MNRI
MCID: MNN042
MIFTS: 27

Meningioma, Radiation-Induced (MNRI) malady

Categories: Rare diseases, Neuronal diseases, Endocrine diseases

Aliases & Classifications for Meningioma, Radiation-Induced

Aliases & Descriptions for Meningioma, Radiation-Induced:

Name: Meningioma, Radiation-Induced 54 13
Radiation Induced Meningioma 50 69
Meningioma 56 69
Meningioma, Benign, No Icd-O Subtype 69
Mnri 50

Characteristics:

Orphanet epidemiological data:

56
meningioma
Prevalence: 1-9/100000 (United States),1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: All ages;

Classifications:



External Ids:

OMIM 54 606190
Orphanet 56 ORPHA2495
MESH via Orphanet 43 D008579
UMLS via Orphanet 70 C0025286
ICD10 via Orphanet 34 D32.9

Summaries for Meningioma, Radiation-Induced

MalaCards based summary : Meningioma, Radiation-Induced, also known as radiation induced meningioma, is related to meningioma, familial and spinal meningioma. An important gene associated with Meningioma, Radiation-Induced is PDGFB (Platelet Derived Growth Factor Subunit B), and among its related pathways/superpathways are Development EGFR signaling via small GTPases and Glioblastoma Multiforme. The drugs Armodafinil and Modafinil have been mentioned in the context of this disorder. Related phenotypes are liver/biliary system and renal/urinary system

Description from OMIM: 606190

Related Diseases for Meningioma, Radiation-Induced

Graphical network of the top 20 diseases related to Meningioma, Radiation-Induced:



Diseases related to Meningioma, Radiation-Induced

Symptoms & Phenotypes for Meningioma, Radiation-Induced

Clinical features from OMIM:

606190

MGI Mouse Phenotypes related to Meningioma, Radiation-Induced:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.13 NF2 PDGFB PTEN
2 renal/urinary system MP:0005367 8.8 PTEN NF2 PDGFB

Drugs & Therapeutics for Meningioma, Radiation-Induced

Drugs for Meningioma, Radiation-Induced (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Armodafinil Approved, Investigational Phase 2 112111-43-0
2
Modafinil Approved, Investigational Phase 2 68693-11-8 4236
3 Central Nervous System Stimulants Phase 2
4 Cytochrome P-450 CYP3A Inducers Phase 2
5 Wakefulness-Promoting Agents Phase 2
6
Pioglitazone Approved, Investigational Phase 1 111025-46-8 4829
7 Hypoglycemic Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2
2 Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Treating Patients With Brain Tumors Completed NCT01151670 Phase 1
3 Dose Response of Functionally Critical Brain Regions for Brain Radiotherapy Unknown status NCT01212237 Early Phase 1

Search NIH Clinical Center for Meningioma, Radiation-Induced

Genetic Tests for Meningioma, Radiation-Induced

Anatomical Context for Meningioma, Radiation-Induced

Publications for Meningioma, Radiation-Induced

Variations for Meningioma, Radiation-Induced

ClinVar genetic disease variations for Meningioma, Radiation-Induced:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 NF2 NM_000268.3(NF2): c.995delA (p.Lys332Serfs) deletion Pathogenic rs587776563 GRCh37 Chromosome 22, 30064431: 30064431
2 NF2 NM_000268.3(NF2): c.169C> T (p.Arg57Ter) single nucleotide variant Pathogenic rs121434259 GRCh37 Chromosome 22, 30032794: 30032794
3 PTEN NM_000314.6(PTEN): c.701G> A (p.Arg234Gln) single nucleotide variant Pathogenic,risk factor rs121909235 GRCh37 Chromosome 10, 89717676: 89717676
4 PDGFB PDGFB, 135-BP DEL, IVS5 deletion Pathogenic

Expression for Meningioma, Radiation-Induced

Search GEO for disease gene expression data for Meningioma, Radiation-Induced.

Pathways for Meningioma, Radiation-Induced

Pathways related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.33 PDGFB PTEN
2 10.84 NF2 PDGFB PTEN
3 10.69 PDGFB PTEN

GO Terms for Meningioma, Radiation-Induced

Biological processes related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.37 PDGFB PTEN
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.32 PDGFB PTEN
3 phosphatidylinositol-mediated signaling GO:0048015 9.26 PDGFB PTEN
4 negative regulation of cell migration GO:0030336 9.16 NF2 PTEN
5 regulation of protein stability GO:0031647 8.96 NF2 PTEN
6 platelet-derived growth factor receptor signaling pathway GO:0048008 8.62 PDGFB PTEN

Molecular functions related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet-derived growth factor receptor binding GO:0005161 8.62 PDGFB PTEN

Sources for Meningioma, Radiation-Induced

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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