MCID: MNN012
MIFTS: 79

Meningioma malady

Neuronal diseases, Endocrine diseases, Cancer diseases, Genetic diseases categories

Summaries for Meningioma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Meningiomas are benign, slow-growing tumors, classified as brain tumors, but actually growing in the three protective membranes that surround the brain (meninges). sometimes they cause thickening or thinning of adjoining skull bones. meningiomas do not spread to other areas of the body. signs and symptoms vary according to the size and location of the tumor. the exact cause of this condition is unknown. last updated: 7/20/2011

MalaCards: Meningioma, also known as intracranial meningioma, is related to spinal meningioma and benign meningioma. An important gene associated with Meningioma is MN1 (meningioma (disrupted in balanced translocation) 1), and among its related pathways are Rho Family GTPases and PIP3 activates AKT signaling. The drugs mifepristone and cytarabine and the compounds progesterone and vegf have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related mouse phenotypes are mortality/aging and immune system.

Disease Ontology:8 A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid "cap" cells of the arachnoid villi in the meninges.

Wikipedia:63 Meningiomas are a diverse set of tumors arising from the meninges, the membranous layers surrounding the... more...

Description from OMIM:46 606190,607174

Aliases & Classifications for Meningioma

About this section
Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

48
meningioma:
Prevalence: 1-9/100000
familial multiple meningioma:
Inheritance: Autosomal dominant; Age of onset: Variable


Aliases & Descriptions:

meningioma 8 9 42 46 10 44 48 60
intracranial meningioma 8 44 60
supratentorial meningioma 8 60
meningioma, benign, no icd-o subtype 8
meningothelial cell neoplasm 60
familial multiple meningioma 48
meningothelial cell tumor 8
neoplasm of the meninges 8
primary meningeal tumor 8
neoplasm of meninges 8
meningeal neoplasms 60
meningeal neoplasm 8
meningioma nos 8
meningiomas 8


External Ids:

Disease Ontology8 DOID:3565
MeSH34 D008577
NCIt39 C3229
ICD10 via Orphanet26 D32.9
SNOMED-CT via Orphanet57 19453003
UMLS via Orphanet61 C0025286
MESH via Orphanet35 D008579

Related Diseases for Meningioma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Meningioma family:

Benign Meningioma Familial Meningioma
Meningioma, Sis-Related

Diseases related to Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 409)
idRelated DiseaseScoreTop Affiliating Genes
1spinal meningioma31.1SMARCE1, NF2
2benign meningioma31.0NF2, ETS1, EGFL6, PGR
3cerebral meningioma30.8EGF, PGR
4secretory meningioma30.8MUC1, VIM
5rhabdoid meningioma30.8GFAP, VIM
6fibrous meningioma30.7EGFL6, MUC1, NF2, S100B
7neurofibromatosis30.6NF2
8adenoma30.6MUC1, ETS1
9astrocytoma30.5GFAP, PTEN, VIM, ETS1, NF2, S100B
10hemangiopericytoma30.5S100B, VIM, MUC1
11transitional meningioma30.5MUC1, NF2
12leukemia30.4EGF, PDGFB, ETS1, MN1
13adenocarcinoma30.3VIM, PGR, ETS1, EGF, NF2, PTEN
14breast cancer30.2NF2, MUC1, ETS1, EGF, PGR, PTEN
15medulloblastoma30.2PDGFB, S100B, GFAP, SMARCB1, SUFU
16acute leukemia30.2SMARCB1, ETS1
17glioblastoma multiforme30.2EGF, PDGFB, PTEN, GFAP
18hemangioma30.2ETS1
19basal cell carcinoma30.2SUFU
20hemangioblastoma30.1S100B, GFAP, MUC1
21lymphangioleiomyomatosis30.1PGR
22retinoblastoma30.0SMARCB1, EGF, GFAP
23neurilemmoma30.0GFAP, NF2, SMARCB1
24fibrous histiocytoma30.0VIM, S100B
25sarcoma30.0MUC1, ETS1, S100B, VIM, SMARCB1, PDGFB
26melanoma30.0S100B, PTEN, ETS1, NF2, PDGFB, VIM
27chordoma30.0GFAP, VIM, S100B, MUC1
28neurofibroma30.0MUC1, S100B, VIM, NF2
29ischemia30.0ETS1, GFAP, NF2, PDGFB
30choroid plexus papilloma30.0GFAP, MUC1, S100B
31renal clear cell carcinoma29.9PTEN, VIM, MUC1
32perineurioma29.8VIM, S100B, MUC1
33prostate cancer29.8EGF, NF2, ETS1, PTEN
34papillary carcinoma29.8MUC1, ETS1, PGR
35gliosarcoma29.8GFAP, PTEN
36osteosarcoma29.8NF2, PDGFB
37paraganglioma29.8S100B, GFAP
38thyroid cancer29.8ETS1, EGF, PTEN
39ganglioglioma29.8GFAP, S100B
40oligodendroglioma29.8PTEN, GFAP
41histiocytosis29.8S100B
42malignant glioma29.6EGF, GFAP, PTEN, NF2, PDGFB
43tuberous sclerosis29.6VIM, S100B, GFAP, PTEN
44gastrointestinal stromal tumor29.6NF2, VIM, S100B
45chondrosarcoma29.6MUC1, VIM, S100B
46adenoid cystic carcinoma29.6S100B, MUC1, VIM
47clear cell ependymoma29.6MUC1, VIM
48giant cell glioblastoma29.6PTEN, GFAP
49retinal detachment29.6PDGFB, GFAP
50myxopapillary ependymoma29.6S100B, GFAP

Graphical network of the top 20 diseases related to Meningioma:



Diseases related to meningioma

Clinical Features for Meningioma

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

606190,607174

Clinical synopsis from OMIM:

607174

Drugs & Therapeutics for Meningioma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Meningioma

Drug clinical trials:

Search ClinicalTrials for Meningioma

Search NIH Clinical Center for Meningioma

Search CenterWatch for Meningioma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Meningioma

About this section

Anatomical Context for Meningioma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Meningioma:

32
Brain, Bone, Spinal cord, Pituitary, Endothelial, Lung, Breast, Pineal, Thyroid, Prostate, Liver, B cells, Lymph node, Temporal lobe, Myeloid, Skin, Eye, T cells, Placenta, Colon, Cortex, Monocytes, Testis, Testes, Heart, Thymus, Bone marrow, Tongue, Ovary, Olfactory bulb

Animal Models for Meningioma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Meningioma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.5VIM, PDGFB, NF2, MN1, ETS1, PGR
2MP:000538712.4SMARCE1, VIM, PDGFB, EGF, NF2, ETS1
3MP:000537612.2VIM, PDGFB, NF2, MN1, MUC1, ETS1
4MP:000539111.9VIM, PDGFB, EGF, NF2, MUC1, GFAP
5MP:000538011.8VIM, PDGFB, NF2, ETS1, PGR, SUFU
6MP:000200611.7NF2, MN1, MUC1, PGR, SUFU, PTEN
7MP:000287311.7S100B, EGF, EGFL6, MUC1, PGR, GFAP
8MP:000538111.4EGF, MN1, MUC1, GFAP, SUFU, PTEN
9MP:000538511.4VIM, PDGFB, ETS1, PGR, GFAP, SUFU
10MP:000537011.4NF2, MUC1, THOC5, PTEN, SMARCB1, PDGFB
11MP:001077111.2S100B, PDGFB, SUFU, PTEN

Publications for Meningioma

About this section
Sources:
50PubMed
See all sources

Articles related to Meningioma:

(show top 50)    (show all 2121)
idTitleAuthorsYear
1
Lymphoplasmacyte-rich meningioma: our experience with 19 cases and a systematic literature review. (23936588)
2013
2
Cancer metastases to meningioma: apropos two cases. (24374963)
2013
3
Posterior clinoid process meningioma. (23313105)
2013
4
Circulating progenitor cells: a comparison of patients with glioblastoma or meningioma. (22688590)
2013
5
Miniaturized handheld confocal microscopy identifies focal brain invasion in a mouse model of aggressive meningioma. (23356716)
2013
6
Differential expression of extracellular matrix-related genes in rare variants of meningioma. (22995327)
2013
7
Stereotactic radiosurgery used to manage a meningioma filling the posterior two-thirds of the superior sagittal sinus. (23991841)
2013
8
Concomitant Meningioma and Glioma Within the Same Optic Nerve in Neurofibromatosis Type 1. (23420652)
2013
9
Spinal meningioma diagnosis based on transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). (24274451)
2013
10
Bilateral visual loss due to a giant olfactory meningioma. (22419855)
2012
11
Editorial: meningioma and radiotherapy. (22900842)
2012
12
Drainage Pathway of the Superior Petrosal Vein Evaluated by CT Venography in Petroclival Meningioma Surgery. (24083122)
2012
13
Temozolomide combined with radiotherapy in the treatment of recurrent cranial meningioma previously treated with multiple surgical resections and two sessions of radiosurgery: a case report and literature review. (22825521)
2012
14
Cutaneous meningioma. (22288971)
2012
15
Meningioma with intense I(123) FP-CIT uptake. (23283655)
2012
16
Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility. (21091576)
2011
17
Metastatic olfactory neuroblastoma invading a radiation-induced meningioma. (21752653)
2011
18
MMP-9 expression in meningiomas: a prognostic marker for recurrence risk? (20652360)
2011
19
Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status. (20682713)
2010
20
Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma. (20509969)
2010
21
Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas. (19034385)
2009
22
Spinal meningioma surgery in elderly patients with paraplegia or severe paraparesis: a multicenter study. (19240612)
2009
23
Periosteal osteoblastoma of the calvaria mimicking a meningioma. (18359169)
2008
24
Intraoperative fatal pulmonary embolism during resection of a parasagittal meningioma. (18853607)
2008
25
Comprehensive analysis of DNA repair gene variants and risk of meningioma. (18270339)
2008
26
Chordoid meningioma: a report of two cases. (17517194)
2007
27
Gamma Knife surgery for benign meningioma. (17695387)
2007
28
Platelet-activating factor and human meningiomas. (17083481)
2006
29
Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog. (17146188)
2006
30
Supratentorial meningeal melanocytoma mimicking a convexity meningioma. (16391879)
2006
31
Dural plasmacytoma mimicking meningioma in a patient with multiple myeloma. (16459088)
2006
32
Genetic and epigenetic alteration of the NF2 gene in sporadic meningiomas. (15609345)
2005
33
Detection and treatment of optic nerve sheath meningioma. (16131419)
2005
34
Involution of retinochoroidal shunt vessel after radiotherapy for optic nerve sheath meningioma. (15005588)
2004
35
The relationship between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in intracranial meningiomas. (15662977)
2004
36
Immunohistochemical and molecular study of radiation-induced multiple meningiomas with pleural and pulmonary metastasis. (15315314)
2004
37
The Ki-67 proliferation antigen in meningiomas. Experience in 600 cases. (14740263)
2004
38
Chordoid meningioma: report of two cases. (12715027)
2003
39
Clear cell meningioma in a 22-month-old male: update after five years. (12601242)
2003
40
Intraspinal clear cell meningioma: diagnosis and management--report of two cases. (11504136)
2001
41
A novel technique for surgical resection of spinal meningioma. (11493855)
2001
42
Expression of beta1 and beta4 integrins in normal arachnoid membrane and meningiomas. (10594860)
1999
43
Deletion of chromosome 1p and loss of expression of alkaline phosphatase indicate progression of meningiomas. (10589773)
1999
44
Comparative analysis of expression of hepatocyte growth factor and its receptor, c-met, in gliomas, meningiomas and schwannomas in humans. (9500204)
1998
45
Hormones, radiosurgery and virtual reality: new aspects of meningioma management. (9398976)
1997
46
Effect of LINAC radiosurgery on regional cerebral blood flow, glucose metabolism and sodium-potassium AtPase in skull base meningiomas and metastasis. (9233427)
1997
47
Oestrogen receptor independent expression of progestin receptors in human meningioma--a review. (7626481)
1995
48
Microcystic meningioma--a rarely occurring morphological variant of meningioma. (7889343)
1994
49
Correlation of proto-oncogene expression and proliferation and meningiomas. (8133992)
1993
50
Report on 280 cases of verified parasagittal meningioma. (13272053)
1955

Genetic Variations for Meningioma

About this section

Expression for genes affiliated with Meningioma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Meningioma

Search GEO for disease gene expression data for Meningioma.

Pathways for genes affiliated with Meningioma

About this section
Sources:
51QIAGEN, 53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Meningioma

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Meningioma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2416.4VIM, S100B, PDGFB, EGF, NF2, MUC1
2vegf4412.3VIM, S100B, PDGFB, EGF, MUC1, ETS1
3estrogen4412.3VIM, S100B, PDGFB, EGF, MUC1, ETS1
4retinoic acid44 2413.3VIM, S100B, EGF, MN1, MUC1, ETS1
5cysteine4412.3VIM, S100B, EGF, NF2, MUC1, ETS1
6serine4412.2VIM, S100B, PDGFB, EGF, NF2, MUC1
7agar4412.1PTEN, VIM, PDGFB, EGF, NF2, MUC1
8paraffin4412.1VIM, S100B, PDGFB, NF2, MUC1, PGR
9estradiol44 11 2414.0VIM, EGF, MUC1, ETS1, PGR, GFAP
10cyclic amp44 2412.9VIM, S100B, EGF, MUC1, ETS1, GFAP
11testosterone44 59 11 2414.9VIM, S100B, EGF, MUC1, PGR, GFAP
12tyrosine4411.9S100B, PDGFB, EGF, NF2, MUC1, ETS1
13threonine4411.9S100B, EGF, NF2, MUC1, ETS1, GFAP
14thymidine44 2412.8S100B, PDGFB, EGF, MUC1, ETS1, GFAP
15hematoxylin4411.7VIM, S100B, MUC1, GFAP, PTEN
16paclitaxel44 49 1113.7S100B, EGF, PGR, GFAP, PTEN
17bromodeoxyuridine4411.6VIM, S100B, PDGFB, EGF, GFAP
18tgf beta14411.6VIM, PDGFB, EGF, ETS1, PTEN
19alanine4411.6VIM, S100B, ETS1, PGR, GFAP, PTEN
20matrigel4411.6VIM, EGF, MUC1, ETS1, GFAP
21tamoxifen44 49 28 1114.6VIM, EGF, MUC1, PGR, PTEN
22pd 98,0594411.6PDGFB, EGF, ETS1, GFAP, PTEN
23glycogen44 2412.6VIM, S100B, MUC1, GFAP, PTEN
24forskolin44 49 1113.5VIM, S100B, EGF, MUC1, GFAP
25eosin4411.5VIM, S100B, MUC1, GFAP
26genistein44 28 59 2 11 2416.5PTEN, GFAP, PGR, EGF, VIM
27s 1004411.5VIM, S100B, MUC1, GFAP
28reticulin4411.5VIM, S100B, MUC1, GFAP
29trastuzumab44 49 1113.5PTEN, PGR, MUC1, EGF
304-hydroxytamoxifen4411.5VIM, S100B, EGF, PGR
31progestin4411.5VIM, EGF, MUC1, PGR
32dihydrotestosterone44 28 11 2414.4PGR, MUC1, EGF, VIM
33formaldehyde44 2412.4GFAP, MUC1, S100B, VIM
34aspartate4411.4VIM, S100B, PGR, GFAP, PTEN
35adenylate4411.3VIM, S100B, EGF, PGR, GFAP
36dexamethasone44 49 28 1114.3GFAP, PDGFB, S100B
37mucicarmine4411.3VIM, S100B, MUC1
38chloramphenicol44 2 1113.3MUC1, PDGFB, S100B
39oxygen44 2412.3S100B, PDGFB, MUC1, ETS1, GFAP, PTEN
405fluorouracil4411.3EGF, MUC1, PGR, PTEN
41b 7234411.3MUC1, S100B, VIM
42gaba4411.3VIM, S100B, PGR, GFAP
43glutamine4411.1EGF, GFAP
44panitumumab44 49 1113.0PTEN, EGF
45orcein4411.0S100B, VIM
46dbc-amp4411.0VIM, S100B, GFAP
47cycloheximide4411.0PDGFB
48gefitinib44 49 1112.9VIM, EGF, PTEN
4912-o-tetradecanoylphorbol 13-acetate4410.8ETS1, MUC1, EGF, VIM
50butyrate4410.6GFAP

GO Terms for genes affiliated with Meningioma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573712.1PTEN, VIM, S100B, PDGFB, MGEA5, NF2
2SWI/SNF complexGO:01651410.8SMARCE1, SMARCB1
3npBAF complexGO:07156410.7SMARCB1, SMARCE1
4nBAF complexGO:07156510.5SMARCE1, SMARCB1

Biological processes related to Meningioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828411.3S100B, PDGFB, EGF, ETS1, PTEN
2long-term synaptic potentiationGO:06029111.1PTEN, GFAP, S100B
3negative regulation of cell migrationGO:03033610.9PTEN, NF2, PDGFB
4Bergmann glial cell differentiationGO:06002010.9GFAP, VIM
5positive regulation of hyaluronan biosynthetic processGO:190012710.9EGF, PDGFB
6positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.8PTEN, EGF
7astrocyte developmentGO:01400210.7VIM, GFAP
8intermediate filament organizationGO:04510910.5GFAP, VIM

Molecular functions related to Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.7SMARCE1, S100B, PDGFB, AP1B1, EGF, NF2

Products for genes affiliated with Meningioma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Meningioma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet