Meningioma malady

NIH Rare Diseases: Meningiomas are benign, slow-growing tumors, classified as brain tumors, but actually growing in the three protective membranes that surround the brain (meninges). Sometimes they cause thickening or thinning of adjoining skull bones. Meningiomas do not spread to other areas of the body. Signs and symptoms vary according to the size and location of the tumor. The exact cause of this condition is unknown.³⁰

MalaCards: Meningioma, also known as intracranial meningioma, is related to leukemia and carcinoma. An important gene associated with Meningioma is MN1 (meningioma (disrupted in balanced translocation) 1), and among its related pathways are ERK Signaling and Epithelial Adherens Junctions. The drugs prednisone and prednisolone tebutate and the compounds cysteine and calcium have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and liver, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Disease Ontology: A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid "cap" cells of the arachnoid villi in the meninges.⁶

Wikipedia: Meningiomas are a diverse set of tumors arising from the meninges, the membranous layers surrounding the...⁴⁴ more...

OMIM: 607174

Aliases & Descriptions:

meningioma 6 7 30 8 33 32 43 intracranial meningioma 6 8 32 43 supratentorial meningioma 6 43 meningioma, benign, no icd-o subtype (morphologic abnormality) 6 meningioma nos (morphologic abnormality) 6 meningiomas (morphologic abnormality) 6 intracranial meningioma (disorder) 6 meningothelial cell neoplasm 43

meningothelial cell tumor 6 neoplasm of the meninges 6 primary meningeal tumor 6 neoplasm of meninges 6 meningeal neoplasms 43 meningeal neoplasm 6 meningioma nos 6 neoplasms 43

Diseases related to meningioma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1660)

id	Related Disease	Score	Top Affiliating Genes
1	leukemia	71.6	ZNF76, PIK3CG, WDHD1, RFC1, NCAM1, NCF2
2	carcinoma	70.6	PIK3CG, RFC1, NCAM1, NCF2, NCL, NCOA2
3	pancreatitis	59.0	PIK3CG, NCAM1, NCF2, NCL, NCOA3, RET
4	prostatitis	58.3	PIK3CG, SH2D2A, RFC1, NCAM1, NCL, NCOA2
5	adenocarcinoma	55.5	PIK3CG, NCAM1, NCL, NCOA3, RET, REV1
6	melanoma	52.7	PIK3CG, NCAM1, NCL, NCOA2, NCOA3, RET
7	neuronitis	51.8	PIK3CG, NCAM1, NCF2, NCF4, NCL, NCOA2
8	adenoma	50.1	NCAM1, NCF2, NCOA2, NCOA3, RET, SFRP1
9	hepatocellular carcinoma	48.1	PIK3CG, NCAM1, NCL, NCOA3, RET, SFRP1
10	thyroiditis	47.9	PIK3CG, RFC1, NCAM1, NCOA2, NCOA3, RET
11	breast carcinoma	47.9	PIK3CG, NCL, NCOA2, NCOA3, RDX, SFRP1
12	sarcoma	47.4	PIK3CG, NCAM1, NCOA3, RET, PCNA, RB1
13	astrocytoma	46.7	PIK3CG, NCAM1, RET, PCNA, RB1, SETD2
14	cervicitis	46.0	PIK3CG, RFC1, NCL, RECQL4, RET, REV1
15	cerebritis	44.8	PIK3CG, NCAM1, PDCD10, PCNA, SELE, SELP
16	gastric cancer	44.7	PIK3CG, RFC1, NCL, NCOA3, SFRP1, PCNA
17	lung carcinoma	44.0	PIK3CG, NCAM1, RDX, PCNA, RB1, NBN
18	esophagitis	43.4	PIK3CG, WDHD1, NCAM1, NCOA3, RET, REV1
19	ovarian carcinoma	42.8	PIK3CG, NCOA3, REV1, PCNA, RB1, SETD2
20	anaplastic meningioma	42.0	PCNA, RB1, VIM, VEGFA, KDR, LEPREL4
21	hypoxia	41.5	PIK3CG, NCOA2, RET, SFRP1, PCNA, RB1
22	pituitary adenoma	40.4	NCAM1, RET, PCNA, RB1, VIM, VIPR1
23	benign meningioma	40.0	PCNA, VIM, BIRC5, MUC1, MLPH, MKI67
24	thyroid cancer	39.5	PIK3CG, RFC1, NCOA3, RET, PCNA, NBN
25	ependymoma	39.1	NCAM1, NCL, RB1, VIM, BRCA2, VEGFA
26	osteosarcoma	39.1	PIK3CG, RFC1, RECQL4, PCNA, RB1, SERPINC1
27	fibrosis	39.0	PIK3CG, NCF2, NCOA3, PCNA, SELE, SELP
28	glioblastoma	38.8	PIK3CG, RB1, SETD2, VHL, VEGFA, MYCN
29	renal cell carcinoma	38.7	RET, SFRP1, PCNA, GCNT2, SELP, SETD2
30	myeloid leukemia	38.4	PIK3CG, NCAM1, NCL, NCOA2, NCOA3, SFRP1
31	medulloblastoma	38.0	PIK3CG, NCAM1, SFRP1, PCNA, RB1, NBN
32	esophageal cancer	37.6	PIK3CG, SFRP1, PCNA, RB1, SERPINB3, SERPINA3
33	papilloma	37.4	RET, PCNA, RB1, SERPINB3, SERPINB2, VIM
34	cervical cancer	37.3	PIK3CG, RFC1, NCL, RECQL4, SFRP1, PCNA
35	atherosclerosis	37.3	PIK3CG, NCF2, PCNA, SELE, SELP, SELPLG
36	retinoblastoma	37.0	PIK3CG, RFC1, NCAM1, NCL, PCNA, RB1
37	thyroid carcinoma	36.9	PIK3CG, RECQL4, RET, RDX, PCNA, RB1
38	epithelial ovarian cancer	36.8	PIK3CG, NCOA3, RB1, NBN, SERPINB2, SERPINE1
39	leiomyoma	36.4	SFRP1, PCNA, SERPINB3, SERPINE1, VIM, BRCA2
40	hemangiopericytoma	36.2	NCAM1, RB1, VIM, VEGFA, KDR, MUC1
41	meningitis	36.2	PIK3CG, NCAM1, PCNA, RB1, SELE, VIM
42	colon carcinoma	36.2	PIK3CG, NCAM1, NCL, SELE, SELP, SELPLG
43	laryngitis	36.1	RECQL4, PCNA, RB1, SERPINB3, SETD2, SERPINB2
44	cervical carcinoma	35.9	PIK3CG, RECQL4, REV1, PCNA, RB1, SERPINB3
45	peritonitis	35.9	RET, PCNA, SELE, SELP, SELPLG, SERPINC1
46	secretory meningioma	35.7	VIM, MUC1, LAMB1, CEACAM5, CEACAM7, FN1
47	wilms tumor	35.6	NCAM1, RET, PCNA, SETD2, VIM, BRCA2
48	choroiditis	35.3	PIK3CG, NCAM1, PCNA, SELE, SETD2, SERPINE1
49	gastrointestinal stromal tumor	35.2	PIK3CG, NCAM1, PCNA, VIM, VEGFA, VCAN
50	cerebral meningioma	35.1	LIFR, IL6, IGF1, ESR1, DRD1, EGF

Clinical features from OMIM: 607174

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cytarabine, cytarabine liposome, dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, mifepristone, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

MalaCards organs/tissues related to meningioma:

²²

MGI Mouse Phenotypes related to meningioma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CG, NCOA3, RET, RDX, SFRP1, GCNT2
2	growth/size phenotype	MP:0005378	INF	PIK3CG, NCOA2, NCOA3, PDCD10, RECQL4, RET
3	endocrine/exocrine gland phenotype	MP:0005379	INF	NCOA2, RET, NBN, VIPR1, BRCA2, BMPR1A
4	renal/urinary system phenotype	MP:0005367	INF	NCOA3, RET, GCNT2, SELP, SELPLG, VHL
5	mortality/aging	MP:0010768	INF	NCAM1, NCF4, PDCD10, RECQL4, RET, REV1
6	nervous system phenotype	MP:0003631	INF	PDCD10, CNTNAP1, RDX, SFRP1, RB1, NBN
7	cardiovascular system phenotype	MP:0005385	INF	PIK3CG, PDCD10, RET, SFRP1, RB1, SELE
8	behavior/neurological phenotype	MP:0005386	INF	NCAM1, NCOA2, NCOA3, PDCD10, CNTNAP1, RDX
9	muscle phenotype	MP:0005369	INF	PIK3CG, NCOA3, PDCD10, RET, CNTNAP1, RB1
10	immune system phenotype	MP:0005387	20.0	SH2D2A, NCF4, NCOA2, NCOA3, PDCD10, RECQL4
11	hematopoietic system phenotype	MP:0005397	19.3	SH2D2A, PDCD10, RECQL4, REV1, SFRP1, PCNA
12	skeleton phenotype	MP:0005390	16.3	PIK3CG, SFRP1, RB1, NBL1, SEMA3A, NAB2
13	tumorigenesis	MP:0002006	15.7	NCOA3, PDCD10, RECQL4, RET, RB1, NBN
14	craniofacial phenotype	MP:0005382	14.4	NCOA3, PDCD10, RECQL4, NBN, MYCN, BMP4
15	respiratory system phenotype	MP:0005388	13.9	RET, SELP, SEMA3A, NAB2, MYCN, BMPR1A
16	pigmentation phenotype	MP:0001186	12.0	RECQL4, RB1, SERPINC1, MYC, BMPR1A, RAC1
17	adipose tissue phenotype	MP:0005375	11.5	NCOA3, SFRP1, RB1, SERPINE1, MYC, MYD88
18	other phenotype	MP:0005395	11.4	RARA, KDR, CDKN2A, FN1, IL11RA, APOA2
19	integument phenotype	MP:0010771	INF	PIK3CG, NCOA2, NCOA3, PDCD10, RECQL4, GCNT2
20	embryogenesis phenotype	MP:0005380	INF	NCOA2, NCOA3, PDCD10, RECQL4, RET, SFRP1
21	normal phenotype	MP:0002873	INF	PDCD10, RET, REV1, NBL1, SELE, SERPING1
22	vision/eye phenotype	MP:0005391	INF	NCAM1, PDCD10, RECQL4, CNTNAP1, RB1, SELE
23	reproductive system phenotype	MP:0005389	INF	NCOA2, NCOA3, RET, CNTNAP1, NBN, NAB2
24	limbs/digits/tail phenotype	MP:0005371	INF	RECQL4, RET, SFRP1, RB1, BRCA2, VHL
25	liver/biliary system phenotype	MP:0005370	INF	NCOA3, RDX, SERPINC1, VHL, VEGFA, MYCN
26	hearing/vestibular/ear phenotype	MP:0005377	INF	NCOA3, RDX, RB1, MYC, MYD88, BMP4
27	cellular phenotype	MP:0005384	INF	PIK3CG, SH2D2A, NCAM1, NCOA3, PDCD10, RECQL4
28	no phenotypic analysis	MP:0003012	INF	NCOA2, RET, SFRP1, PCNA, RB1, SEMA3A
29	digestive/alimentary phenotype	MP:0005381	INF	NCOA3, RECQL4, RET, RB1, VIPR1, BRCA2

Articles related to meningioma:

(show top 50)    (show all 631)

id	Title	Authors	Year	Affiliating Genes
1	Germline SMARCB1 mutation and somatic NF2 mutations i n familial multiple meningiomas. (20930055)	Christiaans I.... Hulsebos T.J.	2011	NF2, SMARCB1
2	Clinicopathological variables, immunophenotype, chrom osome 1p36 loss and tumour recurrence of 247 meningiomas grade I and II. (20054806)	Ruiz J.... Sanz-Ortega J.	2010	MDM2, CTSD, PGR
3	The cell growth inhibitory transcription factor C/EBP delta is expressed in human meningiomas in association with low histological gr ade and proliferation index. (19806320)	Barresi V.... Barresi G.	2010	CEBPD
4	Expression of ZIC family genes in meningiomas and oth er brain tumors. (20199689)	Aruga J.... Yokota N.	2010	ZIC3, ZIC2, ZIC1
5	Analysis of several PLA2 mRNA in human meningiomas. (20339511)	Denizot Y.... Labrousse F.	2009	PLA2G2A
6	Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas. (19034385)	Johnson M.D.... Bakos R.S.	2009	MAP2K1
7	Early malignant transformation of a petroclival menin gothelial meningioma. (19533187)	Ohba S.... Kawase T.	2009	TP53
8	Cystic papillary meningioma with subarachnoid dissemi nation: a case report and review of the literature. (19307065)	Zhi L.... Quan H.	2009	CHKA
9	Prognostic implications of biologic markers in intracranial meningiomas: 120 cases (18760426)	Metellus P.... Martin P.M.	2008	CTSD, CTSB, PLAU
10	XRCC1 and XRCC3 variants and risk of glioma and meningioma. (18330515)	Kiuru A.... Auvinen A.	2008	XRCC1, XRCC3
11	BCR expression is decreased in meningiomas showing loss of heterozygosity of 22q within a new minimal deletion region. (18474292)	Wozniak K.... Rieske P.	2008	BCR, NF2
12	Cytogenetic alterations in meningioma tumors and their impact on disease outcome (17335728)	Sayagues J.M.... Maillo A.	2007	NF2, MN1
13	CXCR4 and SDF1 expression in human meningiomas: a proliferative role in tumoral meningothelial cells in vitro. (17108064)	Bajetto A.... Florio T.	2007	CXCR4, MAPK1, CXCL12
14	Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas? (17961045)	Pfister C.... Roser F.	2007	PTGS2, ALOX5
15	De novo versus transformed atypical and anaplastic meningiomas: comparisons of clinical course, cytogenetics, cytokinetics, and outcome. (17881961)	KrayenbA1hl N.... Al-Mefty O.	2007	PGR
16	CXC receptor and chemokine expression in human meningioma: SDF1/CXCR4 signaling activates ERK1/2 and stimulates meningioma cell proliferation. (17384278)	Barbieri F.... Florio T.	2006	CXCR4, CSNK1A1, CXCL13
17	Microarray-based gene expression profiling of benign, atypical and anaplastic meningiomas identifies novel genes associated with meningioma progression. (15540215)	Wrobel G.... Lichter P.	2005	AKT3
18	Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas. (15832773)	Trinkaus M.... Lah T.T.	2005	CTSB, CTSL1, CST3
19	High throughput screening of meningioma biomarkers using a tissue microarray. (15980972)	Lusis E.A.... Perry A.	2005	CDH1, PDGFRB, CTSD
20	Epidermal growth factor receptor family (EGFR, ErbB2-4) in gliomas and meningiomas. (15148612)	Andersson U.... Henriksson R.	2004	EGFR, ERBB4, ERBB3
21	Chordoid meningioma: rare variant of meningioma. (15484703)	Ozen O.... Demirhan B.	2004	VIM, MUC1
22	Post-operative hematoma after surgery for intracranial meningiomas: causes, avoidable risk factors and clinical outcome. (14977059)	Gerlach R.... Seifert V.	2004	F2
23	111Indium-octreotide brain scintigraphy: a prognostic factor in skull base meningiomas treated with gamma knife radiosurgery. (15195001)	Nicolato A.	2004	SST
24	Expression of cytokeratin by malignant meningiomas: diagnostic pitfall of cytokeratin to separate malignant meningiomas from metastatic carcinoma. (15133478)	Liu Y.... Silverman J.F.	2004	VIM, MUC1
25	The eicosanoid cascade: possible role in gliomas and meningiomas. (14693827)	Nathoo N.... Golubic M.	2004	ALOX5
26	Hormone receptors in non-malignant meningiomas correlate with apoptosis, cell proliferation and recurrence-free survival. (12940781)	Konstantinidou A.E.... Patsouris E.	2003	BCL2, ESR1, MKI67
27	Meningioma with extensive noncalcifying collagenous whorls and glial fibrillary acidic protein expression: new variant of meningioma diagnosed by smear preparation. (12722124)	Pope L.Z.... Bleggi-Torres L.F.	2003	GFAP
28	A role for chromosome 9p21 deletions in the malignant progression of meningiomas and the prognosis of anaplastic meningiomas. (11958372)	Perry A.... Scheithauer B.W.	2002	CDKN2A
29	Loss of chromosome 22 and absence of NF2 gene mutation in a case of multiple meningiomas. (11979381)	Lomas J.... Rey J.A.	2002	NF2
30	Expression of PDGF and its receptor as well as their relationship to proliferating activity and apoptosis of meningiomas in human meningiomas. (11386826)	Yang S.Y.... Xu G.M.	2001	PCNA
31	Expression of the proliferating cell nuclear antigen and clinicopathological features in intracranial meningiomas. (11386825)	Kim C.H.... Oh S.J.	2001	PCNA
32	Intrinsic expression of drug resistance-associated factors in meningiomas. (11556752)	Tews D.S.... Gaumann A.K.	2001	ABCC1
33	Frequent loss of 1p32 region but no mutation of the p18 tumor suppressor gene in meningiomas. (11263500)	Leuraud P.... Sanson M.	2000	CDKN2C
34	Immunohistochemical expression of Ets-1 transcription factor and the urokinase-type plasminogen activator is correlated with the malignant and invasive potential in meningiomas. (11147600)	Kitange G.... Shibata S.	2000	PLAU, ETS1
35	Recurrence of meningiomas. (10964341)	Yamasaki F.... Kurisu K.	2000	VEGFA
36	Role of p53 gene mutation in tumor aggressiveness of intracranial meningiomas. (10331568)	Cho H.... Chae Y.S.	1999	TP53
37	Secretory meningioma, a rare meningioma subtype with characteristic glandular differentation: an histological and immunohistochemical study of 9 cases. (10655573)	Assi A.... Tonnarelli G.	1999	CEACAM7
38	Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M. (9488310)	Schrell U.M.... Fahlbusch R.	1998	IL6, LIFR, OSM
39	Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression. (9405679)	Weber R.G.... Lichter P.	1997	CDK4, TP53
40	Correlation of histopathologic classification with proliferative activity and DNA ploidy in 120 intracranial meningiomas, with special reference to atypical meningioma. (9250918)	Myong N.H.... Chi J.G.	1997	PCNA
41	Analysis of the neurofibromatosis 2 gene reveals molecular variants of meningioma. (7717450)	Wellenreuther R.... von Deimling A.	1995	NF2
42	Effect of suramin on 125I-insulin-like growth factor-I binding to human meningiomas and on proliferation of meningioma cells. (8113863)	Tsutsumi K.... Shibata S.	1994	IGF1
43	Correlation between sex hormone receptors and peritumoral edema in intracranial meningiomas. (7965139)	Maiuri F.... Signorelli F.	1994	PGR, ESR1
44	Somatostatin inhibits the activity of adenylate cyclase in cultured human meningioma cells and stimulates their growth. (1346787)	Koper J.W.... Reubi J.C.	1992	SST
45	Epithelial differentiation in gliomas, meningiomas and choroid plexus papillomas. (1352072)	Cruz-SA!nchez F.F.... Palacin A.	1992	VIM, MUC1
46	Expression of c-sis and c-fos genes in human meningiomas and neurinomas. (1353485)	Riva P.... Larizza L.	1992	FOS, PDGFB
47	Pseudopsammomatous meningioma with elevated serum carcinoembryonic antigen: a true secretory meningioma. Case report. (1984492)	Louis D.N.... Ojemann R.G.	1991	PSG2
48	Neurotensin high affinity binding sites and endopeptidase 24.11 are present respectively in the meningothelial and in the fibroblastic components of human meningiomas. (1965035)	Mailleux P.... Vanderhaeghen J.J.	1990	NTS
49	Gene expression of fibroblast growth factors in human gliomas and meningiomas: demonstration of cellular source of basic fibroblast growth factor mRNA and peptide in tumor tissues. (2377607)	Takahashi J.A.... Hatanaka M.	1990	FGF2
50	Hormonal dependency of cerebral meningiomas. Part 2: In vitro effect of steroids, bromocriptine, and epidermal growth factor on growth of meningiomas. (2213165)	Adams E.F.... Thierauf P.	1990	EGF, PGR

Genes related to meningioma according to GeneCards:

(show top 50)    (show all 617)

id	Symbol	Description	Score	GeneCards Section Context
1	MN1	meningioma (disrupted in balanced translocation) 1	11.1	Summaries, Transcripts, Publications, Aliases & Descriptions (show all 5 sections) Orthologs
2	PDGFB	platelet-derived growth factor beta polypeptide	11.1	Publications, Summaries
3	MGEA5	meningioma expressed antigen 5 (hyaluronidase)	11.1	Transcripts, Publications, Aliases & Descriptions, Functions (show all 5 sections) Orthologs
4	CTAGE5	CTAGE family, member 5	11.0	Publications, Aliases & Descriptions
5	AP1B1	adaptor-related protein complex 1, beta 1 subunit	11.0	Publications, Summaries
6	MNRI	meningioma, radiation-induced	11.0	Aliases & Descriptions
7	THOC5	THO complex 5	11.0	Publications, Aliases & Descriptions
8	NF2	neurofibromin 2 (merlin)	11.0	Publications
9	PGR	progesterone receptor	11.0	Publications
10	MUC1	mucin 1, cell surface associated	11.0	Publications
11	VIM	vimentin	11.0	Publications
12	EGFL6	EGF-like-domain, multiple 6	11.0	Summaries
13	CLTCL1	clathrin, heavy chain-like 1	11.0	Summaries
14	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
15	GFAP	glial fibrillary acidic protein	11.0	Publications
16	PCNA	proliferating cell nuclear antigen	11.0	Publications
17	ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	11.0	Publications
18	EPB41L3	erythrocyte membrane protein band 4.1-like 3	11.0	Publications, Functions
19	S100B	S100 calcium binding protein B	11.0	Publications
20	EGF	epidermal growth factor	11.0	Publications
21	NCAM1	neural cell adhesion molecule 1	11.0	Publications
22	HSD17B13	hydroxysteroid (17-beta) dehydrogenase 13	11.0	Publications
23	ALPL	alkaline phosphatase, liver/bone/kidney	11.0	Publications
24	CTSL1	cathepsin L1	11.0	Publications
25	CTSD	cathepsin D	11.0	Publications
26	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
27	CST3	cystatin C	11.0	Publications
28	DRD1	dopamine receptor D1	11.0	Publications
29	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
30	PTN	pleiotrophin	11.0	Publications
31	CTSB	cathepsin B	11.0	Publications
32	ESR1	estrogen receptor 1	11.0	Publications
33	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
34	PRLR	prolactin receptor	11.0	Publications
35	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	11.0	Publications
36	TERT	telomerase reverse transcriptase	11.0	Publications
37	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
38	VEGFA	vascular endothelial growth factor A	11.0	Publications
39	CD68	CD68 molecule	11.0	Publications
40	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	11.0	Publications
41	CAPN1	calpain 1, (mu/I) large subunit	11.0	Publications
42	S100A1	S100 calcium binding protein A1	11.0	Publications
43	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	11.0	Publications
44	KRT7	keratin 7	11.0	Publications
45	PTCH1	patched 1	11.0	Publications
46	SST	somatostatin	11.0	Publications
47	ALOX5	arachidonate 5-lipoxygenase	11.0	Publications
48	CCNA2	cyclin A2	11.0	Publications
49	PLAU	plasminogen activator, urokinase	11.0	Publications
50	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications

Pathways related to meningioma according to GeneDecks:

(show top 50)    (show all 221)

id	Pathway	Score	Top Affiliating Genes
1	ERK Signaling36	13.6	SEMA3A, VEGFB, MYC, BMP4, LIFR, LAMB1
2	Epithelial Adherens Junctions36	12.7	SEMA3A, VEGFB, BMP4, RAC1, RAC2, JUP
3	DNA Repair Mechanisms36	12.4	PCNA, BRCA2, LIG4, CHEK1, CHEK2, XRCC1
4	eIF2 Pathway36	12.1	SEMA3A, BMP4, INSR, FGF2, FGFR1, FGFR2
5	Complement and coagulation cascades20	12.0	SERPINC1, SERPINE1, SERPING1, CFB, CD55, CD46
6	all-trans-Retinoic Acid Signaling in Brain36	11.9	BMP4, RARA, LIF, BCL2, BAX, IL3
7	Immune response_Classical complement pathway41	11.9	SERPING1, CD93, CD55, CD46, ITGB2, C1QA
8	Ras Pathway36	11.9	SEMA3A, VEGFB, BMP4, RAC2, LIFR, KDR
9	Transcription_P53 signaling pathway41	11.9	RB1, VEGFA, KDR, BCL2, XPC, ATM
10	Chemokine signaling pathway20	11.9	PIK3CG, RAC1, RAC2, IL8, MAPK1, MAP2K1
11	Rap1 Pathway36	11.8	SEMA3A, VEGFB, BMP4, LIFR, ITGA3, ITGB2
12	Immune response Classic complement pathway10	11.7	SERPING1, CD93, CD55, CD46, ITGB2, CRP
13	Immune response Lectin Induced complement pathway10	11.7	SERPING1, CD93, CD55, CD46, ITGB2, MBL2
14	Cell adhesion ECM remodeling10	11.7	SERPINE1, VCAN, LAMB1, MSN, CD44, MMP12
15	Cell Cycle / Checkpoint Control3	11.7	RECQL4, PCNA, RB1, NBN, BRCA2, BRIP1
16	Transcription P53 signaling pathway10	11.7	VEGFA, CDKN2A, GTF2H1, GTF2H3, GTF2H5, TP53
17	Cell adhesion_ECM remodeling41	11.7	SERPINE1, VCAN, LAMB1, MSN, CD44, MMP12
18	Complement Pathway36	11.7	MBL2, MASP2, MASP1, C1QA, C1S, C1QB
19	Pathways in cancer20	11.7	PIK3CG, RET, RB1, BRCA2, VEGFA, VEGFB
20	Endothelin-1 Signaling Pathway36	11.6	MYC, BMP4, LIFR, FLT1, INSR, FGFR2
21	eNOS Signaling36	11.6	SEMA3A, LIFR, INSR, FGFR1, FGFR2, MET
22	Measles20	11.5	PIK3CG, MYD88, MSN, JAK1, CD209, CDKN1B
23	Immune response_Lectin induced complement pathway41	11.4	SERPING1, CD93, CD55, CD46, ITGB2, MBL2
24	IL-6 Pathway36	11.2	BMP4, BAX, IL3, IL8, MAPK1, MAP2K1
25	Pancreatic cancer20	11.1	BRCA2, RAC2, AKT3
26	EGFR Inhibitor Pathway, Pharmacodynamics34	11.1	KRAS, STAT2, STAT5A, STAT5B, STAT4
27	Immune response_Oncostatin M signaling via JAK-Stat in human cells41	11.1	SERPINA3, VEGFA, LIFR, JAK1, CCL2, CCL11
28	Immune response Oncostatin M signaling via JAK-Stat in human cells10	11.0	LIFR, JAK1, CCL2, CCL11, CCND1, TYK2
29	Colorectal cancer20	11.0	PIK3CG, RAC1, RAC2, MSH2, FOS, MAP2K1
30	MIF Mediated Glucocorticoid Regulation36	10.8	BMP4, LIF, BCL2, BAX, CD14, MIF
31	MIF Regulation of Innate Immune Cells36	10.8	BMP4, LIF, BCL2, BAX, CD14, FOS
32	Pertussis20	10.1	SERPING1, MYD88, CD14, ITGB2, FOS, IRAK4
33	Colorectal Cancer Metastasis36	10.1	MYC, BIRC5, BAX, MSH2, JAK1, CDKN1A
34	PTEN Pathway36	INF	SEMA3A, VEGFB, BMP4, RAC1, RAC2, KDR
35	Akt Signaling36	INF	PIK3CG, SEMA3A, VEGFB, BMP4, BMPR1A, LIF
36	Actin-Based Motility by Rho Family GTPases36	INF	SEMA3A, BMP4, RAC2, ITGB4, IGF1, GH1
37	NF-KappaB Family Pathway36	INF	SEMA3A, VEGFB, MYD88, BMP4, KDR, IRAK2
38	PPAR Pathway36	INF	SEMA3A, VEGFB, BMP4, ITGA3, ITGB2, ITGB4
39	JAK-STAT Pathway36	INF	SEMA3A, VEGFB, MYC, BMP4, LIFR, KDR
40	Mitochondrial Apoptosis36	INF	SEMA3A, VEGFB, BMP4, KDR, BCL2, CHEK2
41	Antioxidant Action of Vitamin-C36	INF	NCF2, NCF4, SEMA3A, VEGFB, BMP4, BMPR1A
42	NF-KappaB (p50-p65) Pathway36	INF	SEMA3A, VEGFB, MYD88, BMP4, KDR, IRAK2
43	DHA Signaling36	INF	SEMA3A, VEGFB, BMP4, KDR, BCL2, BAX
44	Rac1 Pathway36	INF	NCF2, SEMA3A, VEGFB, BMP4, RAC1, KDR
45	MAPK Family Pathway36	INF	SEMA3A, VEGFB, BMP4, RAC1, RAC2, KDR
46	CREB Pathway36	INF	SEMA3A, VEGFB, BMP4, KDR, FGFR1, FGFR2
47	Renin-Angiotensin Pathway36	INF	SEMA3A, VEGFB, VCAM1, BMP4, RAC1, KDR
48	Tec Kinases Signaling36	INF	SEMA3A, VEGFB, MYD88, BMP4, BMPR1A, RAC1
49	TGF-Beta Pathway36	INF	SEMA3A, VEGFB, BMP4, KDR, BCL2, BAX
50	ILK Signaling36	INF	SEMA3A, VIM, VEGFB, BMP4, RAC1, RAC2

Compounds related to meningioma according to GeneDecks:

(show top 50)    (show all 409)

id	Compound	Score	Top Affiliating Genes
1	cysteine32	INF	PCNA, SELP, SELPLG, SERPINA3, NAT2, LPO
2	calcium32 9 18 9	28.3	NCF2, NCL, RDX, RB1, SELPLG, SERPINB2
3	atp32	17.4	RFC1, NCAM1, NCF2, NCL, RET, RB1
4	glucose32	16.0	SETD2, VIPR1, VHL, LPO, VCAN, LMAN1
5	hydrogen32 18	15.9	SELPLG, SERPINB2, LPO, RARA, RAC1, BCR
6	formaldehyde32 18	14.5	PCNA, RB1, SELE, SELP, VIM, LPO
7	p00232	13.2	RB1, BRCA2, BIRC5, SCGB1A1, LEP, MVP
8	histidine32	13.1	VHL, RARA, SCG5, CHEK1, MTR, XRCC1
9	calcitriol32 42 9 18 9	16.9	NCOA2, NCOA3, RB1, MYC, RARA, LIF
10	vitamin d32	12.7	NCOA2, NCOA3, SERPINE1, VIM, RARA, SCG5
11	pd 98,05932	12.7	PIK3CG, NCL, RET, RB1, SETD2, SERPINE1
12	progestin32	12.5	SERPINC1, VIM, VEGFA, LIF, KDR, S100A6
13	progestins32	12.3	LIF, S100A6, MKI67, AR, FASN, CCND1
14	tamoxifen32 34 9 9	15.3	NCOA2, NCOA3, PCNA, SELE, SERPINC1, VIM
15	thymidylate32	12.2	PCNA, RB1, VIM, VEGFA, BIRC5, BCL2
16	trastuzumab32 34 9 9	15.2	PIK3CG, BIRC5, KDR, MUC1, CDKN1B, CDKN3
17	methotrexate32 34 42 9 9	16.2	PCNA, RB1, SELE, SERPINE1, SERPINA3, VIM
18	dihydrotestosterone32 9 18 9	15.1	NCOA2, NCOA3, SETD2, SERPINE1, VIM, LEP
19	octreotide32 42 9 9	15.0	VEGFA, MPO, MMP2, MKI67, INSR, ENO2
20	adp32 18	13.0	PIK3CG, RFC1, RET, SELP, SELPLG, SERPINC1
21	dmso32	12.0	SELP, VIM, S100A9, XDH, INSR, MAP2K1
22	endotoxin32	12.0	SERPINB2, BPI, MYD88, LIF, SCGB1A1, LBP
23	gp 13032	12.0	BMP4, LIF, LIFR, BCR, SCGB1A1, JAK1
24	reticulin32	11.8	PCNA, VIM, MUC1, S100B, CD79A, CD34
25	cocaine32 9 9	13.6	SELE, SELP, VIM, VCAM1, BCHE, LEP
26	egcg32	11.5	PIK3CG, FASN, MAP2K1, CCL5, ERBB3, ODC1
27	fmlp32	11.4	PIK3CG, NCF2, NCF4, SELP, SELPLG, SERPINA3
28	irinotecan32 34 9 9	14.4	VEGFA, CHEK1, BAX, MTHFR, XRCC1, CEACAM5
29	okadaic acid32 42	12.3	NCL, RB1, SERPINB2, VIM, MYC, BLZF1
30	cytarabine32 34 9 9	14.3	PCNA, RB1, VIM, MYC, LIF, BCL2
31	adpribose32	11.2	PIK3CG, PCNA, RB1, BRCA2, BIRC5, YY1
32	herbimycin a32 42	12.2	PIK3CG, RET, SELE, VCAM1, MYC, CD14
33	resveratrol32 9 18 9	14.1	PIK3CG, PCNA, RB1, BRCA2, VEGFA, BIRC5
34	n-formylmethionyl-leucylphenylalanine32	11.1	PIK3CG, NCF2, SELP, SELPLG, RAC2, MPO
35	ifn-alpha32	11.1	LIF, JAK1, CDKN2A, IL6, FAS, MAP2K1
36	imatinib32 34 9 9	14.0	PIK3CG, RET, VEGFA, MYC, RARA, BIRC5
37	arsenite32 18	12.0	PIK3CG, PCNA, SETD2, VEGFA, MYC, RARA
38	raloxifene32 9 9	13.0	NCOA3, SERPINC1, SERPINE1, CDKN1B, CDH1, CCL2
39	vitamin b1232	10.8	PCNA, SERPINA3, MTRR, MTHFR, MTR, B2M
40	prednisolone32 9 9	12.8	VCAM1, MYC, MVP, MPO, CD79A, CD14
41	indole-3-carbinol32	10.7	BRCA2, BIRC5, BCL2, BAX, CDKN1A, CDKN1B
42	oxaliplatin32 34 9 9	13.5	VEGFA, BIRC5, MTHFR, XRCC1, CEACAM5, CDKN1A
43	nitric oxide32 9 18 9	INF	NCAM1, NCF2, RB1, SELE, SELP, SERPINB2
44	indomethacin32 9 9	INF	PCNA, VIM, MYC, BIRC5, KDR, LEP
45	thymidine32 18	INF	PCNA, RB1, BRCA2, MYC, BMP4, RARA
46	cholesterol32 9 18 9	INF	NCOA2, RB1, SELE, SELP, SELPLG, SERPINE1
47	phosphotyrosine32	INF	PIK3CG, SH2D2A, RET, RDX, RAC1, BLZF1
48	arachidonic acid32 9 18 9	INF	NCAM1, NCF2, NCF4, SELP, VIM, RAC1
49	polysaccharide32	INF	NCAM1, NCOA3, GCNT2, SELE, SELP, SELPLG
50	ethanol32 34 9 18 9	INF	NCAM1, BPI, BCHE, CHKA, MUC1, MTR

Cellular components related to meningioma according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	INF	ZNF76, WDHD1, NCL, NCOA2, NCOA3, RECQL4
2	extracellular region	GO:005576	INF	NCAM1, NBL1, SERPINC1, SEMA3A, SERPINI1, SERPINB2
3	plasma membrane	GO:005886	INF	PIK3CG, NCAM1, PDCD10, RDX, SFRP1, SELE
4	cytosol	GO:005829	INF	PIK3CG, NCF2, NCF4, PDCD10, SFRP1, VIM
5	extracellular space	GO:005615	15.1	SFRP1, SELE, SELP, SERPINC1, SECTM1, SERPINB2
6	membrane	GO:016020	12.6	PIK3CG, NCF4, GCNT2, SELPLG, SEMA3A, VHL
7	basolateral plasma membrane	GO:016323	11.4	CEACAM5, CD44, CD46, ITGA3, AQP1, AQP4
8	external side of plasma membrane	GO:009897	11.2	NCAM1, SELP, VCAM1, KDR, SCNN1A, B2M
9	membrane attack complex	GO:005579	11.1	C6, C9, C7, C5, C8A, C8B
10	platelet alpha granule lumen	GO:031093	10.9	SERPINE1, SERPING1, VEGFA, VEGFB, FN1, IGF1
11	caveola	GO:005901	10.2	SELE, BMPR1A, ATP1A2, INSR, MAPK1, F2R
12	cell surface	GO:009986	INF	NCAM1, SFRP1, VEGFA, VCAM1, RARA, MSN
13	cytoplasm	GO:005737	INF	PIK3CG, WDHD1, SH2D2A, NCF2, NCOA3, RECQL4
14	nucleolus	GO:005730	INF	WDHD1, NCF2, NCL, NCOA3, RDX, PCNA
15	nucleoplasm	GO:005654	INF	WDHD1, RFC1, NCOA2, NCOA3, REV1, PCNA
16	integral to plasma membrane	GO:005887	INF	RET, CNTNAP1, SELP, SELPLG, VIPR1, BPI

Biological processes related to meningioma according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	14.5	SH2D2A, RET, CNTNAP1, SECTM1, MYD88, RARA
2	DNA repair	GO:006281	13.9	RFC1, RECQL4, REV1, PCNA, NBN, BRCA2
3	cell-cell signaling	GO:007267	13.7	S100A9, ITGB2, AR, INHA, INSL3, FGFR2
4	positive regulation of cell proliferation	GO:008284	13.4	PDCD10, SFRP1, NBN, VIPR1, VEGFA, MYC
5	immune response	GO:006955	13.3	NCF4, SECTM1, VIPR1, BPI, BMPR1A, LIF
6	inflammatory response	GO:006954	12.8	PIK3CG, SELE, SELP, SERPINA3, MYD88, RAC1
7	chemotaxis	GO:006935	12.7	S100A9, FGF2, MAPK1, MAP2K1, CCL8, CCL7
8	cell proliferation	GO:008283	12.7	SH2D2A, PCNA, NBN, NAB2, LIG4, BLZF1
9	nucleotide-excision repair	GO:006289	12.1	RFC1, PCNA, BRCA2, XPC, GTF2H1, GTF2H3
10	defense response to bacterium	GO:042742	12.1	BPI, FCER1G, CCL20, NOD1, NOD2, NOS2
11	positive regulation of cell migration	GO:030335	12.1	RET, VEGFA, KDR, LAMB1, FLT1, INSR
12	virus-host interaction	GO:019048	12.0	RB1, VIM, VCAM1, CLDN1, KDR, UNG
13	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	12.0	VEGFA, VEGFB, LIF, CD44, MIF, FCER1A
14	positive regulation of smooth muscle cell proliferation	GO:048661	11.9	MYD88, BMP4, IRAK4, FLT1, IL6, CCL5
15	positive regulation of endothelial cell proliferation	GO:001938	11.9	VEGFA, VEGFB, BMP4, KDR, FGF2, CCL26
16	cell surface receptor signaling pathway	GO:007166	11.9	MYD88, LIFR, CD14, MIF, INHA, MET
17	positive regulation of angiogenesis	GO:045766	11.8	SERPINE1, VEGFA, KDR, CD34, MMP9, FLT1
18	positive regulation of ERK1 and ERK2 cascade	GO:070374	11.8	VEGFB, BMP4, KDR, CD44, MIF, FGF2
19	elevation of cytosolic calcium ion concentration	GO:007204	11.8	CD55, CCR6, CCR4, CCKBR, CCR8, CCR1
20	response to glucocorticoid stimulus	GO:051384	11.7	SERPINE1, BCHE, INSR, IL6, APOA2, FAS
21	response to lipopolysaccharide	GO:032496	11.6	NCF2, SELE, SELP, LBP, S100A9, MMP9
22	angiogenesis	GO:001525	11.6	PIK3CG, SH2D2A, NCL, PDCD10, SETD2, SERPINE1
23	base-excision repair	GO:006284	11.5	PCNA, UNG, XRCC1, MPG, ERCC6, TP53
24	response to estradiol stimulus	GO:032355	11.4	BRCA2, BMP4, RARA, MMP9, INSR, ENO2
25	positive regulation of transcription from RNA polymerase II promoter	GO:045944	11.4	NCOA2, NCOA3, RB1, SERPINE1, VEGFA, MYC
26	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	11.4	SELP, KDR, FLT1, FGFR1, CCL5, IGF1
27	positive regulation of MAP kinase activity	GO:043406	11.4	PIK3CG, PDCD10, VEGFA, FLT1, FGFR1, GH1
28	positive regulation of MAPK cascade	GO:043410	11.3	LIF, KDR, LEP, FLT1, AR, INSR
29	heart development	GO:007507	11.2	PCNA, VCAM1, VCAN, ATM, CASP3, CASP8
30	blood coagulation	GO:007596	11.2	PIK3CG, SELP, SELPLG, SERPINC1, SERPINB2, SERPINE1
31	positive regulation of transcription, DNA-dependent	GO:045893	11.2	NCOA3, RET, SFRP1, RB1, BRCA2, VHL
32	cell cycle arrest	GO:007050	11.2	RB1, NBN, MYC, RASSF1, MSH2, ATM
33	negative regulation of apoptotic process	GO:043066	11.2	PIK3CG, PDCD10, SFRP1, SERPINE1, VEGFA, MYC
34	response to DNA damage stimulus	GO:006974	11.1	MYC, RASSF1, BLM, BCL2, CHEK1, CHEK2
35	response to gamma radiation	GO:010332	11.1	BRCA2, MYC, LIG4, BCL2, CHEK2, BAX
36	response to drug	GO:042493	10.8	NCF2, SFRP1, NBN, MYC, RAD54L, BCHE
37	cytokine-mediated signaling pathway	GO:019221	10.8	NCAM1, VCAM1, MYD88, LIFR, B2M, JAK1
38	aging	GO:007568	10.7	NCF2, VCAM1, FAS, CCL2, CCL5, F3
39	response to organic cyclic compound	GO:014070	10.6	NCF2, SFRP1, SELP, BMP4, MSH2, CDKN1A
40	response to hypoxia	GO:001666	10.6	VEGFA, VCAM1, BCL2, LEP, XRCC1, ATM
41	response to ethanol	GO:045471	10.2	BCL2, S100A9, MMP9, INSR, MGMT, CCL2
42	induction of apoptosis	GO:006917	9.7	BAX, CDKN2C, CDKN1B, CDKN2A, INHA, FAS
43	innate immune response	GO:045087	INF	PIK3CG, NCF2, SERPING1, MYD88, BCL2, LGALS3
44	complement activation, classical pathway	GO:006958	INF	SERPING1, CD55, CD46, MBL2, MASP2,
45	response to wounding	GO:009611	INF	RAC1, ITGB4, FN1, MET, CCR1, F2
46	positive regulation of fibroblast proliferation	GO:048146	INF	MYC, LIG4, XRCC4, S100A6, CDKN1A, CDK4
47	apoptotic process	GO:006915	INF	PDCD10, NBN, SEMA3A, VIM, RAC1, BIRC5
48	anti-apoptosis	GO:006916	INF	SERPINB2, VHL, VEGFB, MYD88, BIRC5, BCL2
49	complement activation	GO:006956	INF	CFB, MBL2, MASP2, MASP1, , IGLC2
50	negative regulation of cell proliferation	GO:008285	INF	SFRP1, VHL, BMP4, LIF, , CDKN1A

Molecular functions related to meningioma according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	TOLLIP, TFF1, TDG, TDP1, DES, STAT2
2	identical protein binding	GO:042802	12.8	SMAD4, TP73, TP63, TP53, ERBB2, ESR1
3	protein homodimerization activity	GO:042803	12.3	C1QB, HES1, TOP2A, TGFB1, DPP4, STAT1
4	receptor binding	GO:005102	12.1	SERPINE1, RARA, LIF, LBP, MSN, ITGB2
5	serine-type endopeptidase activity	GO:004252	11.9	KLK2, KLK4, KLK6, KLK7, KLKB1, C1S
6	growth factor activity	GO:008083	11.8	TGFB1, TGFA, TYMP, EGF, PDGFB, TFF1
7	heparin binding	GO:008201	11.6	CCL7, CCL2, CCL5, PTN, PTPRC, CTGF
8	damaged DNA binding	GO:003684	11.5	TDG, OGG1, POLQ, POLB, POLI, NEIL3
9	protein heterodimerization activity	GO:046982	11.5	EGFR, PDGFB, PDGFA, NR3C1, CYBA, TERF1
10	chemokine activity	GO:008009	11.2	CCL18, CCL13, CCL5, CXCL12, CXCL13, CXCL9
11	protein N-terminus binding	GO:047485	11.2	ERCC5, ERCC4, ERCC6, TP53, TSC1, TGFB1
12	enzyme binding	GO:019899	11.0	NOD2, PLAUR, CTNNB1, PTGS2, PTEN, TNKS2
13	protein tyrosine kinase activity	GO:004713	10.7	ERBB4, ERBB2, SRC, PDGFRB, EGFR, TYK2
14	protease binding	GO:002020	10.4	TP53, DPP4, CST3, CSTA, CSTB, POLG