
7
Transient global amnesia as a revealing sign of giant transtentorial meningioma: case report and review of the literature. (21629022)
2011
8
I+3I^1 integrin promotes radiation-induced migration of meningioma cells. (21455571)
2011
9
Meningial perineurioma: a benign peripheral nerve sheath tumor in a previously unrecognized central nervous system location, mimicking meningioma. (21831532)
2011
10
Rhabdoid meningioma presenting with subependymal and diffuse meningeal involvement but no mass lesion. (20800496)
2010
11
Rhabdoid meningioma: rapid intraoperative diagnosis on squash smears. (19941363)
2010
12
Hemangiopericytoma: collision with meningioma and recurrence. (20198500)
2010
13
SMARCB1 mutations are not a common cause of multiple meningiomas. (20472658)
2010
14
NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth. (19451225)
2009
15
Metastasis of breast carcinoma to spinal meningioma. (19671116)
2009
16
Normal pressure hydrocephalus after radiosurgery for sphenoid ridge meningioma. (19013812)
2009
17
The microglial/macrophagic response at the tumour-brain border of invasive meningiomas. (19187060)
2009
18
uPA/uPAR downregulation inhibits radiation-induced migration, invasion and angiogenesis in IOMM-Lee meningioma cells and decreases tumor growth in vivo. (18949356)
2008
19
Tissue transgluaminase 2 expression in meningiomas. (18587533)
2008
20
The significance of immunohistochemical expression of Ki-67, p53, p21, and p16 in meningiomas tissue arrays. (18374497)
2008
21
Immunohistochemical expression of apoptosis regulating proteins and sex hormone receptors in meningiomas. (18021195)
2008
22
Progression of astrocytomas and meningiomas: an evaluation in vitro. (17227292)
2007
23
Chordoid meningioma: a report of two cases. (17517194)
2007
24
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. (17894293)
2007
25
Rosai-Dorfman disease mimicking a sphenoid wing meningioma. (15805669)
2005
26
Cerebellar and multiple spinal hemangioblastomas and intraventricular meningioma managed with subtotal resection and external beam radiotherapy; report of a case with literature review. (17357198)
2005
27
Involution of retinochoroidal shunt vessel after radiotherapy for optic nerve sheath meningioma. (15005588)
2004
28
Immunohistochemical study of anaplastic meningioma with special reference to the phenotypic change of intermediate filament protein. (12913843)
2003
29
Case report: microcystic meningioma in a 58-year-old man with multicystic meningioangiomatosis. (12662324)
2003
30
Telomerase activity and expression of the telomerase catalytic subunit, hTERT, in meningioma progression. (10794298)
2000
31
Multiple intracranial and intraspinal meningiomas in the neurocristopathy (phacomatosis) type of neurofibromatosis]. (11378907)
2000
32
Premeatal and retromeatal cerebellopontine angle meningioma. Two distinct clinical entities. (10392201)
1999
33
Intraparenchymal clear cell meningioma of the brainstem in a 2-year-old child. Case report and literature review. (9693326)
1998
34
Preservation of residual vision 2 years after stereotactic radiosurgery for a presumed optic nerve sheath meningioma. (9621268)
1998
35
Lipomatous secretory meningioma: case report and review of the literature. (9833895)
1998
36
Olfactory groove meningioma with paranasal sinus and nasal cavity extension: removal by combined subfrontal and nasal approach. (9819682)
1998
37
Hormones, radiosurgery and virtual reality: new aspects of meningioma management. (9398976)
1997
38
Secretory meningioma with severe perifocal edema--case report. (9301199)
1997
39
Case report: intraventricular meningioma with cerebellopontine angle and drop metastases. (7795983)
1995
40
Role of CD44 in the invasiveness of glioblastoma multiforme and the noninvasiveness of meningioma: an immunohistochemistry study. (7557949)
1995
41
Clear cell meningioma. A clinicopathologic study of a potentially aggressive variant of meningioma. (7726360)
1995
42
Somatic mutations in the neurofibromatosis type 2 gene in sporadic meningiomas. (7868131)
1995
43
Radiation-induced meningioma. (8608584)
1995
44
Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas. (8162072)
1994
45
Secretory meningioma: a case report with immunohistochemical and ultrastructural study. (8220795)
1993
46
Combined supratentorial and infratentorial approach to large pineal-region meningioma. (1536024)
1992
47
Cranioplasty of an extremely large cranial defect caused by transitional meningioma with a knitted polypropylen-polyester prothesis "Codubix". (1776518)
1991
48
Primary optic nerve sheath meningioma. (2611192)
1989
49
The value of enhanced "dynamic" computed tomography in localizing a spinal juxtamedullary meningioma. Enhanced dynamic CT in localizing a spinal meningioma. (3614634)
1987
50
Extradural multiple spinal meningioma. Literature review a case report. (3748265)
1986

Variations for Meningioma

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Meningioma:

1
id Gene Name Type Significance SNP ID Assembly Location
1PTENNM_000314.4(PTEN): c.701G> A (p.Arg234Gln)single nucleotide variantPathogenic, risk factorrs121909235GRCh37Chr 10, 89717676: 89717676

Expression for genes affiliated with Meningioma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meningioma

Search GEO for disease gene expression data for Meningioma.

Pathways for genes affiliated with Meningioma

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51PathCards, 56Reactome, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database, 5Cell Signaling Technology
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Compounds for genes affiliated with Meningioma

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Meningioma according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1eosin4610.6GFAP, VIM, MUC1, S100B
2s 1004610.6GFAP, VIM, MUC1, S100B
3reticulin4610.6GFAP, VIM, MUC1, S100B
4mucicarmine4610.6S100B, MUC1, VIM
5trastuzumab46 52 1212.6PTEN, PGR, MUC1, EGF
64-hydroxytamoxifen4610.6PGR, VIM, S100B, EGF
7hematoxylin4610.5MKI67, GFAP, PTEN, VIM, MUC1, S100B
8fulvestrant46 52 30 1213.5EGF, PGR, MKI67
9progestin4610.5PGR, VIM, MUC1, EGF
10tgf beta14610.5MKI67, PTEN, VIM, ETS1, PDGFB, EGF
11mifepristone46 30 62 1213.5EGF, MUC1, PGR, MKI67
12formaldehyde46 2511.5MKI67, GFAP, VIM, MUC1, S100B
135fluorouracil4610.5MKI67, PTEN, PGR, MUC1, EGF
14bromodeoxyuridine4610.5MKI67, GFAP, VIM, PDGFB, S100B, EGF
15chloramphenicol46 3 52 1213.5S100B, PDGFB, ETS1, MUC1, VIM
16b 7234610.5VIM, MUC1, S100B
17tamoxifen46 52 30 1213.5MKI67, PTEN, PGR, VIM, MUC1, EGF
18glycogen46 2511.5MKI67, GFAP, PTEN, VIM, MUC1, S100B
19matrigel4610.5GFAP, VIM, MUC1, ETS1, EGF
20ethanol46 52 25 1213.5MKI67, GFAP, PTEN, MUC1, S100B
21paclitaxel46 52 1212.4MKI67, GFAP, PTEN, PGR, VIM, S100B
22agar4610.4GFAP, PTEN, PGR, VIM, MUC1, PDGFB
23cycloheximide4610.4MKI67, GFAP, PTEN, PGR, VIM, PDGFB
24pd 98,0594610.4GFAP, PTEN, ETS1, PDGFB, EGF
25thymidine46 2511.4MKI67, GFAP, MUC1, ETS1, PDGFB, S100B
26dihydrotestosterone46 30 25 1213.4EGF, MUC1, VIM, PGR
27cyclic amp46 2511.4GFAP, PTEN, VIM, MUC1, ETS1, S100B
28doxorubicin46 52 1212.4EGF, VIM, PGR, PTEN, MKI67
29estradiol46 25 1212.4MKI67, GFAP, PTEN, PGR, VIM, MUC1
30dexamethasone46 52 30 1213.4GFAP, PGR, VIM, MUC1, PDGFB, S100B
31paraffin4610.4MKI67, GFAP, PTEN, PGR, VIM, MUC1
32testosterone46 62 25 1213.4MKI67, GFAP, PTEN, PGR, VIM, MUC1
33threonine4610.4MKI67, GFAP, PTEN, MUC1, ETS1, S100B
34oxygen46 2511.3MKI67, GFAP, PTEN, MUC1, ETS1, PDGFB
35glucose4610.3MKI67, GFAP, PTEN, MUC1, ETS1, PDGFB
36forskolin46 52 1212.3GFAP, VIM, MUC1, S100B, EGF
37genistein46 30 62 3 25 1215.3GFAP, PTEN, PGR, VIM, EGF
38cysteine4610.3GFAP, PTEN, PGR, VIM, MUC1, ETS1
39vegf4610.3MKI67, GFAP, PTEN, PGR, VIM, MUC1
40retinoic acid46 2511.3PTEN, MN1, GFAP, MKI67, PGR, VIM
41estrogen4610.3MKI67, GFAP, PTEN, PGR, VIM, MUC1
42tyrosine4610.3MKI67, GFAP, PTEN, MUC1, ETS1, PDGFB
43serine4610.3MKI67, GFAP, PTEN, VIM, MUC1, ETS1
44progesterone46 30 62 25 1214.2EGF, MKI67, GFAP, PTEN, PGR, VIM
45arginine4610.2MKI67, GFAP, PTEN, VIM, ETS1, S100B
46glutamine4610.1GFAP, PGR, VIM, S100B, EGF
47folate4610.1MUC1, VIM, PGR, MKI67
48lipid4610.1MKI67, GFAP, PTEN, VIM, MUC1, PDGFB
49alanine4610.1S100B, ETS1, VIM, PGR, PTEN, GFAP
50nitric oxide46 25 1211.8MKI67, PTEN, MUC1, ETS1, PDGFB, S100B

GO Terms for genes affiliated with Meningioma

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17Gene Ontology
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Cellular components related to Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1npBAF complexGO:07156410.4SMARCE1, SMARCB1
2nBAF complexGO:07156510.4SMARCB1, SMARCE1
3nuclear chromosomeGO:00022810.4SMARCE1, SMARCB1
4SWI/SNF complexGO:01651410.3SMARCE1, SMARCB1
5nucleolusGO:00573010.1THOC5, MKI67, SMARCB1, SMARCE1, PTEN, SUFU
6cytoplasmGO:0057379.9NF2, MGEA5, THOC5, MKI67, GFAP, PTEN
7nucleusGO:0056349.6MGEA5, THOC5, MKI67, SMARCB1, SMARCE1, PTEN

Biological processes related to Meningioma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:06002010.6VIM, GFAP
2positive regulation of hyaluronan biosynthetic processGO:190012710.6EGF, PDGFB
3long-term synaptic potentiationGO:06029110.6S100B, PTEN, GFAP
4response to estradiolGO:03235510.5PDGFB, ETS1, PTEN
5negative regulation of cell migrationGO:03033610.5NF2, PDGFB, PTEN
6astrocyte developmentGO:01400210.5GFAP, VIM
7intermediate filament organizationGO:04510910.5VIM, GFAP
8positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.4EGF, PTEN
9positive regulation of cell proliferationGO:00828410.4PTEN, ETS1, PDGFB, S100B, EGF
10fibroblast growth factor receptor signaling pathwayGO:00854310.3EGF, PDGFB, PTEN
11nucleosome disassemblyGO:00633710.3SMARCE1, SMARCB1
12negative regulation of cell proliferationGO:00828510.3SMARCB1, PTEN, ETS1, NF2
13phosphatidylinositol-mediated signalingGO:04801510.0PTEN, PDGFB, EGF

Molecular functions related to Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor bindingGO:00516110.4PDGFB, PTEN
2protein bindingGO:0055159.3EGF, THOC5, MKI67, SMARCB1, SMARCE1, PTEN

Products for genes affiliated with Meningioma

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  • Antibodies
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Sources for Meningioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet