MCID: MNN042
MIFTS: 29

Meningioma, Radiation-Induced malady

Categories: Rare diseases, Neuronal diseases, Endocrine diseases

Aliases & Classifications for Meningioma, Radiation-Induced

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Sources:
12diseasecard, 30ICD10 via Orphanet, 39MESH via Orphanet, 47NIH Rare Diseases, 51OMIM, 53Orphanet, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Meningioma, Radiation-Induced:

Name: Meningioma, Radiation-Induced 51 12
Radiation Induced Meningioma 47 67
Meningioma 53 67
 
Meningioma, Benign, No Icd-O Subtype 67
Mnri 47

Characteristics:

Orphanet epidemiological data:

53
meningioma:
Prevalence: 1-9/100000 (United States),1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: All ages

Classifications:



External Ids:

OMIM51 606190
Orphanet53 ORPHA2495
MESH via Orphanet39 D008579
UMLS via Orphanet68 C0025286
ICD10 via Orphanet30 D32.9

Summaries for Meningioma, Radiation-Induced

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MalaCards based summary: Meningioma, Radiation-Induced, also known as radiation induced meningioma, is related to meningioma, familial and optic nerve sheath meningioma. An important gene associated with Meningioma, Radiation-Induced is PTEN (Phosphatase And Tensin Homolog), and among its related pathways are Development EGFR signaling via small GTPases and PDGFR-beta signaling pathway. Affiliated tissues include brain, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Description from OMIM:51 606190

Related Diseases for Meningioma, Radiation-Induced

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Graphical network of the top 20 diseases related to Meningioma, Radiation-Induced:



Diseases related to meningioma, radiation-induced

Symptoms for Meningioma, Radiation-Induced

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Clinical features from OMIM:

606190

Drugs & Therapeutics for Meningioma, Radiation-Induced

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Drugs for Meningioma, Radiation-Induced (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Armodafinilapproved, investigationalPhase 2195112111-43-0
Synonyms:
 
(–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide
R-modafinil
2
Modafinilapproved, investigationalPhase 219568693-11-84236
Synonyms:
Dea No. 1680
Modafinil
Modafinil [USAN:INN]
Modafinil [Usan:Inn]
Modafinilo
Modafinilo [Spanish]
 
Modafinilum
Modafinilum [Latin]
Moderateafinil
Modiodal
Provigil
Sparlon
modafinil
3Cytochrome P-450 CYP3A InducersPhase 21101
4Wakefulness-Promoting AgentsPhase 2192
5Central Nervous System StimulantsPhase 22132
6
Pioglitazoneapproved, investigationalPhase 1435111025-46-84829
Synonyms:
(+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+/-)-5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione
(+/-)-5-[p-[2-(ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione
105355-27-9
111025-46-8
198077-89-3
2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]- (9CI)
5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione
5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
5-[[4-[2-[(5-ethyl-2-pyridyl)]ethoxy]phenyl]methyl]thiazolidine- 2,4-dione
5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
AB1004597
AC-1021
AC1L1J1Q
AD 4833
AD-4833
Actos
Actos (TN)
Actost
BRD-A48430263-003-02-4
BSPBio_002723
C07675
C19H20N2O3S
CHEBI:8228
CHEMBL595
CID4829
D08378
DB01132
Duetact
Glustin
HMS2089H14
HS-0047
 
HSDB 7322
I06-0089
KBio2_002103
KBio2_004671
KBio2_007239
KBio3_001943
KBioGR_001619
KBioSS_002103
LS-151327
MolPort-002-508-211
NCGC00163128-01
NCGC00163128-02
Pioglitazona
Pioglitazona [INN-Spanish]
Pioglitazone
Pioglitazone HCl
Pioglitazone Hydrochloride
Pioglitazone [BAN:INN]
Pioglitazone [Ban:Inn]
Pioglitazone [INN:BAN]
Pioglitazonum
Pioglitazonum [INN-Latin]
SPBio_001897
Spectrum2_001679
Spectrum3_001002
Spectrum4_001130
Spectrum5_001480
Spectrum5_002067
Spectrum_001623
U 72107
U 72107A
U-72107
U72,107A
UNII-X4OV71U42S
Zactos
nchembio790-comp10
pioglitazone (INN)
pioglitazone HCl
7Hypoglycemic AgentsPhase 15733

Interventional clinical trials:

idNameStatusNCT IDPhase
1Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain TumorsCompletedNCT01032200Phase 2
2Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Treating Patients With Brain TumorsCompletedNCT01151670Phase 1
3Dose Response of Functionally Critical Brain Regions for Brain RadiotherapyUnknown statusNCT01212237Early Phase 1

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Genetic Tests for Meningioma, Radiation-Induced

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Anatomical Context for Meningioma, Radiation-Induced

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MalaCards organs/tissues related to Meningioma, Radiation-Induced:

35
Brain

Animal Models for Meningioma, Radiation-Induced or affiliated genes

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MGI Mouse Phenotypes related to Meningioma, Radiation-Induced:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.3NF2, PDGFB, PTEN
2MP:00053679.2NF2, PDGFB, PTEN
3MP:00053888.5NF2, PDGFB, PTEN

Publications for Meningioma, Radiation-Induced

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Variations for Meningioma, Radiation-Induced

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Clinvar genetic disease variations for Meningioma, Radiation-Induced:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PDGFBPDGFB, 135-BP DEL, IVS5deletionPathogenicChr na, -1: -1
2NF2NM_000268.3(NF2): c.169C> T (p.Arg57Ter)SNVPathogenicrs121434259GRCh37Chr 22, 30032794: 30032794
3PTENNM_000314.6(PTEN): c.701G> A (p.Arg234Gln)SNVPathogenic, risk factorrs121909235GRCh37Chr 10, 89717676: 89717676

Expression for genes affiliated with Meningioma, Radiation-Induced

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Search GEO for disease gene expression data for Meningioma, Radiation-Induced.

Pathways for genes affiliated with Meningioma, Radiation-Induced

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Pathways related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.3PDGFB, PTEN
29.3PDGFB, PTEN
38.5NF2, PDGFB, PTEN

GO Terms for genes affiliated with Meningioma, Radiation-Induced

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Biological processes related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:00480089.8PDGFB, PTEN
2phosphatidylinositol-mediated signalingGO:00480159.8PDGFB, PTEN
3heart developmentGO:00075079.4PDGFB, PTEN
4response to estradiolGO:00323559.3PDGFB, PTEN
5positive regulation of ERK1 and ERK2 cascadeGO:00703749.3PDGFB, PTEN
6regulation of protein stabilityGO:00316479.3NF2, PTEN
7negative regulation of cell migrationGO:00303368.8NF2, PTEN

Molecular functions related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor bindingGO:00051619.3PDGFB, PTEN

Sources for Meningioma, Radiation-Induced

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet