MCID: MNN012
MIFTS: 78

Meningioma malady

Genetic diseases, Rare diseases, Neuronal diseases, Endocrine diseases, Cancer diseases categories
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Summaries for Meningioma

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NIH Rare Diseases:42 Meningiomas are benign, slow-growing tumors, classified as brain tumors, but actually growing in the three protective membranes that surround the brain (meninges). sometimes they cause thickening or thinning of adjoining skull bones. meningiomas do not spread to other areas of the body. signs and symptoms vary according to the size and location of the tumor. the exact cause of this condition is unknown. last updated: 7/20/2011

MalaCards based summary: Meningioma, also known as intracranial meningioma, is related to spinal meningioma and secretory meningioma, and has symptoms including An important gene associated with Meningioma is MN1 (meningioma (disrupted in balanced translocation) 1), and among its related pathways are Glioblastoma Multiforme and PI-3K cascade. The drugs cytarabine and mifepristone and the compounds s 100 and fulvestrant have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related mouse phenotypes are tumorigenesis and vision/eye.

Disease Ontology:8 A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid "cap" cells of the arachnoid villi in the meninges.

Wikipedia:65 Meningiomas are a diverse set of tumors arising from the meninges, the membranous layers surrounding the... more...

Descriptions from OMIM:46 606190,607174

Aliases & Classifications for Meningioma

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Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Meningioma, Aliases & Descriptions:

Name: Meningioma 8 9 42 46 10 44 48 62
Intracranial Meningioma 8 44 62
Supratentorial Meningioma 8 62
Neoplasm of the Meninges 8 62
Familial Multiple Meningioma 48
 
Meningothelial Cell Neoplasm 62
Meningothelial Cell Tumor 8
Primary Meningeal Tumor 8
Meningeal Neoplasms 62
Meningeal Neoplasm 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
meningioma:
Prevalence: 1-9/100000; Age of onset: Variable
familial multiple meningioma:
Inheritance: Autosomal dominant; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:3565
MeSH34 D008577
NCIt39 C3229
MESH via Orphanet35 D008579
ICD10 via Orphanet26 D32.9
UMLS via Orphanet63 C0025286

Related Diseases for Meningioma

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Diseases in the Meningioma family:

Benign Meningioma Familial Meningioma
Meningioma, Sis-Related

Diseases related to Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 473)
idRelated DiseaseScoreTop Affiliating Genes
1spinal meningioma32.2NF2
2secretory meningioma31.8MUC1, VIM
3benign meningioma31.8EGFL6, NF2, PCNA, PGR, MKI67
4rhabdoid meningioma31.8GFAP, VIM
5fibrous meningioma31.5MUC1, NF2, EGFL6
6transitional meningioma31.4MUC1, NF2
7hemangiopericytoma31.3VIM, MUC1
8ependymoma31.3MKI67, GFAP, VIM, MUC1, NF2
9astrocytoma31.1MKI67, GFAP, PTEN, VIM, PCNA, PDGFB
10glioblastoma31.1PDGFB, PCNA, PTEN, GFAP, SMARCB1
11medulloblastoma31.1SMARCB1, GFAP, SUFU, PDGFB
12chordoma31.0GFAP, VIM, MUC1
13neurofibroma31.0VIM, MUC1, NF2
14hemangioblastoma31.0GFAP, MUC1
15choroid plexus papilloma30.9GFAP, MUC1
16neurilemmoma30.9SMARCB1, GFAP, VIM, MUC1, NF2
17adenocarcinoma30.9MKI67, PTEN, PGR, VIM, MUC1, PCNA
18perineurioma30.8VIM, MUC1
19retinoblastoma30.8MKI67, SMARCB1, GFAP, PCNA
20chondrosarcoma30.8MUC1, VIM
21sarcoma30.8MKI67, SMARCB1, VIM, MUC1, PDGFB, NF2
22glioblastoma multiforme30.8GFAP, PTEN, PDGFB
23papillary carcinoma30.7MKI67, PGR, MUC1
24paraganglioma30.7VIM
25dermatofibrosarcoma protuberans30.6VIM, MUC1, PDGFB
26melanoma30.6MKI67, PTEN, VIM, PCNA, PDGFB, NF2
27breast cancer30.6MKI67, PTEN, PGR, MUC1, PCNA, NF2
28gastrointestinal stromal tumor30.5NF2, PCNA, VIM, MKI67
29rhabdoid tumor30.5SMARCB1, VIM, MUC1
30retinal detachment30.5GFAP, PDGFB
31oligodendroglioma30.5PTEN, GFAP
32tuberous sclerosis30.5GFAP, PTEN, VIM
33giant cell glioblastoma30.3GFAP, PTEN
34gliosarcoma30.3GFAP, PTEN
35anaplastic ependymoma30.3GFAP, PTEN, MUC1, NF2
36adenosquamous carcinoma30.2PGR, MUC1
37colorectal cancer30.2MKI67, PTEN, PCNA, NF2
38malignant glioma30.1NF2, PDGFB, PCNA, VIM, PTEN, GFAP
39optic nerve sheath meningioma10.7
40clear cell meningioma10.7
41chordoid meningioma10.7
42cystadenocarcinoma10.7MUC1
43spinal cord ependymoma10.6NF2
44progesterone resistance10.6PGR
45mixed glioma10.6GFAP
46syringoma10.6GFAP, MUC1
47parasagittal meningioma10.6
48clear cell ependymoma10.6VIM, MUC1
49tanycytic ependymoma10.6GFAP, NF2
50malignant ependymoma10.6GFAP, NF2

Graphical network of the top 20 diseases related to Meningioma:



Diseases related to meningioma

Symptoms for Meningioma

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Symptoms by clinical synopsis from OMIM:

607174

Clinical features from OMIM:

606190,607174

HPO human phenotypes related to Meningioma:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 meningioma HP:0002858
3 adult onset HP:0003581
4 incomplete penetrance HP:0003829

Drugs & Therapeutics for Meningioma

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Drug clinical trials:

Search ClinicalTrials for Meningioma

Search NIH Clinical Center for Meningioma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Meningioma

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Anatomical Context for Meningioma

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MalaCards organs/tissues related to Meningioma:

32
Brain, Bone, Spinal cord, Pituitary, Endothelial, Lung, Breast, Thyroid, Pineal, Prostate, Liver, B cells, Lymph node, Skin, Myeloid, Temporal lobe, Eye, T cells, Bone marrow, Thymus, Cortex, Heart, Colon, Ovary, Placenta, Testis, Testes, Monocytes, Olfactory bulb, Tongue

Animal Models for Meningioma or affiliated genes

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MGI Mouse Phenotypes related to Meningioma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.4NF2, SMARCB1, MN1, PTEN, SUFU, PGR
2MP:000539110.3SMARCB1, GFAP, PTEN, VIM, MUC1, PDGFB
3MP:000537010.2THOC5, SMARCB1, PTEN, MUC1, PDGFB, NF2
4MP:000538010.2SMARCB1, PTEN, SUFU, PGR, VIM, PDGFB
5MP:000538110.2SMARCB1, GFAP, MN1, PTEN, SUFU, MUC1
6MP:001077110.1SUFU, PGR, MUC1, PDGFB, NF2, PTEN
7MP:000537610.1SMARCB1, GFAP, MN1, PTEN, SUFU, PGR
8MP:000538910.1SMARCB1, PTEN, PGR, VIM, PCNA, PDGFB
9MP:000538710.1THOC5, SMARCB1, GFAP, PTEN, PGR, VIM
10MP:001076810.0THOC5, SMARCB1, GFAP, MN1, PTEN, SUFU
11MP:000538510.0SMARCB1, GFAP, PTEN, SUFU, PGR, VIM
12MP:00053789.7SMARCB1, GFAP, PTEN, SUFU, VIM, PCNA

Publications for Meningioma

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Articles related to Meningioma:

(show top 50)    (show all 2191)
idTitleAuthorsYear
1
Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review. (24959273)
2014
2
Brain tissue adaptability to slow-growing tumors: case report of clivus meningioma. (24308252)
2013
3
A proposed scheme for the classification and surgical planning of falcine meningioma treatment. (23047062)
2012
4
Primary meningioma of the middle turbinate: a case report. (23076856)
2012
5
Mature posterior fossa teratoma mimicking infratentorial meningioma: a case report. (22030172)
2012
6
Analysis of the role of hMLH1 hypermethylation and microsatellite instability in meningioma progression. (22930430)
2012
7
Suprasellar meningioma presenting with an altitudinal field defect. (21873066)
2012
8
Transient global amnesia as a revealing sign of giant transtentorial meningioma: case report and review of the literature. (21629022)
2011
9
I+3I^1 integrin promotes radiation-induced migration of meningioma cells. (21455571)
2011
10
Meningial perineurioma: a benign peripheral nerve sheath tumor in a previously unrecognized central nervous system location, mimicking meningioma. (21831532)
2011
11
Rhabdoid meningioma presenting with subependymal and diffuse meningeal involvement but no mass lesion. (20800496)
2010
12
Rhabdoid meningioma: rapid intraoperative diagnosis on squash smears. (19941363)
2010
13
Hemangiopericytoma: collision with meningioma and recurrence. (20198500)
2010
14
NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth. (19451225)
2009
15
Metastasis of breast carcinoma to spinal meningioma. (19671116)
2009
16
Normal pressure hydrocephalus after radiosurgery for sphenoid ridge meningioma. (19013812)
2009
17
The microglial/macrophagic response at the tumour-brain border of invasive meningiomas. (19187060)
2009
18
uPA/uPAR downregulation inhibits radiation-induced migration, invasion and angiogenesis in IOMM-Lee meningioma cells and decreases tumor growth in vivo. (18949356)
2008
19
Tissue transgluaminase 2 expression in meningiomas. (18587533)
2008
20
The significance of immunohistochemical expression of Ki-67, p53, p21, and p16 in meningiomas tissue arrays. (18374497)
2008
21
Immunohistochemical expression of apoptosis regulating proteins and sex hormone receptors in meningiomas. (18021195)
2008
22
Progression of astrocytomas and meningiomas: an evaluation in vitro. (17227292)
2007
23
Chordoid meningioma: a report of two cases. (17517194)
2007
24
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. (17894293)
2007
25
Rosai-Dorfman disease mimicking a sphenoid wing meningioma. (15805669)
2005
26
Cerebellar and multiple spinal hemangioblastomas and intraventricular meningioma managed with subtotal resection and external beam radiotherapy; report of a case with literature review. (17357198)
2005
27
Involution of retinochoroidal shunt vessel after radiotherapy for optic nerve sheath meningioma. (15005588)
2004
28
Immunohistochemical study of anaplastic meningioma with special reference to the phenotypic change of intermediate filament protein. (12913843)
2003
29
Case report: microcystic meningioma in a 58-year-old man with multicystic meningioangiomatosis. (12662324)
2003
30
Telomerase activity and expression of the telomerase catalytic subunit, hTERT, in meningioma progression. (10794298)
2000
31
Multiple intracranial and intraspinal meningiomas in the neurocristopathy (phacomatosis) type of neurofibromatosis]. (11378907)
2000
32
Premeatal and retromeatal cerebellopontine angle meningioma. Two distinct clinical entities. (10392201)
1999
33
Intraparenchymal clear cell meningioma of the brainstem in a 2-year-old child. Case report and literature review. (9693326)
1998
34
Preservation of residual vision 2 years after stereotactic radiosurgery for a presumed optic nerve sheath meningioma. (9621268)
1998
35
Lipomatous secretory meningioma: case report and review of the literature. (9833895)
1998
36
Olfactory groove meningioma with paranasal sinus and nasal cavity extension: removal by combined subfrontal and nasal approach. (9819682)
1998
37
Hormones, radiosurgery and virtual reality: new aspects of meningioma management. (9398976)
1997
38
Secretory meningioma with severe perifocal edema--case report. (9301199)
1997
39
Case report: intraventricular meningioma with cerebellopontine angle and drop metastases. (7795983)
1995
40
Role of CD44 in the invasiveness of glioblastoma multiforme and the noninvasiveness of meningioma: an immunohistochemistry study. (7557949)
1995
41
Clear cell meningioma. A clinicopathologic study of a potentially aggressive variant of meningioma. (7726360)
1995
42
Somatic mutations in the neurofibromatosis type 2 gene in sporadic meningiomas. (7868131)
1995
43
Radiation-induced meningioma. (8608584)
1995
44
Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas. (8162072)
1994
45
Secretory meningioma: a case report with immunohistochemical and ultrastructural study. (8220795)
1993
46
Combined supratentorial and infratentorial approach to large pineal-region meningioma. (1536024)
1992
47
Cranioplasty of an extremely large cranial defect caused by transitional meningioma with a knitted polypropylen-polyester prothesis "Codubix". (1776518)
1991
48
Primary optic nerve sheath meningioma. (2611192)
1989
49
The value of enhanced "dynamic" computed tomography in localizing a spinal juxtamedullary meningioma. Enhanced dynamic CT in localizing a spinal meningioma. (3614634)
1987
50
Extradural multiple spinal meningioma. Literature review a case report. (3748265)
1986

Variations for Meningioma

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Clinvar genetic disease variations for Meningioma:

6
id Gene Name Type Significance SNP ID Assembly Location
1SUFUNM_016169.3(SUFU): c.367C> T (p.Arg123Cys)single nucleotide variantrisk factorrs202247756GRCh37Chr 10, 104309776: 104309776
2SMARCE1NM_003079.4(SMARCE1): c.715C> T (p.Arg239Ter)single nucleotide variantrisk factorrs397509405GRCh37Chr 17, 38787945: 38787945
3SMARCE1NM_003079.4(SMARCE1): c.237+2T> Csingle nucleotide variantrisk factorrs397509406GRCh37Chr 17, 38793742: 38793742
4SMARCE1NM_003079.4(SMARCE1): c.311G> A (p.Trp104Ter)single nucleotide variantrisk factorrs397509407GRCh37Chr 17, 38792705: 38792705
5SMARCE1NM_003079.4(SMARCE1): c.572dupC (p.Ala192Serfs)duplicationrisk factorrs397509408GRCh37Chr 17, 38788588: 38788589

Expression for genes affiliated with Meningioma

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Expression patterns in normal tissues for genes affiliated with Meningioma

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Pathways for genes affiliated with Meningioma

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Compounds for genes affiliated with Meningioma

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Compounds related to Meningioma according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1s 1004410.7MUC1, VIM, GFAP
2fulvestrant44 50 28 1113.6MKI67, PGR, PCNA
3eosin4410.6GFAP, VIM, MUC1, PCNA
4reticulin4410.6GFAP, VIM, MUC1, PCNA
5b 7234410.6PCNA, MUC1, VIM
6tgf beta14410.6MKI67, PTEN, VIM, PDGFB
7silver4410.6PDGFB, PCNA, GFAP, MKI67
8biotin44 24 1112.6PCNA, MUC1, VIM, MKI67
9trastuzumab44 50 1112.6MUC1, PGR, PTEN
10dutp4410.6PCNA, GFAP, MKI67
11cytarabine44 50 1112.6PCNA, MUC1, VIM, GFAP
12deoxyribonucleic acid4410.6PTEN, PCNA, NF2
13bromodeoxyuridine4410.6MKI67, GFAP, VIM, PCNA, PDGFB
14folate4410.6MKI67, PGR, VIM, MUC1
15cyclophosphamide44 50 1112.6MKI67, PTEN, PGR, PCNA
165fluorouracil4410.6MKI67, PTEN, PGR, MUC1, PCNA
17glycogen44 2411.5MKI67, GFAP, PTEN, VIM, MUC1
185-aza-2deoxycytidine4410.5PTEN, PGR, VIM, PCNA
19formaldehyde44 2411.5MKI67, GFAP, VIM, MUC1, PCNA
20methotrexate50 44 1112.5MKI67, PGR, VIM, MUC1, PCNA
21hematoxylin4410.5MKI67, GFAP, PTEN, VIM, MUC1, PCNA
22cycloheximide4410.5MKI67, GFAP, PTEN, PGR, VIM, PDGFB
23tamoxifen44 50 28 1113.5MKI67, PTEN, PGR, VIM, MUC1, PCNA
24agar4410.5GFAP, PTEN, PGR, VIM, MUC1, PDGFB
25paclitaxel44 50 1112.5MKI67, GFAP, PTEN, PGR, VIM, PCNA
26procollagen4410.5PDGFB, PCNA, VIM
27genistein44 28 61 2 24 1115.5GFAP, PTEN, PGR, VIM, PCNA
28progestin4410.5MUC1, VIM, PGR
29estradiol44 24 1112.5MKI67, GFAP, PTEN, PGR, VIM, MUC1
30thymidine44 2411.5MKI67, GFAP, MUC1, PCNA, PDGFB
31cisplatin44 50 61 1113.4MKI67, GFAP, PTEN, MUC1, PCNA
32ethanol44 50 24 1113.4MKI67, GFAP, PTEN, MUC1
33dexamethasone44 50 28 1113.4GFAP, PGR, VIM, MUC1, PCNA, PDGFB
34aspartate4410.4PCNA, VIM, PGR, PTEN, GFAP
35testosterone44 61 24 1113.4MKI67, GFAP, PTEN, PGR, VIM, MUC1
36butyrate4410.4GFAP, VIM, MUC1, PCNA
37cysteine4410.4GFAP, PTEN, PGR, VIM, MUC1, PCNA
38polyethylene glycol4410.4GFAP, MUC1, PCNA
39vegf4410.4MKI67, GFAP, PTEN, PGR, VIM, MUC1
40mifepristone44 28 61 1113.4MUC1, PGR, MKI67
41estrogen4410.4MKI67, GFAP, PTEN, PGR, VIM, MUC1
42retinoic acid44 2411.4MKI67, GFAP, MN1, PTEN, PGR, VIM
43paraffin4410.4NF2, MKI67, GFAP, PTEN, PGR, VIM
44progesterone44 28 61 24 1114.4MKI67, GFAP, PTEN, PGR, VIM, MUC1
45gemcitabine44 50 1112.3PCNA, MUC1, PTEN
46serine4410.3MKI67, GFAP, PTEN, VIM, MUC1, PDGFB
47norcantharidin4410.3PCNA, MKI67
48azathioprine44 2 50 1113.3VIM, PCNA, PDGFB
49lipid4410.0MKI67, GFAP, PTEN, VIM, MUC1, PDGFB
50doxorubicin44 50 1111.9VIM, PGR, PTEN, MKI67

GO Terms for genes affiliated with Meningioma

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Cellular components related to Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:00573010.0MKI67, SMARCB1, PTEN, SUFU, PCNA, NF2
2cytoplasmGO:0057379.5NF2, MGEA5, THOC5, MKI67, GFAP, PTEN

Biological processes related to Meningioma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:06002010.5VIM, GFAP
2negative regulation of cell migrationGO:03033610.5NF2, PDGFB, PTEN
3astrocyte developmentGO:01400210.5GFAP, VIM
4intermediate filament organizationGO:04510910.5VIM, GFAP
5platelet-derived growth factor receptor signaling pathwayGO:04800810.4PDGFB, PTEN
6phosphatidylinositol-mediated signalingGO:04801510.4PTEN, PCNA, PDGFB
7heart developmentGO:00750710.3PDGFB, PCNA, PTEN
8long-term synaptic potentiationGO:06029110.3GFAP, PTEN
9positive regulation of glucose importGO:04632610.1CLTCL1, MGEA5

Molecular functions related to Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor bindingGO:00516110.4PDGFB, PTEN
2protein bindingGO:0055159.4NF2, THOC5, MKI67, SMARCB1, PTEN, AP1B1

Products for genes affiliated with Meningioma

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  • Antibodies
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Sources for Meningioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet