MCID: MNN012
MIFTS: 79

Meningioma malady

Neuronal diseases, Endocrine diseases, Cancer diseases, Genetic diseases categories

Summaries for Meningioma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Meningiomas are benign, slow-growing tumors, classified as brain tumors, but actually growing in the three protective membranes that surround the brain (meninges). sometimes they cause thickening or thinning of adjoining skull bones. meningiomas do not spread to other areas of the body. signs and symptoms vary according to the size and location of the tumor. the exact cause of this condition is unknown. last updated: 7/20/2011

MalaCards: Meningioma, also known as intracranial meningioma, is related to spinal meningioma and benign meningioma. An important gene associated with Meningioma is MN1 (meningioma (disrupted in balanced translocation) 1), and among its related pathways are Rho Family GTPases and PIP3 activates AKT signaling. The drugs cytarabine and mifepristone and the compounds progesterone and vegf have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related mouse phenotypes are mortality/aging and immune system.

Disease Ontology:8 A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid "cap" cells of the arachnoid villi in the meninges.

Wikipedia:63 Meningiomas are a diverse set of tumors arising from the meninges, the membranous layers surrounding the... more...

Description from OMIM:46 606190,607174

Aliases & Classifications for Meningioma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
meningioma:
Prevalence: 1-9/100000
familial multiple meningioma:
Inheritance: Autosomal dominant; Age of onset: Variable


Aliases & Descriptions:

meningioma 8 9 42 46 10 44 48 60
intracranial meningioma 8 44 60
supratentorial meningioma 8 60
meningioma, benign, no icd-o subtype 8
meningothelial cell neoplasm 60
familial multiple meningioma 48
meningothelial cell tumor 8
neoplasm of the meninges 8
primary meningeal tumor 8
neoplasm of meninges 8
meningeal neoplasms 60
meningeal neoplasm 8
meningioma nos 8
meningiomas 8


External Ids:

Disease Ontology8 DOID:3565
MeSH34 D008577
NCIt39 C3229
ICD10 via Orphanet26 D32.9
SNOMED-CT via Orphanet57 19453003
UMLS via Orphanet61 C0025286
MESH via Orphanet35 D008579

Related Diseases for Meningioma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Meningioma family:

Benign Meningioma Familial Meningioma
Meningioma, Sis-Related

Diseases related to Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 409)
idRelated DiseaseScoreTop Affiliating Genes
1spinal meningioma31.1SMARCE1, NF2
2benign meningioma31.0NF2, ETS1, EGFL6, PGR
3cerebral meningioma30.8EGF, PGR
4secretory meningioma30.8MUC1, VIM
5rhabdoid meningioma30.8GFAP, VIM
6fibrous meningioma30.7EGFL6, MUC1, NF2, S100B
7neurofibromatosis30.6NF2
8adenoma30.6MUC1, ETS1
9astrocytoma30.5GFAP, PTEN, VIM, ETS1, NF2, S100B
10hemangiopericytoma30.5S100B, VIM, MUC1
11transitional meningioma30.5MUC1, NF2
12leukemia30.4EGF, PDGFB, ETS1, MN1
13adenocarcinoma30.3VIM, PGR, ETS1, EGF, NF2, PTEN
14breast cancer30.2NF2, MUC1, ETS1, EGF, PGR, PTEN
15medulloblastoma30.2PDGFB, S100B, GFAP, SMARCB1, SUFU
16acute leukemia30.2SMARCB1, ETS1
17glioblastoma multiforme30.2EGF, PDGFB, PTEN, GFAP
18hemangioma30.2ETS1
19basal cell carcinoma30.2SUFU
20hemangioblastoma30.1S100B, GFAP, MUC1
21lymphangioleiomyomatosis30.1PGR
22retinoblastoma30.0SMARCB1, EGF, GFAP
23neurilemmoma30.0GFAP, NF2, SMARCB1
24fibrous histiocytoma30.0VIM, S100B
25sarcoma30.0MUC1, ETS1, S100B, VIM, SMARCB1, PDGFB
26melanoma30.0S100B, PTEN, ETS1, NF2, PDGFB, VIM
27chordoma30.0GFAP, VIM, S100B, MUC1
28neurofibroma30.0MUC1, S100B, VIM, NF2
29ischemia30.0ETS1, GFAP, NF2, PDGFB
30choroid plexus papilloma30.0GFAP, MUC1, S100B
31renal clear cell carcinoma29.9PTEN, VIM, MUC1
32perineurioma29.8VIM, S100B, MUC1
33prostate cancer29.8EGF, NF2, ETS1, PTEN
34papillary carcinoma29.8MUC1, ETS1, PGR
35gliosarcoma29.8GFAP, PTEN
36osteosarcoma29.8NF2, PDGFB
37paraganglioma29.8S100B, GFAP
38thyroid cancer29.8ETS1, EGF, PTEN
39ganglioglioma29.8GFAP, S100B
40oligodendroglioma29.8PTEN, GFAP
41histiocytosis29.8S100B
42malignant glioma29.6EGF, GFAP, PTEN, NF2, PDGFB
43tuberous sclerosis29.6VIM, S100B, GFAP, PTEN
44gastrointestinal stromal tumor29.6NF2, VIM, S100B
45chondrosarcoma29.6MUC1, VIM, S100B
46adenoid cystic carcinoma29.6S100B, MUC1, VIM
47clear cell ependymoma29.6MUC1, VIM
48giant cell glioblastoma29.6PTEN, GFAP
49retinal detachment29.6PDGFB, GFAP
50myxopapillary ependymoma29.6S100B, GFAP

Graphical network of the top 20 diseases related to Meningioma:



Diseases related to meningioma

Clinical Features for Meningioma

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Sources:
46OMIM
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Clinical features from OMIM:

606190,607174

Clinical synopsis from OMIM:

607174

Drugs & Therapeutics for Meningioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Meningioma

Drug clinical trials:

Search ClinicalTrials for Meningioma

Search NIH Clinical Center for Meningioma

Search CenterWatch for Meningioma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Meningioma

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Anatomical Context for Meningioma

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32MalaCards
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MalaCards organs/tissues related to Meningioma:

32
Brain, Bone, Spinal cord, Pituitary, Endothelial, Lung, Breast, Pineal, Thyroid, Prostate, Liver, B cells, Lymph node, Temporal lobe, Myeloid, Skin, Eye, T cells, Placenta, Colon, Cortex, Monocytes, Testis, Testes, Heart, Thymus, Bone marrow, Tongue, Ovary, Olfactory bulb

Animal Models for Meningioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Meningioma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.5VIM, PDGFB, NF2, MN1, ETS1, PGR
2MP:000538712.4SMARCE1, VIM, PDGFB, EGF, NF2, ETS1
3MP:000537612.2VIM, PDGFB, NF2, MN1, MUC1, ETS1
4MP:000539111.9VIM, PDGFB, EGF, NF2, MUC1, GFAP
5MP:000538011.8VIM, PDGFB, NF2, ETS1, PGR, SUFU
6MP:000200611.7NF2, MN1, MUC1, PGR, SUFU, PTEN
7MP:000287311.7S100B, EGF, EGFL6, MUC1, PGR, GFAP
8MP:000538111.4EGF, MN1, MUC1, GFAP, SUFU, PTEN
9MP:000538511.4VIM, PDGFB, ETS1, PGR, GFAP, SUFU
10MP:000537011.4NF2, MUC1, THOC5, PTEN, SMARCB1, PDGFB
11MP:001077111.2S100B, PDGFB, SUFU, PTEN

Publications for Meningioma

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50PubMed
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Articles related to Meningioma:

(show top 50)    (show all 2121)
idTitleAuthorsYear
1
Clinical value of multi-slice 3-dimensional computed tomographic angiography in the preoperative assessment of meningioma. (24137211)
2013
2
Radiation Optic Neuropathy After Proton Beam Therapy for Optic Nerve Sheath Meningioma. (24128652)
2013
3
Indocyanine green videography and meningioma. (24010970)
2013
4
Early postoperative radiotherapy improves progression free survival in patients with grade 2 meningioma. (23728501)
2013
5
Usefulness of 320-row area detector computed tomography for the diagnosis of cystic falx meningioma. (23898282)
2013
6
Dental x-rays and risk of meningioma: response to Drs. Calnon, Jorgensen, and White. (23254687)
2013
7
Skull base meningiomas mimicking otitis media. (22494527)
2012
8
An immunohistochemical study of HER2 expression in meningioma and its correlation with tumor grade. (22420924)
2012
9
Giant velum interpositum meningioma in a child. (23248425)
2012
10
Reirradiation of recurrent meningioma. (22784877)
2012
11
Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum. (23285163)
2012
12
Germline SMARCB1 mutation predisposes to multiple meningiomas and schwannomas with preferential location of cranial meningiomas at the falx cerebri. (22038540)
2012
13
Microvascularization and expression of VEGF and its receptors in recurring meningiomas: pathobiological data in favor of anti-angiogenic therapy approaches. (22541785)
2012
14
Hypermethylation and transcriptional downregulation of the TIMP3 gene is associated with allelic loss on 22q12.3 and malignancy in meningiomas. (19922547)
2010
15
Aquaporin-4 expression is increased in edematous meningiomas. (19153045)
2009
16
Radiation-induced meningioma concealed by shunt valve artifact: case report. (18424999)
2008
17
XRCC1 and XRCC3 variants and risk of glioma and meningioma. (18330515)
2008
18
Bilateral epidural extension of thoracic capillary vertebral (intraosseous) hemangioma mimicking spinal meningioma. (18942307)
2008
19
Cacosmia secondary to an olfactory groove meningioma. (18684347)
2007
20
Radiation-induced meningioma following prophylactic radiotherapy for acute lymphoblastic leukemia in childhood. (17190987)
2007
21
Lymphoplasmacyte-rich meningioma mimicking idiopathic hypertrophic pachymeningitis. (17548990)
2007
22
Proliferation potential of spinal meningiomas. (15926055)
2006
23
A sphenoid en plaque meningioma aggravates exophthalmos in a patient with thyroid ophthalmopathy. (16761251)
2006
24
Low-field MR imaging of meningiomas including dynamic contrast enhancement study: evaluation of surgical and histopathologic characteristics. (17110681)
2006
25
High throughput screening of meningioma biomarkers using a tissue microarray. (15980972)
2005
26
Peritumoral brain edema in intracranial meningiomas. (16165364)
2005
27
Parasagittal meningioma en plaque with extracranial extension presenting diffuse massive hyperostosis of the skull. (14751632)
2004
28
Primary ear and temporal bone meningiomas: a clinicopathologic study of 36 cases with a review of the literature. (12640104)
2003
29
Immunohistochemical expression of cathepsin D in meningiomas. (12520707)
2003
30
Molecular heterogeneity of meningioma with INI1 mutation. (14514925)
2003
31
Stereotactic irradiation of biopsy proved optic nerve sheath meningioma. (12543765)
2003
32
Estrogen and progesterone receptors in cerebral meningioma and their clinical value]. (12378940)
2002
33
An anterior ethmoidal artery aneurysm associated with an olfactory groove meningioma. Case illustration. (12507153)
2002
34
Ossified thoracic spinal meningioma in childhood: a case report and review of the literature. (11714573)
2001
35
Quantitative analysis of NF1 and OMGP gene transcripts in sporadic gliomas, sporadic meningiomas and neurofibromatosis type 1-associated plexiform neurofibromas. (10378372)
1999
36
Primary midline cranial vault lymphoma simulating a parasagittal meningioma: the role of angiography in preoperative diagnosis. (9795963)
1998
37
Secretory meningioma with severe perifocal edema--case report. (9301199)
1997
38
Meningioma. Classification and grading]. (9432670)
1997
39
Radiation-induced meningioma in children: report of two cases and review of the literature. (8753667)
1996
40
Advanced nasopharyngeal carcinoma and radiation-induced meningioma in dizygotic twins--a rare case report. (8938229)
1996
41
Occipital falcine meningioma presenting with ipsilateral hemifacial spasm: a case report. (9115659)
1996
42
Petroclival meningioma mimicking the presentation of a transient ischemic attack. (8178634)
1994
43
Structure and expression of the c-sis gene and its relationship to sporadic meningiomas. (1868450)
1991
44
Foramen magnum meningioma: transoral resection with a bone baffle to prevent CSF leakage. Case report. (2303883)
1990
45
Lack of efficacy of megestrol acetate in the treatment of unresectable meningioma. (2319292)
1990
46
Primary optic nerve sheath meningioma. (2611192)
1989
47
Extradural multiple spinal meningioma. Literature review a case report. (3748265)
1986
48
A large convexity meningioma followed by liquorrhoea from a nasal encephalocele. A case report. (7315558)
1981
49
Roentgenographically visible calcifications in spinal meningioma. (4810300)
1974
50
Choroid plexus meningioma of the lateral ventricle: two cases demonstrated by brain scanning. (5300176)
1968

Genetic Variations for Meningioma

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Expression for genes affiliated with Meningioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meningioma

Search GEO for disease gene expression data for Meningioma.

Pathways for genes affiliated with Meningioma

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Meningioma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Meningioma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2416.4GFAP, VIM, S100B, PTEN, PGR, MUC1
2vegf4412.3PDGFB, PGR, S100B, VIM, EGF, MUC1
3estrogen4412.3PGR, PTEN, ETS1, MUC1, EGF, PDGFB
4retinoic acid44 2413.3EGF, S100B, VIM, MUC1, MN1, ETS1
5cysteine4412.3PGR, VIM, S100B, EGF, MUC1, ETS1
6serine4412.2S100B, MUC1, GFAP, PTEN, VIM, EGF
7agar4412.1PTEN, GFAP, PGR, MUC1, NF2, EGF
8paraffin4412.1VIM, S100B, PTEN, MUC1, PDGFB, NF2
9estradiol44 11 2414.0GFAP, ETS1, MUC1, EGF, VIM, PGR
10cyclic amp44 2412.9EGF, S100B, VIM, GFAP, PTEN, MUC1
11testosterone44 59 11 2414.9MUC1, VIM, S100B, EGF, PTEN, GFAP
12tyrosine4411.9NF2, S100B, PDGFB, EGF, MUC1, ETS1
13threonine4411.9MUC1, NF2, ETS1, GFAP, PTEN, EGF
14thymidine44 2412.8S100B, GFAP, ETS1, MUC1, EGF, PDGFB
15hematoxylin4411.7PTEN, GFAP, MUC1, S100B, VIM
16paclitaxel44 49 1113.7GFAP, PGR, S100B, PTEN, EGF
17bromodeoxyuridine4411.6GFAP, EGF, PDGFB, S100B, VIM
18tgf beta14411.6EGF, PDGFB, PTEN, ETS1, VIM
19alanine4411.6ETS1, GFAP, S100B, PTEN, VIM, PGR
20matrigel4411.6MUC1, EGF, ETS1, GFAP, VIM
21tamoxifen44 49 28 1114.6VIM, EGF, MUC1, PGR, PTEN
22pd 98,0594411.6EGF, PDGFB, PTEN, GFAP, ETS1
23glycogen44 2412.6MUC1, GFAP, PTEN, S100B, VIM
24forskolin44 49 1113.5S100B, EGF, MUC1, GFAP, VIM
25eosin4411.5S100B, GFAP, MUC1, VIM
26genistein44 28 59 2 11 2416.5GFAP, PGR, EGF, VIM, PTEN
27s 1004411.5MUC1, VIM, S100B, GFAP
28reticulin4411.5VIM, GFAP, S100B, MUC1
29trastuzumab44 49 1113.5PGR, MUC1, PTEN, EGF
304-hydroxytamoxifen4411.5PGR, VIM, S100B, EGF
31progestin4411.5EGF, MUC1, PGR, VIM
32dihydrotestosterone44 28 11 2414.4VIM, PGR, MUC1, EGF
33formaldehyde44 2412.4GFAP, S100B, MUC1, VIM
34aspartate4411.4VIM, S100B, PGR, GFAP, PTEN
35adenylate4411.3EGF, GFAP, S100B, VIM, PGR
36dexamethasone44 49 28 1114.3S100B, PDGFB, GFAP
37mucicarmine4411.3VIM, S100B, MUC1
38chloramphenicol44 2 1113.3PDGFB, S100B, MUC1
39oxygen44 2412.3PTEN, S100B, GFAP, ETS1, MUC1, PDGFB
405fluorouracil4411.3EGF, MUC1, PGR, PTEN
41b 7234411.3VIM, MUC1, S100B
42gaba4411.3PGR, GFAP, S100B, VIM
43glutamine4411.1EGF, GFAP
44panitumumab44 49 1113.0PTEN, EGF
45orcein4411.0VIM, S100B
46gefitinib44 49 1113.0PTEN, EGF, VIM
47cycloheximide4411.0PDGFB
48dbc-amp4410.9GFAP, S100B, VIM
4912-o-tetradecanoylphorbol 13-acetate4410.8VIM, ETS1, EGF, MUC1
50butyrate4410.6GFAP

GO Terms for genes affiliated with Meningioma

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16Gene Ontology
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Cellular components related to Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573712.1PTEN, VIM, S100B, PDGFB, MGEA5, NF2
2SWI/SNF complexGO:01651410.8SMARCE1, SMARCB1
3npBAF complexGO:07156410.7SMARCB1, SMARCE1
4nBAF complexGO:07156510.5SMARCE1, SMARCB1

Biological processes related to Meningioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828411.3S100B, PDGFB, EGF, ETS1, PTEN
2long-term synaptic potentiationGO:06029111.1PTEN, GFAP, S100B
3negative regulation of cell migrationGO:03033610.9PTEN, NF2, PDGFB
4Bergmann glial cell differentiationGO:06002010.9GFAP, VIM
5positive regulation of hyaluronan biosynthetic processGO:190012710.9EGF, PDGFB
6positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.8PTEN, EGF
7astrocyte developmentGO:01400210.7VIM, GFAP
8intermediate filament organizationGO:04510910.5GFAP, VIM

Molecular functions related to Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.7SMARCE1, S100B, PDGFB, AP1B1, EGF, NF2

Products for genes affiliated with Meningioma

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  • Antibodies
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Sources for Meningioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet