MCID: MNN042
MIFTS: 38

Meningioma, Radiation-Induced

Categories: Rare diseases, Neuronal diseases, Endocrine diseases

Aliases & Classifications for Meningioma, Radiation-Induced

MalaCards integrated aliases for Meningioma, Radiation-Induced:

Name: Meningioma, Radiation-Induced 53 13
Radiation Induced Meningioma 49 69
Meningioma 55 69
Mnri 53 49
Meningioma, Benign, No Icd-O Subtype 69

Characteristics:

Orphanet epidemiological data:

55
meningioma
Prevalence: 1-9/100000 (United States),1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: All ages;

Classifications:



External Ids:

OMIM 53 606190
Orphanet 55 ORPHA2495
MESH via Orphanet 42 D008579
UMLS via Orphanet 70 C0025286
ICD10 via Orphanet 33 D32.9
MedGen 39 C1853554

Summaries for Meningioma, Radiation-Induced

MalaCards based summary : Meningioma, Radiation-Induced, also known as radiation induced meningioma, is related to meningioma, familial and cerebral meningioma, and has symptoms including ataxia, headache and seizures. An important gene associated with Meningioma, Radiation-Induced is PDGFB (Platelet Derived Growth Factor Subunit B), and among its related pathways/superpathways are Development EGFR signaling via small GTPases and Glioblastoma Multiforme. Affiliated tissues include pituitary, testes and brain, and related phenotypes are liver/biliary system and renal/urinary system

Description from OMIM: 606190

Related Diseases for Meningioma, Radiation-Induced

Diseases related to Meningioma, Radiation-Induced via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 meningioma, familial 29.3 NF2 PDGFB PTEN
2 cerebral meningioma 9.8
3 pten hamartoma tumor syndrome 9.7 NF2 PTEN
4 melanotic neurilemmoma 9.7 NF2 PTEN
5 glioblastoma multiforme 9.7 PDGFB PTEN
6 anaplastic ependymoma 9.6 NF2 PTEN
7 autosomal genetic disease 9.6 NF2 PTEN
8 glioblastoma 9.5 PDGFB PTEN
9 spinal meningioma 9.3 NF2 PDGFB PTEN

Graphical network of the top 20 diseases related to Meningioma, Radiation-Induced:



Diseases related to Meningioma, Radiation-Induced

Symptoms & Phenotypes for Meningioma, Radiation-Induced

Clinical features from OMIM:

606190

Human phenotypes related to Meningioma, Radiation-Induced:

55 (show top 50) (show all 74)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ataxia 55 Occasional (29-5%)
2 headache 55 Frequent (79-30%)
3 seizures 55 Frequent (79-30%)
4 syncope 55 Very rare (<4-1%)
5 back pain 55 Very rare (<4-1%)
6 nausea and vomiting 55 Frequent (79-30%)
7 excessive daytime somnolence 55 Very rare (<4-1%)
8 ophthalmoplegia 55 Occasional (29-5%)
9 lower limb muscle weakness 55 Occasional (29-5%)
10 hemiparesis 55 Occasional (29-5%)
11 obesity 55 Occasional (29-5%)
12 hydrocephalus 55 Occasional (29-5%)
13 emotional lability 55 Very rare (<4-1%)
14 neurological speech impairment 55 Very rare (<4-1%)
15 facial palsy 55 Occasional (29-5%)
16 increased intracranial pressure 55 Occasional (29-5%)
17 blindness 55 Very rare (<4-1%)
18 cognitive impairment 55 Occasional (29-5%)
19 cranial nerve paralysis 55 Occasional (29-5%)
20 hypogonadotrophic hypogonadism 55 Frequent (79-30%)
21 memory impairment 55 Occasional (29-5%)
22 neoplasm of the skin 55 Very rare (<4-1%)
23 papilledema 55 Occasional (29-5%)
24 difficulty walking 55 Occasional (29-5%)
25 proptosis 55 Very rare (<4-1%)
26 slow decrease in visual acuity 55 Occasional (29-5%)
27 focal seizures 55 Frequent (79-30%)
28 tinnitus 55 Very rare (<4-1%)
29 abnormality of the sense of smell 55 Occasional (29-5%)
30 cerebral hemorrhage 55 Very rare (<4-1%)
31 abnormality of the cerebellum 55 Occasional (29-5%)
32 secondary growth hormone deficiency 55 Frequent (79-30%)
33 impotence 55 Frequent (79-30%)
34 decreased circulating cortisol level 55 Frequent (79-30%)
35 decreased serum estradiol 55 Frequent (79-30%)
36 decreased testosterone in males 55 Frequent (79-30%)
37 pituitary hypothyroidism 55 Frequent (79-30%)
38 functional motor problems 55 Occasional (29-5%)
39 decreased circulating acth level 55 Frequent (79-30%)
40 bitemporal hemianopia 55 Frequent (79-30%)
41 abnormal kinetic perimetry test 55 Occasional (29-5%)
42 oculomotor nerve palsy 55 Occasional (29-5%)
43 prolactin excess 55 Frequent (79-30%)
44 abnormal brain fdg positron emission tomography 55 Frequent (79-30%)
45 neurofibromas 55 Occasional (29-5%)
46 chromosomal breakage induced by ionizing radiation 55 Very frequent (99-80%)
47 increased sensitivity to ionizing radiation 55 Very frequent (99-80%)
48 intracranial meningioma 55 Very frequent (99-80%)
49 amenorrhea 55 Frequent (79-30%)
50 focal t2 hypointense thalamic lesion 55 Frequent (79-30%)

MGI Mouse Phenotypes related to Meningioma, Radiation-Induced:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.13 NF2 PDGFB PTEN
2 renal/urinary system MP:0005367 8.8 NF2 PDGFB PTEN

Drugs & Therapeutics for Meningioma, Radiation-Induced

Search Clinical Trials , NIH Clinical Center for Meningioma, Radiation-Induced

Genetic Tests for Meningioma, Radiation-Induced

Anatomical Context for Meningioma, Radiation-Induced

MalaCards organs/tissues related to Meningioma, Radiation-Induced:

38
Pituitary, Testes, Brain, Skin, Tongue, Hypothalamus, Cerebellum

Publications for Meningioma, Radiation-Induced

Articles related to Meningioma, Radiation-Induced:

(show all 29)
# Title Authors Year
1
Radiation-induced meningiomas after BNCT in patients with malignant glioma. ( 26122975 )
2015
2
A radiation-induced meningioma "cures" a complex dural arteriovenous fistula. ( 23765916 )
2013
3
Tumor-to-tumor metastasis from pituitary carcinoma to radiation-induced meningioma. ( 22989053 )
2013
4
Metastatic olfactory neuroblastoma invading a radiation-induced meningioma. ( 21752653 )
2011
5
Radiation-induced meningiomas: a shadow in the success story of childhood leukemia. ( 19179425 )
2009
6
Radiation-induced meningioma concealed by shunt valve artifact: case report. ( 18424999 )
2008
7
Radiation-induced meningioma. ( 18447746 )
2008
8
Radiation-induced meningioma following prophylactic radiotherapy for acute lymphoblastic leukemia in childhood. ( 17190987 )
2007
9
Radiation induced meningioma with a short latent period following high dose cranial irradiation - case report and literature review. ( 16292489 )
2006
10
High-dose radiation-induced meningioma in children - case report and critical review of the literature. ( 15744628 )
2005
11
Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics. ( 15200115 )
2004
12
High dose radiation induced meningioma. ( 15799195 )
2004
13
Radiation-induced meningioma: a descriptive study of 253 cases. ( 12450029 )
2002
14
Radiation-induced meningioma with a long latency period: a case report. ( 11511997 )
2001
15
Radiation-induced meningioma: a distinct molecular genetic pattern? ( 10901233 )
2000
16
Radiation-induced meningioma evaluated with positron emission tomography with fludeoxyglucose F 18. ( 8733970 )
1996
17
Radiation-induced meningioma in children: report of two cases and review of the literature. ( 8753667 )
1996
18
Radiation-induced meningioma following radiation therapy for pituitary adenoma. Case report. ( 15096001 )
1996
19
Advanced nasopharyngeal carcinoma and radiation-induced meningioma in dizygotic twins--a rare case report. ( 8938229 )
1996
20
Radiation-induced meningioma. ( 8608584 )
1995
21
Radiation-induced meningioma with a 63-year latency period. Case report. ( 7861229 )
1995
22
Radiation-induced meningioma. ( 8166832 )
1994
23
[A juvenile case of radiation-induced meningioma two years after radiation for craniopharyngioma]. ( 8164804 )
1994
24
Chromosome 22 monosomy in a radiation-induced meningioma. ( 8354634 )
1993
25
A scalp lesion over an extracerebral mass: a sign of a radiation-induced meningioma. ( 1407528 )
1992
26
Radiation-induced meningioma. ( 2011241 )
1991
27
Radiation-induced meningioma after treatment for pituitary adenoma: case report and literature review. ( 2407971 )
1990
28
Radiation induced meningioma. A case report. ( 3716900 )
1986
29
Radiation-induced meningioma: with review of literature. ( 817405 )
1976

Variations for Meningioma, Radiation-Induced

ClinVar genetic disease variations for Meningioma, Radiation-Induced:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PTEN NM_000314.6(PTEN): c.701G> A (p.Arg234Gln) single nucleotide variant risk factor rs121909235 GRCh37 Chromosome 10, 89717676: 89717676
2 PDGFB PDGFB, 135-BP DEL, IVS5 deletion Pathogenic
3 NF2 NM_000268.3(NF2): c.995delA (p.Lys332Serfs) deletion Pathogenic rs587776563 GRCh37 Chromosome 22, 30064431: 30064431
4 NF2 NM_000268.3(NF2): c.169C> T (p.Arg57Ter) single nucleotide variant Pathogenic rs121434259 GRCh37 Chromosome 22, 30032794: 30032794

Expression for Meningioma, Radiation-Induced

Search GEO for disease gene expression data for Meningioma, Radiation-Induced.

Pathways for Meningioma, Radiation-Induced

Pathways related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.33 PDGFB PTEN
2 10.84 NF2 PDGFB PTEN
3 10.69 PDGFB PTEN

GO Terms for Meningioma, Radiation-Induced

Biological processes related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.37 PDGFB PTEN
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.32 PDGFB PTEN
3 regulation of cell cycle GO:0051726 9.26 NF2 PTEN
4 negative regulation of cell migration GO:0030336 9.16 NF2 PTEN
5 regulation of protein stability GO:0031647 8.96 NF2 PTEN
6 platelet-derived growth factor receptor signaling pathway GO:0048008 8.62 PDGFB PTEN

Molecular functions related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet-derived growth factor receptor binding GO:0005161 8.62 PDGFB PTEN

Sources for Meningioma, Radiation-Induced

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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