MCID: MNN012
MIFTS: 79

Meningioma malady

Neuronal diseases, Endocrine diseases, Cancer diseases, Genetic diseases categories

Summaries for Meningioma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Meningiomas are benign, slow-growing tumors, classified as brain tumors, but actually growing in the three protective membranes that surround the brain (meninges). sometimes they cause thickening or thinning of adjoining skull bones. meningiomas do not spread to other areas of the body. signs and symptoms vary according to the size and location of the tumor. the exact cause of this condition is unknown. last updated: 7/20/2011

MalaCards: Meningioma, also known as intracranial meningioma, is related to spinal meningioma and benign meningioma. An important gene associated with Meningioma is MN1 (meningioma (disrupted in balanced translocation) 1), and among its related pathways are Rho Family GTPases and PIP3 activates AKT signaling. The drugs cytarabine and mifepristone and the compounds progesterone and vegf have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related mouse phenotypes are mortality/aging and immune system.

Disease Ontology:8 A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid "cap" cells of the arachnoid villi in the meninges.

Wikipedia:63 Meningiomas are a diverse set of tumors arising from the meninges, the membranous layers surrounding the... more...

Description from OMIM:46 606190,607174

Aliases & Classifications for Meningioma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
meningioma:
Prevalence: 1-9/100000
familial multiple meningioma:
Inheritance: Autosomal dominant; Age of onset: Variable


Aliases & Descriptions:

meningioma 8 9 42 46 10 44 48 60
intracranial meningioma 8 44 60
supratentorial meningioma 8 60
meningioma, benign, no icd-o subtype 8
meningothelial cell neoplasm 60
familial multiple meningioma 48
meningothelial cell tumor 8
neoplasm of the meninges 8
primary meningeal tumor 8
neoplasm of meninges 8
meningeal neoplasms 60
meningeal neoplasm 8
meningioma nos 8
meningiomas 8


External Ids:

Disease Ontology8 DOID:3565
MeSH34 D008577
NCIt39 C3229
ICD10 via Orphanet26 D32.9
SNOMED-CT via Orphanet57 19453003
UMLS via Orphanet61 C0025286
MESH via Orphanet35 D008579

Related Diseases for Meningioma

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17GeneCards, 18GeneDecks
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Diseases in the Meningioma family:

Benign Meningioma Familial Meningioma
Meningioma, Sis-Related

Diseases related to Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 409)
idRelated DiseaseScoreTop Affiliating Genes
1spinal meningioma31.1SMARCE1, NF2
2benign meningioma31.0NF2, ETS1, EGFL6, PGR
3cerebral meningioma30.8EGF, PGR
4secretory meningioma30.8MUC1, VIM
5rhabdoid meningioma30.8GFAP, VIM
6fibrous meningioma30.7EGFL6, MUC1, NF2, S100B
7neurofibromatosis30.6NF2
8adenoma30.6MUC1, ETS1
9astrocytoma30.5GFAP, PTEN, VIM, ETS1, NF2, S100B
10hemangiopericytoma30.5S100B, VIM, MUC1
11transitional meningioma30.5MUC1, NF2
12leukemia30.4EGF, PDGFB, ETS1, MN1
13adenocarcinoma30.3VIM, PGR, ETS1, EGF, NF2, PTEN
14breast cancer30.2NF2, MUC1, ETS1, EGF, PGR, PTEN
15medulloblastoma30.2PDGFB, S100B, GFAP, SMARCB1, SUFU
16acute leukemia30.2SMARCB1, ETS1
17glioblastoma multiforme30.2EGF, PDGFB, PTEN, GFAP
18hemangioma30.2ETS1
19basal cell carcinoma30.2SUFU
20hemangioblastoma30.1S100B, GFAP, MUC1
21lymphangioleiomyomatosis30.1PGR
22retinoblastoma30.0SMARCB1, EGF, GFAP
23neurilemmoma30.0GFAP, NF2, SMARCB1
24fibrous histiocytoma30.0VIM, S100B
25sarcoma30.0MUC1, ETS1, S100B, VIM, SMARCB1, PDGFB
26melanoma30.0S100B, PTEN, ETS1, NF2, PDGFB, VIM
27chordoma30.0GFAP, VIM, S100B, MUC1
28neurofibroma30.0MUC1, S100B, VIM, NF2
29ischemia30.0ETS1, GFAP, NF2, PDGFB
30choroid plexus papilloma30.0GFAP, MUC1, S100B
31renal clear cell carcinoma29.9PTEN, VIM, MUC1
32perineurioma29.8VIM, S100B, MUC1
33prostate cancer29.8EGF, NF2, ETS1, PTEN
34papillary carcinoma29.8MUC1, ETS1, PGR
35gliosarcoma29.8GFAP, PTEN
36osteosarcoma29.8NF2, PDGFB
37paraganglioma29.8S100B, GFAP
38thyroid cancer29.8ETS1, EGF, PTEN
39ganglioglioma29.8GFAP, S100B
40oligodendroglioma29.8PTEN, GFAP
41histiocytosis29.8S100B
42malignant glioma29.6EGF, GFAP, PTEN, NF2, PDGFB
43tuberous sclerosis29.6VIM, S100B, GFAP, PTEN
44gastrointestinal stromal tumor29.6NF2, VIM, S100B
45chondrosarcoma29.6MUC1, VIM, S100B
46adenoid cystic carcinoma29.6S100B, MUC1, VIM
47clear cell ependymoma29.6MUC1, VIM
48giant cell glioblastoma29.6PTEN, GFAP
49retinal detachment29.6PDGFB, GFAP
50myxopapillary ependymoma29.6S100B, GFAP

Graphical network of the top 20 diseases related to Meningioma:



Diseases related to meningioma

Clinical Features for Meningioma

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Sources:
46OMIM
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Clinical features from OMIM:

606190,607174

Clinical synopsis from OMIM:

607174

Drugs & Therapeutics for Meningioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Meningioma

Drug clinical trials:

Search ClinicalTrials for Meningioma

Search NIH Clinical Center for Meningioma

Search CenterWatch for Meningioma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Meningioma

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Anatomical Context for Meningioma

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32MalaCards
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MalaCards organs/tissues related to Meningioma:

32
Brain, Bone, Spinal cord, Pituitary, Endothelial, Lung, Breast, Pineal, Thyroid, Prostate, Liver, B cells, Lymph node, Temporal lobe, Myeloid, Skin, Eye, T cells, Placenta, Colon, Cortex, Monocytes, Testis, Testes, Heart, Thymus, Bone marrow, Tongue, Ovary, Olfactory bulb

Animal Models for Meningioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Meningioma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.5VIM, PDGFB, NF2, MN1, ETS1, PGR
2MP:000538712.4SMARCE1, VIM, PDGFB, EGF, NF2, ETS1
3MP:000537612.2VIM, PDGFB, NF2, MN1, MUC1, ETS1
4MP:000539111.9VIM, PDGFB, EGF, NF2, MUC1, GFAP
5MP:000538011.8VIM, PDGFB, NF2, ETS1, PGR, SUFU
6MP:000200611.7NF2, MN1, MUC1, PGR, SUFU, PTEN
7MP:000287311.7S100B, EGF, EGFL6, MUC1, PGR, GFAP
8MP:000538111.4EGF, MN1, MUC1, GFAP, SUFU, PTEN
9MP:000538511.4VIM, PDGFB, ETS1, PGR, GFAP, SUFU
10MP:000537011.4NF2, MUC1, THOC5, PTEN, SMARCB1, PDGFB
11MP:001077111.2S100B, PDGFB, SUFU, PTEN

Publications for Meningioma

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50PubMed
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Articles related to Meningioma:

(show top 50)    (show all 2121)
idTitleAuthorsYear
1
An unusual and reversible cause of falls: spinal meningioma in an elderly woman. (23311562)
2013
2
Emerging association between androgen deprivation therapy and male meningioma: significant expression of luteinizing hormone-releasing hormone receptor in male meningioma. (24100643)
2013
3
Meningioma surgery in the very old-validating prognostic scoring systems. (24026231)
2013
4
Parotid gland metastasis originating from malignant meningioma. (23768739)
2013
5
Combined PET/MR imaging using (68)Ga-DOTATOC for radiotherapy treatment planning in meningioma patients. (22918773)
2013
6
Analysis of a synchronous gliosarcoma and meningioma with long survival: A case report and review of the literature. (24381794)
2013
7
Peritumoral brain edema in intracranial meningiomas: the emergence of vascular endothelial growth factor-directed therapy. (24289127)
2013
8
Is there an association between Vogt-Koyonagi-Harada syndrome and intracranial meningioma? (22669216)
2012
9
Surgery for convexity meningioma: Simpson Grade I resection as the goal: clinical article. (23061394)
2012
10
Fatal hemorrhagic infarction of posterior fossa meningioma during cardiopulmonary bypass. (22269734)
2012
11
Validation of the superior interhemispheric approach for tuberculum sellae meningioma: clinical article. (23061383)
2012
12
Osteopontin predicts the behaviour of atypical meningioma. (22211290)
2012
13
Vascular endothelial growth factor A protein level and gene expression in intracranial meningiomas with brain edema. (22085359)
2011
14
Primary spinal meningioma in a 10-year-old boy. (21049198)
2010
15
Synchronous meningioma and anaplastic large cell lymphoma. (19751246)
2010
16
Clear cell meningioma of the fourth ventricle in a child: a case report and literature review. (21540624)
2010
17
Giant atypical intraventricular meningioma presenting with visual loss in a child. (20614255)
2010
18
Fatty acid synthase as a novel target for meningioma therapy. (20511185)
2010
19
Immunohistochemical comparison of chordoma with chondrosarcoma, myxopapillary ependymoma, and chordoid meningioma. (19521276)
2009
20
Transient focal spinal cord hyperemia after resection of spinal meningioma: case report. (19487865)
2009
21
Tissue transgluaminase 2 expression in meningiomas. (18587533)
2008
22
Chordoid meningioma: presentation of two case reports, review of the literature, and plea for data standardisation. (18320142)
2008
23
Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. (19122989)
2008
24
A case of malignant meningioma treated by individual adjuvant chemotherapy based on the mRNA expression of drug-resistance gene]. (17301541)
2007
25
Durectomy and reconstruction for the treatment of a recurrent spinal meningioma. Case report. (16850962)
2006
26
Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas. (15832773)
2005
27
Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. (16103061)
2005
28
Epidermal growth factor receptor family (EGFR, ErbB2-4) in gliomas and meningiomas. (15148612)
2004
29
Isolated intracranial Rosai-Dorfman disease mimicking meningioma in a child. (15327236)
2004
30
Synchronous basal cell carcinoma and meningioma following cranial irradiation for a pilocytic astrocytoma. (12820764)
2003
31
A new germline mutation of the PTCH gene in a Japanese patient with nevoid basal cell carcinoma syndrome associated with meningioma. (12604725)
2003
32
Development of a meningioma in a patient with acromegaly during octreotide treatment: are there any causal relationships? (12841545)
2003
33
Pathological laughter as a presenting symptom of petroclival meningioma--case report. (11760387)
2001
34
Ultrastructural examination is essential for diagnosis of papillary meningioma. (11318897)
2001
35
Multiple intracranial and intraspinal meningiomas in the neurocristopathy (phacomatosis) type of neurofibromatosis]. (11378907)
2000
36
Petroclival meningioma as a cause of ipsilateral cervicofacial dyskinesis. (10671125)
2000
37
Multiple meningiomas, craniofacial hyperostosis and retinal abnormalities in Proteus syndrome. (10925389)
2000
38
Multifocal clear cell meningioma in the spine: a case report. (9795955)
1998
39
Intracranial epithelioid hemangioendothelioma arising at site of previously excised atypical meningioma. (9643485)
1998
40
Role of CD44 in the invasiveness of glioblastoma multiforme and the noninvasiveness of meningioma: an immunohistochemistry study. (7557949)
1995
41
Deletions on chromosome 22 in sporadic meningioma. (7520265)
1994
42
Functional analysis of an alternatively spliced estrogen receptor lacking exon 4 isolated from MCF-7 breast cancer cells and meningioma tissue. (9397958)
1994
43
Expression of PDGF, PDGF-receptor, EGF-receptor and sex hormone receptors on meningioma. (7754837)
1994
44
Benign meningioma with a short latency period following irradiation. (1440212)
1992
45
Foster Kennedy syndrome and optociliary shunt vessels in a patient with an olfactory groove meningioma. (1923304)
1991
46
Inhibition of the growth of cultured human meningioma cells by recombinant interferon-alpha. (1828169)
1991
47
Meningioma occurring twenty-three years after a successfully treated cerebellar medulloblastoma: case report. (3475054)
1987
48
Parasagittal meningioma associated with metastasis by ovarian carcinoma. (7282472)
1981
49
Parapharyngeal meningioma with special reference to cell of origin. (5578792)
1971
50
Foot and leg symptoms referrable to bilateral cerebral meningioma--a case report. (14028016)
1962

Genetic Variations for Meningioma

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Expression for genes affiliated with Meningioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meningioma

Search GEO for disease gene expression data for Meningioma.

Pathways for genes affiliated with Meningioma

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Meningioma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Meningioma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2416.4GFAP, VIM, S100B, PTEN, PGR, MUC1
2vegf4412.3PDGFB, PGR, S100B, VIM, EGF, MUC1
3estrogen4412.3PGR, PTEN, ETS1, MUC1, EGF, PDGFB
4retinoic acid44 2413.3EGF, S100B, VIM, MUC1, MN1, ETS1
5cysteine4412.3PGR, VIM, S100B, EGF, MUC1, ETS1
6serine4412.2S100B, MUC1, GFAP, PTEN, VIM, EGF
7agar4412.1PTEN, GFAP, PGR, MUC1, NF2, EGF
8paraffin4412.1VIM, S100B, PTEN, MUC1, PDGFB, NF2
9estradiol44 11 2414.0GFAP, ETS1, MUC1, EGF, VIM, PGR
10cyclic amp44 2412.9EGF, S100B, VIM, GFAP, PTEN, MUC1
11testosterone44 59 11 2414.9MUC1, VIM, S100B, EGF, PTEN, GFAP
12tyrosine4411.9NF2, S100B, PDGFB, EGF, MUC1, ETS1
13threonine4411.9MUC1, NF2, ETS1, GFAP, PTEN, EGF
14thymidine44 2412.8S100B, GFAP, ETS1, MUC1, EGF, PDGFB
15hematoxylin4411.7PTEN, GFAP, MUC1, S100B, VIM
16paclitaxel44 49 1113.7GFAP, PGR, S100B, PTEN, EGF
17bromodeoxyuridine4411.6GFAP, EGF, PDGFB, S100B, VIM
18tgf beta14411.6EGF, PDGFB, PTEN, ETS1, VIM
19alanine4411.6ETS1, GFAP, S100B, PTEN, VIM, PGR
20matrigel4411.6MUC1, EGF, ETS1, GFAP, VIM
21tamoxifen44 49 28 1114.6VIM, EGF, MUC1, PGR, PTEN
22pd 98,0594411.6EGF, PDGFB, PTEN, GFAP, ETS1
23glycogen44 2412.6MUC1, GFAP, PTEN, S100B, VIM
24forskolin44 49 1113.5S100B, EGF, MUC1, GFAP, VIM
25eosin4411.5S100B, GFAP, MUC1, VIM
26genistein44 28 59 2 11 2416.5GFAP, PGR, EGF, VIM, PTEN
27s 1004411.5MUC1, VIM, S100B, GFAP
28reticulin4411.5VIM, GFAP, S100B, MUC1
29trastuzumab44 49 1113.5PGR, MUC1, PTEN, EGF
304-hydroxytamoxifen4411.5PGR, VIM, S100B, EGF
31progestin4411.5EGF, MUC1, PGR, VIM
32dihydrotestosterone44 28 11 2414.4VIM, PGR, MUC1, EGF
33formaldehyde44 2412.4GFAP, S100B, MUC1, VIM
34aspartate4411.4VIM, S100B, PGR, GFAP, PTEN
35adenylate4411.3EGF, GFAP, S100B, VIM, PGR
36dexamethasone44 49 28 1114.3S100B, PDGFB, GFAP
37mucicarmine4411.3VIM, S100B, MUC1
38chloramphenicol44 2 1113.3PDGFB, S100B, MUC1
39oxygen44 2412.3PTEN, S100B, GFAP, ETS1, MUC1, PDGFB
405fluorouracil4411.3EGF, MUC1, PGR, PTEN
41b 7234411.3VIM, MUC1, S100B
42gaba4411.3PGR, GFAP, S100B, VIM
43glutamine4411.1EGF, GFAP
44panitumumab44 49 1113.0PTEN, EGF
45orcein4411.0VIM, S100B
46gefitinib44 49 1113.0PTEN, EGF, VIM
47cycloheximide4411.0PDGFB
48dbc-amp4410.9GFAP, S100B, VIM
4912-o-tetradecanoylphorbol 13-acetate4410.8VIM, ETS1, EGF, MUC1
50butyrate4410.6GFAP

GO Terms for genes affiliated with Meningioma

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16Gene Ontology
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Cellular components related to Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573712.1PTEN, VIM, S100B, PDGFB, MGEA5, NF2
2SWI/SNF complexGO:01651410.8SMARCE1, SMARCB1
3npBAF complexGO:07156410.7SMARCB1, SMARCE1
4nBAF complexGO:07156510.5SMARCE1, SMARCB1

Biological processes related to Meningioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828411.3S100B, PDGFB, EGF, ETS1, PTEN
2long-term synaptic potentiationGO:06029111.1PTEN, GFAP, S100B
3negative regulation of cell migrationGO:03033610.9PTEN, NF2, PDGFB
4Bergmann glial cell differentiationGO:06002010.9GFAP, VIM
5positive regulation of hyaluronan biosynthetic processGO:190012710.9EGF, PDGFB
6positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.8PTEN, EGF
7astrocyte developmentGO:01400210.7VIM, GFAP
8intermediate filament organizationGO:04510910.5GFAP, VIM

Molecular functions related to Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.7SMARCE1, S100B, PDGFB, AP1B1, EGF, NF2

Products for genes affiliated with Meningioma

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  • Antibodies
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Sources for Meningioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet