MNRI
MCID: MNN042
MIFTS: 27

Meningioma, Radiation-Induced (MNRI) malady

Categories: Rare diseases, Neuronal diseases, Endocrine diseases

Aliases & Classifications for Meningioma, Radiation-Induced

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Sources:
12diseasecard, 31ICD10 via Orphanet, 40MESH via Orphanet, 48NIH Rare Diseases, 52OMIM, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Meningioma, Radiation-Induced:

Name: Meningioma, Radiation-Induced 52 12
Radiation Induced Meningioma 48 68
Meningioma 54 68
 
Meningioma, Benign, No Icd-O Subtype 68
Mnri 48

Characteristics:

Orphanet epidemiological data:

54
meningioma:
Prevalence: 1-9/100000 (United States),1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: All ages

Classifications:



External Ids:

OMIM52 606190
Orphanet54 ORPHA2495
MESH via Orphanet40 D008579
UMLS via Orphanet69 C0025286
ICD10 via Orphanet31 D32.9

Summaries for Meningioma, Radiation-Induced

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MalaCards based summary: Meningioma, Radiation-Induced, also known as radiation induced meningioma, is related to meningioma, familial and spinal meningioma. An important gene associated with Meningioma, Radiation-Induced is PDGFB (Platelet Derived Growth Factor Subunit B), and among its related pathways are Development EGFR signaling via small GTPases and PDGFR-beta signaling pathway. Related mouse phenotypes are liver/biliary system and renal/urinary system.

Description from OMIM:52 606190

Related Diseases for Meningioma, Radiation-Induced

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Graphical network of the top 20 diseases related to Meningioma, Radiation-Induced:



Diseases related to meningioma, radiation-induced

Symptoms & Phenotypes for Meningioma, Radiation-Induced

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Clinical features from OMIM:

606190

MGI Mouse Phenotypes related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.5NF2, PDGFB, PTEN
2MP:00053678.8NF2, PDGFB, PTEN

Drugs & Therapeutics for Meningioma, Radiation-Induced

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Drugs for Meningioma, Radiation-Induced (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Armodafinilapproved, investigationalPhase 2197112111-43-0
Synonyms:
 
(–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide
R-modafinil
2
Modafinilapproved, investigationalPhase 219768693-11-84236
Synonyms:
2-((diphenylmethyl)sulfinyl)acetamide
Dea No. 1680
Modafinil
Modafinil [USAN:INN]
Modafinil [Usan:Inn]
Modafinilo
 
Modafinilo [Spanish]
Modafinilum
Modafinilum [Latin]
Moderateafinil
Modiodal
Provigil
Sparlon
modafinil
3Cytochrome P-450 CYP3A InducersPhase 21119
4Wakefulness-Promoting AgentsPhase 2193
5Central Nervous System StimulantsPhase 22211
6
Pioglitazoneapproved, investigationalPhase 1441111025-46-84829
Synonyms:
(+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+/-)-5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione
(+/-)-5-[p-[2-(ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione
105355-27-9
111025-46-8
198077-89-3
2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]- (9CI)
5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione
5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
5-[[4-[2-[(5-ethyl-2-pyridyl)]ethoxy]phenyl]methyl]thiazolidine- 2,4-dione
5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
AB1004597
AC-1021
AC1L1J1Q
AD 4833
AD-4833
Actos
Actos (TN)
Actost
BRD-A48430263-003-02-4
BSPBio_002723
C07675
C19H20N2O3S
CHEBI:8228
CHEMBL595
CID4829
D08378
DB01132
Duetact
Glustin
HMS2089H14
HS-0047
 
HSDB 7322
I06-0089
KBio2_002103
KBio2_004671
KBio2_007239
KBio3_001943
KBioGR_001619
KBioSS_002103
LS-151327
MolPort-002-508-211
NCGC00163128-01
NCGC00163128-02
Pioglitazona
Pioglitazona [INN-Spanish]
Pioglitazone
Pioglitazone HCl
Pioglitazone Hydrochloride
Pioglitazone [BAN:INN]
Pioglitazone [Ban:Inn]
Pioglitazone [INN:BAN]
Pioglitazonum
Pioglitazonum [INN-Latin]
SPBio_001897
Spectrum2_001679
Spectrum3_001002
Spectrum4_001130
Spectrum5_001480
Spectrum5_002067
Spectrum_001623
U 72107
U 72107A
U-72107
U72,107A
UNII-X4OV71U42S
Zactos
nchembio790-comp10
pioglitazone (INN)
pioglitazone HCl
7Hypoglycemic AgentsPhase 15896

Interventional clinical trials:

idNameStatusNCT IDPhase
1Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain TumorsCompletedNCT01032200Phase 2
2Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Treating Patients With Brain TumorsCompletedNCT01151670Phase 1
3Dose Response of Functionally Critical Brain Regions for Brain RadiotherapyUnknown statusNCT01212237Early Phase 1

Search NIH Clinical Center for Meningioma, Radiation-Induced

Genetic Tests for Meningioma, Radiation-Induced

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Anatomical Context for Meningioma, Radiation-Induced

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Publications for Meningioma, Radiation-Induced

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Variations for Meningioma, Radiation-Induced

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Clinvar genetic disease variations for Meningioma, Radiation-Induced:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PDGFBPDGFB, 135-BP DEL, IVS5deletionPathogenic
2NF2NM_ 000268.3(NF2): c.995delA (p.Lys332Serfs)deletionPathogenicrs587776563GRCh37Chr 22, 30064431: 30064431
3NF2NM_ 000268.3(NF2): c.169C> T (p.Arg57Ter)SNVPathogenicrs121434259GRCh37Chr 22, 30032794: 30032794
4PTENNM_ 000314.6(PTEN): c.701G> A (p.Arg234Gln)SNVPathogenic, risk factorrs121909235GRCh37Chr 10, 89717676: 89717676

Expression for genes affiliated with Meningioma, Radiation-Induced

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Search GEO for disease gene expression data for Meningioma, Radiation-Induced.

Pathways for genes affiliated with Meningioma, Radiation-Induced

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Pathways related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.4PDGFB, PTEN
29.4PDGFB, PTEN
38.8NF2, PDGFB, PTEN

GO Terms for genes affiliated with Meningioma, Radiation-Induced

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Biological processes related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heart developmentGO:000750710.1PDGFB, PTEN
2phosphatidylinositol-mediated signalingGO:004801510.0PDGFB, PTEN
3platelet-derived growth factor receptor signaling pathwayGO:004800810.0PDGFB, PTEN
4negative regulation of cell migrationGO:003033610.0NF2, PTEN
5positive regulation of ERK1 and ERK2 cascadeGO:00703749.9PDGFB, PTEN
6regulation of protein stabilityGO:00316479.3NF2, PTEN

Molecular functions related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor bindingGO:00051619.4PDGFB, PTEN

Sources for Meningioma, Radiation-Induced

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet