MCID: MNN012
MIFTS: 67

Meningioma malady

Neuronal, Endocrine, Cancer categories

Summaries for Meningioma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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NIH Rare Diseases:43 Meningiomas are benign, slow-growing tumors, classified as brain tumors, but actually growing in the three protective membranes that surround the brain (meninges). sometimes they cause thickening or thinning of adjoining skull bones. meningiomas do not spread to other areas of the body. signs and symptoms vary according to the size and location of the tumor. the exact cause of this condition is unknown. last updated: 7/20/2011

MalaCards: Meningioma, also known as intracranial meningioma, is related to spinal meningioma and benign meningioma. An important gene associated with Meningioma is MN1 (meningioma (disrupted in balanced translocation) 1), and among its related pathways are Rho Family GTPases and PIP3 activates AKT signaling. The drugs mifepristone and cytarabine and the compounds progesterone and vegf have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and immune system.

Disease Ontology:8 A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid "cap" cells of the arachnoid villi in the meninges.

Wikipedia:64 Meningiomas are a diverse set of tumors arising from the meninges, the membranous layers surrounding the... more...

Description from OMIM:47 606190,607174

Aliases & Classifications for Meningioma

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal, Endocrine


Characteristics (Orphanet epidemiological data):

49
meningioma:
Prevalence: 1-9/100000
familial multiple meningioma:
Inheritance: Autosomal dominant; Age of onset: Variable


Aliases & Descriptions:

meningioma 8 9 43 47 10 45 49 61
intracranial meningioma 8 45 61
supratentorial meningioma 8 61
meningioma, benign, no icd-o subtype 8
meningothelial cell neoplasm 61
familial multiple meningioma 49
meningothelial cell tumor 8
neoplasm of the meninges 8
primary meningeal tumor 8
neoplasm of meninges 8
meningeal neoplasms 61
meningeal neoplasm 8
meningioma nos 8
meningiomas 8


External Ids:

Disease Ontology8 DOID:3565
MeSH35 D008577
NCIt40 C3229
ICD10 via Orphanet26 D32.9
SNOMED-CT via Orphanet58 19453003
UMLS via Orphanet62 C0025286
MESH via Orphanet36 D008579

Related Diseases for Meningioma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Meningioma family:

benign meningioma familial meningioma
meningioma, sis-related

Diseases related to Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 402)
idRelated DiseaseScoreTop Affiliating Genes
1spinal meningioma31.2SMARCE1, NF2
2benign meningioma31.0NF2, ETS1, EGFL6, PGR
3secretory meningioma30.8MUC1, VIM
4fibrous meningioma30.7EGFL6, MUC1, NF2, S100B
5neurofibromatosis30.6NF2
6adenoma30.6MUC1, ETS1
7astrocytoma30.6GFAP, PTEN, VIM, ETS1, NF2, S100B
8transitional meningioma30.4MUC1, NF2
9ependymoma30.4VIM, S100B, NF2, MUC1, GFAP
10adenocarcinoma30.4VIM, PGR, ETS1, EGF, NF2, PTEN
11acute leukemia30.3SMARCB1, ETS1
12basal cell carcinoma30.2SUFU
13lymphangioleiomyomatosis30.2PGR
14teratoma30.1SMARCB1, GFAP
15fibrous histiocytoma30.1VIM, S100B
16choroid plexus papilloma30.0GFAP, MUC1, S100B
17pilocytic astrocytoma30.0S100B, GFAP, PTEN
18renal clear cell carcinoma30.0PTEN, VIM, MUC1
19anaplastic astrocytoma30.0PTEN, GFAP
20papillary carcinoma29.9MUC1, ETS1, PGR
21gliosarcoma29.9GFAP, PTEN
22paraganglioma29.9S100B, GFAP
23thyroid cancer29.9ETS1, EGF, PTEN
24ganglioglioma29.9GFAP, S100B
25anaplastic ependymoma29.6MUC1, NF2, S100B, PTEN, GFAP
26dermatofibrosarcoma protuberans29.6VIM, PDGFB, MUC1, S100B
27tuberous sclerosis29.6VIM, S100B, GFAP, PTEN
28gastrointestinal stromal tumor29.6NF2, VIM, S100B
29rhabdoid tumor29.6SMARCB1, MUC1, VIM
30adenoid cystic carcinoma29.6S100B, MUC1, VIM
31clear cell ependymoma29.6MUC1, VIM
32giant cell glioblastoma29.6PTEN, GFAP
33myxopapillary ependymoma29.6S100B, GFAP
34dermatofibrosarcoma29.6PDGFB
35brain cancer29.6GFAP
36colorectal cancer29.6PTEN, EGF, NF2, ETS1
37optic nerve sheath meningioma10.7
38brain meningioma10.7
39chordoid meningioma10.7
40parasagittal meningioma10.6
41skull base meningioma10.6
42radiation induced meningioma10.6
43cerebellopontine angle meningioma10.6
44olfactory groove meningioma10.5
45suprasellar meningioma10.5
46microcystic meningioma10.5
47brain edema10.5
48petroclival meningioma10.5
49tuberculum sellae meningioma10.5
50meningothelial meningioma10.5

Graphical network of the top 20 diseases related to Meningioma:



Diseases related to meningioma

Clinical Features for Meningioma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

606190,607174

Clinical synopsis from OMIM:

607174

Drugs & Therapeutics for Meningioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Meningioma

Drug clinical trials:

Search ClinicalTrials for Meningioma

Search NIH Clinical Center for Meningioma

Search CenterWatch for Meningioma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Meningioma

Anatomical Context for Meningioma

Animal Models for Meningioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Meningioma

Sources:
51PubMed
See all sources

Articles related to Meningioma:

(show top 50)    (show all 2130)
idTitleAuthorsYear
1
Successful intra-arterial thrombolysis in a patient with an intracranial meningioma. (23830958)
2013
2
5-Aminolevulinic-Acid-Induced Protoporphyrin IX Fluorescence in Meningioma: Qualitative and Quantitative Measurements In Vivo. (23887194)
2013
3
Skull base secretory meningioma. Value of histological and immunohistochemical findings for peritumoral brain edema formation. (23645307)
2013
4
Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas. (24098347)
2013
5
Frontal meningioma mimicking relapse of schizophrenia. (24220131)
2013
6
Primary meningioma of the middle turbinate: a case report. (23076856)
2012
7
Suprasellar meningioma presenting with an altitudinal field defect. (21873066)
2012
8
Microdeletion del(22)(q12.2) encompassing the facial development-associated gene, MN1 (meningioma 1) in a child with Pierre-Robin sequence (including cleft palate) and neurofibromatosis 2 (NF2): a case report and review of the literature. (22436304)
2012
9
Standard-fractionated radiotherapy for optic nerve sheath meningioma: visual outcome is predicted by mean eye dose. (21640493)
2012
10
New insights into meningioma: from genetics to trials. (22820412)
2012
11
Unusual growth pattern of a meningioma. (22754728)
2012
12
Occupational exposure to chlorinated solvents and risks of glioma and meningioma in adults. (22864249)
2012
13
An endoscopic endonsal transethmoidal approach to olfactory groove meningioma. (22076822)
2011
14
Hormonal effect on meningioma growth. (22152568)
2011
15
Isolated intracranial Rosai-Dorfman disease mimicking meningioma in a child: a case report and review of the literature. (21697409)
2011
16
Expression of podoplanin and calretinin in meningioma: an immunohistochemical study. (20425044)
2010
17
Multiple dural lesions mimicking meningiomas in patients with CCM3/PDCD10 mutations. (19506228)
2009
18
An unusual case of clear cell meningioma. (20160375)
2009
19
Primary jugular foramen meningioma. (18090094)
2008
20
Cytologic findings of rhabdoid meningioma in cerebrospinal fluid. (18323288)
2008
21
Clinical without histopathological manifestations of inflammation in a patient with primary intraorbital optic nerve sheath meningioma. (17548993)
2007
22
Histological classification and molecular genetics of meningiomas. (17110285)
2006
23
Microsurgical excision of the large or giant cerebellopontine angle meningioma. (16547882)
2006
24
Pyrogenic cytokine interleukin-6 expression by a chordoid meningioma in an adult with a systemic inflammatory syndrome. Case report and review of the literature. (16235690)
2005
25
Molecular genetics of meningiomas. (16398473)
2005
26
Management of sight-threatening optic nerve sheath meningioma with fractionated stereotactic radiotherapy. (15807820)
2005
27
Results of spinal meningioma surgery in patients with severe preoperative neurological deficits. (15959827)
2005
28
Side effects related to cancer treatment: CASE 3. Primary cerebral lymphoma after radiotherapy for recurrent meningioma. (16293883)
2005
29
Invasive meningioma is associated with a low expression of E-cadherin and beta-catenin. (15696778)
2005
30
Should patients with lymphangioleiomyomatosis undergo screening for meningioma? (15516686)
2004
31
Expression of cytokeratin by malignant meningiomas: diagnostic pitfall of cytokeratin to separate malignant meningiomas from metastatic carcinoma. (15133478)
2004
32
Immunohistochemical study of anaplastic meningioma with special reference to the phenotypic change of intermediate filament protein. (12913843)
2003
33
Prognostic significance of cyclin a expression in meningiomas. (12610350)
2003
34
Expression of the inhibitor of apoptosis protein survivin in benign meningiomas. (12706880)
2003
35
Progesterone receptor, bc1-2 and bax expression in meningiomas. (11949825)
2002
36
Meningiomas in lymphangioleiomyomatosis. (11597290)
2001
37
Clear-cell meningioma in a 22-month-old male: a case report and literature review. (11423779)
2001
38
Fibrous meningioma with tyrosine-rich crystals. (10582272)
1999
39
Increased proliferative activity due to necroses induced by pre-operative embolization in benign meningiomas. (10066099)
1998
40
Quantitative analysis of neurofibromatosis type 2 gene transcripts in meningiomas supports the concept of distinct molecular variants. (9426397)
1997
41
In vitro chemotherapy of steroid receptor positive human meningioma low-passage primary cultures with nitrosourea-methionine-steroid conjugates. (8937791)
1996
42
Radiation-induced meningioma evaluated with positron emission tomography with fludeoxyglucose F 18. (8733970)
1996
43
Cervical dystonia due to a frontal meningioma. (8723157)
1996
44
Primary intrapulmonary meningiomas. A clinicopathologic and immunohistochemical study of ten cases. (8941002)
1996
45
Proliferating cell nuclear antigen (PCNA) and nucleolar organizer regions (NORs) in benign, atypical and malignant meningiomas. (8867694)
1995
46
Immunohistochemical study of estrogen receptor-related antigen, progesterone and estrogen receptors in human intracranial meningiomas. (8033047)
1994
47
Associated spinal meningioma and neurinoma. A case report. (3630794)
1987
48
Cerebellopontine angle meningioma presenting as subarachnoid haemorrhage. (1085038)
1976
49
An unusual clivus meningioma. (5112260)
1971
50
Middle cranial fossa meningioma. Causing unilateral loss of visual acuity. (5931276)
1966

Genetic Variations for Meningioma

Expression for genes affiliated with Meningioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Meningioma

Search GEO for disease gene expression data for Meningioma.

Pathways for genes affiliated with Meningioma

Sources:
52QIAGEN, 54Reactome, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Meningioma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Meningioma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1progesterone45 60 29 11 2416.4VIM, S100B, PDGFB, EGF, NF2, MUC1
2vegf4512.3VIM, S100B, PDGFB, EGF, MUC1, ETS1
3estrogen4512.3VIM, S100B, PDGFB, EGF, MUC1, ETS1
4retinoic acid45 2413.3VIM, S100B, EGF, MN1, MUC1, ETS1
5cysteine4512.3VIM, S100B, EGF, NF2, MUC1, ETS1
6serine4512.2VIM, S100B, PDGFB, EGF, NF2, MUC1
7agar4512.1PTEN, VIM, PDGFB, EGF, NF2, MUC1
8paraffin4512.1VIM, S100B, PDGFB, NF2, MUC1, PGR
9estradiol45 11 2414.0VIM, EGF, MUC1, ETS1, PGR, GFAP
10cyclic amp45 2412.9VIM, S100B, EGF, MUC1, ETS1, GFAP
11testosterone45 60 11 2414.9VIM, S100B, EGF, MUC1, PGR, GFAP
12tyrosine4511.9S100B, PDGFB, EGF, NF2, MUC1, ETS1
13threonine4511.9S100B, EGF, NF2, MUC1, ETS1, GFAP
14thymidine45 2412.8S100B, PDGFB, EGF, MUC1, ETS1, GFAP
15hematoxylin4511.7VIM, S100B, MUC1, GFAP, PTEN
16paclitaxel45 50 1113.7S100B, EGF, PGR, GFAP, PTEN
17bromodeoxyuridine4511.6VIM, S100B, PDGFB, EGF, GFAP
18tgf beta14511.6VIM, PDGFB, EGF, ETS1, PTEN
19alanine4511.6VIM, S100B, ETS1, PGR, GFAP, PTEN
20matrigel4511.6VIM, EGF, MUC1, ETS1, GFAP
21tamoxifen45 50 29 1114.6VIM, EGF, MUC1, PGR, PTEN
22pd 98,0594511.6PDGFB, EGF, ETS1, GFAP, PTEN
23glycogen45 2412.6VIM, S100B, MUC1, GFAP, PTEN
24forskolin45 50 1113.5VIM, S100B, EGF, MUC1, GFAP
25eosin4511.5VIM, S100B, MUC1, GFAP
26genistein45 29 60 2 11 2416.5PTEN, GFAP, PGR, EGF, VIM
27s 1004511.5VIM, S100B, MUC1, GFAP
28reticulin4511.5VIM, S100B, MUC1, GFAP
29trastuzumab45 50 1113.5PTEN, PGR, MUC1, EGF
304-hydroxytamoxifen4511.5VIM, S100B, EGF, PGR
31progestin4511.5VIM, EGF, MUC1, PGR
32dihydrotestosterone45 29 11 2414.4PGR, MUC1, EGF, VIM
33formaldehyde45 2412.4GFAP, MUC1, S100B, VIM
34aspartate4511.4VIM, S100B, PGR, GFAP, PTEN
35adenylate4511.3VIM, S100B, EGF, PGR, GFAP
36dexamethasone45 50 29 1114.3GFAP, PDGFB, S100B
37mucicarmine4511.3VIM, S100B, MUC1
38chloramphenicol45 2 1113.3MUC1, PDGFB, S100B
39oxygen45 2412.3S100B, PDGFB, MUC1, ETS1, GFAP, PTEN
405fluorouracil4511.3EGF, MUC1, PGR, PTEN
41b 7234511.3MUC1, S100B, VIM
42gaba4511.3VIM, S100B, PGR, GFAP
43glutamine4511.1EGF, GFAP
44panitumumab45 50 1113.0PTEN, EGF
45orcein4511.0S100B, VIM
46dbc-amp4511.0VIM, S100B, GFAP
47cycloheximide4511.0PDGFB
48gefitinib45 50 1112.9VIM, EGF, PTEN
4912-o-tetradecanoylphorbol 13-acetate4510.8ETS1, MUC1, EGF, VIM
50butyrate4510.6GFAP

GO Terms for genes affiliated with Meningioma

Sources:
16Gene Ontology
See all sources

Cellular components related to Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573712.1PTEN, VIM, S100B, PDGFB, MGEA5, NF2
2SWI/SNF complexGO:01651410.8SMARCE1, SMARCB1
3npBAF complexGO:07156410.7SMARCB1, SMARCE1
4nBAF complexGO:07156510.5SMARCE1, SMARCB1

Biological processes related to Meningioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828411.3S100B, PDGFB, EGF, ETS1, PTEN
2long-term synaptic potentiationGO:06029111.1PTEN, GFAP, S100B
3negative regulation of cell migrationGO:03033610.9PTEN, NF2, PDGFB
4Bergmann glial cell differentiationGO:06002010.9GFAP, VIM
5positive regulation of hyaluronan biosynthetic processGO:190012710.9EGF, PDGFB
6positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.8PTEN, EGF
7astrocyte developmentGO:01400210.7VIM, GFAP
8intermediate filament organizationGO:04510910.5GFAP, VIM

Molecular functions related to Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.7SMARCE1, S100B, PDGFB, AP1B1, EGF, NF2

Products for genes affiliated with Meningioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Meningioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet